NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462568506|ref|XP_054178509|]
View 

zinc finger protein 160 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
331-774 3.71e-17

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 85.13  E-value: 3.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 331 KPFKCNECGKLFTQNSHLISHWRIHTGEKPYKCN--ECGKAFSVRSSLAIHQTIHTGEKPYKCNECGKVFRYNSYlgrhr 408
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS----- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 409 rvhtgekPYKCNECGKAFSMHSNLATHQVIHTGTKPFKCNECSKVFTQNSQLANHRRIHTGEK-------PYKCNECGKA 481
Cdd:COG5048   107 -------SSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 482 FSVRSSLTTHQAIHSGEKPYKCIECGKSFTQKSHLRSHRGIHSGEKPYKCNECGKVFAQTSQlaRHWRVHTGEKPYKCND 561
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLL--SQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 562 CGRAFSDRSSLTFHQAIHTgekpykchecgkvfrhNSYLATHRRIHTgekPYKCNECGKAFSMHSNLTTHK--VIHTGE- 638
Cdd:COG5048   258 SESPRSSLPTASSQSSSPN----------------ESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 639 -KPYKC--NQCGKVFTQNSHLANHQRTHTGEKPYRC--NECGKAFSV----RSSLTTHQAIHTGKKPYKC---NECGKVF 706
Cdd:COG5048   319 lKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllnnEPPQSLQQYKDLKNDKKSEtlsNSCIRNF 398

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 707 TQNAHLANHRRIHTGEKPY--RCTECGKAFRVRSSLTTHMAIHTgEKRYKCNECGKVFRQSSNLASHHRM 774
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGKD 467
KRAB super family cl42959
krueppel associated box;
1-32 7.76e-06

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 43.74  E-value: 7.76e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462568506    1 MLENYWNLVSLGLCHFDMNIISMLEEGKEPWT 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-314 1.72e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.72e-03
                          10        20
                  ....*....|....*....|....
gi 2462568506 291 YLATHRRIHTGEKPYKCNECGKAF 314
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
235-259 1.74e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.74e-03
                          10        20
                  ....*....|....*....|....*
gi 2462568506 235 NLTSHRRIHSGEKPYKCSECGKTFT 259
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 180-296 1.78e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 180 SVSPLQQIPSSVQTHRSKKYHELNHFSLLTQRRKANSCGKPYKCN--ECGKAFTQNSNLTSHRrihsgekpyKCSECGKT 257
Cdd:COG5189   309 EMIDVRKLPCTNSSSNGKLAHGGERNIDTPSRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQK 379

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2462568506 258 FTVRSNLTIHQVIHTGEKPYKCHECGKVFRHNSYLATHR 296
Cdd:COG5189   380 LHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
331-774 3.71e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 85.13  E-value: 3.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 331 KPFKCNECGKLFTQNSHLISHWRIHTGEKPYKCN--ECGKAFSVRSSLAIHQTIHTGEKPYKCNECGKVFRYNSYlgrhr 408
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS----- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 409 rvhtgekPYKCNECGKAFSMHSNLATHQVIHTGTKPFKCNECSKVFTQNSQLANHRRIHTGEK-------PYKCNECGKA 481
Cdd:COG5048   107 -------SSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 482 FSVRSSLTTHQAIHSGEKPYKCIECGKSFTQKSHLRSHRGIHSGEKPYKCNECGKVFAQTSQlaRHWRVHTGEKPYKCND 561
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLL--SQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 562 CGRAFSDRSSLTFHQAIHTgekpykchecgkvfrhNSYLATHRRIHTgekPYKCNECGKAFSMHSNLTTHK--VIHTGE- 638
Cdd:COG5048   258 SESPRSSLPTASSQSSSPN----------------ESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 639 -KPYKC--NQCGKVFTQNSHLANHQRTHTGEKPYRC--NECGKAFSV----RSSLTTHQAIHTGKKPYKC---NECGKVF 706
Cdd:COG5048   319 lKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllnnEPPQSLQQYKDLKNDKKSEtlsNSCIRNF 398

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 707 TQNAHLANHRRIHTGEKPY--RCTECGKAFRVRSSLTTHMAIHTgEKRYKCNECGKVFRQSSNLASHHRM 774
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGKD 467
KRAB smart00349
krueppel associated box;
1-32 7.76e-06

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 43.74  E-value: 7.76e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462568506    1 MLENYWNLVSLGLCHFDMNIISMLEEGKEPWT 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
655-679 8.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.17e-04
                          10        20
                  ....*....|....*....|....*
gi 2462568506 655 HLANHQRTHTGEKPYRCNECGKAFS 679
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-314 1.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.72e-03
                          10        20
                  ....*....|....*....|....
gi 2462568506 291 YLATHRRIHTGEKPYKCNECGKAF 314
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
235-259 1.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.74e-03
                          10        20
                  ....*....|....*....|....*
gi 2462568506 235 NLTSHRRIHSGEKPYKCSECGKTFT 259
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 180-296 1.78e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 180 SVSPLQQIPSSVQTHRSKKYHELNHFSLLTQRRKANSCGKPYKCN--ECGKAFTQNSNLTSHRrihsgekpyKCSECGKT 257
Cdd:COG5189   309 EMIDVRKLPCTNSSSNGKLAHGGERNIDTPSRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQK 379

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2462568506 258 FTVRSNLTIHQVIHTGEKPYKCHECGKVFRHNSYLATHR 296
Cdd:COG5189   380 LHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 221-243 4.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.95e-03
                          10        20
                  ....*....|....*....|...
gi 2462568506 221 YKCNECGKAFTQNSNLTSHRRIH 243
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
331-774 3.71e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 85.13  E-value: 3.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 331 KPFKCNECGKLFTQNSHLISHWRIHTGEKPYKCN--ECGKAFSVRSSLAIHQTIHTGEKPYKCNECGKVFRYNSYlgrhr 408
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS----- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 409 rvhtgekPYKCNECGKAFSMHSNLATHQVIHTGTKPFKCNECSKVFTQNSQLANHRRIHTGEK-------PYKCNECGKA 481
Cdd:COG5048   107 -------SSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKD 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 482 FSVRSSLTTHQAIHSGEKPYKCIECGKSFTQKSHLRSHRGIHSGEKPYKCNECGKVFAQTSQlaRHWRVHTGEKPYKCND 561
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLL--SQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 562 CGRAFSDRSSLTFHQAIHTgekpykchecgkvfrhNSYLATHRRIHTgekPYKCNECGKAFSMHSNLTTHK--VIHTGE- 638
Cdd:COG5048   258 SESPRSSLPTASSQSSSPN----------------ESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLrsVNHSGEs 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 639 -KPYKC--NQCGKVFTQNSHLANHQRTHTGEKPYRC--NECGKAFSV----RSSLTTHQAIHTGKKPYKC---NECGKVF 706
Cdd:COG5048   319 lKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllnnEPPQSLQQYKDLKNDKKSEtlsNSCIRNF 398

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 707 TQNAHLANHRRIHTGEKPY--RCTECGKAFRVRSSLTTHMAIHTgEKRYKCNECGKVFRQSSNLASHHRM 774
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
219-659 1.10e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 80.51  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 219 KPYKCNECGKAFTQNSNLTSHRRIHSGEKPYKCS--ECGKTFTVRSNLTIHQVIHTGEKPYKChecgkvfRHNSYLATHR 296
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLN-------SKSLPLSNSK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 297 RIHtgekpYKCNECGKAFRGHSNLTTHQLIHTGEKPFKCNEcgklftqnsHLISHWRIHtgeKPYKCNECGKAFSVRSSL 376
Cdd:COG5048   105 ASS-----SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDL---------LSISNLRNN---PLPGNNSSSVNTPQSNSL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 377 -AIHQTIHTGEKPYKcnecgkvfryNSYLGRHRRVHTGEKPYKCNECGKAFSMHSNLATHQVIHTGTKPFKCNECSKVFT 455
Cdd:COG5048   168 hPPLPANSLSKDPSS----------NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 456 QNSQLANHRRIHTGEKPYKCNECGKAF--SVRSSLTTHQAIHSGE-----KPYKCIECGKSFTQKSHLRSHR--GIHSGE 526
Cdd:COG5048   238 KSLLSQSPSSLSSSDSSSSASESPRSSlpTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 527 --KPYKCNE--CGKVFAQTSQLARHWRVHTGEKPYKCNDCGRAFSDRSSLTF----HQAIHTGEKPYKCHEC-------G 591
Cdd:COG5048   318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDLKNDKKSETlsnscirN 397

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462568506 592 KVFRHNSYLATHRRIHTGEKPYKCNECGKAFSMHSNLTTHKVIHTGEKPYKCNQCGKvFTQNSHLANH 659
Cdd:COG5048   398 FKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
442-782 1.05e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 1.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 442 TKPFKCNECSKVFTQNSQLANHRRIHTGEKPYKCN--ECGKAFSVRSSLTTHQAIHSGEKPYKC-IECGKSFTQKSHLRS 518
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 519 HRGIHSGEKPYKCNECGKVFAQTSQLARHWRVHTGEKPYKCNDCGRAFSDRSSLTFHQAIHTGekpykcHECGKVFRHNS 598
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA------NSLSKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 599 YLATHRRIHTGEKPYKCNECGKAFSMHSNLTTHKVIHTGEKPYKCNQCGKVFT------QNSHLANHQRTHTGEKPYRCN 672
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPksllsqSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 673 ECGKAFSVRSSLTTHQAIHTGK-KPYKCNECGKVFTQNAHLANHRR--IHTGE--KPYRCTEcgkafrvrssltthmaih 747
Cdd:COG5048   265 LPTASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPY------------------ 326

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 2462568506 748 tgekrykcNECGKVFRQSSNLASHHRMHTGEKPYK 782
Cdd:COG5048   327 --------SLCGKLFSRNDALKRHILLHTSISPAK 353
KRAB smart00349
krueppel associated box;
1-32 7.76e-06

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 43.74  E-value: 7.76e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462568506    1 MLENYWNLVSLGLCHFDMNIISMLEEGKEPWT 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
655-679 8.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.17e-04
                          10        20
                  ....*....|....*....|....*
gi 2462568506 655 HLANHQRTHTGEKPYRCNECGKAFS 679
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
623-700 1.30e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 623 SMHSNLTTHKVIHTGEKPYKCNQCGKVFTQNSHLANHQRTHTGEKPYRCN--ECGKAFSVRSSLTTHQAIHTGKKPYKCN 700
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
599-623 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....*
gi 2462568506 599 YLATHRRIHTGEKPYKCNECGKAFS 623
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
711-734 1.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|....
gi 2462568506 711 HLANHRRIHTGEKPYRCTECGKAF 734
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-314 1.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.72e-03
                          10        20
                  ....*....|....*....|....
gi 2462568506 291 YLATHRRIHTGEKPYKCNECGKAF 314
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
235-259 1.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.74e-03
                          10        20
                  ....*....|....*....|....*
gi 2462568506 235 NLTSHRRIHSGEKPYKCSECGKTFT 259
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 180-296 1.78e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462568506 180 SVSPLQQIPSSVQTHRSKKYHELNHFSLLTQRRKANSCGKPYKCN--ECGKAFTQNSNLTSHRrihsgekpyKCSECGKT 257
Cdd:COG5189   309 EMIDVRKLPCTNSSSNGKLAHGGERNIDTPSRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQK 379

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2462568506 258 FTVRSNLTIHQVIHTGEKPYKCHECGKVFRHNSYLATHR 296
Cdd:COG5189   380 LHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
460-483 1.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.94e-03
                          10        20
                  ....*....|....*....|....
gi 2462568506 460 LANHRRIHTGEKPYKCNECGKAFS 483
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
487-512 2.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.76e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462568506 487 SLTTHQAIHSGEKPYKCIECGKSFTQ 512
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 641-663 3.00e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 3.00e-03
                          10        20
                  ....*....|....*....|...
gi 2462568506 641 YKCNQCGKVFTQNSHLANHQRTH 663
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
406-427 3.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.17e-03
                          10        20
                  ....*....|....*....|..
gi 2462568506 406 RHRRVHTGEKPYKCNECGKAFS 427
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
627-652 3.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462568506 627 NLTTHKVIHTGEKPYKCNQCGKVFTQ 652
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
739-764 4.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.34e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462568506 739 SLTTHMAIHTGEKRYKCNECGKVFRQ 764
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
515-540 4.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.47e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462568506 515 HLRSHRGIHSGEKPYKCNECGKVFAQ 540
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 221-243 4.95e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.95e-03
                          10        20
                  ....*....|....*....|...
gi 2462568506 221 YKCNECGKAFTQNSNLTSHRRIH 243
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 753-775 5.73e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.73e-03
                          10        20
                  ....*....|....*....|...
gi 2462568506 753 YKCNECGKVFRQSSNLASHHRMH 775
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
683-708 5.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.77e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462568506 683 SLTTHQAIHTGKKPYKCNECGKVFTQ 708
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
319-344 6.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.18e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462568506 319 NLTTHQLIHTGEKPFKCNECGKLFTQ 344
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
571-596 7.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.02e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462568506 571 SLTFHQAIHTGEKPYKCHECGKVFRH 596
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 277-299 8.00e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 8.00e-03
                          10        20
                  ....*....|....*....|...
gi 2462568506 277 YKCHECGKVFRHNSYLATHRRIH 299
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 585-607 8.00e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 8.00e-03
                          10        20
                  ....*....|....*....|...
gi 2462568506 585 YKCHECGKVFRHNSYLATHRRIH 607
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
347-371 9.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.90e-03
                          10        20
                  ....*....|....*....|....*
gi 2462568506 347 HLISHWRIHTGEKPYKCNECGKAFS 371
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH