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Conserved domains on  [gi|2462555497|ref|XP_054172209|]
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myosin-3 isoform X1 [Homo sapiens]

Protein Classification

myosin heavy chain( domain architecture ID 13678267)

myosin heavy chain of class II myosin (or conventional myosin), which contains two heavy chains made up of the motor/head (N-terminal) and coiled-coil tail (C-terminal) domains; the head ATPase activity and functions as a molecular motor, utilizing ATP hydrolysis to generate directed movement toward the plus end along actin filaments

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MYSc_Myh3 cd14913
class II myosin heavy chain 3, motor domain; Myosin motor domain of fetal skeletal muscle ...
100-767 0e+00

class II myosin heavy chain 3, motor domain; Myosin motor domain of fetal skeletal muscle myosin heavy chain 3 (MYHC-EMB, MYHSE1, HEMHC, SMHCE) in tetrapods including mammals, lizards, and frogs. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


:

Pssm-ID: 276878 [Multi-domain]  Cd Length: 668  Bit Score: 1447.94  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14913      1 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 259
Cdd:cd14913     81 ESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  260 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDI 339
Cdd:cd14913    161 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  340 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVD 419
Cdd:cd14913    241 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVD 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  420 QVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQ 499
Cdd:cd14913    321 QVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQ 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  500 EEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFS 579
Cdd:cd14913    401 EEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFS 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  580 LIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKL 659
Cdd:cd14913    481 LIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKL 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  660 MSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDS 739
Cdd:cd14913    561 MSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDS 640
                          650       660
                   ....*....|....*....|....*...
gi 2462555497  740 KKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14913    641 KKACEKLLASIDIDHTQYKFGHTKVFFK 668
Myosin_tail_1 super family cl37647
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
847-1924 1.11e-155

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


The actual alignment was detected with superfamily member pfam01576:

Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 508.95  E-value: 1.11e-155
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTER 926
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESR 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  927 AEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQ 1006
Cdd:pfam01576   84 LEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERISE 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1007 ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDF 1086
Cdd:pfam01576  164 FTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEE 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1087 EYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK 1166
Cdd:pfam01576  244 ELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRS 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1167 KREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANL 1246
Cdd:pfam01576  324 KREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDS 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1247 EKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKA 1326
Cdd:pfam01576  404 EHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQ 483
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1327 KNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAiQRTEELEEAKKKLAQRLQDSEEQVE 1406
Cdd:pfam01576  484 KLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDA-GTLEALEEGKKRLQRELEALTQQLE 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1407 AVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKC-----EESQAELEASLKESRSLSte 1481
Cdd:pfam01576  563 EKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISaryaeERDRAEAEAREKETRALS-- 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1482 lfkLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILR 1561
Cdd:pfam01576  641 ---LARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLR 717
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1562 IQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETL 1641
Cdd:pfam01576  718 LEVNMQALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAV 797
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1642 KHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQN 1721
Cdd:pfam01576  798 KQLKKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGASGK 877
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1722 TSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA 1801
Cdd:pfam01576  878 SALQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEM 957
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1802 EQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKR 1881
Cdd:pfam01576  958 EGTVKSKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKR 1037
                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|...
gi 2462555497 1882 QAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAK 1924
Cdd:pfam01576 1038 QLEEAEEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
Myosin_N pfam02736
Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the ...
33-77 6.62e-12

Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.


:

Pssm-ID: 460670  Cd Length: 45  Bit Score: 61.68  E-value: 6.62e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462555497   33 DAKTYCFVVDSKEEYAKGKIKSSQDGKVTVETEDNRTLVVKPEDV 77
Cdd:pfam02736    1 DAKKLVWVPDPKEGFVKGEIKEEEGDKVTVETEDGKTVTVKKDDV 45
 
Name Accession Description Interval E-value
MYSc_Myh3 cd14913
class II myosin heavy chain 3, motor domain; Myosin motor domain of fetal skeletal muscle ...
100-767 0e+00

class II myosin heavy chain 3, motor domain; Myosin motor domain of fetal skeletal muscle myosin heavy chain 3 (MYHC-EMB, MYHSE1, HEMHC, SMHCE) in tetrapods including mammals, lizards, and frogs. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276878 [Multi-domain]  Cd Length: 668  Bit Score: 1447.94  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14913      1 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 259
Cdd:cd14913     81 ESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  260 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDI 339
Cdd:cd14913    161 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  340 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVD 419
Cdd:cd14913    241 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVD 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  420 QVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQ 499
Cdd:cd14913    321 QVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQ 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  500 EEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFS 579
Cdd:cd14913    401 EEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFS 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  580 LIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKL 659
Cdd:cd14913    481 LIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKL 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  660 MSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDS 739
Cdd:cd14913    561 MSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDS 640
                          650       660
                   ....*....|....*....|....*...
gi 2462555497  740 KKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14913    641 KKACEKLLASIDIDHTQYKFGHTKVFFK 668
Myosin_head pfam00063
Myosin head (motor domain);
88-767 0e+00

Myosin head (motor domain);


Pssm-ID: 395017 [Multi-domain]  Cd Length: 674  Bit Score: 1030.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   88 IEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFML 167
Cdd:pfam00063    1 VEDMVELSYLNEPSVLHNLKKRYKSDLIYTYSGLVLVAVNPYKQLPIYSEDMIKAYRGKRRGELPPHIFAIADEAYRSML 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  168 TDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKkkdskmKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGK 247
Cdd:pfam00063   81 QDKENQSILISGESGAGKTENTKKIMQYLASVSGSGSAGN------VGRLEEQILQSNPILEAFGNAKTVRNNNSSRFGK 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  248 FIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLItTNPYDYPFISQ-GEILVASIDD 326
Cdd:pfam00063  155 YIEIQFDAKGDIVGGKIETYLLEKSRVVYQAEGERNYHIFYQLLAGASAQLKKELRL-TNPKDYHYLSQsGCYTIDGIDD 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  327 AEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVK 406
Cdd:pfam00063  234 SEEFKITDKAMDILGFSDEEQMGIFRIVAAILHLGNIEFKKERNDEQAVPDDTENLQKAASLLGIDSTELEKALCKRRIK 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  407 VGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLD-TKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEK 485
Cdd:pfam00063  314 TGRETVSKPQNVEQANYARDALAKAIYSRLFDWLVDRINKSLDvKTIEKASFIGVLDIYGFEIFEKNSFEQLCINYVNEK 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  486 LQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKLYDQHlGKSNNF 564
Cdd:pfam00063  394 LQQFFNHHMFKLEQEEYVREGIEWTFIDFG-DNQPCIDLIEkKPLGILSLLDEECLFPKATDQTFLDKLYSTF-SKHPHF 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  565 QKPKVvkgRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATAD----ADSGKKKVAKK 640
Cdd:pfam00063  472 QKPRL---QGETHFIIKHYAGDVEYNVEGFLEKNKDPLNDDLVSLLKSSSDPLLAELFPDYETAEsaaaNESGKSTPKRT 548
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  641 KGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFK 720
Cdd:pfam00063  549 KKKRFITVGSQFKESLGELMKTLNSTNPHYIRCIKPNEKKRAGVFDNSLVLHQLRCNGVLEGIRIRRAGFPNRITFQEFV 628
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 2462555497  721 QRYRVLNASAIPEGqFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:pfam00063  629 QRYRILAPKTWPKW-KGDAKKGCEAILQSLNLDKEEYQFGKTKIFFR 674
MYSc smart00242
Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical ...
81-779 0e+00

Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.


Pssm-ID: 214580 [Multi-domain]  Cd Length: 677  Bit Score: 989.74  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497    81 NPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISD 160
Cdd:smart00242    1 NPPKFEGVEDLVLLTYLNEPAVLHNLKKRYLKDLIYTYIGLVLVAVNPYKQLPIYTDEVIKKYRGKSRGELPPHVFAIAD 80
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   161 NAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATgdlakkkdSKMKGTLEDQIISANPLLEAFGNAKTVRND 240
Cdd:smart00242   81 NAYRNMLNDKENQSIIISGESGAGKTENTKKIMQYLASVSGS--------NTEVGSVEDQILESNPILEAFGNAKTLRNN 152
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   241 NSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTnPYDYPFISQG-EI 319
Cdd:smart00242  153 NSSRFGKFIEIHFDAKGKIIGAKIETYLLEKSRVVSQAKGERNYHIFYQLLAGASEELKKELGLKS-PEDYRYLNQGgCL 231
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   320 LVASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQA-EPDGTEVADKTAYLMGLNSSDLLK 398
Cdd:smart00242  232 TVDGIDDAEEFKETLNAMRVLGFSEEEQESIFKILAAILHLGNIEFEEGRNDNAAsTVKDKEELSNAAELLGVDPEELEK 311
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   399 ALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLC 478
Cdd:smart00242  312 ALTKRKIKTGGEVITKPLNVEQALDARDALAKALYSRLFDWLVKRINQSLSFKDGSTYFIGVLDIYGFEIFEVNSFEQLC 391
                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   479 INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKLYdQH 557
Cdd:smart00242  392 INYANEKLQQFFNQHVFKLEQEEYEREGIDWTFIDFF-DNQDCIDLIEkKPPGILSLLDEECRFPKGTDQTFLEKLN-QH 469
                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   558 LGKSNNFQKPKVvkgRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYatfatadadsGKKKV 637
Cdd:smart00242  470 HKKHPHFSKPKK---KGRTEFIIKHYAGDVTYDVTGFLEKNKDTLSDDLIELLQSSKNPLIASLF----------PSGVS 536
                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   638 AKKKGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYG 717
Cdd:smart00242  537 NAGSKKRFQTVGSQFKEQLNELMDTLNSTNPHFIRCIKPNEEKKPGDFDSSLVLHQLRYLGVLENIRIRRAGFPYRLPFD 616
                           650       660       670       680       690       700
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462555497   718 DFKQRYRVLNASAIPEGQFiDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRD 779
Cdd:smart00242  617 EFLQRYRVLLPDTWPPWGG-DAKKACEALLQSLGLDEDEYQLGKTKVFLRPGQLAELEELRE 677
COG5022 COG5022
Myosin heavy chain [General function prediction only];
31-1112 0e+00

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 832.03  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   31 PFDAKTYCFVVDSKEEYAKGKIKSsqdgkvTVETEDNRTLVVKPEDV--YAMNPPKFDRIEDMAMLTHLNEPAVLYNLKD 108
Cdd:COG5022     15 PDEEKGWIWAEIIKEAFNKGKVTE------EGKKEDGESVSVKKKVLgnDRIKLPKFDGVDDLTELSYLNEPAVLHNLEK 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  109 RYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVN 188
Cdd:COG5022     89 RYNNGQIYTYSGLVLIAVNPYRDLGIYTDDIIQSYSGKNRLELEPHVFAIAEEAYRNLLSEKENQTIIISGESGAGKTEN 168
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  189 TKRVIQYFATIAATgdlakkkDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYL 268
Cdd:COG5022    169 AKRIMQYLASVTSS-------STVEISSIEKQILATNPILEAFGNAKTVRNDNSSRFGKYIKIEFDENGEICGAKIETYL 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  269 LEKSRVTFQLKAERSYHIFYQILSNKkPELIELLLITTNPYDYPFISQGE-ILVASIDDAEELLATDSAIDILGFTPEEK 347
Cdd:COG5022    242 LEKSRVVHQNKNERNYHIFYQLLAGD-PEELKKLLLLQNPKDYIYLSQGGcDKIDGIDDAKEFKITLDALKTIGIDEEEQ 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  348 SGLYKLTGAVMHYGNMKFKqKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNA 427
Cdd:COG5022    321 DQIFKILAAILHIGNIEFK-EDRNGAAIFSDNSVLDKACYLLGIDPSLFVKWLVKRQIKTGGEWIVVPLNLEQALAIRDS 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  428 LSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGI 507
Cdd:COG5022    400 LAKALYSNLFDWIVDRINKSLDHSAAASNFIGVLDIYGFEIFEKNSFEQLCINYTNEKLQQFFNQHMFKLEQEEYVKEGI 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  508 EWTFIDFgMDLAACIELIEK--PMGIFSILEEECMFPKATDTSFKNKLYDQ-HLGKSNNFQKPKVvkgrAEAHFSLIHYA 584
Cdd:COG5022    480 EWSFIDY-FDNQPCIDLIEKknPLGILSLLDEECVMPHATDESFTSKLAQRlNKNSNPKFKKSRF----RDNKFVVKHYA 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  585 GTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYatfatadadsgKKKVAKKKGSSFQTVSALFRENLNKLMSNLR 664
Cdd:COG5022    555 GDVEYDVEGFLDKNKDPLNDDLLELLKASTNEFVSTLF-----------DDEENIESKGRFPTLGSRFKESLNSLMSTLN 623
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  665 TTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFI---DSKK 741
Cdd:COG5022    624 STQPHYIRCIKPNEEKSPWTFDNQMVLSQLRCCGVLETIRISRAGFPSRWTFDEFVQRYRILSPSKSWTGEYTwkeDTKN 703
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  742 ACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNIRS 821
Cdd:COG5022    704 AVKSILEELVIDSSKYQIGNTKVFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRYLQALKRIKKIQVIQHGFRL 783
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  822 FMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELaKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 901
Cdd:COG5022    784 RRLVDYELKWRLFIKLQPLLSLLGSRKEYRSYLACIIKLQKTI-KREKKLRETEEVEFSLKAEVLIQKFGRSLKAKKRFS 862
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  902 AEERCDQLIKAKFQLEAKIKEVTERAEDEEEINaELTAKKRKLEDECSELKKDIDDLELtlakvekekhateNKVKNLTE 981
Cdd:COG5022    863 LLKKETIYLQSAQRVELAERQLQELKIDVKSIS-SLKLVNLELESEIIELKKSLSSDLI-------------ENLEFKTE 928
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  982 ELSGLDETIAKLTREKKALQEAHQQalddlqaeeDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLK 1061
Cdd:COG5022    929 LIARLKKLLNNIDLEEGPSIEYVKL---------PELNKLHEVESKLKETSEEYEDLLKKSTILVREGNKANSELKNFKK 999
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462555497 1062 LAQEsILDLENDKQQLDERLKKKDFEYCQLQS--KVEDEQTLGLQFQKKIKEL 1112
Cdd:COG5022   1000 ELAE-LSKQYGALQESTKQLKELPVEVAELQSasKIISSESTELSILKPLQKL 1051
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
847-1924 1.11e-155

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 508.95  E-value: 1.11e-155
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTER 926
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESR 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  927 AEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQ 1006
Cdd:pfam01576   84 LEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERISE 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1007 ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDF 1086
Cdd:pfam01576  164 FTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEE 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1087 EYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK 1166
Cdd:pfam01576  244 ELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRS 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1167 KREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANL 1246
Cdd:pfam01576  324 KREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDS 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1247 EKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKA 1326
Cdd:pfam01576  404 EHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQ 483
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1327 KNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAiQRTEELEEAKKKLAQRLQDSEEQVE 1406
Cdd:pfam01576  484 KLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDA-GTLEALEEGKKRLQRELEALTQQLE 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1407 AVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKC-----EESQAELEASLKESRSLSte 1481
Cdd:pfam01576  563 EKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISaryaeERDRAEAEAREKETRALS-- 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1482 lfkLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILR 1561
Cdd:pfam01576  641 ---LARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLR 717
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1562 IQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETL 1641
Cdd:pfam01576  718 LEVNMQALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAV 797
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1642 KHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQN 1721
Cdd:pfam01576  798 KQLKKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGASGK 877
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1722 TSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA 1801
Cdd:pfam01576  878 SALQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEM 957
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1802 EQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKR 1881
Cdd:pfam01576  958 EGTVKSKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKR 1037
                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|...
gi 2462555497 1882 QAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAK 1924
Cdd:pfam01576 1038 QLEEAEEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
PTZ00014 PTZ00014
myosin-A; Provisional
62-826 2.27e-138

myosin-A; Provisional


Pssm-ID: 240229 [Multi-domain]  Cd Length: 821  Bit Score: 452.56  E-value: 2.27e-138
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   62 VETEDNRTLVVKPEDVYAMNPP-KFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVV 140
Cdd:PTZ00014    71 IDPPTNSTFEVKPEHAFNANSQiDPMTYGDIGLLPHTNIPCVLDFLKHRYLKNQIYTTADPLLVAINPFKDLGNTTNDWI 150
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  141 EGYR-GKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATiAATGDlakkkdskMKGTLED 219
Cdd:PTZ00014   151 RRYRdAKDSDKLPPHVFTTARRALENLHGVKKSQTIIVSGESGAGKTEATKQIMRYFAS-SKSGN--------MDLKIQN 221
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  220 QIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELI 299
Cdd:PTZ00014   222 AIMAANPVLEAFGNAKTIRNNNSSRFGRFMQLQLGEEGGIRYGSIVAFLLEKSRVVTQEDDERSYHIFYQLLKGANDEMK 301
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  300 ELLLItTNPYDYPFISQGEILVASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAE---- 375
Cdd:PTZ00014   302 EKYKL-KSLEEYKYINPKCLDVPGIDDVKDFEEVMESFDSMGLSESQIEDIFSILSGVLLLGNVEIEGKEEGGLTDaaai 380
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  376 -PDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPR 454
Cdd:PTZ00014   381 sDESLEVFNEACELLFLDYESLKKELTVKVTYAGNQKIEGPWSKDESEMLKDSLSKAVYEKLFLWIIRNLNATIEPPGGF 460
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  455 QHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGI-----EWTfidfgmDLAACIELI-EKP 528
Cdd:PTZ00014   461 KVFIGMLDIFGFEVFKNNSLEQLFINITNEMLQKNFVDIVFERESKLYKDEGIsteelEYT------SNESVIDLLcGKG 534
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  529 MGIFSILEEECMFPKATDTSFKNKLYDQHlgKSNNFQKPKVVKGRAEahFSLIHYAGTVDYSVSGWLEKNKDPLNETVVG 608
Cdd:PTZ00014   535 KSVLSILEDQCLAPGGTDEKFVSSCNTNL--KNNPKYKPAKVDSNKN--FVIKHTIGDIQYCASGFLFKNKDVLRPELVE 610
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  609 LYQKSSNRLLAHLyatFATADADSGKKKVAKKKGSSFQtvsalfrENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHS 688
Cdd:PTZ00014   611 VVKASPNPLVRDL---FEGVEVEKGKLAKGQLIGSQFL-------NQLDSLMSLINSTEPHFIRCIKPNENKKPLDWNSS 680
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  689 LVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNAsAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKA 768
Cdd:PTZ00014   681 KVLIQLHSLSILEALQLRQLGFSYRRTFAEFLSQFKYLDL-AVSNDSSLDPKEKAEKLLERSGLPKDSYAIGKTMVFLKK 759
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462555497  769 GLLGTLEEMRDDRLAK---LITRTQAVCRGFLMRVEFQKMVQrreSIFCIQYNIRSFMNVK 826
Cdd:PTZ00014   760 DAAKELTQIQREKLAAwepLVSVLEALILKIKKKRKVRKNIK---SLVRIQAHLRRHLVIA 817
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1173-1928 4.05e-28

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 124.40  E-value: 4.05e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1173 LKLRRDLEEATLQHEAMVATLrKKHADSVAELGEQIDNLQRVKQKLEK-----------EKSEFKLEIDDLSSSMESVSK 1241
Cdd:TIGR02168  168 SKYKERRKETERKLERTRENL-DRLEDILNELERQLKSLERQAEKAERykelkaelrelELALLVLRLEELREELEELQE 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1242 SKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLE 1321
Cdd:TIGR02168  247 ELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLE 326
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1322 EENKAKNALAHALQSsrhdcdlLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETdaiqRTEELEEAKKKLAQRlqds 1401
Cdd:TIGR02168  327 ELESKLDELAEELAE-------LEEKLEELKEELESLEAELEELEAELEELESRLEE----LEEQLETLRSKVAQL---- 391
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1402 EEQVEAVNAKCASLEKTKQRLQGEVEDLmvdVERANSLAAALDKKQrnfdkvLAEWKTKCEESQAELEASLKESRSLSTE 1481
Cdd:TIGR02168  392 ELQIASLNNEIERLEARLERLEDRRERL---QQEIEELLKKLEEAE------LKELQAELEELEEELEELQEELERLEEA 462
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1482 LFKLKNAYEEALDQLETVKRENKNLEQEIA---DLTEQIAENGKTIHELEKSRKQI---------------ELEKADIQL 1543
Cdd:TIGR02168  463 LEELREELEEAEQALDAAERELAQLQARLDsleRLQENLEGFSEGVKALLKNQSGLsgilgvlselisvdeGYEAAIEAA 542
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1544 ALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDL 1623
Cdd:TIGR02168  543 LGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLL 622
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1624 NEIEI--QLSHANRQAAETLKHLRSVQgqLKDTQLHLDDALRGQEDlKEQLAIVERRANL--LQAEVEELRATLEQTERA 1699
Cdd:TIGR02168  623 GGVLVvdDLDNALELAKKLRPGYRIVT--LDGDLVRPGGVITGGSA-KTNSSILERRREIeeLEEKIEELEEKIAELEKA 699
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1700 RKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1779
Cdd:TIGR02168  700 LAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAE 779
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1780 LERMKKNLEQTVKDLQhrldeaeqlalkggkKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDR 1859
Cdd:TIGR02168  780 AEAEIEELEAQIEQLK---------------EELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLE 844
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462555497 1860 KNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDF 1928
Cdd:TIGR02168  845 EQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSEL 913
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
840-1453 2.69e-26

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 118.12  E-value: 2.69e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  840 LLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAK 919
Cdd:COG1196    231 LLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER 310
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  920 IKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKA 999
Cdd:COG1196    311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1000 LQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDE 1079
Cdd:COG1196    391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLE 470
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1080 RLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQ--RSDYARELEELSERLEEAGGV 1157
Cdd:COG1196    471 EAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAvlIGVEAAYEAALEAALAAALQN 550
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1158 TSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRvkqkLEKEKSEFKLEIDDLSSSME 1237
Cdd:COG1196    551 IVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVAS----DLREADARYYVLGDTLLGRT 626
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1238 SVSKSKANLEKICRTLEDQLSEARGKNEEIQRSlselttqKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELK 1317
Cdd:COG1196    627 LVAARLEAALRRAVTLAGRLREVTLEGEGGSAG-------GSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEAL 699
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1318 RQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAqwrtKYETDAIQRTEELEEAKKKLAQR 1397
Cdd:COG1196    700 LAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEA----LEELPEPPDLEELERELERLERE 775
                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462555497 1398 LQD-------SEEQVEAVNAKCASLEKTKQRLQGEVEDLM-----VDVERANSLAAALDKKQRNFDKV 1453
Cdd:COG1196    776 IEAlgpvnllAIEEYEELEERYDFLSEQREDLEEARETLEeaieeIDRETRERFLETFDAVNENFQEL 843
PTZ00121 PTZ00121
MAEBL; Provisional
831-1435 4.64e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 91.74  E-value: 4.64e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  831 MKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDlQLQVQAEsENLLDAEERCDQLI 910
Cdd:PTZ00121  1262 MAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKAD-EAKKKAE-EAKKKADAAKKKAE 1339
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  911 KAKFQLEAKIKEvTERAEDEEEINAEltaKKRKLEDECSELKKDIDDLEltlAKVEKEKHATENKVKnlTEELSGLDETI 990
Cdd:PTZ00121  1340 EAKKAAEAAKAE-AEAAADEAEAAEE---KAEAAEKKKEEAKKKADAAK---KKAEEKKKADEAKKK--AEEDKKKADEL 1410
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  991 AKLTREKKALQEAHQQALDDLQAEEdkvnslNKTKSKLEQQVEDLESSLEQEKKlrvdLERNKRKLEgDLKLAQESILDL 1070
Cdd:PTZ00121  1411 KKAAAAKKKADEAKKKAEEKKKADE------AKKKAEEAKKADEAKKKAEEAKK----AEEAKKKAE-EAKKADEAKKKA 1479
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1071 ENDKQQldERLKKKDFEycqlQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEaeratRAKTEKQRSDYARELEELSER 1150
Cdd:PTZ00121  1480 EEAKKA--DEAKKKAEE----AKKKADEAKKAAEAKKKADEAKKAEEAKKADEA-----KKAEEAKKADEAKKAEEKKKA 1548
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1151 LeeaggvtstqiELNKKREAEFLKLRRDLEEATLQHEAMVATLRKkhadsvAELGEQIdnlqrvkqklEKEKSEFKLEID 1230
Cdd:PTZ00121  1549 D-----------ELKKAEELKKAEEKKKAEEAKKAEEDKNMALRK------AEEAKKA----------EEARIEEVMKLY 1601
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1231 DLSSSMESVSKSKANLEKIcrtledqLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFT 1310
Cdd:PTZ00121  1602 EEEKKMKAEEAKKAEEAKI-------KAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDK 1674
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1311 QQTEELKRQLEEENKAKNALAHALQSSRhDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAiQRTEEL--- 1387
Cdd:PTZ00121  1675 KKAEEAKKAEEDEKKAAEALKKEAEEAK-KAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDK-KKAEEAkkd 1752
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*...
gi 2462555497 1388 EEAKKKLAQRLQDSEEQVEAVNAKCASLekTKQRLQGEVEDLMVDVER 1435
Cdd:PTZ00121  1753 EEEKKKIAHLKKEEEKKAEEIRKEKEAV--IEEELDEEDEKRRMEVDK 1798
Myosin_N pfam02736
Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the ...
33-77 6.62e-12

Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.


Pssm-ID: 460670  Cd Length: 45  Bit Score: 61.68  E-value: 6.62e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462555497   33 DAKTYCFVVDSKEEYAKGKIKSSQDGKVTVETEDNRTLVVKPEDV 77
Cdd:pfam02736    1 DAKKLVWVPDPKEGFVKGEIKEEEGDKVTVETEDGKTVTVKKDDV 45
growth_prot_Scy NF041483
polarized growth protein Scy;
1254-1923 6.40e-04

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 44.82  E-value: 6.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1254 EDQLSEARGKNEEIQRSLSELTtqkSRLQTEAGELSRQLEekesivsqlsrskqaftQQTEELKRQLEEENKAKNALAHA 1333
Cdd:NF041483   592 EEALADARAEAERIRREAAEET---ERLRTEAAERIRTLQ-----------------AQAEQEAERLRTEAAADASAARA 651
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1334 lQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAiqrTEELEEAKKKLAQRLQDSEEQVEAVNAKcA 1413
Cdd:NF041483   652 -EGENVAVRLRSEAAAEAERLKSEAQESADRVRAEAAAAAERVGTEA---AEALAAAQEEAARRRREAEETLGSARAE-A 726
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1414 SLEKTKQRLQGEvedlmvdveranslaaaldkkqrnfdKVLAEWKTKCEESQAELEASLKESRSLSTELfkLKNAYEEAL 1493
Cdd:NF041483   727 DQERERAREQSE--------------------------ELLASARKRVEEAQAEAQRLVEEADRRATEL--VSAAEQTAQ 778
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1494 DQLETVKRENKNLEQEIADLtEQIAEngktiHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILR-IQLELTQVKSE 1572
Cdd:NF041483   779 QVRDSVAGLQEQAEEEIAGL-RSAAE-----HAAERTRTEAQEEADRVRSDAYAERERASEDANRLRReAQEETEAAKAL 852
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1573 IDRKIAEKDEEIEQLKRNYQRTVETMQS-ALDAEVRSRNEAIRLKKKMEGDLNEI--------EIQLSHANRQAAETLKH 1643
Cdd:NF041483   853 AERTVSEAIAEAERLRSDASEYAQRVRTeASDTLASAEQDAARTRADAREDANRIrsdaaaqaDRLIGEATSEAERLTAE 932
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1644 LRSVQGQLKDTQLHLDDALRGqedlkEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTS 1723
Cdd:NF041483   933 ARAEAERLRDEARAEAERVRA-----DAAAQAEQLIAEATGEAERLRAEAAETVGSAQQHAERIRTEAERVKAEAAAEAE 1007
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1724 LIHTKKKLETDLMqLQSEVEDASRDARNAEEKAKKAITDAAMMAEEL---------KKEQDTSAHLERM----KKNLEQT 1790
Cdd:NF041483  1008 RLRTEAREEADRT-LDEARKDANKRRSEAAEQADTLITEAAAEADQLtakaqeealRTTTEAEAQADTMvgaaRKEAERI 1086
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1791 VKDL---------QHRLDEAEQLAlkGGKKQIQKLETRIRELEFELEGE-----QKKNTESVKGLRKYERRVKELTYQSE 1856
Cdd:NF041483  1087 VAEAtvegnslveKARTDADELLV--GARRDATAIRERAEELRDRITGEieelhERARRESAEQMKSAGERCDALVKAAE 1164
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462555497 1857 EDRKnvlrlqdlvdklQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRA 1923
Cdd:NF041483  1165 EQLA------------EAEAKAKELVSDANSEASKVRIAAVKKAEGLLKEAEQKKAELVREAEKIKA 1219
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
926-1051 7.48e-04

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 43.90  E-value: 7.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  926 RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETI-AKLTREKKALQeah 1004
Cdd:cd22656    101 DDLADATDDEELEEAKKTIKALLDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQTALETLEKALkDLLTDEGGAIA--- 177
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462555497 1005 QQALDDLQAEEDKVN-----SLNKTKSKLEQQVEDLESSLEQEKKLRVDLER 1051
Cdd:cd22656    178 RKEIKDLQKELEKLNeeyaaKLKAKIDELKALIADDEAKLAAALRLIADLTA 229
COG6 smart01087
Conserved oligomeric complex COG6; COG6 is a component of the conserved oligomeric golgi ...
1373-1506 2.01e-03

Conserved oligomeric complex COG6; COG6 is a component of the conserved oligomeric golgi complex, which is composed of eight different subunits and is required for normal golgi morphology and localisation.


Pssm-ID: 215018  Cd Length: 598  Bit Score: 43.08  E-value: 2.01e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  1373 RTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQrnfdK 1452
Cdd:smart01087    9 RSDLEKRLLKINGEFLSEFKPVAEQLQRLSEDVQKLNNSCDSMKDQLNTAKNQTQDLISEASELQEELALLELKK----K 84
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2462555497  1453 VLAEWKTKCEESQAELEASLKESRSLSTELFKlknayeeALDQLETVKRENKNL 1506
Cdd:smart01087   85 LLDAFLSKFTLSQDELDVLTSREGPIDDEFFQ-------VLDKVQEIHEDCSVL 131
growth_prot_Scy NF041483
polarized growth protein Scy;
1244-1926 5.09e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 42.12  E-value: 5.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1244 ANLEKICRTLEDQLSEA--------RGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKqafTQQTEE 1315
Cdd:NF041483   364 AQLAKAARTAEEVLTKAsedakattRAAAEEAERIRREAEAEADRLRGEAADQAEQLKGAAKDDTKEYRAK---TVELQE 440
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1316 LKRQLEEENKAKNALAHAlQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQ-RTEELEEA---K 1391
Cdd:NF041483   441 EARRLRGEAEQLRAEAVA-EGERIRGEARREAVQQIEEAARTAEELLTKAKADADELRSTATAESERvRTEAIERAttlR 519
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1392 KKLAQRLQDSEEQVEAVNAKCASL-EKTKQRLQGEVEDLMVDVERanslaaALDKKQRNFDKVLAEWKTKCEESQAELEA 1470
Cdd:NF041483   520 RQAEETLERTRAEAERLRAEAEEQaEEVRAAAERAARELREETER------AIAARQAEAAEELTRLHTEAEERLTAAEE 593
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1471 SLKESRSLSTELFKlknayeEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQ---LALEE 1547
Cdd:NF041483   594 ALADARAEAERIRR------EAAEETERLRTEAAERIRTLQAQAEQEAERLRTEAAADASAARAEGENVAVRlrsEAAAE 667
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1548 AEAALEHEEAKILRIQLELT----QVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE-VRSRNEAIRL----KKK 1618
Cdd:NF041483   668 AERLKSEAQESADRVRAEAAaaaeRVGTEAAEALAAAQEEAARRRREAEETLGSARAEADQErERAREQSEELlasaRKR 747
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1619 MEGDLNEIEIQLSHANRQAAETL----KHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAivERRANLLQAEVEELRA--- 1691
Cdd:NF041483   748 VEEAQAEAQRLVEEADRRATELVsaaeQTAQQVRDSVAGLQEQAEEEIAGLRSAAEHAA--ERTRTEAQEEADRVRSday 825
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1692 ----------------TLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLmqLQSEVEDASRDARNAEEK 1755
Cdd:NF041483   826 aererasedanrlrreAQEETEAAKALAERTVSEAIAEAERLRSDASEYAQRVRTEASDT--LASAEQDAARTRADARED 903
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1756 AKKAITDAAMMAEELKKEQDTSAHLERmkknlEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNT 1835
Cdd:NF041483   904 ANRIRSDAAAQADRLIGEATSEAERLT-----AEARAEAERLRDEARAEAERVRADAAAQAEQLIAEATGEAERLRAEAA 978
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1836 ESVKG-------LRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEAdEQANAHLTKFRKAQHEL---- 1904
Cdd:NF041483   979 ETVGSaqqhaerIRTEAERVKAEAAAEAERLRTEAREEADRTLDEARKDANKRRSEAA-EQADTLITEAAAEADQLtaka 1057
                          730       740
                   ....*....|....*....|...
gi 2462555497 1905 -EEAEERADIAESQVNKLRAKTR 1926
Cdd:NF041483  1058 qEEALRTTTEAEAQADTMVGAAR 1080
 
Name Accession Description Interval E-value
MYSc_Myh3 cd14913
class II myosin heavy chain 3, motor domain; Myosin motor domain of fetal skeletal muscle ...
100-767 0e+00

class II myosin heavy chain 3, motor domain; Myosin motor domain of fetal skeletal muscle myosin heavy chain 3 (MYHC-EMB, MYHSE1, HEMHC, SMHCE) in tetrapods including mammals, lizards, and frogs. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. Mutations in this gene have been associated with two congenital contracture (arthrogryposis) syndromes, Freeman-Sheldon syndrome and Sheldon-Hall syndrome. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276878 [Multi-domain]  Cd Length: 668  Bit Score: 1447.94  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14913      1 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 259
Cdd:cd14913     81 ESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  260 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDI 339
Cdd:cd14913    161 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  340 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVD 419
Cdd:cd14913    241 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVD 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  420 QVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQ 499
Cdd:cd14913    321 QVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQ 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  500 EEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFS 579
Cdd:cd14913    401 EEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFS 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  580 LIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKL 659
Cdd:cd14913    481 LIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKL 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  660 MSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDS 739
Cdd:cd14913    561 MSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDS 640
                          650       660
                   ....*....|....*....|....*...
gi 2462555497  740 KKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14913    641 KKACEKLLASIDIDHTQYKFGHTKVFFK 668
MYSc_class_II cd01377
class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, ...
100-767 0e+00

class II myosins, motor domain; Myosin motor domain in class II myosins. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. Thus, myosin II has two heads. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276951 [Multi-domain]  Cd Length: 662  Bit Score: 1326.71  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd01377      1 ASVLHNLRERYYSDLIYTYSGLFCVAVNPYKRLPIYTEEVIDKYKGKRREEMPPHIFAIADNAYRNMLQDRENQSILITG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGDlAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 259
Cdd:cd01377     81 ESGAGKTENTKKVIQYLASVAASSK-KKKESGKKKGTLEDQILQANPILEAFGNAKTVRNNNSSRFGKFIRIHFGSTGKI 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  260 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDI 339
Cdd:cd01377    160 AGADIETYLLEKSRVVRQAKGERNYHIFYQLLSGADPELKEKLLLTGDPSYYFFLSQGELTIDGVDDAEEFKLTDEAFDI 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  340 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVD 419
Cdd:cd01377    240 LGFSEEEKMSIFKIVAAILHLGNIKFKQRRREEQAELDGTEEADKAAHLLGVNSSDLLKALLKPRIKVGREWVTKGQNKE 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  420 QVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQ 499
Cdd:cd01377    320 QVVFSVGALAKALYERLFLWLVKRINKTLDTKSKRQYFIGVLDIAGFEIFEFNSFEQLCINYTNEKLQQFFNHHMFVLEQ 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  500 EEYKKEGIEWTFIDFGMDLAACIELIEKP-MGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKvvKGRAEAHF 578
Cdd:cd01377    400 EEYKKEGIEWTFIDFGLDLQPTIDLIEKPnMGILSILDEECVFPKATDKTFVEKLYSNHLGKSKNFKKPK--PKKSEAHF 477
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  579 SLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLyatFATADADSGKKKVAKKKGSSFQTVSALFRENLNK 658
Cdd:cd01377    478 ILKHYAGDVEYNIDGWLEKNKDPLNENVVALLKKSSDPLVASL---FKDYEESGGGGGKKKKKGGSFRTVSQLHKEQLNK 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  659 LMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFiD 738
Cdd:cd01377    555 LMTTLRSTHPHFVRCIIPNEEKKPGKIDAPLVLHQLRCNGVLEGIRICRKGFPNRIIFAEFKQRYSILAPNAIPKGFD-D 633
                          650       660
                   ....*....|....*....|....*....
gi 2462555497  739 SKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd01377    634 GKAACEKILKALQLDPELYRIGNTKVFFK 662
MYSc_Myh8 cd14918
class II myosin heavy chain 8, motor domain; Myosin motor domain of perinatal skeletal muscle ...
100-767 0e+00

class II myosin heavy chain 8, motor domain; Myosin motor domain of perinatal skeletal muscle myosin heavy chain 8 (also called MyHC-peri, MyHC-pn). Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276882 [Multi-domain]  Cd Length: 668  Bit Score: 1219.58  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14918      1 PGVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 259
Cdd:cd14918     81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEESGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  260 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDI 339
Cdd:cd14918    161 ASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIDI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  340 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVD 419
Cdd:cd14918    241 LGFTPEEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQTVQ 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  420 QVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQ 499
Cdd:cd14918    321 QVYNAVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQ 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  500 EEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFS 579
Cdd:cd14918    401 EEYKKEGIEWTFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYDQHLGKSANFQKPKVVKGKAEAHFS 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  580 LIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKL 659
Cdd:cd14918    481 LIHYAGTVDYNITGWLDKNKDPLNDTVVGLYQKSAMKTLASLFSTYASAEADSGAKKGAKKKGSSFQTVSALFRENLNKL 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  660 MSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDS 739
Cdd:cd14918    561 MTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFIDS 640
                          650       660
                   ....*....|....*....|....*...
gi 2462555497  740 KKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14918    641 KKASEKLLASIDIDHTQYKFGHTKVFFK 668
MYSc_Myh13 cd14923
class II myosin heavy chain 13, motor domain; Myosin motor domain of skeletal muscle myosin ...
100-767 0e+00

class II myosin heavy chain 13, motor domain; Myosin motor domain of skeletal muscle myosin heavy chain 13 (also called MyHC-eo) in mammals, chicken, and green anole. Myh13 is a myosin whose expression is restricted primarily to the extrinsic eye muscles which are specialized for function in eye movement. Class II myosins, also called conventional myosins, are the myosin type responsible for producing muscle contraction in muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276887 [Multi-domain]  Cd Length: 671  Bit Score: 1199.50  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14923      1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGDLAKKKD-SKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 258
Cdd:cd14923     81 ESGAGKTVNTKRVIQYFATIAVTGDKKKEQQpGKMQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  259 LASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAID 338
Cdd:cd14923    161 LASADIETYLLEKSRVTFQLSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAID 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  339 ILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTV 418
Cdd:cd14923    241 ILGFSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNV 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  419 DQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLE 498
Cdd:cd14923    321 QQVTNSVGALAKAVYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLE 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  499 QEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHF 578
Cdd:cd14923    401 QEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAHF 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  579 SLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADA--DSGKKKVAKKKGSSFQTVSALFRENL 656
Cdd:cd14923    481 SLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSLKLLSFLFSNYAGAEAgdSGGSKKGGKKKGSSFQTVSAVFRENL 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  657 NKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQF 736
Cdd:cd14923    561 NKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYRILNASAIPEGQF 640
                          650       660       670
                   ....*....|....*....|....*....|.
gi 2462555497  737 IDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14923    641 IDSKNASEKLLNSIDVDREQYRFGHTKVFFK 671
MYSc_Myh2_mammals cd14912
class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle ...
100-767 0e+00

class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle myosin heavy chain 2 (also called MYH2A, MYHSA2, MyHC-IIa, MYHas8, MyHC-2A) in mammals. Mutations in this gene results in inclusion body myopathy-3 and familial congenital myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276877 [Multi-domain]  Cd Length: 673  Bit Score: 1193.00  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14912      1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGDLAKKK--DSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 257
Cdd:cd14912     81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEitSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  258 KLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAI 337
Cdd:cd14912    161 KLASADIETYLLEKSRVTFQLKAERSYHIFYQITSNKKPELIEMLLITTNPYDYPFVSQGEISVASIDDQEELMATDSAI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  338 DILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQT 417
Cdd:cd14912    241 DILGFTNEEKVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQT 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  418 VDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVL 497
Cdd:cd14912    321 VEQVTNAVGALAKAVYEKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  498 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAH 577
Cdd:cd14912    401 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVKGKAEAH 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  578 FSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATAD---ADSGKKKVAKKKGSSFQTVSALFRE 654
Cdd:cd14912    481 FSLIHYAGVVDYNITGWLDKNKDPLNETVVGLYQKSAMKTLAYLFSGAQTAEgasAGGGAKKGGKKKGSSFQTVSALFRE 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  655 NLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEG 734
Cdd:cd14912    561 NLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEG 640
                          650       660       670
                   ....*....|....*....|....*....|...
gi 2462555497  735 QFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14912    641 QFIDSKKASEKLLASIDIDHTQYKFGHTKVFFK 673
MYSc_Myh1_mammals cd14910
class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle ...
100-767 0e+00

class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle myosin heavy chain 1 (also called MYHSA1, MYHa, MyHC-2X/D, MGC133384) in mammals. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276875 [Multi-domain]  Cd Length: 671  Bit Score: 1189.92  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14910      1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGDLAKKK--DSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 257
Cdd:cd14910     81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEatSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  258 KLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAI 337
Cdd:cd14910    161 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  338 DILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQT 417
Cdd:cd14910    241 EILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYVTKGQT 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  418 VDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVL 497
Cdd:cd14910    321 VQQVYNAVGALAKAVYDKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  498 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAH 577
Cdd:cd14910    401 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKVEAH 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  578 FSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADS-GKKKVAKKKGSSFQTVSALFRENL 656
Cdd:cd14910    481 FSLIHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSSMKTLALLFSGAAAAEAEEgGGKKGGKKKGSSFQTVSALFRENL 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  657 NKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQF 736
Cdd:cd14910    561 NKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQF 640
                          650       660       670
                   ....*....|....*....|....*....|.
gi 2462555497  737 IDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14910    641 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 671
MYSc_Myh4 cd14915
class II myosin heavy chain 4, motor domain; Myosin motor domain of skeletal muscle myosin ...
100-767 0e+00

class II myosin heavy chain 4, motor domain; Myosin motor domain of skeletal muscle myosin heavy chain 4 (also called MYH2B, MyHC-2B, MyHC-IIb). Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276879 [Multi-domain]  Cd Length: 671  Bit Score: 1186.84  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14915      1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGDLAKKKDS--KMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 257
Cdd:cd14915     81 ESGAGKTVNTKRVIQYFATIAVTGEKKKEEAAsgKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATG 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  258 KLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAI 337
Cdd:cd14915    161 KLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPELIEMLLITTNPYDFAFVSQGEITVPSIDDQEELMATDSAV 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  338 DILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQT 417
Cdd:cd14915    241 DILGFSADEKVAIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLTSLNSADLLKALCYPRVKVGNEYVTKGQT 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  418 VDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVL 497
Cdd:cd14915    321 VQQVYNSVGALAKAIYEKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVL 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  498 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAH 577
Cdd:cd14915    401 EQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKAEAH 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  578 FSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADAD-SGKKKVAKKKGSSFQTVSALFRENL 656
Cdd:cd14915    481 FSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSGMKTLAFLFSGGQTAEAEgGGGKKGGKKKGSSFQTVSALFRENL 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  657 NKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQF 736
Cdd:cd14915    561 NKLMTNLRSTHPHFVRCLIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQF 640
                          650       660       670
                   ....*....|....*....|....*....|.
gi 2462555497  737 IDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14915    641 IDSKKASEKLLGSIDIDHTQYKFGHTKVFFK 671
MYSc_Myh7b cd14927
class II myosin heavy chain 7b, motor domain; Myosin motor domain of cardiac muscle, beta ...
101-767 0e+00

class II myosin heavy chain 7b, motor domain; Myosin motor domain of cardiac muscle, beta myosin heavy chain 7b (also called KIAA1512, dJ756N5.1, MYH14, MHC14). MYH7B is a slow-twitch myosin. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276953 [Multi-domain]  Cd Length: 676  Bit Score: 1164.33  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 180
Cdd:cd14927      2 SVLHNLRRRYSRWMIYTYSGLFCVTVNPYKWLPVYTAPVVAAYKGKRRSEAPPHIYAIADNAYNDMLRNRENQSMLITGE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  181 SGAGKTVNTKRVIQYFATIAATGDLAKKKD----SKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTT 256
Cdd:cd14927     82 SGAGKTVNTKRVIQYFAIVAALGDGPGKKAqflaTKTGGTLEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPT 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  257 GKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSA 336
Cdd:cd14927    162 GKLASADIDIYLLEKSRVIFQQPGERSYHIYYQILSGKKPELQDMLLVSMNPYDYHFCSQGVTTVDNMDDGEELMATDHA 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  337 IDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQ 416
Cdd:cd14927    242 MDILGFSPDEKYGCYKIVGAIMHFGNMKFKQKQREEQAEADGTESADKAAYLMGVSSADLLKGLLHPRVKVGNEYVTKGQ 321
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  417 TVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFV 496
Cdd:cd14927    322 SVEQVVYAVGALAKATYDRMFKWLVSRINQTLDTKLPRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMFI 401
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  497 LEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRA-E 575
Cdd:cd14927    402 LEQEEYKREGIEWVFIDFGLDLQACIDLIEKPLGILSILEEECMFPKASDASFKAKLYDNHLGKSPNFQKPRPDKKRKyE 481
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  576 AHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADS---GKKKVAKKKGSSFQTVSALF 652
Cdd:cd14927    482 AHFEVVHYAGVVPYNIVGWLDKNKDPLNETVVAIFQKSQNKLLATLYENYVGSDSTEdpkSGVKEKRKKAASFQTVSQLH 561
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  653 RENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIP 732
Cdd:cd14927    562 KENLNKLMTNLRATQPHFVRCIIPNETKTPGVMDPFLVLHQLRCNGVLEGIRICRKGFPNRILYADFKQRYRILNPSAIP 641
                          650       660       670
                   ....*....|....*....|....*....|....*
gi 2462555497  733 EGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14927    642 DDKFVDSRKATEKLLGSLDIDHTQYQFGHTKVFFK 676
MYSc_Myh7 cd14917
class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I ...
100-767 0e+00

class II myosin heavy chain 7, motor domain; Myosin motor domain of beta (or slow) type I cardiac muscle myosin heavy chain 7 (also called CMH1, MPD1, and CMD1S). Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. It is expressed predominantly in normal human ventrical and in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276881 [Multi-domain]  Cd Length: 668  Bit Score: 1156.39  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14917      1 PAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 259
Cdd:cd14917     81 ESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  260 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDI 339
Cdd:cd14917    161 ASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDV 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  340 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVD 419
Cdd:cd14917    241 LGFTSEEKNSMYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQ 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  420 QVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQ 499
Cdd:cd14917    321 QVIYATGALAKAVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQ 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  500 EEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFS 579
Cdd:cd14917    401 EEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLFDNHLGKSNNFQKPRNIKGKPEAHFS 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  580 LIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKL 659
Cdd:cd14917    481 LIHYAGTVDYNIIGWLQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPIEKGKGKAKKGSSFQTVSALHRENLNKL 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  660 MSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDS 739
Cdd:cd14917    561 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDS 640
                          650       660
                   ....*....|....*....|....*...
gi 2462555497  740 KKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14917    641 RKGAEKLLSSLDIDHNQYKFGHTKVFFK 668
MYSc_Myh6 cd14916
class II myosin heavy chain 6, motor domain; Myosin motor domain of alpha (or fast) cardiac ...
100-767 0e+00

class II myosin heavy chain 6, motor domain; Myosin motor domain of alpha (or fast) cardiac muscle myosin heavy chain 6. Cardiac muscle myosin is a hexamer consisting of two heavy chain subunits, two light chain subunits, and two regulatory subunits. This gene encodes the alpha heavy chain subunit of cardiac myosin. Mutations in this gene cause familial hypertrophic cardiomyopathy and atrial septal defect. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276880 [Multi-domain]  Cd Length: 670  Bit Score: 1143.25  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14916      1 PAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKM-KGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 258
Cdd:cd14916     81 ESGAGKTVNTKRVIQYFASIAAIGDRSKKENPNAnKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGK 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  259 LASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAID 338
Cdd:cd14916    161 LASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEVSVASIDDSEELLATDSAFD 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  339 ILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTV 418
Cdd:cd14916    241 VLGFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSV 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  419 DQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLE 498
Cdd:cd14916    321 QQVYYSIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLE 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  499 QEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHF 578
Cdd:cd14916    401 QEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHF 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  579 SLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADA-DSGKKKVAKKKGSSFQTVSALFRENLN 657
Cdd:cd14916    481 SLVHYAGTVDYNILGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTgDSGKGKGGKKKGSSFQTVSALHRENLN 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  658 KLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFI 737
Cdd:cd14916    561 KLMTNLKTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFI 640
                          650       660       670
                   ....*....|....*....|....*....|
gi 2462555497  738 DSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14916    641 DSRKGAEKLLGSLDIDHNQYKFGHTKVFFK 670
MYSc_Myh15_mammals cd14929
class II myosin heavy chain 15, motor domain; Myosin motor domain of sarcomeric myosin heavy ...
100-767 0e+00

class II myosin heavy chain 15, motor domain; Myosin motor domain of sarcomeric myosin heavy chain 15 in mammals (also called KIAA1000) . MYH15 is a slow-twitch myosin. Myh15 is a ventricular myosin heavy chain. Myh15 is absent in embryonic and fetal muscles and is found in orbital layer of extraocular muscles at birth. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276892 [Multi-domain]  Cd Length: 662  Bit Score: 1044.56  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14929      1 ASVLHTLRRRYDHWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNAFQDMLHNRENQSILFTG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGDLAKKKdskmkGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 259
Cdd:cd14929     81 ESGAGKTVNTKHIIQYFATIAAMIESKKKL-----GALEDQIMQANPVLEAFGNAKTLRNDNSSRFGKFIRMHFGARGML 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  260 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKpELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDI 339
Cdd:cd14929    156 SSADIDIYLLEKSRVIFQQPGERNYHIFYQILSGKK-ELRDLLLVSANPSDFHFCSCGAVAVESLDDAEELLATEQAMDI 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  340 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVD 419
Cdd:cd14929    235 LGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQLEADGTENADKAAFLMGINSSELVKGLIHPRIKVGNEYVTRSQNIE 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  420 QVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQ 499
Cdd:cd14929    315 QVTYAVGALSKSIYERMFKWLVARINRVLDAKLSRQFFIGILDITGFEILDYNSLEQLCINFTNEKLQQFFNQHMFVLEQ 394
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  500 EEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFS 579
Cdd:cd14929    395 EEYRKEGIDWVSIDFGLDLQACIDLIEKPMGIFSILEEECMFPKATDLTFKTKLFDNHFGKSVHFQKPKPDKKKFEAHFE 474
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  580 LIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKL 659
Cdd:cd14929    475 LVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFENYISTDSAIQFGEKKRKKGASFQTVASLHKENLNKL 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  660 MSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFIDS 739
Cdd:cd14929    555 MTNLKSTAPHFVRCINPNVNKIPGVLDPYLVLQQLRCNGVLEGIRICREGFPNRLLYADFKQRYCILNPRTFPKSKFVSS 634
                          650       660
                   ....*....|....*....|....*...
gi 2462555497  740 KKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14929    635 RKAAEELLGSLEIDHTQYRFGITKVFFK 662
Myosin_head pfam00063
Myosin head (motor domain);
88-767 0e+00

Myosin head (motor domain);


Pssm-ID: 395017 [Multi-domain]  Cd Length: 674  Bit Score: 1030.30  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   88 IEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFML 167
Cdd:pfam00063    1 VEDMVELSYLNEPSVLHNLKKRYKSDLIYTYSGLVLVAVNPYKQLPIYSEDMIKAYRGKRRGELPPHIFAIADEAYRSML 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  168 TDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKkkdskmKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGK 247
Cdd:pfam00063   81 QDKENQSILISGESGAGKTENTKKIMQYLASVSGSGSAGN------VGRLEEQILQSNPILEAFGNAKTVRNNNSSRFGK 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  248 FIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLItTNPYDYPFISQ-GEILVASIDD 326
Cdd:pfam00063  155 YIEIQFDAKGDIVGGKIETYLLEKSRVVYQAEGERNYHIFYQLLAGASAQLKKELRL-TNPKDYHYLSQsGCYTIDGIDD 233
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  327 AEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVK 406
Cdd:pfam00063  234 SEEFKITDKAMDILGFSDEEQMGIFRIVAAILHLGNIEFKKERNDEQAVPDDTENLQKAASLLGIDSTELEKALCKRRIK 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  407 VGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLD-TKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEK 485
Cdd:pfam00063  314 TGRETVSKPQNVEQANYARDALAKAIYSRLFDWLVDRINKSLDvKTIEKASFIGVLDIYGFEIFEKNSFEQLCINYVNEK 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  486 LQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKLYDQHlGKSNNF 564
Cdd:pfam00063  394 LQQFFNHHMFKLEQEEYVREGIEWTFIDFG-DNQPCIDLIEkKPLGILSLLDEECLFPKATDQTFLDKLYSTF-SKHPHF 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  565 QKPKVvkgRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATAD----ADSGKKKVAKK 640
Cdd:pfam00063  472 QKPRL---QGETHFIIKHYAGDVEYNVEGFLEKNKDPLNDDLVSLLKSSSDPLLAELFPDYETAEsaaaNESGKSTPKRT 548
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  641 KGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFK 720
Cdd:pfam00063  549 KKKRFITVGSQFKESLGELMKTLNSTNPHYIRCIKPNEKKRAGVFDNSLVLHQLRCNGVLEGIRIRRAGFPNRITFQEFV 628
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 2462555497  721 QRYRVLNASAIPEGqFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:pfam00063  629 QRYRILAPKTWPKW-KGDAKKGCEAILQSLNLDKEEYQFGKTKIFFR 674
MYSc_Myh16 cd14934
class II myosin heavy chain 16, motor domain; Myosin motor domain of myosin heavy chain 16 ...
101-767 0e+00

class II myosin heavy chain 16, motor domain; Myosin motor domain of myosin heavy chain 16 pseudogene (also called MHC20, MYH16, and myh5), encoding a sarcomeric myosin heavy chain expressed in nonhuman primate masticatory muscles, is inactivated in humans. This cd contains Myh16 in mammals. MYH16 has intermediate fibres between that of slow type 1 and fast 2B fibres, but exert more force than any other fibre type examined. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Some of the data used for this classification were produced by the CyMoBase team at the Max-Planck-Institute for Biophysical Chemistry. The sequence names are composed of the species abbreviation followed by the protein abbreviation and optional protein classifier and variant designations.


Pssm-ID: 276896 [Multi-domain]  Cd Length: 659  Bit Score: 994.92  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 180
Cdd:cd14934      2 SVLDNLRQRYTNMRIYTYSGLFCVTVNPYKWLPIYGARVANMYKGKKRTEMPPHLFSISDNAYHDMLMDRENQSMLITGE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  181 SGAGKTVNTKRVIQYFATIAATGdlakKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLA 260
Cdd:cd14934     82 SGAGKTENTKKVIQYFANIGGTG----KQSSDGKGSLEDQIIQANPVLEAFGNAKTTRNNNSSRFGKFIRIHFGTTGKLA 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  261 SADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDIL 340
Cdd:cd14934    158 GADIESYLLEKSRVISQQAAERGYHIFYQILSNKKPELIESLLLVPNPKEYHWVSQGVTVVDNMDDGEELQITDVAFDVL 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  341 GFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQ 420
Cdd:cd14934    238 GFSAEEKIGVYKLTGGIMHFGNMKFKQKPREEQAEVDTTEVADKVAHLMGLNSGELQKGITRPRVKVGNEFVQKGQNMEQ 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  421 VHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQE 500
Cdd:cd14934    318 CNNSIGALGKAVYDKMFKWLVVRINKTLDTKMQRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNHHMFVLEQE 397
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  501 EYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGR-AEAHFS 579
Cdd:cd14934    398 EYKREGIEWVFIDFGLDLQACIDLLEKPMGIFSILEEQCVFPKATDATFKAALYDNHLGKSSNFLKPKGGKGKgPEAHFE 477
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  580 LIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADAdsgkkKVAKKKGSSFQTVSALFRENLNKL 659
Cdd:cd14934    478 LVHYAGTVGYNITGWLEKNKDPLNETVVGLFQKSSLGLLALLFKEEEAPAG-----SKKQKRGSSFMTVSNFYREQLNKL 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  660 MSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGqFIDS 739
Cdd:cd14934    553 MTTLHSTAPHFVRCIVPNEFKQSGVVDAHLIMHQLACNGVLEGIRICRKGFPNRLQYPEFKQRYQVLNPNVIPQG-FVDN 631
                          650       660
                   ....*....|....*....|....*...
gi 2462555497  740 KKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14934    632 KKASELLLGSIDLDVNEYKIGHTKVFFR 659
MYSc smart00242
Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical ...
81-779 0e+00

Myosin. Large ATPases; ATPase; molecular motor. Muscle contraction consists of a cyclical interaction between myosin and actin. The core of the myosin structure is similar in fold to that of kinesin.


Pssm-ID: 214580 [Multi-domain]  Cd Length: 677  Bit Score: 989.74  E-value: 0e+00
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497    81 NPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISD 160
Cdd:smart00242    1 NPPKFEGVEDLVLLTYLNEPAVLHNLKKRYLKDLIYTYIGLVLVAVNPYKQLPIYTDEVIKKYRGKSRGELPPHVFAIAD 80
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   161 NAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATgdlakkkdSKMKGTLEDQIISANPLLEAFGNAKTVRND 240
Cdd:smart00242   81 NAYRNMLNDKENQSIIISGESGAGKTENTKKIMQYLASVSGS--------NTEVGSVEDQILESNPILEAFGNAKTLRNN 152
                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   241 NSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTnPYDYPFISQG-EI 319
Cdd:smart00242  153 NSSRFGKFIEIHFDAKGKIIGAKIETYLLEKSRVVSQAKGERNYHIFYQLLAGASEELKKELGLKS-PEDYRYLNQGgCL 231
                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   320 LVASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQA-EPDGTEVADKTAYLMGLNSSDLLK 398
Cdd:smart00242  232 TVDGIDDAEEFKETLNAMRVLGFSEEEQESIFKILAAILHLGNIEFEEGRNDNAAsTVKDKEELSNAAELLGVDPEELEK 311
                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   399 ALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLC 478
Cdd:smart00242  312 ALTKRKIKTGGEVITKPLNVEQALDARDALAKALYSRLFDWLVKRINQSLSFKDGSTYFIGVLDIYGFEIFEVNSFEQLC 391
                           410       420       430       440       450       460       470       480
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   479 INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKLYdQH 557
Cdd:smart00242  392 INYANEKLQQFFNQHVFKLEQEEYEREGIDWTFIDFF-DNQDCIDLIEkKPPGILSLLDEECRFPKGTDQTFLEKLN-QH 469
                           490       500       510       520       530       540       550       560
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   558 LGKSNNFQKPKVvkgRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYatfatadadsGKKKV 637
Cdd:smart00242  470 HKKHPHFSKPKK---KGRTEFIIKHYAGDVTYDVTGFLEKNKDTLSDDLIELLQSSKNPLIASLF----------PSGVS 536
                           570       580       590       600       610       620       630       640
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   638 AKKKGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYG 717
Cdd:smart00242  537 NAGSKKRFQTVGSQFKEQLNELMDTLNSTNPHFIRCIKPNEEKKPGDFDSSLVLHQLRYLGVLENIRIRRAGFPYRLPFD 616
                           650       660       670       680       690       700
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462555497   718 DFKQRYRVLNASAIPEGQFiDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRD 779
Cdd:smart00242  617 EFLQRYRVLLPDTWPPWGG-DAKKACEALLQSLGLDEDEYQLGKTKVFLRPGQLAELEELRE 677
MYSc_Myh1_insects_crustaceans cd14909
class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle ...
100-767 0e+00

class II myosin heavy chain 1, motor domain; Myosin motor domain of type IIx skeletal muscle myosin heavy chain 1 (also called MYHSA1, MYHa, MyHC-2X/D, MGC133384) in insects and crustaceans. Myh1 is a type I skeletal muscle myosin that in Humans is encoded by the MYH1 gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276874  Cd Length: 666  Bit Score: 970.46  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14909      1 ASVLHNLRQRYYAKLIYTYSGLFCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGdlAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 259
Cdd:cd14909     81 ESGAGKTENTKKVIAYFATVGASK--KTDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKL 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  260 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDI 339
Cdd:cd14909    159 AGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKEMCLLSDNIYDYYIVSQGKVTVPNVDDGEEFSLTDQAFDI 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  340 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVD 419
Cdd:cd14909    239 LGFTKQEKEDVYRITAAVMHMGGMKFKQRGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQ 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  420 QVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQ 499
Cdd:cd14909    319 QVTNSIGALCKGVFDRLFKWLVKKCNETLDTQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFVLEQ 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  500 EEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVK-GRAEAHF 578
Cdd:cd14909    399 EEYKREGIDWAFIDFGMDLLACIDLIEKPMGILSILEEESMFPKATDQTFSEKLTNTHLGKSAPFQKPKPPKpGQQAAHF 478
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  579 SLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKV-AKKKGSSFQTVSALFRENLN 657
Cdd:cd14909    479 AIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIFADHAGQSGGGEQAKGgRGKKGGGFATVSSAYKEQLN 558
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  658 KLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQfi 737
Cdd:cd14909    559 SLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMRYKILNPAGIQGEE-- 636
                          650       660       670
                   ....*....|....*....|....*....|
gi 2462555497  738 DSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14909    637 DPKKAAEIILESIALDPDQYRLGHTKVFFR 666
MYSc cd00124
Myosin motor domain superfamily; Myosin motor domain. The catalytic (head) domain has ATPase ...
100-767 0e+00

Myosin motor domain superfamily; Myosin motor domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276950 [Multi-domain]  Cd Length: 633  Bit Score: 837.24  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQ-EAPPHIFSISDNAYQFMLTDRENQSILIT 178
Cdd:cd00124      1 AAILHNLRERYARDLIYTYVGDILVAVNPFKWLPLYSEEVMEKYRGKGRSaDLPPHVFAVADAAYRAMLRDGQNQSILIS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  179 GESGAGKTVNTKRVIQYFATIAATGdlaKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 258
Cdd:cd00124     81 GESGAGKTETTKLVLKYLAALSGSG---SSKSSSSASSIEQQILQSNPILEAFGNAKTVRNDNSSRFGKFIELQFDPTGR 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  259 LASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIE---LLLITTNPYDYPFISQGEIL-VASIDDAEELLATD 334
Cdd:cd00124    158 LVGASIETYLLEKSRVVSQAPGERNFHIFYQLLAGLSDGAREelkLELLLSYYYLNDYLNSSGCDrIDGVDDAEEFQELL 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  335 SAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREE--QAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYV 412
Cdd:cd00124    238 DALDVLGFSDEEQDSIFRILAAILHLGNIEFEEDEEDEdsSAEVADDESLKAAAKLLGVDAEDLEEALTTRTIKVGGETI 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  413 TKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQ--HFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFF 490
Cdd:cd00124    318 TKPLTVEQAEDARDALAKALYSRLFDWLVNRINAALSPTDAAEstSFIGILDIFGFENFEVNSFEQLCINYANEKLQQFF 397
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  491 NHHMFVLEQEEYKKEGIEWTFIDFgMDLAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKV 569
Cdd:cd00124    398 NQHVFKLEQEEYEEEGIDWSFIDF-PDNQDCLDLIEgKPLGILSLLDEECLFPKGTDATFLEKLYSAHGSHPRFFSKKRK 476
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  570 VKGraeaHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSnrllahlyatfatadadsgkkkvakkkgssfqtvs 649
Cdd:cd00124    477 AKL----EFGIKHYAGDVTYDADGFLEKNKDTLPPDLVDLLRSGS----------------------------------- 517
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  650 aLFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNAS 729
Cdd:cd00124    518 -QFRSQLDALMDTLNSTQPHFVRCIKPNDEKKPGLFDPELVLEQLRCAGVLEAVRIRRAGYPVRLPFDEFLKRYRILAPG 596
                          650       660       670
                   ....*....|....*....|....*....|....*...
gi 2462555497  730 AiPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd00124    597 A-TEKASDSKKAAVLALLLLLKLDSSGYQLGKTKVFLR 633
COG5022 COG5022
Myosin heavy chain [General function prediction only];
31-1112 0e+00

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 832.03  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   31 PFDAKTYCFVVDSKEEYAKGKIKSsqdgkvTVETEDNRTLVVKPEDV--YAMNPPKFDRIEDMAMLTHLNEPAVLYNLKD 108
Cdd:COG5022     15 PDEEKGWIWAEIIKEAFNKGKVTE------EGKKEDGESVSVKKKVLgnDRIKLPKFDGVDDLTELSYLNEPAVLHNLEK 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  109 RYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVN 188
Cdd:COG5022     89 RYNNGQIYTYSGLVLIAVNPYRDLGIYTDDIIQSYSGKNRLELEPHVFAIAEEAYRNLLSEKENQTIIISGESGAGKTEN 168
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  189 TKRVIQYFATIAATgdlakkkDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYL 268
Cdd:COG5022    169 AKRIMQYLASVTSS-------STVEISSIEKQILATNPILEAFGNAKTVRNDNSSRFGKYIKIEFDENGEICGAKIETYL 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  269 LEKSRVTFQLKAERSYHIFYQILSNKkPELIELLLITTNPYDYPFISQGE-ILVASIDDAEELLATDSAIDILGFTPEEK 347
Cdd:COG5022    242 LEKSRVVHQNKNERNYHIFYQLLAGD-PEELKKLLLLQNPKDYIYLSQGGcDKIDGIDDAKEFKITLDALKTIGIDEEEQ 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  348 SGLYKLTGAVMHYGNMKFKqKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNA 427
Cdd:COG5022    321 DQIFKILAAILHIGNIEFK-EDRNGAAIFSDNSVLDKACYLLGIDPSLFVKWLVKRQIKTGGEWIVVPLNLEQALAIRDS 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  428 LSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGI 507
Cdd:COG5022    400 LAKALYSNLFDWIVDRINKSLDHSAAASNFIGVLDIYGFEIFEKNSFEQLCINYTNEKLQQFFNQHMFKLEQEEYVKEGI 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  508 EWTFIDFgMDLAACIELIEK--PMGIFSILEEECMFPKATDTSFKNKLYDQ-HLGKSNNFQKPKVvkgrAEAHFSLIHYA 584
Cdd:COG5022    480 EWSFIDY-FDNQPCIDLIEKknPLGILSLLDEECVMPHATDESFTSKLAQRlNKNSNPKFKKSRF----RDNKFVVKHYA 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  585 GTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYatfatadadsgKKKVAKKKGSSFQTVSALFRENLNKLMSNLR 664
Cdd:COG5022    555 GDVEYDVEGFLDKNKDPLNDDLLELLKASTNEFVSTLF-----------DDEENIESKGRFPTLGSRFKESLNSLMSTLN 623
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  665 TTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQFI---DSKK 741
Cdd:COG5022    624 STQPHYIRCIKPNEEKSPWTFDNQMVLSQLRCCGVLETIRISRAGFPSRWTFDEFVQRYRILSPSKSWTGEYTwkeDTKN 703
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  742 ACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLITRTQAVCRGFLMRVEFQKMVQRRESIFCIQYNIRS 821
Cdd:COG5022    704 AVKSILEELVIDSSKYQIGNTKVFFKAGVLAALEDMRDAKLDNIATRIQRAIRGRYLRRRYLQALKRIKKIQVIQHGFRL 783
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  822 FMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELaKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 901
Cdd:COG5022    784 RRLVDYELKWRLFIKLQPLLSLLGSRKEYRSYLACIIKLQKTI-KREKKLRETEEVEFSLKAEVLIQKFGRSLKAKKRFS 862
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  902 AEERCDQLIKAKFQLEAKIKEVTERAEDEEEINaELTAKKRKLEDECSELKKDIDDLELtlakvekekhateNKVKNLTE 981
Cdd:COG5022    863 LLKKETIYLQSAQRVELAERQLQELKIDVKSIS-SLKLVNLELESEIIELKKSLSSDLI-------------ENLEFKTE 928
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  982 ELSGLDETIAKLTREKKALQEAHQQalddlqaeeDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLK 1061
Cdd:COG5022    929 LIARLKKLLNNIDLEEGPSIEYVKL---------PELNKLHEVESKLKETSEEYEDLLKKSTILVREGNKANSELKNFKK 999
                         1050      1060      1070      1080      1090
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462555497 1062 LAQEsILDLENDKQQLDERLKKKDFEYCQLQS--KVEDEQTLGLQFQKKIKEL 1112
Cdd:COG5022   1000 ELAE-LSKQYGALQESTKQLKELPVEVAELQSasKIISSESTELSILKPLQKL 1051
MYSc_Myh2_insects_mollusks cd14911
class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle ...
101-767 0e+00

class II myosin heavy chain 2, motor domain; Myosin motor domain of type IIa skeletal muscle myosin heavy chain 2 (also called MYH2A, MYHSA2, MyHC-IIa, MYHas8, MyHC-2A) in insects and mollusks. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. Mutations in this gene results in inclusion body myopathy-3 and familial congenital myopathy. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276876 [Multi-domain]  Cd Length: 674  Bit Score: 813.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 180
Cdd:cd14911      2 SVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  181 SGAGKTVNTKRVIQYFATIAAT---GDLAKKKDSK----MKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF 253
Cdd:cd14911     82 SGAGKTENTKKVIQFLAYVAASkpkGSGAVPHPAVnpavLIGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  254 GTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITtNPYDYPFISQGEILVASIDDAEELLAT 333
Cdd:cd14911    162 DASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILD-DVKSYAFLSNGSLPVPGVDDYAEFQAT 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  334 DSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAE-PDGTeVADKTAYLMGLNSSDLLKALCFPRVKVGNEYV 412
Cdd:cd14911    241 VKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATlPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFV 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  413 TKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLD-TKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFN 491
Cdd:cd14911    320 TKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDrTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFN 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  492 HHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLgksnnfQKPKVVK 571
Cdd:cd14911    400 HTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAHS------MHPKFMK 473
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  572 G--RAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLY--------ATFATADADSGKKKVAkkk 641
Cdd:cd14911    474 TdfRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWkdaeivgmAQQALTDTQFGARTRK--- 550
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  642 gSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQ 721
Cdd:cd14911    551 -GMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQ 629
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*.
gi 2462555497  722 RYRVLNASAIPEGqFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14911    630 RYELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQSKIFFR 674
MYSc_Myh10 cd14920
class II myosin heavy chain 10, motor domain; Myosin motor domain of non-muscle myosin heavy ...
101-767 0e+00

class II myosin heavy chain 10, motor domain; Myosin motor domain of non-muscle myosin heavy chain 10 (also called NMMHCB). Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276952 [Multi-domain]  Cd Length: 673  Bit Score: 784.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 180
Cdd:cd14920      2 SVLHNLKDRYYSGLIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  181 SGAGKTVNTKRVIQYFATIAATGDlaKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLA 260
Cdd:cd14920     82 SGAGKTENTKKVIQYLAHVASSHK--GRKDHNIPGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIV 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  261 SADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPEL-IELLLITTNpyDYPFISQGEILVASIDDAEELLATDSAIDI 339
Cdd:cd14920    160 GANIETYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLkSDLLLEGFN--NYRFLSNGYIPIPGQQDKDNFQETMEAMHI 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  340 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAE-PDGTeVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTV 418
Cdd:cd14920    238 MGFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASmPENT-VAQKLCHLLGMNVMEFTRAILTPRIKVGRDYVQKAQTK 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  419 DQVHHAVNALSKSVYEKLFLWMVTRINQQLD-TKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVL 497
Cdd:cd14920    317 EQADFAVEALAKATYERLFRWLVHRINKALDrTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFIL 396
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  498 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPM---GIFSILEEECMFPKATDTSFKNKLyDQHLGKSNNFQKPKVVKGra 574
Cdd:cd14920    397 EQEEYQREGIEWNFIDFGLDLQPCIDLIERPAnppGVLALLDEECWFPKATDKTFVEKL-VQEQGSHSKFQKPRQLKD-- 473
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  575 EAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSS--------FQ 646
Cdd:cd14920    474 KADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDVDRIVGLDQVTGMTETAFGSayktkkgmFR 553
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  647 TVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVL 726
Cdd:cd14920    554 TVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEIL 633
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|.
gi 2462555497  727 NASAIPEGqFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14920    634 TPNAIPKG-FMDGKQACERMIRALELDPNLYRIGQSKIFFR 673
MYSc_Myh18 cd14932
class II myosin heavy chain 18, motor domain; Myosin motor domain of muscle myosin heavy chain ...
101-767 0e+00

class II myosin heavy chain 18, motor domain; Myosin motor domain of muscle myosin heavy chain 18. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276895 [Multi-domain]  Cd Length: 676  Bit Score: 722.58  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 180
Cdd:cd14932      2 SVLHNLKERYYSGLIYTYSGLFCVVINPYKYLPIYSEEIVNMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  181 SGAGKTVNTKRVIQYFATIAATGDLAKKKDSKM--KGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 258
Cdd:cd14932     82 SGAGKTENTKKVIQYLAYVASSFKTKKDQSSIAlsHGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGY 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  259 LASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPEL-IELLLITTNPYDypFISQGEILVASIDDAEELLATDSAI 337
Cdd:cd14932    162 IVGANIETYLLEKSRAIRQAKDERAFHIFYYLLTGAGDKLrSELCLEDYSKYR--FLSNGNVTIPGQQDKELFAETMEAF 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  338 DILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAE-PDGTeVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQ 416
Cdd:cd14932    240 RIMSIPEEEQTGLLKVVSAVLQLGNMSFKKERNSDQASmPDDT-AAQKVCHLLGMNVTDFTRAILSPRIKVGRDYVQKAQ 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  417 TVDQVHHAVNALSKSVYEKLFLWMVTRINQQLD-TKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMF 495
Cdd:cd14932    319 TQEQAEFAVEALAKASYERMFRWLVMRINKALDkTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMF 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  496 VLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPM---GIFSILEEECMFPKATDTSFKNKLYdQHLGKSNNFQKPKVVKG 572
Cdd:cd14932    399 ILEQEEYQREGIEWSFIDFGLDLQPCIELIEKPNgppGILALLDEECWFPKATDKSFVEKVV-QEQGNNPKFQKPKKLKD 477
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  573 raEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATF----------ATADADSGKKKVAKkkg 642
Cdd:cd14932    478 --DADFCIIHYAGKVDYKANEWLMKNMDPLNENVATLLNQSTDKFVSELWKDVdrivgldkvaGMGESLHGAFKTRK--- 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  643 SSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQR 722
Cdd:cd14932    553 GMFRTVGQLYKEQLMNLMTTLRNTNPNFVRCIIPNHEKKAGKLAHHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQR 632
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*
gi 2462555497  723 YRVLNASAIPEGqFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14932    633 YEILTPNAIPKG-FMDGKQACVLMVKALELDPNLYRIGQSKVFFR 676
MYSc_Myh11 cd14921
class II myosin heavy chain 11, motor domain; Myosin motor domain of smooth muscle myosin ...
101-767 0e+00

class II myosin heavy chain 11, motor domain; Myosin motor domain of smooth muscle myosin heavy chain 11 (also called SMMHC, SMHC). The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. Inversion of the MYH11 locus is one of the most frequent chromosomal aberrations found in acute myeloid leukemia. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Mutations in MYH11 have been described in individuals with thoracic aortic aneurysms leading to acute aortic dissections with patent ductus arteriosus. MYH11 mutations are also thought to contribute to human colorectal cancer and are also associated with Peutz-Jeghers syndrome. The mutations found in human intestinal neoplasia result in unregulated proteins with constitutive motor activity, similar to the mutant myh11 zebrafish. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276885 [Multi-domain]  Cd Length: 673  Bit Score: 705.24  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 180
Cdd:cd14921      2 SVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  181 SGAGKTVNTKRVIQYFATIAATGDlaKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLA 260
Cdd:cd14921     82 SGAGKTENTKKVIQYLAVVASSHK--GKKDTSITGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIV 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  261 SADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPyDYPFISQGEILVASIDDAEELLATDSAIDIL 340
Cdd:cd14921    160 GANIETYLLEKSRAIRQARDERTFHIFYYLIAGAKEKMRSDLLLEGFN-NYTFLSNGFVPIPAAQDDEMFQETLEAMSIM 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  341 GFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAE-PDGTeVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVD 419
Cdd:cd14921    239 GFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASmPDNT-AAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKE 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  420 QVHHAVNALSKSVYEKLFLWMVTRINQQLD-TKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLE 498
Cdd:cd14921    318 QADFAIEALAKATYERLFRWILTRVNKALDkTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILE 397
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  499 QEEYKKEGIEWTFIDFGMDLAACIELIEKPM---GIFSILEEECMFPKATDTSFKNKLYdQHLGKSNNFQKPKVVKGRAE 575
Cdd:cd14921    398 QEEYQREGIEWNFIDFGLDLQPCIELIERPNnppGVLALLDEECWFPKATDKSFVEKLC-TEQGNHPKFQKPKQLKDKTE 476
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  576 ahFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATF--------ATADADSGKKKVAKKKGSSFQT 647
Cdd:cd14921    477 --FSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVdrivgldqMAKMTESSLPSASKTKKGMFRT 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  648 VSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLN 727
Cdd:cd14921    555 VGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILA 634
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|
gi 2462555497  728 ASAIPEGqFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14921    635 ANAIPKG-FMDGKQACILMIKALELDPNLYRIGQSKIFFR 673
MYSc_Myo5 cd01380
class V myosin, motor domain; Myo5, also called heavy chain 12, myoxin, are dimeric myosins ...
100-767 0e+00

class V myosin, motor domain; Myo5, also called heavy chain 12, myoxin, are dimeric myosins that transport a variety of intracellular cargo processively along actin filaments, such as melanosomes, synaptic vesicles, vacuoles, and mRNA. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. It also contains a IQ domain and a globular DIL domain. Myosin V is a class of actin-based motor proteins involved in cytoplasmic vesicle transport and anchorage, spindle-pole alignment and mRNA translocation. The protein encoded by this gene is abundant in melanocytes and nerve cells. Mutations in this gene cause Griscelli syndrome type-1 (GS1), Griscelli syndrome type-3 (GS3) and neuroectodermal melanolysosomal disease, or Elejalde disease. Multiple alternatively spliced transcript variants encoding different isoforms have been reported, but the full-length nature of some variants has not been determined. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Note that the Dictyostelium myoVs are not contained in this child group. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276831 [Multi-domain]  Cd Length: 629  Bit Score: 692.36  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYT-SWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILIT 178
Cdd:cd01380      1 PAVLHNLKVRFCqRNAIYTYCGIVLVAINPYEDLPIYGEDIIQAYSGQNMGELDPHIFAIAEEAYRQMARDEKNQSIIVS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  179 GESGAGKTVNTKRVIQYFATIAATgdlakkkDSKMKGTlEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 258
Cdd:cd01380     81 GESGAGKTVSAKYAMRYFATVGGS-------SSGETQV-EEKVLASNPIMEAFGNAKTTRNDNSSRFGKYIEILFDKNYR 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  259 LASADIETYLLEKSRVTFQLKAERSYHIFYQILSNK-KPELIELLLitTNPYDYPFISQGE-ILVASIDDAEELLATDSA 336
Cdd:cd01380    153 IIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCAAAsLPELKELHL--GSAEDFFYTNQGGsPVIDGVDDAAEFEETRKA 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  337 IDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQ 416
Cdd:cd01380    231 LTLLGISEEEQMEIFRILAAILHLGNVEIKATRNDSASISPDDEHLQIACELLGIDESQLAKWLCKRKIVTRSEVIVKPL 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  417 TVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLP--RQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHM 494
Cdd:cd01380    311 TLQQAIVARDALAKHIYAQLFDWIVDRINKALASPVKekQHSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNQHV 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  495 FVLEQEEYKKEGIEWTFIDFgMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNN-FQKPKVVKGR 573
Cdd:cd01380    391 FKLEQEEYVKEEIEWSFIDF-YDNQPCIDLIEGKLGILDLLDEECRLPKGSDENWAQKLYNQHLKKPNKhFKKPRFSNTA 469
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  574 aeahFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLlahlyatfatadadsgkkkvakkkgssfQTVSALFR 653
Cdd:cd01380    470 ----FIVKHFADDVEYQVEGFLEKNRDTVSEEHLNVLKASKNRK----------------------------KTVGSQFR 517
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  654 ENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAipE 733
Cdd:cd01380    518 DSLILLMETLNSTTPHYVRCIKPNDEKLPFTFDPKRVVQQLRACGVLETIRISAAGFPSRWTYEEFFSRYRVLLPSK--E 595
                          650       660       670
                   ....*....|....*....|....*....|....
gi 2462555497  734 GQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd01380    596 WLRDDKKKTCENILENLILDPDKYQFGKTKIFFR 629
MYSc_Myh9 cd14919
class II myosin heavy chain 9, motor domain; Myosin motor domain of non-muscle myosin heavy ...
101-767 0e+00

class II myosin heavy chain 9, motor domain; Myosin motor domain of non-muscle myosin heavy chain 9 (also called NMMHCA, NMHC-II-A, MHA, FTNS, EPSTS, and DFNA17). Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276883 [Multi-domain]  Cd Length: 670  Bit Score: 678.35  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 180
Cdd:cd14919      2 SVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  181 SGAGKTVNTKRVIQYFATIAATgdlakKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLA 260
Cdd:cd14919     82 SGAGKTENTKKVIQYLAHVASS-----HKSKKDQGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIV 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  261 SADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLIttNPYD-YPFISQGEILVASIDDAEELLATDSAIDI 339
Cdd:cd14919    157 GANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLL--EPYNkYRFLSNGHVTIPGQQDKDMFQETMEAMRI 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  340 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAE-PDGTeVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTV 418
Cdd:cd14919    235 MGIPEEEQMGLLRVISGVLQLGNIVFKKERNTDQASmPDNT-AAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTK 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  419 DQVHHAVNALSKSVYEKLFLWMVTRINQQLD-TKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVL 497
Cdd:cd14919    314 EQADFAIEALAKATYERMFRWLVLRINKALDkTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFIL 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  498 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPM---GIFSILEEECMFPKATDTSFKNKLYdQHLGKSNNFQKPKVVKGRA 574
Cdd:cd14919    394 EQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAgppGILALLDEECWFPKATDKSFVEKVV-QEQGTHPKFQKPKQLKDKA 472
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  575 EahFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATF--------ATADADSGKKKVAKKKGSSFQ 646
Cdd:cd14919    473 D--FCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVdriigldqVAGMSETALPGAFKTRKGMFR 550
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  647 TVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVL 726
Cdd:cd14919    551 TVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEIL 630
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|.
gi 2462555497  727 NASAIPEGqFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14919    631 TPNSIPKG-FMDGKQACVLMIKALELDSNLYRIGQSKVFFR 670
MYSc_Myh14_mammals cd14930
class II myosin heavy chain 14 motor domain; Myosin motor domain of non-muscle myosin heavy ...
101-767 0e+00

class II myosin heavy chain 14 motor domain; Myosin motor domain of non-muscle myosin heavy chain 14 (also called FLJ13881, KIAA2034, MHC16, MYH17). Its members include mammals, chickens, and turtles. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. Some of the data used for this classification were produced by the CyMoBase team at the Max-Planck-Institute for Biophysical Chemistry. The sequence names are composed of the species abbreviation followed by the protein abbreviation and optional protein classifier and variant designations.


Pssm-ID: 276893 [Multi-domain]  Cd Length: 670  Bit Score: 677.97  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 180
Cdd:cd14930      2 SVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHVYAVTEGAYRSMLQDREDQSILCTGE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  181 SGAGKTVNTKRVIQYFATIAATGDlaKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLA 260
Cdd:cd14930     82 SGAGKTENTKKVIQYLAHVASSPK--GRKEPGVPGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVAGYIV 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  261 SADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYdYPFISQGEilVASIDDAEELLA-TDSAIDI 339
Cdd:cd14930    160 GANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPCSH-YRFLTNGP--SSSPGQERELFQeTLESLRV 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  340 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAE-PDGTeVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTV 418
Cdd:cd14930    237 LGFSHEEITSMLRMVSAVLQFGNIVLKRERNTDQATmPDNT-AAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKAQTK 315
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  419 DQVHHAVNALSKSVYEKLFLWMVTRINQQLDtKLPRQ--HFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFV 496
Cdd:cd14930    316 EQADFALEALAKATYERLFRWLVLRLNRALD-RSPRQgaSFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFV 394
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  497 LEQEEYKKEGIEWTFIDFGMDLAACIELIEKPM---GIFSILEEECMFPKATDTSFKNKLyDQHLGKSNNFQKPKVVkgR 573
Cdd:cd14930    395 LEQEEYQREGIPWTFLDFGLDLQPCIDLIERPAnppGLLALLDEECWFPKATDKSFVEKV-AQEQGGHPKFQRPRHL--R 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  574 AEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATF----------ATADADSGKKKVAkkkgS 643
Cdd:cd14930    472 DQADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDVegivgleqvsSLGDGPPGGRPRR----G 547
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  644 SFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRY 723
Cdd:cd14930    548 MFRTVGQLYKESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQEFRQRY 627
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....
gi 2462555497  724 RVLNASAIPEGqFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14930    628 EILTPNAIPKG-FMDGKQACEKMIQALELDPNLYRVGQSKIFFR 670
MYSc_Myh19 cd15896
class II myosin heavy chain19, motor domain; Myosin motor domain of muscle myosin heavy chain ...
101-767 0e+00

class II myosin heavy chain19, motor domain; Myosin motor domain of muscle myosin heavy chain 19. Class II myosins, also called conventional myosins, are the myosin type responsible for producing actomyosin contraction in metazoan muscle and non-muscle cells. Myosin II contains two heavy chains made up of the head (N-terminal) and tail (C-terminal) domains with a coiled-coil morphology that holds the two heavy chains together. The intermediate neck domain is the region creating the angle between the head and tail. It also contains 4 light chains which bind the heavy chains in the "neck" region between the head and tail. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. Class-II myosins are regulated by phosphorylation of the myosin light chain or by binding of Ca2+. A cyclical interaction between myosin and actin provides the driving force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276899 [Multi-domain]  Cd Length: 675  Bit Score: 677.94  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 180
Cdd:cd15896      2 SVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  181 SGAGKTVNTKRVIQYFATIAATGDLAKKKDSKM--KGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 258
Cdd:cd15896     82 SGAGKTENTKKVIQYLAHVASSHKTKKDQNSLAlsHGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGY 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  259 LASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLItTNPYDYPFISQGEILVASIDDAEELLATDSAID 338
Cdd:cd15896    162 IVGANIETYLLEKSRAIRQAKEERTFHIFYYLLTGAGDKLRSELLL-ENYNNYRFLSNGNVTIPGQQDKDLFTETMEAFR 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  339 ILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTV 418
Cdd:cd15896    241 IMGIPEDEQIGMLKVVASVLQLGNMSFKKERHTDQASMPDNTAAQKVCHLMGMNVTDFTRAILSPRIKVGRDYVQKAQTQ 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  419 DQVHHAVNALSKSVYEKLFLWMVTRINQQLD-TKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVL 497
Cdd:cd15896    321 EQAEFAVEALAKATYERMFRWLVMRINKALDkTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFIL 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  498 EQEEYKKEGIEWTFIDFGMDLAACIELIEKPM---GIFSILEEECMFPKATDTSFKNKLYdQHLGKSNNFQKPKVVKGra 574
Cdd:cd15896    401 EQEEYQREGIEWSFIDFGLDLQPCIDLIEKPAsppGILALLDEECWFPKATDKSFVEKVL-QEQGTHPKFFKPKKLKD-- 477
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  575 EAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYA---TFATADADSGKKKVA---KKKGSSFQTV 648
Cdd:cd15896    478 EADFCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLNQSTDKFVSELWKdvdRIVGLDKVSGMSEMPgafKTRKGMFRTV 557
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  649 SALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNA 728
Cdd:cd15896    558 GQLYKEQLSKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTP 637
                          650       660       670
                   ....*....|....*....|....*....|....*....
gi 2462555497  729 SAIPEGqFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd15896    638 NAIPKG-FMDGKQACVLMIKSLELDPNLYRIGQSKVFFR 675
MYSc_Myo8 cd01383
class VIII myosin, motor domain; These plant-specific type VIII myosins has been associated ...
100-767 0e+00

class VIII myosin, motor domain; These plant-specific type VIII myosins has been associated with endocytosis, cytokinesis, cell-to-cell coupling and gating at plasmodesmata. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. It also contains IQ domains Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276834  Cd Length: 647  Bit Score: 645.53  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRgkKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd01383      1 PSVLHNLEYRYSQDIIYTKAGPVLIAVNPFKDVPLYGNEFITAYR--QKLLDSPHVYAVADTAYREMMRDEINQSIIISG 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGDlakkkdskmkgTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 259
Cdd:cd01383     79 ESGAGKTETAKIAMQYLAALGGGSS-----------GIENEILQTNPILEAFGNAKTLRNDNSSRFGKLIDIHFDAAGKI 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  260 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTnPYDYPFISQGEIL-VASIDDAEELLATDSAID 338
Cdd:cd01383    148 CGAKIQTYLLEKSRVVQLANGERSYHIFYQLCAGASPALREKLNLKS-ASEYKYLNQSNCLtIDGVDDAKKFHELKEALD 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  339 ILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTV 418
Cdd:cd01383    227 TVGISKEDQEHIFQMLAAVLWLGNISFQVIDNENHVEVVADEAVSTAASLLGCNANDLMLALSTRKIQAGGDKIVKKLTL 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  419 DQVHHAVNALSKSVYEKLFLWMVTRINQQLDT-KLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVL 497
Cdd:cd01383    307 QQAIDARDALAKAIYASLFDWLVEQINKSLEVgKRRTGRSISILDIYGFESFQKNSFEQLCINYANERLQQHFNRHLFKL 386
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  498 EQEEYKKEGIEWTFIDFgMDLAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKLyDQHLGKSNNFqkpkvvKGRAEA 576
Cdd:cd01383    387 EQEEYELDGIDWTKVDF-EDNQECLDLIEkKPLGLISLLDEESNFPKATDLTFANKL-KQHLKSNSCF------KGERGG 458
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  577 HFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQkSSNRLLAHLYAT-FATADADSGKKKVAKKKGSSFQTVSALFREN 655
Cdd:cd01383    459 AFTIRHYAGEVTYDTSGFLEKNRDLLHSDLIQLLS-SCSCQLPQLFASkMLDASRKALPLTKASGSDSQKQSVATKFKGQ 537
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  656 LNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPEGQ 735
Cdd:cd01383    538 LFKLMQRLENTTPHFIRCIKPNNKQLPGVFDQDLVLQQLRCCGVLEVVRISRSGYPTRMTHQEFARRYGFLLPEDVSASQ 617
                          650       660       670
                   ....*....|....*....|....*....|..
gi 2462555497  736 FIDSkkACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd01383    618 DPLS--TSVAILQQFNILPEMYQVGYTKLFFR 647
MYSc_Myo7 cd01381
class VII myosin, motor domain; These monomeric myosins have been associated with functions in ...
101-767 0e+00

class VII myosin, motor domain; These monomeric myosins have been associated with functions in sensory systems such as vision and hearing. Mammalian myosin VII has a tail with 2 MyTH4 domains, 2 FERM domains, and a SH3 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276832  Cd Length: 648  Bit Score: 630.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 180
Cdd:cd01381      2 GILRNLLIRYREKLIYTYTGSILVAVNPYQILPIYTAEQIRLYRNKKIGELPPHIFAIADNAYTNMKRNKRDQCVVISGE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  181 SGAGKTVNTKRVIQYFATIaatgdlakkkdSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLA 260
Cdd:cd01381     82 SGAGKTESTKLILQYLAAI-----------SGQHSWIEQQILEANPILEAFGNAKTIRNDNSSRFGKYIDIHFNKNGVIE 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  261 SADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTnPYDYPFISQGEILVAS-IDDAEELLATDSAIDI 339
Cdd:cd01381    151 GAKIEQYLLEKSRIVSQAPDERNYHIFYCMLAGLSAEEKKKLELGD-ASDYYYLTQGNCLTCEgRDDAAEFADIRSAMKV 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  340 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKQRE--EQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQT 417
Cdd:cd01381    230 LMFTDEEIWDIFKLLAAILHLGNIKFEATVVDnlDASEVRDPPNLERAAKLLEVPKQDLVDALTTRTIFTRGETVVSPLS 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  418 VDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHF---IGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHM 494
Cdd:cd01381    310 AEQALDVRDAFVKGIYGRLFIWIVNKINSAIYKPRGTDSSrtsIGVLDIFGFENFEVNSFEQLCINFANENLQQFFVRHI 389
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  495 FVLEQEEYKKEGIEWTFIDFgMDLAACIELI-EKPMGIFSILEEECMFPKATDTSFKNKLYDQHlGKSNNFQKPkvvKGR 573
Cdd:cd01381    390 FKLEQEEYDKEGINWQHIEF-VDNQDVLDLIaLKPMNIMSLIDEESKFPKGTDQTMLEKLHSTH-GNNKNYLKP---KSD 464
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  574 AEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKvakkkgssfQTVSALFR 653
Cdd:cd01381    465 LNTSFGINHFAGVVFYDTRGFLEKNRDTFSADLLQLVQSSKNKFLKQLFNEDISMGSETRKKS---------PTLSSQFR 535
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  654 ENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLnASAIPE 733
Cdd:cd01381    536 KSLDQLMKTLSACQPFFVRCIKPNEYKKPMLFDRELCVRQLRYSGMMETIRIRKAGYPIRHTFEEFVERYRVL-VPGIPP 614
                          650       660       670
                   ....*....|....*....|....*....|....
gi 2462555497  734 GQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd01381    615 AHKTDCRAATRKICCAVLGGDADYQLGKTKIFLK 648
MYSc_Myo1 cd01378
class I myosin, motor domain; Myosin I generates movement at the leading edge in cell motility, ...
101-767 0e+00

class I myosin, motor domain; Myosin I generates movement at the leading edge in cell motility, and class I myosins have been implicated in phagocytosis and vesicle transport. Myosin I, an unconventional myosin, does not form dimers. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. There are 5 myosin subclasses with subclasses c/h, d/g, and a/b have an IQ domain and a TH1 domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276829  Cd Length: 652  Bit Score: 623.41  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 180
Cdd:cd01378      2 AINENLKKRFENDEIYTYIGHVLISVNPFKDLGIYTDEVLESYRGKNRYEVPPHVFALADSAYRNMKSEKENQCVIISGE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  181 SGAGKTVNTKRVIQYFATIAATGDlakKKDSKMKgtleDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLA 260
Cdd:cd01378     82 SGAGKTEASKRIMQYIAAVSGGSE---SEVERVK----DMLLASNPLLEAFGNAKTLRNDNSSRFGKYMEIQFDFKGEPV 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  261 SADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDIL 340
Cdd:cd01378    155 GGHITNYLLEKSRVVGQIKGERNFHIFYQLLKGASQEYLQELGLQRPEQYYYYSKSGCFDVDGIDDAADFKEVLNAMKVI 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  341 GFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDgTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEY---VTKGQT 417
Cdd:cd01378    235 GFTEEEQDSIFRILAAILHLGNIQFAEDEEGNAAISD-TSVLDFVAYLLGVDPDQLEKALTHRTIETGGGGrsvYEVPLN 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  418 VDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQ-HFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHhmFV 496
Cdd:cd01378    314 VEQAAYARDALAKAIYSRLFDWIVERINKSLAAKSGGKkKVIGVLDIYGFEIFEKNSFEQFCINYVNEKLQQIFIE--LT 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  497 L--EQEEYKKEGIEWTFIDFgMDLAACIELIE-KPMGIFSILEEECMFP-KATDTSFKNKLyDQHLGKSNNFQKPKVVKG 572
Cdd:cd01378    392 LkaEQEEYVREGIEWTPIKY-FNNKIICDLIEeKPPGIFAILDDACLTAgDATDQTFLQKL-NQLFSNHPHFECPSGHFE 469
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  573 RAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYatFATADADSGKKKVakkkgssfqTVSALF 652
Cdd:cd01378    470 LRRGEFRIKHYAGDVTYNVEGFLDKNKDLLFKDLKELMQSSSNPFLRSLF--PEGVDLDSKKRPP---------TAGTKF 538
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  653 RENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIP 732
Cdd:cd01378    539 KNSANALVETLMKKQPSYIRCIKPNDNKSPGEFDEELVLHQVKYLGLLENVRVRRAGFAYRQTYEKFLERYKLLSPKTWP 618
                          650       660       670
                   ....*....|....*....|....*....|....*
gi 2462555497  733 EGQFIDsKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd01378    619 AWDGTW-QGGVESILKDLNIPPEEYQMGKTKIFIR 652
MYSc_Myo22 cd14883
class XXII myosin, motor domain; These myosins possess an extended neck with multiple IQ ...
101-767 0e+00

class XXII myosin, motor domain; These myosins possess an extended neck with multiple IQ motifs such as found in class V, VIII, XI, and XIII myosins. These myosins are defined by two tandem MyTH4 and FERM domains. The apicomplexan, but not diatom myosins contain 4-6 WD40 repeats near the end of the C-terminal tail which suggests a possible function of these myosins in signal transduction and transcriptional regulation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276849 [Multi-domain]  Cd Length: 661  Bit Score: 607.01  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 180
Cdd:cd14883      2 GINTNLKVRYKKDLIYTYTGSILVAVNPYKELPIYTQDIVKQYFGKRMGALPPHIFALAEAAYTNMQEDGKNQSVIISGE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  181 SGAGKTVNTKRVIQYFAtiAATGdlakkKDSKmkgtLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLA 260
Cdd:cd14883     82 SGAGKTETTKLILQYLC--AVTN-----NHSW----VEQQILEANTILEAFGNAKTVRNDNSSRFGKFIEVCFDASGHIK 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  261 SADIETYLLEKSRVTFQLKAERSYHIFYQILSNKK--PELIELLLItTNPYDYPFISQ-GEILVASIDDAEELLATDSAI 337
Cdd:cd14883    151 GAIIQDYLLEQSRITFQAPGERNYHVFYQLLAGAKhsKELKEKLKL-GEPEDYHYLNQsGCIRIDNINDKKDFDHLRLAM 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  338 DILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAE-PDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQ 416
Cdd:cd14883    230 NVLGIPEEMQEGIFSVLSAILHLGNLTFEDIDGETGALtVEDKEILKIVAKLLGVDPDKLKKALTIRQINVRGNVTEIPL 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  417 TVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFV 496
Cdd:cd14883    310 KVQEARDNRDAMAKALYSRTFAWLVNHINSCTNPGQKNSRFIGVLDIFGFENFKVNSFEQLCINYTNEKLHKFFNHYVFK 389
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  497 LEQEEYKKEGIEWTFIDFgMDLAACIELIEK-PMGIFSILEEECMFPKATDTSFKNKLYDQHlGKSNNFQKPKvvKGRAE 575
Cdd:cd14883    390 LEQEEYEKEGINWSHIVF-TDNQECLDLIEKpPLGILKLLDEECRFPKGTDLTYLEKLHAAH-EKHPYYEKPD--RRRWK 465
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  576 AHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLY-----ATFATADADSGKKKVAKKKGSSFQTVSA 650
Cdd:cd14883    466 TEFGVKHYAGEVTYTVQGFLDKNKDTQQDDLFDLMSRSKNKFVKELFtypdlLALTGLSISLGGDTTSRGTSKGKPTVGD 545
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  651 LFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASA 730
Cdd:cd14883    546 TFKHQLQSLVDVLSATQPWYVRCIKPNSLKEPNVFDDELVLAQLRYAGMLEIIRIRKEGFPIHLTFKEFVDRYLCLDPRA 625
                          650       660       670
                   ....*....|....*....|....*....|....*..
gi 2462555497  731 IPEGQFIDsKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14883    626 RSADHKET-CGAVRALMGLGGLPEDEWQVGKTKVFLR 661
MYSc_Myo11 cd01384
class XI myosin, motor domain; These plant-specific type XI myosin are involved in organelle ...
100-767 0e+00

class XI myosin, motor domain; These plant-specific type XI myosin are involved in organelle transport. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle.


Pssm-ID: 276835  Cd Length: 647  Bit Score: 601.20  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILIT 178
Cdd:cd01384      1 PGVLHNLKVRYELDEIYTYTGNILIAVNPFKRLPhLYDAHMMEQYKGAPLGELSPHVFAVADAAYRAMINEGKSQSILVS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  179 GESGAGKTVNTKRVIQYFAtiaatgDLAKKKDSKMKgTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 258
Cdd:cd01384     81 GESGAGKTETTKMLMQYLA------YMGGRAVTEGR-SVEQQVLESNPLLEAFGNAKTVRNNNSSRFGKFVEIQFDDAGR 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  259 LASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTnPYDYPFISQGE-ILVASIDDAEELLATDSAI 337
Cdd:cd01384    154 ISGAAIRTYLLERSRVVQVSDPERNYHCFYQLCAGAPPEDREKYKLKD-PKQFHYLNQSKcFELDGVDDAEEYRATRRAM 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  338 DILGFTPEEKSGLYKLTGAVMHYGNMKFKqkqreEQAEPDGTEVADK--------TAYLMGLNSSDLLKALCFPRVKVGN 409
Cdd:cd01384    233 DVVGISEEEQDAIFRVVAAILHLGNIEFS-----KGEEDDSSVPKDEksefhlkaAAELLMCDEKALEDALCKRVIVTPD 307
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  410 EYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQF 489
Cdd:cd01384    308 GIITKPLDPDAATLSRDALAKTIYSRLFDWLVDKINRSIGQDPNSKRLIGVLDIYGFESFKTNSFEQFCINLANEKLQQH 387
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  490 FNHHMFVLEQEEYKKEGIEWTFIDFgMDLAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKLYDQhLGKSNNFQKPK 568
Cdd:cd01384    388 FNQHVFKMEQEEYTKEEIDWSYIEF-VDNQDVLDLIEkKPGGIIALLDEACMFPRSTHETFAQKLYQT-LKDHKRFSKPK 465
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  569 vvkgRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSgkkkvakkkGSSFQTV 648
Cdd:cd01384    466 ----LSRTDFTIDHYAGDVTYQTDLFLDKNKDYVVAEHQALLNASKCPFVAGLFPPLPREGTSS---------SSKFSSI 532
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  649 SALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLnA 728
Cdd:cd01384    533 GSRFKQQLQELMETLNTTEPHYIRCIKPNNLLKPGIFENANVLQQLRCGGVLEAVRISCAGYPTRKPFEEFLDRFGLL-A 611
                          650       660       670
                   ....*....|....*....|....*....|....*....
gi 2462555497  729 SAIPEGQFiDSKKACEKLLASIDIDhtQYKFGHTKVFFK 767
Cdd:cd01384    612 PEVLKGSD-DEKAACKKILEKAGLK--GYQIGKTKVFLR 647
MYSc_Myo42 cd14903
class XLII myosin, motor domain; The class XLII myosins are comprised of Stramenopiles. Not ...
100-767 3.80e-173

class XLII myosin, motor domain; The class XLII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276868 [Multi-domain]  Cd Length: 658  Bit Score: 542.06  E-value: 3.80e-173
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILIT 178
Cdd:cd14903      1 AAILYNVKKRFLRKLPYTYTGDICIAVNPYQWLPeLYTEEQHSKYLNKPKEELPPHVYATSVAAYNHMKRSGRNQSILVS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  179 GESGAGKTVNTKRVIQYFATIAatGDLakkKDSKMKgtledQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 258
Cdd:cd14903     81 GESGAGKTETTKILMNHLATIA--GGL---NDSTIK-----KIIEVNPLLESFGNAKTVRNDNSSRFGKFTQLQFDKNGT 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  259 LASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELiELLLITTNPYDYPFiSQGEILVASIDDAEELLATDSAID 338
Cdd:cd14903    151 LVGAKCRTYLLEKTRVISHERPERNYHIFYQLLASPDVEE-RLFLDSANECAYTG-ANKTIKIEGMSDRKHFARTKEALS 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  339 ILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAE--PDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQ 416
Cdd:cd14903    229 LIGVSEEKQEVLFEVLAGILHLGQLQIQSKPNDDEKSaiAPGDQGAVYATKLLGLSPEALEKALCSRTMRAAGDVYTVPL 308
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  417 TVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFV 496
Cdd:cd14903    309 KKDQAEDCRDALAKAIYSNVFDWLVATINASLGNDAKMANHIGVLDIFGFEHFKHNSFEQFCINYANEKLQQKFTQDVFK 388
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  497 LEQEEYKKEGIEWTFIDFgMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKgraeA 576
Cdd:cd14903    389 TVQIEYEEEGIRWAHIDF-ADNQDVLAVIEDRLGIISLLNDEVMRPKGNEESFVSKLSSIHKDEQDVIEFPRTSR----T 463
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  577 HFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLY---ATFATADADSGKKKVAKKKGSSF--QTVSAL 651
Cdd:cd14903    464 QFTIKHYAGPVTYESLGFLEKHKDALLPDLSDLMRGSSKPFLRMLFkekVESPAAASTSLARGARRRRGGALttTTVGTQ 543
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  652 FRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAi 731
Cdd:cd14903    544 FKDSLNELMTTIRSTNVHYVRCIKPNSIKSPTELDHLMVVSQLRCAGVIEAIRISRAAYPNRLLHEEFLDKFWLFLPEG- 622
                          650       660       670
                   ....*....|....*....|....*....|....*..
gi 2462555497  732 pEGQFIDSKKACEKLLASIDIDH-TQYKFGHTKVFFK 767
Cdd:cd14903    623 -RNTDVPVAERCEALMKKLKLESpEQYQMGLTRIYFQ 658
MYSc_Myo6 cd01382
class VI myosin, motor domain; Myosin VI is a monomeric myosin, which moves towards the ...
103-767 1.62e-170

class VI myosin, motor domain; Myosin VI is a monomeric myosin, which moves towards the minus-end of actin filaments, in contrast to most other myosins which moves towards the plus-end of actin filaments. It is thought that myosin VI, unlike plus-end directed myosins, does not use a pure lever arm mechanism, but instead steps with a mechanism analogous to the kinesin neck-linker uncoupling model. It has been implicated in a myriad of functions including: the transport of cytoplasmic organelles, maintenance of normal Golgi morphology, endocytosis, secretion, cell migration, border cell migration during development, and in cancer metastasis playing roles in deafness and retinal development among others. While how this is accomplished is largely unknown there are several interacting proteins that have been identified such as disabled homolog 2 (DAB2), GIPC1, synapse-associated protein 97 (SAP97; also known as DLG1) and optineurin, which have been found to target myosin VI to different cellular compartments. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the minus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276833  Cd Length: 649  Bit Score: 534.52  E-value: 1.62e-170
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  103 LYNLKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGES 181
Cdd:cd01382      4 LNNIRVRYSKDKIYTYVANILIAVNPYFDIPkLYSSETIKSYQGKSLGTLPPHVFAIADKAYRDMKVLKQSQSIIVSGES 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  182 GAGKTVNTKRVIQYFATIAATGDlakkkdskmkGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLAS 261
Cdd:cd01382     84 GAGKTESTKYILRYLTESWGSGA----------GPIEQRILEANPLLEAFGNAKTVRNNNSSRFGKFVEIHFNEKSSVVG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  262 ADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLittnpydypfisqgeiLVASIDDAEELLATDSAIDILG 341
Cdd:cd01382    154 GFVSHYLLEKSRICVQSKEERNYHIFYRLCAGAPEDLREKLL----------------KDPLLDDVGDFIRMDKAMKKIG 217
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  342 FTPEEKSGLYKLTGAVMHYGNMKFkqkqrEEQAEPD--GTEVADK-------TAYLMGLNSSDLLKALCfPRVKVGNEYV 412
Cdd:cd01382    218 LSDEEKLDIFRVVAAVLHLGNIEF-----EENGSDSggGCNVKPKseqsleyAAELLGLDQDELRVSLT-TRVMQTTRGG 291
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  413 TKGQ------TVDQVHHAVNALSKSVYEKLFLWMVTRINQQldtkLPRQ---HFIGVLDIAGFEIFEYNSLEQLCINFTN 483
Cdd:cd01382    292 AKGTvikvplKVEEANNARDALAKAIYSKLFDHIVNRINQC----IPFEtssYFIGVLDIAGFEYFEVNSFEQFCINYCN 367
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  484 EKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKLYDQHLgksN 562
Cdd:cd01382    368 EKLQQFFNERILKEEQELYEKEGLGVKEVEY-VDNQDCIDLIEaKLVGILDLLDEESKLPKPSDQHFTSAVHQKHK---N 443
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  563 NFQKPKVVKGRAEAH--------FSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGK 634
Cdd:cd01382    444 HFRLSIPRKSKLKIHrnlrddegFLIRHFAGAVCYETAQFIEKNNDALHASLESLICESKDKFIRSLFESSTNNNKDSKQ 523
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  635 KKVAKkkgsSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRI 714
Cdd:cd01382    524 KAGKL----SFISVGNKFKTQLNLLMDKLRSTGTSFIRCIKPNLKMTSHHFEGAQILSQLQCSGMVSVLDLMQGGFPSRT 599
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462555497  715 LYGDFKQRYRVLNASAIPEgqfIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd01382    600 SFHDLYNMYKKYLPPKLAR---LDPRLFCKALFKALGLNENDFKFGLTKVFFR 649
MYSc_Myo4 cd14872
class IV myosin, motor domain; These myosins all possess a WW domain either N-terminal or ...
100-767 3.10e-169

class IV myosin, motor domain; These myosins all possess a WW domain either N-terminal or C-terminal to their motor domain and a tail with a MyTH4 domain followed by a SH3 domain in some instances. The monomeric Acanthamoebas were the first identified members of this group and have been joined by Stramenopiles. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276839  Cd Length: 644  Bit Score: 530.89  E-value: 3.10e-169
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14872      1 AMIVHNLRKRFKNDQIYTNVGTILISVNPFKRLPLYTPTVMDQYMHKGPKEMPPHTYNIADDAYRAMIVDAMNQSILISG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATgdlakkkdskmKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 259
Cdd:cd14872     81 ESGAGKTEATKQCLSFFAEVAGS-----------TNGVEQRVLLANPILEAFGNAKTLRNNNSSRFGKWVEIHFDNRGRI 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  260 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSnkKPELIELLLITTNPyDYPFISQGEIL-VASIDDAEELLATDSAID 338
Cdd:cd14872    150 CGASTENYLLEKSRVVYQIKGERNFHIFYQLLA--SPDPASRGGWGSSA-AYGYLSLSGCIeVEGVDDVADFEEVVLAME 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  339 ILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGT---EVADKTAYLMGLNSSDLLKALCFPRVKVgneyvtKG 415
Cdd:cd14872    227 QLGFDDADINNVMSLIAAILKLGNIEFASGGGKSLVSGSTVanrDVLKEVATLLGVDAATLEEALTSRLMEI------KG 300
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  416 Q-------TVDQVHHAVNALSKSVYEKLFLWMVTRINQQLD-TKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQ 487
Cdd:cd14872    301 CdptriplTPAQATDACDALAKAAYSRLFDWLVKKINESMRpQKGAKTTFIGVLDIFGFEIFEKNSFEQLCINFTNEKLQ 380
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  488 QFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLAACIELIEK-PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSnnFQK 566
Cdd:cd14872    381 QHFNQYTFKLEEALYQSEGVKFEHIDF-IDNQPVLDLIEKkQPGLMLALDDQVKIPKGSDATFMIAANQTHAAKS--TFV 457
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  567 PKVVKGRaEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLyatFATADADSgkkkvakkkGSSFQ 646
Cdd:cd14872    458 YAEVRTS-RTEFIVKHYAGDVTYDITGFLEKNKDTLQKDLYVLLSSSKNKLIAVL---FPPSEGDQ---------KTSKV 524
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  647 TVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVL 726
Cdd:cd14872    525 TLGGQFRKQLSALMTALNATEPHYIRCVKPNQEKRARLFDGFMSLEQLRYAGVFEAVKIRKTGYPFRYSHERFLKRYRFL 604
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|.
gi 2462555497  727 NaSAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14872    605 V-KTIAKRVGPDDRQRCDLLLKSLKQDFSKVQVGKTRVLYR 644
MYSc_Myo29 cd14890
class XXIX myosin, motor domain; Class XXIX myosins are comprised of Stramenopiles and have ...
101-767 1.38e-168

class XXIX myosin, motor domain; Class XXIX myosins are comprised of Stramenopiles and have very long tail domains consisting of three IQ motifs, short coiled-coil regions, up to 18 CBS domains, a PB1 domain, and a carboxy-terminal transmembrane domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276855 [Multi-domain]  Cd Length: 662  Bit Score: 530.12  E-value: 1.38e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNPEVVEGYRGKKRQEAPPHIFSISDNAY-QFM---LTDRENQSI 175
Cdd:cd14890      2 SLLHTLRLRYERDEIYTYVGPILISINPYKSIPdLYSEERMLLYHGTTAGELPPHVFAIADHAYtQLIqsgVLDPSNQSI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  176 LITGESGAGKTVNTKRVIQYFATIAA--------TGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGK 247
Cdd:cd14890     82 IISGESGAGKTEATKIIMQYLARITSgfaqgasgEGEAASEAIEQTLGSLEDRVLSSNPLLESFGNAKTLRNDNSSRFGK 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  248 FIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTnPYDYPFISQGEILVASIDDA 327
Cdd:cd14890    162 FIEIQFDHHGKIVGAEISNFLLEKTRIVTQNDGERNYHIFYQLLAGADEALRERLKLQT-PVEYFYLRGECSSIPSCDDA 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  328 EELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGT-EVADKTAYLMGLNSSDLLKALCFPRVK 406
Cdd:cd14890    241 KAFAETIRCLSTIGISEENQDAVFGLLAAVLHLGNVDFESENDTTVLEDATTlQSLKLAAELLGVNEDALEKALLTRQLF 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  407 VGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKL 486
Cdd:cd14890    321 VGGKTIVQPQNVEQARDKRDALAKALYSSLFLWLVSELNRTISSPDDKWGFIGVLDIYGFEKFEWNTFEQLCINYANEKL 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  487 QQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLAACIELIE-----KPmGIFSILEEECMFPKA-TDTSFKNKLYDQHLGK 560
Cdd:cd14890    401 QRHFNQHMFEVEQVEYSNEGIDWQYITF-NDNQACLELIEgkvngKP-GIFITLDDCWRFKGEeANKKFVSQLHASFGRK 478
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  561 SN------------NFQKPKVVKGRaeaHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLlahlyatfata 628
Cdd:cd14890    479 SGsggtrrgssqhpHFVHPKFDADK---QFGIKHYAGDVIYDASGFNEKNNETLNAEMKELIKQSRRSI----------- 544
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  629 dadsgkkkvakkKGSSfqtVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRK 708
Cdd:cd14890    545 ------------REVS---VGAQFRTQLQELMAKISLTNPRYVRCIKPNETKAPGKFDGLDCLRQLKYSGMMEAIQIRQQ 609
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  709 GFPNRILYGDFKQRYRVLNASAipegqfiDSKKACEKLLASI-DIDHTQYKFGHTKVFFK 767
Cdd:cd14890    610 GFALREEHDSFFYDFQVLLPTA-------ENIEQLVAVLSKMlGLGKADWQIGSSKIFLK 662
MYSc_Myo15 cd01387
class XV mammal-like myosin, motor domain; The class XV myosins are monomeric. In vertebrates, ...
101-767 4.98e-166

class XV mammal-like myosin, motor domain; The class XV myosins are monomeric. In vertebrates, myosin XV appears to be expressed in sensory tissue and play a role in hearing. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to the head domain are 2 MyTH4 domain, a FERM domain, and a SH3 domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276838 [Multi-domain]  Cd Length: 657  Bit Score: 522.78  E-value: 4.98e-166
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGE 180
Cdd:cd01387      2 TVLWNLKTRYERNLIYTYIGSILVSVNPYKMFDIYGLEQVQQYSGRALGELPPHLFAIANLAFAKMLDAKQNQCVVISGE 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  181 SGAGKTVNTKRVIQYFATIAATGDlakkkdskmkGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFgTTGKLA 260
Cdd:cd01387     82 SGSGKTEATKLIMQYLAAVNQRRN----------NLVTEQILEATPLLEAFGNAKTVRNDNSSRFGKYLEVFF-EGGVIV 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  261 SADIETYLLEKSRVTFQLKAERSYHIFYQIL---SNKKPELIELLlittNPYDYPFISQG-EILVASIDDAEELLATDSA 336
Cdd:cd01387    151 GAITSQYLLEKSRIVTQAKNERNYHVFYELLaglPAQLRQKYGLQ----EAEKYFYLNQGgNCEIAGKSDADDFRRLLAA 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  337 IDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEpdGTEVADK-----TAYLMGLNSSDLLKALCFPRVKVGNEY 411
Cdd:cd01387    227 MQVLGFSSEEQDSIFRILASVLHLGNVYFHKRQLRHGQE--GVSVGSDaeiqwVAHLLQISPEGLQKALTFKVTETRRER 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  412 VTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFN 491
Cdd:cd01387    305 IFTPLTIDQALDARDAIAKALYALLFSWLVTRVNAIVYSGTQDTLSIAILDIFGFEDLSENSFEQLCINYANENLQYYFN 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  492 HHMFVLEQEEYKKEGIEWTFIDFgMDLAACIELI-EKPMGIFSILEEECMFPKATDTSFKNKLYDQHlGKSNNFQKPKVv 570
Cdd:cd01387    385 KHVFKLEQEEYIREQIDWTEIAF-ADNQPVINLIsKKPVGILHILDDECNFPQATDHSFLEKCHYHH-ALNELYSKPRM- 461
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  571 kGRAEahFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFAtadADSGKKKVAKKKGSSFQ---- 646
Cdd:cd01387    462 -PLPE--FTIKHYAGQVWYQVHGFLDKNRDQLRQDVLELLVSSRTRVVAHLFSSHR---AQTDKAPPRLGKGRFVTmkpr 535
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  647 --TVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYR 724
Cdd:cd01387    536 tpTVAARFQDSLLQLLEKMERCNPWFVRCLKPNHKKEPMLFDMDVVMAQLRYSGMLETIRIRKEGYPVRLPFQVFIDRYR 615
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|...
gi 2462555497  725 VLNASAIPEGQFIDSKKACEKLLASIDIDhTQYKFGHTKVFFK 767
Cdd:cd01387    616 CLVALKLPRPAPGDMCVSLLSRLCTVTPK-DMYRLGATKVFLR 657
MYSc_Myo9 cd01385
class IX myosin, motor domain; Myosin IX is a processive single-headed motor, which might play ...
103-767 3.50e-164

class IX myosin, motor domain; Myosin IX is a processive single-headed motor, which might play a role in signalling. It has a N-terminal RA domain, an IQ domain, a C1_1 domain, and a RhoGAP domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276836 [Multi-domain]  Cd Length: 690  Bit Score: 518.85  E-value: 3.50e-164
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  103 LYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESG 182
Cdd:cd01385      4 LENLRARFKHGKIYTYVGSILIAVNPFKFLPIYNPKYVKMYQNRRLGKLPPHIFAIADVAYHAMLRKKKNQCIVISGESG 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  183 AGKTVNTKRVIQYFATIAatgdlakkkdskMKGT---LEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 259
Cdd:cd01385     84 SGKTESTNFLLHHLTALS------------QKGYgsgVEQTILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYRENGMV 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  260 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSN-KKPELIELLLITtnPYDYPFISQGEILVA-SIDDAEELLATDSAI 337
Cdd:cd01385    152 RGAVVEKYLLEKSRIVSQEKNERNYHVFYYLLAGaSEEERKELHLKQ--PEDYHYLNQSDCYTLeGEDEKYEFERLKQAM 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  338 DILGFTPEEKSGLYKLTGAVMHYGNMKFKQK--QREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKG 415
Cdd:cd01385    230 EMVGFLPETQRQIFSVLSAVLHLGNIEYKKKayHRDESVTVGNPEVLDIISELLRVKEETLLEALTTKKTVTVGETLILP 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  416 QTVDQVHHAVNALSKSVYEKLFLWMVTRINQQL----DTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFN 491
Cdd:cd01385    310 YKLPEAIATRDAMAKCLYSALFDWIVLRINHALlnkkDLEEAKGLSIGVLDIFGFEDFGNNSFEQFCINYANEHLQYYFN 389
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  492 HHMFVLEQEEYKKEGIEWTFIDFgMDLAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKlYDQHLGKSNNFQKPKVV 570
Cdd:cd01385    390 QHIFKLEQEEYKKEGISWHNIEY-TDNTGCLQLISkKPTGLLCLLDEESNFPGATNQTLLAK-FKQQHKDNKYYEKPQVM 467
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  571 kgraEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLL--------------AHLYATFATADA--DSGK 634
Cdd:cd01385    468 ----EPAFIIAHYAGKVKYQIKDFREKNLDLMRPDIVAVLRSSSSAFVreligidpvavfrwAVLRAFFRAMAAfrEAGR 543
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  635 KKVAKKKGSSF-------------------QTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLR 695
Cdd:cd01385    544 RRAQRTAGHSLtlhdrttksllhlhkkkkpPSVSAQFQTSLSKLMETLGQAEPFFIRCIKSNAEKKPLRFDDELVLRQLR 623
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462555497  696 CNGVLEGIRICRKGFPNRILYGDFKQRYRVLnasaIPEGQfIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd01385    624 YTGMLETVRIRRSGYSVRYTFQEFITQFQVL----LPKGL-ISSKEDIKDFLEKLNLDRDNYQIGKTKVFLK 690
MYSc_Myo3 cd01379
class III myosin, motor domain; Myosin III has been shown to play a role in the vision process ...
100-767 7.32e-164

class III myosin, motor domain; Myosin III has been shown to play a role in the vision process in insects and in hearing in mammals. Myosin III, an unconventional myosin, does not form dimers. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. They are characterized by an N-terminal protein kinase domain and several IQ domains. Some members also contain WW, SH2, PH, and Y-phosphatase domains. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276830 [Multi-domain]  Cd Length: 633  Bit Score: 516.06  E-value: 7.32e-164
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd01379      1 DTIVSQLQKRYSRDQIYTYIGDILIAVNPFQNLGIYTEEHSRLYRGAKRSDNPPHIFAVADAAYQAMIHQKKNQCIVISG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFAtiaatgDLAKKKDskmkGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 259
Cdd:cd01379     81 ESGAGKTESANLLVQQLT------VLGKANN----RTLEEKILQVNPLMEAFGNARTVINDNSSRFGKYLEMKFTSTGAV 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  260 ASADIETYLLEKSRVTFQLKAERSYHIFYQIL----SNKKpeLIELLLITTNPYDYPFISQGEILVASIDDA--EELLAT 333
Cdd:cd01379    151 TGARISEYLLEKSRVVHQAIGERNFHIFYYIYaglaEDKK--LAKYKLPENKPPRYLQNDGLTVQDIVNNSGnrEKFEEI 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  334 DSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQ----AEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGN 409
Cdd:cd01379    229 EQCFKVIGFTKEEVDSVYSILAAILHIGDIEFTEVESNHQtdksSRISNPEALNNVAKLLGIEADELQEALTSHSVVTRG 308
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  410 EYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQL--DTKLP-RQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKL 486
Cdd:cd01379    309 ETIIRNNTVEEATDARDAMAKALYGRLFSWIVNRINSLLkpDRSASdEPLSIGILDIFGFENFQKNSFEQLCINIANEQI 388
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  487 QQFFNHHMFVLEQEEYKKEGIEWTFIDFG-----MDLaacieLIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHlgKS 561
Cdd:cd01379    389 QYYFNQHIFAWEQQEYLNEGIDVDLIEYEdnrplLDM-----FLQKPMGLLALLDEESRFPKATDQTLVEKFHNNI--KS 461
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  562 NNFQKPKvvkgRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAhlyatfatadadsgkkkvakkk 641
Cdd:cd01379    462 KYYWRPK----SNALSFGIHHYAGKVLYDASGFLEKNRDTLPPDVVQLLRSSENPLVR---------------------- 515
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  642 gssfQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQ 721
Cdd:cd01379    516 ----QTVATYFRYSLMDLLSKMVVGQPHFVRCIKPNDSRQAGKFDREKVLKQLRYTGVLETTRIRRQGFSHRILFADFLK 591
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*...
gi 2462555497  722 RYRVL--NASAIPEGqfidSKKACEKLLASIDIDHtqYKFGHTKVFFK 767
Cdd:cd01379    592 RYYFLafKWNEEVVA----NRENCRLILERLKLDN--WALGKTKVFLK 633
MYSc_Myo27 cd14888
class XXVII myosin, motor domain; Not much is known about this myosin class. The catalytic ...
100-767 1.17e-163

class XXVII myosin, motor domain; Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276853 [Multi-domain]  Cd Length: 667  Bit Score: 516.55  E-value: 1.17e-163
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNPEVVEGYRgKKRQEAPPHIFSISDNAYQFMLTDRENQSILIT 178
Cdd:cd14888      1 ASILHSLNLRFDIDEIYTFTGPILIAVNPFKTIPgLYSDEMLLKFI-QPSISKSPHVFSTASSAYQGMCNNKKSQTILIS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  179 GESGAGKTVNTKRVIQYFATiaatgdlAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF----- 253
Cdd:cd14888     80 GESGAGKTESTKYVMKFLAC-------AGSEDIKKRSLVEAQVLESNPLLEAFGNARTLRNDNSSRFGKFIELQFsklks 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  254 ----GTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTN-----------PYDYPFISQGE 318
Cdd:cd14888    153 krmsGDRGRLCGAKIQTYLLEKVRVCDQQEGERNYHIFYQLCAAAREAKNTGLSYEENdeklakgadakPISIDMSSFEP 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  319 ILV------------ASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQA---EPDGTEVAD 383
Cdd:cd14888    233 HLKfryltksschelPDVDDLEEFESTLYAMQTVGISPEEQNQIFSIVAAILYLGNILFENNEACSEGavvSASCTDDLE 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  384 KTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLD-TKLPRQHFIGVLD 462
Cdd:cd14888    313 KVASLLGVDAEDLLNALCYRTIKTAHEFYTKPLRVDEAEDVRDALARALYSCLFDKVVERTNESIGySKDNSLLFCGVLD 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  463 IAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLAACIELI-EKPMGIFSILEEECMF 541
Cdd:cd14888    393 IFGFECFQLNSFEQLCINFTNERLQQFFNNFVFKCEEKLYIEEGISWNPLDFP-DNQDCVDLLqEKPLGIFCMLDEECFV 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  542 PKATDTSFKNKLYDQHLGkSNNFqkpKVVKGRAEAhFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHL 621
Cdd:cd14888    472 PGGKDQGLCNKLCQKHKG-HKRF---DVVKTDPNS-FVIVHFAGPVKYCSDGFLEKNKDQLSVDAQEVIKNSKNPFISNL 546
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  622 YATFATADADSGKKKVAkkkgssFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLE 701
Cdd:cd14888    547 FSAYLRRGTDGNTKKKK------FVTVSSEFRNQLDVLMETIDKTEPHFIRCIKPNSQNVPDLFDRISVNEQLKYGGVLQ 620
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462555497  702 GIRICRKGFPNRILYGDFKQRYRVLnasAIPEGQfidskkacekllasidIDHTQYKFGHTKVFFK 767
Cdd:cd14888    621 AVQVSRAGYPVRLSHAEFYNDYRIL---LNGEGK----------------KQLSIWAVGKTLCFFK 667
MYSc_Myo40 cd14901
class XL myosin, motor domain; The class XL myosins are comprised of Stramenopiles. Not much ...
100-765 8.12e-162

class XL myosin, motor domain; The class XL myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276866 [Multi-domain]  Cd Length: 655  Bit Score: 511.26  E-value: 8.12e-162
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGY------RGKKRQEAPPHIFSISDNAYQFMLTDRE-- 171
Cdd:cd14901      1 PSILHVLRRRFAHGLIYTSTGAILVAINPFRRLPLYDDETKEAYyehgerRAAGERKLPPHVYAVADKAFRAMLFASRgq 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  172 --NQSILITGESGAGKTVNTKRVIQYFAtiAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFI 249
Cdd:cd14901     81 kcDQSILVSGESGAGKTETTKIIMNYLA--SVSSATTHGQNATERENVRDRVLESNPILEAFGNARTNRNNNSSRFGKFI 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  250 RIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKP-ELIELLLITTNPYDYPFISQGEILVASIDDAE 328
Cdd:cd14901    159 RLGFASSGSLLGASISTYLLERVRLVSQAKGERNYHIFYELLRGASSdELHALGLTHVEEYKYLNSSQCYDRRDGVDDSV 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  329 ELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEV-ADKTAYLMGLNSSDLLKALCFPRVKV 407
Cdd:cd14901    239 QYAKTRHAMTTIGMSPDEQISVLQLVAAVLHLGNLCFVKKDGEGGTFSMSSLAnVRAACDLLGLDMDVLEKTLCTREIRA 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  408 GNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLP--RQHFIGVLDIAGFEIFEYNSLEQLCINFTNEK 485
Cdd:cd14901    319 GGEYITMPLSVEQALLTRDVVAKTLYAQLFDWLVDRINESIAYSEStgASRFIGIVDIFGFEIFATNSLEQLCINFANEK 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  486 LQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDlAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKLYDQhLGKSNNF 564
Cdd:cd14901    399 LQQLFGKFVFEMEQDEYVAEAIPWTFVEYPNN-DACVAMFEaRPTGLFSLLDEQCLLPRGNDEKLANKYYDL-LAKHASF 476
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  565 QKPKVVKGRAEahFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAhlyatfatadadsgkkkvakkkgss 644
Cdd:cd14901    477 SVSKLQQGKRQ--FVIHHYAGAVCYATDGFCDKNKDHVHSEALALLRTSSNAFLS------------------------- 529
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  645 fQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYR 724
Cdd:cd14901    530 -STVVAKFKVQLSSLLEVLNATEPHFIRCIKPNDVLSPSEFDAKRVLEQLRCSGVLEAVKISRSGYPVRFPHDAFVHTYS 608
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 2462555497  725 VLNAS------AIPEGQFIDSKKACEKLLASIDIDHTQykFGHTKVF 765
Cdd:cd14901    609 CLAPDgasdtwKVNELAERLMSQLQHSELNIEHLPPFQ--VGKTKVF 653
MYSc_Myo31 cd14892
class XXXI myosin, motor domain; Class XXXI myosins have a very long neck region consisting of ...
106-767 8.19e-158

class XXXI myosin, motor domain; Class XXXI myosins have a very long neck region consisting of 17 IQ motifs and 2 tandem ANK repeats that are separated by a PH domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276857 [Multi-domain]  Cd Length: 656  Bit Score: 500.44  E-value: 8.19e-158
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  106 LKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNpevVEGYRGKKRQEA-----PPHIFSISDNAYQFMLTDR----ENQSI 175
Cdd:cd14892      7 LRRRYERDAIYTFTADILISINPYKSIPlLYD---VPGFDSQRKEEAtasspPPHVFSIAERAYRAMKGVGkgqgTPQSI 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  176 LITGESGAGKTVNTKRVIQYFATI--AATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF 253
Cdd:cd14892     84 VVSGESGAGKTEASKYIMKYLATAskLAKGASTSKGAANAHESIEECVLLSNLILEAFGNAKTIRNDNSSRFGKYIQIHY 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  254 GTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPyDYPFISQGEIL-VASIDDAEELLA 332
Cdd:cd14892    164 NSDGRIAGASTDHFLLEKSRLVGPDANERNYHIFYQLLAGLDANENAALELTPAE-SFLFLNQGNCVeVDGVDDATEFKQ 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  333 TDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVAD--KTAYLMGLNSSDLLKALCFpRVKVGne 410
Cdd:cd14892    243 LRDAMEQLGFDAEFQRPIFEVLAAVLHLGNVRFEENADDEDVFAQSADGVNvaKAAGLLGVDAAELMFKLVT-QTTST-- 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  411 yvTKGQ------TVDQVHHAVNALSKSVYEKLFLWMVTRIN----QQL------DTKLPRQHFIGVLDIAGFEIFEYNSL 474
Cdd:cd14892    320 --ARGSvleiklTAREAKNALDALCKYLYGELFDWLISRINachkQQTsgvtggAASPTFSPFIGILDIFGFEIMPTNSF 397
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  475 EQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLAACIELIEK-PMGIFSILEEECMFP-KATDTSFKNK 552
Cdd:cd14892    398 EQLCINFTNEMLQQQFNKHVFVLEQEVYASEGIDVSAIEF-QDNQDCLDLIQKkPLGLLPLLEEQMLLKrKTTDKQLLTI 476
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  553 LYDQHLGKSNNFQKPkvvkgRAEA-HFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNrllahlyatfatadad 631
Cdd:cd14892    477 YHQTHLDKHPHYAKP-----RFECdEFVLRHYAGDVTYDVHGFLAKNNDNLHDDLRDLLRSSSK---------------- 535
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  632 sgkkkvakkkgssfqtvsalFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFP 711
Cdd:cd14892    536 --------------------FRTQLAELMEVLWSTTPSYIKCIKPNNLKFPGGFSCELVRDQLIYSGVLEVVRIRREGFP 595
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462555497  712 NRILYGDFKQRYRVL-------NASAIPEGQFIDSKKACEKLLASIDIDHTQykFGHTKVFFK 767
Cdd:cd14892    596 IRRQFEEFYEKFWPLarnkagvAASPDACDATTARKKCEEIVARALERENFQ--LGRTKVFLR 656
MYSc_Myo10 cd14873
class X myosin, motor domain; Myosin X is an unconventional myosin motor that functions as a ...
101-767 1.80e-156

class X myosin, motor domain; Myosin X is an unconventional myosin motor that functions as a monomer. In mammalian cells, the motor is found to localize to filopodia. Myosin X walks towards the barbed ends of filaments and is thought to walk on bundles of actin, rather than single filaments, a unique behavior. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to the head domain are a variable number of IQ domains, 2 PH domains, a MyTH4 domain, and a FERM domain. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276840 [Multi-domain]  Cd Length: 651  Bit Score: 496.62  E-value: 1.80e-156
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14873      2 SIMYNLFQRYKRNQIYTYIGSILASVNPYQPIAgLYEPATMEQYSRRHLGELPPHIFAIANECYRCLWKRHDNQCILISG 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGdlAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 259
Cdd:cd14873     82 ESGAGKTESTKLILKFLSVISQQS--LELSLKEKTSCVEQAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNICQKGNI 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  260 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTnPYDYPFISQ-GEILVASIDDAEELLATDSAID 338
Cdd:cd14873    160 QGGRIVDYLLEKNRVVRQNPGERNYHIFYALLAGLEHEEREEFYLST-PENYHYLNQsGCVEDKTISDQESFREVITAME 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  339 ILGFTPEEKSGLYKLTGAVMHYGNMKFkqkqreeqAEPDGTEVADKTAY-----LMGLNSSDLLKALCFPRVKVGNEYVT 413
Cdd:cd14873    239 VMQFSKEEVREVSRLLAGILHLGNIEF--------ITAGGAQVSFKTALgrsaeLLGLDPTQLTDALTQRSMFLRGEEIL 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  414 KGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKlPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHH 493
Cdd:cd14873    311 TPLNVQQAVDSRDSLAMALYARCFEWVIKKINSRIKGK-EDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKH 389
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  494 MFVLEQEEYKKEGIEWTFIDFgMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHlgkSNN--FQKPKVvk 571
Cdd:cd14873    390 IFSLEQLEYSREGLVWEDIDW-IDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLHSQH---ANNhfYVKPRV-- 463
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  572 grAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSnrlLAHLYATFATADADSGKKKVAKKKGSSFQTVSAL 651
Cdd:cd14873    464 --AVNNFGVKHYAGEVQYDVRGILEKNRDTFRDDLLNLLRESR---FDFIYDLFEHVSSRNNQDTLKCGSKHRRPTVSSQ 538
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  652 FRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVL-NASA 730
Cdd:cd14873    539 FKDSLHSLMATLSSSNPFFVRCIKPNMQKMPDQFDQAVVLNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLmRNLA 618
                          650       660       670
                   ....*....|....*....|....*....|....*..
gi 2462555497  731 IPEgqfiDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14873    619 LPE----DVRGKCTSLLQLYDASNSEWQLGKTKVFLR 651
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
847-1924 1.11e-155

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 508.95  E-value: 1.11e-155
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTER 926
Cdd:pfam01576    4 EEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELESR 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  927 AEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQ 1006
Cdd:pfam01576   84 LEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLLEERISE 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1007 ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDF 1086
Cdd:pfam01576  164 FTSNLAEEEEKAKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEE 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1087 EYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK 1166
Cdd:pfam01576  244 ELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQELRS 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1167 KREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANL 1246
Cdd:pfam01576  324 KREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDS 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1247 EKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKA 1326
Cdd:pfam01576  404 EHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQ 483
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1327 KNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAiQRTEELEEAKKKLAQRLQDSEEQVE 1406
Cdd:pfam01576  484 KLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDA-GTLEALEEGKKRLQRELEALTQQLE 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1407 AVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKC-----EESQAELEASLKESRSLSte 1481
Cdd:pfam01576  563 EKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAISaryaeERDRAEAEAREKETRALS-- 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1482 lfkLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILR 1561
Cdd:pfam01576  641 ---LARALEEALEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLR 717
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1562 IQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETL 1641
Cdd:pfam01576  718 LEVNMQALKAQFERDLQARDEQGEEKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIDAANKGREEAV 797
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1642 KHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQN 1721
Cdd:pfam01576  798 KQLKKLQAQMKDLQRELEEARASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELADEIASGASGK 877
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1722 TSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA 1801
Cdd:pfam01576  878 SALQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQKSESARQQLERQNKELKAKLQEM 957
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1802 EQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKR 1881
Cdd:pfam01576  958 EGTVKSKFKSSIAALEAKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKR 1037
                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|...
gi 2462555497 1882 QAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAK 1924
Cdd:pfam01576 1038 QLEEAEEEASRANAARRKLQRELDDATESNESMNREVSTLKSK 1080
MYSc_Myo36 cd14897
class XXXVI myosin, motor domain; This class of molluscan myosins contains a motor domain ...
102-767 6.36e-147

class XXXVI myosin, motor domain; This class of molluscan myosins contains a motor domain followed by a GlcAT-I (Beta1,3-glucuronyltransferase I) domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276862 [Multi-domain]  Cd Length: 635  Bit Score: 469.56  E-value: 6.36e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  102 VLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKK-RQEAPPHIFSISDNAYQFMLTDRENQSILITGE 180
Cdd:cd14897      3 IVQTLKSRYNKDKFYTYIGDILVAVNPCKPLPIFDKKHHEEYSNLSvRSQRPPHLFWIADQAYRRLLETGRNQCILVSGE 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  181 SGAGKTVNTKRVIQYFATIAATGDlakkkdskmkGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLA 260
Cdd:cd14897     83 SGAGKTESTKYMIKHLMKLSPSDD----------SDLLDKIVQINPLLEAFGNASTVMNDNSSRFGKFIELHFTENGQLL 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  261 SADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLItTNPYDYPFISQGEILVASIDDAEEL----LATDSA 336
Cdd:cd14897    153 GAKIDDYLLEKSRVVHRGNGEKNFHIFYALFAGMSRDRLLYYFL-EDPDCHRILRDDNRNRPVFNDSEELeyyrQMFHDL 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  337 IDIL---GFTPEEKSGLYKLTGAVMHYGNMKFkqkqrEEQAEPDGTEVADKT-----AYLMGLNSSDLLKALCFPRVKVG 408
Cdd:cd14897    232 TNIMkliGFSEEDISVIFTILAAILHLTNIVF-----IPDEDTDGVTVADEYplhavAKLLGIDEVELTEALISNVNTIR 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  409 NEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHF-----IGVLDIAGFEIFEYNSLEQLCINFTN 483
Cdd:cd14897    307 GERIQSWKSLRQANDSRDALAKDLYSRLFGWIVGQINRNLWPDKDFQIMtrgpsIGILDMSGFENFKINSFDQLCINLSN 386
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  484 EKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLAACIELI-EKPMGIFSILEEECMFPKATDTSFKNKLYDqHLGKSN 562
Cdd:cd14897    387 ERLQQYFNDYVFPRERSEYEIEGIEWRDIEY-HDNDDVLELFfKKPLGILPLLDEESTFPQSTDSSLVQKLNK-YCGESP 464
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  563 NFQKPKvvKGRAEahFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFatadadsgkkkvakkkg 642
Cdd:cd14897    465 RYVASP--GNRVA--FGIRHYAEQVTYDADGFLEKNRDNLSSDIVGCLLNSNNEFISDLFTSY----------------- 523
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  643 ssfqtvsalFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQR 722
Cdd:cd14897    524 ---------FKRSLSDLMTKLNSADPLFVRCIKPNNFLRPNKFDDELVRRQLLCNGLMEIAKIRRDGYPIRIKYEDFVKR 594
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*
gi 2462555497  723 YRVLNASaiPEGQFIDSKKACEKLLASIDIDhtQYKFGHTKVFFK 767
Cdd:cd14897    595 YKEICDF--SNKVRSDDLGKCQKILKTAGIK--GYQFGKTKVFLK 635
MYSc_Myo39 cd14900
class XXXIX myosin, motor domain; The class XXXIX myosins are found in Stramenopiles. Not much ...
102-753 2.00e-146

class XXXIX myosin, motor domain; The class XXXIX myosins are found in Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276865  Cd Length: 627  Bit Score: 467.86  E-value: 2.00e-146
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  102 VLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNPEVVEGY-----------RGKKRQEAPPHIFSISDNAYQFM--- 166
Cdd:cd14900      3 ILSALETRFYAQKIYTNTGAILLAVNPFQKLPgLYSSDTMAKYllsfearssstRNKGSDPMPPHIYQVAGEAYKAMmlg 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  167 -LTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRF 245
Cdd:cd14900     83 lNGVMSDQSILVSGESGSGKTESTKFLMEYLAQAGDNNLAASVSMGKSTSGIAAKVLQTNILLESFGNARTLRNDNSSRF 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  246 GKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILsnkkpelielllittnpydypfisqgeilvasID 325
Cdd:cd14900    163 GKFIKLHFTSGGRLTGASIQTYLLEKVRLVSQSKGERNYHIFYEMA--------------------------------IG 210
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  326 DAEELLATD------SAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVA-------DKTAYLMGLN 392
Cdd:cd14900    211 ASEAARKRDmyrrvmDAMDIIGFTPHERAGIFDLLAALLHIGNLTFEHDENSDRLGQLKSDLApssiwsrDAAATLLSVD 290
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  393 SSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQL-----DTKLPRQHFIGVLDIAGFE 467
Cdd:cd14900    291 ATKLEKALSVRRIRAGTDFVSMKLSAAQANNARDALAKALYGRLFDWLVGKMNAFLkmddsSKSHGGLHFIGILDIFGFE 370
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  468 IFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLAACIELI-EKPMGIFSILEEECMFPKATD 546
Cdd:cd14900    371 VFPKNSFEQLCINFANETLQQQFNDYVFKAEQREYESQGVDWKYVEF-CDNQDCVNLIsQRPTGILSLIDEECVMPKGSD 449
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  547 TSFKNKLYdQHLGKSNNFQKPKVVKGRaeAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNrllahlyatfa 626
Cdd:cd14900    450 TTLASKLY-RACGSHPRFSASRIQRAR--GLFTIVHYAGHVEYSTDGFLEKNKDVLHQEAVDLFVYGLQ----------- 515
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  627 tadadsgkkkvakkkgssfqtvsalFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRIC 706
Cdd:cd14900    516 -------------------------FKEQLTTLLETLQQTNPHYVRCLKPNDLCKAGIYERERVLNQLRCNGVMEAVRVA 570
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 2462555497  707 RKGFPNRILYGDFKQRYRVLNASAIPegqfidsKKACEKLLASIDID 753
Cdd:cd14900    571 RAGFPIRLLHDEFVARYFSLARAKNR-------LLAKKQGTSLPDTD 610
MYSc_Myo43 cd14904
class XLIII myosin, motor domain; The class XLIII myosins are comprised of Stramenopiles. Not ...
100-767 7.60e-143

class XLIII myosin, motor domain; The class XLIII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276869  Cd Length: 653  Bit Score: 459.02  E-value: 7.60e-143
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILIT 178
Cdd:cd14904      1 PSILFNLKKRFAASKPYTYTNDIVIALNPYKWIDnLYGDHLHEQYLKKPRDKLQPHVYATSTAAYKHMLTNEMNQSILVS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  179 GESGAGKTVNTKRVIQYFATIAAtgdlaKKKDSKMkgtleDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 258
Cdd:cd14904     81 GESGAGKTETTKIVMNHLASVAG-----GRKDKTI-----AKVIDVNPLLESFGNAKTTRNDNSSRFGKFTQLQFDGRGK 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  259 LASADIETYLLEKSRVTFQLKAERSYHIFYQILSN-KKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAI 337
Cdd:cd14904    151 LIGAKCETYLLEKSRVVSIAEGERNYHIFYQLLAGlSSEERKEFGLDPNCQYQYLGDSLAQMQIPGLDDAKLFASTQKSL 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  338 DILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVAdKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQT 417
Cdd:cd14904    231 SLIGLDNDAQRTLFKILSGVLHLGEVMFDKSDENGSRISNGSQLS-QVAKMLGLPTTRIEEALCNRSVVTRNESVTVPLA 309
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  418 VDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPR-QHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFV 496
Cdd:cd14904    310 PVEAEENRDALAKAIYSKLFDWMVVKINAAISTDDDRiKGQIGVLDIFGFEDFAHNGFEQFCINYANEKLQQKFTTDVFK 389
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  497 LEQEEYKKEGIEWTFIDFgMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQH--LGKSNNFQKPKVVKgra 574
Cdd:cd14904    390 TVEEEYIREGLQWDHIEY-QDNQGIVEVIDGKMGIIALMNDHLRQPRGTEEALVNKIRTNHqtKKDNESIDFPKVKR--- 465
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  575 eAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLyatFATADADSGKKKVAKKKG-SSFQTVSALFR 653
Cdd:cd14904    466 -TQFIINHYAGPVTYETVGFMEKHRDTLQNDLLDLVLLSSLDLLTEL---FGSSEAPSETKEGKSGKGtKAPKSLGSQFK 541
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  654 ENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPE 733
Cdd:cd14904    542 TSLSQLMDNIKTTNTHYVRCIKPNANKSPTEFDKRMVVEQLRSAGVIEAIRITRSGYPSRLTPKELATRYAIMFPPSMHS 621
                          650       660       670
                   ....*....|....*....|....*....|....*
gi 2462555497  734 GqfiDSKKACEKLLASIDIDHT-QYKFGHTKVFFK 767
Cdd:cd14904    622 K---DVRRTCSVFMTAIGRKSPlEYQIGKSLIYFK 653
MYSc_Myo46 cd14907
class XLVI myosin, motor domain; The class XLVI myosins are comprised of Alveolata. Not much ...
102-767 1.19e-141

class XLVI myosin, motor domain; The class XLVI myosins are comprised of Alveolata. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276872 [Multi-domain]  Cd Length: 669  Bit Score: 456.41  E-value: 1.19e-141
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  102 VLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNPEVVEGYRG--KKRQEA------PPHIFSISDNAYQFMLTDREN 172
Cdd:cd14907      3 LLINLKKRYQQDKIFTYVGPTLIVMNPYKQIDnLFSEEVMQMYKEqiIQNGEYfdikkePPHIYAIAALAFKQLFENNKK 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  173 QSILITGESGAGKTVNTKRVIQYFATIAA---------TGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSS 243
Cdd:cd14907     83 QAIVISGESGAGKTENAKYAMKFLTQLSQqeqnseevlTLTSSIRATSKSTKSIEQKILSCNPILEAFGNAKTVRNDNSS 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  244 RFGKFIRIHFG-TTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYP--FISQGEIL 320
Cdd:cd14907    163 RFGKYVSILVDkKKRKILGARIQNYLLEKSRVTQQGQGERNYHIFYHLLYGADQQLLQQLGLKNQLSGDRydYLKKSNCY 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  321 -VASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQ--REEQAEPDGTEVADKTAYLMGLNSSDLL 397
Cdd:cd14907    243 eVDTINDEKLFKEVQQSFQTLGFTEEEQDSIWRILAAILLLGNLQFDDSTldDNSPCCVKNKETLQIIAKLLGIDEEELK 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  398 KALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQL--------DTKLPRQHFIGVLDIAGFEIF 469
Cdd:cd14907    323 EALTTKIRKVGNQVITSPLSKKECINNRDSLSKELYDRLFNWLVERLNDTImpkdekdqQLFQNKYLSIGLLDIFGFEVF 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  470 EYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTF--IDFgMDLAACIELIEK-PMGIFSILEEECMFPKATD 546
Cdd:cd14907    403 QNNSFEQLCINYTNEKLQQLYISYVFKAEEQEFKEEGLEDYLnqLSY-TDNQDVIDLLDKpPIGIFNLLDDSCKLATGTD 481
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  547 TSFKNKLYDQHlgksNNFQKPKVVKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYatfa 626
Cdd:cd14907    482 EKLLNKIKKQH----KNNSKLIFPNKINKDTFTIRHTAKEVEYNIEGFREKNKDEISQSIINCIQNSKNRIISSIF---- 553
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  627 TADADSGKKKVAKKKGSSFQ--TVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIR 704
Cdd:cd14907    554 SGEDGSQQQNQSKQKKSQKKdkFLGSKFRNQMKQLMNELMQCDVHFIRCIKPNEEKKADLFIQGYVLNQIRYLGVLESIR 633
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462555497  705 ICRKGFPNRILYGDFKQRYRVLNasaipegqfidskkacekllasididhTQYKFGHTKVFFK 767
Cdd:cd14907    634 VRKQGYPYRKSYEDFYKQYSLLK---------------------------KNVLFGKTKIFMK 669
MYSc_Myo28 cd14889
class XXVIII myosin, motor domain; These myosins are found in fish, chicken, and mollusks. The ...
102-767 8.61e-140

class XXVIII myosin, motor domain; These myosins are found in fish, chicken, and mollusks. The tail regions of these class-XXVIII myosins consist of an IQ motif, a short coiled-coil region, and an SH2 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276854  Cd Length: 659  Bit Score: 450.90  E-value: 8.61e-140
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  102 VLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFML----TDRENQSILI 177
Cdd:cd14889      3 LLEVLKVRFMQSNIYTYVGDILVAINPFKYLHIYEKEVSQKYKCEKKSSLPPHIFAVADRAYQSMLgrlaRGPKNQCIVI 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  178 TGESGAGKTVNTKRVIQYFATIAatgdlakkkdsKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFgTTG 257
Cdd:cd14889     83 SGESGAGKTESTKLLLRQIMELC-----------RGNSQLEQQILQVNPLLEAFGNAQTVMNDNSSRFGKYIQLRF-RNG 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  258 KLASADIETYLLEKSRVTFQLKAERSYHIFYQI---LSNKKPELIELLlittNPYDYPFISQGeilvASIDDAEELLATD 334
Cdd:cd14889    151 HVKGAKINEYLLEKSRVVHQDGGEENFHIFYYMfagISAEDRENYGLL----DPGKYRYLNNG----AGCKREVQYWKKK 222
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  335 -----SAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREE-QAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVG 408
Cdd:cd14889    223 ydevcNAMDMVGFTEQEEVDMFTILAGILSLGNITFEMDDDEAlKVENDSNGWLKAAAGQFGVSEEDLLKTLTCTVTFTR 302
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  409 NEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLdtkLPRQHF------IGVLDIAGFEIFEYNSLEQLCINFT 482
Cdd:cd14889    303 GEQIQRHHTKQQAEDARDSIAKVAYGRVFGWIVSKINQLL---APKDDSsvelreIGILDIFGFENFAVNRFEQACINLA 379
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  483 NEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLAACIEL-IEKPMGIFSILEEECMFPKATDTSFKNKLyDQHLGKS 561
Cdd:cd14889    380 NEQLQYFFNHHIFLMEQKEYKKEGIDWKEITY-KDNKPILDLfLNKPIGILSLLDEQSHFPQATDESFVDKL-NIHFKGN 457
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  562 NNFqkpKVVKGRAEAhFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKK 641
Cdd:cd14889    458 SYY---GKSRSKSPK-FTVNHYAGKVTYNASGFLEKNRDTIPASIRTLFINSATPLLSVLFTATRSRTGTLMPRAKLPQA 533
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  642 GSSF------QTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRIL 715
Cdd:cd14889    534 GSDNfnstrkQSVGAQFKHSLGVLMEKMFAASPHFVRCIKPNHVKVPGQLDSKYIQDQLRYNGLLETIRIRREGFSWRPS 613
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462555497  716 YGDFKQRYRVLnasaIPEGQFIDSKKACEKLLASIDIdhTQYKFGHTKVFFK 767
Cdd:cd14889    614 FAEFAERYKIL----LCEPALPGTKQSCLRILKATKL--VGWKCGKTRLFFK 659
PTZ00014 PTZ00014
myosin-A; Provisional
62-826 2.27e-138

myosin-A; Provisional


Pssm-ID: 240229 [Multi-domain]  Cd Length: 821  Bit Score: 452.56  E-value: 2.27e-138
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   62 VETEDNRTLVVKPEDVYAMNPP-KFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVV 140
Cdd:PTZ00014    71 IDPPTNSTFEVKPEHAFNANSQiDPMTYGDIGLLPHTNIPCVLDFLKHRYLKNQIYTTADPLLVAINPFKDLGNTTNDWI 150
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  141 EGYR-GKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATiAATGDlakkkdskMKGTLED 219
Cdd:PTZ00014   151 RRYRdAKDSDKLPPHVFTTARRALENLHGVKKSQTIIVSGESGAGKTEATKQIMRYFAS-SKSGN--------MDLKIQN 221
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  220 QIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELI 299
Cdd:PTZ00014   222 AIMAANPVLEAFGNAKTIRNNNSSRFGRFMQLQLGEEGGIRYGSIVAFLLEKSRVVTQEDDERSYHIFYQLLKGANDEMK 301
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  300 ELLLItTNPYDYPFISQGEILVASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAE---- 375
Cdd:PTZ00014   302 EKYKL-KSLEEYKYINPKCLDVPGIDDVKDFEEVMESFDSMGLSESQIEDIFSILSGVLLLGNVEIEGKEEGGLTDaaai 380
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  376 -PDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPR 454
Cdd:PTZ00014   381 sDESLEVFNEACELLFLDYESLKKELTVKVTYAGNQKIEGPWSKDESEMLKDSLSKAVYEKLFLWIIRNLNATIEPPGGF 460
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  455 QHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGI-----EWTfidfgmDLAACIELI-EKP 528
Cdd:PTZ00014   461 KVFIGMLDIFGFEVFKNNSLEQLFINITNEMLQKNFVDIVFERESKLYKDEGIsteelEYT------SNESVIDLLcGKG 534
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  529 MGIFSILEEECMFPKATDTSFKNKLYDQHlgKSNNFQKPKVVKGRAEahFSLIHYAGTVDYSVSGWLEKNKDPLNETVVG 608
Cdd:PTZ00014   535 KSVLSILEDQCLAPGGTDEKFVSSCNTNL--KNNPKYKPAKVDSNKN--FVIKHTIGDIQYCASGFLFKNKDVLRPELVE 610
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  609 LYQKSSNRLLAHLyatFATADADSGKKKVAKKKGSSFQtvsalfrENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHS 688
Cdd:PTZ00014   611 VVKASPNPLVRDL---FEGVEVEKGKLAKGQLIGSQFL-------NQLDSLMSLINSTEPHFIRCIKPNENKKPLDWNSS 680
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  689 LVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNAsAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKA 768
Cdd:PTZ00014   681 KVLIQLHSLSILEALQLRQLGFSYRRTFAEFLSQFKYLDL-AVSNDSSLDPKEKAEKLLERSGLPKDSYAIGKTMVFLKK 759
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462555497  769 GLLGTLEEMRDDRLAK---LITRTQAVCRGFLMRVEFQKMVQrreSIFCIQYNIRSFMNVK 826
Cdd:PTZ00014   760 DAAKELTQIQREKLAAwepLVSVLEALILKIKKKRKVRKNIK---SLVRIQAHLRRHLVIA 817
MYSc_Myo47 cd14908
class XLVII myosin, motor domain; The class XLVII myosins are comprised of Stramenopiles. Not ...
100-767 4.19e-134

class XLVII myosin, motor domain; The class XLVII myosins are comprised of Stramenopiles. Not much is known about this myosin class. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276873 [Multi-domain]  Cd Length: 682  Bit Score: 435.88  E-value: 4.19e-134
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYR--GKKRQ---EAP----PHIFSISDNAYQFMLTD- 169
Cdd:cd14908      1 PAILHSLSRRFFRGIIYTWTGPVLIAVNPFQRLPLYGKEILESYRqeGLLRSqgiESPqalgPHVFAIADRSYRQMMSEi 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  170 RENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKM-KGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKF 248
Cdd:cd14908     81 RASQSILISGESGAGKTESTKIVMLYLTTLGNGEEGAPNEGEELgKLSIMDRVLQSNPILEAFGNARTLRNDNSSRFGKF 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  249 IRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIL---SNKKPELIELLLITTN----PYDYPFISQGEIL- 320
Cdd:cd14908    161 IELGFNRAGNLLGAKVQTYLLEKVRLPFHASGERNYHIFYQLLrggDEEEHEKYEFHDGITGglqlPNEFHYTGQGGAPd 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  321 VASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQRE---EQAEPDGTEVADKTAYLMGLNSSDLL 397
Cdd:cd14908    241 LREFTDEDGLVYTLKAMRTMGWEESSIDTILDIIAGLLHLGQLEFESKEEDgaaEIAEEGNEKCLARVAKLLGVDVDKLL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  398 KALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQL--DTKLPRQHFIGVLDIAGFEIFEYNSLE 475
Cdd:cd14908    321 RALTSKIIVVRGKEITTKLTPHKAYDARDALAKTIYGALFLWVVATVNSSInwENDKDIRSSVGVLDIFGFECFAHNSFE 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  476 QLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLAACIELIE-KPMGIFSILEEECMFP-KATDTSFKNKL 553
Cdd:cd14908    401 QLCINFTNEALQQQFNQFIFKLEQKEYEKESIEWAFIEFP-DNQDCLDTIQaKKKGILTMLDDECRLGiRGSDANYASRL 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  554 YDQHLGKSNN-------FQKPKVVKGRaeAHFSLIHYAGTVDYSV-SGWLEKNKDPLNETVVGLYQKSSNrllahlyatf 625
Cdd:cd14908    480 YETYLPEKNQthsentrFEATSIQKTK--LIFAVRHFAGQVQYTVeTTFCEKNKDEIPLTADSLFESGQQ---------- 547
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  626 atadadsgkkkvakkkgssfqtvsalFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRI 705
Cdd:cd14908    548 --------------------------FKAQLHSLIEMIEDTDPHYIRCIKPNDAAKPDLVTRKRVTEQLRYGGVLEAVRV 601
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  706 CRKGFPNRILYGDFKQRYRVLnASAIPE-----------GQFIDSKKACEKLLASI---------DIDHTQYKFGHTKVF 765
Cdd:cd14908    602 ARSGYPVRLPHKDFFKRYRML-LPLIPEvvlswsmerldPQKLCVKKMCKDLVKGVlspamvsmkNIPEDTMQLGKSKVF 680

                   ..
gi 2462555497  766 FK 767
Cdd:cd14908    681 MR 682
MYSc_Myo30 cd14891
class XXX myosin, motor domain; Myosins of class XXX are composed of an amino-terminal ...
100-767 9.32e-132

class XXX myosin, motor domain; Myosins of class XXX are composed of an amino-terminal SH3-like domain, two IQ motifs, a coiled-coil region and a PX domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276856  Cd Length: 645  Bit Score: 427.92  E-value: 9.32e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRY--TSWMIYTYSGLFCVTVNPYKWLPvyNPEVvEGYRGKKRQEAPPHIFSISDNAYQFMLTDRE---NQS 174
Cdd:cd14891      1 AGILHNLEERSklDNQRPYTFMANVLIAVNPLRRLP--EPDK-SDYINTPLDPCPPHPYAIAEMAYQQMCLGSGrmqNQS 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  175 ILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKG--------TLEDQIISANPLLEAFGNAKTVRNDNSSRFG 246
Cdd:cd14891     78 IVISGESGAGKTETSKIILRFLTTRAVGGKKASGQDIEQSSkkrklsvtSLDERLMDTNPILESFGNAKTLRNHNSSRFG 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  247 KFIRIHFGTTG-KLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITtNPYDYPFISQ-GEILVASI 324
Cdd:cd14891    158 KFMKLQFTKDKfKLAGAFIETYLLEKSRLVAQPPGERNFHIFYQLLAGASAELLKELLLL-SPEDFIYLNQsGCVSDDNI 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  325 DDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREE----QAEPDGTEVADKTAYLMGLNSSDLLKAL 400
Cdd:cd14891    237 DDAANFDNVVSALDTVGIDEDLQLQIWRILAGLLHLGNIEFDEEDTSEgeaeIASESDKEALATAAELLGVDEEALEKVI 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  401 CFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFE-YNSLEQLCI 479
Cdd:cd14891    317 TQREIVTRGETFTIKRNAREAVYSRDAIAKSIYERLFLWIVQQINTSLGHDPDPLPYIGVLDIFGFESFEtKNDFEQLLI 396
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  480 NFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLAACIELI-EKPMGIFSILEEECMFPKATDTSFKNKLYDQHl 558
Cdd:cd14891    397 NYANEALQATFNQQVFIAEQELYKSEGIDVGVITWP-DNRECLDLIaSKPNGILPLLDNEARNPNPSDAKLNETLHKTH- 474
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  559 GKSNNFQKPKvvkgRAEAHFSLI--HYAGTVDYSVSGWLEKNKDplnetvvglyqkssnRLLAHLYATFATadadsgkkk 636
Cdd:cd14891    475 KRHPCFPRPH----PKDMREMFIvkHYAGTVSYTIGSFIDKNND---------------IIPEDFEDLLAS--------- 526
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  637 vakkkgssfqtvSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILY 716
Cdd:cd14891    527 ------------SAKFSDQMQELVDTLEATRCNFIRCIKPNAAMKVGVFDNRYVVDQLRCSGILQTCEVLKVGLPTRVTY 594
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462555497  717 GDFKQRYRVLNASAI------PEGQFIdskkacEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14891    595 AELVDVYKPVLPPSVtrlfaeNDRTLT------QAILWAFRVPSDAYRLGRTRVFFR 645
MYSc_Myo41 cd14902
class XLI myosin, motor domain; The class XLI myosins are comprised of Stramenopiles. Not much ...
100-723 5.60e-129

class XLI myosin, motor domain; The class XLI myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276867 [Multi-domain]  Cd Length: 716  Bit Score: 422.38  E-value: 5.60e-129
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLP---------VYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFML-TD 169
Cdd:cd14902      1 AALLQALSERFEHDQIYTSIGDILVALNPLKPLPdlysesqlnAYKASMTSTSPVSQLSELPPHVFAIGGKAFGGLLkPE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  170 RENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKgTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFI 249
Cdd:cd14902     81 RRNQSILVSGESGSGKTESTKFLMQFLTSVGRDQSSTEQEGSDAV-EIGKRILQTNPILESFGNAQTIRNDNSSRFGKFI 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  250 RIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITtNPYDYPFISQGEILVA-----SI 324
Cdd:cd14902    160 KIQFGANNEIVGAQIVSYLLEKVRLLHQSPEERSFHIFYELLEGADKTLLDLLGLQ-KGGKYELLNSYGPSFArkravAD 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  325 DDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKqkqrEEQAEPDGTEVA-------DKTAYLMGLNSSDLL 397
Cdd:cd14902    239 KYAQLYVETVRAFEDTGVGELERLDIFKILAALLHLGNVNFT----AENGQEDATAVTaasrfhlAKCAELMGVDVDKLE 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  398 KALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHF---------IGVLDIAGFEI 468
Cdd:cd14902    315 TLLSSREIKAGVEVMVLKLTPEQAKEICGSLAKAIYGRLFTWLVRRLSDEINYFDSAVSIsdedeelatIGILDIFGFES 394
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  469 FEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLAACIELIE-KPMGIFSILEEECMFPKATDT 547
Cdd:cd14902    395 LNRNGFEQLCINYANERLQAQFNEFVFVKEQQIYIAEGIDWKNISYP-SNAACLALFDdKSNGLFSLLDQECLMPKGSNQ 473
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  548 SFKNKLYDQHLGksnnfqkpkvvkgraEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFAT 627
Cdd:cd14902    474 ALSTKFYRYHGG---------------LGQFVVHHFAGRVCYNVEQFVEKNTDALPADASDILSSSSNEVVVAIGADENR 538
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  628 ADADSGKKKVAKKKGSSFQT--VSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRI 705
Cdd:cd14902    539 DSPGADNGAAGRRRYSMLRApsVSAQFKSQLDRLIVQIGRTEAHYVRCLKPNEVKKPGIFDRERMVEQMRSVGVLEAVRI 618
                          650
                   ....*....|....*...
gi 2462555497  706 CRKGFPNRILYGDFKQRY 723
Cdd:cd14902    619 ARHGYSVRLAHASFIELF 636
MYSc_Myo14 cd14876
class XIV myosin, motor domain; These myosins localize to plasma membranes of the ...
100-767 1.31e-125

class XIV myosin, motor domain; These myosins localize to plasma membranes of the intracellular parasites and may be involved in the cell invasion process. Their known functions include: transporting phagosomes to the nucleus and perturbing the developmentally regulated elimination of the macronucleus during conjugation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. C-terminal to their motor domain these myosins have a MyTH4-FERM protein domain combination. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276843  Cd Length: 649  Bit Score: 410.53  E-value: 1.31e-125
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRG-KKRQEAPPHIFSISDNAYQFMLTDRENQSILIT 178
Cdd:cd14876      1 PCVLDFLKHRYLKNQIYTTADPLLVAINPFKDLGNATDEWIRKYRDaPDLTKLPPHVFYTARRALENLHGVNKSQTIIVS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  179 GESGAGKTVNTKRVIQYFATiaatgdlakKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGK 258
Cdd:cd14876     81 GESGAGKTEATKQIMRYFAS---------AKSGNMDLRIQTAIMAANPVLEAFGNAKTIRNNNSSRFGRFMQLDVASEGG 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  259 LASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTnPYDYPFISQGEILVASIDDAEELLATDSAID 338
Cdd:cd14876    152 IRYGSVVAFLLEKSRIVTQDDNERSYHIFYQLLKGADSEMKSKYHLLG-LKEYKFLNPKCLDVPGIDDVADFEEVLESLK 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  339 ILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQ-----AEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVT 413
Cdd:cd14876    231 SMGLTEEQIDTVFSIVSGVLLLGNVKITGKTEQGVddaaaISNESLEVFKEACSLLFLDPEALKRELTVKVTKAGGQEIE 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  414 KGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHH 493
Cdd:cd14876    311 GRWTKDDAEMLKLSLAKAMYDKLFLWIIRNLNSTIEPPGGFKNFMGMLDIFGFEVFKNNSLEQLFINITNEMLQKNFIDI 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  494 MFVLEQEEYKKEGI-----EWTfidfgmDLAACIE-LIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHlgKSNNFQKP 567
Cdd:cd14876    391 VFERESKLYKDEGIptaelEYT------SNAEVIDvLCGKGKSVLSILEDQCLAPGGSDEKFVSACVSKL--KSNGKFKP 462
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  568 KVVKGRAEahFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLyatFATADADSGKKKVAKKKGSSFQT 647
Cdd:cd14876    463 AKVDSNIN--FIVVHTIGDIQYNAEGFLFKNKDVLRAELVEVVQASTNPVVKAL---FEGVVVEKGKIAKGSLIGSQFLK 537
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  648 vsalfreNLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLN 727
Cdd:cd14876    538 -------QLESLMGLINSTEPHFIRCIKPNETKKPLEWNSSKVLIQLHALSILEALQLRQLGYSYRRPFEEFLYQFKFLD 610
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|
gi 2462555497  728 AsAIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14876    611 L-GIANDKSLDPKVAALKLLESSGLSEDEYAIGKTMVFLK 649
MYSc_Myo34 cd14895
class XXXIV myosin, motor domain; Class XXXIV myosins are composed of an IQ motif, a short ...
100-767 3.66e-124

class XXXIV myosin, motor domain; Class XXXIV myosins are composed of an IQ motif, a short coiled-coil region, 5 tandem ANK repeats, and a carboxy-terminal FYVE domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276860 [Multi-domain]  Cd Length: 704  Bit Score: 408.57  E-value: 3.66e-124
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNpevVEGYRGK--KRQEAPPHIFSISDNAYQFMLT-------D 169
Cdd:cd14895      1 PAFVDYLAQRYGVDQVYCRSGAVLIAVNPFKHIPgLYD---LHKYREEmpGWTALPPHVFSIAEGAYRSLRRrlhepgaS 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  170 RENQSILITGESGAGKTVNTKRVIQYFATIAATGDlAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFI 249
Cdd:cd14895     78 KKNQTILVSGESGAGKTETTKFIMNYLAESSKHTT-ATSSSKRRRAISGSELLSANPILESFGNARTLRNDNSSRFGKFV 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  250 RIHFG-----TTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPE-LIELLLITTNPYDYPFISQGEILVAS 323
Cdd:cd14895    157 RMFFEgheldTSLRMIGTSVETYLLEKVRVVHQNDGERNFHVFYELLAGAADDmKLELQLELLSAQEFQYISGGQCYQRN 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  324 --IDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVA------------------D 383
Cdd:cd14895    237 dgVRDDKQFQLVLQSMKVLGFTDVEQAAIWKILSALLHLGNVLFVASSEDEGEEDNGAASApcrlasaspssltvqqhlD 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  384 KTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQ---QLDTKLPRQH---- 456
Cdd:cd14895    317 IVSKLFAVDQDELVSALTTRKISVGGETFHANLSLAQCGDARDAMARSLYAFLFQFLVSKVNSaspQRQFALNPNKaank 396
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  457 ----FIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLAACIELIE-KPMGI 531
Cdd:cd14895    397 dttpCIAVLDIFGFEEFEVNQFEQFCINYANEKLQYQFIQDILLTEQQAHIEEGIKWNAVDYE-DNSVCLEMLEqRPSGI 475
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  532 FSILEEECMFPKATDTSFKNKLYdQHLGKSNNFQKPKvvKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQ 611
Cdd:cd14895    476 FSLLDEECVVPKGSDAGFARKLY-QRLQEHSNFSASR--TDQADVAFQIHHYAGAVRYQAEGFCEKNKDQPNAELFSVLG 552
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  612 KSSNRLLAHLYATF-ATADADSGKKKVAKKKGSSFQT---VSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEH 687
Cdd:cd14895    553 KTSDAHLRELFEFFkASESAELSLGQPKLRRRSSVLSsvgIGSQFKQQLASLLDVVQQTQTHYIRCIKPNDESASDQFDM 632
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  688 SLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAIPegqfidSKKACEKLLASIDIDHTQykFGHTKVFFK 767
Cdd:cd14895    633 AKVSSQLRYGGVLKAVEIMRQSYPVRMKHADFVKQYRLLVAAKNA------SDATASALIETLKVDHAE--LGKTRVFLR 704
MYSc_Myo35 cd14896
class XXXV myosin, motor domain; This class of metazoan myosins contains 2 IQ motifs, 2 MyTH4 ...
100-767 8.86e-120

class XXXV myosin, motor domain; This class of metazoan myosins contains 2 IQ motifs, 2 MyTH4 domains, a single FERM domain, and an SH3 domain. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276861 [Multi-domain]  Cd Length: 644  Bit Score: 393.76  E-value: 8.86e-120
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14896      1 SSVLLCLKKRFHLGRIYTFGGPILLSLNPHRSLPLFSEEVLASYHPRKALNTTPHIFAIAASAYRLSQSTGQDQCILLSG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATiaatgdLAKKKDSKMKGTLEDQIisanPLLEAFGNAKTVRNDNSSRFGKFIRIHFgTTGKL 259
Cdd:cd14896     81 HSGSGKTEAAKKIVQFLSS------LYQDQTEDRLRQPEDVL----PILESFGHAKTILNANASRFGQVLRLHL-QHGVI 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  260 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLItTNPYDYPFISQGEIL-VASIDDAEELLATDSAID 338
Cdd:cd14896    150 VGASVSHYLLETSRVVFQAQAERSFHVFYELLAGLDPEEREQLSL-QGPETYYYLNQGGACrLQGKEDAQDFEGLLKALQ 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  339 ILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQ---AEPDGTEVadKTAYLMGLNSSDLLKALCFPRVKVGN-EYVTK 414
Cdd:cd14896    229 GLGLCAEELTAIWAVLAAILQLGNICFSSSERESQevaAVSSWAEI--HTAARLLQVPPERLEGAVTHRVTETPyGRVSR 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  415 GQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHF--IGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNH 492
Cdd:cd14896    307 PLPVEGAIDARDALAKTLYSRLFTWLLKRINAWLAPPGEAESDatIGVVDAYGFEALRVNGLEQLCINLASERLQLFSSQ 386
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  493 HMFVLEQEEYKKEGIEWTFIDfGMDLAACIELI-EKPMGIFSILEEECMFPKATDTSFKNKLYDQHlGKSNNFQKPKVvk 571
Cdd:cd14896    387 TLLAQEEEECQRELLPWVPIP-QPPRESCLDLLvDQPHSLLSILDDQTWLSQATDHTFLQKCHYHH-GDHPSYAKPQL-- 462
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  572 grAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLyatFATADADSGKKKVAKKKGSSFQtvsal 651
Cdd:cd14896    463 --PLPVFTVRHYAGTVTYQVHKFLNRNRDQLDPAVVEMLAQSQLQLVGSL---FQEAEPQYGLGQGKPTLASRFQ----- 532
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  652 frENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASAI 731
Cdd:cd14896    533 --QSLGDLTARLGRSHVYFIHCLNPNPGKLPGLFDVGHVTEQLRQAGILEAIGTRSEGFPVRVPFQAFLARFGALGSERQ 610
                          650       660       670
                   ....*....|....*....|....*....|....*..
gi 2462555497  732 PEgqfIDSKKACEKLLASIDIDHTQ-YKFGHTKVFFK 767
Cdd:cd14896    611 EA---LSDRERCGAILSQVLGAESPlYHLGATKVLLK 644
MYSc_Myo19 cd14880
class XIX myosin, motor domain; Monomeric myosin-XIX (Myo19) functions as an actin-based motor ...
102-726 8.72e-114

class XIX myosin, motor domain; Monomeric myosin-XIX (Myo19) functions as an actin-based motor for mitochondrial movement in vertebrate cells. It contains a variable number of IQ domains. Human myo19 contains a motor domain, three IQ motifs, and a short tail. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276846 [Multi-domain]  Cd Length: 658  Bit Score: 377.27  E-value: 8.72e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  102 VLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNPEVVEGYRGKKR-QEAPPHIFSISDNAYQFMLTDRE--NQSILI 177
Cdd:cd14880      3 VLRCLQARYTADTFYTNAGCTLVALNPFKPVPqLYSPELMREYHAAPQpQKLKPHIFTVGEQTYRNVKSLIEpvNQSIVV 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  178 TGESGAGKTVNTKRVIQYFATIAATgdLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 257
Cdd:cd14880     83 SGESGAGKTWTSRCLMKFYAVVAAS--PTSWESHKIAERIEQRILNSNPVMEAFGNACTLRNNNSSRFGKFIQLQLNRAQ 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  258 KLASADIETYLLEKSRVTFQLKAERSYHIFYQILSN-KKPELIELLLITTNPYDYpfisqgeiLVASIDDAEE--LLATD 334
Cdd:cd14880    161 QMTGAAVQTYLLEKTRVACQAPSERNFHIFYQICKGaSADERLQWHLPEGAAFSW--------LPNPERNLEEdcFEVTR 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  335 SAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQA---EPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEY 411
Cdd:cd14880    233 EAMLHLGIDTPTQNNIFKVLAGLLHLGNIQFADSEDEAQPcqpMDDTKESVRTSALLLKLPEDHLLETLQIRTIRAGKQQ 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  412 VT--KGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPR-QHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQ 488
Cdd:cd14880    313 QVfkKPCSRAECDTRRDCLAKLIYARLFDWLVSVINSSICADTDSwTTFIGLLDVYGFESFPENSLEQLCINYANEKLQQ 392
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  489 FFNHHMFVLEQEEYKKEGIEWTFIDFgMDLAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKP 567
Cdd:cd14880    393 HFVAHYLRAQQEEYAVEGLEWSFINY-QDNQTCLDLIEgSPISICSLINEECRLNRPSSAAQLQTRIESALAGNPCLGHN 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  568 KVVKgraEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLyatFATADADSGKKKVAKKKGSSFQT 647
Cdd:cd14880    472 KLSR---EPSFIVVHYAGPVRYHTAGLVEKNKDPVPPELTRLLQQSQDPLLQKL---FPANPEEKTQEEPSGQSRAPVLT 545
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462555497  648 VSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVL 726
Cdd:cd14880    546 VVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQCQAQTFLQEEVLSQLEACGLVETIHISAAGFPIRVSHQNFVERYKLL 624
MYSc_Myo38 cd14899
class XXXVIII myosin; The class XXXVIII myosins are comprised of Stramenopiles. Not much is ...
101-724 9.81e-114

class XXXVIII myosin; The class XXXVIII myosins are comprised of Stramenopiles. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276864 [Multi-domain]  Cd Length: 717  Bit Score: 379.05  E-value: 9.81e-114
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNPEVVEGY----------RGKKRQEAPPHIFSISDNAYQFMLTD 169
Cdd:cd14899      2 SILNALRLRYERHAIYTHIGDILISINPFQDLPqLYGDEILRGYaydhnsqfgdRVTSTDPREPHLFAVARAAYIDIVQN 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  170 RENQSILITGESGAGKTVNTKRVIQYFA-------TIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNS 242
Cdd:cd14899     82 GRSQSILISGESGAGKTEATKIIMTYFAvhcgtgnNNLTNSESISPPASPSRTTIEEQVLQSNPILEAFGNARTVRNDNS 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  243 SRFGKFIRIHF-GTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNK----KPELIELLLITTNPYDYPFISQG 317
Cdd:cd14899    162 SRFGKFIELRFrDERRRLAGARIRTYLLEKIRVIKQAPHERNFHIFYELLSADnncvSKEQKQVLALSGGPQSFRLLNQS 241
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  318 --EILVASIDDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQ--KQREEQAEPDGTEVA----------D 383
Cdd:cd14899    242 lcSKRRDGVKDGVQFRATKRAMQQLGMSEGEIGGVLEIVAAVLHMGNVDFEQipHKGDDTVFADEARVMssttgafdhfT 321
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  384 KTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQL--------------- 448
Cdd:cd14899    322 KAAELLGVSTEALDHALTKRWLHASNETLVVGVDVAHARNTRNALTMECYRLLFEWLVARVNNKLqrqasapwgadesdv 401
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  449 DTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDlAACIELIE-K 527
Cdd:cd14899    402 DDEEDATDFIGLLDIFGFEDMAENSFEQLCINYANEALQHQFNQYIFEEEQRLYRDEGIRWSFVDFPNN-RACLELFEhR 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  528 PMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVV 607
Cdd:cd14899    481 PIGIFSLTDQECVFPQGTDRALVAKYYLEFEKKNSHPHFRSAPLIQRTTQFVVAHYAGCVTYTIDGFLAKNKDSFCESAA 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  608 GLYQKSSNRLLAHLYATFATADAD--------SGKKKVAKKKGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNET 679
Cdd:cd14899    561 QLLAGSSNPLIQALAAGSNDEDANgdseldgfGGRTRRRAKSAIAAVSVGTQFKIQLNELLSTVRATTPRYVRCIKPNDS 640
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*
gi 2462555497  680 KTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYR 724
Cdd:cd14899    641 HVGSLFQSTRVVEQLRSGGVLEAVRVARAGFPVRLTHKQFLGRYR 685
MYSc_Myo45 cd14906
class XLV myosin, motor domain; The class XLVI myosins are comprised of slime molds ...
102-729 3.46e-113

class XLV myosin, motor domain; The class XLVI myosins are comprised of slime molds Dictyostelium and Polysphondylium. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276871 [Multi-domain]  Cd Length: 715  Bit Score: 377.40  E-value: 3.46e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  102 VLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNPEVVEGYRGKKR-QEAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14906      3 ILNNLGKRYKSDSIYTYIGNVLISINPYKDISsIYSNLILNEYKDINQnKSPIPHIYAVALRAYQSMVSEKKNQSIIISG 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHF-GTTGK 258
Cdd:cd14906     83 ESGSGKTEASKTILQYLINTSSSNQQQNNNNNNNNNSIEKDILTSNPILEAFGNSRTTKNHNSSRFGKFLKIEFrSSDGK 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  259 LASADIETYLLEKSRVTFQL-KAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILVASI------------- 324
Cdd:cd14906    163 IDGASIETYLLEKSRISHRPdNINLSYHIFYYLVYGASKDERSKWGLNNDPSKYRYLDARDDVISSFksqssnknsnhnn 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  325 --DDAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQ---REEQAEPDGTEVADKTAYLMGLNSSDLLKA 399
Cdd:cd14906    243 ktESIESFQLLKQSMESMSINKEQCDAIFLSLAAILHLGNIEFEEDSdfsKYAYQKDKVTASLESVSKLLGYIESVFKQA 322
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  400 LCFPRVKVGNE--YVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQH-----------FIGVLDIAGF 466
Cdd:cd14906    323 LLNRNLKAGGRgsVYCRPMEVAQSEQTRDALSKSLYVRLFKYIVEKINRKFNQNTQSNDlaggsnkknnlFIGVLDIFGF 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  467 EIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLAACIELIE-KPMGIFSILEEECMFPKAT 545
Cdd:cd14906    403 ENLSSNSLEQLLINFTNEKLQQQFNLNVFENEQKEYLSEGIPWSNSNF-IDNKECIELIEkKSDGILSLLDDECIMPKGS 481
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  546 DTSFKNKlYDQHLGKSNNFQKPKVVKGRaeahFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATF 625
Cdd:cd14906    482 EQSLLEK-YNKQYHNTNQYYQRTLAKGT----LGIKHFAGDVTYQTDGWLEKNRDSLYSDVEDLLLASSNFLKKSLFQQQ 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  626 ATADADSGKKKvakkkgSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRI 705
Cdd:cd14906    557 ITSTTNTTKKQ------TQSNTVSGQFLEQLNQLIQTINSTSVHYIRCIKPNQTMDCNNFNNVHVLSQLRNVGVLNTIKV 630
                          650       660
                   ....*....|....*....|....
gi 2462555497  706 CRKGFPNRILYGDFKQRYRVLNAS 729
Cdd:cd14906    631 RKMGYSYRRDFNQFFSRYKCIVDM 654
MYSc_Myo25 cd14886
class XXV myosin, motor domain; These myosins are MyTH-FERM myosins that play a role in cell ...
106-767 1.04e-109

class XXV myosin, motor domain; These myosins are MyTH-FERM myosins that play a role in cell adhesion and filopodia formation. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276851  Cd Length: 650  Bit Score: 365.36  E-value: 1.04e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  106 LKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNPEVVEGYRGKKRQ-----EAPPHIFSISDNAYQFMLTDRENQSILITG 179
Cdd:cd14886      7 LRDRFAKDKIYTYAGKLLVALNPFKQIRnLYGTEVIGRYRQADTSrgfpsDLPPHSYAVAQSALNGLISDGISQSCIVSG 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYFATIAATGDlakkkdskmkGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 259
Cdd:cd14886     87 ESGAGKTETAKQLMNFFAYGHSTSS----------TDVQSLILGSNPLLESFGNAKTLRNNNSSRFGKFIKLLVGPDGGL 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  260 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYdYPFISQGEILVA-SIDDAEELLATDSAID 338
Cdd:cd14886    157 KGGKITSYMLELSRIEFQSTNERNYHIFYQCIKGLSPEEKKSLGFKSLES-YNFLNASKCYDApGIDDQKEFAPVRSQLE 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  339 ILgFTPEEKSGLYKLTGAVMHYGNMKFKQKQR---EEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKG 415
Cdd:cd14886    236 KL-FSKNEIDSFYKCISGILLAGNIEFSEEGDmgvINAAKISNDEDFGKMCELLGIESSKAAQAIITKVVVINNETIISP 314
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  416 QTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMF 495
Cdd:cd14886    315 VTQAQAEVNIRAVAKDLYGALFELCVDTLNEIIQFDADARPWIGILDIYGFEFFERNTYEQLLINYANERLQQYFINQVF 394
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  496 VLEQEEYKKEGIEWTFIDFgMDLAACIELIEKP-MGIFSILEEECMFPKATDTSFKNKLyDQHLgKSNNFQKPKvvkgRA 574
Cdd:cd14886    395 KSEIQEYEIEGIDHSMITF-TDNSNVLAVFDKPnLSIFSFLEEQCLIQTGSSEKFTSSC-KSKI-KNNSFIPGK----GS 467
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  575 EAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHlyaTFATADADSGKKKVakkkgssfQTVSALFRE 654
Cdd:cd14886    468 QCNFTIVHTAATVTYNTEEFVDKNKHKLSVDILELLMGSTNPIVNK---AFSDIPNEDGNMKG--------KFLGSTFQL 536
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  655 NLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVL---NASAI 731
Cdd:cd14886    537 SIDQLMKTLSATKSHFIRCIKTNQDKVPNKYETKSVYNQLISLSIFESIQTIHRGFAYNDTFEEFFHRNKILishNSSSQ 616
                          650       660       670
                   ....*....|....*....|....*....|....*.
gi 2462555497  732 PEGQfiDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14886    617 NAGE--DLVEAVKSILENLGIPCSDYRIGKTKVFLR 650
MYSc_Myo13 cd14875
class XIII myosin, motor domain; These myosins have an N-terminal motor domain, a light-chain ...
102-767 8.79e-105

class XIII myosin, motor domain; These myosins have an N-terminal motor domain, a light-chain binding domain, and a C-terminal GPA/Q-rich domain. There is little known about the function of this myosin class. Two of the earliest members identified in this class are green alga Acetabularia cliftonii, Aclmyo1 and Aclmyo2. They are striking with their short tail of Aclmyo1 of 18 residues and the maximum of 7 IQ motifs in Aclmyo2. It is thought that these myosins are involved in organelle transport and tip growth. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276842 [Multi-domain]  Cd Length: 664  Bit Score: 351.42  E-value: 8.79e-105
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  102 VLYNLKDRYTSWMI-YTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEA-PPHIFSISDNAY-QFMLTDRENQSILIT 178
Cdd:cd14875      3 LLHCIKERFEKLHQqYSLMGEMVLSVNPFRLMPFNSEEERKKYLALPDPRLlPPHIWQVAHKAFnAIFVQGLGNQSVVIS 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  179 GESGAGKTVNTKRVIQYFATIAATgdlakKKDSKMKGTLEDQIIS----ANPLLEAFGNAKTVRNDNSSRFGKFIRIHF- 253
Cdd:cd14875     83 GESGSGKTENAKMLIAYLGQLSYM-----HSSNTSQRSIADKIDEnlkwSNPVMESFGNARTVRNDNSSRFGKYIKLYFd 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  254 GTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGEILV------ASIDDA 327
Cdd:cd14875    158 PTSGVMVGGQTVTYLLEKSRIIMQSPGERNYHIFYEMLAGLSPEEKKELGGLKTAQDYKCLNGGNTFVrrgvdgKTLDDA 237
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  328 EELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQReeqaepDGTEVADKTAYLMGLNSSDLLKAL---CFpR 404
Cdd:cd14875    238 HEFQNVRHALSMIGVELETQNSIFRVLASILHLMEVEFESDQN------DKAQIADETPFLTACRLLQLDPAKlreCF-L 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  405 VKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKL--PRQHFIGVLDIAGFEIFEYNSLEQLCINFT 482
Cdd:cd14875    311 VKSKTSLVTILANKTEAEGFRNAFCKAIYVGLFDRLVEFVNASITPQGdcSGCKYIGLLDIFGFENFTRNSFEQLCINYA 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  483 NEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGmDLAACIELIE-KPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKS 561
Cdd:cd14875    391 NESLQNHYNKYTFINDEEECRREGIQIPKIEFP-DNSECVNMFDqKRTGIFSMLDEECNFKGGTTERFTTNLWDQWANKS 469
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  562 NNFQKPkvvKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSgkkkvakkk 641
Cdd:cd14875    470 PYFVLP---KSTIPNQFGVNHYAAFVNYNTDEWLEKNTDALKEDMYECVSNSTDEFIRTLLSTEKGLARRK--------- 537
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  642 gssfQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDF-K 720
Cdd:cd14875    538 ----QTVAIRFQRQLTDLRTELESTETQFIRCIKPNMEASPSFLDNLLVGSQLESAGVLQTIALKRQGYPVRRPIEQFcR 613
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462555497  721 QRYRVLNASAIPEGQFIDSKKACEKLLAS----IDIDHTQYKFGHTKVFFK 767
Cdd:cd14875    614 YFYLIMPRSTASLFKQEKYSEAAKDFLAYyqrlYGWAKPNYAVGKTKVFLR 664
MYSc_Myo18 cd01386
class XVIII myosin, motor domain; Many members of this class contain a N-terminal PDZ domain ...
102-767 5.37e-103

class XVIII myosin, motor domain; Many members of this class contain a N-terminal PDZ domain which is commonly found in proteins establishing molecular complexes. The motor domain itself does not exhibit ATPase activity, suggesting that it functions as an actin tether protein. It also has two IQ domains that probably bind light chains or related calmodulins and a C-terminal tail with two sections of coiled-coil domains, which are thought to mediate homodimerization. The function of these myosins are largely unknown. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276837 [Multi-domain]  Cd Length: 689  Bit Score: 346.99  E-value: 5.37e-103
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  102 VLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGES 181
Cdd:cd01386      3 VLHTLRQRYGANLIHTYAGPSLIVINPRHPLAVYSEKVAKMFKGCRREDMPPHIYASAQSAYRAMLMSRRDQSIVLLGRS 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  182 GAGKTVNTKRVIQYFATIAATGDLAKKKdskmkgtleDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLAS 261
Cdd:cd01386     83 GSGKTTNCRHILEYLVTAAGSVGGVLSV---------EKLNAALTVLEAFGNVRTALNGNATRFSQLFSLDFDQAGQLAS 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  262 ADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELI-ELLL--ITTNPYDY--PFISQGEilvaSIDDAEELLATDSA 336
Cdd:cd01386    154 ASIQTLLLERSRVARRPEGESNFNVFYYLLAGADAALRtELHLnqLAESNSFGivPLQKPED----KQKAAAAFSKLQAA 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  337 IDILGFTPEEKSGLYKLTGAVMHYGN---MKFKQKQREEQAEPdgtEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVT 413
Cdd:cd01386    230 MKTLGISEEEQRAIWSILAAIYHLGAagaTKAASAGRKQFARP---EWAQRAAYLLGCTLEELSSAIFKHHLSGGPQQST 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  414 KGQTVDQVHH------------AVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYN------SLE 475
Cdd:cd01386    307 TSSGQESPARsssggpkltgveALEGFAAGLYSELFAAVVSLINRSLSSSHHSTSSITIVDTPGFQNPAHSgsqrgaTFE 386
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  476 QLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEK---------------PMGIFSILEEECM 540
Cdd:cd01386    387 DLCHNYAQERLQLLFHERTFVAPLERYKQENVEVDFDLPELSPGALVALIDQapqqalvrsdlrdedRRGLLWLLDEEAL 466
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  541 FPKATDTSFKNKLYdQHLGKSNNFQKPKVVKgRAEA--HFSLIHYAGT--VDYSVSGWLEKNK-DPLNETVVGLYQkSSN 615
Cdd:cd01386    467 YPGSSDDTFLERLF-SHYGDKEGGKGHSLLR-RSEGplQFVLGHLLGTnpVEYDVSGWLKAAKeNPSAQNATQLLQ-ESQ 543
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  616 RLLAHLYATFATADAdsgkkkvakkkgsSFQtvsalfrenLNKLMSNLRTTHPHFVRCIIPN------ETKTPGA----- 684
Cdd:cd01386    544 KETAAVKRKSPCLQI-------------KFQ---------VDALIDTLRRTGLHFVHCLLPQhnagkdERSTSSPaagde 601
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  685 -MEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVL----NASAIPEGQFIDSKKACEKLLASIDIDHTQYKF 759
Cdd:cd01386    602 lLDVPLLRSQLRGSQLLDALRLYRQGFPDHMPLGEFRRRFQVLapplTKKLGLNSEVADERKAVEELLEELDLEKSSYRI 681

                   ....*...
gi 2462555497  760 GHTKVFFK 767
Cdd:cd01386    682 GLSQVFFR 689
MYSc_Myo16 cd14878
class XVI myosin, motor domain; These XVI type myosins are also known as Neuronal ...
101-767 5.19e-95

class XVI myosin, motor domain; These XVI type myosins are also known as Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3/NYAP3. Myo16 is thought to play a regulatory role in cell cycle progression and has been recently implicated in Schizophrenia. Class XVI myosins are characterized by an N-terminal ankyrin repeat domain and some with chitin synthase domains that arose independently from the ones in the class XVII fungal myosins. They bind protein phosphatase 1 catalytic subunits 1alpha/PPP1CA and 1gamma/PPP1CC. Human Myo16 interacts with ACOT9, ARHGAP26 and PIK3R2 and with components of the WAVE1 complex, CYFIP1 and NCKAP1. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276844 [Multi-domain]  Cd Length: 656  Bit Score: 322.92  E-value: 5.19e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYR---GKKRQEAPPHIFSISDNAYQFMLTDRENQSILI 177
Cdd:cd14878      2 SLLYEIQKRFGNNQIYTFIGDILLLVNPYKELPIYSTMVSQLYLsssGQLCSSLPPHLFSCAERAFHQLFQERRPQCFIL 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  178 TGESGAGKTVNTKRVIQYFATiaatgdlakkKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTG 257
Cdd:cd14878     82 SGERGSGKTEASKQIMKHLTC----------RASSSRTTFDSRFKHVNCILEAFGHAKTTLNDLSSCFIKYFELQFCERK 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  258 K-LASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELiELLLITTNPYDYPFISQGE----ILVASIDDAEELLA 332
Cdd:cd14878    152 KhLTGARIYTYMLEKSRLVSQPPGQSNFLIFYLLMDGLSAEE-KYGLHLNNLCAHRYLNQTMredvSTAERSLNREKLAV 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  333 TDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYV 412
Cdd:cd14878    231 LKQALNVVGFSSLEVENLFVILSAILHLGDIRFTALTEADSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDMI 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  413 TKGQTVDQVHHAVNALSKSVYEKLFLWMVTRIN----QQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQ 488
Cdd:cd14878    311 IRRHTIQIAEFYRDLLAKSLYSRLFSFLVNTVNcclqSQDEQKSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHH 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  489 FFNHHMFVLEQEEYKKEGIEW-TFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKP 567
Cdd:cd14878    391 YINEVLFLQEQTECVQEGVTMeTAYSPGNQTGVLDFFFQKPSGFLSLLDEESQMIWSVEPNLPKKLQSLLESSNTNAVYS 470
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  568 KVVKGRAE-------AHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYAtfatadadsgkkkvakk 640
Cdd:cd14878    471 PMKDGNGNvalkdqgTAFTVMHYAGRVMYEIVGAIEKNKDSLSQNLLFVMKTSENVVINHLFQ----------------- 533
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  641 kgSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFK 720
Cdd:cd14878    534 --SKLVTIASQLRKSLADIIGKLQKCTPHFIHCIKPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDFL 611
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|....*..
gi 2462555497  721 QRYRVLNASAIPEGQFIDSKKACEKLLASIDIDHTQykFGHTKVFFK 767
Cdd:cd14878    612 SRYKPLADTLLGEKKKQSAEERCRLVLQQCKLQGWQ--MGVRKVFLK 656
MYSc_Myo24A cd14937
class XXIV A myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a ...
102-767 1.89e-92

class XXIV A myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a coiled-coil region in their C-terminal tail. The function of the class XXIV myosins remain elusive. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276897  Cd Length: 637  Bit Score: 314.65  E-value: 1.89e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  102 VLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEvvegYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGES 181
Cdd:cd14937      3 VLNMLALRYKKNYIYTIAEPMLISINPYQVIDVDINE----YKNKNTNELPPHVYSYAKDAMTDFINTKTNQSIIISGES 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  182 GAGKTVNTKRVIQYFATiaatgdlAKKKDSKMKGTLEDqiisANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLAS 261
Cdd:cd14937     79 GSGKTEASKLVIKYYLS-------GVKEDNEISNTLWD----SNFILEAFGNAKTLKNNNSSRYGKYIKIELDEYQNIVS 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  262 ADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPyDYPFISQGEILVASIDDAEELLATDSAIDILG 341
Cdd:cd14937    148 SSIEIFLLENIRVVSQEEEERGYHIFYQIFNGMSQELKNKYKIRSEN-EYKYIVNKNVVIPEIDDAKDFGNLMISFDKMN 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  342 FTpEEKSGLYKLTGAVMHYGNMKFKQ-----KQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQ 416
Cdd:cd14937    227 MH-DMKDDLFLTLSGLLLLGNVEYQEiekggKTNCSELDKNNLELVNEISNLLGINYENLKDCLVFTEKTIANQKIEIPL 305
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  417 TVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFV 496
Cdd:cd14937    306 SVEESVSICKSISKDLYNKIFSYITKRINNFLNNNKELNNYIGILDIFGFEIFSKNSLEQLLINIANEEIHSIYLYIVYE 385
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  497 LEQEEYKKEGIEWTFIDFGMDlAACIELIEKPMGIFSILEEECMFPKATDTSfknkLYDQHLGKSNNFQKPKVVKGRAEA 576
Cdd:cd14937    386 KETELYKAEDILIESVKYTTN-ESIIDLLRGKTSIISILEDSCLGPVKNDES----IVSVYTNKFSKHEKYASTKKDINK 460
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  577 HFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKkkvakkkgssfQTVSALFRENL 656
Cdd:cd14937    461 NFVIKHTVSDVTYTITNFISKNKDILPSNIVRLLKVSNNKLVRSLYEDVEVSESLGRK-----------NLITFKYLKNL 529
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  657 NKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRIcRKGFPNRILYGDFKQRYRVLNASAIPEGQF 736
Cdd:cd14937    530 NNIISYLKSTNIYFIKCIKPNENKEKNNFNQKKVFPQLFSLSIIETLNI-SFFFQYKYTFDVFLSYFEYLDYSTSKDSSL 608
                          650       660       670
                   ....*....|....*....|....*....|.
gi 2462555497  737 IDSKKACEKLLASIDIDhtQYKFGHTKVFFK 767
Cdd:cd14937    609 TDKEKVSMILQNTVDPD--LYKVGKTMVFLK 637
MYSc_Myo37 cd14898
class XXXVII myosin, motor domain; The class XXXVIII myosins are comprised of fungi. Not much ...
101-730 1.77e-91

class XXXVII myosin, motor domain; The class XXXVIII myosins are comprised of fungi. Not much is known about this myosin class. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276863  Cd Length: 578  Bit Score: 309.91  E-value: 1.77e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYkwlpvynpEVVEGYRGKKRQE-----APPHIFSISDNAYQFMLTdRENQSI 175
Cdd:cd14898      2 ATLEILEKRYASGKIYTKSGLVFLALNPY--------ETIYGAGAMKAYLknyshVEPHVYDVAEASVQDLLV-HGNQTI 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  176 LITGESGAGKTVNTKRVIQYFAtiaatgdlakkKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFgt 255
Cdd:cd14898     73 VISGESGSGKTENAKLVIKYLV-----------ERTASTTSIEKLITAANLILEAFGNAKTQLNDNSSRFGKRIKLKF-- 139
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  256 TGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKpelielLLITTNPYDYPFISQGEilVASIDDAEELLATDS 335
Cdd:cd14898    140 DGKITGAKFETYLLEKSRVTHHEKGERNFHIFYQFCASKR------LNIKNDFIDTSSTAGNK--ESIVQLSEKYKMTCS 211
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  336 AIDILGFTPEEKsgLYKLTGAVMHYGNMKFKQkqrEEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKG 415
Cdd:cd14898    212 AMKSLGIANFKS--IEDCLLGILYLGSIQFVN---DGILKLQRNESFTEFCKLHNIQEEDFEESLVKFSIQVKGETIEVF 286
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  416 QTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKlpRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMF 495
Cdd:cd14898    287 NTLKQARTIRNSMARLLYSNVFNYITASINNCLEGS--GERSISVLDIFGFEIFESNGLDQLCINWTNEKIQNDFIKKMF 364
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  496 VLEQEEYKKEGIEWTFIDFgMDLAACIELIEKPMGIFSILEEECMFPKAT--DTSFKNKLYDQHLGKSNNFQKPKVVkgr 573
Cdd:cd14898    365 RAKQGMYKEEGIEWPDVEF-FDNNQCIRDFEKPCGLMDLISEESFNAWGNvkNLLVKIKKYLNGFINTKARDKIKVS--- 440
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  574 aeahfsliHYAGTVDYSVSGWLEKNKDPLNETVVGlyqkssNRLLahlyatfatadADSGkkkvakkkgsSFQTVSALFR 653
Cdd:cd14898    441 --------HYAGDVEYDLRDFLDKNREKGQLLIFK------NLLI-----------NDEG----------SKEDLVKYFK 485
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462555497  654 ENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASA 730
Cdd:cd14898    486 DSMNKLLNSINETQAKYIKCIRPNEECRPWCFDRDLVSKQLAECGILETIRLSKQCFPQEIPKDRFEERYRILGITL 562
MYSc_Myo26 cd14887
class XXVI myosin, motor domain; These MyTH-FERM myosins are thought to be related to the ...
100-767 2.00e-89

class XXVI myosin, motor domain; These MyTH-FERM myosins are thought to be related to the other myosins that have a MyTH4 domain such as class III, VII, IX, X , XV, XVI, XVII, XX, XXII, XXV, and XXXIV. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276852  Cd Length: 725  Bit Score: 308.89  E-value: 2.00e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTS--------WMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRE 171
Cdd:cd14887      1 PNLLENLYQRYNKayinkenrNCIYTYTGTLLIAVNPYRFFNLYDRQWISRFDTEANSRLVPHPFGLAEFAYCRLVRDRR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  172 NQSILITGESGAGKTVNTKRVIQYfatIAATGDLAKKKDSKmkgTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRI 251
Cdd:cd14887     81 SQSILISGESGAGKTETSKHVLTY---LAAVSDRRHGADSQ---GLEARLLQSGPVLEAFGNAHTVLNANSSRFGKMLLL 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  252 HFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITtnpYDYPFISQGEILVAsiddaeell 331
Cdd:cd14887    155 HFTGRGKLTRASVATYLLANERVVRIPSDEFSFHIFYALCNAAVAAATQKSSAG---EGDPESTDLRRITA--------- 222
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  332 atdsAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGT--------EVADK---TAYLMGLNS------- 393
Cdd:cd14887    223 ----AMKTVGIGGGEQADIFKLLAAILHLGNVEFTTDQEPETSKKRKLtsvsvgceETAADrshSSEVKCLSSglkvtea 298
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  394 -----SDLLKALCFPRVKVGNEYV------------TKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQL-------- 448
Cdd:cd14887    299 srkhlKTVARLLGLPPGVEGEEMLrlalvsrsvretRSFFDLDGAAAARDAACKNLYSRAFDAVVARINAGLqrsakpse 378
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  449 -----DTKLPRQ-HFIGVLDIAGFEIFE---YNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFI----DFG 515
Cdd:cd14887    379 sdsdeDTPSTTGtQTIGILDLFGFEDLRnhsKNRLEQLCINYANERLHCFLLEQLILNEHMLYTQEGVFQNQDcsafPFS 458
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  516 MDLAAC--------IELIEKP--------------MGIFSILEEE-CMFPKATDTSFKNKLYDQHLGK----SNNFQKPK 568
Cdd:cd14887    459 FPLASTltsspsstSPFSPTPsfrsssafatspslPSSLSSLSSSlSSSPPVWEGRDNSDLFYEKLNKniinSAKYKNIT 538
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  569 VVKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNrllahlYATFATADADSGKKKVAkkkgSSFQTV 648
Cdd:cd14887    539 PALSRENLEFTVSHFACDVTYDARDFCRANREATSDELERLFLACST------YTRLVGSKKNSGVRAIS----SRRSTL 608
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  649 SALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNA 728
Cdd:cd14887    609 SAQFASQLQQVLKALQETSCHFIRCVKPNRVQEAGIFEDAYVHRQLRCSGMSDLLRVMADGFPCRLPYVELWRRYETKLP 688
                          730       740       750
                   ....*....|....*....|....*....|....*....
gi 2462555497  729 SAIPEgqFIDSKKACEKLLASIDIDHTQYKFGHTKVFFK 767
Cdd:cd14887    689 MALRE--ALTPKMFCKIVLMFLEINSNSYTFGKTKIFFR 725
MYSc_Myo17 cd14879
class XVII myosin, motor domain; This fungal myosin which is also known as chitin synthase ...
97-766 2.16e-86

class XVII myosin, motor domain; This fungal myosin which is also known as chitin synthase uses its motor domain to tether its vesicular cargo to peripheral actin. It works in opposition to dynein, contributing to the retention of Mcs1 vesicles at the site of cell growth and increasing vesicle fusion necessary for polarized growth. Class 17 myosins consist of a N-terminal myosin motor domain with Cyt-b5, chitin synthase 2, and a DEK_C domains at it C-terminus. The chitin synthase region contains several transmembrane domains by which myosin 17 is thought to bind secretory vesicles. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276845 [Multi-domain]  Cd Length: 647  Bit Score: 297.54  E-value: 2.16e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   97 LNEPAVLYNLKDRYTSWMIYTY---SGLfcVTVNPYKWLPVYNPEVVEGYR-------GKKRQEAPPHIFSISDNAYQFM 166
Cdd:cd14879      1 PSDDAITSHLASRFRSDLPYTRlgsSAL--VAVNPYKYLSSNSDASLGEYGseyydttSGSKEPLPPHAYDLAARAYLRM 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  167 LTDRENQSILITGESGAGKTVNTKRVIQYFATIAAtgdlAKKKDSKmkgtLEDQIISANPLLEAFGNAKTVRNDNSSRFG 246
Cdd:cd14879     79 RRRSEDQAVVFLGETGSGKSESRRLLLRQLLRLSS----HSKKGTK----LSSQISAAEFVLDSFGNAKTLTNPNASRFG 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  247 KFIRIHFGTTGKLASADIETYLLEKSRVTfQLKA-ERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQG---EILVA 322
Cdd:cd14879    151 RYTELQFNERGRLIGAKVLDYRLERSRVA-SVPTgERNFHVFYYLLAGASPEERQHLGLDDPSDYALLASYGchpLPLGP 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  323 SIDDAE--ELLATdsAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQ--REEQAEPDGTEVADKTAYLMGLNSSDLLK 398
Cdd:cd14879    230 GSDDAEgfQELKT--ALKTLGFKRKHVAQICQLLAAILHLGNLEFTYDHegGEESAVVKNTDVLDIVAAFLGVSPEDLET 307
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  399 ALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQL-DTKLPRQHFIGVLDIAGFEIF---EYNSL 474
Cdd:cd14879    308 SLTYKTKLVRKELCTVFLDPEGAAAQRDELARTLYSLLFAWVVETINQKLcAPEDDFATFISLLDFPGFQNRsstGGNSL 387
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  475 EQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFgMDLAACIELI-EKPMGIFSILEEEC-MFPKATDTSFKNK 552
Cdd:cd14879    388 DQFCVNFANERLHNYVLRSFFERKAEELEAEGVSVPATSY-FDNSDCVRLLrGKPGGLLGILDDQTrRMPKKTDEQMLEA 466
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  553 LyDQHLGKSNNF-QKPKVVKGRAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVglyqkssnRLLahlyatfatadad 631
Cdd:cd14879    467 L-RKRFGNHSSFiAVGNFATRSGSASFTVNHYAGEVTYSVEGFLERNGDVLSPDFV--------NLL------------- 524
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  632 sgkkkvakkkGSSFQtvsalFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFP 711
Cdd:cd14879    525 ----------RGATQ-----LNAALSELLDTLDRTRLWSVFCIRPNDSQLPNSFDKRRVKAQIRSLGLPELAARLRVEYV 589
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462555497  712 NRILYGDFKQRYrvlnasaIPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFF 766
Cdd:cd14879    590 VSLEHAEFCERY-------KSTLRGSAAERIRQCARANGWWEGRDYVLGNTKVFL 637
MYSc_Myo23 cd14884
class XXIII myosin, motor domain; These myosins are predicted to have a neck region with 1-2 ...
100-715 1.06e-74

class XXIII myosin, motor domain; These myosins are predicted to have a neck region with 1-2 IQ motifs and a single MyTH4 domain in its C-terminal tail. The lack of a FERM domain here is odd since MyTH4 domains are usually found alongside FERM domains where they bind to microtubules. At any rate these Class XXIII myosins are still proposed to function in the apicomplexan microtubule cytoskeleton. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276850 [Multi-domain]  Cd Length: 685  Bit Score: 264.08  E-value: 1.06e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNPEVVEGYRGKKRQEA-------PPHIFSISDNAYQFMLTDRE 171
Cdd:cd14884      1 PNVLQNLKNRYLKNKIYTFHASLLLALNPYKPLKeLYDQDVMNVYLHKKSNSAasaapfpKAHIYDIANMAYKNMRGKLK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  172 NQSILITGESGAGKTVNTKRVIQYFATIaatgdlakKKDSKMKgTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRI 251
Cdd:cd14884     81 RQTIVVSGHSGSGKTENCKFLFKYFHYI--------QTDSQMT-ERIDKLIYINNILESMSNATTIKNNNSSRCGRINLL 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  252 HFGT---------TGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITTNPYDYPFISQGE---- 318
Cdd:cd14884    152 IFEEventqknmfNGCFRNIKIKILLLEINRCIAHNFGERNFHVFYQVLRGLSDEDLARRNLVRNCGVYGLLNPDEshqk 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  319 --------ILVASIDDAEELLATDSA-----IDILGFTPEEK---SGLYKLTGAVMHYGNMKFKQkqreeqaepdgteva 382
Cdd:cd14884    232 rsvkgtlrLGSDSLDPSEEEKAKDEKnfvalLHGLHYIKYDErqiNEFFDIIAGILHLGNRAYKA--------------- 296
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  383 dkTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRIN----------QQLDTKL 452
Cdd:cd14884    297 --AAECLQIEEEDLENVIKYKNIRVSHEVIRTERRKENATSTRDTLIKFIYKKLFNKIIEDINrnvlkckekdESDNEDI 374
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  453 PR--QHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDfgmdLAACIELIEKPMG 530
Cdd:cd14884    375 YSinEAIISILDIYGFEELSGNDFDQLCINLANEKLNNYYINNEIEKEKRIYARENIICCSDV----APSYSDTLIFIAK 450
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  531 IFSILEEECMFP----KATDTSFKNKLYD----QHLGKSNNFQK--PKVVKGRAEAH------FSLIHYAGTVDYSVSGW 594
Cdd:cd14884    451 IFRRLDDITKLKnqgqKKTDDHFFRYLLNnerqQQLEGKVSYGFvlNHDADGTAKKQnikkniFFIRHYAGLVTYRINNW 530
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  595 LEKNKDPLNETVVGLYQKSSNRLLAHlyatfATADADSGkkkvakkkgsSFQTVSALFRENLNKLMSNLRTTHPHFVRCI 674
Cdd:cd14884    531 IDKNSDKIETSIETLISCSSNRFLRE-----ANNGGNKG----------NFLSVSKKYIKELDNLFTQLQSTDMYYIRCF 595
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|.
gi 2462555497  675 IPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRIL 715
Cdd:cd14884    596 LPNAKMLPNTFKRLLVYRQLKQCGSNEMIKILNRGLSHKIP 636
MYSc_Myo20 cd14881
class XX myosin, motor domain; These class 20 myosins are primarily insect myosins with such ...
101-749 3.23e-72

class XX myosin, motor domain; These class 20 myosins are primarily insect myosins with such members as Drosophila, Daphnia, and mosquitoes. These myosins contain a single IQ motif in the neck region. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276847 [Multi-domain]  Cd Length: 633  Bit Score: 255.42  E-value: 3.23e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPvyNPEVVEGYRGKKRQeapPHIFSISDNAYQFMLTDRENQSILITGE 180
Cdd:cd14881      2 AVMKCLQARFYAKEFFTNVGPILLSVNPYRDVG--NPLTLTSTRSSPLA---PQLLKVVQEAVRQQSETGYPQAIILSGT 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  181 SGAGKTVNTKRVIQYFATIAATG---DLAKkkdskmkgtledQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFgTTG 257
Cdd:cd14881     77 SGSGKTYASMLLLRQLFDVAGGGpetDAFK------------HLAAAFTVLRSLGSAKTATNSESSRIGHFIEVQV-TDG 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  258 KLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKP-ELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSA 336
Cdd:cd14881    144 ALYRTKIHCYFLDQTRVIRPLPGEKNYHIFYQMLAGLSQeERVKLHLDGYSPANLRYLSHGDTRQNEAEDAARFQAWKAC 223
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  337 IDILG--FTpeeksGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVaDKTAYLMGLNSSDLLKALCFPRVKVGNEYVTK 414
Cdd:cd14881    224 LGILGipFL-----DVVRVLAAVLLLGNVQFIDGGGLEVDVKGETEL-KSVAALLGVSGAALFRGLTTRTHNARGQLVKS 297
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  415 GQTVDQVHHAVNALSKSVYEKLFLWMVTRINQqldtkLPRQH----------FIGVLDIAGFEIFEYNSLEQLCINFTNE 484
Cdd:cd14881    298 VCDANMSNMTRDALAKALYCRTVATIVRRANS-----LKRLGstlgthatdgFIGILDMFGFEDPKPSQLEHLCINLCAE 372
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  485 KLQQFFNHHMFVLEQEEYKKEGIEwTFIDFG-MDLAACIELIEK-PMGIFSILEEECMfPKATDTSFKNKLYDQHlgKSN 562
Cdd:cd14881    373 TMQHFYNTHIFKSSIESCRDEGIQ-CEVEVDyVDNVPCIDLISSlRTGLLSMLDVECS-PRGTAESYVAKIKVQH--RQN 448
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  563 N-FQKPKVVKGRAeahFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLlahlyaTFATADADsgkkkvakkk 641
Cdd:cd14881    449 PrLFEAKPQDDRM---FGIRHFAGRVVYDASDFLDTNRDVVPDDLVAVFYKQNCNF------GFATHTQD---------- 509
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  642 gssFQTvsalfreNLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQ 721
Cdd:cd14881    510 ---FHT-------RLDNLLRTLVHARPHFVRCIRSNTTETPNHFDRGTVVRQIRSLQVLETVNLMAGGYPHRMRFKAFNA 579
                          650       660
                   ....*....|....*....|....*...
gi 2462555497  722 RYRVLnASAIPEGQFIDSKKACEKLLAS 749
Cdd:cd14881    580 RYRLL-APFRLLRRVEEKALEDCALILQ 606
MYSc_Myo44 cd14905
class XLIV myosin, motor domain; There is little known about the function of the myosin XLIV ...
106-719 1.28e-67

class XLIV myosin, motor domain; There is little known about the function of the myosin XLIV class. Members here include cellular slime mold Polysphondylium and soil-living amoeba Dictyostelium. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276870  Cd Length: 673  Bit Score: 243.08  E-value: 1.28e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  106 LKDRYTSWMIYTYSGLFCVTVNPYKWLP-VYNPEVVEGYrgKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAG 184
Cdd:cd14905      7 IQARYKKEIIYTYIGPILVSVNPLRYLPfLHSQELVRNY--NQRRGLPPHLFALAAKAISDMQDFRRDQLIFIGGESGSG 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  185 KTVNTKRVIQYFATIaatgDLAKKKdskmkgTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADI 264
Cdd:cd14905     85 KSENTKIIIQYLLTT----DLSRSK------YLRDYILESGIILESFGHASTDSNHNSSRWGKYFEMFYSLYGEIQGAKL 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  265 ETYLLEKSRVTFQLKAERSYHIFYQILSN-KKPELIELLLITTNPYDYpfISQ-GEILVASIDDAEELLATDSAIDILGF 342
Cdd:cd14905    155 YSYFLDENRVTYQNKGERNFHIFYQFLKGiTDEEKAAYQLGDINSYHY--LNQgGSISVESIDDNRVFDRLKMSFVFFDF 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  343 TPEEKSGLYKLTGAVMHYGNMKFKQKQREeqaepdgTEVADKTAYlmglnsSDLLKALCFPRVKVGNEYVT-KGQTVDQV 421
Cdd:cd14905    233 PSEKIDLIFKTLSFIIILGNVTFFQKNGK-------TEVKDRTLI------ESLSHNITFDSTKLENILISdRSMPVNEA 299
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  422 HHAVNALSKSVYEKLFLWMVTRINQQLDtklPRQ--HFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQ 499
Cdd:cd14905    300 VENRDSLARSLYSALFHWIIDFLNSKLK---PTQysHTLGILDLFGQESSQLNGYEQFSINFLEERLQQIYLQTVLKQEQ 376
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  500 EEYKKEGIEW-TFIDFgMDLAACIELIEKpmgIFSILEEECMFPKATDTSFKNKLydqhlgksNNFQKPKVVKGRAEAHF 578
Cdd:cd14905    377 REYQTERIPWmTPISF-KDNEESVEMMEK---IINLLDQESKNINSSDQIFLEKL--------QNFLSRHHLFGKKPNKF 444
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  579 SLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATF----ATADADSGKKKVAKKKGSSFQTVSALFR- 653
Cdd:cd14905    445 GIEHYFGQFYYDVRGFIIKNRDEILQRTNVLHKNSITKYLFSRDGVFninaTVAELNQMFDAKNTAKKSPLSIVKVLLSc 524
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  654 -----ENLNKLMSN-------------------LRTTHP-------------HFVRCIIPNETKTPGAMEHSLVLHQLRC 696
Cdd:cd14905    525 gsnnpNNVNNPNNNsgggggggnsgggsgsggsTYTTYSstnkainnsncdfHFIRCIKPNSKKTHLTFDVKSVNEQIKS 604
                          650       660
                   ....*....|....*....|....*..
gi 2462555497  697 NGVLEGIRICRKGFP----NRILYGDF 719
Cdd:cd14905    605 LCLLETTRIQRFGYTihynNKIFFDRF 631
MYSc_Myo12 cd14874
class XXXIII myosin, motor domain; Little is known about the XXXIII class of myosins. They ...
101-726 3.76e-66

class XXXIII myosin, motor domain; Little is known about the XXXIII class of myosins. They are found predominately in nematodes. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276841 [Multi-domain]  Cd Length: 628  Bit Score: 237.46  E-value: 3.76e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  101 AVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYrgkkrqeappHIFSISDNAYQFMLTDREN-QSILITG 179
Cdd:cd14874      2 GIAQNLHERFKKGQTYTKASNVLVFVNDFNKLSIQDQLVIKKC----------HISGVAENALDRIKSMSSNaESIVFGG 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  180 ESGAGKTVNTKRVIQYfatiaatgdLAKKKDSKMKGTLEDQIISanpLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKL 259
Cdd:cd14874     72 ESGSGKSYNAFQVFKY---------LTSQPKSKVTTKHSSAIES---VFKSFGCAKTLKNDEATRFGCSIDLLYKRNVLT 139
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  260 ASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKKPELIELLLITtNPYDYPFISQGEILVASIDDAEELLATDSAIDI 339
Cdd:cd14874    140 GLNLKYTVPLEVPRVISQKPGERNFNVFYEVYHGLNDEMKAKFGIK-GLQKFFYINQGNSTENIQSDVNHFKHLEDALHV 218
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  340 LGFTPEEKSGLYKLTGAVMHYGNMKFKQKqREEQAEPDGTEVADKT-----AYLMGLNSSDLLKALcFPRVKVGNEYvtk 414
Cdd:cd14874    219 LGFSDDHCISIYKIISTILHIGNIYFRTK-RNPNVEQDVVEIGNMSevkwvAFLLEVDFDQLVNFL-LPKSEDGTTI--- 293
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  415 gqTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLpRQHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHM 494
Cdd:cd14874    294 --DLNAALDNRDSFAMLIYEELFKWVLNRIGLHLKCPL-HTGVISILDHYGFEKYNNNGVEEFLINSVNERIENLFVKHS 370
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  495 FVLEQEEYKKEGIEwtfIDFGM----DLAACIELI-EKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSnNFQKPKv 569
Cdd:cd14874    371 FHDQLVDYAKDGIS---VDYKVpnsiENGKTVELLfKKPYGLLPLLTDECKFPKGSHESYLEHCNLNHTDRS-SYGKAR- 445
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  570 VKGRAEahFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATADADSGKKKVAKKKGSSFQTVs 649
Cdd:cd14874    446 NKERLE--FGVRHCIGTTWYNVTDFFSRNKRIISLSAVQLLRSSKNPIIGLLFESYSSNTSDMIVSQAQFILRGAQEIA- 522
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462555497  650 alfrENLNKlmsnlrtTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVL 726
Cdd:cd14874    523 ----DKING-------SHAHFVRCIKSNNERQPKKFDIPLVNRQIKNLLLAELLSFRIKGYPVKISKTTFARQYRCL 588
MYSc_Myo21 cd14882
class XXI myosin, motor domain; The myosins here are comprised of insects. Leishmania class ...
102-767 9.05e-65

class XXI myosin, motor domain; The myosins here are comprised of insects. Leishmania class XXI myosins do not group with them. Myo21, unlike other myosin proteins, contains UBA-like protein domains and has no structural or functional relationship with the myosins present in other organisms possessing cilia or flagella. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. They have diverse tails with IQ, WW, PX, and Tub domains. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276848  Cd Length: 642  Bit Score: 233.86  E-value: 9.05e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  102 VLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGES 181
Cdd:cd14882      3 ILEELRHRYLMGESYTFIGDILLSLNPNEIKQEYPQEFHAKYRCKSRSDNAPHIFSVADSAYQDMLHHEEPQHIILSGES 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  182 GAGKTVNTKRVIQYFATIAatgdlakkkdsKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLAS 261
Cdd:cd14882     83 YSGKTTNARLLIKHLCYLG-----------DGNRGATGRVESSIKAILALVNAGTPLNADSTRCILQYQLTFGSTGKMSG 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  262 ADIETYLLEKSRVTFQLKAERSYHIFYQILS--NKKPELIELLLITTNPYDYPFISQG-------------EILVASIDD 326
Cdd:cd14882    152 AIFWMYQLEKLRVSTTDGNQSNFHIFYYFYDfiEAQNRLKEYNLKAGRNYRYLRIPPEvppsklkyrrddpEGNVERYKE 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  327 AEELLAtdsaidILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREeqAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVK 406
Cdd:cd14882    232 FEEILK------DLDFNEEQLETVRKVLAAILNLGEIRFRQNGGY--AELENTEIASRVAELLRLDEKKFMWALTNYCLI 303
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  407 VGNEYVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLdtKLPR-----QHFIGVLDIAGFEIFEYNSLEQLCINF 481
Cdd:cd14882    304 KGGSAERRKHTTEEARDARDVLASTLYSRLVDWIINRINMKM--SFPRavfgdKYSISIHDMFGFECFHRNRLEQLMVNT 381
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  482 TNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEecmfpKATDTSFKNKLYDQHLGKS 561
Cdd:cd14882    382 LNEQMQYHYNQRIFISEMLEMEEEDIPTINLRFYDNKTAVDQLMTKPDGLFYIIDD-----ASRSCQDQNYIMDRIKEKH 456
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  562 NNFQKPkvvkgrAEAH-FSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATadadsgkkkvakk 640
Cdd:cd14882    457 SQFVKK------HSAHeFSVAHYTGRIIYDAREFADKNRDFVPPEMIETMRSSLDESVKLMFTNSQV------------- 517
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  641 kgSSFQTVSALFR----ENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILY 716
Cdd:cd14882    518 --RNMRTLAATFRatslELLKMLSIGANSGGTHFVRCIRSDLEYKPRGFHSEVVRQQMRALAVLDTAKARQKGFSYRIPF 595
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462555497  717 GDFKQRYRVLnasAIPEGQFID-SKKACEKLLasIDIDHTQYKFGHTKVFFK 767
Cdd:cd14882    596 QEFLRRYQFL---AFDFDETVEmTKDNCRLLL--IRLKMEGWAIGKTKVFLK 642
MYSc_Myo32 cd14893
class XXXII myosin, motor domain; Class XXXII myosins do not contain any IQ motifs, but ...
103-724 4.57e-63

class XXXII myosin, motor domain; Class XXXII myosins do not contain any IQ motifs, but possess tandem MyTH4 and FERM domains. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276858  Cd Length: 741  Bit Score: 231.01  E-value: 4.57e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  103 LYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYRGKKRQ----------EAPPHIFSISDNAYQFMLTDREN 172
Cdd:cd14893      4 LYTLRARYRMEQVYTWVDRVLVGVNPVTPLPIYTPDHMQAYNKSREQtplyekdtvnDAPPHVFALAQNALRCMQDAGED 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  173 QSILITGESGAGKTVNTKRVIQYFATIAATGDLA--KKKDSKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIR 250
Cdd:cd14893     84 QAVILLGGMGAGKSEAAKLIVQYLCEIGDETEPRpdSEGASGVLHPIGQQILHAFTILEAFGNAATRQNRNSSRFAKMIS 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  251 IHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQILSNKK--PELIELLLITTNPYDYPFISQGEILVASID-DA 327
Cdd:cd14893    164 VEFSKHGHVIGGGFTTHYFEKSRVIDCRSHERNFHVFYQVLAGVQhdPTLRDSLEMNKCVNEFVMLKQADPLATNFAlDA 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  328 EELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDG--TEVADKTAYLMGLNSSDLLKALCF--- 402
Cdd:cd14893    244 RDYRDLMSSFSALRIRKNQRVEIVRIVAALLHLGNVDFVPDPEGGKSVGGAnsTTVSDAQSCALKDPAQILLAAKLLeve 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  403 PRV------------KVGNEYVT--KGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQQLDTKLPR---------QHFIG 459
Cdd:cd14893    324 PVVldnyfrtrqffsKDGNKTVSslKVVTVHQARKARDTFVRSLYESLFNFLVETLNGILGGIFDRyeksnivinSQGVH 403
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  460 VLDIAGFEIFE--YNSLEQLCINFTNEKLQQFFNHHMFV-----LEQEEYKKEG--IEWTFIDFGMDLAACIELIE-KPM 529
Cdd:cd14893    404 VLDMVGFENLTpsQNSFDQLCFNYWSEKVHHFYVQNTLAinfsfLEDESQQVENrlTVNSNVDITSEQEKCLQLFEdKPF 483
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  530 GIFSILEEECMFPKATDTSFKNKLY---DQHLGKSNNFQKPKVVKGRAEAH------FSLIHYAGTVDYSVSGWLEKNKD 600
Cdd:cd14893    484 GIFDLLTENCKVRLPNDEDFVNKLFsgnEAVGGLSRPNMGADTTNEYLAPSkdwrllFIVQHHCGKVTYNGKGLSSKNML 563
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  601 PLNETVVGLYQKSSNRLL-AHLYATFATADADSGKKKVAK--KKGSSFQTVSALFRENLN--------------KLMSNL 663
Cdd:cd14893    564 SISSTCAAIMQSSKNAVLhAVGAAQMAAASSEKAAKQTEErgSTSSKFRKSASSARESKNitdsaatdvynqadALLHAL 643
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462555497  664 RTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYR 724
Cdd:cd14893    644 NHTGKNFLVCIKPNETLEEGVFDSAYVMKQIRMNHLVELMQASRSIFTVHLTYGHFFRRYK 704
Motor_domain cd01363
Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the ...
122-251 5.25e-60

Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes. Some of the names do not match with what is given in the sequence list. This is because they are based on the current nomenclature by Kollmar/Sebe-Pedros.


Pssm-ID: 276814 [Multi-domain]  Cd Length: 170  Bit Score: 203.73  E-value: 5.25e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  122 FCVTVNPYKWLPVYNPEVVEG-YRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIA 200
Cdd:cd01363      1 VLVRVNPFKELPIYRDSKIIVfYRGFRRSESQPHVFAIADPAYQSMLDGYNNQSIFAYGESGAGKTETMKGVIPYLASVA 80
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462555497  201 ATGDLAKKKD-----SKMKGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRI 251
Cdd:cd01363     81 FNGINKGETEgwvylTEITVTLEDQILQANPILEAFGNAKTTRNENSSRFGKFIEI 136
MYSc_Myo24B cd14938
class XXIV B myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a ...
100-765 2.22e-49

class XXIV B myosin, motor domain; These myosins have a 1-2 IQ motifs in their neck and a coiled-coil region in their C-terminal tail. The functions of these myosins remain elusive. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276898 [Multi-domain]  Cd Length: 713  Bit Score: 189.28  E-value: 2.22e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  100 PAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVEGYR-GKKRQEAPPHIFSISDNAYQFMLTDRENQSILIT 178
Cdd:cd14938      1 PSVLYHLKERFKNNKFYTKMGPLLIFINPKINNNINNEETIEKYKcIDCIEDLSLNEYHVVHNALKNLNELKRNQSIIIS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  179 GESGAGKTVNTKRVIQYFATIA------ATGDLAKKKDSKM-------KGTLEDQIISANPLLEAFGNAKTVRNDNSSRF 245
Cdd:cd14938     81 GESGSGKSEIAKNIINFIAYQVkgsrrlPTNLNDQEEDNIHneentdyQFNMSEMLKHVNVVMEAFGNAKTVKNNNSSRF 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  246 GKFIRIHFGTTgKLASADIETYLLEKSRVTFQLKAERSYHIFYQILsNKKPELIELLLITTNPYDYPFISQGEILVASID 325
Cdd:cd14938    161 SKFCTIHIENE-EIKSFHIKKFLLDKERLINRKANENSFNIFYYII-NGSSDKFKKMYFLKNIENYSMLNNEKGFEKFSD 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  326 DAEELLATDSAIDILGFTPEEKSGLYKLTGAVMHYGN-------------MKFKQKQRE----------EQAEPDGTEVA 382
Cdd:cd14938    239 YSGKILELLKSLNYIFDDDKEIDFIFSVLSALLLLGNteivkafrkksllMGKNQCGQNinyetilselENSEDIGLDEN 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  383 DKTAYL----MGLNSSDLLKAlcFPRVKVGNEYV-TKGQTVDQVHHAVNALSKSVYEKLFLWMVTRINQ---QLDTKLPR 454
Cdd:cd14938    319 VKNLLLacklLSFDIETFVKY--FTTNYIFNDSIlIKVHNETKIQKKLENFIKTCYEELFNWIIYKINEkctQLQNININ 396
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  455 QHFIGVLDIAGFEIFEYNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPM--GIF 532
Cdd:cd14938    397 TNYINVLDMAYFENSKDNSLEQLLINTTNEEIIKIKNDCLYKKRVLSYNEDGIFCEYNSENIDNEPLYNLLVGPTegSLF 476
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  533 SILEEECMfPKATDTSFKNKLYDQHLGKSNNFQKPKVVKGRAEAhFSLIHYAGTVDYSVSGWLEKNKDPLNETVVGLYQK 612
Cdd:cd14938    477 SLLENVST-KTIFDKSNLHSSIIRKFSRNSKYIKKDDITGNKKT-FVITHSCGDIIYNAENFVEKNIDILTNRFIDMVKQ 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  613 SSNRLLAHLYATFataDADSGKKKVAKKKGSSFQTVSALF---------------RENLNKLMSNLRTTHPHFVRCIIPN 677
Cdd:cd14938    555 SENEYMRQFCMFY---NYDNSGNIVEEKRRYSIQSALKLFkrrydtknqmavsllRNNLTELEKLQETTFCHFIVCMKPN 631
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  678 ETKTP-GAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNAsaipegqfiDSKKACEKLLASIDIDHTQ 756
Cdd:cd14938    632 ESKRElCSFDANIVLRQVRNFSIVEASQLKVGYYPHKFTLNEFLSIFDIKNE---------DLKEKVEALIKSYQISNYE 702

                   ....*....
gi 2462555497  757 YKFGHTKVF 765
Cdd:cd14938    703 WMIGNNMIF 711
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1173-1928 4.05e-28

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 124.40  E-value: 4.05e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1173 LKLRRDLEEATLQHEAMVATLrKKHADSVAELGEQIDNLQRVKQKLEK-----------EKSEFKLEIDDLSSSMESVSK 1241
Cdd:TIGR02168  168 SKYKERRKETERKLERTRENL-DRLEDILNELERQLKSLERQAEKAERykelkaelrelELALLVLRLEELREELEELQE 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1242 SKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLE 1321
Cdd:TIGR02168  247 ELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLE 326
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1322 EENKAKNALAHALQSsrhdcdlLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETdaiqRTEELEEAKKKLAQRlqds 1401
Cdd:TIGR02168  327 ELESKLDELAEELAE-------LEEKLEELKEELESLEAELEELEAELEELESRLEE----LEEQLETLRSKVAQL---- 391
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1402 EEQVEAVNAKCASLEKTKQRLQGEVEDLmvdVERANSLAAALDKKQrnfdkvLAEWKTKCEESQAELEASLKESRSLSTE 1481
Cdd:TIGR02168  392 ELQIASLNNEIERLEARLERLEDRRERL---QQEIEELLKKLEEAE------LKELQAELEELEEELEELQEELERLEEA 462
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1482 LFKLKNAYEEALDQLETVKRENKNLEQEIA---DLTEQIAENGKTIHELEKSRKQI---------------ELEKADIQL 1543
Cdd:TIGR02168  463 LEELREELEEAEQALDAAERELAQLQARLDsleRLQENLEGFSEGVKALLKNQSGLsgilgvlselisvdeGYEAAIEAA 542
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1544 ALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDL 1623
Cdd:TIGR02168  543 LGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLL 622
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1624 NEIEI--QLSHANRQAAETLKHLRSVQgqLKDTQLHLDDALRGQEDlKEQLAIVERRANL--LQAEVEELRATLEQTERA 1699
Cdd:TIGR02168  623 GGVLVvdDLDNALELAKKLRPGYRIVT--LDGDLVRPGGVITGGSA-KTNSSILERRREIeeLEEKIEELEEKIAELEKA 699
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1700 RKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1779
Cdd:TIGR02168  700 LAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAE 779
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1780 LERMKKNLEQTVKDLQhrldeaeqlalkggkKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDR 1859
Cdd:TIGR02168  780 AEAEIEELEAQIEQLK---------------EELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLE 844
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462555497 1860 KNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDF 1928
Cdd:TIGR02168  845 EQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSEL 913
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
840-1453 2.69e-26

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 118.12  E-value: 2.69e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  840 LLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAK 919
Cdd:COG1196    231 LLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER 310
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  920 IKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKA 999
Cdd:COG1196    311 RRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1000 LQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDE 1079
Cdd:COG1196    391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLE 470
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1080 RLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQ--RSDYARELEELSERLEEAGGV 1157
Cdd:COG1196    471 EAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAvlIGVEAAYEAALEAALAAALQN 550
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1158 TSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRvkqkLEKEKSEFKLEIDDLSSSME 1237
Cdd:COG1196    551 IVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVAS----DLREADARYYVLGDTLLGRT 626
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1238 SVSKSKANLEKICRTLEDQLSEARGKNEEIQRSlselttqKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELK 1317
Cdd:COG1196    627 LVAARLEAALRRAVTLAGRLREVTLEGEGGSAG-------GSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEAL 699
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1318 RQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAqwrtKYETDAIQRTEELEEAKKKLAQR 1397
Cdd:COG1196    700 LAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEA----LEELPEPPDLEELERELERLERE 775
                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462555497 1398 LQD-------SEEQVEAVNAKCASLEKTKQRLQGEVEDLM-----VDVERANSLAAALDKKQRNFDKV 1453
Cdd:COG1196    776 IEAlgpvnllAIEEYEELEERYDFLSEQREDLEEARETLEeaieeIDRETRERFLETFDAVNENFQEL 843
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
921-1852 2.81e-26

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 118.24  E-value: 2.81e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  921 KEVTERAEDEEEINAEltakkrKLEDECSELKKDIDDLELTLAKVEKekhatenkVKNLTEELSGLDetIAKLTREKKAL 1000
Cdd:TIGR02168  174 RKETERKLERTRENLD------RLEDILNELERQLKSLERQAEKAER--------YKELKAELRELE--LALLVLRLEEL 237
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1001 QEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQekklrvdLERNKRKLEGDLKLAQESILDLENDKQQLDER 1080
Cdd:TIGR02168  238 REELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSE-------LEEEIEELQKELYALANEISRLEQQKQILRER 310
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1081 LKkkdfeycQLQSKVEDEQTLGLQFQKKIKELQARIeeleeeieaeraTRAKTEKQrsdyareleelserleeaggVTST 1160
Cdd:TIGR02168  311 LA-------NLERQLEELEAQLEELESKLDELAEEL------------AELEEKLE--------------------ELKE 351
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1161 QIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKhadsVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVS 1240
Cdd:TIGR02168  352 ELESLEAELEELEAELEELESRLEELEEQLETLRSK----VAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELL 427
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1241 KSKAnlekicrtlEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQL 1320
Cdd:TIGR02168  428 KKLE---------EAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQ 498
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1321 EEE----NKAKNALAHALQSSRHDcDLLREQYEEEQEGKAELQRALSKANSEVAqwrTKYETDAIQRTEELEEAKK---- 1392
Cdd:TIGR02168  499 ENLegfsEGVKALLKNQSGLSGIL-GVLSELISVDEGYEAAIEAALGGRLQAVV---VENLNAAKKAIAFLKQNELgrvt 574
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1393 ----------KLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQrnfdkvlaewKTKCE 1462
Cdd:TIGR02168  575 flpldsikgtEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELAK----------KLRPG 644
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1463 ESQAELEASLKESRSLSTelfklKNAYEEALDQLETvKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQ 1542
Cdd:TIGR02168  645 YRIVTLDGDLVRPGGVIT-----GGSAKTNSSILER-RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLR 718
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1543 LALEEAEAALEHEEAKILRIQLELTQVKSEIDRkIAEKDEEIEQLKRNYQRTVETMQSALDaevrsrnEAIRLKKKMEGD 1622
Cdd:TIGR02168  719 KELEELSRQISALRKDLARLEAEVEQLEERIAQ-LSKELTELEAEIEELEERLEEAEEELA-------EAEAEIEELEAQ 790
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1623 LNEIEIQLSHANRQaaetlkhLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQterarkl 1702
Cdd:TIGR02168  791 IEQLKEELKALREA-------LDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIES------- 856
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1703 AEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKaitdaammaeelkkeqdtsahLER 1782
Cdd:TIGR02168  857 LAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSE---------------------LRR 915
                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462555497 1783 MKKNLEQTVKDLQHRLDEAEQlalkggkkQIQKLETRIREL-EFELEGEQKKNTESVKGLRKYERRVKELT 1852
Cdd:TIGR02168  916 ELEELREKLAQLELRLEGLEV--------RIDNLQERLSEEySLTLEEAEALENKIEDDEEEARRRLKRLE 978
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
931-1872 5.44e-26

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 117.46  E-value: 5.44e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  931 EEINAELTAKKRKLEDECS------ELKKDIDDLELTLAKVEKEKHatENKVKNLTEELSGLDETIAKLTREKKALQEAH 1004
Cdd:TIGR02168  192 EDILNELERQLKSLERQAEkaerykELKAELRELELALLVLRLEEL--REELEELQEELKEAEEELEELTAELQELEEKL 269
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1005 QQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQekklrvdLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKK 1084
Cdd:TIGR02168  270 EELRLEVSELEEEIEELQKELYALANEISRLEQQKQI-------LRERLANLERQLEELEAQLEELESKLDELAEELAEL 342
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1085 DFEYCQLQSKVEDEQTLGLQFQKKIKELQarieeleeeieaeratraktekqrsdyareleelserleeaggvtstqiEL 1164
Cdd:TIGR02168  343 EEKLEELKEELESLEAELEELEAELEELE-------------------------------------------------SR 373
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1165 NKKREAEFLKLRRDLEEATLQHEAMVATLRkkhadsvaELGEQIDNLQRVKQKLEKEKSEFKLEIDdlsssmesvskska 1244
Cdd:TIGR02168  374 LEELEEQLETLRSKVAQLELQIASLNNEIE--------RLEARLERLEDRRERLQQEIEELLKKLE-------------- 431
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1245 nlekicrtlEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEE- 1323
Cdd:TIGR02168  432 ---------EAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLe 502
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1324 ---NKAKNALAHALQSSRHDcDLLREQYEEEQEGKAELQRALSKANSEVAqwrTKYETDAIQRTEELEEAKK-------- 1392
Cdd:TIGR02168  503 gfsEGVKALLKNQSGLSGIL-GVLSELISVDEGYEAAIEAALGGRLQAVV---VENLNAAKKAIAFLKQNELgrvtflpl 578
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1393 ------KLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQrnfdkvlaewKTKCEESQA 1466
Cdd:TIGR02168  579 dsikgtEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELAK----------KLRPGYRIV 648
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1467 ELEASLKESRSLSTelfklKNAYEEALDQLETvKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALE 1546
Cdd:TIGR02168  649 TLDGDLVRPGGVIT-----GGSAKTNSSILER-RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELE 722
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1547 EAEAALEHEEAKILRIQLELTQVKSEIDRkIAEKDEEIEQLKRNYQRTVETMQSALDaevrsrnEAIRLKKKMEGDLNEI 1626
Cdd:TIGR02168  723 ELSRQISALRKDLARLEAEVEQLEERIAQ-LSKELTELEAEIEELEERLEEAEEELA-------EAEAEIEELEAQIEQL 794
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1627 EIQLSHANRQaaetlkhLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQterarklAEQE 1706
Cdd:TIGR02168  795 KEELKALREA-------LDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIES-------LAAE 860
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1707 LLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQdtsAHLERMKKN 1786
Cdd:TIGR02168  861 IEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLE---LRLEGLEVR 937
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1787 LEQTVKDL--QHRLDEAEQLALK-GGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVL 1863
Cdd:TIGR02168  938 IDNLQERLseEYSLTLEEAEALEnKIEDDEEEARRRLKRLENKIKELGPVNLAAIEEYEELKERYDFLTAQKEDLTEAKE 1017

                   ....*....
gi 2462555497 1864 RLQDLVDKL 1872
Cdd:TIGR02168 1018 TLEEAIEEI 1026
MYSc_Myo33 cd14894
class myosin, motor domain; Class XXXIII myosins have variable numbers of IQ domain and 2 ...
221-707 6.77e-25

class myosin, motor domain; Class XXXIII myosins have variable numbers of IQ domain and 2 tandem ANK repeats that are separated by a PH domain. The myosin classes XXX to XXXIV contain members from Phytophthora species and Hyaloperonospora parasitica. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.


Pssm-ID: 276859 [Multi-domain]  Cd Length: 871  Bit Score: 113.30  E-value: 6.77e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  221 IISANPLLEAFGNAKTVRNDNSSRFGKF--IRIHFGTTG---KLASADIETYLLEKSRVTFQL------KAERSYHIFYQ 289
Cdd:cd14894    249 VLDSNIVLEAFGHATTSMNLNSSRFGKMttLQVAFGLHPwefQICGCHISPFLLEKSRVTSERgresgdQNELNFHILYA 328
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  290 ILS--NKKPEL----IELLLITTNPYDYPFISQGEILVASIDDAEELLATD--------SAIDILGFTPEEKSGLYKLTG 355
Cdd:cd14894    329 MVAgvNAFPFMrllaKELHLDGIDCSALTYLGRSDHKLAGFVSKEDTWKKDverwqqviDGLDELNVSPDEQKTIFKVLS 408
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  356 AVMHYGNMKFKQKQREEQAEPDGT---EVADKTAYLMGLNSSDLLKALCFPR-VKVGNEYVTKGQTVD--QVHHAVNALS 429
Cdd:cd14894    409 AVLWLGNIELDYREVSGKLVMSSTgalNAPQKVVELLELGSVEKLERMLMTKsVSLQSTSETFEVTLEkgQVNHVRDTLA 488
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  430 KSVYEKLFLWMVTRINQ--------------QLDTKLPRQHFIGVL---DIAGFEIFEYNSLEQLCINFTNEKLqqFFNH 492
Cdd:cd14894    489 RLLYQLAFNYVVFVMNEatkmsalstdgnkhQMDSNASAPEAVSLLkivDVFGFEDLTHNSLDQLCINYLSEKL--YARE 566
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  493 HMFVLEQEEYKKEGIEWtfiDFGMDLaacIELIEKPMGIFSILEEECMFPKATDTSF-----KNKLYDQHLGKSNN--FQ 565
Cdd:cd14894    567 EQVIAVAYSSRPHLTAR---DSEKDV---LFIYEHPLGVFASLEELTILHQSENMNAqqeekRNKLFVRNIYDRNSsrLP 640
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  566 KPKVVKGRAEAH---------FSLIHYAGTVDYSVSGWLEKNKDPL-NETVVGLYQKSSN---RLLAHLYATFATADADS 632
Cdd:cd14894    641 EPPRVLSNAKRHtpvllnvlpFVIPHTRGNVIYDANDFVKKNSDFVyANLLVGLKTSNSShfcRMLNESSQLGWSPNTNR 720
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462555497  633 GKKKVAKKKGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICR 707
Cdd:cd14894    721 SMLGSAESRLSGTKSFVGQFRSHVNVLTSQDDKNMPFYFHCIRPNAKKQPSLVNNDLVEQQCRSQRLIRQMEICR 795
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
841-1732 1.65e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.46  E-value: 1.65e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  841 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKI 920
Cdd:TIGR02168  218 LKAELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEI 297
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  921 KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKAL 1000
Cdd:TIGR02168  298 SRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEEL 377
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1001 QEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLErnKRKLEGDLKLAQESILDLENDKQQLDER 1080
Cdd:TIGR02168  378 EEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELL--KKLEEAELKELQAELEELEEELEELQEE 455
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1081 LKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAEratrakteKQRSDYARELEELSERLEEAGGVTST 1160
Cdd:TIGR02168  456 LERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENL--------EGFSEGVKALLKNQSGLSGILGVLSE 527
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1161 QIELNKKREAeflklrrdleeatlqheAMVATLRKkHADSVAelgeqIDNLQRVKQKLE--KEKSEFKLEIDDLSSSMEs 1238
Cdd:TIGR02168  528 LISVDEGYEA-----------------AIEAALGG-RLQAVV-----VENLNAAKKAIAflKQNELGRVTFLPLDSIKG- 583
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1239 vskskanlekicRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQ----------------TEAGELSRQLEEKESIVS-- 1300
Cdd:TIGR02168  584 ------------TEIQGNDREILKNIEGFLGVAKDLVKFDPKLRkalsyllggvlvvddlDNALELAKKLRPGYRIVTld 651
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1301 -QLSRSKQAFTQQTEE-----LKRQLE-EENKAKnalahalqssrhdcdlLREQYEEEQEGKAELQrALSKANSEVAQWR 1373
Cdd:TIGR02168  652 gDLVRPGGVITGGSAKtnssiLERRREiEELEEK----------------IEELEEKIAELEKALA-ELRKELEELEEEL 714
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1374 TKYETDAIQRTEELEEAKKKLAQRlqdsEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKV 1453
Cdd:TIGR02168  715 EQLRKELEELSRQISALRKDLARL----EAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQ 790
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1454 LAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENgktIHELEKSRKQ 1533
Cdd:TIGR02168  791 IEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESL---AAEIEELEEL 867
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1534 IELEKADIQlaleeaeaaleheeakilriqlELTQVKSEIDRKIAEKDEEIEQLkRNYQRTVETMQSALDAEVRSRNEAI 1613
Cdd:TIGR02168  868 IEELESELE----------------------ALLNERASLEEALALLRSELEEL-SEELRELESKRSELRRELEELREKL 924
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1614 rlkKKMEGDLNEIEIQLSHANRQAAEtlkhlrsvqgqlkDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEEL-RAT 1692
Cdd:TIGR02168  925 ---AQLELRLEGLEVRIDNLQERLSE-------------EYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELgPVN 988
                          890       900       910       920
                   ....*....|....*....|....*....|....*....|
gi 2462555497 1693 LEqterarklAEQELLDSNERVQLLHTQNTSLIHTKKKLE 1732
Cdd:TIGR02168  989 LA--------AIEEYEELKERYDFLTAQKEDLTEAKETLE 1020
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
847-1529 2.10e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.07  E-value: 2.10e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTL---VQEKNDLQLQVQAESENLLDAEERCD---QLIKAKF-QLEAK 919
Cdd:TIGR02168  238 REELEELQEELKEAEEELEELTAELQELEEKLEELrleVSELEEEIEELQKELYALANEISRLEqqkQILRERLaNLERQ 317
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  920 IKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKA 999
Cdd:TIGR02168  318 LEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIAS 397
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1000 LQEAHQQALDDLQAEEDKVNSLNKTKSKL-----EQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDK 1074
Cdd:TIGR02168  398 LNNEIERLEARLERLEDRRERLQQEIEELlkkleEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQAL 477
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1075 QQLDERLKKKDFEYCQLQSKVEDEQTL--GLQFQKKIKE------------------------------LQARIEELEEE 1122
Cdd:TIGR02168  478 DAAERELAQLQARLDSLERLQENLEGFseGVKALLKNQSglsgilgvlselisvdegyeaaieaalggrLQAVVVENLNA 557
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1123 IEAERATRAKTEKQRS--------DYARELEELSERLEEAGGVTSTQIELNKKREA-----EFL----KLRRDLEEAT-- 1183
Cdd:TIGR02168  558 AKKAIAFLKQNELGRVtflpldsiKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKlrkalSYLlggvLVVDDLDNALel 637
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1184 ---LQHEAMVATL----------------------------RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDL 1232
Cdd:TIGR02168  638 akkLRPGYRIVTLdgdlvrpggvitggsaktnssilerrreIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQL 717
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1233 SSSME-------SVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRS 1305
Cdd:TIGR02168  718 RKELEelsrqisALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEE 797
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1306 KQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETdAIQRTE 1385
Cdd:TIGR02168  798 LKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEE-LESELE 876
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1386 ELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERAN-SLAAALDKKQRNFDKVLAEWKTKCEES 1464
Cdd:TIGR02168  877 ALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLElRLEGLEVRIDNLQERLSEEYSLTLEEA 956
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462555497 1465 QAELEASLKESRSLSTELFKLKNAYEE-------ALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEK 1529
Cdd:TIGR02168  957 EALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEIDR 1028
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1163-1924 2.21e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.07  E-value: 2.21e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1163 ELNKKREAeflkLRRDLEEATLQHEAMVATLRKKHADsVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKS 1242
Cdd:TIGR02168  236 ELREELEE----LQEELKEAEEELEELTAELQELEEK-LEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRER 310
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1243 KANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKEsivsqlsrskqaftQQTEELKRQLEE 1322
Cdd:TIGR02168  311 LANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELE--------------AELEELESRLEE 376
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1323 ENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLaqrLQDSE 1402
Cdd:TIGR02168  377 LEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEE---LEELQ 453
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1403 EQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKtkceesQAELEAS-LKESRSLSTE 1481
Cdd:TIGR02168  454 EELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVK------ALLKNQSgLSGILGVLSE 527
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1482 LFKLKNAYEEAldqLETVKRENKNleqeiADLTEQIAENGKTIHELEKSRKQ----IELEKADIQLALEEAEAALEHEEA 1557
Cdd:TIGR02168  528 LISVDEGYEAA---IEAALGGRLQ-----AVVVENLNAAKKAIAFLKQNELGrvtfLPLDSIKGTEIQGNDREILKNIEG 599
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1558 kILRIQLELTQVKSEIDRKIA----------EKDEEIEQLKRNYQR--------------------TVETMQSALdaevr 1607
Cdd:TIGR02168  600 -FLGVAKDLVKFDPKLRKALSyllggvlvvdDLDNALELAKKLRPGyrivtldgdlvrpggvitggSAKTNSSIL----- 673
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1608 SRNEAIrlkKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVE 1687
Cdd:TIGR02168  674 ERRREI---EELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIA 750
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1688 ELRATLEQTERARKLAEQELLDSNERVQLLHTQntslihtKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMA 1767
Cdd:TIGR02168  751 QLSKELTELEAEIEELEERLEEAEEELAEAEAE-------IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLR 823
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1768 EELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEqlalkggkKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERR 1847
Cdd:TIGR02168  824 ERLESLERRIAATERRLEDLEEQIEELSEDIESLA--------AEIEELEELIEELESELEALLNERASLEEALALLRSE 895
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462555497 1848 VKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFR-KAQHELEEAEERADIAESQVNKLRAK 1924
Cdd:TIGR02168  896 LEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSeEYSLTLEEAEALENKIEDDEEEARRR 973
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1284-1924 1.47e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 109.38  E-value: 1.47e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1284 EAGELSRQLEEKESIVSQLSRSKQAFTQQT---EELKRQLE----EENKAKNALAHALQSSRHDCDLLREQYEEEQEGKA 1356
Cdd:TIGR02168  163 EAAGISKYKERRKETERKLERTRENLDRLEdilNELERQLKslerQAEKAERYKELKAELRELELALLVLRLEELREELE 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1357 ELQRALSKANSEvaqwRTKYETDAIQRTEELEEAKKK---LAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDV 1433
Cdd:TIGR02168  243 ELQEELKEAEEE----LEELTAELQELEEKLEELRLEvseLEEEIEELQKELYALANEISRLEQQKQILRERLANLERQL 318
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1434 ERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADL 1513
Cdd:TIGR02168  319 EELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASL 398
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1514 TEQIAENGKTIHELEKSRKQ--------------------------IELEKADIQLALEEAEAALEHEEAKILRIQLELT 1567
Cdd:TIGR02168  399 NNEIERLEARLERLEDRRERlqqeieellkkleeaelkelqaeleeLEEELEELQEELERLEEALEELREELEEAEQALD 478
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1568 QVKSEIDRKIAEKD--EEIEQLKRNYQRTVETM---QSALDAEVRSRNEAIRLKKKME--------GDLNEIEIQLSHAN 1634
Cdd:TIGR02168  479 AAERELAQLQARLDslERLQENLEGFSEGVKALlknQSGLSGILGVLSELISVDEGYEaaieaalgGRLQAVVVENLNAA 558
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1635 RQAAETLK-----------------------------HLRSVQGQLKD-----TQLH---------------LDDALRGQ 1665
Cdd:TIGR02168  559 KKAIAFLKqnelgrvtflpldsikgteiqgndreilkNIEGFLGVAKDlvkfdPKLRkalsyllggvlvvddLDNALELA 638
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1666 EDLKEQLAIV-------------------------ERRANL--LQAEVEELRATLEQTERARKLAEQELLDSNERVQLLH 1718
Cdd:TIGR02168  639 KKLRPGYRIVtldgdlvrpggvitggsaktnssilERRREIeeLEEKIEELEEKIAELEKALAELRKELEELEEELEQLR 718
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1719 TQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1798
Cdd:TIGR02168  719 KELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEEL 798
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1799 DEAEQlALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKS 1878
Cdd:TIGR02168  799 KALRE-ALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEA 877
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*.
gi 2462555497 1879 YKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAK 1924
Cdd:TIGR02168  878 LLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREK 923
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
845-1639 1.67e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 108.99  E-value: 1.67e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  845 ETEKEMATMKEEFQKTKDELAKSEAKRKELE------EKLVTLVQEKNDLQLQVQAESenLLDAEERCDQLIKAKFQLEA 918
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLErqaekaERYKELKAELRELELALLVLR--LEELREELEELQEELKEAEE 253
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  919 KIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKK 998
Cdd:TIGR02168  254 ELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLD 333
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  999 ALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLD 1078
Cdd:TIGR02168  334 ELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLE 413
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1079 ERLKKKDFEYCQLQSKVEDeqtlgLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVT 1158
Cdd:TIGR02168  414 DRRERLQQEIEELLKKLEE-----AELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQ 488
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1159 StQIELNKKREAEFLKLRRDLEEATLQheamvatlRKKHADSVAELGEQIdnlqRVKQKLEKEKSEF------KLEIDDL 1232
Cdd:TIGR02168  489 A-RLDSLERLQENLEGFSEGVKALLKN--------QSGLSGILGVLSELI----SVDEGYEAAIEAAlggrlqAVVVENL 555
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1233 SSSMESVSKSKANLEKIC----------RTLEDQLSEARGKNEEIQRSLSELTTQKSRLQ----------------TEAG 1286
Cdd:TIGR02168  556 NAAKKAIAFLKQNELGRVtflpldsikgTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRkalsyllggvlvvddlDNAL 635
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1287 ELSRQLEEKESIVS---QLSRSKQAFTQQTEE-----LKRQLE-EENKAKnalahalqssrhdcdlLREQYEEEQEGKAE 1357
Cdd:TIGR02168  636 ELAKKLRPGYRIVTldgDLVRPGGVITGGSAKtnssiLERRREiEELEEK----------------IEELEEKIAELEKA 699
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1358 LQrALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRlqdsEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERAN 1437
Cdd:TIGR02168  700 LA-ELRKELEELEEELEQLRKELEELSRQISALRKDLARL----EAEVEQLEERIAQLSKELTELEAEIEELEERLEEAE 774
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1438 SLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI 1517
Cdd:TIGR02168  775 EELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDI 854
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1518 AENGKTIHELEKSR--KQIELEKADIQLALEEAEAALEHEEAKILRIQL-ELTQVKSEIDRKIAEKDEEIEQLKRNYQRT 1594
Cdd:TIGR02168  855 ESLAAEIEELEELIeeLESELEALLNERASLEEALALLRSELEELSEELrELESKRSELRRELEELREKLAQLELRLEGL 934
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*....
gi 2462555497 1595 ---VETMQSALDAEVR-SRNEAIRLKKKMEGDLNEIEIQLSHANRQAAE 1639
Cdd:TIGR02168  935 evrIDNLQERLSEEYSlTLEEAEALENKIEDDEEEARRRLKRLENKIKE 983
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1166-1828 2.41e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 108.49  E-value: 2.41e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1166 KKREAEfLKLrrdleEATLQHEAMVATLRkkhadsvAELGEQIDNLQR----------VKQKL-EKEKSEFKLEIDDLSS 1234
Cdd:COG1196    173 RKEEAE-RKL-----EATEENLERLEDIL-------GELERQLEPLERqaekaeryreLKEELkELEAELLLLKLRELEA 239
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1235 SMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTE 1314
Cdd:COG1196    240 ELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLE 319
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1315 ELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRtkyetdaiqrtEELEEAKKKL 1394
Cdd:COG1196    320 ELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE-----------EELEELAEEL 388
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1395 AQRLQDSEEQveavnakcaslEKTKQRLQGEVEDLMVDVERANSLAAALDKKQrnfdkvlaewktkcEESQAELEASLKE 1474
Cdd:COG1196    389 LEALRAAAEL-----------AAQLEELEEAEEALLERLERLEEELEELEEAL--------------AELEEEEEEEEEA 443
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1475 SRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEH 1554
Cdd:COG1196    444 LEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLA 523
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1555 EEAKILRiqleltqvkseIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAevrsrneAIRLKKKMEGDLNeiEIQLSHAN 1634
Cdd:COG1196    524 GAVAVLI-----------GVEAAYEAALEAALAAALQNIVVEDDEVAAAA-------IEYLKAAKAGRAT--FLPLDKIR 583
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1635 RQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERV 1714
Cdd:COG1196    584 ARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLT 663
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1715 QLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1794
Cdd:COG1196    664 GGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLE 743
                          650       660       670
                   ....*....|....*....|....*....|....
gi 2462555497 1795 QHRLDEAEQLALKGGKKQIQKLETRIRELEFELE 1828
Cdd:COG1196    744 EEELLEEEALEELPEPPDLEELERELERLEREIE 777
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1313-1910 4.19e-23

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 107.72  E-value: 4.19e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1313 TEELKRQLEE-ENKAKNAL-AHALQSSRHDCDL---------LREQYEEEQEGKAELQRALSKANSEVAQWRTKYEtdai 1381
Cdd:COG1196    195 LGELERQLEPlERQAEKAErYRELKEELKELEAellllklreLEAELEELEAELEELEAELEELEAELAELEAELE---- 270
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1382 qrteELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKC 1461
Cdd:COG1196    271 ----ELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEEL 346
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1462 EESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADI 1541
Cdd:COG1196    347 EEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEEL 426
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1542 QLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRnYQRTVETMQSALDAEVRSRNEAIRLKKKMEG 1621
Cdd:COG1196    427 EEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAAL-LEAALAELLEELAEAAARLLLLLEAEADYEG 505
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1622 DLNE------------------IEIQLSHANRQAAETLKHLRSVQGQLKDTQlhldDALRGQEDLKEQLAivERRANLLQ 1683
Cdd:COG1196    506 FLEGvkaalllaglrglagavaVLIGVEAAYEAALEAALAAALQNIVVEDDE----VAAAAIEYLKAAKA--GRATFLPL 579
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1684 AEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDA 1763
Cdd:COG1196    580 DKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAG 659
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1764 AMMAEELKKEQDTSahLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRK 1843
Cdd:COG1196    660 GSLTGGSRRELLAA--LLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREEL 737
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462555497 1844 YERRVKELTYQSEEDRKNVLRLQDLvDKLQVKVKSYKRQ-----------AEEADEQANAHltKFRKAQHE-LEEAEER 1910
Cdd:COG1196    738 LEELLEEEELLEEEALEELPEPPDL-EELERELERLEREiealgpvnllaIEEYEELEERY--DFLSEQREdLEEARET 813
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
844-1542 9.17e-22

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 103.61  E-value: 9.17e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  844 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKndlQLQVQAESENLLDAEERCDQLIKAKF--------- 914
Cdd:TIGR02169  247 ASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEE---QLRVKEKIGELEAEIASLERSIAEKEreledaeer 323
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  915 --QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAK 992
Cdd:TIGR02169  324 laKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINE 403
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  993 LTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQekklrvdLERNKRKLEGDLKLAQESILDLEN 1072
Cdd:TIGR02169  404 LKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKK-------QEWKLEQLAADLSKYEQELYDLKE 476
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1073 DKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELqarieelEEEIEAERATRAKTEKQRSDYARELEELSERLE 1152
Cdd:TIGR02169  477 EYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVL-------KASIQGVHGTVAQLGSVGERYATAIEVAAGNRL 549
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1153 EA-----GGVTSTQIELNKKRE---AEFLKLRR---------------------DLEEATLQHEAMVA-----TLRKKHA 1198
Cdd:TIGR02169  550 NNvvvedDAVAKEAIELLKRRKagrATFLPLNKmrderrdlsilsedgvigfavDLVEFDPKYEPAFKyvfgdTLVVEDI 629
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1199 DSVAELGEQI-----------------------DNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLED 1255
Cdd:TIGR02169  630 EAARRLMGKYrmvtlegelfeksgamtggsrapRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQ 709
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1256 QLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALq 1335
Cdd:TIGR02169  710 ELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARL- 788
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1336 sSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA--QWRTKYETDAIQ----RTEELEEAKKKLAQRLQDSEEQVEAVN 1409
Cdd:TIGR02169  789 -SHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNrlTLEKEYLEKEIQelqeQRIDLKEQIKSIEKEIENLNGKKEELE 867
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1410 AKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAY 1489
Cdd:TIGR02169  868 EELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIP 947
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1490 EEALDqLETVKRENKNLEQEIADL-------TEQIAENGKTIHELEKSRKQIELEKADIQ 1542
Cdd:TIGR02169  948 EEELS-LEDVQAELQRVEEEIRALepvnmlaIQEYEEVLKRLDELKEKRAKLEEERKAIL 1006
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1201-1910 3.49e-21

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 101.68  E-value: 3.49e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1201 VAELGEQIDNLQRVKQKLEK------EKSEFKL-----EIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQR 1269
Cdd:TIGR02169  193 IDEKRQQLERLRREREKAERyqallkEKREYEGyellkEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQ 272
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1270 SLSELTTQKSRL-QTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEenkaknalahaLQSSRHDCDLLREQY 1348
Cdd:TIGR02169  273 LLEELNKKIKDLgEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAK-----------LEAEIDKLLAEIEEL 341
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1349 EEEQEGKAELQRALSkanSEVAQWRTKYEtDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVED 1428
Cdd:TIGR02169  342 EREIEEERKRRDKLT---EEYAELKEELE-DLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQR 417
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1429 LMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQ 1508
Cdd:TIGR02169  418 LSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEA 497
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1509 EIADLTEQIAENGKTIHELEKSRK----------------QIELEKAD--------IQLALEEAEAALEHEEAKILR--- 1561
Cdd:TIGR02169  498 QARASEERVRGGRAVEEVLKASIQgvhgtvaqlgsvgeryATAIEVAAgnrlnnvvVEDDAVAKEAIELLKRRKAGRatf 577
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1562 IQLELTQVKSEIDRKIAEK------------DEEIEQ-LKRNYQRT--VETMQSA-----------LDAEV--------- 1606
Cdd:TIGR02169  578 LPLNKMRDERRDLSILSEDgvigfavdlvefDPKYEPaFKYVFGDTlvVEDIEAArrlmgkyrmvtLEGELfeksgamtg 657
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1607 --RSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQA 1684
Cdd:TIGR02169  658 gsRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKE 737
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1685 EVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLmqLQSEVEDASRDARNAEEKAKKAITDAA 1764
Cdd:TIGR02169  738 RLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARL--SHSRIPEIQAELSKLEEEVSRIEARLR 815
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1765 MMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE--AEQLALKGGKK----QIQKLETRIRELEFELEGEQKKNTESV 1838
Cdd:TIGR02169  816 EIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSieKEIENLNGKKEeleeELEELEAALRDLESRLGDLKKERDELE 895
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462555497 1839 KGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEaDEQANAHLTKFRKAQHELEEAEER 1910
Cdd:TIGR02169  896 AQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGE-DEEIPEEELSLEDVQAELQRVEEE 966
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
866-1423 4.37e-21

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 101.17  E-value: 4.37e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  866 KSEAKRKELEEklvtLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLE 945
Cdd:COG1196    219 KEELKELEAEL----LLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELL 294
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  946 DECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTK 1025
Cdd:COG1196    295 AELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1026 SKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQF 1105
Cdd:COG1196    375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL 454
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1106 QKKIKELQARIEELEEEIEAE----RATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEE 1181
Cdd:COG1196    455 EEEEEALLELLAELLEEAALLeaalAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEA 534
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1182 A--TLQHEAMVATLRKKHADSVAELGEQIDNLqrvKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKIcRTLEDQLSE 1259
Cdd:COG1196    535 AyeAALEAALAAALQNIVVEDDEVAAAAIEYL---KAAKAGRATFLPLDKIRARAALAAALARGAIGAAV-DLVASDLRE 610
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1260 ARGKNEEIQRSLSELTTQKSRLQTeAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRH 1339
Cdd:COG1196    611 ADARYYVLGDTLLGRTLVAARLEA-ALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLA 689
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1340 DcdlLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTK 1419
Cdd:COG1196    690 E---EELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELE 766

                   ....
gi 2462555497 1420 QRLQ 1423
Cdd:COG1196    767 RELE 770
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1388-1922 2.90e-20

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 98.47  E-value: 2.90e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1388 EEAKKKLAQ------RLQDSEEQVEAvnaKCASLEK------TKQRLQGEVEDLmvdveRANSLAAALD---KKQRNFDK 1452
Cdd:COG1196    175 EEAERKLEAteenleRLEDILGELER---QLEPLERqaekaeRYRELKEELKEL-----EAELLLLKLReleAELEELEA 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1453 VLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRK 1532
Cdd:COG1196    247 ELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELA 326
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1533 QIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEA 1612
Cdd:COG1196    327 ELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELE 406
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1613 IRL------KKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEV 1686
Cdd:COG1196    407 EAEeallerLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEEL 486
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1687 EELRATLEQTERARKLAEQEL-----LDSNERVQLLHTQNTSLIHTKKKLETDL-----MQLQSEVEDASRDARNAEEKA 1756
Cdd:COG1196    487 AEAAARLLLLLEAEADYEGFLegvkaALLLAGLRGLAGAVAVLIGVEAAYEAALeaalaAALQNIVVEDDEVAAAAIEYL 566
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1757 KKA-------ITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL---------DEAEQLALKGGKKQIQKLETRI 1820
Cdd:COG1196    567 KAAkagratfLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYyvlgdtllgRTLVAARLEAALRRAVTLAGRL 646
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1821 RELEFELEGEQkkntesvKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKA 1900
Cdd:COG1196    647 REVTLEGEGGS-------AGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEE 719
                          570       580
                   ....*....|....*....|..
gi 2462555497 1901 QHELEEAEERADIAESQVNKLR 1922
Cdd:COG1196    720 ELEEEALEEQLEAEREELLEEL 741
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1002-1802 1.17e-19

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 96.34  E-value: 1.17e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1002 EAHQQALDDLQAEEDKVNSLN-KTKSKLEQQVEDLESSLEQ---EKKLRVDLERNKRKLEGDLKlaqesildlendkQQL 1077
Cdd:pfam15921   81 EEYSHQVKDLQRRLNESNELHeKQKFYLRQSVIDLQTKLQEmqmERDAMADIRRRESQSQEDLR-------------NQL 147
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1078 DERLKKKDFEYCQLQSKVEDEQTlglqfqkKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGV 1157
Cdd:pfam15921  148 QNTVHELEAAKCLKEDMLEDSNT-------QIEQLRKMMLSHEGVLQEIRSILVDFEEASGKKIYEHDSMSTMHFRSLGS 220
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1158 TSTQIELNKKREAEFLKLRrdleeaTLQHEAMVATLRKKHADSVAELgeqidnLQRVKQKLEKEKSEFKLEIDDLSSSME 1237
Cdd:pfam15921  221 AISKILRELDTEISYLKGR------IFPVEDQLEALKSESQNKIELL------LQQHQDRIEQLISEHEVEITGLTEKAS 288
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1238 SVSKSKANLEKICRTLEDQlseARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEK-ESIVSQLSRSKQAFTQQTEEL 1316
Cdd:pfam15921  289 SARSQANSIQSQLEIIQEQ---ARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKiEELEKQLVLANSELTEARTER 365
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1317 KRQLEEENKAKNALAHAL---QSSRHDCDLLREQYE---EEQEGKA----ELQRALSKANSEVaqwrtkyetdaiQRTEE 1386
Cdd:pfam15921  366 DQFSQESGNLDDQLQKLLadlHKREKELSLEKEQNKrlwDRDTGNSitidHLRRELDDRNMEV------------QRLEA 433
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1387 LEEAKKKLAQ--------RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDL------MVDVERANS-LAAALDKKQRNFD 1451
Cdd:pfam15921  434 LLKAMKSECQgqmerqmaAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELtakkmtLESSERTVSdLTASLQEKERAIE 513
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1452 KVLAEwktkCEESQAELEASLKESRSLSTELFKLKNAYEE--ALD-QLETVKRENKNLEQEIADLTEQIAENGKTIHELE 1528
Cdd:pfam15921  514 ATNAE----ITKLRSRVDLKLQELQHLKNEGDHLRNVQTEceALKlQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQ 589
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1529 KSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ-----LELTQVK-----SEIDRKIAEKDEEIEQLKRNYQRTVETM 1598
Cdd:pfam15921  590 VEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEarvsdLELEKVKlvnagSERLRAVKDIKQERDQLLNEVKTSRNEL 669
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1599 QS-ALDAEVRSRNeaIRLK-KKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGqlkdTQLHlddALRGQEDLKEQLAIVE 1676
Cdd:pfam15921  670 NSlSEDYEVLKRN--FRNKsEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEG----SDGH---AMKVAMGMQKQITAKR 740
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1677 RRANLLQAEVEELRATLEQTERARKLAEQElldSNERVQLLHTQNTSlihtKKKLETDLMQLQSEVEDASRDARNAEEKA 1756
Cdd:pfam15921  741 GQIDALQSKIQFLEEAMTNANKEKHFLKEE---KNKLSQELSTVATE----KNKMAGELEVLRSQERRLKEKVANMEVAL 813
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*.
gi 2462555497 1757 KKAITDAAMMAEELKKEQDTSAHLErmkknleqtvkdLQHRLDEAE 1802
Cdd:pfam15921  814 DKASLQFAECQDIIQRQEQESVRLK------------LQHTLDVKE 847
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
1275-1932 1.15e-18

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 93.32  E-value: 1.15e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1275 TTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEElkrqleeenkaKNALAHALQSSRHDCDLLREQYEEEQEG 1354
Cdd:pfam01576    1 TRQEEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEE-----------KNALQEQLQAETELCAEAEEMRARLAAR 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1355 KAELQRALSKANSEVAQWRtkyetdaiQRTEELEEAKKKLAQRLQDSEEQVEAVnakcaslEKTKQRLQGEVEDLMVDVE 1434
Cdd:pfam01576   70 KQELEEILHELESRLEEEE--------ERSQQLQNEKKKMQQHIQDLEEQLDEE-------EAARQKLQLEKVTTEAKIK 134
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1435 RANSLAAALDKKQRNFDKVlaewKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLET-VKRENK--------- 1504
Cdd:pfam01576  135 KLEEDILLLEDQNSKLSKE----RKLLEERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEErLKKEEKgrqelekak 210
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1505 -NLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKdEE 1583
Cdd:pfam01576  211 rKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQEDLESERAAR-NK 289
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1584 IEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQ-LKDTQLHLDDAL 1662
Cdd:pfam01576  290 AEKQRRDLGEELEALKTELEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQKHTQaLEELTEQLEQAK 369
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1663 RGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELldsnervQLLHTQNTSLIHTKKKLETDLMQLQSEV 1742
Cdd:pfam01576  370 RNKANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEGQL-------QELQARLSESERQRAELAEKLSKLQSEL 442
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1743 EDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKD-------LQHRLDEAEQlALKGGKKQIQK 1815
Cdd:pfam01576  443 ESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQledernsLQEQLEEEEE-AKRNVERQLST 521
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1816 LETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEED-------RKNVLRLQDLVDKLQVKVKSYK-------- 1880
Cdd:pfam01576  522 LQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKaaaydklEKTKNRLQQELDDLLVDLDHQRqlvsnlek 601
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462555497 1881 -----------------RQAEE---ADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSR 1932
Cdd:pfam01576  602 kqkkfdqmlaeekaisaRYAEErdrAEAEAREKETRALSLARALEEALEAKEELERTNKQLRAEMEDLVSSK 673
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
841-1701 2.26e-18

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 92.44  E-value: 2.26e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  841 LKSAETEKEMAtmkEEFQKTKDELAKSEAKrkELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKI 920
Cdd:TIGR02169  200 LERLRREREKA---ERYQALLKEKREYEGY--ELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLL 274
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  921 KEVTERAEDE-EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKA 999
Cdd:TIGR02169  275 EELNKKIKDLgEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDK 354
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1000 LQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDE 1079
Cdd:TIGR02169  355 LTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEA 434
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1080 RLKkkdfeycQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSD----YARELEELSERLEEAG 1155
Cdd:TIGR02169  435 KIN-------ELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKlqreLAEAEAQARASEERVR 507
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1156 GVTSTQIELNKKREAeFLKLRRDLEEATLQHEAMVATLRKKHA-------DSVAElgEQIDNLQRVKQ------KLEKEK 1222
Cdd:TIGR02169  508 GGRAVEEVLKASIQG-VHGTVAQLGSVGERYATAIEVAAGNRLnnvvvedDAVAK--EAIELLKRRKAgratflPLNKMR 584
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1223 SEFKleidDLSSSMESVSKSKA-NLEKICRTLEDQLSEARG-----KNEEIQRSLseltTQKSRLQTEAGELsrqLEEKE 1296
Cdd:TIGR02169  585 DERR----DLSILSEDGVIGFAvDLVEFDPKYEPAFKYVFGdtlvvEDIEAARRL----MGKYRMVTLEGEL---FEKSG 653
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1297 SIV--SQLSRSKQAFT-QQTEELKRQLEEENKAKNALAhalqssrhdcDLLREQYEEEQEGKaELQRALSKANSEVAqwr 1373
Cdd:TIGR02169  654 AMTggSRAPRGGILFSrSEPAELQRLRERLEGLKRELS----------SLQSELRRIENRLD-ELSQELSDASRKIG--- 719
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1374 tkyetDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMvdvERANSLAAALDKKQRNFDKv 1453
Cdd:TIGR02169  720 -----EIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELE---EDLHKLEEALNDLEARLSH- 790
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1454 laewkTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQ 1533
Cdd:TIGR02169  791 -----SRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEE 865
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1534 IELEKADIQLALEEAEAALEHEEAKILRIQLELtqvkSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAI 1613
Cdd:TIGR02169  866 LEEELEELEAALRDLESRLGDLKKERDELEAQL----RELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKG 941
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1614 RLKKKMEGDLNEIEIQlshANRQAAET-LKHLRSVQGQLKDtqlHLDDALRGQEDLKEQLAIverranlLQAEVEELRAT 1692
Cdd:TIGR02169  942 EDEEIPEEELSLEDVQ---AELQRVEEeIRALEPVNMLAIQ---EYEEVLKRLDELKEKRAK-------LEEERKAILER 1008

                   ....*....
gi 2462555497 1693 LEQTERARK 1701
Cdd:TIGR02169 1009 IEEYEKKKR 1017
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1247-1924 3.40e-18

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 91.67  E-value: 3.40e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1247 EKICRTLEDqLSEARGKNEEIQRSLSELTTQKSRLQTEAG------ELSRQLEEKE-----SIVSQLSRSKQAFTQQTEE 1315
Cdd:TIGR02169  170 RKKEKALEE-LEEVEENIERLDLIIDEKRQQLERLRREREkaeryqALLKEKREYEgyellKEKEALERQKEAIERQLAS 248
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1316 LKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKA-ELQRALSKANSEVAQWRtkyetDAIqrtEELEEAKKKL 1394
Cdd:TIGR02169  249 LEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQlRVKEKIGELEAEIASLE-----RSI---AEKERELEDA 320
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1395 AQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKE 1474
Cdd:TIGR02169  321 EERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKRE 400
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1475 SRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAaleh 1554
Cdd:TIGR02169  401 INELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKE---- 476
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1555 eeaKILRIQLELTQVKSEIDRKIAEKDE---------------------------EIEQLKRNYQRTVETMQSA-LDAEV 1606
Cdd:TIGR02169  477 ---EYDRVEKELSKLQRELAEAEAQARAseervrggraveevlkasiqgvhgtvaQLGSVGERYATAIEVAAGNrLNNVV 553
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1607 RSRN----EAIRLKKKMEG-------------------------------DLNEIEIQLSHANRQA------AETLKHLR 1645
Cdd:TIGR02169  554 VEDDavakEAIELLKRRKAgratflplnkmrderrdlsilsedgvigfavDLVEFDPKYEPAFKYVfgdtlvVEDIEAAR 633
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1646 SVQGQLKDTQLHLD------------DALRGQE----DLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLD 1709
Cdd:TIGR02169  634 RLMGKYRMVTLEGElfeksgamtggsRAPRGGIlfsrSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSD 713
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1710 SNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMkknleq 1789
Cdd:TIGR02169  714 ASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEAR------ 787
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1790 tvkDLQHRLDEAEQLALKgGKKQIQKLETRIRELE-------FELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNV 1862
Cdd:TIGR02169  788 ---LSHSRIPEIQAELSK-LEEEVSRIEARLREIEqklnrltLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKK 863
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462555497 1863 LRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAK 1924
Cdd:TIGR02169  864 EELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAK 925
PTZ00121 PTZ00121
MAEBL; Provisional
831-1435 4.64e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 91.74  E-value: 4.64e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  831 MKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDlQLQVQAEsENLLDAEERCDQLI 910
Cdd:PTZ00121  1262 MAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKAD-EAKKKAE-EAKKKADAAKKKAE 1339
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  911 KAKFQLEAKIKEvTERAEDEEEINAEltaKKRKLEDECSELKKDIDDLEltlAKVEKEKHATENKVKnlTEELSGLDETI 990
Cdd:PTZ00121  1340 EAKKAAEAAKAE-AEAAADEAEAAEE---KAEAAEKKKEEAKKKADAAK---KKAEEKKKADEAKKK--AEEDKKKADEL 1410
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  991 AKLTREKKALQEAHQQALDDLQAEEdkvnslNKTKSKLEQQVEDLESSLEQEKKlrvdLERNKRKLEgDLKLAQESILDL 1070
Cdd:PTZ00121  1411 KKAAAAKKKADEAKKKAEEKKKADE------AKKKAEEAKKADEAKKKAEEAKK----AEEAKKKAE-EAKKADEAKKKA 1479
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1071 ENDKQQldERLKKKDFEycqlQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEaeratRAKTEKQRSDYARELEELSER 1150
Cdd:PTZ00121  1480 EEAKKA--DEAKKKAEE----AKKKADEAKKAAEAKKKADEAKKAEEAKKADEA-----KKAEEAKKADEAKKAEEKKKA 1548
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1151 LeeaggvtstqiELNKKREAEFLKLRRDLEEATLQHEAMVATLRKkhadsvAELGEQIdnlqrvkqklEKEKSEFKLEID 1230
Cdd:PTZ00121  1549 D-----------ELKKAEELKKAEEKKKAEEAKKAEEDKNMALRK------AEEAKKA----------EEARIEEVMKLY 1601
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1231 DLSSSMESVSKSKANLEKIcrtledqLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFT 1310
Cdd:PTZ00121  1602 EEEKKMKAEEAKKAEEAKI-------KAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDK 1674
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1311 QQTEELKRQLEEENKAKNALAHALQSSRhDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAiQRTEEL--- 1387
Cdd:PTZ00121  1675 KKAEEAKKAEEDEKKAAEALKKEAEEAK-KAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDK-KKAEEAkkd 1752
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*...
gi 2462555497 1388 EEAKKKLAQRLQDSEEQVEAVNAKCASLekTKQRLQGEVEDLMVDVER 1435
Cdd:PTZ00121  1753 EEEKKKIAHLKKEEEKKAEEIRKEKEAV--IEEELDEEDEKRRMEVDK 1798
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
918-1804 9.14e-18

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 90.51  E-value: 9.14e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  918 AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKdIDDLELTLAKVE-----KEKHATENKVKNLTEELSGLDETIAK 992
Cdd:TIGR02169  177 EELEEVEENIERLDLIIDEKRQQLERLRREREKAER-YQALLKEKREYEgyellKEKEALERQKEAIERQLASLEEELEK 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  993 LTREKKALQEAHQQALDDLQAEEDKVNSLNKTKS-KLEQQVEDLESSLEQekklrvdlernkrkLEGDLKLAQESILDLE 1071
Cdd:TIGR02169  256 LTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQlRVKEKIGELEAEIAS--------------LERSIAEKERELEDAE 321
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1072 NDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERL 1151
Cdd:TIGR02169  322 ERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREI 401
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1152 EEAGGVTSTQIELNKKREAEFLKLRRDLEEAtlqhEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEfkleidd 1231
Cdd:TIGR02169  402 NELKRELDRLQEELQRLSEELADLNAAIAGI----EAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQE------- 470
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1232 lsssmesvsksKANLEKICRTLEDQLSEArgkneeiQRSLSELTTQKSRLQTEAGELSRQLEEKES-------IVSQLSR 1304
Cdd:TIGR02169  471 -----------LYDLKEEYDRVEKELSKL-------QRELAEAEAQARASEERVRGGRAVEEVLKAsiqgvhgTVAQLGS 532
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1305 SKQAFTQQTEELKRQ------LEEENKAKNA--LAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKY 1376
Cdd:TIGR02169  533 VGERYATAIEVAAGNrlnnvvVEDDAVAKEAieLLKRRKAGRATFLPLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKY 612
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1377 ETD---AIQRT---EELEEAKKKLAQ-RLQDSE-EQVEAVNA------KCASLEKTKQRLQGEVEDLMVDVERANSLAAA 1442
Cdd:TIGR02169  613 EPAfkyVFGDTlvvEDIEAARRLMGKyRMVTLEgELFEKSGAmtggsrAPRGGILFSRSEPAELQRLRERLEGLKRELSS 692
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1443 LDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGK 1522
Cdd:TIGR02169  693 LQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEE 772
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1523 TIHELEKSRKQIELEKADiqlaleeaeaaleheeAKILRIQLELTQVKSEIdRKIAEKDEEIEQLKRNYQRTVETMQSAL 1602
Cdd:TIGR02169  773 DLHKLEEALNDLEARLSH----------------SRIPEIQAELSKLEEEV-SRIEARLREIEQKLNRLTLEKEYLEKEI 835
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1603 DAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQlhlddalRGQEDLKEQLAIVERRANLL 1682
Cdd:TIGR02169  836 QELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLK-------KERDELEAQLRELERKIEEL 908
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1683 QAEVEELRATLEQTERARKLAEQEL--LDSNERVQLLHTQNtslihtkkklETDLMQLQSEVEDASRDARNAEEKAKKAI 1760
Cdd:TIGR02169  909 EAQIEKKRKRLSELKAKLEALEEELseIEDPKGEDEEIPEE----------ELSLEDVQAELQRVEEEIRALEPVNMLAI 978
                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....
gi 2462555497 1761 tdaammaEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1804
Cdd:TIGR02169  979 -------QEYEEVLKRLDELKEKRAKLEEERKAILERIEEYEKK 1015
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
844-1579 2.04e-17

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 89.36  E-value: 2.04e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  844 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKND--------------------------------LQLQ 891
Cdd:TIGR02169  166 AEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKaeryqallkekreyegyellkekealerqkeaIERQ 245
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  892 VQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAED--EEEIN------AELTAKKRKLEDECSELKKDIDDLELTLA 963
Cdd:TIGR02169  246 LASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDlgEEEQLrvkekiGELEAEIASLERSIAEKERELEDAEERLA 325
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  964 KVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEE-------DKVNSLNKTKSKLEQQVEDLE 1036
Cdd:TIGR02169  326 KLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDkefaetrDELKDYREKLEKLKREINELK 405
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1037 SSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARI 1116
Cdd:TIGR02169  406 RELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKEL 485
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1117 EELEEEIEAERATRAKTEKQRSDYARELEELSERLeeaGGVTSTQIELNKKREA-------------------------- 1170
Cdd:TIGR02169  486 SKLQRELAEAEAQARASEERVRGGRAVEEVLKASI---QGVHGTVAQLGSVGERyataievaagnrlnnvvveddavake 562
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1171 --EFLKlRRDLEEATL-------QHEAMVATLRKKHADSVA----ELGEQIDNLQR-------VKQKLEKEKS---EFKL 1227
Cdd:TIGR02169  563 aiELLK-RRKAGRATFlplnkmrDERRDLSILSEDGVIGFAvdlvEFDPKYEPAFKyvfgdtlVVEDIEAARRlmgKYRM 641
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1228 -----EIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQL 1302
Cdd:TIGR02169  642 vtlegELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEI 721
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1303 SRSKQAFTQQTEELKRQLEEenkaknalahalqssrhdcdlLREQYEEEQEGKAELQRALSKANSEVAQwrtkYETDAIQ 1382
Cdd:TIGR02169  722 EKEIEQLEQEEEKLKERLEE---------------------LEEDLSSLEQEIENVKSELKELEARIEE----LEEDLHK 776
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1383 RTEELEEAKKKLAQrlqdseEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCE 1462
Cdd:TIGR02169  777 LEEALNDLEARLSH------SRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIK 850
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1463 ESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIElEKADIQ 1542
Cdd:TIGR02169  851 SIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELK-AKLEAL 929
                          810       820       830
                   ....*....|....*....|....*....|....*..
gi 2462555497 1543 LALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAE 1579
Cdd:TIGR02169  930 EEELSEIEDPKGEDEEIPEEELSLEDVQAELQRVEEE 966
PTZ00121 PTZ00121
MAEBL; Provisional
1258-1912 4.50e-17

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 88.27  E-value: 4.50e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1258 SEARGKNEEIQRSLSELTTQKSRLQ--TEAGELSRQLEE--KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNAL--- 1330
Cdd:PTZ00121  1094 EEAFGKAEEAKKTETGKAEEARKAEeaKKKAEDARKAEEarKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARkae 1173
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1331 -AHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYE----TDAIQRTEEL----EEAKKKLAQR---- 1397
Cdd:PTZ00121  1174 dAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEdakkAEAVKKAEEAkkdaEEAKKAEEERnnee 1253
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1398 LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRS 1477
Cdd:PTZ00121  1254 IRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADA 1333
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1478 LSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKS----RKQIELEK-ADIQLALEEAEAAL 1552
Cdd:PTZ00121  1334 AKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKaeekKKADEAKKkAEEDKKKADELKKA 1413
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1553 EHEEAKILRIQLELTQV-KSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLS 1631
Cdd:PTZ00121  1414 AAAKKKADEAKKKAEEKkKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAE 1493
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1632 HANRQAAETLKhlrSVQGQLKDTQLHLDDALRGQEDLK---EQLAIVERRANLLQAEVEELRAT--LEQTERARKlAEQE 1706
Cdd:PTZ00121  1494 EAKKKADEAKK---AAEAKKKADEAKKAEEAKKADEAKkaeEAKKADEAKKAEEKKKADELKKAeeLKKAEEKKK-AEEA 1569
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1707 LLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAitdaammaEELKKEQDTSAHLERMKKN 1786
Cdd:PTZ00121  1570 KKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKA--------EELKKAEEEKKKVEQLKKK 1641
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1787 LEQTVKDLQH-RLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRL 1865
Cdd:PTZ00121  1642 EAEEKKKAEElKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEEL 1721
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1866 QDLVDKLQVKVKSYKRQAEEAD---EQANAHLTKFRKAQHELEEAEERAD 1912
Cdd:PTZ00121  1722 KKAEEENKIKAEEAKKEAEEDKkkaEEAKKDEEEKKKIAHLKKEEEKKAE 1771
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
973-1591 6.36e-17

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 87.00  E-value: 6.36e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  973 ENKVKNLTEELSGLDETIAKLTREKKALQeahqqalDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERN 1052
Cdd:TIGR04523   32 DTEEKQLEKKLKTIKNELKNKEKELKNLD-------KNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSD 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1053 KRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAK 1132
Cdd:TIGR04523  105 LSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLN 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1133 TEKQRSDyareleelserleeaggvtstqieLNKKREAEFLKLrrdleeatlqheAMVATLRKKHAdsvaELGEQIDNLQ 1212
Cdd:TIGR04523  185 IQKNIDK------------------------IKNKLLKLELLL------------SNLKKKIQKNK----SLESQISELK 224
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1213 RVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQL 1292
Cdd:TIGR04523  225 KQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQK 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1293 EEkeSIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQW 1372
Cdd:TIGR04523  305 EQ--DWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSY 382
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1373 RtkyetdaiQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDK 1452
Cdd:TIGR04523  383 K--------QEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKEL 454
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1453 VLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRK 1532
Cdd:TIGR04523  455 IIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKK 534
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462555497 1533 QIELEKADIQlaleeaeaaleheeAKILRIQLELTqvKSEIDRKIAEKDEEIEQLKRNY 1591
Cdd:TIGR04523  535 EKESKISDLE--------------DELNKDDFELK--KENLEKEIDEKNKEIEELKQTQ 577
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1209-1906 3.74e-16

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 85.02  E-value: 3.74e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1209 DNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLsELTTQKSRLQTEAGEL 1288
Cdd:TIGR00618  187 AKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKR-EAQEEQLKKQQLLKQL 265
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1289 SRQLEEKESIVSQLSRSKQAFTQQTEELK-----RQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS 1363
Cdd:TIGR00618  266 RARIEELRAQEAVLEETQERINRARKAAPlaahiKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRR 345
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1364 KANSEVAQW-RTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVedlmvdveranSLAAA 1442
Cdd:TIGR00618  346 LLQTLHSQEiHIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQ-----------ATIDT 414
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1443 LDKKQRNFDKVLAEWKTKCEESQAELEaslkESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGK 1522
Cdd:TIGR00618  415 RTSAFRDLQGQLAHAKKQQELQQRYAE----LCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKA 490
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1523 TIHE--LEKSRKQIELEKADIQ-LALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKR---NYQRTVE 1596
Cdd:TIGR00618  491 VVLArlLELQEEPCPLCGSCIHpNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASlkeQMQEIQQ 570
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1597 TMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVE 1676
Cdd:TIGR00618  571 SFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHA 650
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1677 RRANLLQAEVEE-LRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKL---ETDLMQLQSEVEDASRDARNA 1752
Cdd:TIGR00618  651 LQLTLTQERVREhALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLrelETHIEEYDREFNEIENASSSL 730
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1753 EEKAKKAITDAAMMAEELKKEQDTS-AHLERMKKNLEQTVKDLQHRLDEAEQLalkggkkqIQKLETRIRELEfELEGEQ 1831
Cdd:TIGR00618  731 GSDLAAREDALNQSLKELMHQARTVlKARTEAHFNNNEEVTAALQTGAELSHL--------AAEIQFFNRLRE-EDTHLL 801
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462555497 1832 KKNTESVKGLRKYERRVKELT-YQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQaNAHLTKFRKAQHELEE 1906
Cdd:TIGR00618  802 KTLEAEIGQEIPSDEDILNLQcETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQ-LAQLTQEQAKIIQLSD 876
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1301-1906 4.31e-16

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 84.78  E-value: 4.31e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1301 QLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVaqwrtkyeTDA 1380
Cdd:pfam15921   75 HIERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDL--------RNQ 146
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1381 IQRT-EELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQrlqgEVEDLMVDVERAN----------------SLAAAL 1443
Cdd:pfam15921  147 LQNTvHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQ----EIRSILVDFEEASgkkiyehdsmstmhfrSLGSAI 222
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1444 DKKQRNFDKVLAEWKTKC-----------EESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIAD 1512
Cdd:pfam15921  223 SKILRELDTEISYLKGRIfpvedqlealkSESQNKIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQSQLE 302
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1513 LTEQIAENGKTIH-----ELEKSRKQIeleKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEK---DEEI 1584
Cdd:pfam15921  303 IIQEQARNQNSMYmrqlsDLESTVSQL---RSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQESgnlDDQL 379
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1585 EQL-----KRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHAnrqaaeTLKHLRS-VQGQLKDTQLHL 1658
Cdd:pfam15921  380 QKLladlhKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEA------LLKAMKSeCQGQMERQMAAI 453
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1659 DDALRGQEDLKEQLAIVERRANLLQAEVEELRA---TLEQTERARKLAEQELldsNERVQLLHTQNTSLIHTKKKLETDL 1735
Cdd:pfam15921  454 QGKNESLEKVSSLTAQLESTKEMLRKVVEELTAkkmTLESSERTVSDLTASL---QEKERAIEATNAEITKLRSRVDLKL 530
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1736 MQLQ--SEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQD-----------TSAHLERMKKNLEQTVKDLQHRLDEAE 1802
Cdd:pfam15921  531 QELQhlKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIEnmtqlvgqhgrTAGAMQVEKAQLEKEINDRRLELQEFK 610
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1803 QLALKGGKKqIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNvlrLQDLVDKLQVKVKSYKRQ 1882
Cdd:pfam15921  611 ILKDKKDAK-IRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNE---LNSLSEDYEVLKRNFRNK 686
                          650       660
                   ....*....|....*....|....
gi 2462555497 1883 AEEADEQANAHLTKFRKAQHELEE 1906
Cdd:pfam15921  687 SEEMETTTNKLKMQLKSAQSELEQ 710
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1109-1733 4.67e-16

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 84.60  E-value: 4.67e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1109 IKELQARIeeleeeieaeratrAKTEKQRSD---YAREleelserleeaggvtstQIELnKKREAEFLKLRRDLEEATLQ 1185
Cdd:COG1196    195 LGELERQL--------------EPLERQAEKaerYREL-----------------KEEL-KELEAELLLLKLRELEAELE 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1186 heaMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNE 1265
Cdd:COG1196    243 ---ELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLE 319
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1266 EIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLR 1345
Cdd:COG1196    320 ELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELA 399
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1346 EQYEEEQEGKAELQRALSKANSEVAQWRTKyETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGE 1425
Cdd:COG1196    400 AQLEELEEAEEALLERLERLEEELEELEEA-LAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAA 478
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1426 VEDLMVDVERANSLAAALDKKQRNFDKVLAEWKtkceesQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKN 1505
Cdd:COG1196    479 LAELLEELAEAAARLLLLLEAEADYEGFLEGVK------AALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIV 552
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1506 LEQEiADLTEQIAENGK------TIHELEKSRKQIELEKADIQLALEE---AEAALEHEEAKILRIQLELTQVKSEIDRK 1576
Cdd:COG1196    553 VEDD-EVAAAAIEYLKAakagraTFLPLDKIRARAALAAALARGAIGAavdLVASDLREADARYYVLGDTLLGRTLVAAR 631
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1577 IAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL 1656
Cdd:COG1196    632 LEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAE 711
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1657 HLDDALRGQ---EDLKEQLAIVERRANLLQAE------------------VEELRATLEQTERARK-------LAEQELL 1708
Cdd:COG1196    712 AEEERLEEEleeEALEEQLEAEREELLEELLEeeelleeealeelpeppdLEELERELERLEREIEalgpvnlLAIEEYE 791
                          650       660
                   ....*....|....*....|....*
gi 2462555497 1709 DSNERVQLLHTQNTSLIHTKKKLET 1733
Cdd:COG1196    792 ELEERYDFLSEQREDLEEARETLEE 816
PTZ00121 PTZ00121
MAEBL; Provisional
836-1526 6.60e-16

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 84.42  E-value: 6.60e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  836 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQlqvQAESENLLDAEERCDQlIKAKFQ 915
Cdd:PTZ00121  1165 KAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEAR---KAEDAKKAEAVKKAEE-AKKDAE 1240
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  916 LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLElTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTR 995
Cdd:PTZ00121  1241 EAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELK-KAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADE 1319
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  996 EKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEgDLKLAQESILDLENDKQ 1075
Cdd:PTZ00121  1320 AKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKAD-AAKKKAEEKKKADEAKK 1398
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1076 QLDERLKKKDfeycqLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAG 1155
Cdd:PTZ00121  1399 KAEEDKKKAD-----ELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKAD 1473
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1156 gvtstqiELNKKREAeflklRRDLEEATLQHEAMvatlrKKHADSVAELGEQIDNLQRVKQKLEKEKSEfklEIDDLSSS 1235
Cdd:PTZ00121  1474 -------EAKKKAEE-----AKKADEAKKKAEEA-----KKKADEAKKAAEAKKKADEAKKAEEAKKAD---EAKKAEEA 1533
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1236 MESVSKSKAnlEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSR-LQTEAGELSRQLEEKEsIVSQLSRSKQAFTQQTE 1314
Cdd:PTZ00121  1534 KKADEAKKA--EEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKnMALRKAEEAKKAEEAR-IEEVMKLYEEEKKMKAE 1610
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1315 ELKRqlEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAiQRTEEL---EEAK 1391
Cdd:PTZ00121  1611 EAKK--AEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDK-KKAEEAkkaEEDE 1687
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1392 KKLAQRLQDSEEQ---VEAVNAKCASLEKTKQRLQGEVEDLMVDVERAnslaaaldKKQRNFDKVLAEWKTKCEESQAEL 1468
Cdd:PTZ00121  1688 KKAAEALKKEAEEakkAEELKKKEAEEKKKAEELKKAEEENKIKAEEA--------KKEAEEDKKKAEEAKKDEEEKKKI 1759
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462555497 1469 EASLKESRSLSTELFKLKNAYEEaldqlETVKRENKNLEQEIADLTEQIAENGKTIHE 1526
Cdd:PTZ00121  1760 AHLKKEEEKKAEEIRKEKEAVIE-----EELDEEDEKRRMEVDKKIKDIFDNFANIIE 1812
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
964-1864 8.66e-16

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 83.87  E-value: 8.66e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  964 KVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAhqqalDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEK 1043
Cdd:pfam02463  143 KIEIIAMMKPERRLEIEEEAAGSRLKRKKKEALKKLIEET-----ENLAELIIDLEELKLQELKLKEQAKKALEYYQLKE 217
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1044 KLRvdLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEI 1123
Cdd:pfam02463  218 KLE--LEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEE 295
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1124 EAERATRAKTEKQRSDYARELEELSERLEEAggvtSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAE 1203
Cdd:pfam02463  296 EELKSELLKLERRKVDDEEKLKESEKEKKKA----EKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQL 371
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1204 LGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT 1283
Cdd:pfam02463  372 EEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKE 451
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1284 EAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALS 1363
Cdd:pfam02463  452 ELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRL 531
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1364 KANSEVAQwrtKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAAL 1443
Cdd:pfam02463  532 GDLGVAVE---NYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQL 608
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1444 DKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKT 1523
Cdd:pfam02463  609 DKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESE 688
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1524 IHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALD 1603
Cdd:pfam02463  689 LAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSE 768
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1604 AEVRSRNEAIRLKKKMEgdlNEIEIQLSHANRQAAETLKHLRSVQgQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQ 1683
Cdd:pfam02463  769 LSLKEKELAEEREKTEK---LKVEEEKEEKLKAQEEELRALEEEL-KEEAELLEEEQLLIEQEEKIKEEELEELALELKE 844
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1684 AEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDarnaEEKAKKAITDA 1763
Cdd:pfam02463  845 EQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKL----NLLEEKENEIE 920
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1764 AMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRK 1843
Cdd:pfam02463  921 ERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERL 1000
                          890       900
                   ....*....|....*....|.
gi 2462555497 1844 YERRVKELTYQSEEDRKNVLR 1864
Cdd:pfam02463 1001 EEEKKKLIRAIIEETCQRLKE 1021
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
842-1456 1.12e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 83.58  E-value: 1.12e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  842 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIK 921
Cdd:TIGR02169  379 EFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLE 458
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  922 EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREK---- 997
Cdd:TIGR02169  459 QLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGerya 538
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  998 KALQEAHQQALDDLQAEEDKVNS------------------LNKTKSKL---------------------EQQ------- 1031
Cdd:TIGR02169  539 TAIEVAAGNRLNNVVVEDDAVAKeaiellkrrkagratflpLNKMRDERrdlsilsedgvigfavdlvefDPKyepafky 618
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1032 -------VEDLESSLEQEKKLR-VDLE---------------------RNKRKLEGDLKLAQESILDLENDKQQLDERLK 1082
Cdd:TIGR02169  619 vfgdtlvVEDIEAARRLMGKYRmVTLEgelfeksgamtggsraprggiLFSRSEPAELQRLRERLEGLKRELSSLQSELR 698
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1083 KKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYareleelserleeaggvtstqi 1162
Cdd:TIGR02169  699 RIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENV---------------------- 756
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1163 elnkkrEAEFLKLRRDLEEATLQHEAMVATLRKKHADsvaELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKS 1242
Cdd:TIGR02169  757 ------KSELKELEARIEELEEDLHKLEEALNDLEAR---LSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLE 827
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1243 KANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKsrlqteaGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE 1322
Cdd:TIGR02169  828 KEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKK-------EELEEELEELEAALRDLESRLGDLKKERDELEAQLRE 900
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1323 ENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQwrTKYETDAIQRTEELEEAKKKLAQRLQDSE 1402
Cdd:TIGR02169  901 LERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEE--ELSLEDVQAELQRVEEEIRALEPVNMLAI 978
                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462555497 1403 EQVEAVNAKCASLEKTKQRLQGEVEDL-----MVDVERANSLAAALDKKQRNFDKVLAE 1456
Cdd:TIGR02169  979 QEYEEVLKRLDELKEKRAKLEEERKAIlerieEYEKKKREVFMEAFEAINENFNEIFAE 1037
PTZ00121 PTZ00121
MAEBL; Provisional
1078-1839 1.16e-15

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 83.65  E-value: 1.16e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1078 DERLK--KKDFEYCQLQSKVEDEQTLglQFQKKIKELQARIEELEEEIEAERATRAKTEK-QRSDYARELEELSERLEEA 1154
Cdd:PTZ00121  1069 DEGLKpsYKDFDFDAKEDNRADEATE--EAFGKAEEAKKTETGKAEEARKAEEAKKKAEDaRKAEEARKAEDARKAEEAR 1146
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1155 GGVTSTQIELNKK-REAEFLKLRRDLEEATLQHEAMVAT-LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEfKLEIDDL 1232
Cdd:PTZ00121  1147 KAEDAKRVEIARKaEDARKAEEARKAEDAKKAEAARKAEeVRKAEELRKAEDARKAEAARKAEEERKAEEAR-KAEDAKK 1225
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1233 SSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQrsLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQ 1312
Cdd:PTZ00121  1226 AEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEAR--MAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKK 1303
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1313 TEELKRQLEEENKAKNALAHAlQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEE---LEE 1389
Cdd:PTZ00121  1304 ADEAKKKAEEAKKADEAKKKA-EEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAkkkADA 1382
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1390 AKKKLAQRLQDSEEQVEAVNAKCASLE-KTKQRLQGEVEDLMVDVERANSLAAAldKKQRNFDKVLAEWKTKCEESQAEL 1468
Cdd:PTZ00121  1383 AKKKAEEKKKADEAKKKAEEDKKKADElKKAAAAKKKADEAKKKAEEKKKADEA--KKKAEEAKKADEAKKKAEEAKKAE 1460
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1469 EASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEiADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEA 1548
Cdd:PTZ00121  1461 EAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADE-AKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEA 1539
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1549 EAALEHEEAKILRIQLELTqvKSEIDRKIAEKDEEiEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDlneiEI 1628
Cdd:PTZ00121  1540 KKAEEKKKADELKKAEELK--KAEEKKKAEEAKKA-EEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAE----EA 1612
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1629 QLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERA----RKLAE 1704
Cdd:PTZ00121  1613 KKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAeedeKKAAE 1692
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1705 QELLDSNErvqllhtqntslihtKKKLEtdlmQLQSEVEDASRDArnaeEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1784
Cdd:PTZ00121  1693 ALKKEAEE---------------AKKAE----ELKKKEAEEKKKA----EELKKAEEENKIKAEEAKKEAEEDKKKAEEA 1749
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462555497 1785 KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVK 1839
Cdd:PTZ00121  1750 KKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIF 1804
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
836-1330 2.89e-15

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 81.61  E-value: 2.89e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  836 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQ 915
Cdd:TIGR04523  119 KNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLK 198
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  916 LEAKIKEVTERAEDEEEINAELT---AKKRKLEDECSELKKDIDDLELTLAKVE---------------------KEKHA 971
Cdd:TIGR04523  199 LELLLSNLKKKIQKNKSLESQISelkKQNNQLKDNIEKKQQEINEKTTEISNTQtqlnqlkdeqnkikkqlsekqKELEQ 278
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  972 TENKVKNLTEELSGLDETIAKLTREKKalQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLER 1051
Cdd:TIGR04523  279 NNKKIKELEKQLNQLKSEISDLNNQKE--QDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSES 356
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1052 NKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRA 1131
Cdd:TIGR04523  357 ENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETII 436
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1132 KTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQ---HEAMVATLRKKHADS---VAELG 1205
Cdd:TIGR04523  437 KNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKElksKEKELKKLNEEKKELeekVKDLT 516
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1206 EQIDNLQRVKQKLEKEKSEFKLEIDDLSS--SMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT 1283
Cdd:TIGR04523  517 KKISSLKEKIEKLESEKKEKESKISDLEDelNKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEK 596
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 2462555497 1284 EAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNAL 1330
Cdd:TIGR04523  597 EKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKL 643
PTZ00121 PTZ00121
MAEBL; Provisional
845-1596 3.80e-15

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 82.11  E-value: 3.80e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQlEAKIKEVT 924
Cdd:PTZ00121  1091 EATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAE-DARKAEEA 1169
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  925 ERAEDEEEINAeltAKKRKLEDECSELKKDIDDLELTLA-KVEKEKHATENKV---KNLTEELSGLDETIAKLTREKKAL 1000
Cdd:PTZ00121  1170 RKAEDAKKAEA---ARKAEEVRKAEELRKAEDARKAEAArKAEEERKAEEARKaedAKKAEAVKKAEEAKKDAEEAKKAE 1246
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1001 QEAHQQALDDLQAEEDKVNSLNKTKSKLEQ--QVEDLESSLEQEKKLRVDLERNKRKLEgDLKLAQESILDLENDKQQLD 1078
Cdd:PTZ00121  1247 EERNNEEIRKFEEARMAHFARRQAAIKAEEarKADELKKAEEKKKADEAKKAEEKKKAD-EAKKKAEEAKKADEAKKKAE 1325
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1079 ERLKKKDfeycQLQSKVEdEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAggvt 1158
Cdd:PTZ00121  1326 EAKKKAD----AAKKKAE-EAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEA---- 1396
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1159 STQIELNKKREAEflkLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMES 1238
Cdd:PTZ00121  1397 KKKAEEDKKKADE---LKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKAD 1473
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1239 VSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSElttQKSRLQTEAGELSRQLEEkesiVSQLSRSKQAFTQQTEELKR 1318
Cdd:PTZ00121  1474 EAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEA---KKKADEAKKAEEAKKADE----AKKAEEAKKADEAKKAEEKK 1546
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1319 QLEEENKAKNaLAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEvaQWRTKYETDAIQRTEEL---EEAKKKLA 1395
Cdd:PTZ00121  1547 KADELKKAEE-LKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIE--EVMKLYEEEKKMKAEEAkkaEEAKIKAE 1623
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1396 QRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEdlmvdvERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKES 1475
Cdd:PTZ00121  1624 ELKKAEEEKKKVEQLKKKEAEEKKKAEELKKA------EEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKE 1697
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1476 RSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSrkqiELEKADIQLALEEAEAALEHE 1555
Cdd:PTZ00121  1698 AEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKD----EEEKKKIAHLKKEEEKKAEEI 1773
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|.
gi 2462555497 1556 EAKILRIQLEltQVKSEIDRKIAEKDEEIEQLKRNYQRTVE 1596
Cdd:PTZ00121  1774 RKEKEAVIEE--ELDEEDEKRRMEVDKKIKDIFDNFANIIE 1812
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1287-1804 8.83e-15

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 80.47  E-value: 8.83e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1287 ELSRQLEEKES--IVSQLSRSKQAFTQQTEELKRQLEEENKAKnalahalqSSRHDCDLLREQYEEEQEGKAELQRALSK 1364
Cdd:PRK02224   191 QLKAQIEEKEEkdLHERLNGLESELAELDEEIERYEEQREQAR--------ETRDEADEVLEEHEERREELETLEAEIED 262
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1365 ANSEVAQWRTKYET------DAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANS 1438
Cdd:PRK02224   263 LRETIAETEREREElaeevrDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQAHNE 342
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1439 LAAALDKKQRNFDKVLAEWKTKCEESQAELEAS---LKESRS----LSTELFKLKNAYEEALDQLETVKRENKNLEQEIA 1511
Cdd:PRK02224   343 EAESLREDADDLEERAEELREEAAELESELEEAreaVEDRREeieeLEEEIEELRERFGDAPVDLGNAEDFLEELREERD 422
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1512 DLTEQIAENGKTIHELEKSRKQIE--------------LEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDR-- 1575
Cdd:PRK02224   423 ELREREAELEATLRTARERVEEAEalleagkcpecgqpVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEERLERae 502
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1576 KIAEKDEEIEQLKRNYQRTVETMQSAlDAEVRSRNEAIRLKKKMEGDLN-EIEIQLSHANRQAAETLKHLRSVqGQLKDT 1654
Cdd:PRK02224   503 DLVEAEDRIERLEERREDLEELIAER-RETIEEKRERAEELRERAAELEaEAEEKREAAAEAEEEAEEAREEV-AELNSK 580
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1655 QLHLDDALRGQEDLKEQLAIVERranlLQAEVEELRATLEQ-----TERARKLAEQelldsNERVQllhtqntslihtkk 1729
Cdd:PRK02224   581 LAELKERIESLERIRTLLAAIAD----AEDEIERLREKREAlaelnDERRERLAEK-----RERKR-------------- 637
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1730 kletdlmQLQSEVEDAS-RDARNAEEKAKKAITDAAMMAEELKKEQDT--------SAHLERMK------KNLEQTVKDL 1794
Cdd:PRK02224   638 -------ELEAEFDEARiEEAREDKERAEEYLEQVEEKLDELREERDDlqaeigavENELEELEelrerrEALENRVEAL 710
                          570
                   ....*....|
gi 2462555497 1795 QHRLDEAEQL 1804
Cdd:PRK02224   711 EALYDEAEEL 720
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
844-1599 1.12e-14

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 80.40  E-value: 1.12e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  844 AETEKEMATMKEefqktkdELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEV 923
Cdd:pfam02463  275 KEEEKEKKLQEE-------ELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKEL 347
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  924 TERAEDEEEINAELTAKKRKLEdecsELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEA 1003
Cdd:pfam02463  348 EIKREAEEEEEEELEKLQEKLE----QLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKE 423
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1004 HQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKK 1083
Cdd:pfam02463  424 EKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKES 503
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1084 KDFEYCQ--LQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQ 1161
Cdd:pfam02463  504 KARSGLKvlLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLL 583
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1162 IELNKKREAEFLKLRRDLE--EATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESV 1239
Cdd:pfam02463  584 IPKLKLPLKSIAVLEIDPIlnLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSE 663
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1240 SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKEsiVSQLSRSKQAFTQQTEELKRQ 1319
Cdd:pfam02463  664 VKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAE--ELLADRVQEAQDKINEELKLL 741
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1320 LEEENKAKNALAHALQSSRHDCDLLREqyEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1399
Cdd:pfam02463  742 KQKIDEEEEEEEKSRLKKEEKEEEKSE--LSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEE 819
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1400 DSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERAN----SLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKES 1475
Cdd:pfam02463  820 EQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELErleeEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEK 899
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1476 RSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHE 1555
Cdd:pfam02463  900 KELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMA 979
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*
gi 2462555497 1556 EAKILRIQLELTQVKSEIDRKIAEKDEEI-EQLKRNYQRTVETMQ 1599
Cdd:pfam02463  980 IEEFEEKEERYNKDELEKERLEEEKKKLIrAIIEETCQRLKEFLE 1024
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1227-1886 1.45e-14

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 79.72  E-value: 1.45e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1227 LEIDDLSSSMESVSKSKANLEKICRTLEDQLSeargKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSK 1306
Cdd:PRK03918   155 LGLDDYENAYKNLGEVIKEIKRRIERLEKFIK----RTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEV 230
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1307 Q---AFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQ--RALSKANSEVAQWRTKYEtdai 1381
Cdd:PRK03918   231 KeleELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKelKEKAEEYIKLSEFYEEYL---- 306
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1382 QRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVdveranslaaaLDKKQRNFDKVLAEwktkc 1461
Cdd:PRK03918   307 DELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEE-----------LEERHELYEEAKAK----- 370
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1462 eesQAELEASLKESRSLSTElfKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADI 1541
Cdd:PRK03918   371 ---KEELERLKKRLTGLTPE--KLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGREL 445
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1542 QLALEeaeaaleheeakiLRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRtvetmqsaLDAEVRSRNEAIRLKKKMEg 1621
Cdd:PRK03918   446 TEEHR-------------KELLEEYTAELKRIEKELKEIEEKERKLRKELRE--------LEKVLKKESELIKLKELAE- 503
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1622 DLNEIEIQLSHAN----RQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANllqaEVEELRATLEQte 1697
Cdd:PRK03918   504 QLKELEEKLKKYNleelEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLD----ELEEELAELLK-- 577
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1698 RARKLAEQELLDSNERVQLLHTQNTSLIhtkkkletdlmqlqsEVEDASRDARNAEEKAKKAITDAAMMAEELkkeQDTS 1777
Cdd:PRK03918   578 ELEELGFESVEELEERLKELEPFYNEYL---------------ELKDAEKELEREEKELKKLEEELDKAFEEL---AETE 639
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1778 AHLERMKKNLEQtvkdLQHRLDEAEQlalKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTyQSEE 1857
Cdd:PRK03918   640 KRLEELRKELEE----LEKKYSEEEY---EELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEERE-KAKK 711
                          650       660
                   ....*....|....*....|....*....
gi 2462555497 1858 DRKNVLRLQDLVDKLQVKVKSYKRQAEEA 1886
Cdd:PRK03918   712 ELEKLEKALERVEELREKVKKYKALLKER 740
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
1196-1920 6.40e-14

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 77.57  E-value: 6.40e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1196 KHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGK--------NEEI 1267
Cdd:pfam12128  238 KIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKRDElngelsaaDAAV 317
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1268 QRSLSELTT--------QKSRLQTEAGELSR------QLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHa 1333
Cdd:pfam12128  318 AKDRSELEAledqhgafLDADIETAAADQEQlpswqsELENLEERLKALTGKHQDVTAKYNRRRSKIKEQNNRDIAGIK- 396
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1334 lqssrhdcDLLREQYEEEQEGKAELQRALSKANSEvaqWRTKYEtdaiQRTEELEEAKKKLAQRLQDSEEQVEAVNAKca 1413
Cdd:pfam12128  397 --------DKLAKIREARDRQLAVAEDDLQALESE---LREQLE----AGKLEFNEEEYRLKSRLGELKLRLNQATAT-- 459
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1414 slektkqrlqgevEDLMVDveranslaaaldkkQRNFDkvlaewkTKCEESQAELEASLKESRSLSTELFKLKNAYEEAL 1493
Cdd:pfam12128  460 -------------PELLLQ--------------LENFD-------ERIERAREEQEAANAEVERLQSELRQARKRRDQAS 505
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1494 DQLETVKRENKNLEQEIADLTEQ-IAENGKTIHELeksRKQIELEKADIQLAleeaeaaleheeakILRIQLELTQVKSE 1572
Cdd:pfam12128  506 EALRQASRRLEERQSALDELELQlFPQAGTLLHFL---RKEAPDWEQSIGKV--------------ISPELLHRTDLDPE 568
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1573 IDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIrlkkkmegdlnEIEIQLSHANRQAAEtlKHLRSVQGQLK 1652
Cdd:pfam12128  569 VWDGSVGGELNLYGVKLDLKRIDVPEWAASEEELRERLDKA-----------EEALQSAREKQAAAE--EQLVQANGELE 635
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1653 DTQLHLDDALRGQEDLKEQLaivERRANLLQAEVeelRATLEQTERARKLAEQELLD-SNERVQLLHTQNTSLIHTKKKL 1731
Cdd:pfam12128  636 KASREETFARTALKNARLDL---RRLFDEKQSEK---DKKNKALAERKDSANERLNSlEAQLKQLDKKHQAWLEEQKEQK 709
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1732 ETDLMQLQS---EVEDASRD-------ARNAEEKAKKAITDA--AMMAEELKK---EQDTSAHLERMKKNLEQTVKDLQH 1796
Cdd:pfam12128  710 REARTEKQAywqVVEGALDAqlallkaAIAARRSGAKAELKAleTWYKRDLASlgvDPDVIAKLKREIRTLERKIERIAV 789
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1797 RLDEA--------EQLALKGGKKQIQKLETRiRELEfELEGEQKKNTESVKglrkyeRRVKELTYQSEEDRKNVLRLQDL 1868
Cdd:pfam12128  790 RRQEVlryfdwyqETWLQRRPRLATQLSNIE-RAIS-ELQQQLARLIADTK------LRRAKLEMERKASEKQQVRLSEN 861
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462555497 1869 VDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQheLEEAEERADIAESQVNK 1920
Cdd:pfam12128  862 LRGLRCEMSKLATLKEDANSEQAQGSIGERLAQ--LEDLKLKRDYLSESVKK 911
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
916-1445 7.89e-14

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 77.39  E-value: 7.89e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  916 LEAKIKEVTERAE--DEEEINAELT--------AKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSG 985
Cdd:PRK02224   211 LESELAELDEEIEryEEQREQARETrdeadevlEEHEERREELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEE 290
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  986 LDETIAKLtREKKALQEAHQQALDDLQAEedkvnslnktkskLEQQVEDLESSLEQEkklRVDLERNKRKLEGdlklAQE 1065
Cdd:PRK02224   291 LEEERDDL-LAEAGLDDADAEAVEARREE-------------LEDRDEELRDRLEEC---RVAAQAHNEEAES----LRE 349
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1066 SILDLEndkqqldERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELE 1145
Cdd:PRK02224   350 DADDLE-------ERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERD 422
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1146 ELSERLeeaggvtstqielnKKREAEFLKLRRDLEEA-TLQHEAMVATLRKK-----HADSVAELGEQIDNLQRVKQKLE 1219
Cdd:PRK02224   423 ELRERE--------------AELEATLRTARERVEEAeALLEAGKCPECGQPvegspHVETIEEDRERVEELEAELEDLE 488
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1220 KEKSEFKLEIDDLSSSMESVSKSKANLEKIcRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIV 1299
Cdd:PRK02224   489 EEVEEVEERLERAEDLVEAEDRIERLEERR-EDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEA 567
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1300 SQLSRSKQAFTQQTEELKRQLEEENKAKNALAhALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD 1379
Cdd:PRK02224   568 EEAREEVAELNSKLAELKERIESLERIRTLLA-AIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFDEA 646
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462555497 1380 AIqrtEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK 1445
Cdd:PRK02224   647 RI---EEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELEELRERREALENRVEA 709
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
973-1627 1.12e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 76.64  E-value: 1.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  973 ENKVKNLTE---ELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRV-- 1047
Cdd:PRK03918   161 ENAYKNLGEvikEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEei 240
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1048 -DLERNKRKLEGDLKlaqesilDLENDKQQLDERLKKKDFEYCQLQSKVEDeqtlglqfQKKIKELQARIEELEEEIEAE 1126
Cdd:PRK03918   241 eELEKELESLEGSKR-------KLEEKIRELEERIEELKKEIEELEEKVKE--------LKELKEKAEEYIKLSEFYEEY 305
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1127 RATRAKTEKQRSDYARELEELSErleeaggvtstQIELNKKREAEFLKLRRDLEEatlqheamvatLRKKhadsVAELGE 1206
Cdd:PRK03918   306 LDELREIEKRLSRLEEEINGIEE-----------RIKELEEKEERLEELKKKLKE-----------LEKR----LEELEE 359
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1207 QIDNLQRVKQKLEkEKSEFKLEIDDLsssmesvskskaNLEKICRTLEdqlsEARGKNEEIQRSLSELTTQKSRLQTEAG 1286
Cdd:PRK03918   360 RHELYEEAKAKKE-ELERLKKRLTGL------------TPEKLEKELE----ELEKAKEEIEEEISKITARIGELKKEIK 422
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1287 ELSRQLEEKESIVSQLSRSKQAFtqqTEELKRQLEEENKAKnalahaLQSSRHDCDLLREQYEEEQEGKAELQRALSKaN 1366
Cdd:PRK03918   423 ELKKAIEELKKAKGKCPVCGREL---TEEHRKELLEEYTAE------LKRIEKELKEIEEKERKLRKELRELEKVLKK-E 492
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1367 SEVAQWRTKYetdaiqrtEELEEAKKKLaqrlqdSEEQVEAVNAKCASLEKTKQR---LQGEVEDLMVDVERANSL---A 1440
Cdd:PRK03918   493 SELIKLKELA--------EQLKELEEKL------KKYNLEELEKKAEEYEKLKEKlikLKGEIKSLKKELEKLEELkkkL 558
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1441 AALDKKQRNFDKVLAEWKTKCEE----SQAELEASLKESRSLSTELFKLKNAYEEaldqLETVKRENKNLEQEIADLTEQ 1516
Cdd:PRK03918   559 AELEKKLDELEEELAELLKELEElgfeSVEELEERLKELEPFYNEYLELKDAEKE----LEREEKELKKLEEELDKAFEE 634
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1517 IAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLE-LTQVKSEIDRKIAEKDEEIEQLKRnYQRTV 1595
Cdd:PRK03918   635 LAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEeLEKRREEIKKTLEKLKEELEEREK-AKKEL 713
                          650       660       670
                   ....*....|....*....|....*....|...
gi 2462555497 1596 ETMQSALDAEVRSRNEAIRLKKKM-EGDLNEIE 1627
Cdd:PRK03918   714 EKLEKALERVEELREKVKKYKALLkERALSKVG 746
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
897-1483 1.25e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 76.64  E-value: 1.25e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  897 ENLLDAEERCDQLIKAKFQ-LEAKIKEVTERAEDEEEINAELtAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 975
Cdd:PRK03918   182 EKFIKRTENIEELIKEKEKeLEEVLREINEISSELPELREEL-EKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEK 260
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  976 VKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEE------DKVNSLNKTKSKLEQQV----------EDLESSL 1039
Cdd:PRK03918   261 IRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEfyeeylDELREIEKRLSRLEEEIngieerikelEEKEERL 340
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1040 EQEKKLRVDLERNKRKLEGDLKLAQEsILDLENDKQQLDERLKKKDFEycQLQSKVEDEQTLGLQFQKKIKELQARIEEL 1119
Cdd:PRK03918   341 EELKKKLKELEKRLEELEERHELYEE-AKAKKEELERLKKRLTGLTPE--KLEKELEELEKAKEEIEEEISKITARIGEL 417
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1120 EEEIEAERATRAKTEKQRSDYARELEELSERLEEaggvtstqiELNKKREAEFLKLRRDLEEATLQHEAMVATLRK---- 1195
Cdd:PRK03918   418 KKEIKELKKAIEELKKAKGKCPVCGRELTEEHRK---------ELLEEYTAELKRIEKELKEIEEKERKLRKELRElekv 488
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1196 -KHADSVAELGEQIDNLQRVKQKLEKEKSEfKLEIDDLSSSMESVSKSKanLEKICRTLEDQLSEArgknEEIQRSLSEL 1274
Cdd:PRK03918   489 lKKESELIKLKELAEQLKELEEKLKKYNLE-ELEKKAEEYEKLKEKLIK--LKGEIKSLKKELEKL----EELKKKLAEL 561
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1275 TTQKSRLQTEAGELSRQLEEKEsivsqlSRSKQAFTQQTEELKRQLEEENKAKNAlAHALQSSRHDCDLLREQYEEEQEG 1354
Cdd:PRK03918   562 EKKLDELEEELAELLKELEELG------FESVEELEERLKELEPFYNEYLELKDA-EKELEREEKELKKLEEELDKAFEE 634
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1355 KAELQRALSKANSEVAQWRTKYETDaiqRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVE 1434
Cdd:PRK03918   635 LAETEKRLEELRKELEELEKKYSEE---EYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKK 711
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*....
gi 2462555497 1435 RANSLAAALDKKQRNFDKVlAEWKTKCEesqaelEASLKESRSLSTELF 1483
Cdd:PRK03918   712 ELEKLEKALERVEELREKV-KKYKALLK------ERALSKVGEIASEIF 753
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
867-1606 1.28e-13

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 76.55  E-value: 1.28e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  867 SEAKRKELEEKLVTLvqekndLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLED 946
Cdd:TIGR00618  121 LAAKKSETEEVIHDL------LKLDYKTFTRVVLLPQGEFAQFLKAKSKEKKELLMNLFPLDQYTQLALMEFAKKKSLHG 194
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  947 ECSELKKDIDDLELTLAKVEKEKHAT----ENKVKNLTEELSGLDETIAKLTREKKALQEAH--QQALDDLQAEEDKVNS 1020
Cdd:TIGR00618  195 KAELLTLRSQLLTLCTPCMPDTYHERkqvlEKELKHLREALQQTQQSHAYLTQKREAQEEQLkkQQLLKQLRARIEELRA 274
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1021 ----LNKTKSKLEQQVEDLESSLEQEKKLRVDLER---NKRKLEGDLKLAQESILDLENDKQQLD----ERLKKKDFEYC 1089
Cdd:TIGR00618  275 qeavLEETQERINRARKAAPLAAHIKAVTQIEQQAqriHTELQSKMRSRAKLLMKRAAHVKQQSSieeqRRLLQTLHSQE 354
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1090 QLQSKVEDEQTLGL-QFQKKIKELQ---ARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAG--GVTSTQIE 1163
Cdd:TIGR00618  355 IHIRDAHEVATSIReISCQQHTLTQhihTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGqlAHAKKQQE 434
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1164 LNKKREAeflklrrdLEEATLQHEAMVATLRKKHADSVAE-LGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKS 1242
Cdd:TIGR00618  435 LQQRYAE--------LCAAAITCTAQCEKLEKIHLQESAQsLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPL 506
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1243 KA-------------NLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQA- 1308
Cdd:TIGR00618  507 CGscihpnparqdidNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDi 586
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1309 --FTQQTEELKRQLEEENKAKNALAhalqssrhdcDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEE 1386
Cdd:TIGR00618  587 pnLQNITVRLQDLTEKLSEAEDMLA----------CEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLTLT 656
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1387 LEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLmvdvERANSLAAALDKKQRNFDKVLAEWKTKCEESQA 1466
Cdd:TIGR00618  657 QERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEML----AQCQTLLRELETHIEEYDREFNEIENASSSLGS 732
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1467 ELEA-------SLKESRSLS-TELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEK 1538
Cdd:TIGR00618  733 DLAAredalnqSLKELMHQArTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEI 812
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462555497 1539 ADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEV 1606
Cdd:TIGR00618  813 PSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDKLNG 880
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
850-1706 1.54e-13

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 76.55  E-value: 1.54e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  850 MATMKEEFQKTKDELA---KSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD-AEERCDQLIKAKFQLEAKIKEVTE 925
Cdd:pfam02463  147 IAMMKPERRLEIEEEAagsRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKlKEQAKKALEYYQLKEKLELEEEYL 226
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  926 RAEDEEEINAE----LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQ 1001
Cdd:pfam02463  227 LYLDYLKLNEEridlLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLE 306
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1002 EAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSL-------EQEKKLRVDLERNKRKLEgdlkLAQESILDLENDK 1074
Cdd:pfam02463  307 RRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELkeleikrEAEEEEEEELEKLQEKLE----QLEEELLAKKKLE 382
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEA 1154
Cdd:pfam02463  383 SERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLK 462
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1155 GGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSS 1234
Cdd:pfam02463  463 DELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYK 542
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1235 SMESVSKSKANLEKICRTLEDQLSEARGKneeiqRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTE 1314
Cdd:pfam02463  543 VAISTAVIVEVSATADEVEERQKLVRALT-----ELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADE 617
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1315 ELKRQLEEENKAKnalaHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTK-YETDAIQRTEELEEAKKK 1393
Cdd:pfam02463  618 DDKRAKVVEGILK----DTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKElLEIQELQEKAESELAKEE 693
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1394 LAQRLQDSEEQVEAVnakcASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLK 1473
Cdd:pfam02463  694 ILRRQLEIKKKEQRE----KEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSEL 769
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1474 ESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALE 1553
Cdd:pfam02463  770 SLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLE 849
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1554 HEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHA 1633
Cdd:pfam02463  850 KLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEI 929
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462555497 1634 NRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQE 1706
Cdd:pfam02463  930 LLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEE 1002
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
866-1579 3.54e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 75.06  E-value: 3.54e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  866 KSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLE 945
Cdd:TIGR04523   30 KQDTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKIN 109
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  946 DEC-------SELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKV 1018
Cdd:TIGR04523  110 SEIkndkeqkNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNI 189
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1019 NSLNKTKSKLEQQVEDLESSLEQEKKLRVDLErnkrKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDE 1098
Cdd:TIGR04523  190 DKIKNKLLKLELLLSNLKKKIQKNKSLESQIS----ELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKI 265
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1099 QTlglQFQKKIKELQARIEELEEEIEAERATRAKTEkqrsdyareleelserleeaggvtstqiELNKKREAEFLKlrrd 1178
Cdd:TIGR04523  266 KK---QLSEKQKELEQNNKKIKELEKQLNQLKSEIS----------------------------DLNNQKEQDWNK---- 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1179 leeatlqheamvatlrkkhadsvaELGEQIDNLQRVKQKLEKEKSEFKLEIDDLsssmesvskskanlekicrtledqls 1258
Cdd:TIGR04523  311 ------------------------ELKSELKNQEKKLEEIQNQISQNNKIISQL-------------------------- 340
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1259 eargkNEEIqrslSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAF-------TQQTEELKRQLEEENKAKNALA 1331
Cdd:TIGR04523  341 -----NEQI----SQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYkqeiknlESQINDLESKIQNQEKLNQQKD 411
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1332 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYE------TDAIQRTEELEEAKKKLAQRLQDSEEQV 1405
Cdd:TIGR04523  412 EQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKnldntrESLETQLKVLSRSINKIKQNLEQKQKEL 491
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1406 EAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASL--KESRSLSTELF 1483
Cdd:TIGR04523  492 KSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENleKEIDEKNKEIE 571
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1484 KLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ 1563
Cdd:TIGR04523  572 ELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIK 651
                          730
                   ....*....|....*....
gi 2462555497 1564 LELTQVK---SEIDRKIAE 1579
Cdd:TIGR04523  652 ETIKEIRnkwPEIIKKIKE 670
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1199-1872 1.06e-12

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 73.80  E-value: 1.06e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1199 DSVAELGEQIDNLQRVKQKLEKEKSEFKL--EIDDLSSSMESVSKSKANLEKICRTLEDQlsEARGKNEEIQRSLSELTT 1276
Cdd:COG4913    225 EAADALVEHFDDLERAHEALEDAREQIELlePIRELAERYAAARERLAELEYLRAALRLW--FAQRRLELLEAELEELRA 302
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1277 QKSRLQTEAGELSRQLEEKESIVSQLSRSKQAF-TQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1355
Cdd:COG4913    303 ELARLEAELERLEARLDALREELDELEAQIRGNgGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEF 382
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1356 AELQRALSKANSEVAQWRTKYE---TDAIQRTEELEEAKKKLAQRLQD--------SEEQVEAVNAKCASLEKTKQRL-- 1422
Cdd:COG4913    383 AALRAEAAALLEALEEELEALEealAEAEAALRDLRRELRELEAEIASlerrksniPARLLALRDALAEALGLDEAELpf 462
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1423 --------------QGEVE--------DLMVDVERANSLAAALDK---KQR-NFDKVlaewktkcEESQAELEASLKESR 1476
Cdd:COG4913    463 vgelievrpeeerwRGAIErvlggfalTLLVPPEHYAAALRWVNRlhlRGRlVYERV--------RTGLPDPERPRLDPD 534
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1477 SLSTELFKLKNAYEEALDQL----------ETVkrenKNLEQEIADLTE--QIAENGkTIHELEK-------------SR 1531
Cdd:COG4913    535 SLAGKLDFKPHPFRAWLEAElgrrfdyvcvDSP----EELRRHPRAITRagQVKGNG-TRHEKDDrrrirsryvlgfdNR 609
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1532 KQIELEKADIQlaleeaeaaleheeakilRIQLELTQVKSEIdRKIAEKDEEIEQLKRNYQRTVETMQSALD-----AEV 1606
Cdd:COG4913    610 AKLAALEAELA------------------ELEEELAEAEERL-EALEAELDALQERREALQRLAEYSWDEIDvasaeREI 670
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1607 RSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANL-LQAE 1685
Cdd:COG4913    671 AELEAELERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLeLRAL 750
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1686 VEELRATLEQTERARKLAEQelldsnervqlLHTQNTSLIHTKKKLETDLMQLQSE--------VEDASRDARNAEEKAK 1757
Cdd:COG4913    751 LEERFAAALGDAVERELREN-----------LEERIDALRARLNRAEEELERAMRAfnrewpaeTADLDADLESLPEYLA 819
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1758 kaitdaamMAEELkKEQDTSAHLERMKKNLEQT----VKDLQHRLDEAEQLAlkggKKQIQKLETRIRELEF------EL 1827
Cdd:COG4913    820 --------LLDRL-EEDGLPEYEERFKELLNENsiefVADLLSKLRRAIREI----KERIDPLNDSLKRIPFgpgrylRL 886
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1828 EGEQKKNTEsvkgLRKYERRVKELT-----YQSEEDRKNVLRLQDLVDKL 1872
Cdd:COG4913    887 EARPRPDPE----VREFRQELRAVTsgaslFDEELSEARFAALKRLIERL 932
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1382-1923 1.16e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 73.56  E-value: 1.16e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1382 QRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKqrlqGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKC 1461
Cdd:PRK03918   200 KELEEVLREINEISSELPELREELEKLEKEVKELEELK----EEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEI 275
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1462 EESQaELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAE---NGKTIHELEKSRKQIELEK 1538
Cdd:PRK03918   276 EELE-EKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKEleeKEERLEELKKKLKELEKRL 354
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1539 ADIQLALEEAEaaleheeaKILRIQLELTQVKSEIdrkiaeKDEEIEQLKRNYQrtvetmqsaldaevrsrnEAIRLKKK 1618
Cdd:PRK03918   355 EELEERHELYE--------EAKAKKEELERLKKRL------TGLTPEKLEKELE------------------ELEKAKEE 402
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1619 MEGDLNEIEIQLSHANRQAAE---TLKHLRSVQGQLKDTQLHLDDALRGQ--EDLKEQLAIVERRANLLQAEVEELRATL 1693
Cdd:PRK03918   403 IEEEISKITARIGELKKEIKElkkAIEELKKAKGKCPVCGRELTEEHRKEllEEYTAELKRIEKELKEIEEKERKLRKEL 482
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1694 EQTERarklaeqeLLDSNERVQLLHTQNTSLIHTKKKLETDLMQlqsEVEDASRDARNAEEKAKKAITDAAMMAEELKKE 1773
Cdd:PRK03918   483 RELEK--------VLKKESELIKLKELAEQLKELEEKLKKYNLE---ELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKL 551
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1774 QDtsahLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEfELEGEQKKNTESVKGLRKYERRVKELTY 1853
Cdd:PRK03918   552 EE----LKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELE-PFYNEYLELKDAEKELEREEKELKKLEE 626
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462555497 1854 QSEEDRKNVLRLQDLVDKLQVKVKSYKRQ--AEEADEQANAHLTKFRK---AQHELEEAEERADIAESQVNKLRA 1923
Cdd:PRK03918   627 ELDKAFEELAETEKRLEELRKELEELEKKysEEEYEELREEYLELSRElagLRAELEELEKRREEIKKTLEKLKE 701
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
841-1386 1.89e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 72.79  E-value: 1.89e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  841 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKL--VTLVQEKNDLQLQVQAESENLLDAEERcdqLIKAKFQLEA 918
Cdd:PRK03918   245 KELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVkeLKELKEKAEEYIKLSEFYEEYLDELRE---IEKRLSRLEE 321
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  919 KIKEVTERAEDEEEINA---ELTAKKRKLEDECSELKKDIDDLELTLAKVEkekhatenKVKNLTEELSGLdeTIAKLTR 995
Cdd:PRK03918   322 EINGIEERIKELEEKEErleELKKKLKELEKRLEELEERHELYEEAKAKKE--------ELERLKKRLTGL--TPEKLEK 391
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  996 EKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKleGDLKLAQESILDLENDKQ 1075
Cdd:PRK03918   392 ELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRK--ELLEEYTAELKRIEKELK 469
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1076 QLDERLKKKDFEYCQLQSKVEDEQTLGLQFQ--KKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEE 1153
Cdd:PRK03918   470 EIEEKERKLRKELRELEKVLKKESELIKLKElaEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELE 549
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1154 aggvtstQIELNKKREAEFLKLRRDLEE--ATLQHEamvatLRKKHADSVAELGEQIDNLQRVKQK---LEKEKSEFKLE 1228
Cdd:PRK03918   550 -------KLEELKKKLAELEKKLDELEEelAELLKE-----LEELGFESVEELEERLKELEPFYNEyleLKDAEKELERE 617
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1229 IDDLSSSMESVSKSKANLEKIcrtlEDQLSEARGKNEEIQRSLSELTTQKSRLQTEagELSRQLEEKESIVSQLSRSKQA 1308
Cdd:PRK03918   618 EKELKKLEEELDKAFEELAET----EKRLEELRKELEELEKKYSEEEYEELREEYL--ELSRELAGLRAELEELEKRREE 691
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1309 FTQQTEELKRQLEEENKAKNALaHALQSSRHDCDLLREQY-----EEEQEGKAELQRALSKANSEVAQwrTKYETDAIQR 1383
Cdd:PRK03918   692 IKKTLEKLKEELEEREKAKKEL-EKLEKALERVEELREKVkkykaLLKERALSKVGEIASEIFEELTE--GKYSGVRVKA 768

                   ...
gi 2462555497 1384 TEE 1386
Cdd:PRK03918   769 EEN 771
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
845-1404 2.13e-12

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 72.84  E-value: 2.13e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  845 ETEKEMATMKEEFQKTKDELaksEAKRKELEEKLVTLVQEKNDLQLQVQAESE-NLLDAEERCDQLIKAKFQLEAKIKEV 923
Cdd:pfam15921  228 ELDTEISYLKGRIFPVEDQL---EALKSESQNKIELLLQQHQDRIEQLISEHEvEITGLTEKASSARSQANSIQSQLEII 304
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  924 TERAEDE---------------EEINAELTAKKRKLEDECSELKKD--IDDLELTLAKVEKEKHATENkvKNLTEELSGL 986
Cdd:pfam15921  305 QEQARNQnsmymrqlsdlestvSQLRSELREAKRMYEDKIEELEKQlvLANSELTEARTERDQFSQES--GNLDDQLQKL 382
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  987 DETIAKltREKKALQEAHQ-------------------QALDDLQAEEDKVNSLNKT-----KSKLEQQVEDLE---SSL 1039
Cdd:pfam15921  383 LADLHK--REKELSLEKEQnkrlwdrdtgnsitidhlrRELDDRNMEVQRLEALLKAmksecQGQMERQMAAIQgknESL 460
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1040 EQEKKLRVDLERNKRKLEG----------DLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEdeqtLGLQFQKKI 1109
Cdd:pfam15921  461 EKVSSLTAQLESTKEMLRKvveeltakkmTLESSERTVSDLTASLQEKERAIEATNAEITKLRSRVD----LKLQELQHL 536
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1110 K----ELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK-----KREAEFLKLRRDLE 1180
Cdd:pfam15921  537 KnegdHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKeindrRLELQEFKILKDKK 616
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1181 EATLQH-EAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKAN-------LEKICRT 1252
Cdd:pfam15921  617 DAKIRElEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNfrnkseeMETTTNK 696
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1253 LEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEK----ESIVSQLSRSKQAFTQQTEELKRQLEEENKAKN 1328
Cdd:pfam15921  697 LKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKrgqiDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQ 776
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462555497 1329 ALAHALQSSRH---DCDLLREQYEEEQEGKAELQRALSKANSEVAQWRtkyetDAIQRTEElEEAKKKLAQRLQDSEEQ 1404
Cdd:pfam15921  777 ELSTVATEKNKmagELEVLRSQERRLKEKVANMEVALDKASLQFAECQ-----DIIQRQEQ-ESVRLKLQHTLDVKELQ 849
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
847-1640 2.25e-12

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 72.77  E-value: 2.25e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEercdqLIKAKFQLEAKIKEVTER 926
Cdd:TIGR00606  311 QRTVREKERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARD-----SLIQSLATRLELDGFERG 385
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  927 AEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQ 1006
Cdd:TIGR00606  386 PFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQ 465
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1007 A---LDDLQAEEDKVNSLNKTKSKLEQQ--VEDLESSLEQEKKLRVDLERNKRKLEGDL------KLAQESILDLENDKQ 1075
Cdd:TIGR00606  466 LegsSDRILELDQELRKAERELSKAEKNslTETLKKEVKSLQNEKADLDRKLRKLDQEMeqlnhhTTTRTQMEMLTKDKM 545
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1076 QLDERLKKKDF----EYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERL 1151
Cdd:TIGR00606  546 DKDEQIRKIKSrhsdELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYE 625
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1152 EEAGGVTSTQIElnkkrEAEFLKLRRDLEEATLQhEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDD 1231
Cdd:TIGR00606  626 DKLFDVCGSQDE-----ESDLERLKEEIEKSSKQ-RAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISD 699
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1232 LSSSMESVSKSKANLEKICRTLEDQLSE----ARGKNEEIQRSLSELTTQKSRLQ---TEAGELSRQLEEKE----SIVS 1300
Cdd:TIGR00606  700 LQSKLRLAPDKLKSTESELKKKEKRRDEmlglAPGRQSIIDLKEKEIPELRNKLQkvnRDIQRLKNDIEEQEtllgTIMP 779
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1301 QLSRSKQAFTQQT--EELKRQLEEENKAKNALAHALQSSrhDCDLLREQYEEEQEGKAELQRALSKA---NSEVAQWRTK 1375
Cdd:TIGR00606  780 EEESAKVCLTDVTimERFQMELKDVERKIAQQAAKLQGS--DLDRTVQQVNQEKQEKQHELDTVVSKielNRKLIQDQQE 857
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1376 YETDAIQRTEELEEAKKKLAQRLQdseeQVEAVNAKCASLEKTKQRLQGEVEDLMvdvERANSLAAALDKKQRNFDKVLA 1455
Cdd:TIGR00606  858 QIQHLKSKTNELKSEKLQIGTNLQ----RRQQFEEQLVELSTEVQSLIREIKDAK---EQDSPLETFLEKDQQEKEELIS 930
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1456 EWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDqletvkRENKNLEQEIADLTEQIAENGKtihELEKSRKQIE 1535
Cdd:TIGR00606  931 SKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKD------DYLKQKETELNTVNAQLEECEK---HQEKINEDMR 1001
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1536 LEKADIQLALEEAEAALEHEEAKILRIQL-ELTQVKSEIDRKIAEkdEEIEQLKRNYQRtvetMQSALDAEVRSRNEAIR 1614
Cdd:TIGR00606 1002 LMRQDIDTQKIQERWLQDNLTLRKRENELkEVEEELKQHLKEMGQ--MQVLQMKQEHQK----LEENIDLIKRNHVLALG 1075
                          810       820
                   ....*....|....*....|....*.
gi 2462555497 1615 LKKKMEGDLNEIEIQLSHANRQAAET 1640
Cdd:TIGR00606 1076 RQKGYEKEIKHFKKELREPQFRDAEE 1101
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1415-1924 2.40e-12

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 72.46  E-value: 2.40e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1415 LEKTKQRLQGEVEDLMVDVERANSLAaalDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALD 1494
Cdd:pfam15921   76 IERVLEEYSHQVKDLQRRLNESNELH---EKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVH 152
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1495 QLETVKrenknleqeiaDLTEQIAENGKTihELEKSRKQIELEKADIQLALEEAEAALEHEEAKILR----IQLELTQVK 1570
Cdd:pfam15921  153 ELEAAK-----------CLKEDMLEDSNT--QIEQLRKMMLSHEGVLQEIRSILVDFEEASGKKIYEhdsmSTMHFRSLG 219
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1571 SEIDRKIAEKDEEIEQLKRNYqRTVETMQSALDAEVRSRNEAI--RLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQ 1648
Cdd:pfam15921  220 SAISKILRELDTEISYLKGRI-FPVEDQLEALKSESQNKIELLlqQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQ 298
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1649 GQLKDTQlhlddalrgqEDLKEQLAIVERRANLLQAEVEELRATLEQterARKLAEQELLDSNERVQLLHTQntslihtk 1728
Cdd:pfam15921  299 SQLEIIQ----------EQARNQNSMYMRQLSDLESTVSQLRSELRE---AKRMYEDKIEELEKQLVLANSE-------- 357
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1729 kkletdLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQlalkg 1808
Cdd:pfam15921  358 ------LTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNM----- 426
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1809 gkkQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKnvlRLQDLVDKLqvkvkSYKRQAEEADE 1888
Cdd:pfam15921  427 ---EVQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKE---MLRKVVEEL-----TAKKMTLESSE 495
                          490       500       510
                   ....*....|....*....|....*....|....*.
gi 2462555497 1889 QANAHLTKfrkaqhELEEAEERADIAESQVNKLRAK 1924
Cdd:pfam15921  496 RTVSDLTA------SLQEKERAIEATNAEITKLRSR 525
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
838-1429 3.85e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 71.63  E-value: 3.85e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  838 KPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLqlqvQAESENLLDAEERCDQLIKAKFQLE 917
Cdd:PRK03918   183 KFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKEL----EELKEEIEELEKELESLEGSKRKLE 258
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  918 AKIKEVTERAEdeeeinaELTAKKRKLEDECSELKKdiddleltLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREK 997
Cdd:PRK03918   259 EKIRELEERIE-------ELKKEIEELEEKVKELKE--------LKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEI 323
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  998 KALQEahqqALDDLQAEEDKVNSLNKTKSKLEQQVEDLESS---LEQEKKLRVDLERNKRKLEG-DLKLAQESILDLEND 1073
Cdd:PRK03918   324 NGIEE----RIKELEEKEERLEELKKKLKELEKRLEELEERhelYEEAKAKKEELERLKKRLTGlTPEKLEKELEELEKA 399
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1074 KQQLDERLKKKDFEYCQLQSKVEDEQTlGLQFQKKIK--------ELQARIEELEEEIEAERATRAKTEKQRSDYARELE 1145
Cdd:PRK03918   400 KEEIEEEISKITARIGELKKEIKELKK-AIEELKKAKgkcpvcgrELTEEHRKELLEEYTAELKRIEKELKEIEEKERKL 478
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1146 ELSErleeaggvtsTQIELNKKREAEFLKLR------RDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLE 1219
Cdd:PRK03918   479 RKEL----------RELEKVLKKESELIKLKelaeqlKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKEL 548
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1220 KEKSEFKLEIDDLSSSMESVSKSKANLEKICRTL----EDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEK 1295
Cdd:PRK03918   549 EKLEELKKKLAELEKKLDELEEELAELLKELEELgfesVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEEL 628
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1296 ESIVSQLSRSKQAFtqqtEELKRQLEEENKAKNalahalqssrhdcdllREQYEEEQEGKAELQRALSKANSEVaqwrtk 1375
Cdd:PRK03918   629 DKAFEELAETEKRL----EELRKELEELEKKYS----------------EEEYEELREEYLELSRELAGLRAEL------ 682
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462555497 1376 yetdaiqrtEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQgEVEDL 1429
Cdd:PRK03918   683 ---------EELEKRREEIKKTLEKLKEELEEREKAKKELEKLEKALE-RVEEL 726
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1571-1936 4.15e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 71.64  E-value: 4.15e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1571 SEIDRKIAEKDEEIEQLKRNYQR---TVETMQSALDAEVRSRNEAIR---LKKKME--------GDLNEIEIQLSHANRQ 1636
Cdd:TIGR02169  166 AEFDRKKEKALEELEEVEENIERldlIIDEKRQQLERLRREREKAERyqaLLKEKReyegyellKEKEALERQKEAIERQ 245
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1637 AAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQL-AIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQ 1715
Cdd:TIGR02169  246 LASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIkDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLA 325
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1716 LLHTQNTSLIHTKKKLETDLMQLQSEvedasRDARNAEEKAKKAITDAamMAEELKKEQDTSAHLERMKKNLEQTVKDLQ 1795
Cdd:TIGR02169  326 KLEAEIDKLLAEIEELEREIEEERKR-----RDKLTEEYAELKEELED--LRAELEEVDKEFAETRDELKDYREKLEKLK 398
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1796 HRLDEAeQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESvkglrkyERRVKELTYQSEEDRKNVLRLQDLVDKLQVK 1875
Cdd:TIGR02169  399 REINEL-KRELDRLQEELQRLSEELADLNAAIAGIEAKINEL-------EEEKEDKALEIKKQEWKLEQLAADLSKYEQE 470
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462555497 1876 VksYKRQAEEADEQanahlTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVH 1936
Cdd:TIGR02169  471 L--YDLKEEYDRVE-----KELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVH 524
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1413-1802 5.48e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 71.25  E-value: 5.48e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1413 ASLEKTKQRLQGEVEDLMVDVERANSLaaaLDKKQRNFDKvLAEWKTKCEESQAeLEASLKEsrslsTELFKLKNAYEEA 1492
Cdd:TIGR02169  166 AEFDRKKEKALEELEEVEENIERLDLI---IDEKRQQLER-LRREREKAERYQA-LLKEKRE-----YEGYELLKEKEAL 235
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1493 LDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADiqlaleeaeaaleHEEAKILRIQLELTQVKSE 1572
Cdd:TIGR02169  236 ERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKD-------------LGEEEQLRVKEKIGELEAE 302
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1573 I---DRKIAEKDEEIEQLKRNYQrtvetmqsaldaevrsrneairlkkKMEGDLNEIEIQLSHANRQAAETLKHLRSVQG 1649
Cdd:TIGR02169  303 IaslERSIAEKERELEDAEERLA-------------------------KLEAEIDKLLAEIEELEREIEEERKRRDKLTE 357
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1650 QLKDTQLHLddalrgqEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKK 1729
Cdd:TIGR02169  358 EYAELKEEL-------EDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIA 430
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462555497 1730 KLETDLMQLQSEVEDASRDARNAEEKAKKAitdAAMMAEELKKEQDTSAHLERMKKNLEQtvkdLQHRLDEAE 1802
Cdd:TIGR02169  431 GIEAKINELEEEKEDKALEIKKQEWKLEQL---AADLSKYEQELYDLKEEYDRVEKELSK----LQRELAEAE 496
Myosin_N pfam02736
Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the ...
33-77 6.62e-12

Myosin N-terminal SH3-like domain; This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.


Pssm-ID: 460670  Cd Length: 45  Bit Score: 61.68  E-value: 6.62e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2462555497   33 DAKTYCFVVDSKEEYAKGKIKSSQDGKVTVETEDNRTLVVKPEDV 77
Cdd:pfam02736    1 DAKKLVWVPDPKEGFVKGEIKEEEGDKVTVETEDGKTVTVKKDDV 45
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
1246-1519 7.09e-12

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 70.65  E-value: 7.09e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1246 LEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENK 1325
Cdd:pfam09726  400 LEQDIKKLKAELQASRQTEQELRSQISSLTSLERSLKSELGQLRQENDLLQTKLHNAVSAKQKDKQTVQQLEKRLKAEQE 479
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1326 AKNALAHALQSSRhdcdllreQYEEEQEGKAELQRALSKANSevaqwrtKYETDAI-QRTEELEEAKKKLAQRLQDSEEQ 1404
Cdd:pfam09726  480 ARASAEKQLAEEK--------KRKKEEEATAARAVALAAASR-------GECTESLkQRKRELESEIKKLTHDIKLKEEQ 544
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1405 VEAVNAKCASLEKTKQRlQGEVEDLMvdveraNSLAAALDKKQrnfdkvlaewktkceesqaELEASLKESRSLSTELFk 1484
Cdd:pfam09726  545 IRELEIKVQELRKYKES-EKDTEVLM------SALSAMQDKNQ-------------------HLENSLSAETRIKLDLF- 597
                          250       260       270
                   ....*....|....*....|....*....|....*
gi 2462555497 1485 lkNAYEEALDQLETVKRENKNLEQEIADLTEQIAE 1519
Cdd:pfam09726  598 --SALGDAKRQLEIAQGQIYQKDQEIKDLKQKIAE 630
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1566-1932 4.06e-11

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 68.53  E-value: 4.06e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1566 LTQVKSEIDRK---------------IAEKDEEIEQLKRNYQRTVETMQSALD--AEVRSRNEAIrlkKKMEGDLNEIEI 1628
Cdd:PRK02224   189 LDQLKAQIEEKeekdlherlngleseLAELDEEIERYEEQREQARETRDEADEvlEEHEERREEL---ETLEAEIEDLRE 265
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1629 QLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQE-DLKEQLAIVERRANLlQAEVEELRATLEQTERARKLAEQEL 1707
Cdd:PRK02224   266 TIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGlDDADAEAVEARREEL-EDRDEELRDRLEECRVAAQAHNEEA 344
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1708 LDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDAS----------RDARNAEEKAKKAITDAAMMAEELKKEQDts 1777
Cdd:PRK02224   345 ESLREDADDLEERAEELREEAAELESELEEAREAVEDRReeieeleeeiEELRERFGDAPVDLGNAEDFLEELREERD-- 422
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1778 aHLERMKKNLEQTVKDLQHRLDEAEQLaLKGGK---------------------KQIQKLETRIRELEFELEgEQKKNTE 1836
Cdd:PRK02224   423 -ELREREAELEATLRTARERVEEAEAL-LEAGKcpecgqpvegsphvetieedrERVEELEAELEDLEEEVE-EVEERLE 499
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1837 SVKGLRKYERRVKELtyqsEEDRKNVlrlQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAES 1916
Cdd:PRK02224   500 RAEDLVEAEDRIERL----EERREDL---EELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEARE 572
                          410
                   ....*....|....*.
gi 2462555497 1917 QVNKLRAKTRDFTSSR 1932
Cdd:PRK02224   573 EVAELNSKLAELKERI 588
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
841-1724 5.90e-11

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 67.89  E-value: 5.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  841 LKSAETEKEmatmkeefqktkdelakseakRKELEEKLvtlvqekNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKI 920
Cdd:pfam01576  419 ARLSESERQ---------------------RAELAEKL-------SKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQL 470
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  921 KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKAL 1000
Cdd:pfam01576  471 QDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRL 550
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1001 QEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLegDLKLAQESILDLendkQQLDER 1080
Cdd:pfam01576  551 QRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKF--DQMLAEEKAISA----RYAEER 624
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1081 lkkkdfeycqlqskvedeqtlglqfqkkikelqarieeleeeieaeraTRAKTEKqrsdyareleelserleeaggvtst 1160
Cdd:pfam01576  625 ------------------------------------------------DRAEAEA------------------------- 631
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1161 qielnKKREAEFLKLRRDLEEATlqheamvatlrkkhadsvaelgEQIDNLQRVKQKLekeksefKLEIDDLSSSMESVS 1240
Cdd:pfam01576  632 -----REKETRALSLARALEEAL----------------------EAKEELERTNKQL-------RAEMEDLVSSKDDVG 677
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1241 KSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEekesivsqlsRSKQAFTQQTEELKRQL 1320
Cdd:pfam01576  678 KNVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQFE----------RDLQARDEQGEEKRRQL 747
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1321 EEEnkaknalahalqssrhdcdlLRE-QYEEEQEGKaelQRALSKAnsevaqwrtkyetdaiqrteeleeAKKKLAQRLQ 1399
Cdd:pfam01576  748 VKQ--------------------VRElEAELEDERK---QRAQAVA------------------------AKKKLELDLK 780
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1400 DSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSlaaaldkkqrnfdkvlaewktkceeSQAELEASLKESRSls 1479
Cdd:pfam01576  781 ELEAQIDAANKGREEAVKQLKKLQAQMKDLQRELEEARA-------------------------SRDEILAQSKESEK-- 833
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1480 telfKLKNAYEEAL---DQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEE 1556
Cdd:pfam01576  834 ----KLKNLEAELLqlqEDLAASERARRQAQQERDELADEIASGASGKSALQDEKRRLEARIAQLEEELEEEQSNTELLN 909
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1557 AKILRIQLELTQVKSEI--DRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAirLKKKMEGDLNEIEIQLSHAN 1634
Cdd:pfam01576  910 DRLRKSTLQVEQLTTELaaERSTSQKSESARQQLERQNKELKAKLQEMEGTVKSKFKS--SIAALEAKIAQLEEQLEQES 987
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1635 RQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERV 1714
Cdd:pfam01576  988 RERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQRELDDATESN 1067
                          890
                   ....*....|
gi 2462555497 1715 QLLHTQNTSL 1724
Cdd:pfam01576 1068 ESMNREVSTL 1077
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1255-1709 6.09e-11

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 67.49  E-value: 6.09e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1255 DQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFT--QQTEELKRQLEEENKAKNALAH 1332
Cdd:COG4717     74 KELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPlyQELEALEAELAELPERLEELEE 153
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1333 ALQSSRHdcdlLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKC 1412
Cdd:COG4717    154 RLEELRE----LEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEEL 229
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1413 ASLEKTKQRLQ-----GEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKN 1487
Cdd:COG4717    230 EQLENELEAAAleerlKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQA 309
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1488 AYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEheeakilriqLELT 1567
Cdd:COG4717    310 LPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAAL----------LAEA 379
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1568 QVKSEID-RKIAEKDEEIEQLKRnyqrTVETMQSALDAEVRSRNEAIRlkkkmEGDLNEIEIQLSHANRQAAETLKHLRS 1646
Cdd:COG4717    380 GVEDEEElRAALEQAEEYQELKE----ELEELEEQLEELLGELEELLE-----ALDEEELEEELEELEEELEELEEELEE 450
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462555497 1647 VQGQLKDTQLHLDDALRGQE--DLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLD 1709
Cdd:COG4717    451 LREELAELEAELEQLEEDGElaELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLP 515
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1444-1925 9.40e-11

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 67.37  E-value: 9.40e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1444 DKKQRNFDKVLAEWKTKCEESQAEL---EASLKESRSLSTELFKLKNAYEEALDQLETvkrenknLEQEIADLTEQIAEN 1520
Cdd:PRK02224   198 EKEEKDLHERLNGLESELAELDEEIeryEEQREQARETRDEADEVLEEHEERREELET-------LEAEIEDLRETIAET 270
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1521 GKT-------IHELEKSRKQIELEKADIQLALEEAEAALEHeeakilriqleLTQVKSEIDRKIAEKDEEIEQLKRNYQR 1593
Cdd:PRK02224   271 EREreelaeeVRDLRERLEELEEERDDLLAEAGLDDADAEA-----------VEARREELEDRDEELRDRLEECRVAAQA 339
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1594 TVETMQSALD--AEVRSRNEAIRLK-KKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKE 1670
Cdd:PRK02224   340 HNEEAESLREdaDDLEERAEELREEaAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELRE 419
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1671 QLAIVERRANLLQAEVEELRATLEQTER---ARKLAE--QELLDSnERVQLLHTQNTSlihtKKKLETDLMQLQSEVEDa 1745
Cdd:PRK02224   420 ERDELREREAELEATLRTARERVEEAEAlleAGKCPEcgQPVEGS-PHVETIEEDRER----VEELEAELEDLEEEVEE- 493
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1746 sRDARNAEekakkaitdaammAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQlalkggkkQIQKLETRIRELEF 1825
Cdd:PRK02224   494 -VEERLER-------------AEDLVEAEDRIERLEERREDLEELIAERRETIEEKRE--------RAEELRERAAELEA 551
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1826 ELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDkLQVKVKSYKRQAE----------EADEQANAHLT 1895
Cdd:PRK02224   552 EAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRT-LLAAIADAEDEIErlrekrealaELNDERRERLA 630
                          490       500       510
                   ....*....|....*....|....*....|
gi 2462555497 1896 KFRKAQHELEEAEERADIAESQVNKLRAKT 1925
Cdd:PRK02224   631 EKRERKRELEAEFDEARIEEAREDKERAEE 660
PTZ00121 PTZ00121
MAEBL; Provisional
1344-1920 9.85e-11

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 67.47  E-value: 9.85e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1344 LREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNaKCASLEKTKQRLQ 1423
Cdd:PTZ00121  1099 KAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDAR-KAEEARKAEDAKK 1177
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1424 GEVEDLMVDVERANSLAAALDKKQrnfdkvlAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKREN 1503
Cdd:PTZ00121  1178 AEAARKAEEVRKAEELRKAEDARK-------AEAARKAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERN 1250
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1504 KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEE 1583
Cdd:PTZ00121  1251 NEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKK 1330
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1584 IEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDlneiEIQLSHANRQAAETLKHLRSVQgQLKDTQLHLDDALR 1663
Cdd:PTZ00121  1331 ADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAA----EKKKEEAKKKADAAKKKAEEKK-KADEAKKKAEEDKK 1405
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1664 GQEDLKEQLAiVERRANLLQAEVEELRatleQTERARKLAEQelldsnervqllhtqntslihtKKKLEtdlmqlqsEVE 1743
Cdd:PTZ00121  1406 KADELKKAAA-AKKKADEAKKKAEEKK----KADEAKKKAEE----------------------AKKAD--------EAK 1450
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1744 DASRDARNAEEKAKKAitDAAMMAEELKKEQDTSAHLERMKKNLEQTVK---------DLQHRLDEAEQLALKGGKKQIQ 1814
Cdd:PTZ00121  1451 KKAEEAKKAEEAKKKA--EEAKKADEAKKKAEEAKKADEAKKKAEEAKKkadeakkaaEAKKKADEAKKAEEAKKADEAK 1528
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1815 KLETRIRELEFELEGEQKKNTESVKG--LRKYERRVK-ELTYQSEEDRKNVLRLQDLVDKLQVK---------VKSYKRQ 1882
Cdd:PTZ00121  1529 KAEEAKKADEAKKAEEKKKADELKKAeeLKKAEEKKKaEEAKKAEEDKNMALRKAEEAKKAEEArieevmklyEEEKKMK 1608
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|
gi 2462555497 1883 AEEA--DEQANAHLTKFRKAQHELEEAEERADIAESQVNK 1920
Cdd:PTZ00121  1609 AEEAkkAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKK 1648
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1344-1923 1.73e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 66.22  E-value: 1.73e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1344 LREQYEEEQEgkAELQRALSKANSEVAqwrtkyETDAIqrTEELEEAKKKLAQRLQDSEEqveavnakcaSLEKTKQRLQ 1423
Cdd:PRK02224   192 LKAQIEEKEE--KDLHERLNGLESELA------ELDEE--IERYEEQREQARETRDEADE----------VLEEHEERRE 251
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1424 gEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESrslstelfKLKNAYEEAL-DQLETVKRE 1502
Cdd:PRK02224   252 -ELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEA--------GLDDADAEAVeARREELEDR 322
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1503 NKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEeaeaaleheeakilRIQLELTQVKSEIDR---KIAE 1579
Cdd:PRK02224   323 DEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAA--------------ELESELEEAREAVEDrreEIEE 388
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1580 KDEEIEQLKRNYQRTVETMQSALD--AEVRSRNEAIRlkkkmeGDLNEIEIQLSHANRQAAETLKHLRSVQ----GQLKD 1653
Cdd:PRK02224   389 LEEEIEELRERFGDAPVDLGNAEDflEELREERDELR------EREAELEATLRTARERVEEAEALLEAGKcpecGQPVE 462
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1654 TQLHLDDAlrgqEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQ--ELLDSNERV-QLLHTQNTSLIHTKKK 1730
Cdd:PRK02224   463 GSPHVETI----EEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEAEDRieRLEERREDLeELIAERRETIEEKRER 538
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1731 LETdlmqLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEqTVKDLQHRLDEAEQlalkggk 1810
Cdd:PRK02224   539 AEE----LRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLE-RIRTLLAAIADAED------- 606
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1811 kqiqkletRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQ-DLVDKLQVKVKSYKRQAEEADEQ 1889
Cdd:PRK02224   607 --------EIERLREKREALAELNDERRERLAEKRERKRELEAEFDEARIEEAREDkERAEEYLEQVEEKLDELREERDD 678
                          570       580       590
                   ....*....|....*....|....*....|....
gi 2462555497 1890 ANAHLTKFRKAQHELEEAEERADIAESQVNKLRA 1923
Cdd:PRK02224   679 LQAEIGAVENELEELEELRERREALENRVEALEA 712
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1054-1692 2.47e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 65.83  E-value: 2.47e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1054 RKLEGDLKLAQESILDlenDKQQLDERLKKkdfeycQLQSKVEDEQTLGLQ-FQKKIKELQARIEeleeeieaeratrak 1132
Cdd:PRK02224   168 RERASDARLGVERVLS---DQRGSLDQLKA------QIEEKEEKDLHERLNgLESELAELDEEIE--------------- 223
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1133 tekqrsdyareleelserleeaggvtstqiELNKKREaeflKLRRDLEEATLQHEAMVATLrkkhaDSVAELGEQIDNLQ 1212
Cdd:PRK02224   224 ------------------------------RYEEQRE----QARETRDEADEVLEEHEERR-----EELETLEAEIEDLR 264
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1213 RVKQKLEKEKSEFKLEIDDLSSSMEsvskskanlekicrTLEDQLSEARGKNEeiqrsLSELTTQKSRLQTEagELSRQL 1292
Cdd:PRK02224   265 ETIAETEREREELAEEVRDLRERLE--------------ELEEERDDLLAEAG-----LDDADAEAVEARRE--ELEDRD 323
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1293 EEKESIVSQLSRSKQAFTQQTEELkrqleeenkaknalahalqssRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQW 1372
Cdd:PRK02224   324 EELRDRLEECRVAAQAHNEEAESL---------------------REDADDLEERAEELREEAAELESELEEAREAVEDR 382
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1373 RTkyetdaiqRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVEranSLAAALDKKQRNF-- 1450
Cdd:PRK02224   383 RE--------EIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLR---TARERVEEAEALLea 451
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1451 -----------DKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYE---EALDQLETVKRENKNLEQEIADLTEQ 1516
Cdd:PRK02224   452 gkcpecgqpveGSPHVETIEEDRERVEELEAELEDLEEEVEEVEERLERAEdlvEAEDRIERLEERREDLEELIAERRET 531
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1517 IAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDR--KIAEKDEEIEQLKRNYQRT 1594
Cdd:PRK02224   532 IEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESleRIRTLLAAIADAEDEIERL 611
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1595 VETMQ--SALDAEVRSRNEAIRLKKK-MEGDLNEIEIQLSHANRQAAET--------LKHLRSVQGQLKDTQLHLDDALR 1663
Cdd:PRK02224   612 REKREalAELNDERRERLAEKRERKReLEAEFDEARIEEAREDKERAEEyleqveekLDELREERDDLQAEIGAVENELE 691
                          650       660       670
                   ....*....|....*....|....*....|..
gi 2462555497 1664 GQEDLKEQLAIVERRANLLQA---EVEELRAT 1692
Cdd:PRK02224   692 ELEELRERREALENRVEALEAlydEAEELESM 723
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
1202-1743 3.05e-10

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 65.15  E-value: 3.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1202 AELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRL 1281
Cdd:pfam05557    2 AELIESKARLSQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRLK 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1282 QTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRA 1361
Cdd:pfam05557   82 KKYLEALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQ 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1362 LSKAnsevaqwrtkyeTDAIQRTEELEeakKKLAQRLQDSEEqVEAVNAKCAS---LEKTKQRLQGEVEDL---MVDVER 1435
Cdd:pfam05557  162 QSSL------------AEAEQRIKELE---FEIQSQEQDSEI-VKNSKSELARipeLEKELERLREHNKHLnenIENKLL 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1436 ANSLAAALDKKQRNFDKVLAEwKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTE 1515
Cdd:pfam05557  226 LKEEVEDLKRKLEREEKYREE-AATLELEKEKLEQELQSWVKLAQDTGLNLRSPEDLSRRIEQLQQREIVLKEENSSLTS 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1516 QiaengktIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRkiaekdeeIEQLKRNYQRTV 1595
Cdd:pfam05557  305 S-------ARQLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDG--------YRAILESYDKEL 369
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1596 eTMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKdtqlhlddALRGQEDLKEQLAIV 1675
Cdd:pfam05557  370 -TMSNYSPQLLERIEEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERELQ--------ALRQQESLADPSYSK 440
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462555497 1676 ERRANLLQaEVEELRATLEQTERARKLAEQEL--------LDSNERVQLLHTQNTSLIHTKKKLEtDLMQLQSEVE 1743
Cdd:pfam05557  441 EEVDSLRR-KLETLELERQRLREQKNELEMELerrclqgdYDPKKTKVLHLSMNPAAEAYQQRKN-QLEKLQAEIE 514
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
990-1369 4.45e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 65.08  E-value: 4.45e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  990 IAKLTREKKALQEAHQQALDDLQAE----EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQE 1065
Cdd:TIGR02168  661 ITGGSAKTNSSILERRREIEELEEKieelEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEA 740
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1066 SILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQrsdyarele 1145
Cdd:TIGR02168  741 EVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAE--------- 811
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1146 elserleeaggVTSTQIELNKKREAEfLKLRRDLEEATLQHEAMVATLRKKhADSVAELGEQIDNLQRVKQKLEKEKSEF 1225
Cdd:TIGR02168  812 -----------LTLLNEEAANLRERL-ESLERRIAATERRLEDLEEQIEEL-SEDIESLAAEIEELEELIEELESELEAL 878
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1226 KLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQ-LSR 1304
Cdd:TIGR02168  879 LNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEeAEA 958
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462555497 1305 SKQAFTQQTEELKRQLEEENKAKNAL---------AHALQSSRHDcdLLREQYEEEQEGKAELQRALSKANSEV 1369
Cdd:TIGR02168  959 LENKIEDDEEEARRRLKRLENKIKELgpvnlaaieEYEELKERYD--FLTAQKEDLTEAKETLEEAIEEIDREA 1030
PTZ00121 PTZ00121
MAEBL; Provisional
836-1269 5.08e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 65.16  E-value: 5.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  836 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQA--ESENLLDAEERCDQLIKAK 913
Cdd:PTZ00121  1511 KADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAkkAEEDKNMALRKAEEAKKAE 1590
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  914 fqlEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDiddlELTLAKVEKEKHATENKVKNLTEELSGLDETIAKL 993
Cdd:PTZ00121  1591 ---EARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKA----EEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKA 1663
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  994 TREKKALQEAHQQALDDLQAEEDKvnslnktkSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEND 1073
Cdd:PTZ00121  1664 AEEAKKAEEDKKKAEEAKKAEEDE--------KKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEA 1735
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1074 KQQLDERLKKKDfeycqlQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRS--DYARELEELSERL 1151
Cdd:PTZ00121  1736 KKEAEEDKKKAE------EAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMevDKKIKDIFDNFAN 1809
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1152 EEAGGVTSTQIeLNKKREAEFLKLR---------RDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 1222
Cdd:PTZ00121  1810 IIEGGKEGNLV-INDSKEMEDSAIKevadsknmqLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEAD 1888
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*..
gi 2462555497 1223 SEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQR 1269
Cdd:PTZ00121  1889 EIEKIDKDDIEREIPNNNMAGKNNDIIDDKLDKDEYIKRDAEETREE 1935
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
841-1076 7.11e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 64.32  E-value: 7.11e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  841 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKI 920
Cdd:TIGR02169  777 LEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEI 856
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  921 KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKAL 1000
Cdd:TIGR02169  857 ENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEI 936
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1001 QEAHQQALDDLQAEEDkVNSLNKTKSKLEQQVEDLES-------SLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEND 1073
Cdd:TIGR02169  937 EDPKGEDEEIPEEELS-LEDVQAELQRVEEEIRALEPvnmlaiqEYEEVLKRLDELKEKRAKLEEERKAILERIEEYEKK 1015

                   ...
gi 2462555497 1074 KQQ 1076
Cdd:TIGR02169 1016 KRE 1018
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
842-1425 7.76e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 64.29  E-value: 7.76e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  842 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD-AEERCDQLIKAKFqleaki 920
Cdd:PRK02224   231 QARETRDEADEVLEEHEERREELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEElEEERDDLLAEAGL------ 304
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  921 kevtERAEDEeeinaeltakkrKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKAL 1000
Cdd:PRK02224   305 ----DDADAE------------AVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAEL 368
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1001 QEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKlaqesilDLENDKQQLDER 1080
Cdd:PRK02224   369 ESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREA-------ELEATLRTARER 441
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1081 LKkkdfeycqlqskvEDEQtlgLQFQKKIKELQARIEEleeeieaeratraktekqrsdyareleelserleeaggvtST 1160
Cdd:PRK02224   442 VE-------------EAEA---LLEAGKCPECGQPVEG----------------------------------------SP 465
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1161 QIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKkhADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVS 1240
Cdd:PRK02224   466 HVETIEEDRERVEELEAELEDLEEEVEEVEERLER--AEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELR 543
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1241 KSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSR------QLEEKESIVSQLSRSKQAFTQQTE 1314
Cdd:PRK02224   544 ERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERirtllaAIADAEDEIERLREKREALAELND 623
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1315 ELKRQLEEENKAKNALAHALQSSRhdcdllreqYEEEQEGKAELQRALSKANSEVAQWRTkyETDAIQRT--------EE 1386
Cdd:PRK02224   624 ERRERLAEKRERKRELEAEFDEAR---------IEEAREDKERAEEYLEQVEEKLDELRE--ERDDLQAEigavenelEE 692
                          570       580       590
                   ....*....|....*....|....*....|....*....
gi 2462555497 1387 LEEAKKKLAQrLQDSEEQVEAVNAKCASLEKTKQRLQGE 1425
Cdd:PRK02224   693 LEELRERREA-LENRVEALEALYDEAEELESMYGDLRAE 730
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
845-1519 1.10e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 63.59  E-value: 1.10e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  845 ETEKEMATMKEEFQKTKDELAKSEAKR---KELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAkfqleakIK 921
Cdd:pfam05483  128 ENEKVSLKLEEEIQENKDLIKENNATRhlcNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILA-------FE 200
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  922 EVTERAEDEE-EINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLtREKKAL 1000
Cdd:pfam05483  201 ELRVQAENARlEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKANQL-EEKTKL 279
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1001 QEahqqalddlqaeeDKVNSLNKTKSKLEQQVEDLESSLEQEKKlrvdlerNKRKLEGDLKLAQESILDLENDKQQLDER 1080
Cdd:pfam05483  280 QD-------------ENLKELIEKKDHLTKELEDIKMSLQRSMS-------TQKALEEDLQIATKTICQLTEEKEAQMEE 339
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1081 LKKKDFEY-----------CQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSE 1149
Cdd:pfam05483  340 LNKAKAAHsfvvtefeattCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELEELKKILAEDEK 419
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1150 RLEEAGGVTSTQIELN-KKREAEFLKLRRDLEEATLQHEAMVATLRKKHadsvaelgeQIDNLQRVKQKLEKEK---SEF 1225
Cdd:pfam05483  420 LLDEKKQFEKIAEELKgKEQELIFLLQAREKEIHDLEIQLTAIKTSEEH---------YLKEVEDLKTELEKEKlknIEL 490
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1226 KLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVsqlsrs 1305
Cdd:pfam05483  491 TAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEV------ 564
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1306 kQAFTQQTEELKRQLEEENKAKNALAHALQSSrhdCDLLREQYEEEQEGKAELQ---RALSKANSEVAQWRTKYETDAIQ 1382
Cdd:pfam05483  565 -KCKLDKSEENARSIEYEVLKKEKQMKILENK---CNNLKKQIENKNKNIEELHqenKALKKKGSAENKQLNAYEIKVNK 640
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1383 RTEELEEAKKKLAQRLQDSEEQVEAVNAkcaslekTKQRLQGEVEDLMVDVERANSLAAALDKK---------------Q 1447
Cdd:pfam05483  641 LELELASAKQKFEEIIDNYQKEIEDKKI-------SEEKLLEEVEKAKAIADEAVKLQKEIDKRcqhkiaemvalmekhK 713
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462555497 1448 RNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAE 1519
Cdd:pfam05483  714 HQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENTAILKD 785
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1201-1596 1.13e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 63.25  E-value: 1.13e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1201 VAELGEQIDNLQRVK-QKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKIcRTLEDQLSEARGKNEEIQRSLSELTTQKS 1279
Cdd:COG4717     48 LERLEKEADELFKPQgRKPELNLKELKELEEELKEAEEKEEEYAELQEEL-EELEEELEELEAELEELREELEKLEKLLQ 126
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1280 RLQT--EAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQ----SSRHDCDLLREQYEEEQE 1353
Cdd:COG4717    127 LLPLyqELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEqlslATEEELQDLAEELEELQQ 206
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1354 GKAELQRALSKANSEVAQwrTKYETDAIQRTEELEEAKKKLAQRLQ---------------------------------- 1399
Cdd:COG4717    207 RLAELEEELEEAQEELEE--LEEELEQLENELEAAALEERLKEARLllliaaallallglggsllsliltiagvlflvlg 284
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1400 --------------DSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTkcEESQ 1465
Cdd:COG4717    285 llallflllarekaSLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEE--LEEE 362
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1466 AELEASLKESRSLsteLFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEK--SRKQIELEKADIQL 1543
Cdd:COG4717    363 LQLEELEQEIAAL---LAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEalDEEELEEELEELEE 439
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462555497 1544 ALEEAEAALEHEEAKILRIQLELTQVKSeiDRKIAEKDEEIEQLKRNYQRTVE 1596
Cdd:COG4717    440 ELEELEEELEELREELAELEAELEQLEE--DGELAELLQELEELKAELRELAE 490
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
847-1393 1.25e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 63.50  E-value: 1.25e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTER 926
Cdd:TIGR04523   81 EQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNK 160
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  927 AEDEEEINAELTAKKRKLEDECSELKKDIDD-------LELTLAKVEK--EKHAT-ENKVKNLTEELSGLDETIAKLTRE 996
Cdd:TIGR04523  161 YNDLKKQKEELENELNLLEKEKLNIQKNIDKiknkllkLELLLSNLKKkiQKNKSlESQISELKKQNNQLKDNIEKKQQE 240
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  997 ----KKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLER-NKRKLEGDLKLAQESILDLE 1071
Cdd:TIGR04523  241 inekTTEISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDlNNQKEQDWNKELKSELKNQE 320
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1072 NDKQQLDERLKKKDFEYCQLQSKVEdeqtlglQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERL 1151
Cdd:TIGR04523  321 KKLEEIQNQISQNNKIISQLNEQIS-------QLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQI 393
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1152 EEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATlRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDD 1231
Cdd:TIGR04523  394 NDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKET-IIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKV 472
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1232 LsssmesvsksKANLEKICRTLEDQLSEARGKNEEiqrsLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQ 1311
Cdd:TIGR04523  473 L----------SRSINKIKQNLEQKQKELKSKEKE----LKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKES 538
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1312 QTEELKRQLEE--ENKAKNALAHALQSSRHDCDLLREQYEE---EQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEE 1386
Cdd:TIGR04523  539 KISDLEDELNKddFELKKENLEKEIDEKNKEIEELKQTQKSlkkKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKE 618

                   ....*..
gi 2462555497 1387 LEEAKKK 1393
Cdd:TIGR04523  619 LEKAKKE 625
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1278-1905 1.75e-09

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 62.82  E-value: 1.75e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1278 KSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLRE----------Q 1347
Cdd:pfam05483   94 KVSIEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHLCNLLKEtcarsaektkK 173
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1348 YEEEQEGK----AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQ 1423
Cdd:pfam05483  174 YEYEREETrqvyMDLNNNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKE 253
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1424 GEVEDLMVDVERANSLAAALDKKQRNFDKVLAEwktkceesqaeleaSLKESRSLSTELFKLKNAYEEALDQLETVKREN 1503
Cdd:pfam05483  254 NKMKDLTFLLEESRDKANQLEEKTKLQDENLKE--------------LIEKKDHLTKELEDIKMSLQRSMSTQKALEEDL 319
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1504 KNLEQEIADLTEqiaENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKdEE 1583
Cdd:pfam05483  320 QIATKTICQLTE---EKEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSEL-EE 395
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1584 IEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEgdlneieiqlshanrqaaetlkhlrSVQGQLKDTQLHLDDALR 1663
Cdd:pfam05483  396 MTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAE-------------------------ELKGKEQELIFLLQAREK 450
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1664 GQEDLKEQLAIVERRANLLQAEVEELRATLEQteraRKLAEQELLDSNERVQL----LHTQNTSLIHTKKKLETDLMQLQ 1739
Cdd:pfam05483  451 EIHDLEIQLTAIKTSEEHYLKEVEDLKTELEK----EKLKNIELTAHCDKLLLenkeLTQEASDMTLELKKHQEDIINCK 526
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1740 SEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQD-TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGG--KKQIQKL 1816
Cdd:pfam05483  527 KQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDeVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNnlKKQIENK 606
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1817 ETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKnvlRLQDLVDKLQVKVKSYKRQAE---EADEQANAH 1893
Cdd:pfam05483  607 NKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQ---KFEEIIDNYQKEIEDKKISEEkllEEVEKAKAI 683
                          650
                   ....*....|..
gi 2462555497 1894 LTKFRKAQHELE 1905
Cdd:pfam05483  684 ADEAVKLQKEID 695
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1215-1442 2.03e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 61.70  E-value: 2.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1215 KQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEE 1294
Cdd:COG4942     22 AAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEA 101
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1295 KESIVSQLSRSKQAfTQQTEELKRQLEEENkaKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRT 1374
Cdd:COG4942    102 QKEELAELLRALYR-LGRQPPLALLLSPED--FLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEA 178
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462555497 1375 KYETDAIQRtEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAA 1442
Cdd:COG4942    179 LLAELEEER-AALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
845-1230 2.64e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 62.35  E-value: 2.64e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  845 ETEKEMATMKEEFQKTKD-------ELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAE------------SENLLDAEER 905
Cdd:TIGR04523  250 NTQTQLNQLKDEQNKIKKqlsekqkELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDwnkelkselknqEKKLEEIQNQ 329
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  906 CDQLIKAKFQLEAKI----KEVTERAEDEEEINAELTAKKRKLEDecseLKKDIDDLELTLAKVEKEKHATENKVKNLTE 981
Cdd:TIGR04523  330 ISQNNKIISQLNEQIsqlkKELTNSESENSEKQRELEEKQNEIEK----LKKENQSYKQEIKNLESQINDLESKIQNQEK 405
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  982 ELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLK 1061
Cdd:TIGR04523  406 LNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLE 485
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1062 LAQES-------ILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQarieeLEEEIEAERATRAKTE 1134
Cdd:TIGR04523  486 QKQKElkskekeLKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLE-----DELNKDDFELKKENLE 560
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1135 KQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEAT---LQHEAMVATLRKKHadsvAELGEQIDNL 1211
Cdd:TIGR04523  561 KEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEkkiSSLEKELEKAKKEN----EKLSSIIKNI 636
                          410
                   ....*....|....*....
gi 2462555497 1212 QRVKQKLEKEKSEFKLEID 1230
Cdd:TIGR04523  637 KSKKNKLKQEVKQIKETIK 655
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
840-1107 3.06e-09

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 62.15  E-value: 3.06e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  840 LLKSAETEKEMATMK-----EEFQKTKDELAKSEAKRKE-----LEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQL 909
Cdd:pfam10174  264 LLHTEDREEEIKQMEvykshSKFMKNKIDQLKQELSKKEsellaLQTKLETLTNQNSDCKQHIEVLKESLTAKEQRAAIL 343
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  910 ikakfqlEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDET 989
Cdd:pfam10174  344 -------QTEVDALRLRLEEKESFLNKKTKQLQDLTEEKSTLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQ 416
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  990 IAKLTREKKALQEAHQQA------LDDLQAEEDKV-NSLNKTKSKLEQQVEDLESSLEQEKKlrvDLERNKRKLEGDLKL 1062
Cdd:pfam10174  417 LAGLKERVKSLQTDSSNTdtalttLEEALSEKERIiERLKEQREREDRERLEELESLKKENK---DLKEKVSALQPELTE 493
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 2462555497 1063 AQESILDLENDKQQLDERLKKKDFEYCQL----QSKVEDEQTLGLQFQK 1107
Cdd:pfam10174  494 KESSLIDLKEHASSLASSGLKKDSKLKSLeiavEQKKEECSKLENQLKK 542
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
950-1318 3.13e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 62.38  E-value: 3.13e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  950 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLE 1029
Cdd:TIGR02168  674 ERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLS 753
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1030 QQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKI 1109
Cdd:TIGR02168  754 KELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRI 833
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1110 KELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAM 1189
Cdd:TIGR02168  834 AATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSEL 913
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1190 VATLRKKhADSVAELGEQIDNL-QRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKN---- 1264
Cdd:TIGR02168  914 RRELEEL-REKLAQLELRLEGLeVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGPVNlaai 992
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462555497 1265 ---EEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQlsRSKQAFTQQTEELKR 1318
Cdd:TIGR02168  993 eeyEELKERYDFLTAQKEDLTEAKETLEEAIEEIDREARE--RFKDTFDQVNENFQR 1047
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
848-1352 3.34e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 61.71  E-value: 3.34e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  848 KEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAES--ENLLDAEERCDQLIKAKFQLEAKIKEVTE 925
Cdd:COG4717     81 KEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPlyQELEALEAELAELPERLEELEERLEELRE 160
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  926 RAEDEEEINAELTAKKRKLEDECselkkdiddleltlakvEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQ 1005
Cdd:COG4717    161 LEEELEELEAELAELQEELEELL-----------------EQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELE 223
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1006 QalddlqaeedkvnslnktkskLEQQVEDLESSLEQEKklrvdLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKD 1085
Cdd:COG4717    224 E---------------------LEEELEQLENELEAAA-----LEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAG 277
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1086 FEYCQLQSKVedeqTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELN 1165
Cdd:COG4717    278 VLFLVLGLLA----LLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELL 353
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1166 KKREAEFLKLRRDLEEATLQheamvATLRKKHADSVAELGEQIDNLQRvKQKLEKEKSEFKLEIDDLS--SSMESVSKSK 1243
Cdd:COG4717    354 REAEELEEELQLEELEQEIA-----ALLAEAGVEDEEELRAALEQAEE-YQELKEELEELEEQLEELLgeLEELLEALDE 427
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1244 ANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEaGELSRQLEEKESIVSQLsrskqaftqqteelkRQLEEE 1323
Cdd:COG4717    428 EELEEELEELEEELEELEEELEELREELAELEAELEQLEED-GELAELLQELEELKAEL---------------RELAEE 491
                          490       500
                   ....*....|....*....|....*....
gi 2462555497 1324 NKAKNALAHALQSsrhdcdlLREQYEEEQ 1352
Cdd:COG4717    492 WAALKLALELLEE-------AREEYREER 513
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1385-1927 3.51e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 62.01  E-value: 3.51e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1385 EELEEAK-KKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKqrnfdkvlaeWKTKCEE 1463
Cdd:TIGR02169  218 KEKREYEgYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKK----------IKDLGEE 287
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1464 SQAELEASLkesRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQL 1543
Cdd:TIGR02169  288 EQLRVKEKI---GELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKE 364
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1544 ALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIaekdEEIEQLKRNYQRTVETMQSaLDAEVRSRNEAIrlkKKMEGDL 1623
Cdd:TIGR02169  365 ELEDLRAELEEVDKEFAETRDELKDYREKLEKLK----REINELKRELDRLQEELQR-LSEELADLNAAI---AGIEAKI 436
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1624 NEIEIQLShanrqaaETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRAT---LEQTERAR 1700
Cdd:TIGR02169  437 NELEEEKE-------DKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQaraSEERVRGG 509
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1701 KLAEQELLDSNERVqllHTQNTSLIHTKKKLETDLM-----QLQSEVEDASRDARNAEE--KAKKAitdAAMMAEELKKE 1773
Cdd:TIGR02169  510 RAVEEVLKASIQGV---HGTVAQLGSVGERYATAIEvaagnRLNNVVVEDDAVAKEAIEllKRRKA---GRATFLPLNKM 583
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1774 QDTSAHLERMKKN-----------------------LEQTVkdLQHRLDEAEQL------------------ALKGG--- 1809
Cdd:TIGR02169  584 RDERRDLSILSEDgvigfavdlvefdpkyepafkyvFGDTL--VVEDIEAARRLmgkyrmvtlegelfeksgAMTGGsra 661
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1810 -----------KKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVK- 1877
Cdd:TIGR02169  662 prggilfsrsePAELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEe 741
                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462555497 1878 -----SYKRQAEEADEQANAHLTK----FRKAQHELEEAEE--RADIAESQVNKLRAKTRD 1927
Cdd:TIGR02169  742 leedlSSLEQEIENVKSELKELEArieeLEEDLHKLEEALNdlEARLSHSRIPEIQAELSK 802
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1468-1936 5.86e-09

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 60.94  E-value: 5.86e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1468 LEASL-KESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALE 1546
Cdd:COG4717     47 LLERLeKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQ 126
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1547 EaeaaleheeakilriqLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVEtmqsaLDAEVRSRNEAIRlkkKMEGDLNEI 1626
Cdd:COG4717    127 L----------------LPLYQELEALEAELAELPERLEELEERLEELRE-----LEEELEELEAELA---ELQEELEEL 182
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1627 EIQLSHANRQaaetlkhlrsvqgQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQE 1706
Cdd:COG4717    183 LEQLSLATEE-------------ELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEAR 249
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1707 LLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKK--EQDTSAHLERMK 1784
Cdd:COG4717    250 LLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEEleEEELEELLAALG 329
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1785 KNLEQTVKDLQHRLDEAEQLalKGGKKQIQKLETRIRELEFELEGEQ---KKNTESVKGLR----------KYERRVKEL 1851
Cdd:COG4717    330 LPPDLSPEELLELLDRIEEL--QELLREAEELEEELQLEELEQEIAAllaEAGVEDEEELRaaleqaeeyqELKEELEEL 407
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1852 TYQSEEDRKNVLRLQDLVDK--LQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIA------ESQVNKLRA 1923
Cdd:COG4717    408 EEQLEELLGELEELLEALDEeeLEEELEELEEELEELEEELEELREELAELEAELEQLEEDGELAellqelEELKAELRE 487
                          490
                   ....*....|...
gi 2462555497 1924 KTRDFTSSRMVVH 1936
Cdd:COG4717    488 LAEEWAALKLALE 500
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1314-1924 1.48e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 59.93  E-value: 1.48e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1314 EELKRQLEEENKAKNALAHALQssrhdcdlLREQYEEEQEGKAELQRALSKANSEVAQwrTKYETdAIQRTEELEEAKKK 1393
Cdd:COG4913    238 ERAHEALEDAREQIELLEPIRE--------LAERYAAARERLAELEYLRAALRLWFAQ--RRLEL-LEAELEELRAELAR 306
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1394 LAQRLQDSEEQVEAVNAKCASLEKTKQRLQGE-VEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASL 1472
Cdd:COG4913    307 LEAELERLEARLDALREELDELEAQIRGNGGDrLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALR 386
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1473 KESR----SLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLteqiAENGKTI-HELEKSRKQI--ELEKADIQlal 1545
Cdd:COG4913    387 AEAAalleALEEELEALEEALAEAEAALRDLRRELRELEAEIASL----ERRKSNIpARLLALRDALaeALGLDEAE--- 459
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1546 eeaeaaleheeakiLRIQLELTQVKseidrkiaEKDEE----IEQLKRNYQRT--VEtmqSALDAEVRSRNEAIRLKKKM 1619
Cdd:COG4913    460 --------------LPFVGELIEVR--------PEEERwrgaIERVLGGFALTllVP---PEHYAAALRWVNRLHLRGRL 514
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1620 egDLNEIEIQLSHANRQAAETlkhlRSVQGQLkDTQLHlddALRGQedLKEQLAiveRRANLLQAE-VEELRA-----TL 1693
Cdd:COG4913    515 --VYERVRTGLPDPERPRLDP----DSLAGKL-DFKPH---PFRAW--LEAELG---RRFDYVCVDsPEELRRhpraiTR 579
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1694 E-QTERARKLAEQELLDSNERVQLLHTQNTSLIhtkKKLETDLMQLQSEVEDASRDARNAEEKAkkaitdaammaEELKK 1772
Cdd:COG4913    580 AgQVKGNGTRHEKDDRRRIRSRYVLGFDNRAKL---AALEAELAELEEELAEAEERLEALEAEL-----------DALQE 645
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1773 EQDTSAHLERMKKNlEQTVKDLQHRLDEAEQlalkggkkQIQKLET---RIRELEFELEGEQKKNTESVKGLRKYERRVK 1849
Cdd:COG4913    646 RREALQRLAEYSWD-EIDVASAEREIAELEA--------ELERLDAssdDLAALEEQLEELEAELEELEEELDELKGEIG 716
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462555497 1850 ELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEAD----EQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAK 1924
Cdd:COG4913    717 RLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERfaaaLGDAVERELRENLEERIDALRARLNRAEEELERAMRA 795
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1423-1924 1.72e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 59.69  E-value: 1.72e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1423 QGEVEDLMVDVERANSLAaaldKKQRNFDKVLAEWKtKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRE 1502
Cdd:PRK03918   134 QGEIDAILESDESREKVV----RQILGLDDYENAYK-NLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLRE 208
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1503 NKNLEQEIADLTEQIAENGKTIHELEKSRKqiELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDE 1582
Cdd:PRK03918   209 INEISSELPELREELEKLEKEVKELEELKE--EIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELK 286
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1583 EIEQLKRNYQRTVETMQSALDAEvrsrNEAIRLKKKMEGDLNEIEIQLSHANRQAAEtLKHLRSVQGQLKDTQLHLDDAL 1662
Cdd:PRK03918   287 ELKEKAEEYIKLSEFYEEYLDEL----REIEKRLSRLEEEINGIEERIKELEEKEER-LEELKKKLKELEKRLEELEERH 361
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1663 RGQEDLKEQLAIVER-RANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKL---------- 1731
Cdd:PRK03918   362 ELYEEAKAKKEELERlKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELkkakgkcpvc 441
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1732 -----ETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQtVKDLQHRLDEAEQLAL 1806
Cdd:PRK03918   442 greltEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQ-LKELEEKLKKYNLEEL 520
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1807 KGGKKQIQKLETRIRELEFELEGeQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRlqDLVDKLQVKVKSYKRQAEEA 1886
Cdd:PRK03918   521 EKKAEEYEKLKEKLIKLKGEIKS-LKKELEKLEELKKKLAELEKKLDELEEELAELLK--ELEELGFESVEELEERLKEL 597
                          490       500       510
                   ....*....|....*....|....*....|....*...
gi 2462555497 1887 DEQANAHLtKFRKAQHELEEAEERADIAESQVNKLRAK 1924
Cdd:PRK03918   598 EPFYNEYL-ELKDAEKELEREEKELKKLEEELDKAFEE 634
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1379-1706 1.93e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 59.70  E-value: 1.93e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1379 DAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLmvdvERANSLAAalDKKQRNFDKVLAEWK 1458
Cdd:TIGR02169  160 DEIAGVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKA----ERYQALLK--EKREYEGYELLKEKE 233
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1459 ---TKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNL--------EQEIADLTEQIAENGKTIHEL 1527
Cdd:TIGR02169  234 aleRQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLgeeeqlrvKEKIGELEAEIASLERSIAEK 313
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1528 EKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDE---EIEQLKRNYQRTVE---TMQSA 1601
Cdd:TIGR02169  314 ERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDlraELEEVDKEFAETRDelkDYREK 393
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1602 LDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANL 1681
Cdd:TIGR02169  394 LEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYD 473
                          330       340
                   ....*....|....*....|....*
gi 2462555497 1682 LQAEVEELRAtlEQTERARKLAEQE 1706
Cdd:TIGR02169  474 LKEEYDRVEK--ELSKLQRELAEAE 496
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
915-1300 2.85e-08

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 58.75  E-value: 2.85e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  915 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLT 994
Cdd:pfam07888   35 RLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEELS 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  995 REKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDK 1074
Cdd:pfam07888  115 EEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERMKERAKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKEF 194
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYAreleelserlEEA 1154
Cdd:pfam07888  195 QELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVEGLGEELS----------SMA 264
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1155 GGVTSTQIELNKKR-EAEFLKLRrdLEEATLQheamvatLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLS 1233
Cdd:pfam07888  265 AQRDRTQAELHQARlQAAQLTLQ--LADASLA-------LREGRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQ 335
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462555497 1234 SSMESVSKSKANL--EKICRTLedQLSEARGKNEEIQRSLSELTTQKSRLQTEAGEL---SRQLEEKESIVS 1300
Cdd:pfam07888  336 EERMEREKLEVELgrEKDCNRV--QLSESRRELQELKASLRVAQKEKEQLQAEKQELleyIRQLEQRLETVA 405
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1255-1471 3.06e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.85  E-value: 3.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1255 DQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHAL 1334
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1335 QSSRHD-CDLLREQYEEEQEGKAELqrALSKANSEVAQWRTKY----------ETDAIQRT-EELEEAKKKLAQRLQDSE 1402
Cdd:COG4942    100 EAQKEElAELLRALYRLGRQPPLAL--LLSPEDFLDAVRRLQYlkylaparreQAEELRADlAELAALRAELEAERAELE 177
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462555497 1403 EQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEAS 1471
Cdd:COG4942    178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
893-1513 3.12e-08

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 58.90  E-value: 3.12e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  893 QAESENLLDAEERCDQ-LIKAKFQLeAKIKEVTERAEDEEeinaelTAKKRKLEDE---CSELKKDIDDleltlaKVEKE 968
Cdd:PRK02224   137 QGEVNKLINATPSDRQdMIDDLLQL-GKLEEYRERASDAR------LGVERVLSDQrgsLDQLKAQIEE------KEEKD 203
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  969 KHATENKvknLTEELSGLDETI---------AKLTREKKALQ-EAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESS 1038
Cdd:PRK02224   204 LHERLNG---LESELAELDEEIeryeeqreqARETRDEADEVlEEHEERREELETLEAEIEDLRETIAETEREREELAEE 280
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1039 LEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKkkdfeycQLQSKVEDEQTLGLQFQKKIKELqariee 1118
Cdd:PRK02224   281 VRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDE-------ELRDRLEECRVAAQAHNEEAESL------ 347
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1119 leEEIEAERATRAKTEKQRSDyareleelserlEEAGGVTSTQIELNKKREAeflklRRDLEEAtlqheamVATLRKKHA 1198
Cdd:PRK02224   348 --REDADDLEERAEELREEAA------------ELESELEEAREAVEDRREE-----IEELEEE-------IEELRERFG 401
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1199 DSvaelGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKI-----CRTLE---------DQLSEARGKN 1264
Cdd:PRK02224   402 DA----PVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALleagkCPECGqpvegsphvETIEEDRERV 477
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1265 EEIQRSLSELTTQKSRLQ------TEAGELSRQ---LEEKESIVSQLSRSKQAFTQQTEElkrQLEEENKAKNALAHALQ 1335
Cdd:PRK02224   478 EELEAELEDLEEEVEEVEerleraEDLVEAEDRierLEERREDLEELIAERRETIEEKRE---RAEELRERAAELEAEAE 554
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1336 SSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAiqRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASL 1415
Cdd:PRK02224   555 EKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLLA--AIADAEDEIERLREKREALAELNDERRERLAEK 632
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1416 EKTKQRLQGEVEDlmvdveraNSLAAALDKKQRnfdkvlaewktkCEESQAELEASLKESRSLSTELFKLKNAYEEALDQ 1495
Cdd:PRK02224   633 RERKRELEAEFDE--------ARIEEAREDKER------------AEEYLEQVEEKLDELREERDDLQAEIGAVENELEE 692
                          650
                   ....*....|....*...
gi 2462555497 1496 LETVKRENKNLEQEIADL 1513
Cdd:PRK02224   693 LEELRERREALENRVEAL 710
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
1212-1910 5.29e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 58.52  E-value: 5.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1212 QRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ 1291
Cdd:TIGR00606  362 HIRARDSLIQSLATRLELDGFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRT 441
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1292 LEEKESI----VSQLSRSKQAFTQQTEELKRQLEEEN---KAKNALAHALQSSRHDCDLLREQYEeeQEGKAELQRALSK 1364
Cdd:TIGR00606  442 IELKKEIlekkQEELKFVIKELQQLEGSSDRILELDQelrKAERELSKAEKNSLTETLKKEVKSL--QNEKADLDRKLRK 519
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1365 ANSEVAQwrTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCAS-------LEKTKQRLQGEVEDLMVDVERAN 1437
Cdd:TIGR00606  520 LDQEMEQ--LNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGyfpnkkqLEDWLHSKSKEINQTRDRLAKLN 597
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1438 SLAAALDKKQRNFDKVLaEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI 1517
Cdd:TIGR00606  598 KELASLEQNKNHINNEL-ESKEEQLSSYEDKLFDVCGSQDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDEN 676
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1518 AENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQV-------KSEIDRKIAEKDE-------- 1582
Cdd:TIGR00606  677 QSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMlglapgrQSIIDLKEKEIPElrnklqkv 756
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1583 --EIEQLKRNYQRT---VETMQSALD-AEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL 1656
Cdd:TIGR00606  757 nrDIQRLKNDIEEQetlLGTIMPEEEsAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGSDLDRTVQQVNQEKQEKQH 836
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1657 HLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATL----EQTERARKLAEQELLDSNErVQLLHTQNTSLIHTKKKLE 1732
Cdd:TIGR00606  837 ELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKlqigTNLQRRQQFEEQLVELSTE-VQSLIREIKDAKEQDSPLE 915
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1733 TDLMQLQSEVEDAsrdARNAEEKAKKAITDAAMMAEELKK--------EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQl 1804
Cdd:TIGR00606  916 TFLEKDQQEKEEL---ISSKETSNKKAQDKVNDIKEKVKNihgymkdiENKIQDGKDDYLKQKETELNTVNAQLEECEK- 991
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1805 alkgGKKQIQKlETRIRELEFELEGEQKKNTESVKGLRKYERRVKEL-----TYQSEEDRKNVLRLQDLVDKLQVKVKSY 1879
Cdd:TIGR00606  992 ----HQEKINE-DMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVeeelkQHLKEMGQMQVLQMKQEHQKLEENIDLI 1066
                          730       740       750
                   ....*....|....*....|....*....|.
gi 2462555497 1880 KRQAEEADEQANAHLTKFRKAQHELEEAEER 1910
Cdd:TIGR00606 1067 KRNHVLALGRQKGYEKEIKHFKKELREPQFR 1097
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1385-1939 5.90e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 58.00  E-value: 5.90e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1385 EELEEAKkklaQRLQDSEEQVEA---VNAKCASLEKTKQRLQG-EVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTK 1460
Cdd:COG4913    235 DDLERAH----EALEDAREQIELlepIRELAERYAAARERLAElEYLRAALRLWFAQRRLELLEAELEELRAELARLEAE 310
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1461 CEESQAELEAslkesrsLSTELFKLKNAYEEA-LDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKA 1539
Cdd:COG4913    311 LERLEARLDA-------LREELDELEAQIRGNgGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFA 383
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1540 DIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKR---NYQRTVETMQSALDAEVRSRNEAIRLK 1616
Cdd:COG4913    384 ALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERrksNIPARLLALRDALAEALGLDEAELPFV 463
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1617 kkmeGDLneIEIQLSHAN-RQAAETlkhlrsvqgqlkdtqlhlddALRGQ--------EDLKEQLAIVERRAnllqaeve 1687
Cdd:COG4913    464 ----GEL--IEVRPEEERwRGAIER--------------------VLGGFaltllvppEHYAAALRWVNRLH-------- 509
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1688 eLRATLeQTERARKLAEQELLDSNERVQLLHtqntslihtkkKLETDLMQLQSEVED--ASRDA----RNAEE--KAKKA 1759
Cdd:COG4913    510 -LRGRL-VYERVRTGLPDPERPRLDPDSLAG-----------KLDFKPHPFRAWLEAelGRRFDyvcvDSPEElrRHPRA 576
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1760 ITDAAMMaeelkkeqdtsahlermKKNLEQTVKDLQHRLDE--------AEQLALKggKKQIQKLETRIRELEFELEgeq 1831
Cdd:COG4913    577 ITRAGQV-----------------KGNGTRHEKDDRRRIRSryvlgfdnRAKLAAL--EAELAELEEELAEAEERLE--- 634
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1832 kKNTESVKGLRKYERRVKELTYQSEED------RKNVLRLQDLVDKL---QVKVKSYKRQAEEADEQANAHLTKFRKAQH 1902
Cdd:COG4913    635 -ALEAELDALQERREALQRLAEYSWDEidvasaEREIAELEAELERLdasSDDLAALEEQLEELEAELEELEEELDELKG 713
                          570       580       590
                   ....*....|....*....|....*....|....*..
gi 2462555497 1903 ELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESE 1939
Cdd:COG4913    714 EIGRLEKELEQAEEELDELQDRLEAAEDLARLELRAL 750
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
888-1113 6.33e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 57.08  E-value: 6.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  888 LQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 967
Cdd:COG4942     11 LALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEK 90
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  968 EKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKtksKLEQQVEDLESSLEQEKKLRV 1047
Cdd:COG4942     91 EIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAP---ARREQAEELRADLAELAALRA 167
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1048 DLERNKRKLEGDLKLAQESILDLE---NDKQQLDERLKKKDFEY-CQLQSKVEDEQTLGLQFQKKIKELQ 1113
Cdd:COG4942    168 ELEAERAELEALLAELEEERAALEalkAERQKLLARLEKELAELaAELAELQQEAEELEALIARLEAEAA 237
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
845-1508 6.48e-08

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 58.00  E-value: 6.48e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  845 ETEKEMATMKEEfQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLdaEERCDQLIKAKFQLEAKIKEVT 924
Cdd:COG4913    239 RAHEALEDAREQ-IELLEPIRELAERYAAARERLAELEYLRAALRLWFAQRRLELL--EAELEELRAELARLEAELERLE 315
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  925 ERAEDEEEINAELTAKKRKLE-DECSELKKDIDDLELTLAKVEkekhateNKVKNLTEELSGLDETIAKLTREKKALQEA 1003
Cdd:COG4913    316 ARLDALREELDELEAQIRGNGgDRLEQLEREIERLERELEERE-------RRRARLEALLAALGLPLPASAEEFAALRAE 388
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1004 HQQALDDLQAEEDKvnsLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESIldlendKQQLDERLKK 1083
Cdd:COG4913    389 AAALLEALEEELEA---LEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDAL------AEALGLDEAE 459
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1084 KDF--EYCQLQSKVED-----EQTLGlqfqkkikelqarieeleeeieaeraTRAKTEKQRSDYARELEELSERLEEAGG 1156
Cdd:COG4913    460 LPFvgELIEVRPEEERwrgaiERVLG--------------------------GFALTLLVPPEHYAAALRWVNRLHLRGR 513
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1157 VTSTQIELNKKREaeflkLRRDLEEATLQHEamVATLRKKHADSV-AELGEQ--------IDNLQRVKQKLEKE---KSE 1224
Cdd:COG4913    514 LVYERVRTGLPDP-----ERPRLDPDSLAGK--LDFKPHPFRAWLeAELGRRfdyvcvdsPEELRRHPRAITRAgqvKGN 586
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1225 FKL-EIDDLSSSMESV------SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQT---------EAGEL 1288
Cdd:COG4913    587 GTRhEKDDRRRIRSRYvlgfdnRAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRlaeyswdeiDVASA 666
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1289 SRQLEEKESIVSQLSRSKQAFtqqtEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE 1368
Cdd:COG4913    667 EREIAELEAELERLDASSDDL----AALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDL 742
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1369 VAQWRTkYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCAS-LEKT----KQRLQGEVEDLMVDVERANSLAAAL 1443
Cdd:COG4913    743 ARLELR-ALLEERFAAALGDAVERELRENLEERIDALRARLNRAEEeLERAmrafNREWPAETADLDADLESLPEYLALL 821
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462555497 1444 DKKQRNfdkVLAEWKTKCEESQAELeaslkESRSLSTELFKLKNAYEEALDQLETVkreNKNLEQ 1508
Cdd:COG4913    822 DRLEED---GLPEYEERFKELLNEN-----SIEFVADLLSKLRRAIREIKERIDPL---NDSLKR 875
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
1320-1828 6.88e-08

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 57.39  E-value: 6.88e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1320 LEEENKAKNALAHAlqssrhdCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEeaKKKLAQRLQ 1399
Cdd:pfam05622    2 LSEAQEEKDELAQR-------CHELDQQVSLLQEEKNSLQQENKKLQERLDQLESGDDSGTPGGKKYLL--LQKQLEQLQ 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1400 DSEEQVEA----VNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVlaewktkceesqAELEASLKes 1475
Cdd:pfam05622   73 EENFRLETarddYRIKCEELEKEVLELQHRNEELTSLAEEAQALKDEMDILRESSDKV------------KKLEATVE-- 138
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1476 rslstelfklknAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHE 1555
Cdd:pfam05622  139 ------------TYKKKLEDLGDLRRQVKLLEERNAEYMQRTLQLEEELKKANALRGQLETYKRQVQELHGKLSEESKKA 206
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1556 EA---KILRIQLELTQVKSEIDRKIAEKD---EEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQ 1629
Cdd:pfam05622  207 DKlefEYKKLEEKLEALQKEKERLIIERDtlrETNEELRCAQLQQAELSQADALLSPSSDPGDNLAAEIMPAEIREKLIR 286
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1630 LSHANRqaAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLeqterarklaeqelld 1709
Cdd:pfam05622  287 LQHENK--MLRLGQEGSYRERLTELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQKAL---------------- 348
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1710 snervQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEEL-----KKEQDTSAHLERMK 1784
Cdd:pfam05622  349 -----QEQGSKAEDSSLLKQKLEEHLEKLHEAQSELQKKKEQIEELEPKQDSNLAQKIDELqealrKKDEDMKAMEERYK 423
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 2462555497 1785 KNLEQ---TVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELE 1828
Cdd:pfam05622  424 KYVEKaksVIKTLDPKQNPASPPEIQALKNQLLEKDKKIEHLERDFE 470
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
1278-1698 7.86e-08

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 57.21  E-value: 7.86e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1278 KSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAE 1357
Cdd:pfam07888   33 QNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEE 112
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1358 L---QRALSKANSEvaqwrtkyetdAIQRTEELEEAKKKLAQRLQDSEeqveavnakcASLEKTKQRlqgevedlmvdVE 1434
Cdd:pfam07888  113 LseeKDALLAQRAA-----------HEARIRELEEDIKTLTQRVLERE----------TELERMKER-----------AK 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1435 RANSLaaaldkkqrnfdkvLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLT 1514
Cdd:pfam07888  161 KAGAQ--------------RKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAH 226
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1515 EQIAENGKTIHELEKSRKQIELEkadiqlaleeaeaaleheeakilriQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRT 1594
Cdd:pfam07888  227 RKEAENEALLEELRSLQERLNAS-------------------------ERKVEGLGEELSSMAAQRDRTQAELHQARLQA 281
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1595 VETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQ-------------GQLKDTQL-HLDD 1660
Cdd:pfam07888  282 AQLTLQLADASLALREGRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQeermereklevelGREKDCNRvQLSE 361
                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 2462555497 1661 ALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTER 1698
Cdd:pfam07888  362 SRRELQELKASLRVAQKEKEQLQAEKQELLEYIRQLEQ 399
PTZ00121 PTZ00121
MAEBL; Provisional
1384-1940 8.67e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 57.84  E-value: 8.67e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1384 TEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKvLAEWKTKCEE 1463
Cdd:PTZ00121  1090 DEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIAR-KAEDARKAEE 1168
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1464 SQAELEASLKESRSLSTELFKlknayEEALDQLETVKRENKNLEQEIADLTEQI--AENGKTIHELEKS----RKQIELE 1537
Cdd:PTZ00121  1169 ARKAEDAKKAEAARKAEEVRK-----AEELRKAEDARKAEAARKAEEERKAEEArkAEDAKKAEAVKKAeeakKDAEEAK 1243
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1538 KADIQLALEEAEAALEHEEAKILRIQlelTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRS--RNEAIRL 1615
Cdd:PTZ00121  1244 KAEEERNNEEIRKFEEARMAHFARRQ---AAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAeeAKKADEA 1320
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1616 KKKMEgdlnEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRatleQ 1695
Cdd:PTZ00121  1321 KKKAE----EAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKK----K 1392
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1696 TERARKLAEQELLDSNErVQLLHTQNTSLIHTKKKLETdlMQLQSEVEDASRDARNAEEKAKKAitDAAMMAEELKKEQD 1775
Cdd:PTZ00121  1393 ADEAKKKAEEDKKKADE-LKKAAAAKKKADEAKKKAEE--KKKADEAKKKAEEAKKADEAKKKA--EEAKKAEEAKKKAE 1467
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1776 TSAHLERMKKNLEQTVKdlqhrLDEAEQLALKGGKK--QIQKLETRIRELEFELEGEQKKNTESVKglRKYERRVKELTY 1853
Cdd:PTZ00121  1468 EAKKADEAKKKAEEAKK-----ADEAKKKAEEAKKKadEAKKAAEAKKKADEAKKAEEAKKADEAK--KAEEAKKADEAK 1540
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1854 QSEEDRKnvlrLQDLVDKLQVKVKSYKRQAEEAdeqanahltkfrkaqhelEEAEERADIAESQVNKLRAKTRDFTSSRM 1933
Cdd:PTZ00121  1541 KAEEKKK----ADELKKAEELKKAEEKKKAEEA------------------KKAEEDKNMALRKAEEAKKAEEARIEEVM 1598

                   ....*..
gi 2462555497 1934 VVHESEE 1940
Cdd:PTZ00121  1599 KLYEEEK 1605
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
915-1141 8.84e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.70  E-value: 8.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  915 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDEcselkkdIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLT 994
Cdd:COG4942     24 EAEAELEQLQQEIAELEKELAALKKEEKALLKQ-------LAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  995 REKKALQEAHQQALDDLQaeedKVNSLNKTKSKLEQQ-VEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEND 1073
Cdd:COG4942     97 AELEAQKEELAELLRALY----RLGRQPPLALLLSPEdFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAE 172
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462555497 1074 KQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYA 1141
Cdd:COG4942    173 RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAA 240
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
863-1039 1.01e-07

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 54.93  E-value: 1.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  863 ELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTER-AEDEEEINAELTAKk 941
Cdd:COG1579     11 DLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARiKKYEEQLGNVRNNK- 89
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  942 rkledECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVnsl 1021
Cdd:COG1579     90 -----EYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEEL--- 161
                          170
                   ....*....|....*...
gi 2462555497 1022 nktKSKLEQQVEDLESSL 1039
Cdd:COG1579    162 ---EAEREELAAKIPPEL 176
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
832-1505 1.03e-07

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 57.36  E-value: 1.03e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  832 KLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSE--AKRKELEEKLVTLVQEKNDLQLQVQAESENL------LDAE 903
Cdd:TIGR00606  455 ELKFVIKELQQLEGSSDRILELDQELRKAERELSKAEknSLTETLKKEVKSLQNEKADLDRKLRKLDQEMeqlnhhTTTR 534
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  904 ERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDID-------DLELTLAKVEKEKHATENKV 976
Cdd:TIGR00606  535 TQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDWLHSKSKEINqtrdrlaKLNKELASLEQNKNHINNEL 614
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  977 KNLTEELSGLDETI----------AKLTREKKALQEAHQQalddLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLR 1046
Cdd:TIGR00606  615 ESKEEQLSSYEDKLfdvcgsqdeeSDLERLKEEIEKSSKQ----RAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTE 690
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1047 VDLERNKRKLEGDLKLAQESILDLENDkqqlderLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAE 1126
Cdd:TIGR00606  691 AELQEFISDLQSKLRLAPDKLKSTESE-------LKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRL 763
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1127 RATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELnKKREAEFLKLRRDLEEATLqhEAMVATLRKKHADSVAEL-- 1204
Cdd:TIGR00606  764 KNDIEEQETLLGTIMPEEESAKVCLTDVTIMERFQMEL-KDVERKIAQQAAKLQGSDL--DRTVQQVNQEKQEKQHELdt 840
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1205 -GEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKicrtLEDQLSEargKNEEIQRSLSELTTQKSRLQT 1283
Cdd:TIGR00606  841 vVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQ----FEEQLVE---LSTEVQSLIREIKDAKEQDSP 913
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1284 EAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSrhdCDLLREQYEEEQEGKA----ELQ 1359
Cdd:TIGR00606  914 LETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDG---KDDYLKQKETELNTVNaqleECE 990
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1360 RALSKANSEVAQWRTKYETDAIQ------------RTEELEEAKKKLAQRLQDSEEQveavnaKCASLEKTKQRLQGEVE 1427
Cdd:TIGR00606  991 KHQEKINEDMRLMRQDIDTQKIQerwlqdnltlrkRENELKEVEEELKQHLKEMGQM------QVLQMKQEHQKLEENID 1064
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462555497 1428 DLMVDVERANSLAAALDKKQRNFDKVLAEWKTK-CEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKN 1505
Cdd:TIGR00606 1065 LIKRNHVLALGRQKGYEKEIKHFKKELREPQFRdAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEIN 1143
PRK01156 PRK01156
chromosome segregation protein; Provisional
845-1331 1.09e-07

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 57.22  E-value: 1.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  845 ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQlqvQAESENLLDAEERCDQLIKAKFQLEAKIK--- 921
Cdd:PRK01156   239 SALNELSSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHM---KIINDPVYKNRNYINDYFKYKNDIENKKQils 315
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  922 ----------EVTERAEDEEEINAELTAKKRKLED---ECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDE 988
Cdd:PRK01156   316 nidaeinkyhAIIKKLSVLQKDYNDYIKKKSRYDDlnnQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISE 395
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  989 TIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSL------------------EQEKKLRVDLE 1050
Cdd:PRK01156   396 ILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMemlngqsvcpvcgttlgeEKSNHIINHYN 475
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1051 RNKRKLEGDLKLAQESILDLENDKQQL---DERLKKKDF-EYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEeieae 1126
Cdd:PRK01156   476 EKKSRLEEKIREIEIEVKDIDEKIVDLkkrKEYLESEEInKSINEYNKIESARADLEDIKIKINELKDKHDKYEE----- 550
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1127 ratrAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATlqheamvatlrkkhadsvaelGE 1206
Cdd:PRK01156   551 ----IKNRYKSLKLEDLDSKRTSWLNALAVISLIDIETNRSRSNEIKKQLNDLESRL---------------------QE 605
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1207 QIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKnEEIQRSLSELTTQKSRLQTEAG 1286
Cdd:PRK01156   606 IEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEI-DSIIPDLKEITSRINDIEDNLK 684
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462555497 1287 ELSRQLE-------EKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALA 1331
Cdd:PRK01156   685 KSRKALDdakanraRLESTIEILRTRINELSDRINDINETLESMKKIKKAIG 736
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
841-1078 1.34e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 56.56  E-value: 1.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  841 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLvqeknDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKI 920
Cdd:COG3206    168 LRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGLV-----DLSEEAKLLLQQLSELESQLAEARAELAEAEARL 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  921 KEVTERAEDEEEINAELTAkkrklEDECSELKKDIDDLELTLAkvEKEKHATEN--KVKNLTEELSGLdetiakltreKK 998
Cdd:COG3206    243 AALRAQLGSGPDALPELLQ-----SPVIQQLRAQLAELEAELA--ELSARYTPNhpDVIALRAQIAAL----------RA 305
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  999 ALQEAHQQALDDLQAEedkVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERnkrkLEGDLKLAQESILDLENDKQQLD 1078
Cdd:COG3206    306 QLQQEAQRILASLEAE---LEALQAREASLQAQLAQLEARLAELPELEAELRR----LEREVEVARELYESLLQRLEEAR 378
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1263-1873 2.08e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 56.18  E-value: 2.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1263 KNEEIQRSLSELTTQKSRL---QTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRH 1339
Cdd:TIGR04523   31 QDTEEKQLEKKLKTIKNELknkEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINS 110
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1340 DCDLLREQYEEEQEGKAELQRALSKANsevaqwrtKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTK 1419
Cdd:TIGR04523  111 EIKNDKEQKNKLEVELNKLEKQKKENK--------KNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEK 182
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1420 QRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWkTKCEESQAELEASLKEsrsLSTELFKLKNAYEEALDQLETV 1499
Cdd:TIGR04523  183 LNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLESQI-SELKKQNNQLKDNIEK---KQQEINEKTTEISNTQTQLNQL 258
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1500 KRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKilRIQLELTQVKSEID---RK 1576
Cdd:TIGR04523  259 KDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELKSELK--NQEKKLEEIQNQISqnnKI 336
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1577 IAEKDEEIEQLKRNYQrTVETMQSALDAEVRSRNEAIR-LKKKMEGDLNEI---EIQLSHANRQAAETLKHLRSVQGQLK 1652
Cdd:TIGR04523  337 ISQLNEQISQLKKELT-NSESENSEKQRELEEKQNEIEkLKKENQSYKQEIknlESQINDLESKIQNQEKLNQQKDEQIK 415
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1653 DTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELldsnervQLLHTQNTSLIHTKKKLE 1732
Cdd:TIGR04523  416 KLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQL-------KVLSRSINKIKQNLEQKQ 488
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1733 TDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKeqdtsahLERMKKNLEQTVKDLQHRLDEAEQ-LALKGGKK 1811
Cdd:TIGR04523  489 KELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEK-------LESEKKEKESKISDLEDELNKDDFeLKKENLEK 561
                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462555497 1812 QIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQ 1873
Cdd:TIGR04523  562 EIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAK 623
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
1256-1851 2.32e-07

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 55.91  E-value: 2.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1256 QLSEARGKNEEIqRSLSELT-TQKSRLQTEAGELS-----------------------------------RQLEEKESI- 1298
Cdd:pfam07111   71 QLQELRRLEEEV-RLLRETSlQQKMRLEAQAMELDalavaekagqaeaeglraalagaemvrknleegsqRELEEIQRLh 149
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1299 VSQLSRSKQAFTQQTEELKRQLEEENKAKNAL-------AHALQSSRHDCDLLREQY---EEEQEGKAELQRALSKANSE 1368
Cdd:pfam07111  150 QEQLSSLTQAHEEALSSLTSKAEGLEKSLNSLetkrageAKQLAEAQKEAELLRKQLsktQEELEAQVTLVESLRKYVGE 229
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1369 VAQWRTKYETDAIQRtEELEEAKKKLAQRLQDSEEQVEAVNAKCASLektKQRLQGEVEDLMVDVERANSLAAALDKKQR 1448
Cdd:pfam07111  230 QVPPEVHSQTWELER-QELLDTMQHLQEDRADLQATVELLQVRVQSL---THMLALQEEELTRKIQPSDSLEPEFPKKCR 305
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1449 NfdkVLAEWKTKCEESQAELEASLKESRSlstelfklknayeealdqletvkrENKNLEQEIADLTEQIAENGKtihele 1528
Cdd:pfam07111  306 S---LLNRWREKVFALMVQLKAQDLEHRD------------------------SVKQLRGQVAELQEQVTSQSQ------ 352
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1529 ksrkqielEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRnYQRTVETMQSALDAEVRS 1608
Cdd:pfam07111  353 --------EQAILQRALQDKAAEVEVERMSAKGLQMELSRAQEARRRQQQQTASAEEQLKF-VVNAMSSTQIWLETTMTR 423
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1609 RNEAIrlkkkmeGDLNEIEIQLSHANRQaAETLKHLRSVQGQLKDTQLHL----DDALRGQEDLKEQLAIVERRANLLQA 1684
Cdd:pfam07111  424 VEQAV-------ARIPSLSNRLSYAVRK-VHTIKGLMARKVALAQLRQEScpppPPAPPVDADLSLELEQLREERNRLDA 495
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1685 EVeELRATLEQTE--RARKLAEQELLDSNERVQllhtqntslihtkkKLETDLMQLQSEVEDASRDARNAEEKAKKAITD 1762
Cdd:pfam07111  496 EL-QLSAHLIQQEvgRAREQGEAERQQLSEVAQ--------------QLEQELQRAQESLASVGQQLEVARQGQQESTEE 560
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1763 AAMMAEELKKEQDTSAH-----LERMKKNLEQTVKDLQHRLDEA--EQLALKGGKKQIQKLETRIRELEFELEGEQKKNT 1835
Cdd:pfam07111  561 AASLRQELTQQQEIYGQalqekVAEVETRLREQLSDTKRRLNEArrEQAKAVVSLRQIQHRATQEKERNQELRRLQDEAR 640
                          650
                   ....*....|....*.
gi 2462555497 1836 ESVKglRKYERRVKEL 1851
Cdd:pfam07111  641 KEEG--QRLARRVQEL 654
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1350-1910 2.40e-07

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 55.88  E-value: 2.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1350 EEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK---------------------KLAQRLQDSEEQVEAV 1408
Cdd:pfam05483   71 ENSEGLSRLYSKLYKEAEKIKKWKVSIEAELKQKENKLQENRKiieaqrkaiqelqfenekvslKLEEEIQENKDLIKEN 150
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1409 NAK---CASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEaslkesrslstelFKL 1485
Cdd:pfam05483  151 NATrhlCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEELRVQAENARLEMH-------------FKL 217
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1486 KNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHE----LEKSRKQIEL--EKADIQLALEEAEAALEHEEAKI 1559
Cdd:pfam05483  218 KEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDltflLEESRDKANQleEKTKLQDENLKELIEKKDHLTKE 297
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1560 LR-IQLEL-----TQVKSEIDRKIAEK-------DEEIEQLKRNYQRTVETM-QSALDAEVRSRNEAIRLKK----KMEG 1621
Cdd:pfam05483  298 LEdIKMSLqrsmsTQKALEEDLQIATKticqlteEKEAQMEELNKAKAAHSFvVTEFEATTCSLEELLRTEQqrleKNED 377
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1622 DLNEIEIQLSHANRQAAETLKHLRSVQGQLKDtqlhLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERark 1701
Cdd:pfam05483  378 QLKIITMELQKKSSELEEMTKFKNNKEVELEE----LKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQAREK--- 450
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1702 laeqELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQD----TS 1777
Cdd:pfam05483  451 ----EIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEdiinCK 526
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1778 AHLERMKKNLEQTVKDLQHRLDEAEQLAlkggkkqiQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEE 1857
Cdd:pfam05483  527 KQEERMLKQIENLEEKEMNLRDELESVR--------EEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNN 598
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462555497 1858 DRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEER 1910
Cdd:pfam05483  599 LKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQK 651
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
840-1113 2.69e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 55.89  E-value: 2.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  840 LLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLqlqVQAESENLL---DAEERCDQLikakfql 916
Cdd:pfam15921  589 QVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKL---VNAGSERLRavkDIKQERDQL------- 658
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  917 eakIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNlteeLSGLDETIAKLTRE 996
Cdd:pfam15921  659 ---LNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKS----MEGSDGHAMKVAMG 731
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  997 KKALQEAHQQALDDLQAE----EDKVNSLNKTKSKLEQQVEDLESSLEQekklrVDLERNkrKLEGDLKLAQESILDLEN 1072
Cdd:pfam15921  732 MQKQITAKRGQIDALQSKiqflEEAMTNANKEKHFLKEEKNKLSQELST-----VATEKN--KMAGELEVLRSQERRLKE 804
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*
gi 2462555497 1073 DKQQLDERLKKKDFEY--CQ--LQSKVEDEQTLGLQFQKKIKELQ 1113
Cdd:pfam15921  805 KVANMEVALDKASLQFaeCQdiIQRQEQESVRLKLQHTLDVKELQ 849
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
847-1760 3.11e-07

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 55.82  E-value: 3.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQlqvqaesenllDAEERCDQLIKAKFQLEAKIKEVTER 926
Cdd:TIGR00606  230 EAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIK-----------ALKSRKKQMEKDNSELELKMEKVFQG 298
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  927 AEDE-EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIakLTREKKALQEAHQ 1005
Cdd:TIGR00606  299 TDEQlNDLYHNHQRTVREKERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHI--RARDSLIQSLATR 376
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1006 QALDDLQAEEDkvnSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRklegdlkLAQESILDLENDKQQLDERLKKKd 1085
Cdd:TIGR00606  377 LELDGFERGPF---SERQIKNFHTLVIERQEDEAKTAAQLCADLQSKER-------LKQEQADEIRDEKKGLGRTIELK- 445
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1086 feycqlQSKVEDEQTlglQFQKKIKELQARIEELEEEIEAERATRaKTEKQRSdYARELEELSERLEEAGGVTSTQIELN 1165
Cdd:TIGR00606  446 ------KEILEKKQE---ELKFVIKELQQLEGSSDRILELDQELR-KAERELS-KAEKNSLTETLKKEVKSLQNEKADLD 514
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1166 KKREAEflklrrDLEEATLQHEAMVATlrkkhadsvaelgeQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKAN 1245
Cdd:TIGR00606  515 RKLRKL------DQEMEQLNHHTTTRT--------------QMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQ 574
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1246 LEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSrSKQAFTQQTEELKRQLEEENK 1325
Cdd:TIGR00606  575 LEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVC-GSQDEESDLERLKEEIEKSSK 653
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1326 AKNALAHALQssrhdcdlLREQYEEEQEGKaelqralSKANSEVAQwrtkyetDAIQRTEELEEAKKKLAQRLQDSEEQV 1405
Cdd:TIGR00606  654 QRAMLAGATA--------VYSQFITQLTDE-------NQSCCPVCQ-------RVFQTEAELQEFISDLQSKLRLAPDKL 711
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1406 EAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELE---ASLKESRSLSTEL 1482
Cdd:TIGR00606  712 KSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGtimPEEESAKVCLTDV 791
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1483 FKLKNAYEEaldqletVKRENKNLEQEIADLteQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRI 1562
Cdd:TIGR00606  792 TIMERFQME-------LKDVERKIAQQAAKL--QGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHL 862
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1563 QLELTQVKSEiDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLK 1642
Cdd:TIGR00606  863 KSKTNELKSE-KLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQD 941
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1643 HLRSVQGQLKDTQLHLDDALRGQEDLKE-QLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQN 1721
Cdd:TIGR00606  942 KVNDIKEKVKNIHGYMKDIENKIQDGKDdYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNL 1021
                          890       900       910       920
                   ....*....|....*....|....*....|....*....|..
gi 2462555497 1722 TSLIHTK--KKLETDLMQLQSEV-EDASRDARNAEEKAKKAI 1760
Cdd:TIGR00606 1022 TLRKRENelKEVEEELKQHLKEMgQMQVLQMKQEHQKLEENI 1063
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1346-1583 3.20e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.77  E-value: 3.20e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1346 EQYEEEQEGKAELQRALSKANSEVAQWRTKyETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGE 1425
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKE-EKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1426 VEDLMVDVerANSLAAALDKKQRNFDKVLAEwktkcEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKREnkn 1505
Cdd:COG4942     99 LEAQKEEL--AELLRALYRLGRQPPLALLLS-----PEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAE--- 168
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462555497 1506 LEQEIADLTEQIAENGKTIHELEKSRKqielEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEE 1583
Cdd:COG4942    169 LEAERAELEALLAELEEERAALEALKA----ERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1581-1913 3.56e-07

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 55.41  E-value: 3.56e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1581 DEEIEQLK--RNYQRTVETMQ--SALDAEVRSRNEAI-RLKKKME----GDLNEIEIQLSHANRQ-AAETLKHLrsvqgq 1650
Cdd:COG3206     84 ETQIEILKsrPVLERVVDKLNldEDPLGEEASREAAIeRLRKNLTvepvKGSNVIEISYTSPDPElAAAVANAL------ 157
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1651 lkdTQLHLDdalrgqEDLKEQLAIVERRANLLQAEVEELRATLEQTERARK--LAEQELLDSNERVQLLHTQNTSlihtk 1728
Cdd:COG3206    158 ---AEAYLE------QNLELRREEARKALEFLEEQLPELRKELEEAEAALEefRQKNGLVDLSEEAKLLLQQLSE----- 223
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1729 kkLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEelkkeqdtSAHLERMKKNLEQTVKDLQhrldeaeQLALKG 1808
Cdd:COG3206    224 --LESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQ--------SPVIQQLRAQLAELEAELA-------ELSARY 286
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1809 GKK--QIQKLETRIRELEFELEGEQKKNTESVKG-LRKYERRVKELTYQSEEDRKNVLRLQdlvdKLQVKVKSYKRQAEE 1885
Cdd:COG3206    287 TPNhpDVIALRAQIAALRAQLQQEAQRILASLEAeLEALQAREASLQAQLAQLEARLAELP----ELEAELRRLEREVEV 362
                          330       340
                   ....*....|....*....|....*...
gi 2462555497 1886 ADEQANAHLTKFRKAQheLEEAEERADI 1913
Cdd:COG3206    363 ARELYESLLQRLEEAR--LAEALTVGNV 388
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1661-1891 3.62e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.77  E-value: 3.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1661 ALRGQEDLKEQLaivERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQS 1740
Cdd:COG4942     14 AAAAQADAAAEA---EAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEK 90
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1741 EVEDASRDARNAEEKAKKAITDAAMMAE----ELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE--AEQLALKGGKKQIQ 1814
Cdd:COG4942     91 EIAELRAELEAQKEELAELLRALYRLGRqpplALLLSPEDFLDAVRRLQYLKYLAPARREQAEElrADLAELAALRAELE 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1815 KLETRIRELEFELEGEQKK----NTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQA 1890
Cdd:COG4942    171 AERAELEALLAELEEERAAlealKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAA 250

                   .
gi 2462555497 1891 N 1891
Cdd:COG4942    251 L 251
PRK01156 PRK01156
chromosome segregation protein; Provisional
1005-1701 3.74e-07

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 55.29  E-value: 3.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1005 QQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAqesildlENDKQQLDERLKKk 1084
Cdd:PRK01156   172 KDVIDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNA-------MDDYNNLKSALNE- 243
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1085 dfeycqlQSKVEDEQTlglQFQKKIKELQARIEELEEEIEAERATRAKTEKqrsdyareleelserleeaggVTSTQIEL 1164
Cdd:PRK01156   244 -------LSSLEDMKN---RYESEIKTAESDLSMELEKNNYYKELEERHMK---------------------IINDPVYK 292
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1165 NKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKleKEKSEFKLEIDDLSSSMESVSKSKA 1244
Cdd:PRK01156   293 NRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLSVLQKDYNDYIKKK--SRYDDLNNQILELEGYEMDYNSYLK 370
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1245 NLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEeen 1324
Cdd:PRK01156   371 SIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNME--- 447
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1325 kaknalahaLQSSRHDCDLLReqyeeeqegkaelqralskansevaqwrTKYETDAIQR-TEELEEAKKKLAQRLQDSEE 1403
Cdd:PRK01156   448 ---------MLNGQSVCPVCG----------------------------TTLGEEKSNHiINHYNEKKSRLEEKIREIEI 490
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1404 QVEAVNAKCASLEKTKQRLQG-EVEDLMVDVERANSLAAALdKKQRNFDKVLAEWKTKCEESQAELeaslkesRSLSTEL 1482
Cdd:PRK01156   491 EVKDIDEKIVDLKKRKEYLESeEINKSINEYNKIESARADL-EDIKIKINELKDKHDKYEEIKNRY-------KSLKLED 562
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1483 FKLKN-AYEEALDQLETVkrenknleqEIADLTEQIAENGKTIHELEKSRKQIELEKADIqlaleeaeaaleheeakilr 1561
Cdd:PRK01156   563 LDSKRtSWLNALAVISLI---------DIETNRSRSNEIKKQLNDLESRLQEIEIGFPDD-------------------- 613
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1562 iqleltqvKSEIDRKIAEKDEEIEQL--KRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANrqaaE 1639
Cdd:PRK01156   614 --------KSYIDKSIREIENEANNLnnKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIE----D 681
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462555497 1640 TLKHLRSvqgqlkdtqlHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARK 1701
Cdd:PRK01156   682 NLKKSRK----------ALDDAKANRARLESTIEILRTRINELSDRINDINETLESMKKIKK 733
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
888-1425 4.76e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 54.77  E-value: 4.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  888 LQLQVQAESENLLDAEERCDQLIKAKFQ-LEAKIKEvterAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 966
Cdd:COG4717     47 LLERLEKEADELFKPQGRKPELNLKELKeLEEELKE----AEEKEEEYAELQEELEELEEELEELEAELEELREELEKLE 122
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  967 KEK--HATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQalddlqaeedkvnslnktKSKLEQQVEDLESSLEQEkk 1044
Cdd:COG4717    123 KLLqlLPLYQELEALEAELAELPERLEELEERLEELRELEEE------------------LEELEAELAELQEELEEL-- 182
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1045 lrvdLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKdfeycqlqskvedeqtlglqfQKKIKELQARIEeleeeie 1124
Cdd:COG4717    183 ----LEQLSLATEEELQDLAEELEELQQRLAELEEELEEA---------------------QEELEELEEELE------- 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1125 aeratRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELnkkreAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAEL 1204
Cdd:COG4717    231 -----QLENELEAAALEERLKEARLLLLIAAALLALLGLG-----GSLLSLILTIAGVLFLVLGLLALLFLLLAREKASL 300
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1205 GEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQrsLSELTTQKSRLQTE 1284
Cdd:COG4717    301 GKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQ--LEELEQEIAALLAE 378
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1285 AGelSRQLEEKESIVSQLSRsKQAFTQQTEELKRQLEEENKAKNALAHAlqssrHDCDLLREQYEEEQEGKAELQRALSK 1364
Cdd:COG4717    379 AG--VEDEEELRAALEQAEE-YQELKEELEELEEQLEELLGELEELLEA-----LDEEELEEELEELEEELEELEEELEE 450
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462555497 1365 ANSEVAqwRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCAS---LEKTKQRLQGE 1425
Cdd:COG4717    451 LREELA--ELEAELEQLEEDGELAELLQELEELKAELRELAEEWAALKLAlelLEEAREEYREE 512
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
1504-1927 4.90e-07

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 54.83  E-value: 4.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1504 KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEH-EEAKILRIQLELTQVK-SEIDRKIAEKD 1581
Cdd:pfam10174  174 KKSGEEDWERTRRIAEAEMQLGHLEVLLDQKEKENIHLREELHRRNQLQPDpAKTKALQTVIEMKDTKiSSLERNIRDLE 253
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1582 EEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKME---GDLNEIEIQLshanrQAAETlkHLRSVQGQLKDTQLHL 1658
Cdd:pfam10174  254 DEVQMLKTNGLLHTEDREEEIKQMEVYKSHSKFMKNKIDqlkQELSKKESEL-----LALQT--KLETLTNQNSDCKQHI 326
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1659 ddalrgqEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQllhTQNTSLIHTKKKL---ETDL 1735
Cdd:pfam10174  327 -------EVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKS---TLAGEIRDLKDMLdvkERKI 396
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1736 MQLQSEVEDASRDARNAE-------EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL-EQTVKDLQHRLDEAEQL--A 1805
Cdd:pfam10174  397 NVLQKKIENLQEQLRDKDkqlaglkERVKSLQTDSSNTDTALTTLEEALSEKERIIERLkEQREREDRERLEELESLkkE 476
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1806 LKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDlvdklqvkvKSYKRQAEE 1885
Cdd:pfam10174  477 NKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLEN---------QLKKAHNAE 547
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 2462555497 1886 ADEQANAHLT-KFRKAQHELEEAEERADIAESQVNKLRAKTRD 1927
Cdd:pfam10174  548 EAVRTNPEINdRIRLLEQEVARYKEESGKAQAEVERLLGILRE 590
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1470-1717 4.96e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.38  E-value: 4.96e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1470 ASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKAdiqlaleeae 1549
Cdd:COG4942     17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELA---------- 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1550 aaleheeakilriqlELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEgdlneieiQ 1629
Cdd:COG4942     87 ---------------ELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLK--------Y 143
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1630 LSHANRQAAETlkhLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLD 1709
Cdd:COG4942    144 LAPARREQAEE---LRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQ 220

                   ....*...
gi 2462555497 1710 SNERVQLL 1717
Cdd:COG4942    221 EAEELEAL 228
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1460-1883 6.31e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 54.39  E-value: 6.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1460 KCEESQAELEASLKESRSLSTELFKLKNAYEeALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKA 1539
Cdd:COG4717     99 ELEEELEELEAELEELREELEKLEKLLQLLP-LYQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQE 177
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1540 DIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLkkkM 1619
Cdd:COG4717    178 ELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLL---I 254
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1620 EGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERA 1699
Cdd:COG4717    255 AAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDL 334
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1700 RKLAEQELLDSNERVQLLHTQNTSLIH--TKKKLETDLMQLQSEVEDASRDArnAEEKAKKAITDAAMMAEELKKEQDTS 1777
Cdd:COG4717    335 SPEELLELLDRIEELQELLREAEELEEelQLEELEQEIAALLAEAGVEDEEE--LRAALEQAEEYQELKEELEELEEQLE 412
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1778 AHLERMKKNLEQTVKD-LQHRLDEAEQlALKGGKKQIQKLETRIRELEFELEgEQKKNTESVKGLRKYERRVKELTYQSE 1856
Cdd:COG4717    413 ELLGELEELLEALDEEeLEEELEELEE-ELEELEEELEELREELAELEAELE-QLEEDGELAELLQELEELKAELRELAE 490
                          410       420
                   ....*....|....*....|....*..
gi 2462555497 1857 EDRKNVLrLQDLVDKLQVKVKSYKRQA 1883
Cdd:COG4717    491 EWAALKL-ALELLEEAREEYREERLPP 516
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1502-1725 7.88e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 53.61  E-value: 7.88e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1502 ENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEID---RKIA 1578
Cdd:COG4942     21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAelrAELE 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1579 EKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEgdlneieiQLSHANRQAAETLkhlRSVQGQLKDTQLHL 1658
Cdd:COG4942    101 AQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLK--------YLAPARREQAEEL---RADLAELAALRAEL 169
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462555497 1659 DDAlrgQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLI 1725
Cdd:COG4942    170 EAE---RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLE 233
Motor_domain cd01363
Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the ...
652-676 8.96e-07

Myosin and Kinesin motor domain; Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes. Some of the names do not match with what is given in the sequence list. This is because they are based on the current nomenclature by Kollmar/Sebe-Pedros.


Pssm-ID: 276814 [Multi-domain]  Cd Length: 170  Bit Score: 50.81  E-value: 8.96e-07
                           10        20
                   ....*....|....*....|....*
gi 2462555497  652 FRENLNKLMSNLRTTHPHFVRCIIP 676
Cdd:cd01363    146 INESLNTLMNVLRATRPHFVRCISP 170
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1675-1919 9.19e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 54.15  E-value: 9.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1675 VERRANLLQAEVEELRATLEQTERARKlaEQELLdsnERVQLLHTQntslihtKKKLETDLMQLqseveDASRDARNAEE 1754
Cdd:COG4913    223 TFEAADALVEHFDDLERAHEALEDARE--QIELL---EPIRELAER-------YAAARERLAEL-----EYLRAALRLWF 285
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1755 KAKKAitdaAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKn 1834
Cdd:COG4913    286 AQRRL----ELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLERELEERERR- 360
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1835 tesvkgLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLqvkVKSYKRQAEEADEQANAHLTKFRKAQHELEEAE-ERADI 1913
Cdd:COG4913    361 ------RARLEALLAALGLPLPASAEEFAALRAEAAAL---LEALEEELEALEEALAEAEAALRDLRRELRELEaEIASL 431

                   ....*.
gi 2462555497 1914 AESQVN 1919
Cdd:COG4913    432 ERRKSN 437
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
1039-1322 1.02e-06

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 53.70  E-value: 1.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1039 LEQE-KKLRVDLERNkRKLEGDLKLAQESILDLE----NDKQQLderlkKKDFEYCQ------LQSKVEDEQTLGlQFQK 1107
Cdd:pfam09726  400 LEQDiKKLKAELQAS-RQTEQELRSQISSLTSLErslkSELGQL-----RQENDLLQtklhnaVSAKQKDKQTVQ-QLEK 472
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1108 KIKELQArieeleeeieaeraTRAKTEKQrsdyareleelserleeaggvtstqieLNKKREaeflklRRDLEEATLQHE 1187
Cdd:pfam09726  473 RLKAEQE--------------ARASAEKQ---------------------------LAEEKK------RKKEEEATAARA 505
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1188 AmvatlrkkhADSVAELGEQIDNLQRVKQKLEKE----KSEFKL---EIDDLSSSMESVSKSKANlEKICRTLEDQLSEA 1260
Cdd:pfam09726  506 V---------ALAAASRGECTESLKQRKRELESEikklTHDIKLkeeQIRELEIKVQELRKYKES-EKDTEVLMSALSAM 575
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462555497 1261 RGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEekesIVSQLSRSKQaftQQTEELKRQLEE 1322
Cdd:pfam09726  576 QDKNQHLENSLSAETRIKLDLFSALGDAKRQLE----IAQGQIYQKD---QEIKDLKQKIAE 630
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
842-1034 1.34e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 52.91  E-value: 1.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  842 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQ------ 915
Cdd:COG3883     24 ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYRsggsvs 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  916 -----LEAK-IKEVTERA-------EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 982
Cdd:COG3883    104 yldvlLGSEsFSDFLDRLsalskiaDADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEAL 183
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462555497  983 LSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVED 1034
Cdd:COG3883    184 LAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAA 235
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1243-1492 1.57e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.46  E-value: 1.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1243 KANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE 1322
Cdd:COG4942     22 AAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEA 101
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1323 EnkaKNALAhalqssrhdcDLLREQYEEEQEGKAELqrALSKANSEVAQWRTKYetdaiqrteeleeakkkLAQRLQDSE 1402
Cdd:COG4942    102 Q---KEELA----------ELLRALYRLGRQPPLAL--LLSPEDFLDAVRRLQY-----------------LKYLAPARR 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1403 EQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTEL 1482
Cdd:COG4942    150 EQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALI 229
                          250
                   ....*....|
gi 2462555497 1483 FKLKNAYEEA 1492
Cdd:COG4942    230 ARLEAEAAAA 239
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1620-1837 1.62e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 52.52  E-value: 1.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1620 EGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEqtERA 1699
Cdd:COG3883     15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELG--ERA 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1700 RKLAEQELLDSNERVQLLHTQNTSLIhtkkkletDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEqdtsah 1779
Cdd:COG3883     93 RALYRSGGSVSYLDVLLGSESFSDFL--------DRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAE------ 158
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462555497 1780 LERMKKNLEQTVKDLQHRLDEAEQLaLKGGKKQIQKLETRIRELEFELEGEQKKNTES 1837
Cdd:COG3883    159 LEALKAELEAAKAELEAQQAEQEAL-LAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
PRK01156 PRK01156
chromosome segregation protein; Provisional
884-1534 1.72e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 53.37  E-value: 1.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  884 EKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELtakkRKLEDECSELKKDIDDLELTLA 963
Cdd:PRK01156   139 EMDSLISGDPAQRKKILDEILEINSLERNYDKLKDVIDMLRAEISNIDYLEEKL----KSSNLELENIKKQIADDEKSHS 214
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  964 KVEKEKHATENKVKNLTEELSGLDETIAKLTR---EKKALQEAHQQALDDLQAEEDKVNSLnktkSKLEQQVEDLESSLE 1040
Cdd:PRK01156   215 ITLKEIERLSIEYNNAMDDYNNLKSALNELSSledMKNRYESEIKTAESDLSMELEKNNYY----KELEERHMKIINDPV 290
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1041 QEKKLRVdleRNKRKLEGDLKLAQESILDLENDKQQLDERLKkkdfeycqlqsKVEDEQTLGLQFQKKIKELQarieele 1120
Cdd:PRK01156   291 YKNRNYI---NDYFKYKNDIENKKQILSNIDAEINKYHAIIK-----------KLSVLQKDYNDYIKKKSRYD------- 349
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1121 eeieaeratraKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADs 1200
Cdd:PRK01156   350 -----------DLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEINVK- 417
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1201 VAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLsssmesvskskaNLEKICRTLEDQLSEargknEEIQRSLSELTTQKSR 1280
Cdd:PRK01156   418 LQDISSKVSSLNQRIRALRENLDELSRNMEML------------NGQSVCPVCGTTLGE-----EKSNHIINHYNEKKSR 480
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1281 LQTEAGELSRQLEEKESIVSQLSRSKQAFtqQTEELKRQLEEENKAKNAlAHALQSSRHDCDLLREQYEEEQEGKAELQR 1360
Cdd:PRK01156   481 LEEKIREIEIEVKDIDEKIVDLKKRKEYL--ESEEINKSINEYNKIESA-RADLEDIKIKINELKDKHDKYEEIKNRYKS 557
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1361 A-LSKANSEVAQW------RTKYETDAIQ-RTEELEEAKKKLAQRLQDSEEQVEAVNakcASLEKTKQRLQGEVEDLMVD 1432
Cdd:PRK01156   558 LkLEDLDSKRTSWlnalavISLIDIETNRsRSNEIKKQLNDLESRLQEIEIGFPDDK---SYIDKSIREIENEANNLNNK 634
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1433 VERANSLAAALDK---KQRNFDKVLAEWKTKcEESQAELEASLKESrslSTELFKLKNAYEEALDQLETVKRENKNLEQE 1509
Cdd:PRK01156   635 YNEIQENKILIEKlrgKIDNYKKQIAEIDSI-IPDLKEITSRINDI---EDNLKKSRKALDDAKANRARLESTIEILRTR 710
                          650       660
                   ....*....|....*....|....*
gi 2462555497 1510 IADLTEQIAENGKTIHELEKSRKQI 1534
Cdd:PRK01156   711 INELSDRINDINETLESMKKIKKAI 735
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
1304-1910 1.72e-06

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 53.22  E-value: 1.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1304 RSKQAFTQQTEELKRQLEEenkaknalahaLQSSRHDCDLLREQyEEEQEGKAELQralskansevaqwrtKYETDAIQR 1383
Cdd:pfam07111   56 EGSQALSQQAELISRQLQE-----------LRRLEEEVRLLRET-SLQQKMRLEAQ---------------AMELDALAV 108
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1384 TEELEEAKkklAQRLQDSEEQVEAVNakcASLEKTKQRLQGEVEDL----MVDVERANSLA-AALDKKQRNFDKVLAEWK 1458
Cdd:pfam07111  109 AEKAGQAE---AEGLRAALAGAEMVR---KNLEEGSQRELEEIQRLhqeqLSSLTQAHEEAlSSLTSKAEGLEKSLNSLE 182
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1459 TKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKnlEQEIADLTEQIAENGKtiHELEKSRKQIELEK 1538
Cdd:pfam07111  183 TKRAGEAKQLAEAQKEAELLRKQLSKTQEELEAQVTLVESLRKYVG--EQVPPEVHSQTWELER--QELLDTMQHLQEDR 258
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1539 ADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIrlkKK 1618
Cdd:pfam07111  259 ADLQATVELLQVRVQSLTHMLALQEEELTRKIQPSDSLEPEFPKKCRSLLNRWREKVFALMVQLKAQDLEHRDSV---KQ 335
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1619 MEGDLNEIEIQLSHANRQAAETLKHLRSVQGQL-------KDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRA 1691
Cdd:pfam07111  336 LRGQVAELQEQVTSQSQEQAILQRALQDKAAEVevermsaKGLQMELSRAQEARRRQQQQTASAEEQLKFVVNAMSSTQI 415
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1692 TLEQTerarklaeqeLLDSNERVQLLHTQNTSLIHTKKKLET--DLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEE 1769
Cdd:pfam07111  416 WLETT----------MTRVEQAVARIPSLSNRLSYAVRKVHTikGLMARKVALAQLRQESCPPPPPAPPVDADLSLELEQ 485
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1770 LKKEQDT-SAHLERMKKNLEQTVKDLQHRlDEAEQLALKGGKKQIQKLETRIRE--------LEFELEGEQkKNTESVKG 1840
Cdd:pfam07111  486 LREERNRlDAELQLSAHLIQQEVGRAREQ-GEAERQQLSEVAQQLEQELQRAQEslasvgqqLEVARQGQQ-ESTEEAAS 563
                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1841 LRKYERRVKELTYQSEEDrknvlRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEER 1910
Cdd:pfam07111  564 LRQELTQQQEIYGQALQE-----KVAEVETRLREQLSDTKRRLNEARREQAKAVVSLRQIQHRATQEKER 628
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
912-1099 2.22e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 52.14  E-value: 2.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  912 AKFQLEAKIKEVTERAEDEEEINAELtakkRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIA 991
Cdd:COG3883     14 ADPQIQAKQKELSELQAELEAAQAEL----DALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELG 89
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  992 KLTRekkALQEA---------------------HQQALDDL-QAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDL 1049
Cdd:COG3883     90 ERAR---ALYRSggsvsyldvllgsesfsdfldRLSALSKIaDADADLLEELKADKAELEAKKAELEAKLAELEALKAEL 166
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1050 ERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQ 1099
Cdd:COG3883    167 EAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAA 216
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1747-1933 2.93e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 52.63  E-value: 2.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1747 RDARNAEE----KAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEqlalkggkKQIQKLETRIRE 1822
Cdd:COG1196    207 RQAEKAERyrelKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELE--------AELEELRLELEE 278
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1823 LEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQH 1902
Cdd:COG1196    279 LELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEA 358
                          170       180       190
                   ....*....|....*....|....*....|.
gi 2462555497 1903 ELEEAEERADIAESQVNKLRAKTRDFTSSRM 1933
Cdd:COG1196    359 ELAEAEEALLEAEAELAEAEEELEELAEELL 389
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
1190-1535 3.05e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 52.65  E-value: 3.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1190 VATLRKKHADSVAELGEQIDNLQRVKQKL-EKEKSEFKLEIDDLSSSMESVSKSKA--NLEKICRTLEDqLSEARGKNEE 1266
Cdd:COG3096    287 ALELRRELFGARRQLAEEQYRLVEMARELeELSARESDLEQDYQAASDHLNLVQTAlrQQEKIERYQED-LEELTERLEE 365
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1267 IQRSLSELTTQKSRLQTEAGELSrqlEEKESIVSQLSRSKQAF-TQQTEELKRQleeenKAKNALAHAlqssRHDCDLlr 1345
Cdd:COG3096    366 QEEVVEEAAEQLAEAEARLEAAE---EEVDSLKSQLADYQQALdVQQTRAIQYQ-----QAVQALEKA----RALCGL-- 431
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1346 eqyeeeqegkaelqRALSKANseVAQWRTKYETDAIQRTEELEEakkkLAQRLQDSEEQVEAVNAKCASLEKtkqrLQGE 1425
Cdd:COG3096    432 --------------PDLTPEN--AEDYLAAFRAKEQQATEEVLE----LEQKLSVADAARRQFEKAYELVCK----IAGE 487
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1426 VEDlmvdvERANSLAAALDKKQRNFdKVLAEWKTKCEESQAELE---ASLKESRSLSTELFKLKNAYEEALDQLETVKRE 1502
Cdd:COG3096    488 VER-----SQAWQTARELLRRYRSQ-QALAQRLQQLRAQLAELEqrlRQQQNAERLLEEFCQRIGQQLDAAEELEELLAE 561
                          330       340       350
                   ....*....|....*....|....*....|...
gi 2462555497 1503 nknLEQEIADLTEQIAENGKTIHELEKSRKQIE 1535
Cdd:COG3096    562 ---LEAQLEELEEQAAEAVEQRSELRQQLEQLR 591
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1382-1639 3.32e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 51.75  E-value: 3.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1382 QRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANslaAALDKKQRNFDKVLAewktkc 1461
Cdd:COG3883     23 KELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAE---AEIEERREELGERAR------ 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1462 eesqaeleaSLKESRSLSTELFKLKNA--YEEALDQLETVKRENKNLEQEIADLTEQIAEngktiheLEKSRKQIELEKA 1539
Cdd:COG3883     94 ---------ALYRSGGSVSYLDVLLGSesFSDFLDRLSALSKIADADADLLEELKADKAE-------LEAKKAELEAKLA 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1540 DIQLAleeaeaaleheeakilriQLELTQVKSEIDRKIAEKDEEIEQLKRNyQRTVETMQSALDAEVRSRNEAIRLKKKM 1619
Cdd:COG3883    158 ELEAL------------------KAELEAAKAELEAQQAEQEALLAQLSAE-EAAAEAQLAELEAELAAAEAAAAAAAAA 218
                          250       260
                   ....*....|....*....|
gi 2462555497 1620 EGDLNEIEIQLSHANRQAAE 1639
Cdd:COG3883    219 AAAAAAAAAAAAAAAAAAAA 238
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1307-1535 3.89e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.30  E-value: 3.89e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1307 QAFTQQTEELKRQLEEENKAKNALAHALQSsrhdcdlLREQYEEEQEGKAELQRALSKANSEVAqwrtKYETDAIQRTEE 1386
Cdd:COG4942     16 AAQADAAAEAEAELEQLQQEIAELEKELAA-------LKKEEKALLKQLAALERRIAALARRIR----ALEQELAALEAE 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1387 LEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQR-------LQGEVEDLMVDVERANSLAAALDKKQRNFDKV---LAE 1456
Cdd:COG4942     85 LAELEKEIAELRAELEAQKEELAELLRALYRLGRQpplalllSPEDFLDAVRRLQYLKYLAPARREQAEELRADlaeLAA 164
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462555497 1457 WKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLEtvkRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIE 1535
Cdd:COG4942    165 LRAELEAERAELEALLAELEEERAALEALKAERQKLLARLE---KELAELAAELAELQQEAEELEALIARLEAEAAAAA 240
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1357-1776 5.21e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 51.69  E-value: 5.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1357 ELQRALSKANSEVAQWRTKYET--DAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKC------ASLEKTKQRLQGEVED 1428
Cdd:COG4717     75 ELEEELKEAEEKEEEYAELQEEleELEEELEELEAELEELREELEKLEKLLQLLPLYQelealeAELAELPERLEELEER 154
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1429 LMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLE- 1507
Cdd:COG4717    155 LEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLEn 234
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1508 -QEIADLTEQIAENGK------TIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEK 1580
Cdd:COG4717    235 eLEAAALEERLKEARLllliaaALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALE 314
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1581 D---EEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAetlkhLRSVQGQLKDTQLH 1657
Cdd:COG4717    315 EleeEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAAL-----LAEAGVEDEEELRA 389
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1658 LDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLA--EQELLDSNERVQLLHTQNTSLIHTKKKLETD- 1734
Cdd:COG4717    390 ALEQAEEYQELKEELEELEEQLEELLGELEELLEALDEEELEEELEelEEELEELEEELEELREELAELEAELEQLEEDg 469
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|...
gi 2462555497 1735 -LMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT 1776
Cdd:COG4717    470 eLAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREE 512
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1465-1696 5.45e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 51.56  E-value: 5.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1465 QAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENK--NLEQEIADLTEQIAEngktiheLEKSRKQIELEKADIQ 1542
Cdd:COG3206    167 ELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQKNGlvDLSEEAKLLLQQLSE-------LESQLAEARAELAEAE 239
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1543 LALEEAEAALEHEEAKIlrIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQsALDAEVRSRNEaiRLKKKMEGD 1622
Cdd:COG3206    240 ARLAALRAQLGSGPDAL--PELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVI-ALRAQIAALRA--QLQQEAQRI 314
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462555497 1623 LNEIEIQLSHANRQAAEtlkhLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQT 1696
Cdd:COG3206    315 LASLEAELEALQAREAS----LQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQRLEEARLAEALT 384
PRK12704 PRK12704
phosphodiesterase; Provisional
1349-1522 6.17e-06

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 50.93  E-value: 6.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1349 EEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRlqdsEEQVEavnAKCASLEKTKQRLQGEVED 1428
Cdd:PRK12704    46 EAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQK----EENLD---RKLELLEKREEELEKKEKE 118
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1429 lmvdveranslaaaLDKKQRNFDKvlaeWKTKCEESQAELEASLKESRSLSTElfklkNAYEEALDQLEtvkrenKNLEQ 1508
Cdd:PRK12704   119 --------------LEQKQQELEK----KEEELEELIEEQLQELERISGLTAE-----EAKEILLEKVE------EEARH 169
                          170
                   ....*....|....
gi 2462555497 1509 EIADLTEQIAENGK 1522
Cdd:PRK12704   170 EAAVLIKEIEEEAK 183
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
855-1086 7.14e-06

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 51.31  E-value: 7.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  855 EEFQKTKDELAKSEAKR----KELEEKLVTLVQEKNDLQLQVQAESEnlldaeercdqlikaKFQLEAKIKEVTERAEDE 930
Cdd:pfam18971  610 DEVKKAQKDLEKSLRKRehleKEVEKKLESKSGNKNKMEAKAQANSQ---------------KDEIFALINKEANRDARA 674
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  931 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAkLTREKKALQEAHQQALDD 1010
Cdd:pfam18971  675 IAYTQNLKGIKRELSDKLEKISKDLKDFSKSFDEFKNGKNKDFSKAEETLKALKGSVKDLG-INPEWISKVENLNAALNE 753
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1011 LQaeedkvNSLNKTKSKLEQQVEDLESSLEQ--------EKKLRVDLERNKRKLEGDLKLAQESILDLEN-DKQQLDERL 1081
Cdd:pfam18971  754 FK------NGKNKDFSKVTQAKSDLENSVKDviinqkvtDKVDNLNQAVSVAKAMGDFSRVEQVLADLKNfSKEQLAQQA 827

                   ....*.
gi 2462555497 1082 KK-KDF 1086
Cdd:pfam18971  828 QKnEDF 833
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
1252-1738 7.21e-06

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 50.98  E-value: 7.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1252 TLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQ-------LSRSKQAFTQQTEELKRQLEEEN 1324
Cdd:pfam10174  314 TLTNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKktkqlqdLTEEKSTLAGEIRDLKDMLDVKE 393
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1325 KAKNALA---HALQSSRHDCDL----LREQYEEEQEGK-------AELQRALSKANSEVAQWRTKYETDAIQRTEELEEA 1390
Cdd:pfam10174  394 RKINVLQkkiENLQEQLRDKDKqlagLKERVKSLQTDSsntdtalTTLEEALSEKERIIERLKEQREREDRERLEELESL 473
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1391 KKKlaqrLQDSEEQVEAVNAKCASLEKTKQRLQgevedlmvdvERANSLAAALDKKQrnfdkvlaewkTKCEESQAELEA 1470
Cdd:pfam10174  474 KKE----NKDLKEKVSALQPELTEKESSLIDLK----------EHASSLASSGLKKD-----------SKLKSLEIAVEQ 528
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1471 SLKESRSLSTELFKLKNAYEEALDQLETVKREnKNLEQEIADLTEqiaengktihelEKSRKQIELEkadiqlaleeaea 1550
Cdd:pfam10174  529 KKEECSKLENQLKKAHNAEEAVRTNPEINDRI-RLLEQEVARYKE------------ESGKAQAEVE------------- 582
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1551 aleheeaKILRIQLELTQVKSEIDRKIAE---------KDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEG 1621
Cdd:pfam10174  583 -------RLLGILREVENEKNDKDKKIAElesltlrqmKEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQL 655
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1622 DLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLdDALRgQEDLKEQLAIVERRANLLQAEVEELRAT---LEQTER 1698
Cdd:pfam10174  656 QLEELMGALEKTRQELDATKARLSSTQQSLAEKDGHL-TNLR-AERRKQLEEILEMKQEALLAAISEKDANialLELSSS 733
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 2462555497 1699 ARKLAEQElldsnerVQLLHTQNTSLIHTKKKLETDLMQL 1738
Cdd:pfam10174  734 KKKKTQEE-------VMALKREKDRLVHQLKQQTQNRMKL 766
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1344-1629 7.57e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 50.89  E-value: 7.57e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1344 LREQYEE---EQEGKAELQRALSKANSEVAQWRTKY---ETDAIQRTEELEEAkkklaqRLQDSEEQVEAVNAKCASLEK 1417
Cdd:pfam17380  301 LRQEKEEkarEVERRRKLEEAEKARQAEMDRQAAIYaeqERMAMERERELERI------RQEERKRELERIRQEEIAMEI 374
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1418 TKQRlqgEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTElfKLKNAYEEALDQLE 1497
Cdd:pfam17380  375 SRMR---ELERLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQR--EVRRLEEERAREME 449
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1498 TVKRENKNLEQEIADLTEQIAENGKTIHELEKS---RKQIELEKADI---QLALEEAEAALEHEEAKILRIQLELTQ--V 1569
Cdd:pfam17380  450 RVRLEEQERQQQVERLRQQEEERKRKKLELEKEkrdRKRAEEQRRKIlekELEERKQAMIEEERKRKLLEKEMEERQkaI 529
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1570 KSEIDRKIAEKDEEIEQLKRNYQRTVETMQSAldAEVRSRNEAIRLKKKMEGDLNEIEIQ 1629
Cdd:pfam17380  530 YEEERRREAEEERRKQQEMEERRRIQEQMRKA--TEERSRLEAMEREREMMRQIVESEKA 587
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
862-1067 8.13e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 50.21  E-value: 8.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  862 DELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIkevteraedeEEINAELTAKK 941
Cdd:COG3883     16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEI----------AEAEAEIEERR 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  942 RKLEDECSELKK---DIDDLELTLAkvekekhatenkVKNLTEELSGLD--ETIAKLTREKKALQEAHQQALDDLQAE-E 1015
Cdd:COG3883     86 EELGERARALYRsggSVSYLDVLLG------------SESFSDFLDRLSalSKIADADADLLEELKADKAELEAKKAElE 153
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462555497 1016 DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESI 1067
Cdd:COG3883    154 AKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAEL 205
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1252-1418 8.18e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 49.15  E-value: 8.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1252 TLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAK--NA 1329
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKeyEA 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1330 LAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAqwrtkyetdaiQRTEELEEAKKKLAQRLQDSEEQVEAVN 1409
Cdd:COG1579     94 LQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELA-----------ELEAELEEKKAELDEELAELEAELEELE 162

                   ....*....
gi 2462555497 1410 AKCASLEKT 1418
Cdd:COG1579    163 AEREELAAK 171
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1059-1622 8.26e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 51.07  E-value: 8.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1059 DLKLAQESILDLENDKQQLdERLKKKDFEYCQLQSKVEDEQTLGLQF-----QKKIKELQARIEELEEEIEAERATRAKT 1133
Cdd:COG4913    236 DLERAHEALEDAREQIELL-EPIRELAERYAAARERLAELEYLRAALrlwfaQRRLELLEAELEELRAELARLEAELERL 314
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1134 EKQRSDYARELEELSERLEEAGGVTSTQIE-----LNKKRE------AEFLKLRRDLEEATLQHEAMVATLRKKHADSVA 1202
Cdd:COG4913    315 EARLDALREELDELEAQIRGNGGDRLEQLEreierLERELEererrrARLEALLAALGLPLPASAEEFAALRAEAAALLE 394
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1203 ELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELttqksrLQ 1282
Cdd:COG4913    395 ALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDALAEALGLDEAELPFVGEL------IE 468
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1283 TEAGELS--------------------RQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDC- 1341
Cdd:COG4913    469 VRPEEERwrgaiervlggfaltllvppEHYAAALRWVNRLHLRGRLVYERVRTGLPDPERPRLDPDSLAGKLDFKPHPFr 548
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1342 DLLREQYEEEQ-----EGKAELQRA--------LSKANSEVAQ------WRTKYET--DAIQRTEELEEAKKKLAQRLQD 1400
Cdd:COG4913    549 AWLEAELGRRFdyvcvDSPEELRRHpraitragQVKGNGTRHEkddrrrIRSRYVLgfDNRAKLAALEAELAELEEELAE 628
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1401 SEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERAnSLAAALDKKqrnfdkvlaewktkcEESQAELEASLKESRSLST 1480
Cdd:COG4913    629 AEERLEALEAELDALQERREALQRLAEYSWDEIDVA-SAEREIAEL---------------EAELERLDASSDDLAALEE 692
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1481 ELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEheeakil 1560
Cdd:COG4913    693 QLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGDAVER------- 765
                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462555497 1561 RIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGD 1622
Cdd:COG4913    766 ELRENLEERIDALRARLNRAEEELERAMRAFNREWPAETADLDADLESLPEYLALLDRLEED 827
Filament pfam00038
Intermediate filament protein;
854-1091 9.85e-06

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 49.53  E-value: 9.85e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  854 KEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEER--------CDQLIKAKFQLEAKIKEVTE 925
Cdd:pfam00038    3 KEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGAEPSRLYSLYEKeiedlrrqLDTLTVERARLQLELDNLRL 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  926 RAEDEEEINAELTAKKRKLEDECSELKKDIDdlELTLAKVEkekhaTENKVKNLTEELSGL----DETIAKLT------- 994
Cdd:pfam00038   83 AAEDFRQKYEDELNLRTSAENDLVGLRKDLD--EATLARVD-----LEAKIESLKEELAFLkknhEEEVRELQaqvsdtq 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  995 -----------------------------REKKALQEAHQQALDDLQAEEDKVN-SLNKTKSKLEQ---QVEDLESSLEQ 1041
Cdd:pfam00038  156 vnvemdaarkldltsalaeiraqyeeiaaKNREEAEEWYQSKLEELQQAAARNGdALRSAKEEITElrrTIQSLEIELQS 235
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462555497 1042 EKKLRVDLERNKRKLE----GDLKLAQESILDLENDKQQLDERLKKKDFEYCQL 1091
Cdd:pfam00038  236 LKKQKASLERQLAETEeryeLQLADYQELISELEAELQETRQEMARQLREYQEL 289
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1566-1940 1.06e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 50.83  E-value: 1.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1566 LTQVKSEIDRKIAEKDEEIEQlKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLshanrqaaETLKHLR 1645
Cdd:PRK03918   167 LGEVIKEIKRRIERLEKFIKR-TENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEV--------KELEELK 237
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1646 SVQGQLKDTQLHLDDALRGQEDLKEQLaivERRANLLQAEVEELRATLEQTERARKLAEQELldsnervqllhtqntSLI 1725
Cdd:PRK03918   238 EEIEELEKELESLEGSKRKLEEKIREL---EERIEELKKEIEELEEKVKELKELKEKAEEYI---------------KLS 299
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1726 HTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEqTVKDLQHRLDEAEQLA 1805
Cdd:PRK03918   300 EFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHE-LYEEAKAKKEELERLK 378
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1806 LKGGKKQIQKLETRIRELEfelegeqKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQdlvdKLQVKVKSYKRQAEE 1885
Cdd:PRK03918   379 KRLTGLTPEKLEKELEELE-------KAKEEIEEEISKITARIGELKKEIKELKKAIEELK----KAKGKCPVCGRELTE 447
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1886 AD-----EQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE 1940
Cdd:PRK03918   448 EHrkellEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKE 507
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
847-1070 1.06e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 50.51  E-value: 1.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  847 EKEMATMKEEFqktKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTER 926
Cdd:pfam05557   15 QNEKKQMELEH---KRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRLKKKYLEALNKK 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  927 AEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQ 1006
Cdd:pfam05557   92 LNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNLEKQQSSLAEAEQR 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1007 ---------------------------------ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLR---VDLE 1050
Cdd:pfam05557  172 ikelefeiqsqeqdseivknskselaripelekELERLREHNKHLNENIENKLLLKEEVEDLKRKLEREEKYReeaATLE 251
                          250       260
                   ....*....|....*....|....
gi 2462555497 1051 RNKRKLEGDL----KLAQESILDL 1070
Cdd:pfam05557  252 LEKEKLEQELqswvKLAQDTGLNL 275
PRK09039 PRK09039
peptidoglycan -binding protein;
1219-1376 1.44e-05

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 49.19  E-value: 1.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1219 EKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESI 1298
Cdd:PRK09039    52 DSALDRLNSQIAELADLLSLERQGNQDLQDSVANLRASLSAAEAERSRLQALLAELAGAGAAAEGRAGELAQELDSEKQV 131
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1299 VSQLSRSKQAFTQQTEELKRQLeeenkakNALAHALQSSrhdcdllrEQYEEEQEGKAE-----LQRALSKANSEVAQWR 1373
Cdd:PRK09039   132 SARALAQVELLNQQIAALRRQL-------AALEAALDAS--------EKRDRESQAKIAdlgrrLNVALAQRVQELNRYR 196

                   ...
gi 2462555497 1374 TKY 1376
Cdd:PRK09039   197 SEF 199
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
862-1084 1.74e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  862 DELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTER----AEDEEEINAEL 937
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAElaelEKEIAELRAEL 99
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  938 TAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQAlddlqaeEDK 1017
Cdd:COG4942    100 EAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAEL-------EAE 172
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462555497 1018 VNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKK 1084
Cdd:COG4942    173 RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
868-1210 1.78e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.91  E-value: 1.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  868 EAKRKELEEKLVTLVQEKNDLQLQVQAesenlldAEERCDQLiKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEde 947
Cdd:COG4913    609 RAKLAALEAELAELEEELAEAEERLEA-------LEAELDAL-QERREALQRLAEYSWDEIDVASAEREIAELEAELE-- 678
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  948 csELKKDIDDLEltlaKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLnkTKSK 1027
Cdd:COG4913    679 --RLDASSDDLA----ALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLE--LRAL 750
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1028 LEQQVEDLESSlEQEKKLRVDLERNKRKLEGDLKLAQESILDL--------ENDKQQLDERLKKKDfEYCQLQSKVEDEq 1099
Cdd:COG4913    751 LEERFAAALGD-AVERELRENLEERIDALRARLNRAEEELERAmrafnrewPAETADLDADLESLP-EYLALLDRLEED- 827
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1100 tlGL-QFQKKIKELQARIEELEEEIEAERATRA-KTEKQR----------SDYareleelserleeaGGVTSTQIELNKK 1167
Cdd:COG4913    828 --GLpEYEERFKELLNENSIEFVADLLSKLRRAiREIKERidplndslkrIPF--------------GPGRYLRLEARPR 891
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 2462555497 1168 REAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDN 1210
Cdd:COG4913    892 PDPEVREFRQELRAVTSGASLFDEELSEARFAALKRLIERLRS 934
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1478-1759 1.83e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1478 LSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAengKTIHELEKSRKQIELEKADIQlaleeaeaaleheea 1557
Cdd:COG4942     11 LALAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEK---ALLKQLAALERRIAALARRIR--------------- 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1558 kilriqlELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSrneairlkkkmeGDLNEIEIQLSHAN-RQ 1636
Cdd:COG4942     73 -------ALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRL------------GRQPPLALLLSPEDfLD 133
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1637 AAETLKHLRSVQGQLKDTqlhlddalrgQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQL 1716
Cdd:COG4942    134 AVRRLQYLKYLAPARREQ----------AEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLAR 203
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 2462555497 1717 LHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKA 1759
Cdd:COG4942    204 LEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
853-1334 2.08e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 49.79  E-value: 2.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  853 MKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESE---NLLDAEERCDQLIKAKFQLEAKIKEVTERAED 929
Cdd:pfam01576  550 LQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQlvsNLEKKQKKFDQMLAEEKAISARYAEERDRAEA 629
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  930 E------------------EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETI- 990
Cdd:pfam01576  630 EareketralslaraleeaLEAKEELERTNKQLRAEMEDLVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELq 709
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  991 ----AKLtREKKALQEAHQQALDDLQAEEDKVNslnKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQES 1066
Cdd:pfam01576  710 atedAKL-RLEVNMQALKAQFERDLQARDEQGE---EKRRQLVKQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQ 785
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1067 ILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQ-------TLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSD 1139
Cdd:pfam01576  786 IDAANKGREEAVKQLKKLQAQMKDLQRELEEARasrdeilAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDE 865
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1140 YARELeelserleeAGGVTSTQIELNKKR--EAEFLKLRRDLEEATLQHEAMVATLRK--KHADSV-AELGEQIDNLQRV 1214
Cdd:pfam01576  866 LADEI---------ASGASGKSALQDEKRrlEARIAQLEEELEEEQSNTELLNDRLRKstLQVEQLtTELAAERSTSQKS 936
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1215 ---KQKLEKEKSEFKL----------------------EIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQR 1269
Cdd:pfam01576  937 esaRQQLERQNKELKAklqemegtvkskfkssiaaleaKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQVEDERR 1016
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462555497 1270 SLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHAL 1334
Cdd:pfam01576 1017 HADQYKDQAEKGNSRMKQLKRQLEEAEEEASRANAARRKLQRELDDATESNESMNREVSTLKSKL 1081
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
935-1139 2.29e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 49.06  E-value: 2.29e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  935 AELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE 1014
Cdd:COG3883     19 QAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYRS 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1015 EDKVNSLN------------KTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLK 1082
Cdd:COG3883     99 GGSVSYLDvllgsesfsdflDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQA 178
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462555497 1083 KKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSD 1139
Cdd:COG3883    179 EQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAA 235
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
861-1113 2.79e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 49.24  E-value: 2.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  861 KDELAKSEAKRKELEEKL---VTLVQEKNDLQLQVQAESENLLDAEERCDQLIKA--KFQLEAKIKEVTERAED-EEEIn 934
Cdd:COG3206    106 DEDPLGEEASREAAIERLrknLTVEPVKGSNVIEISYTSPDPELAAAVANALAEAylEQNLELRREEARKALEFlEEQL- 184
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  935 AELTAKKRKLEDECSELKKD----------------IDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKk 998
Cdd:COG3206    185 PELRKELEEAEAALEEFRQKnglvdlseeaklllqqLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELLQSP- 263
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  999 ALQEAHQQaLDDLQAEEDKVNSLNKTKS----KLEQQVEDLESSLEQEkklrvdLERNKRKLEGDLKLAQESILDLENDK 1074
Cdd:COG3206    264 VIQQLRAQ-LAELEAELAELSARYTPNHpdviALRAQIAALRAQLQQE------AQRILASLEAELEALQAREASLQAQL 336
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 2462555497 1075 QQLDERLK---KKDFEYCQLQSKVEDEQTLGLQFQKKIKELQ 1113
Cdd:COG3206    337 AQLEARLAelpELEAELRRLEREVEVARELYESLLQRLEEAR 378
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
890-1513 3.77e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 49.07  E-value: 3.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  890 LQVQAESENLLDAEERCDQLIKAkfqleakIKEVTERAEDEEEINAELTAKKRkledecSELKKDIDDLELTLAKVEKEK 969
Cdd:pfam12128  244 TKLQQEFNTLESAELRLSHLHFG-------YKSDETLIASRQEERQETSAELN------QLLRTLDDQWKEKRDELNGEL 310
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  970 HATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRV-- 1047
Cdd:pfam12128  311 SAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQNnr 390
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1048 DLERNKRKL----EGDLKLAQESILDLENDKQQLDERLK--KKDFEYCQLQSKVEDEQTLGLQFQKKIK-ELQARIEELE 1120
Cdd:pfam12128  391 DIAGIKDKLakirEARDRQLAVAEDDLQALESELREQLEagKLEFNEEEYRLKSRLGELKLRLNQATATpELLLQLENFD 470
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1121 EEIEAERATRAKTEKQRSDYAreleelsERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEA----MVATLRKK 1196
Cdd:pfam12128  471 ERIERAREEQEAANAEVERLQ-------SELRQARKRRDQASEALRQASRRLEERQSALDELELQLFPqagtLLHFLRKE 543
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1197 HADSVAELGEQIDNLQRVKQKLEKEKSEF----------------KLEIDDLSSSMESVSKSKANLEKICRT-------L 1253
Cdd:pfam12128  544 APDWEQSIGKVISPELLHRTDLDPEVWDGsvggelnlygvkldlkRIDVPEWAASEEELRERLDKAEEALQSarekqaaA 623
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1254 EDQLSEARGKNEEIQRslsELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKA-KNALAH 1332
Cdd:pfam12128  624 EEQLVQANGELEKASR---EETFARTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSANERLNSLEAQLKQlDKKHQA 700
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1333 ALQSSRHDCDLLR---EQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQ---------------RTEELEEAKKKL 1394
Cdd:pfam12128  701 WLEEQKEQKREARtekQAYWQVVEGALDAQLALLKAAIAARRSGAKAELKALEtwykrdlaslgvdpdVIAKLKREIRTL 780
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1395 AQRLQDSEEQVEAV------------------NAKCASLEKTKQRLQGEVEDLMVDVERANS--------------LAAA 1442
Cdd:pfam12128  781 ERKIERIAVRRQEVlryfdwyqetwlqrrprlATQLSNIERAISELQQQLARLIADTKLRRAklemerkasekqqvRLSE 860
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462555497 1443 LDKKQRNFDKVLAEWKTKCEESQAELEASlkeSRSLSTELFKLKNAYEEaldqlETVKRENKNLEQEIADL 1513
Cdd:pfam12128  861 NLRGLRCEMSKLATLKEDANSEQAQGSIG---ERLAQLEDLKLKRDYLS-----ESVKKYVEHFKNVIADH 923
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
844-1087 3.98e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 48.35  E-value: 3.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  844 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEV 923
Cdd:pfam07888   76 RELESRVAELKEELRQSREKHEELEEKYKELSASSEELSEEKDALLAQRAAHEARIRELEEDIKTLTQRVLERETELERM 155
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  924 TERAE-------DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAK---L 993
Cdd:pfam07888  156 KERAKkagaqrkEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAEneaL 235
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  994 TREKKALQE---AHQQALDDLQAEEDKVNSL-NKTKSKLEQ-QVEDLESSLE------QEKKLRVDLERNKRKLEGDLKL 1062
Cdd:pfam07888  236 LEELRSLQErlnASERKVEGLGEELSSMAAQrDRTQAELHQaRLQAAQLTLQladaslALREGRARWAQERETLQQSAEA 315
                          250       260
                   ....*....|....*....|....*
gi 2462555497 1063 AQESILDLENDKQQLDERLKKKDFE 1087
Cdd:pfam07888  316 DKDRIEKLSAELQRLEERLQEERME 340
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1154-1383 4.33e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.84  E-value: 4.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1154 AGGVTSTQIELNKKREAEFLKLRRDLEEATlQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLS 1233
Cdd:COG4942     11 LALAAAAQADAAAEAEAELEQLQQEIAELE-KELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELE 89
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1234 SSMESVsksKANLEKICRTLEDQLSEA--RGKNEEIQ------------RSLSELTTQKSRLQTEAGELSRQLEEKESIV 1299
Cdd:COG4942     90 KEIAEL---RAELEAQKEELAELLRALyrLGRQPPLAlllspedfldavRRLQYLKYLAPARREQAEELRADLAELAALR 166
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1300 SQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD 1379
Cdd:COG4942    167 AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246

                   ....
gi 2462555497 1380 AIQR 1383
Cdd:COG4942    247 GFAA 250
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1565-1809 4.64e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.84  E-value: 4.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1565 ELTQVKSEIDRKIAEKDEEIEQLKRNyQRTVETMQSALDAEVRSRNEAIRlkkKMEGDLNEIEIQLSHANRQAAETLKHL 1644
Cdd:COG4942     24 EAEAELEQLQQEIAELEKELAALKKE-EKALLKQLAALERRIAALARRIR---ALEQELAALEAELAELEKEIAELRAEL 99
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1645 RSVQGQLKDtQLHLDDALRGQEDLK-----EQLAIVERRANLLQAEVEELRATLEQTERARklaeqelldsnervQLLHT 1719
Cdd:COG4942    100 EAQKEELAE-LLRALYRLGRQPPLAlllspEDFLDAVRRLQYLKYLAPARREQAEELRADL--------------AELAA 164
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1720 QNTSLIHTKKKLETDLMQLQSEvedasRDARNAEEKAKKAItdAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD 1799
Cdd:COG4942    165 LRAELEAERAELEALLAELEEE-----RAALEALKAERQKL--LARLEKELAELAAELAELQQEAEELEALIARLEAEAA 237
                          250
                   ....*....|
gi 2462555497 1800 EAEQLALKGG 1809
Cdd:COG4942    238 AAAERTPAAG 247
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1728-1927 5.20e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 48.37  E-value: 5.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1728 KKKLETDLMQLQSEVEDASRdARNAEEKAKKAI---TDAAMMAEELKKEQDTSAHLERMKKNL-----EQTVKDLQHRLD 1799
Cdd:COG4913    220 EPDTFEAADALVEHFDDLER-AHEALEDAREQIellEPIRELAERYAAARERLAELEYLRAALrlwfaQRRLELLEAELE 298
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1800 EAEQlALKGGKKQIQKLETRIRELEFELEG-EQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKS 1878
Cdd:COG4913    299 ELRA-ELARLEAELERLEARLDALREELDElEAQIRGNGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPA 377
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2462555497 1879 YKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRD 1927
Cdd:COG4913    378 SAEEFAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEA 426
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1160-1455 8.00e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 47.70  E-value: 8.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1160 TQIELNKKRE-----AEFLKLRRDLEEATLQHEAMVATLRKkhadsvaelgeqidnlqRVKQKLEKEKSEFKLEIDDlss 1234
Cdd:COG3206     85 TQIEILKSRPvlervVDKLNLDEDPLGEEASREAAIERLRK-----------------NLTVEPVKGSNVIEISYTS--- 144
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1235 smESVSKSKANLEKICRTLEDQLSEARgkNEEIQRSLSELTTQKSRLQTEAGELSRQLEE--KESIVSQLSRSKQAFTQQ 1312
Cdd:COG3206    145 --PDPELAAAVANALAEAYLEQNLELR--REEARKALEFLEEQLPELRKELEEAEAALEEfrQKNGLVDLSEEAKLLLQQ 220
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1313 TEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEE--EQEGKAELQRALSKANSEVAQWRTKYETD--AIQRT-EEL 1387
Cdd:COG3206    221 LSELESQLAEARAELAEAEARLAALRAQLGSGPDALPEllQSPVIQQLRAQLAELEAELAELSARYTPNhpDVIALrAQI 300
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462555497 1388 EEAKKKLAQR----LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLA 1455
Cdd:COG3206    301 AALRAQLQQEaqriLASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQ 372
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
845-1003 8.02e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.07  E-value: 8.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  845 ETEKEMATMKEEFQKTKDELAKSEAK----RKELEEKLVTLVQEKNDLQLQVQAESENLLDA--------------EERC 906
Cdd:COG4942     73 ALEQELAALEAELAELEKEIAELRAEleaqKEELAELLRALYRLGRQPPLALLLSPEDFLDAvrrlqylkylaparREQA 152
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  907 DQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEdecselkKDIDDLELTLAKVEKEKHATENKVKNLTEELSGL 986
Cdd:COG4942    153 EELRADLAELAALRAELEAERAELEALLAELEEERAALE-------ALKAERQKLLARLEKELAELAAELAELQQEAEEL 225
                          170
                   ....*....|....*..
gi 2462555497  987 DETIAKLTREKKALQEA 1003
Cdd:COG4942    226 EALIARLEAEAAAAAER 242
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1438-1679 9.38e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.07  E-value: 9.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1438 SLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI 1517
Cdd:COG4942     13 LAAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEI 92
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1518 AEngktihelekSRKQIELEKADIQLALEEAEAALEHEEAKILriqleltqVKSEIDRKIAEKDEEIEQLKRNYQRTVET 1597
Cdd:COG4942     93 AE----------LRAELEAQKEELAELLRALYRLGRQPPLALL--------LSPEDFLDAVRRLQYLKYLAPARREQAEE 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1598 MQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVER 1677
Cdd:COG4942    155 LRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEA 234

                   ..
gi 2462555497 1678 RA 1679
Cdd:COG4942    235 EA 236
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
847-1187 9.47e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 47.66  E-value: 9.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  847 EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESE---NLLDAEERCDQLIKAKFQLEAKIKEV 923
Cdd:TIGR00618  534 EQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEdipNLQNITVRLQDLTEKLSEAEDMLACE 613
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  924 TERAEDEEEI---NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAtenkvknlteelsgldetiaKLTREKKAL 1000
Cdd:TIGR00618  614 QHALLRKLQPeqdLQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHA--------------------LSIRVLPKE 673
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1001 QEAHQQALddLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLER-------NKRKLEGDLKLAQESILDLEnd 1073
Cdd:TIGR00618  674 LLASRQLA--LQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEienasssLGSDLAAREDALNQSLKELM-- 749
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1074 kQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEE 1153
Cdd:TIGR00618  750 -HQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQ 828
                          330       340       350
                   ....*....|....*....|....*....|....
gi 2462555497 1154 AGGVTSTQIELNKKREAEFLKLRRDLEEATLQHE 1187
Cdd:TIGR00618  829 EEEQFLSRLEEKSATLGEITHQLLKYEECSKQLA 862
PRK12704 PRK12704
phosphodiesterase; Provisional
890-1053 1.13e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 47.08  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  890 LQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEI---NAELTAKKRKLEDECSELKKDIDDLeltlakvE 966
Cdd:PRK12704    34 KEAEEEAKRILEEAKKEAEAIKKEALLEAKEEIHKLRNEFEKELrerRNELQKLEKRLLQKEENLDRKLELL-------E 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  967 KEKHATENKVKNLTEELSGLDETIAKLtrekKALQEAHQQALDD---LQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEK 1043
Cdd:PRK12704   107 KREEELEKKEKELEQKQQELEKKEEEL----EELIEEQLQELERisgLTAEEAKEILLEKVEEEARHEAAVLIKEIEEEA 182
                          170
                   ....*....|
gi 2462555497 1044 KLRVDLERNK 1053
Cdd:PRK12704   183 KEEADKKAKE 192
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1669-1924 1.40e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.97  E-value: 1.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1669 KEQLAIVE--RRANLLQAEVEELRATLEQ-------TERaRKLAEQELLDSNE---RVQLLHTQntslihTKKKLETdlM 1736
Cdd:TIGR02168  135 KRSYSIIEqgKISEIIEAKPEERRAIFEEaagiskyKER-RKETERKLERTREnldRLEDILNE------LERQLKS--L 205
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1737 QLQSEVEDASRDARNAEEKAKKAItdAAMMAEELKKEQDTsahLERMKKNLEQTVKDLQHRLDEAEQlalkggkkQIQKL 1816
Cdd:TIGR02168  206 ERQAEKAERYKELKAELRELELAL--LVLRLEELREELEE---LQEELKEAEEELEELTAELQELEE--------KLEEL 272
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1817 ETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLV-------DKLQVKVKSYKRQAEEADEQ 1889
Cdd:TIGR02168  273 RLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLeelesklDELAEELAELEEKLEELKEE 352
                          250       260       270
                   ....*....|....*....|....*....|....*
gi 2462555497 1890 ANAHLTKFRKAQHELEEAEERADIAESQVNKLRAK 1924
Cdd:TIGR02168  353 LESLEAELEELEAELEELESRLEELEEQLETLRSK 387
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
973-1329 1.44e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 46.87  E-value: 1.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  973 ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTK---------------------SKLEQQ 1031
Cdd:COG5185    172 LNQNLKKLEIFGLTLGLLKGISELKKAEPSGTVNSIKESETGNLGSESTLLEKakeiinieealkgfqdpeselEDLAQT 251
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1032 VEDLESSLEQEKKLRVDLERNKRKLEGDLK-LAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQ-FQKKI 1109
Cdd:COG5185    252 SDKLEKLVEQNTDLRLEKLGENAESSKRLNeNANNLIKQFENTKEKIAEYTKSIDIKKATESLEEQLAAAEAEQeLEESK 331
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1110 KELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREaEFLKLRRDLEEATLQHEAM 1189
Cdd:COG5185    332 RETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVGEVELSKSSEELDSFKDTIESTKE-SLDEIPQNQRGYAQEILAT 410
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1190 VATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQlSEARGKNEEIQR 1269
Cdd:COG5185    411 LEDTLKAADRQIEELQRQIEQATSSNEEVSKLLNELISELNKVMREADEESQSRLEEAYDEINRSVR-SKKEDLNEELTQ 489
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462555497 1270 SLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQ-QTEELKRQLEEENKAKNA 1329
Cdd:COG5185    490 IESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFMRaRGYAHILALENLIPASEL 550
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1347-1539 1.56e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.36  E-value: 1.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1347 QYEEEQEGKAELQRALSKANSEVAQWRTKYEtdaiqrteELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEV 1426
Cdd:COG3883     17 QIQAKQKELSELQAELEAAQAELDALQAELE--------ELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREEL 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1427 EDLMVDVER-------------ANSLAAALDK---------KQRNFDKVLAEWKTKCEESQAELEASLKEsrslsteLFK 1484
Cdd:COG3883     89 GERARALYRsggsvsyldvllgSESFSDFLDRlsalskiadADADLLEELKADKAELEAKKAELEAKLAE-------LEA 161
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462555497 1485 LKNAYEEALDQLETVKRENKN----LEQEIADLTEQIAENGKTIHELEKSRKQIELEKA 1539
Cdd:COG3883    162 LKAELEAAKAELEAQQAEQEAllaqLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220
PRK01156 PRK01156
chromosome segregation protein; Provisional
1414-1932 1.73e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.82  E-value: 1.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1414 SLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQ---RNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYE 1490
Cdd:PRK01156   163 SLERNYDKLKDVIDMLRAEISNIDYLEEKLKSSNlelENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALN 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1491 EALDQLETVKRENKNLEQEIADLTEQIAENGKtIHELEKSRKQIELEKA---------------DIQLALE--EAEAALE 1553
Cdd:PRK01156   243 ELSSLEDMKNRYESEIKTAESDLSMELEKNNY-YKELEERHMKIINDPVyknrnyindyfkyknDIENKKQilSNIDAEI 321
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1554 HEEAKILRIQLELTQVKSEIDRKIAEKDE------EIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIE 1627
Cdd:PRK01156   322 NKYHAIIKKLSVLQKDYNDYIKKKSRYDDlnnqilELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQE 401
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1628 IQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRAnllQAEVEELRATLEQTERARKLAEQEL 1707
Cdd:PRK01156   402 IDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQS---VCPVCGTTLGEEKSNHIINHYNEKK 478
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1708 LDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELK---------KEQDTSA 1778
Cdd:PRK01156   479 SRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKdkhdkyeeiKNRYKSL 558
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1779 HLERMKKNLEQTVKDLQHRLD---EAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESvkgLRKYERRVKELTYQS 1855
Cdd:PRK01156   559 KLEDLDSKRTSWLNALAVISLidiETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKS---IREIENEANNLNNKY 635
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462555497 1856 EEDRKNvlrlQDLVDKLQVKVKSYKRQAEEADEQanahltkfrkaQHELEEAEERADIAESQVNKLRAKTRDFTSSR 1932
Cdd:PRK01156   636 NEIQEN----KILIEKLRGKIDNYKKQIAEIDSI-----------IPDLKEITSRINDIEDNLKKSRKALDDAKANR 697
PRK11281 PRK11281
mechanosensitive channel MscK;
1265-1511 1.74e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 46.83  E-value: 1.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1265 EEIQRSLSELTTQKSrLQTEAGELSRQLEEKESIVSQLSRSKQaftqQTEELKRQL-----------EEENKAKNALAHA 1333
Cdd:PRK11281    39 ADVQAQLDALNKQKL-LEAEDKLVQQDLEQTLALLDKIDRQKE----ETEQLKQQLaqapaklrqaqAELEALKDDNDEE 113
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1334 LQSSRHDCDL--LREQYEEEQEGKAELQRALSKANSEVAQWRTKYE------TDAIQRTEELEEAKKKL-AQRLQDSEEQ 1404
Cdd:PRK11281   114 TRETLSTLSLrqLESRLAQTLDQLQNAQNDLAEYNSQLVSLQTQPEraqaalYANSQRLQQIRNLLKGGkVGGKALRPSQ 193
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1405 VEAVNAKCASLE-KTKQR---LQGevedlmvdveraNSLAAALDKKQRNFdkvLAEWKTKCEESQAELEASLKESRSLST 1480
Cdd:PRK11281   194 RVLLQAEQALLNaQNDLQrksLEG------------NTQLQDLLQKQRDY---LTARIQRLEHQLQLLQEAINSKRLTLS 258
                          250       260       270
                   ....*....|....*....|....*....|..
gi 2462555497 1481 ElfklkNAYEEALDQLETVK-RENKNLEQEIA 1511
Cdd:PRK11281   259 E-----KTVQEAQSQDEAARiQANPLVAQELE 285
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
956-1368 1.80e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 46.76  E-value: 1.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  956 DDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLnktKSKLEQQVEDL 1035
Cdd:pfam12128  600 EELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSE---KDKKNKALAER 676
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1036 ESSLEQEkklRVDLERNKRKLEGDLKLAQESILD--LENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQ 1113
Cdd:pfam12128  677 KDSANER---LNSLEAQLKQLDKKHQAWLEEQKEqkREARTEKQAYWQVVEGALDAQLALLKAAIAARRSGAKAELKALE 753
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1114 ARIEELEEEIEAERATRAKTEKQRSDYareleelserleeaggvtSTQIELNKKREAEFLKLRRDLEEATLQHE----AM 1189
Cdd:pfam12128  754 TWYKRDLASLGVDPDVIAKLKREIRTL------------------ERKIERIAVRRQEVLRYFDWYQETWLQRRprlaTQ 815
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1190 VATLRKKHADSVAELGEQIDNLQRVKQKLEKEKsefKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSE-ARGKNEEIQ 1268
Cdd:pfam12128  816 LSNIERAISELQQQLARLIADTKLRRAKLEMER---KASEKQQVRLSENLRGLRCEMSKLATLKEDANSEqAQGSIGERL 892
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1269 RSLSELttqKSRLQTEAGELSRQLEEKESIVSQLSRSkqAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQY 1348
Cdd:pfam12128  893 AQLEDL---KLKRDYLSESVKKYVEHFKNVIADHSGS--GLAETWESLREEDHYQNDKGIRLLDYRKLVPYLEQWFDVRV 967
                          410       420
                   ....*....|....*....|
gi 2462555497 1349 EEEQEGKAELQRALSKANSE 1368
Cdd:pfam12128  968 PQSIMVLREQVSILGVDLTE 987
PLN02939 PLN02939
transferase, transferring glycosyl groups
1644-1933 1.81e-04

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 46.82  E-value: 1.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1644 LRSVQGQLKDTQ---LHLDDA-LRGQEDLKEQLAivERRAnlLQAEVEELRATLEQTERARKLAEQElldsNERVQLLHT 1719
Cdd:PLN02939   130 LEDLVGMIQNAEkniLLLNQArLQALEDLEKILT--EKEA--LQGKINILEMRLSETDARIKLAAQE----KIHVEILEE 201
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1720 QntsLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTS---AHLERMKKNLEQTVKDLQH 1796
Cdd:PLN02939   202 Q---LEKLRNELLIRGATEGLCVHSLSKELDVLKEENMLLKDDIQFLKAELIEVAETEervFKLEKERSLLDASLRELES 278
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1797 RLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKY---ERRVKELTYQSEEdrKNVLRLQ-DLVDKL 1872
Cdd:PLN02939   279 KFIVAQEDVSKLSPLQYDCWWEKVENLQDLLDRATNQVEKAALVLDQNqdlRDKVDKLEASLKE--ANVSKFSsYKVELL 356
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462555497 1873 QVKVKSYKRQAEEADEQANAHLTKFrkaQHELEEAEeraDIAESQVNKLRAKTRDFTSSRM 1933
Cdd:PLN02939   357 QQKLKLLEERLQASDHEIHSYIQLY---QESIKEFQ---DTLSKLKEESKKRSLEHPADDM 411
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1254-1447 1.92e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 45.98  E-value: 1.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1254 EDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHA 1333
Cdd:COG3883     15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARA 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1334 LQSSRHDCDLL---------------REQYEEEQEGKAELQRALSKANSEVAQwrtkYETDAIQRTEELEEAKKKLAQRL 1398
Cdd:COG3883     95 LYRSGGSVSYLdvllgsesfsdfldrLSALSKIADADADLLEELKADKAELEA----KKAELEAKLAELEALKAELEAAK 170
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2462555497 1399 QDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQ 1447
Cdd:COG3883    171 AELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAA 219
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
844-968 1.98e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 44.92  E-value: 1.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  844 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKL--VTLVQEKNDLQLQVQAESENLLDAEercDQLIKAKFQLEAKIK 921
Cdd:COG1579     48 EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLgnVRNNKEYEALQKEIESLKRRISDLE---DEILELMERIEELEE 124
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 2462555497  922 EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKE 968
Cdd:COG1579    125 ELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAK 171
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
1265-1885 2.30e-04

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 46.33  E-value: 2.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1265 EEIQRSLSELTTQKSRLQTEAGELSRQLE---EKESIVSQLSRSKQAFTQQTEELkrqlEEENKAKNALAHALQSSRhdc 1341
Cdd:PRK10246   219 QSLTASLQVLTDEEKQLLTAQQQQQQSLNwltRLDELQQEASRRQQALQQALAAE----EKAQPQLAALSLAQPARQ--- 291
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1342 dlLREQYEEEQEGKAELQRALSKANS------EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSE------EQVEAVN 1409
Cdd:PRK10246   292 --LRPHWERIQEQSAALAHTRQQIEEvntrlqSTMALRARIRHHAAKQSAELQAQQQSLNTWLAEHDrfrqwnNELAGWR 369
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1410 AKCASLEKTKQRLQGEVEDLMVDVERANSLAAALdkkqrnfdkvlaewKTKCEESQAELEASLKESRSLSTELFKLKNAY 1489
Cdd:PRK10246   370 AQFSQQTSDREQLRQWQQQLTHAEQKLNALPAIT--------------LTLTADEVAAALAQHAEQRPLRQRLVALHGQI 435
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1490 EEALDQLETVKRENKNLEQEIADLTEQIAE-------------NGKTIHELEKSRKQIELEKADIQL------------- 1543
Cdd:PRK10246   436 VPQQKRLAQLQVAIQNVTQEQTQRNAALNEmrqrykektqqlaDVKTICEQEARIKDLEAQRAQLQAgqpcplcgstshp 515
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1544 -ALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRN---YQRTVETMQsALDAEVRSRNEAIRLKKKM 1619
Cdd:PRK10246   516 aVEAYQALEPGVNQSRLDALEKEVKKLGEEGAALRGQLDALTKQLQRDeseAQSLRQEEQ-ALTQQWQAVCASLNITLQP 594
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1620 EGDLN-------EIEIQLSHANR------QAAETLKHLRSVQGQLKDTQLHLDDALRG-------QEDLKEQLAIVERRA 1679
Cdd:PRK10246   595 QDDIQpwldaqeEHERQLRLLSQrhelqgQIAAHNQQIIQYQQQIEQRQQQLLTALAGyaltlpqEDEEASWLATRQQEA 674
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1680 NLLQAEVEELRATLEQTERARKL-----AEQELLDSNERVQL-----LHTQNTSL---IHTKKKLETDLMQLQSEVEDAS 1746
Cdd:PRK10246   675 QSWQQRQNELTALQNRIQQLTPLletlpQSDDLPHSEETVALdnwrqVHEQCLSLhsqLQTLQQQDVLEAQRLQKAQAQF 754
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1747 RDARNAEEKAKKAITDAAMMAEElkkeqdTSAHLERMKKNLEQtvkdlqhRLDEAEQLALKGGKKQIQKLETRIRELEFE 1826
Cdd:PRK10246   755 DTALQASVFDDQQAFLAALLDEE------TLTQLEQLKQNLEN-------QRQQAQTLVTQTAQALAQHQQHRPDGLDLT 821
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462555497 1827 LEGE--QKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDklqvKVKSYKRQAEE 1885
Cdd:PRK10246   822 VTVEqiQQELAQLAQQLRENTTRQGEIRQQLKQDADNRQQQQALMQ----QIAQATQQVED 878
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1161-1367 2.82e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.53  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1161 QIELNKKREAEFLKLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVS 1240
Cdd:COG4942     42 ELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPP 121
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1241 KS----KANLEKICRTLE--DQLSEARGKN-EEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQaftqQT 1313
Cdd:COG4942    122 LAlllsPEDFLDAVRRLQylKYLAPARREQaEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKA----ER 197
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462555497 1314 EELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANS 1367
Cdd:COG4942    198 QKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAAL 251
PRK11637 PRK11637
AmiB activator; Provisional
949-1079 2.83e-04

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 45.45  E-value: 2.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  949 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDL----------------- 1011
Cdd:PRK11637    71 ASLLAQLKKQEEAISQASRKLRETQNTLNQLNKQIDELNASIAKLEQQQAAQERLLAAQLDAAfrqgehtglqlilsgee 150
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1012 ---------------QAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEN---- 1072
Cdd:PRK11637   151 sqrgerilayfgylnQARQETIAELKQTREELAAQKAELEEKQSQQKTLLYEQQAQQQKLEQARNERKKTLTGLESslqk 230

                   ....*..
gi 2462555497 1073 DKQQLDE 1079
Cdd:PRK11637   231 DQQQLSE 237
mukB PRK04863
chromosome partition protein MukB;
848-1112 3.19e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 46.10  E-value: 3.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  848 KEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENL------LDAEERCDQLIKAKFQLEAKIK 921
Cdd:PRK04863   286 EEALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLnlvqtaLRQQEKIERYQADLEELEERLE 365
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  922 EVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL-------------------------------ELTLAKVEKEKH 970
Cdd:PRK04863   366 EQNEVVEEADEQQEENEARAEAAEEEVDELKSQLADYqqaldvqqtraiqyqqavqalerakqlcglpDLTADNAEDWLE 445
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  971 ATENKVKNLTEELSGLDETI----AKLTREKKALQ------------EAHQQALDDL-QAEEDKVnsLNKTKSKLEQQVE 1033
Cdd:PRK04863   446 EFQAKEQEATEELLSLEQKLsvaqAAHSQFEQAYQlvrkiagevsrsEAWDVARELLrRLREQRH--LAEQLQQLRMRLS 523
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462555497 1034 DLESSLEQEKklrvDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKEL 1112
Cdd:PRK04863   524 ELEQRLRQQQ----RAERLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRL 598
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
842-1087 3.24e-04

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 44.90  E-value: 3.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  842 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIK-------AKF 914
Cdd:COG1340      2 KTDELSSSLEELEEKIEELREEIEELKEKRDELNEELKELAEKRDELNAQVKELREEAQELREKRDELNEkvkelkeERD 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  915 QLEAKIKEVTERAEDEEEINAELTAKKRKLEdecsELKKDIDDLE-----------------LTLAKVEKEKHATE---- 973
Cdd:COG1340     82 ELNEKLNELREELDELRKELAELNKAGGSID----KLRKEIERLEwrqqtevlspeeekelvEKIKELEKELEKAKkale 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  974 --NKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLER 1051
Cdd:COG1340    158 knEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADELRKEADELHKEIVEAQEKADELHEEIIELQK 237
                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 2462555497 1052 NKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFE 1087
Cdd:COG1340    238 ELRELRKELKKLRKKQRALKREKEKEELEEKAEEIF 273
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
847-1037 3.65e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 45.60  E-value: 3.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  847 EKEMATMKEEFQKTKDEL-AKSEAKRKELEE----KLVTLVQEKNDLQLQVQAESENLldaEERCDQLIKAK-------F 914
Cdd:pfam12128  695 DKKHQAWLEEQKEQKREArTEKQAYWQVVEGaldaQLALLKAAIAARRSGAKAELKAL---ETWYKRDLASLgvdpdviA 771
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  915 QLEAKIKEVTERAEDEEEINAE------------------LTAKKRKLEDECSELKKD----IDDLELTLAKVEKEKHAT 972
Cdd:pfam12128  772 KLKREIRTLERKIERIAVRRQEvlryfdwyqetwlqrrprLATQLSNIERAISELQQQlarlIADTKLRRAKLEMERKAS 851
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462555497  973 ENKVKNLTEELSGLDETIAKLT--REKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLES 1037
Cdd:pfam12128  852 EKQQVRLSENLRGLRCEMSKLAtlKEDANSEQAQGSIGERLAQLEDLKLKRDYLSESVKKYVEHFKN 918
Filament pfam00038
Intermediate filament protein;
1274-1528 3.73e-04

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 44.91  E-value: 3.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1274 LTTQKSRLQTEAgelsRQLEEKESivSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQE 1353
Cdd:pfam00038   23 LEQQNKLLETKI----SELRQKKG--AEPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDNLRLAAEDFRQKYEDELN 96
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1354 GKAELQ---RALSKANSEVAQWRTKYETDAIQRTEEL-------EEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQ 1423
Cdd:pfam00038   97 LRTSAEndlVGLRKDLDEATLARVDLEAKIESLKEELaflkknhEEEVRELQAQVSDTQVNVEMDAARKLDLTSALAEIR 176
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1424 GEVEDLMvdveranslaaaldkkQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKREN 1503
Cdd:pfam00038  177 AQYEEIA----------------AKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIELQSLKKQK 240
                          250       260
                   ....*....|....*....|....*....
gi 2462555497 1504 KNLEQEIADLTE----QIAENGKTIHELE 1528
Cdd:pfam00038  241 ASLERQLAETEEryelQLADYQELISELE 269
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
911-1073 4.32e-04

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 45.23  E-value: 4.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  911 KAKFQLEAKIKEVTERAEDEEEIN-AELTAKKRKLEDECSELKKDIDDLELTLAKvekekhatenkvknlteelsgLDET 989
Cdd:COG2433    384 ELIEKELPEEEPEAEREKEHEERElTEEEEEIRRLEEQVERLEAEVEELEAELEE---------------------KDER 442
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  990 IAKLTRE-KKALQEAHQQALDD--LQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNK----RKLEgdlKL 1062
Cdd:COG2433    443 IERLERElSEARSEERREIRKDreISRLDREIERLERELEEERERIEELKRKLERLKELWKLEHSGElvpvKVVE---KF 519
                          170
                   ....*....|.
gi 2462555497 1063 AQESILDLEND 1073
Cdd:COG2433    520 TKEAIRRLEEE 530
mukB PRK04863
chromosome partition protein MukB;
981-1397 4.50e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 45.33  E-value: 4.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  981 EELSGLDETIAKLTREK---KALQEAHQQALDDLQAEEDkvnSLNKTKSKLEQQVEDLESSL----------EQEKKLRV 1047
Cdd:PRK04863   279 NERRVHLEEALELRRELytsRRQLAAEQYRLVEMARELA---ELNEAESDLEQDYQAASDHLnlvqtalrqqEKIERYQA 355
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1048 DLERNKRKLEGDL---KLAQESILDLENDKQQLDE---RLKKKDFEYcqlQSKVEDEQTLGLQFQKKIKELQarieelee 1121
Cdd:PRK04863   356 DLEELEERLEEQNevvEEADEQQEENEARAEAAEEevdELKSQLADY---QQALDVQQTRAIQYQQAVQALE-------- 424
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1122 eieaeratRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKReaeflKLrRDLEEATLQHEamvatlrkKHADSV 1201
Cdd:PRK04863   425 --------RAKQLCGLPDLTADNAEDWLEEFQAKEQEATEELLSLEQ-----KL-SVAQAAHSQFE--------QAYQLV 482
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1202 AELGEQID--NLQRVKQKLEKEKSEFKLEIDDLSSsmesvskskanlekicrtLEDQLSEARGKNEE---IQRSLSELTT 1276
Cdd:PRK04863   483 RKIAGEVSrsEAWDVARELLRRLREQRHLAEQLQQ------------------LRMRLSELEQRLRQqqrAERLLAEFCK 544
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1277 QKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE------ENKAKNALAHALQSSrhdCDLLREQYEE 1350
Cdd:PRK04863   545 RLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRQQLEQlqariqRLAARAPAWLAAQDA---LARLREQSGE 621
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462555497 1351 EQEGK----------AELQRALSKANSEVAqwrtkyetdaiQRTEELEEAKKKLAQR 1397
Cdd:PRK04863   622 EFEDSqdvteymqqlLERERELTVERDELA-----------ARKQALDEEIERLSQP 667
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1462-1618 4.59e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 43.76  E-value: 4.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1462 EESQAELEASLKEsrsLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAE------NGKTIHELEKSRKQIE 1535
Cdd:COG1579     23 EHRLKELPAELAE---LEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKyeeqlgNVRNNKEYEALQKEIE 99
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1536 LEKADIQL---ALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTV---ETMQSALDAEVRSR 1609
Cdd:COG1579    100 SLKRRISDledEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEaerEELAAKIPPELLAL 179

                   ....*....
gi 2462555497 1610 NEAIRLKKK 1618
Cdd:COG1579    180 YERIRKRKN 188
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
970-1224 4.66e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.75  E-value: 4.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  970 HATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSL----EQEKKL 1045
Cdd:COG4942     16 AAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELaeleKEIAEL 95
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1046 RVDLERNKRKLEGDLKLAQES-------ILDLENDKQQLDERLKKkdfeycqLQSKVEDEQTLGLQFQKKIKELQARIEE 1118
Cdd:COG4942     96 RAELEAQKEELAELLRALYRLgrqpplaLLLSPEDFLDAVRRLQY-------LKYLAPARREQAEELRADLAELAALRAE 168
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1119 leeeieaerATRAKTEKQRSdyareleelserleeaggvtstqielnkkrEAEFLKLRRDLEEATLQHEAMVATLRKK-- 1196
Cdd:COG4942    169 ---------LEAERAELEAL------------------------------LAELEEERAALEALKAERQKLLARLEKEla 209
                          250       260
                   ....*....|....*....|....*....
gi 2462555497 1197 -HADSVAELGEQIDNLQRVKQKLEKEKSE 1224
Cdd:COG4942    210 eLAAELAELQQEAEELEALIARLEAEAAA 238
PLN02939 PLN02939
transferase, transferring glycosyl groups
1395-1748 5.43e-04

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 45.28  E-value: 5.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1395 AQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQrnfdkvLAEWKTKCEESQAELEASLKE 1474
Cdd:PLN02939    63 SKLQSNTDENGQLENTSLRTVMELPQKSTSSDDDHNRASMQRDEAIAAIDNEQ------QTNSKDGEQLSDFQLEDLVGM 136
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1475 SRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEH 1554
Cdd:PLN02939   137 IQNAEKNILLLNQARLQALEDLEKILTEKEALQGKINILEMRLSETDARIKLAAQEKIHVEILEEQLEKLRNELLIRGAT 216
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1555 EEAKILRIQLELTQVKSEidrKIAEKDeEIEQLKRNYQRTVETMQSALDAEvrsrneaiRLKKKMEGDLNEIEIQLSHAN 1634
Cdd:PLN02939   217 EGLCVHSLSKELDVLKEE---NMLLKD-DIQFLKAELIEVAETEERVFKLE--------KERSLLDASLRELESKFIVAQ 284
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1635 rqaAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERAR------KLAEQELL 1708
Cdd:PLN02939   285 ---EDVSKLSPLQYDCWWEKVENLQDLLDRATNQVEKAALVLDQNQDLRDKVDKLEASLKEANVSKfssykvELLQQKLK 361
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 2462555497 1709 DSNERVQLLHTQNTSLI----HTKKKLETDLMQLQSEVEDASRD 1748
Cdd:PLN02939   362 LLEERLQASDHEIHSYIqlyqESIKEFQDTLSKLKEESKKRSLE 405
PRK12704 PRK12704
phosphodiesterase; Provisional
912-1084 5.85e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.77  E-value: 5.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  912 AKFQLEAKIKEVTERAE---DEEEINAELTAKKRKLEdecseLKKDIDDLEltlAKVEKEKHATENKVKNLteelsglde 988
Cdd:PRK12704    25 RKKIAEAKIKEAEEEAKrilEEAKKEAEAIKKEALLE-----AKEEIHKLR---NEFEKELRERRNELQKL--------- 87
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  989 tiakltrEKKALQeaHQQALDDlqaeedKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEgdLKLAQESIL 1068
Cdd:PRK12704    88 -------EKRLLQ--KEENLDR------KLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQL--QELERISGL 150
                          170
                   ....*....|....*.
gi 2462555497 1069 DLENDKQQLDERLKKK 1084
Cdd:PRK12704   151 TAEEAKEILLEKVEEE 166
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1473-1911 5.87e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 44.96  E-value: 5.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1473 KESRSLSTELFKLKNAYE----EALDQLETVKRENKNLEQEIADLTEQIAENGKTiheLEKSRKQIELEKADIQLALEEA 1548
Cdd:TIGR00618  187 AKKKSLHGKAELLTLRSQlltlCTPCMPDTYHERKQVLEKELKHLREALQQTQQS---HAYLTQKREAQEEQLKKQQLLK 263
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1549 EAALEHEEAKILRIQLELTQVKSEIDRK---IAEKDEEIEQLKRNYQRTVETMQSALDAEVRSR-NEAIRLKKKMEGDLN 1624
Cdd:TIGR00618  264 QLRARIEELRAQEAVLEETQERINRARKaapLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLmKRAAHVKQQSSIEEQ 343
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1625 EIEIQLSHA----NRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEV-----EELRATLEQ 1695
Cdd:TIGR00618  344 RRLLQTLHSqeihIRDAHEVATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQatidtRTSAFRDLQ 423
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1696 TERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLE-TDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQ 1774
Cdd:TIGR00618  424 GQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKIHlQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEP 503
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1775 dtsahLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQK-------KNTESVKGLRKYERR 1847
Cdd:TIGR00618  504 -----CPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKqraslkeQMQEIQQSFSILTQC 578
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462555497 1848 VKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERA 1911
Cdd:TIGR00618  579 DNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELA 642
COG4487 COG4487
Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];
1415-1599 6.03e-04

Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];


Pssm-ID: 443580 [Multi-domain]  Cd Length: 425  Bit Score: 44.55  E-value: 6.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1415 LEKTKQRLQGEVEDLMVDVE-RANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTElfklknAYEEAL 1493
Cdd:COG4487     24 VKQRRAEFEKELAERLADAAkREAALELAEAKAKAQLQEQVAEKDAEIAELRARLEAEERKKALAVAE------EKEKEL 97
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1494 DQLETVKRENknlEQEIADLTEQIAENGKTIHELE--KSRKQIELEKADIQLALEEAEAALEHEEAKilriQLELTQVK- 1570
Cdd:COG4487     98 AALQEALAEK---DAKLAELQAKELELLKKERELEdaKREAELTVEKERDEELDELKEKLKKEEEEK----QLAEKSLKv 170
                          170       180
                   ....*....|....*....|....*....
gi 2462555497 1571 SEIDRKIAEKDEEIEQLKRNYQRTVETMQ 1599
Cdd:COG4487    171 AEYEKQLKDMQEQIEELKRKKEQGSTQLQ 199
growth_prot_Scy NF041483
polarized growth protein Scy;
1254-1923 6.40e-04

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 44.82  E-value: 6.40e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1254 EDQLSEARGKNEEIQRSLSELTtqkSRLQTEAGELSRQLEekesivsqlsrskqaftQQTEELKRQLEEENKAKNALAHA 1333
Cdd:NF041483   592 EEALADARAEAERIRREAAEET---ERLRTEAAERIRTLQ-----------------AQAEQEAERLRTEAAADASAARA 651
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1334 lQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAiqrTEELEEAKKKLAQRLQDSEEQVEAVNAKcA 1413
Cdd:NF041483   652 -EGENVAVRLRSEAAAEAERLKSEAQESADRVRAEAAAAAERVGTEA---AEALAAAQEEAARRRREAEETLGSARAE-A 726
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1414 SLEKTKQRLQGEvedlmvdveranslaaaldkkqrnfdKVLAEWKTKCEESQAELEASLKESRSLSTELfkLKNAYEEAL 1493
Cdd:NF041483   727 DQERERAREQSE--------------------------ELLASARKRVEEAQAEAQRLVEEADRRATEL--VSAAEQTAQ 778
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1494 DQLETVKRENKNLEQEIADLtEQIAEngktiHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILR-IQLELTQVKSE 1572
Cdd:NF041483   779 QVRDSVAGLQEQAEEEIAGL-RSAAE-----HAAERTRTEAQEEADRVRSDAYAERERASEDANRLRReAQEETEAAKAL 852
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1573 IDRKIAEKDEEIEQLKRNYQRTVETMQS-ALDAEVRSRNEAIRLKKKMEGDLNEI--------EIQLSHANRQAAETLKH 1643
Cdd:NF041483   853 AERTVSEAIAEAERLRSDASEYAQRVRTeASDTLASAEQDAARTRADAREDANRIrsdaaaqaDRLIGEATSEAERLTAE 932
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1644 LRSVQGQLKDTQLHLDDALRGqedlkEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTS 1723
Cdd:NF041483   933 ARAEAERLRDEARAEAERVRA-----DAAAQAEQLIAEATGEAERLRAEAAETVGSAQQHAERIRTEAERVKAEAAAEAE 1007
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1724 LIHTKKKLETDLMqLQSEVEDASRDARNAEEKAKKAITDAAMMAEEL---------KKEQDTSAHLERM----KKNLEQT 1790
Cdd:NF041483  1008 RLRTEAREEADRT-LDEARKDANKRRSEAAEQADTLITEAAAEADQLtakaqeealRTTTEAEAQADTMvgaaRKEAERI 1086
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1791 VKDL---------QHRLDEAEQLAlkGGKKQIQKLETRIRELEFELEGE-----QKKNTESVKGLRKYERRVKELTYQSE 1856
Cdd:NF041483  1087 VAEAtvegnslveKARTDADELLV--GARRDATAIRERAEELRDRITGEieelhERARRESAEQMKSAGERCDALVKAAE 1164
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462555497 1857 EDRKnvlrlqdlvdklQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRA 1923
Cdd:NF041483  1165 EQLA------------EAEAKAKELVSDANSEASKVRIAAVKKAEGLLKEAEQKKAELVREAEKIKA 1219
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
915-1067 7.03e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 43.37  E-value: 7.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  915 QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTE---------ELSG 985
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEqlgnvrnnkEYEA 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  986 LDETIAKLTREKKALQEAHQQALDDLQAEEDKvnsLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQE 1065
Cdd:COG1579     94 LQKEIESLKRRISDLEDEILELMERIEELEEE---LAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAA 170

                   ..
gi 2462555497 1066 SI 1067
Cdd:COG1579    171 KI 172
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
818-1656 7.43e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 44.66  E-value: 7.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  818 NIRSFMNVKHWPWMKLFFKIKPLLKSAETEKemaTMKEEFQKT----KDELAK--SEAKRKELEEKLVTLVQEKNDLQLQ 891
Cdd:TIGR01612  932 SIEKFHNKQNILKEILNKNIDTIKESNLIEK---SYKDKFDNTlidkINELDKafKDASLNDYEAKNNELIKYFNDLKAN 1008
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  892 VQAESENLL----DAEERCDQLIKAKFQ------------LEAKIKEVTERAEDEEEINAELTAKK--RKLEDECSELKK 953
Cdd:TIGR01612 1009 LGKNKENMLyhqfDEKEKATNDIEQKIEdanknipnieiaIHTSIYNIIDEIEKEIGKNIELLNKEilEEAEINITNFNE 1088
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  954 DIDDLEL----TLAKVEKEKHATE-NKVKNlteELSGLDETIAKLTREKKALQEAHQQALDDLQAEedkVNSLNKTKSKL 1028
Cdd:TIGR01612 1089 IKEKLKHynfdDFGKEENIKYADEiNKIKD---DIKNLDQKIDHHIKALEEIKKKSENYIDEIKAQ---INDLEDVADKA 1162
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1029 EQQvEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQEsILDLENDKQQLdERLKKKDFEYcqlqskvedEQTLGLQFQKK 1108
Cdd:TIGR01612 1163 ISN-DDPEEIEKKIENIVTKIDKKKNIYDEIKKLLNE-IAEIEKDKTSL-EEVKGINLSY---------GKNLGKLFLEK 1230
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1109 IKElqarieeleeEIEAERATRAKTEKQRSDYARELEELSERLEEAGgvtstqIELNKKREAEFLKLRRDLEE----ATL 1184
Cdd:TIGR01612 1231 IDE----------EKKKSEHMIKAMEAYIEDLDEIKEKSPEIENEMG------IEMDIKAEMETFNISHDDDKdhhiISK 1294
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1185 QHEAMVATLRKKHADSVAELGEQiDNLQRVKQKLEKEKSEFK-------------------LEIDDLSSSMESVSKSKAN 1245
Cdd:TIGR01612 1295 KHDENISDIREKSLKIIEDFSEE-SDINDIKKELQKNLLDAQkhnsdinlylneianiyniLKLNKIKKIIDEVKEYTKE 1373
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1246 LEKICRTLEDQLSEARGKNEEIQRSLSeLTTQKSRLQTEA------GELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQ 1319
Cdd:TIGR01612 1374 IEENNKNIKDELDKSEKLIKKIKDDIN-LEECKSKIESTLddkdidECIKKIKELKNHILSEESNIDTYFKNADENNENV 1452
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1320 LEEENK---AKNALAHALQ------SSRHDCDL--LREQYEEEQEGKAELQR--ALSKANSEVAQWRTKYETDAIQRTEE 1386
Cdd:TIGR01612 1453 LLLFKNiemADNKSQHILKikkdnaTNDHDFNIneLKEHIDKSKGCKDEADKnaKAIEKNKELFEQYKKDVTELLNKYSA 1532
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1387 LEeAKKKLAQRLQDSE----EQVEAVNAKCASLEKTKQRL------QGEVEDLMVDVERANSLAAALDKKQRNFDKVLae 1456
Cdd:TIGR01612 1533 LA-IKNKFAKTKKDSEiiikEIKDAHKKFILEAEKSEQKIkeikkeKFRIEDDAAKNDKSNKAAIDIQLSLENFENKF-- 1609
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1457 wkTKCEESQAELEASLKESRSLSTELFKLknayeeALDQLETVKRENKNLEQEIADLTEQIAENGKTIHEleksrKQIEL 1536
Cdd:TIGR01612 1610 --LKISDIKKKINDCLKETESIEKKISSF------SIDSQDTELKENGDNLNSLQEFLESLKDQKKNIED-----KKKEL 1676
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1537 EKADiqlaleeaeaaleheeAKILRIQLELTQVKSEIDRKIAEK--------DEEIEQLKRNYQRTVETMQSAL---DAE 1605
Cdd:TIGR01612 1677 DELD----------------SEIEKIEIDVDQHKKNYEIGIIEKikeiaianKEEIESIKELIEPTIENLISSFntnDLE 1740
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462555497 1606 VRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL 1656
Cdd:TIGR01612 1741 GIDPNEKLEEYNTEIGDIYEEFIELYNIIAGCLETVSKEPITYDEIKNTRI 1791
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
926-1051 7.48e-04

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 43.90  E-value: 7.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  926 RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETI-AKLTREKKALQeah 1004
Cdd:cd22656    101 DDLADATDDEELEEAKKTIKALLDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQTALETLEKALkDLLTDEGGAIA--- 177
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462555497 1005 QQALDDLQAEEDKVN-----SLNKTKSKLEQQVEDLESSLEQEKKLRVDLER 1051
Cdd:cd22656    178 RKEIKDLQKELEKLNeeyaaKLKAKIDELKALIADDEAKLAAALRLIADLTA 229
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1169-1338 8.33e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.24  E-value: 8.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1169 EAEFLKLRRDLEEAtlqhEAMVATLRKKHADSVAELGEQIDNlqRVKQKLEKEKSEFKLEIDDLSSSMesvsksKANLEK 1248
Cdd:COG3206    225 ESQLAEARAELAEA----EARLAALRAQLGSGPDALPELLQS--PVIQQLRAQLAELEAELAELSARY------TPNHPD 292
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1249 IcRTLEDQLSEARGK-NEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKqaftQQTEELKRQLEEENKAK 1327
Cdd:COG3206    293 V-IALRAQIAALRAQlQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELE----AELRRLEREVEVARELY 367
                          170
                   ....*....|.
gi 2462555497 1328 NALAHALQSSR 1338
Cdd:COG3206    368 ESLLQRLEEAR 378
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1063-1291 8.33e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.98  E-value: 8.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1063 AQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRsdyAR 1142
Cdd:COG4942     18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEI---AE 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1143 ELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEAtLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 1222
Cdd:COG4942     95 LRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDA-VRRLQYLKYLAPARREQAEELRADLAELAALRAELEAER 173
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462555497 1223 SEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ 1291
Cdd:COG4942    174 AELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
1682-1765 8.78e-04

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 44.56  E-value: 8.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1682 LQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARnaeEKAKKAIT 1761
Cdd:PRK11448   147 LQQEVLTLKQQLELQAREKAQSQALAEAQQQELVALEGLAAELEEKQQELEAQLEQLQEKAAETSQERK---QKRKEITD 223

                   ....
gi 2462555497 1762 DAAM 1765
Cdd:PRK11448   224 QAAK 227
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1565-1778 8.88e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.67  E-value: 8.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1565 ELTQVKSEIDRKIAEKDEEIEQLKRNYQRtvetmqsaLDAEVRSRNEAIrlkKKMEGDLNEIEIQLSHANRQAAETLKHL 1644
Cdd:COG3883     27 ELQAELEAAQAELDALQAELEELNEEYNE--------LQAELEALQAEI---DKLQAEIAEAEAEIEERREELGERARAL 95
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1645 rsvqgQLKDTQLHLDDALRGQEDLKEQLaiveRRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSL 1724
Cdd:COG3883     96 -----YRSGGSVSYLDVLLGSESFSDFL----DRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAEL 166
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462555497 1725 IHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSA 1778
Cdd:COG3883    167 EAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAA 220
46 PHA02562
endonuclease subunit; Provisional
1404-1597 9.60e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 44.23  E-value: 9.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1404 QVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAA-LDKKQRNFDKVLAE---WKTKCEESQAELEASLKESRSLS 1479
Cdd:PHA02562   175 KIRELNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGEnIARKQNKYDELVEEaktIKAEIEELTDELLNLVMDIEDPS 254
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1480 TELFKLKNAYEEALDQLETVKRENK-------------NLEQE---IADLTEQIAENGKTIHELEKSR---KQIELEKAD 1540
Cdd:PHA02562   255 AALNKLNTAAAKIKSKIEQFQKVIKmyekggvcptctqQISEGpdrITKIKDKLKELQHSLEKLDTAIdelEEIMDEFNE 334
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1541 IQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAE---KDEEIEQLKRNYQRTVET 1597
Cdd:PHA02562   335 QSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEfvdNAEELAKLQDELDKIVKT 394
mukB PRK04863
chromosome partition protein MukB;
1187-1429 9.93e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 44.18  E-value: 9.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1187 EAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKekseFKLEIDDLSSSMESVSKSKAN-LEKICRTLEDQLSEARGKNE 1265
Cdd:PRK04863   836 EAELRQLNRRRVELERALADHESQEQQQRSQLEQ----AKEGLSALNRLLPRLNLLADEtLADRVEEIREQLDEAEEAKR 911
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1266 EIQR---SLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQ---AFTQ--------QTEELKRQLEEENKAKNALA 1331
Cdd:PRK04863   912 FVQQhgnALAQLEPIVSVLQSDPEQFEQLKQDYQQAQQTQRDAKQqafALTEvvqrrahfSYEDAAEMLAKNSDLNEKLR 991
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1332 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEvaqWRTKYET--DAIQRTEEL-----EEAKKKLAQRLQDSEEQ 1404
Cdd:PRK04863   992 QRLEQAEQERTRAREQLRQAQAQLAQYNQVLASLKSS---YDAKRQMlqELKQELQDLgvpadSGAEERARARRDELHAR 1068
                          250       260
                   ....*....|....*....|....*
gi 2462555497 1405 VEAVNAKCASLEKTKQRLQGEVEDL 1429
Cdd:PRK04863  1069 LSANRSRRNQLEKQLTFCEAEMDNL 1093
PRK12704 PRK12704
phosphodiesterase; Provisional
1745-1915 1.09e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 44.00  E-value: 1.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1745 ASRDARNAEEKAKKAITDAAMMAEELKKEqdtsahlermkKNLEqtVKDLQHRL-DEAEQlALKGGKKQIQKLETRIREL 1823
Cdd:PRK12704    29 AEAKIKEAEEEAKRILEEAKKEAEAIKKE-----------ALLE--AKEEIHKLrNEFEK-ELRERRNELQKLEKRLLQK 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1824 EFELEgeqkkntesvKGLRKYERRVKELtyqsEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQAnAHLTKFRKAQHE 1903
Cdd:PRK12704    95 EENLD----------RKLELLEKREEEL----EKKEKELEQKQQELEKKEEELEELIEEQLQELERI-SGLTAEEAKEIL 159
                          170
                   ....*....|....
gi 2462555497 1904 LEEAEE--RADIAE 1915
Cdd:PRK12704   160 LEKVEEeaRHEAAV 173
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1161-1425 1.10e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 43.96  E-value: 1.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1161 QIELNKKREAEFLKLRRDLEEATLQHEAMV---ATLRKKHADSVAELGEQIDNLQRVKQKLEKEK---SEFKLEIDDLSS 1234
Cdd:pfam17380  300 RLRQEKEEKAREVERRRKLEEAEKARQAEMdrqAAIYAEQERMAMERERELERIRQEERKRELERirqEEIAMEISRMRE 379
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1235 SMESVSKSKANLEKICRTLEdQLSEARGKNEEIQRSLSELTTQKSRLQTEAG-----ELSRQLEEKESIVSQLSRSKQAF 1309
Cdd:pfam17380  380 LERLQMERQQKNERVRQELE-AARKVKILEEERQRKIQQQKVEMEQIRAEQEearqrEVRRLEEERAREMERVRLEEQER 458
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1310 TQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAE-----------LQRALSKANSEVAQWRTKYET 1378
Cdd:pfam17380  459 QQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQamieeerkrklLEKEMEERQKAIYEEERRREA 538
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 2462555497 1379 DAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGE 1425
Cdd:pfam17380  539 EEERRKQQEMEERRRIQEQMRKATEERSRLEAMEREREMMRQIVESE 585
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1288-1539 1.11e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.85  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1288 LSRQLEEKesiVSQLSRSKQAFTQQTEELKRQLEEenkAKNALAHALQssRHDCDLLREQYEEEQEGKAELQRALSKANS 1367
Cdd:COG3206    162 LEQNLELR---REEARKALEFLEEQLPELRKELEE---AEAALEEFRQ--KNGLVDLSEEAKLLLQQLSELESQLAEARA 233
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1368 EVAQWRTKYetDAIQRteELEEAKKKLAQRLQDSEEQveavnakcaSLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQ 1447
Cdd:COG3206    234 ELAEAEARL--AALRA--QLGSGPDALPELLQSPVIQ---------QLRAQLAELEAELAELSARYTPNHPDVIALRAQI 300
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1448 RNFDKVLaewktkceesQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHEL 1527
Cdd:COG3206    301 AALRAQL----------QQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESL 370
                          250
                   ....*....|..
gi 2462555497 1528 EKSRKQIELEKA 1539
Cdd:COG3206    371 LQRLEEARLAEA 382
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1713-1894 1.32e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.60  E-value: 1.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1713 RVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQdtsAHLERMKKNLEQ--T 1790
Cdd:COG1579     11 DLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVE---ARIKKYEEQLGNvrN 87
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1791 VKDLQHRLDEAEQLalkggKKQIQKLETRIRELEFELEGEQKKntesvkgLRKYERRVKELTYQSEEDRKnvlRLQDLVD 1870
Cdd:COG1579     88 NKEYEALQKEIESL-----KRRISDLEDEILELMERIEELEEE-------LAELEAELAELEAELEEKKA---ELDEELA 152
                          170       180
                   ....*....|....*....|....
gi 2462555497 1871 KLQVKVKSYKRQAEEADEQANAHL 1894
Cdd:COG1579    153 ELEAELEELEAEREELAAKIPPEL 176
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
857-1080 1.34e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 43.67  E-value: 1.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  857 FQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIK-----------AKFQLEAKIKEVTE 925
Cdd:PRK04778   100 FRKAKHEINEIESLLDLIEEDIEQILEELQELLESEEKNREEVEQLKDLYRELRKsllanrfsfgpALDELEKQLENLEE 179
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  926 RAEDEEEINAE---LTAKK--RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN----LTEELSGLDETiaKLTRE 996
Cdd:PRK04778   180 EFSQFVELTESgdyVEAREilDQLEEELAALEQIMEEIPELLKELQTELPDQLQELKAgyreLVEEGYHLDHL--DIEKE 257
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  997 KKALQEAHQQALDDLQAEE-DKVNSLNKtksKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQ 1075
Cdd:PRK04778   258 IQDLKEQIDENLALLEELDlDEAEEKNE---EIQERIDQLYDILEREVKARKYVEKNSDTLPDFLEHAKEQNKELKEEID 334

                   ....*
gi 2462555497 1076 QLDER 1080
Cdd:PRK04778   335 RVKQS 339
PspA_IM30 pfam04012
PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent ...
1674-1828 1.43e-03

PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homolog in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator.


Pssm-ID: 461130 [Multi-domain]  Cd Length: 215  Bit Score: 41.97  E-value: 1.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1674 IVERRANLLQAEVEELratLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETdlmqlqsEVEDASRDARNAE 1753
Cdd:pfam04012    1 IFKRLGRLVRANIHEG---LDKAEDPEKMLEQAIRDMQSELVKARQALAQTIARQKQLER-------RLEQQTEQAKKLE 70
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462555497 1754 EKAKKAITDAAmmaEELKKEqdtsahLERMKKNLEQTVKDLQHRLDEAEQLALKGgKKQIQKLETRIRELEFELE 1828
Cdd:pfam04012   71 EKAQAALTKGN---EELARE------ALAEKKSLEKQAEALETQLAQQRSAVEQL-RKQLAALETKIQQLKAKKN 135
PRK00106 PRK00106
ribonuclease Y;
865-1048 1.47e-03

ribonuclease Y;


Pssm-ID: 178867 [Multi-domain]  Cd Length: 535  Bit Score: 43.32  E-value: 1.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  865 AKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINA---ELTAKK 941
Cdd:PRK00106    24 IKMKSAKEAAELTLLNAEQEAVNLRGKAERDAEHIKKTAKRESKALKKELLLEAKEEARKYREEIEQEFKSerqELKQIE 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  942 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEElsglDETIAKLTREKkalqEAHQQALDDLQAEEDKVNSL 1021
Cdd:PRK00106   104 SRLTERATSLDRKDENLSSKEKTLESKEQSLTDKSKHIDER----EEQVEKLEEQK----KAELERVAALSQAEAREIIL 175
                          170       180
                   ....*....|....*....|....*..
gi 2462555497 1022 NKTKSKLEQQVEDLESSLEQEKKLRVD 1048
Cdd:PRK00106   176 AETENKLTHEIATRIREAEREVKDRSD 202
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1456-1709 1.50e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 43.57  E-value: 1.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1456 EWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALD--QLETVKRENKNLEQEiadlteQIAENGKTIHELEksRKQ 1533
Cdd:pfam17380  313 ERRRKLEEAEKARQAEMDRQAAIYAEQERMAMERERELEriRQEERKRELERIRQE------EIAMEISRMRELE--RLQ 384
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1534 IELEkadiQLALEEAEAALEHEEAKILriqleltqvKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAI 1613
Cdd:pfam17380  385 MERQ----QKNERVRQELEAARKVKIL---------EEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERV 451
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1614 RLKkkmegdlnEIEIQlshanrqaaETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQlaiverRANLLQAEVEELRATL 1693
Cdd:pfam17380  452 RLE--------EQERQ---------QQVERLRQQEEERKRKKLELEKEKRDRKRAEEQ------RRKILEKELEERKQAM 508
                          250
                   ....*....|....*.
gi 2462555497 1694 EQTERARKLAEQELLD 1709
Cdd:pfam17380  509 IEEERKRKLLEKEMEE 524
PspA COG1842
Phage shock protein A [Transcription, Signal transduction mechanisms];
1674-1824 1.51e-03

Phage shock protein A [Transcription, Signal transduction mechanisms];


Pssm-ID: 441447 [Multi-domain]  Cd Length: 217  Bit Score: 42.12  E-value: 1.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1674 IVERRANLLQAEVEELratLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDAsrdarnaE 1753
Cdd:COG1842      2 IFKRLSDIIRANINAL---LDKAEDPEKMLDQAIRDMEEDLVEARQALAQVIANQKRLERQLEELEAEAEKW-------E 71
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462555497 1754 EKAKKAitdaammaeeLKKEQDTSAH--LERmKKNLEQTVKDLQHRLDEAEQLALKGgKKQIQKLETRIRELE 1824
Cdd:COG1842     72 EKARLA----------LEKGREDLAReaLER-KAELEAQAEALEAQLAQLEEQVEKL-KEALRQLESKLEELK 132
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1251-1520 1.61e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 1.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1251 RTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNAL 1330
Cdd:COG4372     48 EQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDL 127
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1331 AHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNA 1410
Cdd:COG4372    128 EQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEK 207
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1411 KcASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYE 1490
Cdd:COG4372    208 L-IESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELE 286
                          250       260       270
                   ....*....|....*....|....*....|
gi 2462555497 1491 EALDQLETVKRENKNLEQEIADLTEQIAEN 1520
Cdd:COG4372    287 ALEEAALELKLLALLLNLAALSLIGALEDA 316
mukB PRK04863
chromosome partition protein MukB;
1251-1537 1.70e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 43.41  E-value: 1.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1251 RTLEDQLSEARGkneEIQRSLSELTTQKSRLqteaGELSRQLEEkesivsqLSRSKQAFTQQTEELKRQLeeeNKAKNAL 1330
Cdd:PRK04863   282 RVHLEEALELRR---ELYTSRRQLAAEQYRL----VEMARELAE-------LNEAESDLEQDYQAASDHL---NLVQTAL 344
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1331 AHALQSSRHDCDL------LREQ---YEEEQEGKAELQRALSKANSEVAQWRTKY----------ETDAIQ--------- 1382
Cdd:PRK04863   345 RQQEKIERYQADLeeleerLEEQnevVEEADEQQEENEARAEAAEEEVDELKSQLadyqqaldvqQTRAIQyqqavqale 424
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1383 ------------------RTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDlmVDVERANSLAAALD 1444
Cdd:PRK04863   425 rakqlcglpdltadnaedWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGE--VSRSEAWDVARELL 502
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1445 KKQRNfDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTI 1524
Cdd:PRK04863   503 RRLRE-QRHLAEQLQQLRMRLSELEQRLRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERR 581
                          330
                   ....*....|...
gi 2462555497 1525 HELEKSRKQIELE 1537
Cdd:PRK04863   582 MALRQQLEQLQAR 594
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
841-971 1.71e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 43.31  E-value: 1.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  841 LKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVqaesenlldaeERCDQLIKakfQLEAKI 920
Cdd:COG2433    385 LIEKELPEEEPEAEREKEHEERELTEEEEEIRRLEEQVERLEAEVEELEAEL-----------EEKDERIE---RLEREL 450
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462555497  921 KEVTERAEDEEEINAELTAKKRK---LEDECSELKKDIDDLEltlAKVEKEKHA 971
Cdd:COG2433    451 SEARSEERREIRKDREISRLDREierLERELEEERERIEELK---RKLERLKEL 501
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
1254-1737 1.80e-03

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 43.02  E-value: 1.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1254 EDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHA 1333
Cdd:COG5185    155 EVETGIIKDIFGKLTQELNQNLKKLEIFGLTLGLLKGISELKKAEPSGTVNSIKESETGNLGSESTLLEKAKEIINIEEA 234
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1334 LQSsrhdcdllREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEavnakca 1413
Cdd:COG5185    235 LKG--------FQDPESELEDLAQTSDKLEKLVEQNTDLRLEKLGENAESSKRLNENANNLIKQFENTKEKIA------- 299
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1414 slEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSlstelfklknayeeal 1493
Cdd:COG5185    300 --EYTKSIDIKKATESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENLEAIKE---------------- 361
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1494 dqletvKRENKNLEQEIADLTEQIAENGKTIhelEKSRKQIELEKADIQLALEEAEAAleheeakilriqleLTQVKSEI 1573
Cdd:COG5185    362 ------EIENIVGEVELSKSSEELDSFKDTI---ESTKESLDEIPQNQRGYAQEILAT--------------LEDTLKAA 418
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1574 DRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAI-RLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLK 1652
Cdd:COG5185    419 DRQIEELQRQIEQATSSNEEVSKLLNELISELNKVMREADeESQSRLEEAYDEINRSVRSKKEDLNEELTQIESRVSTLK 498
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1653 DTQLHLDDALRGQ-EDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKL 1731
Cdd:COG5185    499 ATLEKLRAKLERQlEGVRSKLDQVAESLKDFMRARGYAHILALENLIPASELIQASNAKTDGQAANLRTAVIDELTQYLS 578

                   ....*.
gi 2462555497 1732 ETDLMQ 1737
Cdd:COG5185    579 TIESQQ 584
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1228-1417 1.80e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 42.89  E-value: 1.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1228 EIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQ 1307
Cdd:COG3883     17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALY 96
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1308 --------------------------AFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRA 1361
Cdd:COG3883     97 rsggsvsyldvllgsesfsdfldrlsALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQ 176
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462555497 1362 LSKANSEVAQWRTKyETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEK 1417
Cdd:COG3883    177 QAEQEALLAQLSAE-EAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAA 231
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
1668-1836 1.82e-03

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 41.94  E-value: 1.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1668 LKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASR 1747
Cdd:pfam00261   48 LEEELERTEERLAEALEKLEEAEKAADESERGRKVLENRALKDEEKMEILEAQLKEAKEIAEEADRKYEEVARKLVVVEG 127
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1748 DARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE-------RMKKNLEQTVKDLQHRLDEAEQLALKgGKKQIQKLETRI 1820
Cdd:pfam00261  128 DLERAEERAELAESKIVELEEELKVVGNNLKSLEaseekasEREDKYEEQIRFLTEKLKEAETRAEF-AERSVQKLEKEV 206
                          170
                   ....*....|....*.
gi 2462555497 1821 RELEFELEGEQKKNTE 1836
Cdd:pfam00261  207 DRLEDELEAEKEKYKA 222
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
1572-1940 1.94e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.58  E-value: 1.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1572 EIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQL 1651
Cdd:COG4372      3 RLGEKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEEL 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1652 KDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKL 1731
Cdd:COG4372     83 EELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESL 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1732 ETDLMQLQSEVEdaSRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKK 1811
Cdd:COG4372    163 QEELAALEQELQ--ALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLD 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1812 QIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQAN 1891
Cdd:COG4372    241 ALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAA 320
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 2462555497 1892 AHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE 1940
Cdd:COG4372    321 LLELAKKLELALAILLAELADLLQLLLVGLLDNDVLELLSKGAEAGVAD 369
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
836-1051 1.99e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 43.11  E-value: 1.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  836 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQ 915
Cdd:PRK02224   497 RLERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAE 576
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  916 LEAKIKEVTERAEDEEEInAELTAKKRKLEDECSELKKDIDDleltLAKVEKEKhatENKVKNLTEELSGLDETIAKLTR 995
Cdd:PRK02224   577 LNSKLAELKERIESLERI-RTLLAAIADAEDEIERLREKREA----LAELNDER---RERLAEKRERKRELEAEFDEARI 648
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462555497  996 EKkaLQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLER 1051
Cdd:PRK02224   649 EE--AREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELEELRERREA 702
COG6 smart01087
Conserved oligomeric complex COG6; COG6 is a component of the conserved oligomeric golgi ...
1373-1506 2.01e-03

Conserved oligomeric complex COG6; COG6 is a component of the conserved oligomeric golgi complex, which is composed of eight different subunits and is required for normal golgi morphology and localisation.


Pssm-ID: 215018  Cd Length: 598  Bit Score: 43.08  E-value: 2.01e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  1373 RTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQrnfdK 1452
Cdd:smart01087    9 RSDLEKRLLKINGEFLSEFKPVAEQLQRLSEDVQKLNNSCDSMKDQLNTAKNQTQDLISEASELQEELALLELKK----K 84
                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2462555497  1453 VLAEWKTKCEESQAELEASLKESRSLSTELFKlknayeeALDQLETVKRENKNL 1506
Cdd:smart01087   85 LLDAFLSKFTLSQDELDVLTSREGPIDDEFFQ-------VLDKVQEIHEDCSVL 131
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
836-1094 2.03e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 42.49  E-value: 2.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  836 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEeRCDQLIKAKF- 914
Cdd:pfam15905   68 NLKESKDQKELEKEIRALVQERGEQDKRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQLLELT-RVNELLKAKFs 146
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  915 ------QLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD-------IDDLELTLAKVEKEKHATENKVKNLTE 981
Cdd:pfam15905  147 edgtqkKMSSLSMELMKLRNKLEAKMKEVMAKQEGMEGKLQVTQKNlehskgkVAQLEEKLVSTEKEKIEEKSETEKLLE 226
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  982 ELSGLDETIAKLTREKKALQeahqQALDDLQAEEDKVNSLnktKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLegdLK 1061
Cdd:pfam15905  227 YITELSCVSEQVEKYKLDIA----QLEELLKEKNDEIESL---KQSLEEKEQELSKQIKDLNEKCKLLESEKEEL---LR 296
                          250       260       270
                   ....*....|....*....|....*....|...
gi 2462555497 1062 LAQESILDLENDKQQLDERLKKKDFEYCQLQSK 1094
Cdd:pfam15905  297 EYEEKEQTLNAELEELKEKLTLEEQEHQKLQQK 329
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
842-1395 2.04e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 43.29  E-value: 2.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  842 KSAETEKEMATMKEEFQKTKDELAKSEA-KRKELEEKLVTLVQEKNDLQlQVQAESENL---LDAEERCDQLIKAKFQ-L 916
Cdd:pfam12128  302 KRDELNGELSAADAAVAKDRSELEALEDqHGAFLDADIETAAADQEQLP-SWQSELENLeerLKALTGKHQDVTAKYNrR 380
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  917 EAKIKEvtERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLakvekeKHATENKVKNLTEELSGLDETIAKLtre 996
Cdd:pfam12128  381 RSKIKE--QNNRDIAGIKDKLAKIREARDRQLAVAEDDLQALESEL------REQLEAGKLEFNEEEYRLKSRLGEL--- 449
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  997 kKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQ---QVEDLESSLEQEKKLRvdlERNKRKLEGDLKLAQESILDLEND 1073
Cdd:pfam12128  450 -KLRLNQATATPELLLQLENFDERIERAREEQEAanaEVERLQSELRQARKRR---DQASEALRQASRRLEERQSALDEL 525
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1074 KQQLD---------------------------ERLKKKDFEYCQLQSKVEDEQTLG---LQFQK--------KIKELQAR 1115
Cdd:pfam12128  526 ELQLFpqagtllhflrkeapdweqsigkvispELLHRTDLDPEVWDGSVGGELNLYgvkLDLKRidvpewaaSEEELRER 605
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1116 IEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAG----GVTSTQIELNKKREAEFLKLRRDLEEA--------- 1182
Cdd:pfam12128  606 LDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARtalkNARLDLRRLFDEKQSEKDKKNKALAERkdsanerln 685
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1183 TLQHEAMVatLRKKHADSVAELGEQI-------------------DNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSK 1243
Cdd:pfam12128  686 SLEAQLKQ--LDKKHQAWLEEQKEQKreartekqaywqvvegaldAQLALLKAAIAARRSGAKAELKALETWYKRDLASL 763
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1244 -------ANLEKICRTLEDQLSEARGKNEEIqrsLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEEL 1316
Cdd:pfam12128  764 gvdpdviAKLKREIRTLERKIERIAVRRQEV---LRYFDWYQETWLQRRPRLATQLSNIERAISELQQQLARLIADTKLR 840
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1317 KRQLEEENKAKNALAHALQSSRHDCDLLREQYEE--EQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1394
Cdd:pfam12128  841 RAKLEMERKASEKQQVRLSENLRGLRCEMSKLATlkEDANSEQAQGSIGERLAQLEDLKLKRDYLSESVKKYVEHFKNVI 920

                   .
gi 2462555497 1395 A 1395
Cdd:pfam12128  921 A 921
Caldesmon pfam02029
Caldesmon;
855-1111 2.05e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 42.93  E-value: 2.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  855 EEFQKTKDELAKSEAKR-KELEEKLvtlvQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEI 933
Cdd:pfam02029   59 DEEEAFLDRTAKREERRqKRLQEAL----ERQKEFDPTIADEKESVAERKENNEEEENSSWEKEEKRDSRLGRYKEEETE 134
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  934 NAELTAKKRKLEDECSELK---KDIDDLELTLAKVEKEKHATEN-KVKNLTEELSGLDETIAKLTREKKALQEAHQQALD 1009
Cdd:pfam02029  135 IREKEYQENKWSTEVRQAEeegEEEEDKSEEAEEVPTENFAKEEvKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQNGEE 214
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1010 DLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKL----RVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKD 1085
Cdd:pfam02029  215 EVTKLKVTTKRRQGGLSQSQEREEEAEVFLEAEQKLeelrRRRQEKESEEFEKLRQKQQEAELELEELKKKREERRKLLE 294
                          250       260
                   ....*....|....*....|....*.
gi 2462555497 1086 FEYCQLQSKVEDEQTLGLQFQKKIKE 1111
Cdd:pfam02029  295 EEEQRRKQEEAERKLREEEEKRRMKE 320
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
872-1097 2.16e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 42.99  E-value: 2.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  872 KELEEKLVTLVQEKNDLQ---LQVQAESENLLDAEERcdqLIKAKFQLEaKIKEVteraedeeeINAELTAKKRKLEDEC 948
Cdd:PRK05771    15 KSYKDEVLEALHELGVVHiedLKEELSNERLRKLRSL---LTKLSEALD-KLRSY---------LPKLNPLREEKKKVSV 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  949 SELKKDIDDLELTLAKVEKEkhatenkVKNLTEELSGLDETIAKLTREKKALQ--EAHQQALDDLQAEED---KVNSLNK 1023
Cdd:PRK05771    82 KSLEELIKDVEEELEKIEKE-------IKELEEEISELENEIKELEQEIERLEpwGNFDLDLSLLLGFKYvsvFVGTVPE 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1024 TK-SKLEQQVEDLESSLEQEKKLR-----VDLERNKRKLEGDLKLAQESILDLENDKqQLDERLKKKDFEYCQLQSKVED 1097
Cdd:PRK05771   155 DKlEELKLESDVENVEYISTDKGYvyvvvVVLKELSDEVEEELKKLGFERLELEEEG-TPSELIREIKEELEEIEKERES 233
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
839-1003 2.17e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.00  E-value: 2.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  839 PLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEA 918
Cdd:COG1196    660 GSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLE 739
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  919 KIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE---LT----LAKVEKEKHATENKVKNLTEELSGLDETIA 991
Cdd:COG1196    740 ELLEEEELLEEEALEELPEPPDLEELERELERLEREIEALGpvnLLaieeYEELEERYDFLSEQREDLEEARETLEEAIE 819
                          170
                   ....*....|...
gi 2462555497  992 KLTREKK-ALQEA 1003
Cdd:COG1196    820 EIDRETReRFLET 832
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
844-1113 2.19e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.58  E-value: 2.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  844 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEV 923
Cdd:COG4372     27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESL 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  924 TERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEA 1003
Cdd:COG4372    107 QEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALD 186
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1004 HQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKK 1083
Cdd:COG4372    187 ELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELA 266
                          250       260       270
                   ....*....|....*....|....*....|
gi 2462555497 1084 KDFEYCQLQSKVEDEQTLGLQFQKKIKELQ 1113
Cdd:COG4372    267 ILVEKDTEEEELEIAALELEALEEAALELK 296
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
1341-1541 2.22e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 42.99  E-value: 2.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1341 CDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQ 1420
Cdd:PRK05771    38 EELSNERLRKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKVSVKSLEELIKDVEEELEKIEKEIKELEEEISELENEIK 117
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1421 RLQGEVEDLM------VDVERAN---SLAAALDKKQRNFDKVLaewKTKCEESQAELEASLKE--------SRSLSTELF 1483
Cdd:PRK05771   118 ELEQEIERLEpwgnfdLDLSLLLgfkYVSVFVGTVPEDKLEEL---KLESDVENVEYISTDKGyvyvvvvvLKELSDEVE 194
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462555497 1484 KL-----------------KNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELeksrKQIELEKADI 1541
Cdd:PRK05771   195 EElkklgferleleeegtpSELIREIKEELEEIEKERESLLEELKELAKKYLEELLALYEY----LEIELERAEA 265
Spc7 smart00787
Spc7 kinetochore protein; This domain is found in cell division proteins which are required ...
903-1044 2.62e-03

Spc7 kinetochore protein; This domain is found in cell division proteins which are required for kinetochore-spindle association.


Pssm-ID: 197874 [Multi-domain]  Cd Length: 312  Bit Score: 41.93  E-value: 2.62e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497   903 EERCDQLIKAKFQLEAKIKEVTEraeDEEEINAELTakkrkledECSELKKDIDDLELTL-AKVEKEKHATENKVKNLTE 981
Cdd:smart00787  136 EWRMKLLEGLKEGLDENLEGLKE---DYKLLMKELE--------LLNSIKPKLRDRKDALeEELRQLKQLEDELEDCDPT 204
                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462555497   982 ELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKK 1044
Cdd:smart00787  205 ELDRAKEKLKKLLQEIMIKVKKLEELEEELQELESKIEDLTNKKSELNTEIAEAEKKLEQCRG 267
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
872-1224 2.76e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.20  E-value: 2.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  872 KELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 951
Cdd:COG4372      6 EKVGKARLSLFGLRPKTGILIAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEEL 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  952 KKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQ 1031
Cdd:COG4372     86 NEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEE 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1032 VEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKE 1111
Cdd:COG4372    166 LAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELE 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1112 LQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVA 1191
Cdd:COG4372    246 EDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELA 325
                          330       340       350
                   ....*....|....*....|....*....|...
gi 2462555497 1192 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1224
Cdd:COG4372    326 KKLELALAILLAELADLLQLLLVGLLDNDVLEL 358
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1315-1474 2.96e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.45  E-value: 2.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1315 ELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKyetdaiqrteeLEEAKKKL 1394
Cdd:COG1579     14 ELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEAR-----------IKKYEEQL 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1395 AQrlQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKE 1474
Cdd:COG1579     83 GN--VRNNKEYEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEE 160
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
1570-1916 3.12e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 42.65  E-value: 3.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1570 KSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRsvqg 1649
Cdd:pfam02463  155 RLEIEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLD---- 230
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1650 QLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKK 1729
Cdd:pfam02463  231 YLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKV 310
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1730 KLETDLMQLQSEVEDASRDARNA----EEKAKKAITDAAMMAEELKKEQDTSAhLERMKKNLEQTVKDLQHRLDEAEQLA 1805
Cdd:pfam02463  311 DDEEKLKESEKEKKKAEKELKKEkeeiEELEKELKELEIKREAEEEEEEELEK-LQEKLEQLEEELLAKKKLESERLSSA 389
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1806 LKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEE 1885
Cdd:pfam02463  390 AKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKK 469
                          330       340       350
                   ....*....|....*....|....*....|.
gi 2462555497 1886 adEQANAHLTKFRKAQHELEEAEERADIAES 1916
Cdd:pfam02463  470 --SEDLLKETQLVKLQEQLELLLSRQKLEER 498
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
848-1044 3.42e-03

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 41.17  E-value: 3.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  848 KEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQ--------------AESENLLDAEERCDQLIKAK 913
Cdd:pfam00261    1 KKMQQIKEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNRRIQlleeelerteerlaEALEKLEEAEKAADESERGR 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  914 FQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKL 993
Cdd:pfam00261   81 KVLENRALKDEEKMEILEAQLKEAKEIAEEADRKYEEVARKLVVVEGDLERAEERAELAESKIVELEEELKVVGNNLKSL 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462555497  994 -TREKKALQ------EAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKK 1044
Cdd:pfam00261  161 eASEEKASEredkyeEQIRFLTEKLKEAETRAEFAERSVQKLEKEVDRLEDELEAEKE 218
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
981-1085 3.56e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 42.38  E-value: 3.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  981 EELSGLDETIAKLTREKKAL----QEAHQQALDDLQAEEDKvnslnktkskLEQQVEDLESSLEQEKKLRVDLERNKRKL 1056
Cdd:COG0542    411 EELDELERRLEQLEIEKEALkkeqDEASFERLAELRDELAE----------LEEELEALKARWEAEKELIEEIQELKEEL 480
                           90       100
                   ....*....|....*....|....*....
gi 2462555497 1057 EGDlklaQESILDLENDKQQLDERLKKKD 1085
Cdd:COG0542    481 EQR----YGKIPELEKELAELEEELAELA 505
ATG14 pfam10186
Vacuolar sorting 38 and autophagy-related subunit 14; The Atg14 or Apg14 proteins are ...
863-999 3.65e-03

Vacuolar sorting 38 and autophagy-related subunit 14; The Atg14 or Apg14 proteins are hydrophilic proteins with a predicted molecular mass of 40.5 kDa, and have a coiled-coil motif at the N terminus region. Yeast cells with mutant Atg14 are defective not only in autophagy but also in sorting of carboxypeptidase Y (CPY), a vacuolar-soluble hydrolase, to the vacuole. Subcellular fractionation indicate that Apg14p and Apg6p are peripherally associated with a membrane structure(s). Apg14p was co-immunoprecipitated with Apg6p, suggesting that they form a stable protein complex. These results imply that Apg6/Vps30p has two distinct functions: in the autophagic process and in the vacuolar protein sorting pathway. Apg14p may be a component specifically required for the function of Apg6/Vps30p through the autophagic pathway. There are 17 auto-phagosomal component proteins which are categorized into six functional units, one of which is the AS-PI3K complex (Vps30/Atg6 and Atg14). The AS-PI3K complex and the Atg2-Atg18 complex are essential for nucleation, and the specific function of the AS-PI3K apparently is to produce phosphatidylinositol 3-phosphate (PtdIns(3)P) at the pre-autophagosomal structure (PAS). The localization of this complex at the PAS is controlled by Atg14. Autophagy mediates the cellular response to nutrient deprivation, protein aggregation, and pathogen invasion in humans, and malfunction of autophagy has been implicated in multiple human diseases including cancer. This effect seems to be mediated through direct interaction of the human Atg14 with Beclin 1 in the human phosphatidylinositol 3-kinase class III complex.


Pssm-ID: 462986 [Multi-domain]  Cd Length: 347  Bit Score: 41.67  E-value: 3.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  863 ELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE-RCDQLIkakfqLEAKIKEVTERAEdeeEINAELTAKK 941
Cdd:pfam10186   27 DLARLLSEKDSLKKKVEEALEGKEEGEQLEDNIGNKKLKLRLlKSEVAI-----SNERLNEIKDKLD---QLRREIAEKK 98
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462555497  942 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKA 999
Cdd:pfam10186   99 KKIEKLRSSLKQRRSDLESASYQLEERRASQLAKLQNSIKRIKQKWTALHSKTAESRS 156
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
954-1056 3.71e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 42.38  E-value: 3.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  954 DIDDLELTLAKVEKEKHATENkvknltEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVE 1033
Cdd:COG0542    412 ELDELERRLEQLEIEKEALKK------EQDEASFERLAELRDELAELEEELEALKARWEAEKELIEEIQELKEELEQRYG 485
                           90       100
                   ....*....|....*....|...
gi 2462555497 1034 DLESSLEQEKKLRVDLERNKRKL 1056
Cdd:COG0542    486 KIPELEKELAELEEELAELAPLL 508
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
949-1267 3.80e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.81  E-value: 3.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  949 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKL 1028
Cdd:COG4372     27 AALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESL 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1029 EQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKK 1108
Cdd:COG4372    107 QEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALD 186
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1109 IKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEA 1188
Cdd:COG4372    187 ELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELA 266
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462555497 1189 MVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEI 1267
Cdd:COG4372    267 ILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQL 345
CusB_dom_1 pfam00529
Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli ...
1251-1402 3.84e-03

Cation efflux system protein CusB domain 1; The cation efflux system protein CusB from E. coli can be divided into four different domains, the first three domains of the protein are mostly beta-strands and the fourth forms an all alpha-helical domain. This entry represents the first beta-domain (domain 1) of CusB and it is formed by the N and C-terminal ends of the polypeptide (residues 89-102 and 324-385). CusB is part of the copper-transporting efflux system CusCFBA. This domain can also be found in other membrane-fusion proteins, such as HlyD, MdtN, MdtE and AaeA. HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 41.64  E-value: 3.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1251 RTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNaL 1330
Cdd:pfam00529   54 TDYQAALDSAEAQLAKAQAQVARLQAELDRLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLARRRV-L 132
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462555497 1331 AHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKY----ETDAIQRTEELEEAKKKLAQRLQDSE 1402
Cdd:pfam00529  133 APIGGISRESLVTAGALVAQAQANLLATVAQLDQIYVQITQSAAENqaevRSELSGAQLQIAEAEAELKLAKLDLE 208
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
1202-1338 3.84e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.06  E-value: 3.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1202 AELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARgKNEEIQRSLSELTTQKSRL 1281
Cdd:COG1579     27 KELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVR-NNKEYEALQKEIESLKRRI 105
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1282 QT---EAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSR 1338
Cdd:COG1579    106 SDledEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAER 165
EcCorA_ZntB-like cd12821
Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily ...
1296-1408 4.03e-03

Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this family are found in all three kingdoms of life. It is a functionally diverse family, including the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), and the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). It also includes two Saccharomyces cerevisiae members: the inner membrane Mg2+ transporters Mfm1p/Lpe10p, and Mrs2p, and a family of Arabidopsis thaliana members (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213355 [Multi-domain]  Cd Length: 285  Bit Score: 41.53  E-value: 4.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1296 ESIVSQLSRSKQAFTQQTEELKRQLEEENKAKnALAHALqSSRHDCDLLREQYEEEQEGKAELQRALSKANSEvaQWRTK 1375
Cdd:cd12821    110 GAIIKALLTGIDQFEEKLEELEWDLLEGNNAI-KLDRIL-ELRRELLRLTNLIEPQQEVLMALQEAFAELLFS--EDEEE 185
                           90       100       110
                   ....*....|....*....|....*....|...
gi 2462555497 1376 YEtDAIQRTEELEEAKKKLAQRLQDSEEQVEAV 1408
Cdd:cd12821    186 LR-RTLDRIERLLQLIEEYEQELDTLQDIEEVV 217
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
831-1002 4.18e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 41.34  E-value: 4.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  831 MKLFFKIKPLLKSAETEKEMATMKeeFQKTKDELAKSEAKRKELEEKLVTLVQEKNDlqlqVQAESENLLDAEERCDQLI 910
Cdd:pfam15905  162 MKLRNKLEAKMKEVMAKQEGMEGK--LQVTQKNLEHSKGKVAQLEEKLVSTEKEKIE----EKSETEKLLEYITELSCVS 235
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  911 KakfQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL--ELTLAKVEKEKHATENKVK--NLTEELSGL 986
Cdd:pfam15905  236 E---QVEKYKLDIAQLEELLKEKNDEIESLKQSLEEKEQELSKQIKDLneKCKLLESEKEELLREYEEKeqTLNAELEEL 312
                          170
                   ....*....|....*.
gi 2462555497  987 DETIAKLTREKKALQE 1002
Cdd:pfam15905  313 KEKLTLEEQEHQKLQQ 328
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
844-982 4.62e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.06  E-value: 4.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  844 AETEKEMATMKEEFQKTKDELAKSE---------AKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKF 914
Cdd:COG4717     98 EELEEELEELEAELEELREELEKLEkllqllplyQELEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQE 177
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462555497  915 QLEAKIKEVTERAEDEEEinaELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 982
Cdd:COG4717    178 ELEELLEQLSLATEEELQ---DLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALE 242
Rabaptin pfam03528
Rabaptin;
1338-1620 4.93e-03

Rabaptin;


Pssm-ID: 367545 [Multi-domain]  Cd Length: 486  Bit Score: 41.63  E-value: 4.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1338 RHDCDLLREQYEEEQEgKAELQRALSKANSEVAQWRTKYETDAIQRTEEL-------EEAKKKLAQ---RLQDSEEQVEA 1407
Cdd:pfam03528    1 QPDEDLQQRVAELEKE-NAEFYRLKQQLEAEFNQKRAKFKELYLAKEEDLkrqnavlQEAQVELDAlqnQLALARAEMEN 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1408 VNAKCASLEKTKQRLQGEVEDLMVdvERANSLAAALDKKQRNF--------DKVLAEWKTKCEESQAELeASLKESRSLS 1479
Cdd:pfam03528   80 IKAVATVSENTKQEAIDEVKSQWQ--EEVASLQAIMKETVREYevqfhrrlEQERAQWNQYRESAEREI-ADLRRRLSEG 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1480 TELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQ-----IELEKAdiqlaleeaEAALEH 1554
Cdd:pfam03528  157 QEEENLEDEMKKAQEDAEKLRSVVMPMEKEIAALKAKLTEAEDKIKELEASKMKelnhyLEAEKS---------CRTDLE 227
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462555497 1555 EEAKILRIQLELTQVKSEIDRK-IAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKME 1620
Cdd:pfam03528  228 MYVAVLNTQKSVLQEDAEKLRKeLHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRME 294
growth_prot_Scy NF041483
polarized growth protein Scy;
1244-1926 5.09e-03

polarized growth protein Scy;


Pssm-ID: 469371 [Multi-domain]  Cd Length: 1293  Bit Score: 42.12  E-value: 5.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1244 ANLEKICRTLEDQLSEA--------RGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKqafTQQTEE 1315
Cdd:NF041483   364 AQLAKAARTAEEVLTKAsedakattRAAAEEAERIRREAEAEADRLRGEAADQAEQLKGAAKDDTKEYRAK---TVELQE 440
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1316 LKRQLEEENKAKNALAHAlQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQ-RTEELEEA---K 1391
Cdd:NF041483   441 EARRLRGEAEQLRAEAVA-EGERIRGEARREAVQQIEEAARTAEELLTKAKADADELRSTATAESERvRTEAIERAttlR 519
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1392 KKLAQRLQDSEEQVEAVNAKCASL-EKTKQRLQGEVEDLMVDVERanslaaALDKKQRNFDKVLAEWKTKCEESQAELEA 1470
Cdd:NF041483   520 RQAEETLERTRAEAERLRAEAEEQaEEVRAAAERAARELREETER------AIAARQAEAAEELTRLHTEAEERLTAAEE 593
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1471 SLKESRSLSTELFKlknayeEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQ---LALEE 1547
Cdd:NF041483   594 ALADARAEAERIRR------EAAEETERLRTEAAERIRTLQAQAEQEAERLRTEAAADASAARAEGENVAVRlrsEAAAE 667
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1548 AEAALEHEEAKILRIQLELT----QVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAE-VRSRNEAIRL----KKK 1618
Cdd:NF041483   668 AERLKSEAQESADRVRAEAAaaaeRVGTEAAEALAAAQEEAARRRREAEETLGSARAEADQErERAREQSEELlasaRKR 747
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1619 MEGDLNEIEIQLSHANRQAAETL----KHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAivERRANLLQAEVEELRA--- 1691
Cdd:NF041483   748 VEEAQAEAQRLVEEADRRATELVsaaeQTAQQVRDSVAGLQEQAEEEIAGLRSAAEHAA--ERTRTEAQEEADRVRSday 825
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1692 ----------------TLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLmqLQSEVEDASRDARNAEEK 1755
Cdd:NF041483   826 aererasedanrlrreAQEETEAAKALAERTVSEAIAEAERLRSDASEYAQRVRTEASDT--LASAEQDAARTRADARED 903
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1756 AKKAITDAAMMAEELKKEQDTSAHLERmkknlEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNT 1835
Cdd:NF041483   904 ANRIRSDAAAQADRLIGEATSEAERLT-----AEARAEAERLRDEARAEAERVRADAAAQAEQLIAEATGEAERLRAEAA 978
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1836 ESVKG-------LRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEAdEQANAHLTKFRKAQHEL---- 1904
Cdd:NF041483   979 ETVGSaqqhaerIRTEAERVKAEAAAEAERLRTEAREEADRTLDEARKDANKRRSEAA-EQADTLITEAAAEADQLtaka 1057
                          730       740
                   ....*....|....*....|...
gi 2462555497 1905 -EEAEERADIAESQVNKLRAKTR 1926
Cdd:NF041483  1058 qEEALRTTTEAEAQADTMVGAAR 1080
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
1174-1427 5.58e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 40.95  E-value: 5.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1174 KLRRDLEEATLQHEamvatLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDlsssmesvsksKANLEKICRTL 1253
Cdd:pfam15905   64 KSQKNLKESKDQKE-----LEKEIRALVQERGEQDKRLQALEEELEKVEAKLNAAVRE-----------KTSLSASVASL 127
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1254 EDQLSEARGKNEEIQRSLSELTTQKsRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHA 1333
Cdd:pfam15905  128 EKQLLELTRVNELLKAKFSEDGTQK-KMSSLSMELMKLRNKLEAKMKEVMAKQEGMEGKLQVTQKNLEHSKGKVAQLEEK 206
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1334 LQSSRHDCDLLREQYEEEQEGKAELQ---RALSKANSEVAQwrtkYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNA 1410
Cdd:pfam15905  207 LVSTEKEKIEEKSETEKLLEYITELScvsEQVEKYKLDIAQ----LEELLKEKNDEIESLKQSLEEKEQELSKQIKDLNE 282
                          250
                   ....*....|....*..
gi 2462555497 1411 KCASLEKTKQRLQGEVE 1427
Cdd:pfam15905  283 KCKLLESEKEELLREYE 299
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
1464-1707 5.79e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.35  E-value: 5.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1464 SQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKsrkqielekadiql 1543
Cdd:COG3883     14 ADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEA-------------- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1544 aleeaeaaleheeakilriqleltqvkseidrKIAEKDEEIEQLKRNYQRTVETMqSALDAEVRSRNeairlkkkmEGDL 1623
Cdd:COG3883     80 --------------------------------EIEERREELGERARALYRSGGSV-SYLDVLLGSES---------FSDF 117
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1624 NEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLA 1703
Cdd:COG3883    118 LDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQ 197

                   ....
gi 2462555497 1704 EQEL 1707
Cdd:COG3883    198 LAEL 201
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
1328-1533 6.53e-03

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 40.90  E-value: 6.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1328 NALAHALQSSRHDCDLLREQyeeeqegkaelqraLSKANSEVAQWRTKYETDAIQRTEELEEAKkklaQRLQDSEEQVEA 1407
Cdd:pfam09787   43 TALTLELEELRQERDLLREE--------------IQKLRGQIQQLRTELQELEAQQQEEAESSR----EQLQELEEQLAT 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1408 VNAKCASLEKTKQRLQGEVEDLMVDVERA-NSLAAALDKKQRNFDKVLAEWKTKC--EESQAELEASLKE-SRSL---ST 1480
Cdd:pfam09787  105 ERSARREAEAELERLQEELRYLEEELRRSkATLQSRIKDREAEIEKLRNQLTSKSqsSSSQSELENRLHQlTETLiqkQT 184
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462555497 1481 ELFKLKNAYEEALDQLETVKRENKNLEQEIADlteQIAENGKTIHELEKSRKQ 1533
Cdd:pfam09787  185 MLEALSTEKNSLVLQLERMEQQIKELQGEGSN---GTSINMEGISDGEGTRLR 234
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1048-1852 7.25e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 41.25  E-value: 7.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1048 DLERNKRKLEGDLKLAQESILDL-----ENDKQQLDERLKKKDFE--------YCQLQSKVEDEQTLGLQFQKKIKELQA 1114
Cdd:pfam05483   27 NLSKNGENIDSDPAFQKLNFLPMleqvaNSGDCHYQEGLKDSDFEnseglsrlYSKLYKEAEKIKKWKVSIEAELKQKEN 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1115 RIEELEEEIEAERATRAKTE--------------KQRSDYARELEELSERLEEAGGVTSTQIELNKKREAE-------FL 1173
Cdd:pfam05483  107 KLQENRKIIEAQRKAIQELQfenekvslkleeeiQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEreetrqvYM 186
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1174 KLRRDLEEATLQHEAMVATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTL 1253
Cdd:pfam05483  187 DLNNNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEES 266
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1254 EDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGE----LSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNA 1329
Cdd:pfam05483  267 RDKANQLEEKTKLQDENLKELIEKKDHLTKELEDikmsLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAA 346
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1330 LAHALQSSRHDCDLLREQYEEEQegkaelqralskansevaqwrtkyetdaiQRTEELEEAKKKLAQRLQDSEEQVEavn 1409
Cdd:pfam05483  347 HSFVVTEFEATTCSLEELLRTEQ-----------------------------QRLEKNEDQLKIITMELQKKSSELE--- 394
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1410 akcaSLEKTKQRLQGEVEDLMVDVERANSLaaaLDKKQRnFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAY 1489
Cdd:pfam05483  395 ----EMTKFKNNKEVELEELKKILAEDEKL---LDEKKQ-FEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSE 466
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1490 EEALDQLETVKREnknLEQEIADLTEQIAENGKTIHEleksrkqielekadiqlaleeaeaaleheeakilriQLELTQV 1569
Cdd:pfam05483  467 EHYLKEVEDLKTE---LEKEKLKNIELTAHCDKLLLE------------------------------------NKELTQE 507
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1570 KSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQG 1649
Cdd:pfam05483  508 ASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEK 587
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1650 QLKdtqlhlddalrgqedlkeqlaIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQ----NTSLI 1725
Cdd:pfam05483  588 QMK---------------------ILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKvnklELELA 646
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1726 HTKKKLETDLMQLQSEVEDASRDARN---AEEKAKKAITDAAMMAEELKK--EQDTSAHLERMKKNLEQTVKDLQHRLDE 1800
Cdd:pfam05483  647 SAKQKFEEIIDNYQKEIEDKKISEEKlleEVEKAKAIADEAVKLQKEIDKrcQHKIAEMVALMEKHKHQYDKIIEERDSE 726
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462555497 1801 aeqLALKGGKKQIQK-----LETRIRELEFELEGEQKKNTESVKGLRKYERRVKELT 1852
Cdd:pfam05483  727 ---LGLYKNKEQEQSsakaaLEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENT 780
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
982-1136 7.35e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 40.29  E-value: 7.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  982 ELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLE--QEKKLRVDLERNKRKLEGD 1059
Cdd:COG1579     18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKkyEEQLGNVRNNKEYEALQKE 97
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462555497 1060 LKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTlglQFQKKIKELQARIEELEEEIEAERATRAKTEKQ 1136
Cdd:COG1579     98 IESLKRRISDLEDEILELMERIEELEEELAELEAELAELEA---ELEEKKAELDEELAELEAELEELEAEREELAAK 171
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
1174-1406 8.45e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 41.19  E-value: 8.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1174 KLRRDLEEATlqheamvATLRKKHADSVAELGEQIDNLQRVKQKLEKEKsEFKLEIDDLsssmesvskskanlEKICRTL 1253
Cdd:PRK10929    27 QITQELEQAK-------AAKTPAQAEIVEALQSALNWLEERKGSLERAK-QYQQVIDNF--------------PKLSAEL 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1254 EDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG--ELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE--------- 1322
Cdd:PRK10929    85 RQQLNNERDEPRSVPPNMSTDALEQEILQVSSQllEKSRQAQQEQDRAREISDSLSQLPQQQTEARRQLNEierrlqtlg 164
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1323 -----ENKAKNALAHALQSSRHdcdLLREQYEEEQEgKAELQRALSKANSEVAQWRTKyETDAiqrteELEEAKKKL-AQ 1396
Cdd:PRK10929   165 tpntpLAQAQLTALQAESAALK---ALVDELELAQL-SANNRQELARLRSELAKKRSQ-QLDA-----YLQALRNQLnSQ 234
                          250
                   ....*....|
gi 2462555497 1397 RLQDSEEQVE 1406
Cdd:PRK10929   235 RQREAERALE 244
BAR_SNX7_30 cd07624
The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 7 and 30; BAR domains are dimerization, ...
956-1063 8.50e-03

The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins 7 and 30; BAR domains are dimerization, lipid binding and curvature sensing modules found in many different proteins with diverse functions. Sorting nexins (SNXs) are Phox homology (PX) domain containing proteins that are involved in regulating membrane traffic and protein sorting in the endosomal system. SNXs differ from each other in their lipid-binding specificity, subcellular localization and specific function in the endocytic pathway. A subset of SNXs also contain BAR domains. The PX-BAR structural unit determines the specific membrane targeting of SNXs. This subfamily consists of SNX7, SNX30, and similar proteins. The specific functions of SNX7 and SNX30 have not been elucidated. BAR domains form dimers that bind to membranes, induce membrane bending and curvature, and may also be involved in protein-protein interactions.


Pssm-ID: 153308  Cd Length: 200  Bit Score: 39.67  E-value: 8.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  956 DDLELTLAKVEKEKHATENKVKNLTEELsgldetiAKLTREKKALQEAHQQAL---DDLQAE-EDKVNSLNKTKSKLEQQ 1031
Cdd:cd07624     70 PLLEGVSSAVERCTAALEVLLSDHEFVF-------LPPLREYLLYSDAVKDVLkrrDQFQIEyELSVEELNKKRLELLKE 142
                           90       100       110
                   ....*....|....*....|....*....|...
gi 2462555497 1032 VEDLESSLE-QEKKLRVDLERNKRKLEGDLKLA 1063
Cdd:cd07624    143 VEKLQDKLEcANADLKADLERWKQNKRQDLKKI 175
PRK10361 PRK10361
DNA recombination protein RmuC; Provisional
925-1108 8.79e-03

DNA recombination protein RmuC; Provisional


Pssm-ID: 182409 [Multi-domain]  Cd Length: 475  Bit Score: 40.74  E-value: 8.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  925 ERAEDEEEINAELTAKKRKL------EDECSELKkdiddleltlakvekekhateNKVKNLTEELSGLDETIAKLTREKK 998
Cdd:PRK10361    33 EQLAEREEMVAELSAAKQQItqsehwRAECELLN---------------------NEVRSLQSINTSLEADLREVTTRME 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  999 ALQeahqqalddlQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDlERNKRKLEGDLKLAQESildLENDKQQLD 1078
Cdd:PRK10361    92 AAQ----------QHADDKIRQMINSEQRLSEQFENLANRIFEHSNRRVD-EQNRQSLNSLLSPLREQ---LDGFRRQVQ 157
                          170       180       190
                   ....*....|....*....|....*....|
gi 2462555497 1079 ERLKKKDFEYCQLQSKVEDEQTLGLQFQKK 1108
Cdd:PRK10361   158 DSFGKEAQERHTLAHEIRNLQQLNAQMAQE 187
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
857-1113 8.84e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 40.99  E-value: 8.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  857 FQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIK-----------AKFQLEAKIKEVTE 925
Cdd:pfam06160   81 FKKAKKALDEIEELLDDIEEDIKQILEELDELLESEEKNREEVEELKDKYRELRKtllanrfsygpAIDELEKQLAEIEE 160
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  926 R---------------AEDE-EEINAELTAKKRKLED------ECS-ELKKDIDDLELTLAKVEKEKHA-----TENKVK 977
Cdd:pfam06160  161 EfsqfeeltesgdyleAREVlEKLEEETDALEELMEDipplyeELKtELPDQLEELKEGYREMEEEGYAlehlnVDKEIQ 240
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497  978 NLTEELSGLDETIAKLTREK-----KALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLEsslEQEKKLRVDLER- 1051
Cdd:pfam06160  241 QLEEQLEENLALLENLELDEaeealEEIEERIDQLYDLLEKEVDAKKYVEKNLPEIEDYLEHAE---EQNKELKEELERv 317
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462555497 1052 ------NKRKLEgDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQ 1113
Cdd:pfam06160  318 qqsytlNENELE-RVRGLEKQLEELEKRYDEIVERLEEKEVAYSELQEELEEILEQLEEIEEEQEEFK 384
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
1683-1910 8.91e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 40.88  E-value: 8.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1683 QAEVEELRATLEQTERarKLAEQELLDSNERVQLLHTQNTSlihtKKKLETDLMQLQsEVEDASRDARNAEEKAKKAITD 1762
Cdd:pfam05557    1 RAELIESKARLSQLQN--EKKQMELEHKRARIELEKKASAL----KRQLDRESDRNQ-ELQKRIRLLEKREAEAEEALRE 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462555497 1763 AAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL-DEAEQLalkggKKQIQKLETRIRELEFELEGEQKKNTESVKGL 1841
Cdd:pfam05557   74 QAELNRLKKKYLEALNKKLNEKESQLADAREVISCLkNELSEL-----RRQIQRAELELQSTNSELEELQERLDLLKAKA 148
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462555497 1842 RKYERRVKELTYQSEEDRKNVLRLQDLVDKLQvkvkSYKRQAEEAdEQANAHLTKFRKAQHELEEAEER 1910
Cdd:pfam05557  149 SEAEQLRQNLEKQQSSLAEAEQRIKELEFEIQ----SQEQDSEIV-KNSKSELARIPELEKELERLREH 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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