N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733   1 MRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVS 80
Cdd:cd07886    14 MRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGLKEVTVTVCLVWKDPPHRVHPHGLVGKDCPNGICQVTLNPHSS 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462566733  81 PRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGQMRRMDPVLSEPVYDKK 159
Cdd:cd07886    94 PRHSFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKNHEEVDMNVVRLCFQASYRDDDGRKDCLSPVLSEPIYDKK 172

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733 167 RICRINKESGPCTGGEELYLLCDKVQKEDISVVFS-----RASWEGRADFSQADVHRQIAIVFKTPPYEDLEIVEPVTVN 241
Cdd:pfam16179   1 KICRLSLCSGSVTGGEEIILLCEKVLKDDIKVRFYeeddgQEVWEAEGDFSKTDVHRQVAIVFKTPPYRDPDITEPVTVN 80

                          90       100
                  ....*....|....*....|..
gi 2462566733 242 VFLQRLTDGVCSEPLPFTYLPR 263
Cdd:pfam16179  81 IQLRRPSDKATSEPQPFTYLPL 102

N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733   1 MRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVS 80
Cdd:cd07886    14 MRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGLKEVTVTVCLVWKDPPHRVHPHGLVGKDCPNGICQVTLNPHSS 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462566733  81 PRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGQMRRMDPVLSEPVYDKK 159
Cdd:cd07886    94 PRHSFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKNHEEVDMNVVRLCFQASYRDDDGRKDCLSPVLSEPIYDKK 172

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733   1 MRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGlrEVEVTACLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHvS 80
Cdd:pfam00554  12 MRFRYKCEGRSAGSIPGESSTRSKKTFPTVQICNYDG--PAVIRVSLVTKDEPHRPHPHSLVGKDCKDGVCEVELGPE-D 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733  81 PRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYN--AGSLKNHQEVDMNVVRICFQASYRDQQGQ-MRRMDPVLSEPVYD 157
Cdd:pfam00554  89 MVASFQNLGIQCVKKKDVEEALKERIELNIDPFNvgFEALRQIKDMDLNVVRLCFQAFLPDTRGNfTTPLPPVVSNPIYD 168

                  .
gi 2462566733 158 K 158
Cdd:pfam00554 169 K 169

IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733 166 LRICRINKESGPCTGGEELYLLCDKVQKEDISVVF-----SRASWEGRADFSQADVHRQIAIVFKTPPYEDLEIVEPVTV 240
Cdd:cd01177     1 LKICRLDKTSGSVKGGDEVYLLCDKVQKEDIQVRFfeedeEETVWEAFGDFSQTDVHRQYAIVFRTPPYHDPDITEPVKV 80

                          90       100
                  ....*....|....*....|..
gi 2462566733 241 NVFLQRLTDGVCSEPLPFTYLP 262
Cdd:cd01177    81 KIQLKRPSDGERSESVPFTYVP 102

N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733   1 MRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVS 80
Cdd:cd07886    14 MRFRYECEGRSAGSILGESSTEANKTQPAIEIQNCIGLKEVTVTVCLVWKDPPHRVHPHGLVGKDCPNGICQVTLNPHSS 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462566733  81 PRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGQMRRMDPVLSEPVYDKK 159
Cdd:cd07886    94 PRHSFSNLGIQCVRKREIEAAIETRLQLNIDPFKAGSLKNHEEVDMNVVRLCFQASYRDDDGRKDCLSPVLSEPIYDKK 172

N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal sub-domain, which may be distantly related to the DNA-binding domain found in P53. The C-terminal sub-domain has an immunoglobulin-like fold and serves as a dimerization module that also binds DNA (see cd00102). The RHD is found in NF-kappa B, nuclear factor of activated T-cells (NFAT), the tonicity-responsive enhancer binding protein (TonEBP), and the arthropod proteins Dorsal and Relish (Rel).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733   1 MRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGlrEVEVTACLVWKDWPHRVHPHSLVGK-DCTDGICRVRLRPHV 79
Cdd:cd07827    14 HRFRYECEGRSAGSIPGENSTADRKTFPTVKLRNYNG--PAKIVVSLVTKDDPPKPHPHQLVGKtDCRDGVCEVRLGPKN 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733  80 SPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPY--NAGSLKNHQEVDMNVVRICFQASYRDQQGQMR-RMDPVLSEPVY 156
Cdd:cd07827    92 NMTASFNNLGIQCVRKKDVEEALGQRIQLGIDPFmvHKGPEGNASDIDLNRVRLCFQAFIEDSDGGFTlPLPPVLSNPIY 171

                  ...
gi 2462566733 157 DKK 159
Cdd:cd07827   172 DKK 174

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733 167 RICRINKESGPCTGGEELYLLCDKVQKEDISVVFS-----RASWEGRADFSQADVHRQIAIVFKTPPYEDLEIVEPVTVN 241
Cdd:pfam16179   1 KICRLSLCSGSVTGGEEIILLCEKVLKDDIKVRFYeeddgQEVWEAEGDFSKTDVHRQVAIVFKTPPYRDPDITEPVTVN 80

                          90       100
                  ....*....|....*....|..
gi 2462566733 242 VFLQRLTDGVCSEPLPFTYLPR 263
Cdd:pfam16179  81 IQLRRPSDKATSEPQPFTYLPL 102

N-terminal sub-domain of the Rel homology domain (RHD) of RelA; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD domain of the RelA family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelA (also called p65) forms heterodimers with NF-kappa B1 (p50) and B2 (p52). RelA also forms homodimers.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733   1 MRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTacLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVS 80
Cdd:cd07885    14 MRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINNYTGPGRVRIS--LVTKDPPHKPHPHELVGKDCKDGYYEAELSPDRC 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462566733  81 PrHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGQMRRMDPVLSEPVYDKK 159
Cdd:cd07885    92 I-HSFQNLGIQCVKKRDLEQAVSQRIQTNNNPFNVPIEEQRADYDLNAVRLCFQVTVRDPSGRLLPLPPVLSQPIYDNR 169

N-terminal sub-domain of the Rel homology domain (RHD) of c-Rel; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the c-Rel family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). c-Rel plays an important role in B cell proliferation and survival.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733   1 MRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTacLVWKDWPHRVHPHSLVGKDCTDGICRVRLRPHVS 80
Cdd:cd07933    14 MRFRYKCEGRSAGSIPGERSTDNNRTYPSIQILNYTGKGKVRIT--LVTKNEPYKPHPHDLVGKDCRDGYYEAEFGPERR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733  81 PRhSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAG--SLKNHQEVDMNVVRICFQASYRDQQGQMRRM-DPVLSEPVYD 157
Cdd:cd07933    92 VL-AFQNLGIQCVRRREVKEAIMLRISRGINPFNVPeeQLLQIEEYDLNVVRLCFQIFLPDEHGNYTTAlPPIVSNPIYD 170

                  ..
gi 2462566733 158 KK 159
Cdd:cd07933   171 NR 172

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa light polypeptide gene enhancer in B-cells (NF-kappa B); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NF-kappa B1 and B2 families of transcription factors, also referred to as class I members of the NF-kappa B family. In class I NF-kappa Bs, the RHD domain co-occurs with C-terminal ankyrin repeats. Family members include NF-kappa B1 and NF-kappa B2. NF-kappa B1 is commonly referred to as p105 or p50 (proteolytically processed form), while NF-kappa B2 is called p100 or p52 (proteolytically processed form). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and REL). p105 and p100 may also act as I-kappa Bs due to their C-terminal ankyrin repeats.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733   2 RFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTacLVWKDWPHRVHPHSLVGKDCTDGICRVRlrphVSP 81
Cdd:cd07883    15 RFRYGCEGPSHGGLPGASSEKNKKSYPTVKICNYQGPARIVVQ--LVTNSEPPRLHAHSLVGKHCEDGICTVQ----VGP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733  82 RH---SFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNH---------------------------QEVDMNVVRI 131
Cdd:cd07883    89 KDmtaQFPNLGILHVTKKNVVETLEARLLAQCTRGYNPGDLVHvdaegggdrqltdeeqaeirqkakqqaKSMDLSVVRL 168

                         170       180
                  ....*....|....*....|....*....
gi 2462566733 132 CFQASYRDQQGQM-RRMDPVLSEPVYDKK 159
Cdd:cd07883   169 CFQAFLPDSNGSFtRPLKPVISDAIYDSK 197

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NF-kappa B2 family of transcription factors, a class I member of the NF-kappa B family. In class I NF-kappa Bs, the RHD domain co-occurs with C-terminal ankyrin repeats. NF-kappa B2 is commonly referred to as p100 or p52 (proteolytically processed form). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and REL). NF-kappa B2 is involved in the alternative NF-kappa B signaling pathway which is activated by few agonists and plays an important role in secondary lymphoid organogenesis, maturation of B-cells, and adaptive humoral immunity. p100 may also act as an I-kappa B due to its C-terminal ankyrin repeats.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733   2 RFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTacLVWKDWPHRVHPHSLVGKDCTD-GICRVRLRPHvS 80
Cdd:cd07934    15 RFRYVCEGPSHGGLPGASSEKGRKTYPTVKICNYVGMARIEVD--LVTHTDPPRVHAHSLVGKHCNEsGNCSVDVGPK-D 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733  81 PRHSFNNLGIQCVRKKEIEAAIERKIQLGI----DPY---NAGSLKNHQEV-------DMNVVRICFQASYRDQQGQMRR 146
Cdd:cd07934    92 MTAQFSNLGILHVTKKNMMEILKEKLKRQKlrntGPYkltEAEERELEQEAkelkkvmDLSIVRLKFTAYLRDSNGSYTL 171

                         170
                  ....*....|....
gi 2462566733 147 -MDPVLSEPVYDKK 159
Cdd:cd07934   172 aLKPVISDPIHDSK 185

ig-like, plexins, transcription factors;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733  165 ELRICRINKESGPCTGGEELyLLCDKVQKEDISVVFSRASWEGRADFSQAdvhRQIAIVFKTPPYEDLEIVEPVTvNVFL 244
Cdd:smart00429   1 DPVITRISPTSGPVSGGTEI-TLCGKNLKSISVVFVEVGVGEAPCTFSPS---SSTAIVCKTPPYHNIPGSVPVR-TVGL 75

                           90
                   ....*....|....*..
gi 2462566733  245 QRltDGVCSEPLPFTYL 261
Cdd:smart00429  76 RN--GGVPSSPQPFTYV 90

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462566733 168 ICRINKESGPCTGGEELYLLCDKVQKeDISVVF------SRASWEGRADFSQADVHrQIAIVFKTPPYEDLEIVEPVTVN 241
Cdd:cd01178     4 IEKKSLNSCSVNGGEELFLTGKNFLK-DSKVVFqekgqdGEAQWEAEATIDKEKSH-QNHLVVEVPPYHNKHVAAPVQVQ 81

                          90       100
                  ....*....|....*....|....*..
gi 2462566733 242 VFlqrltdgVC------SEPLPFTYLP 262
Cdd:cd01178    82 FY-------VVngkrkrSQPQTFTYTP 101