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Conserved domains on  [gi|2462580498|ref|XP_054179483|]
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prefoldin subunit 4 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prefoldin_4 cd23165
prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic ...
 66-169 1.07e-45

prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


:

Pssm-ID: 467481 [Multi-domain]  Cd Length: 103  Bit Score: 145.77  E-value: 1.07e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580498  66 DQQKINKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDcLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEI 145
Cdd:cd23165     1 DQQKINKFSRLNARLHELKEELKAKKKELENLEDASDELELADDD-EPVPYKIGEVFVHLSLEEAQERLEKAKEELEEEI 79

                          90       100
                  ....*....|....*....|....
gi 2462580498 146 DALESRVESIQRVLADLKVQLYAK 169
Cdd:cd23165    80 EKLEEEIDEIEEEMKELKVQLYAK 103
 
Name Accession Description Interval E-value
Prefoldin_4 cd23165
prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic ...
 66-169 1.07e-45

prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467481 [Multi-domain]  Cd Length: 103  Bit Score: 145.77  E-value: 1.07e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580498  66 DQQKINKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDcLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEI 145
Cdd:cd23165     1 DQQKINKFSRLNARLHELKEELKAKKKELENLEDASDELELADDD-EPVPYKIGEVFVHLSLEEAQERLEKAKEELEEEI 79

                          90       100
                  ....*....|....*....|....
gi 2462580498 146 DALESRVESIQRVLADLKVQLYAK 169
Cdd:cd23165    80 EKLEEEIDEIEEEMKELKVQLYAK 103
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 70-172 2.23e-20

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 81.12  E-value: 2.23e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580498  70 INKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDcLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEIDALE 149
Cdd:pfam01920   1 INKFQQLQQQLQLLAQQIKQLETQLKELELALEELELLDED-TKVYKLIGDVLVKQDKEEVKEQLEERKETLEKEIKTLE 79

                          90       100
                  ....*....|....*....|...
gi 2462580498 150 SRVESIQRVLADLKVQLYAKFGS 172
Cdd:pfam01920  80 KQLEKLEKELEELKEELYKKFGQ 102
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
56-166 8.98e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 35.99  E-value: 8.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580498  56 AAEDVNVTFEDQ---QKINKFARNTSRITELKEEIEVKKKQLQNLEDACDDImladddclmipyqigdvfishSQEETQE 132
Cdd:COG2433   402 EHEERELTEEEEeirRLEEQVERLEAEVEELEAELEEKDERIERLERELSEA---------------------RSEERRE 460

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462580498 133 MLEEAK-KNLQEEIDALESRVESIQRVLADLKVQL 166
Cdd:COG2433   461 IRKDREiSRLDREIERLERELEEERERIEELKRKL 495
 
Name Accession Description Interval E-value
Prefoldin_4 cd23165
prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic ...
 66-169 1.07e-45

prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467481 [Multi-domain]  Cd Length: 103  Bit Score: 145.77  E-value: 1.07e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580498  66 DQQKINKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDcLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEI 145
Cdd:cd23165     1 DQQKINKFSRLNARLHELKEELKAKKKELENLEDASDELELADDD-EPVPYKIGEVFVHLSLEEAQERLEKAKEELEEEI 79

                          90       100
                  ....*....|....*....|....
gi 2462580498 146 DALESRVESIQRVLADLKVQLYAK 169
Cdd:cd23165    80 EKLEEEIDEIEEEMKELKVQLYAK 103
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 70-172 2.23e-20

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 81.12  E-value: 2.23e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580498  70 INKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDcLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEIDALE 149
Cdd:pfam01920   1 INKFQQLQQQLQLLAQQIKQLETQLKELELALEELELLDED-TKVYKLIGDVLVKQDKEEVKEQLEERKETLEKEIKTLE 79

                          90       100
                  ....*....|....*....|...
gi 2462580498 150 SRVESIQRVLADLKVQLYAKFGS 172
Cdd:pfam01920  80 KQLEKLEKELEELKEELYKKFGQ 102
Prefoldin cd00890
prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and ...
 79-157 4.33e-18

prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits; the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes, there are two or more paralogous genes encoding each subunit, adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467470  Cd Length: 79  Bit Score: 74.30  E-value: 4.33e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462580498  79 RITELKEEIEVKKKQLQNLEDACDDIMLADDDCLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEIDALESRVESIQR 157
Cdd:cd00890     1 QVQALSQQIEQLNRQINELEEALDELSNLDKDTEEVYRSVGGVFIEKSKEETKEELEEKLDELQKEIKKLEQQLEAKTK 79
Prefoldin_beta cd00632
Prefoldin beta subunit; Beta subunits of prefoldin, a hexameric molecular chaperone complex, ...
 79-157 6.45e-17

Prefoldin beta subunit; Beta subunits of prefoldin, a hexameric molecular chaperone complex, found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467469  Cd Length: 78  Bit Score: 71.22  E-value: 6.45e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462580498  79 RITELKEEIEVKKKQLQNLEDACDDIMLADDdCLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEIDALESRVESIQR 157
Cdd:cd00632     1 EVLALKSQKEELERKINEQKVVLDELSNLKK-NRKVYRQQGNIFILASKEETLSELKKTLDHLQKEIKELEQQLKAKEK 78
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
56-166 8.98e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 35.99  E-value: 8.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462580498  56 AAEDVNVTFEDQ---QKINKFARNTSRITELKEEIEVKKKQLQNLEDACDDImladddclmipyqigdvfishSQEETQE 132
Cdd:COG2433   402 EHEERELTEEEEeirRLEEQVERLEAEVEELEAELEEKDERIERLERELSEA---------------------RSEERRE 460

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462580498 133 MLEEAK-KNLQEEIDALESRVESIQRVLADLKVQL 166
Cdd:COG2433   461 IRKDREiSRLDREIERLERELEEERERIEELKRKL 495
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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