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Conserved domains on  [gi|2462551476|ref|XP_054170244|]
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voltage-dependent T-type calcium channel subunit alpha-1H isoform X8 [Homo sapiens]

Protein Classification

ion transporter( domain architecture ID 11997982)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium across cell membranes

CATH:  1.10.287.70
PubMed:  15816170
TCDB:  1.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
792-1019 1.39e-62

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 213.67  E-value: 1.39e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476  792 SKYFSRGIMMAILVNTLSMGVEYHEQPEE-LTNALEISNIVFTSMFALEMLLKLLACGP-LGYIRNPYNIFDGIIVVISV 869
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476  870 WEIV---GQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSlktD 946
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK---T 157
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462551476  947 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSS-WAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1293-1565 5.24e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 189.02  E-value: 5.24e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476 1293 HKMFDHVVLVFIFLNCVTIALERPDIDPGSTERvFLSVSNYIFTAIFVAEMMVKVVALGLLsgeHAYLQSSWNLLDGLLV 1372
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTT-VLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476 1373 LVSLVDIVVAMASAGGA-------------KIlgvlrvlrllrtlrplrvISRAPGLKLVVETLISSLRPIGNIVLICCA 1439
Cdd:pfam00520   77 LPSLISLVLSSVGSLSGlrvlrllrllrllRL------------------IRRLEGLRTLVNSLIRSLKSLGNLLLLLLL 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476 1440 FFIIFGILGVQLFKGKFYYCEGPDTRNistkaqcraahyrwvrrkYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGv 1519
Cdd:pfam00520  139 FLFIFAIIGYQLFGGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG- 199
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 2462551476 1520 dqqpvqnhNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQ 1565
Cdd:pfam00520  200 --------EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
99-430 3.77e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 155.12  E-value: 3.77e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476   99 NPWFEHVSMLVIMLNCVTLGMFRPCEDVECgseRCNILEAFDAFIFAFFAVEMVIKMVALGLFgqKCYLGDTWNRLDFFI 178
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP---LTTVLEILDYVFTGIFTLEMLLKIIAAGFK--KRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476  179 VVAGMMEYSLDGHN--VSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFfvffifgivgvqlwagll 256
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLL------------------ 137
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476  257 rnrCFLdsafvrnnnltflrpyyqteegeenpFICSSrrdNGMQkcshipgrreLRMPCTLGWEaytqpqaegvgaarna 336
Cdd:pfam00520  138 ---LFL--------------------------FIFAI---IGYQ----------LFGGKLKTWE---------------- 159
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476  337 cinwnqyynvcrsgdsNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCL 415
Cdd:pfam00520  160 ----------------NPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFI 223
                          330
                   ....*....|....*
gi 2462551476  416 VVIATQFSETKQRES 430
Cdd:pfam00520  224 AVIIDNFQELTERTE 238
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
792-1019 1.39e-62

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 213.67  E-value: 1.39e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476  792 SKYFSRGIMMAILVNTLSMGVEYHEQPEE-LTNALEISNIVFTSMFALEMLLKLLACGP-LGYIRNPYNIFDGIIVVISV 869
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476  870 WEIV---GQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSlktD 946
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK---T 157
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462551476  947 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSS-WAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1293-1565 5.24e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 189.02  E-value: 5.24e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476 1293 HKMFDHVVLVFIFLNCVTIALERPDIDPGSTERvFLSVSNYIFTAIFVAEMMVKVVALGLLsgeHAYLQSSWNLLDGLLV 1372
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTT-VLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476 1373 LVSLVDIVVAMASAGGA-------------KIlgvlrvlrllrtlrplrvISRAPGLKLVVETLISSLRPIGNIVLICCA 1439
Cdd:pfam00520   77 LPSLISLVLSSVGSLSGlrvlrllrllrllRL------------------IRRLEGLRTLVNSLIRSLKSLGNLLLLLLL 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476 1440 FFIIFGILGVQLFKGKFYYCEGPDTRNistkaqcraahyrwvrrkYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGv 1519
Cdd:pfam00520  139 FLFIFAIIGYQLFGGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG- 199
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 2462551476 1520 dqqpvqnhNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQ 1565
Cdd:pfam00520  200 --------EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
99-430 3.77e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 155.12  E-value: 3.77e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476   99 NPWFEHVSMLVIMLNCVTLGMFRPCEDVECgseRCNILEAFDAFIFAFFAVEMVIKMVALGLFgqKCYLGDTWNRLDFFI 178
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP---LTTVLEILDYVFTGIFTLEMLLKIIAAGFK--KRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476  179 VVAGMMEYSLDGHN--VSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFfvffifgivgvqlwagll 256
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLL------------------ 137
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476  257 rnrCFLdsafvrnnnltflrpyyqteegeenpFICSSrrdNGMQkcshipgrreLRMPCTLGWEaytqpqaegvgaarna 336
Cdd:pfam00520  138 ---LFL--------------------------FIFAI---IGYQ----------LFGGKLKTWE---------------- 159
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476  337 cinwnqyynvcrsgdsNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCL 415
Cdd:pfam00520  160 ----------------NPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFI 223
                          330
                   ....*....|....*
gi 2462551476  416 VVIATQFSETKQRES 430
Cdd:pfam00520  224 AVIIDNFQELTERTE 238
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
792-1019 1.39e-62

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 213.67  E-value: 1.39e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476  792 SKYFSRGIMMAILVNTLSMGVEYHEQPEE-LTNALEISNIVFTSMFALEMLLKLLACGP-LGYIRNPYNIFDGIIVVISV 869
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476  870 WEIV---GQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSlktD 946
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLK---T 157
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462551476  947 TGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSS-WAALYFVALMTFGNYVLFNLLVAILVEGFQ 1019
Cdd:pfam00520  158 WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1293-1565 5.24e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 189.02  E-value: 5.24e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476 1293 HKMFDHVVLVFIFLNCVTIALERPDIDPGSTERvFLSVSNYIFTAIFVAEMMVKVVALGLLsgeHAYLQSSWNLLDGLLV 1372
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTT-VLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476 1373 LVSLVDIVVAMASAGGA-------------KIlgvlrvlrllrtlrplrvISRAPGLKLVVETLISSLRPIGNIVLICCA 1439
Cdd:pfam00520   77 LPSLISLVLSSVGSLSGlrvlrllrllrllRL------------------IRRLEGLRTLVNSLIRSLKSLGNLLLLLLL 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476 1440 FFIIFGILGVQLFKGKFYYCEGPDTRNistkaqcraahyrwvrrkYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGv 1519
Cdd:pfam00520  139 FLFIFAIIGYQLFGGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG- 199
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*.
gi 2462551476 1520 dqqpvqnhNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQ 1565
Cdd:pfam00520  200 --------EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
99-430 3.77e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 155.12  E-value: 3.77e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476   99 NPWFEHVSMLVIMLNCVTLGMFRPCEDVECgseRCNILEAFDAFIFAFFAVEMVIKMVALGLFgqKCYLGDTWNRLDFFI 178
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP---LTTVLEILDYVFTGIFTLEMLLKIIAAGFK--KRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476  179 VVAGMMEYSLDGHN--VSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFfvffifgivgvqlwagll 256
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLL------------------ 137
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476  257 rnrCFLdsafvrnnnltflrpyyqteegeenpFICSSrrdNGMQkcshipgrreLRMPCTLGWEaytqpqaegvgaarna 336
Cdd:pfam00520  138 ---LFL--------------------------FIFAI---IGYQ----------LFGGKLKTWE---------------- 159
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476  337 cinwnqyynvcrsgdsNPHNGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCL 415
Cdd:pfam00520  160 ----------------NPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFI 223
                          330
                   ....*....|....*
gi 2462551476  416 VVIATQFSETKQRES 430
Cdd:pfam00520  224 AVIIDNFQELTERTE 238
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
875-1018 4.04e-03

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 40.72  E-value: 4.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462551476  875 QADGGLSVLRTFRLLRVLKLVRFlpalRRQLVVLVKTM----DNVATFCTLLMLFIFIFSILGMHLFGCKFSlktdtgdt 950
Cdd:pfam08016   95 LYRIILAFLVFLTWLKLFKVLRF----NKTMSLFTKTLsrawKDLAGFALMFVIFFFAYAQFGYLLFGTQAP-------- 162
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462551476  951 vpdrkNFDSLLWAIVTVFQILtqedWNVVLYNGMASTSSW-AALYFVALMTFGNYVLFNLLVAILVEGF 1018
Cdd:pfam08016  163 -----NFSNFVKSILTLFRTI----LGDFGYNEIFSGNRVlGPLLFLTFVFLVIFILLNLFLAIINDSY 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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