NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462553727|ref|XP_054171338|]
View 

LYR motif-containing protein 9 isoform X2 [Homo sapiens]

Protein Classification

LYR motif-containing protein 9( domain architecture ID 14448886)

LYR motif-containing protein 9 (LYRM9)

PubMed:  24059529

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Complex1_LYR_LYRM9 cd20269
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 9 (LYRM9) and ...
 39-99 7.69e-31

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 9 (LYRM9) and similar proteins; LYRM9 is an uncharacterized LYR motif-containing protein that belongs to the Complex1_LYR-like superfamily which consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


:

Pssm-ID: 380764  Cd Length: 60  Bit Score: 103.48  E-value: 7.69e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462553727  39 PLQLYRYLLRCCQQLPtKGIQQHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADWIMNK 99
Cdd:cd20269     1 PLQLYRYLLRCCRRLP-KDTRDYYRHYARQNFVSHRDEDDPERIQQIIERAYEDAKWVLKK 60
 
Name Accession Description Interval E-value
Complex1_LYR_LYRM9 cd20269
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 9 (LYRM9) and ...
 39-99 7.69e-31

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 9 (LYRM9) and similar proteins; LYRM9 is an uncharacterized LYR motif-containing protein that belongs to the Complex1_LYR-like superfamily which consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380764  Cd Length: 60  Bit Score: 103.48  E-value: 7.69e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462553727  39 PLQLYRYLLRCCQQLPtKGIQQHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADWIMNK 99
Cdd:cd20269     1 PLQLYRYLLRCCRRLP-KDTRDYYRHYARQNFVSHRDEDDPERIQQIIERAYEDAKWVLKK 60
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 37-95 4.83e-13

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 58.36  E-value: 4.83e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462553727  37 RRPLQLYRYLLRCCQQLPTKGIQQHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADW 95
Cdd:pfam05347   1 RQVLSLYRALLRAARKFPDYNFREYFRRRIRDEFRKNKDLTDPEKIEKLLKEGKEELEE 59
 
Name Accession Description Interval E-value
Complex1_LYR_LYRM9 cd20269
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 9 (LYRM9) and ...
 39-99 7.69e-31

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 9 (LYRM9) and similar proteins; LYRM9 is an uncharacterized LYR motif-containing protein that belongs to the Complex1_LYR-like superfamily which consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380764  Cd Length: 60  Bit Score: 103.48  E-value: 7.69e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462553727  39 PLQLYRYLLRCCQQLPtKGIQQHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADWIMNK 99
Cdd:cd20269     1 PLQLYRYLLRCCRRLP-KDTRDYYRHYARQNFVSHRDEDDPERIQQIIERAYEDAKWVLKK 60
Complex1_LYR_SF cd20251
LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The ...
 39-95 3.29e-13

LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily; The Complex1_LYR-like superfamily consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. The human genome has at least ten LYR proteins that were predominantly identified as mitochondrial proteins. Some family members were also found in the cytosol or nucleus. LYR motif-containing protein 4 (LYRM4) represents the only LYR protein that is directly involved in the first steps of Fe-S cluster generation. Other LYR proteins have been identified as accessory subunits or assembly factors of mitochondrial OXPHOS (oxidative phosphorylation) complexes I, II, III and V, and they play specific roles in acetate metabolism.


Pssm-ID: 380755  Cd Length: 57  Bit Score: 58.71  E-value: 3.29e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462553727  39 PLQLYRYLLRCCQQLPTKGIQQHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADW 95
Cdd:cd20251     1 VLKLYRDLLRLARKGLPSRKRDALRQRIREEFRKNKNETDPEKIEELLAEARRGLKN 57
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 37-95 4.83e-13

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 58.36  E-value: 4.83e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462553727  37 RRPLQLYRYLLRCCQQLPTKGIQQHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDADW 95
Cdd:pfam05347   1 RQVLSLYRALLRAARKFPDYNFREYFRRRIRDEFRKNKDLTDPEKIEKLLKEGKEELEE 59
Complex1_LYR_unchar cd20273
LYR (leucine-tyrosine-arginine) motif found in uncharacterized LYR motif-containing protein; ...
 39-89 8.17e-08

LYR (leucine-tyrosine-arginine) motif found in uncharacterized LYR motif-containing protein; This group contains uncharacterized LYR motif-containing proteins belonging to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380768  Cd Length: 61  Bit Score: 45.26  E-value: 8.17e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462553727  39 PLQLYRYLLRCCQQLPTKGIQQHYKHAVRQSFRVHSDEDNPERIQQIIKRA 89
Cdd:cd20273     1 ALALYRALLREASYLPDPVARNYLRNHIRSRFRKNRNETSPKRLRKRLKKA 51
Complex1_LYR_LYRM2 cd20262
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 2 (LYRM2) and ...
 40-83 1.38e-03

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 2 (LYRM2) and similar proteins; LYRM2 is an uncharacterized LYR motif-containing protein that belongs to the Complex1_LYR-like superfamily which consists of proteins of diverse functions that are exclusively found in eukaryotes; these proteins contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380757  Cd Length: 63  Bit Score: 34.05  E-value: 1.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 2462553727  40 LQLYRYLLRCCQQLPTKGIQQHYKHAVRQSFRVHSDEDNPERIQ 83
Cdd:cd20262     7 LSLYRDILRAIRKIPDPSTRRELRDWVREEFERNRNETDEDAIK 50
Complex1_LYR_LYRM4 cd20264
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and ...
 40-94 2.16e-03

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and similar proteins; LYRM4, also called ISD11, is a eukaryote-specific component of the mitochondrial biogenesis of Fe-S clusters which are essential cofactors in multiple processes, including oxidative phosphorylation. It is required for nuclear and mitochondrial iron-sulfur protein biosynthesis by forming a complex with, and stabilizing, the sulfur donor NFS1. LYRM4 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380759  Cd Length: 69  Bit Score: 34.03  E-value: 2.16e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462553727  40 LQLYRYLLRCCQQLPTKGIQQHYKHAVRQSFRVHSDEDNPERIQQIIKRAIEDAD 94
Cdd:cd20264     3 LSLYRALLREARKFPDYNFREYFLRRIRDAFRENKNLKDPEEIKKLYEEGEEQLE 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH