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Conserved domains on  [gi|2462581839|ref|XP_054180126|]
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mRNA export factor RAE1 isoform X3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
105-401 1.08e-26

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 1.08e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 105 DDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQDsGQTIpKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSN 184
Cdd:COG2319   120 TGAVRSVAFSPD---GKTLASGSADGTVRLWDLAT-GKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 185 QAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErcycaDVIYPMA--------VVATAE 255
Cdd:COG2319   195 KLLRtLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS-----GSVRSVAfspdgrllASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 256 RGLIVYQLENqpsefRRIESPLKHQH---RCVAIFKDKQNkptgFALGSIEGRVAIHYINPPNPAKdnfTFKCHRSngtn 332
Cdd:COG2319   268 GTVRLWDLAT-----GELLRTLTGHSggvNSVAFSPDGKL----LASGSDDGTVRLWDLATGKLLR---TLTGHTG---- 331

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462581839 333 tsapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 401
Cdd:COG2319   332 --------AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
105-401 1.08e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 1.08e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 105 DDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQDsGQTIpKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSN 184
Cdd:COG2319   120 TGAVRSVAFSPD---GKTLASGSADGTVRLWDLAT-GKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 185 QAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErcycaDVIYPMA--------VVATAE 255
Cdd:COG2319   195 KLLRtLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS-----GSVRSVAfspdgrllASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 256 RGLIVYQLENqpsefRRIESPLKHQH---RCVAIFKDKQNkptgFALGSIEGRVAIHYINPPNPAKdnfTFKCHRSngtn 332
Cdd:COG2319   268 GTVRLWDLAT-----GELLRTLTGHSggvNSVAFSPDGKL----LASGSDDGTVRLWDLATGKLLR---TLTGHTG---- 331

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462581839 333 tsapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 401
Cdd:COG2319   332 --------AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-401 5.32e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.95  E-value: 5.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 106 DSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQdsGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQ 185
Cdd:cd00200    10 GGVTCVAFSPD---GKLLATGSGDGTIKVWDLE--TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 186 AIQ-IAQHDAPVKTIHWIkaPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErCYCADVIYP----MAVVATAERGLIV 260
Cdd:cd00200    85 CVRtLTGHTSYVSSVAFS--PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHT-DWVNSVAFSpdgtFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 261 YQLENqpseFRRIESPLKHQH--RCVAIFKDKQNkptgFALGSIEGRVAIHyinppnpakDNFTFKCHRSNGTNTSapqd 338
Cdd:cd00200   162 WDLRT----GKCVATLTGHTGevNSVAFSPDGEK----LLSSSSDGTIKLW---------DLSTGKCLGTLRGHEN---- 220

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462581839 339 iyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 401
Cdd:cd00200   221 --GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 151-180 4.24e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.24e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462581839  151 HTGPVLDVCWSDDGSKVFTASCDKTAKMWD 180
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
151-180 2.78e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.78e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462581839 151 HTGPVLDVCWSDDGSKVFTASCDKTAKMWD 180
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
105-401 1.08e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 1.08e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 105 DDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQDsGQTIpKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSN 184
Cdd:COG2319   120 TGAVRSVAFSPD---GKTLASGSADGTVRLWDLAT-GKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 185 QAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErcycaDVIYPMA--------VVATAE 255
Cdd:COG2319   195 KLLRtLTGHTGAVRSVAF--SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS-----GSVRSVAfspdgrllASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 256 RGLIVYQLENqpsefRRIESPLKHQH---RCVAIFKDKQNkptgFALGSIEGRVAIHYINPPNPAKdnfTFKCHRSngtn 332
Cdd:COG2319   268 GTVRLWDLAT-----GELLRTLTGHSggvNSVAFSPDGKL----LASGSDDGTVRLWDLATGKLLR---TLTGHTG---- 331

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462581839 333 tsapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 401
Cdd:COG2319   332 --------AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-401 5.32e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.95  E-value: 5.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 106 DSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQdsGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQ 185
Cdd:cd00200    10 GGVTCVAFSPD---GKLLATGSGDGTIKVWDLE--TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 186 AIQ-IAQHDAPVKTIHWIkaPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErCYCADVIYP----MAVVATAERGLIV 260
Cdd:cd00200    85 CVRtLTGHTSYVSSVAFS--PDGRILSSSSRDKTIKVWDVETGKCLTTLRGHT-DWVNSVAFSpdgtFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 261 YQLENqpseFRRIESPLKHQH--RCVAIFKDKQNkptgFALGSIEGRVAIHyinppnpakDNFTFKCHRSNGTNTSapqd 338
Cdd:cd00200   162 WDLRT----GKCVATLTGHTGevNSVAFSPDGEK----LLSSSSDGTIKLW---------DLSTGKCLGTLRGHEN---- 220

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462581839 339 iyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 401
Cdd:cd00200   221 --GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
40-401 9.27e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.38  E-value: 9.27e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839  40 AGLRRLRAPGISVRAPGPRPSRQSRFKMSLFGTTSGFGTSGTSMFGSATTDNHNPMKDIEVTSSPDDSIGCLSFSPPtlp 119
Cdd:COG2319    13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD--- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 120 GNFLIAGSWANDVRCWEVqdSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKT 198
Cdd:COG2319    90 GRLLASASADGTVRLWDL--ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRtLTGHSGAVTS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 199 IHWikAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPErcycaDVIYPMA--------VVATAERGLIVYQLENqpsef 270
Cdd:COG2319   168 VAF--SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT-----GAVRSVAfspdgkllASGSADGTVRLWDLAT----- 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 271 RRIESPLKHQH---RCVAIFKDkqnkptG--FALGSIEGRVAIHYINPPNPAKdnfTFKCHRSngtntsapqdiyAVNGI 345
Cdd:COG2319   236 GKLLRTLTGHSgsvRSVAFSPD------GrlLASGSADGTVRLWDLATGELLR---TLTGHSG------------GVNSV 294

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462581839 346 AFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 401
Cdd:COG2319   295 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSD 350
WD40 COG2319
WD40 repeat [General function prediction only];
104-226 2.99e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.28  E-value: 2.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 104 PDDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVqDSGQTIpKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSS 183
Cdd:COG2319   287 HSGGVNSVAFSPD---GKLLASGSDDGTVRLWDL-ATGKLL-RTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 2462581839 184 NQAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRS 226
Cdd:COG2319   362 GELLRtLTGHTGAVTSVAF--SPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
98-234 1.53e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.19  E-value: 1.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839  98 IEVTSSPDDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVQdsGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAK 177
Cdd:COG2319   239 LRTLTGHSGSVRSVAFSPD---GRLLASGSADGTVRLWDLA--TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462581839 178 MWDLSSNQAIQIAQ-HDAPVKTIHWikAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQ 234
Cdd:COG2319   314 LWDLATGKLLRTLTgHTGAVRSVAF--SPDGKTLASGSDDGTVRLWDLATGELLRTLT 369
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 151-401 5.01e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.84  E-value: 5.01e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 151 HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAI-QIAQHDAPVKTIHWIkaPNYSCVMTGSWDKTLKFWDTrssnp 229
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLrTLKGHTGPVRDVAAS--ADGTYLASGSSDKTIRLWDL----- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 230 mmvlqlpercycadviypmavvataerglivyqleNQPSEFRRIESplkHQH--RCVAIFKDKQnkptgFALGSIE-GRV 306
Cdd:cd00200    81 -----------------------------------ETGECVRTLTG---HTSyvSSVAFSPDGR-----ILSSSSRdKTI 117

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 307 AIHYINPPNPAkdnFTFKCHRSngtntsapqdiyAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISA 386
Cdd:cd00200   118 KVWDVETGKCL---TTLRGHTD------------WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNS 182

                         250
                  ....*....|....*
gi 2462581839 387 CCFNHNGNIFAYASS 401
Cdd:cd00200   183 VAFSPDGEKLLSSSS 197
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 105-223 7.06e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 7.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462581839 105 DDSIGCLSFSPPtlpGNFLIAGSWANDVRCWEVqDSGQTIpkaQQM--HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLS 182
Cdd:cd00200   177 TGEVNSVAFSPD---GEKLLSSSSDGTIKLWDL-STGKCL---GTLrgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2462581839 183 SNQAIQ-IAQHDAPVKTIHWikAPNYSCVMTGSWDKTLKFWD 223
Cdd:cd00200   250 TGECVQtLSGHTNSVTSLAW--SPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 151-180 4.24e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 4.24e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462581839  151 HTGPVLDVCWSDDGSKVFTASCDKTAKMWD 180
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
151-180 2.78e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.78e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462581839 151 HTGPVLDVCWSDDGSKVFTASCDKTAKMWD 180
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 192-223 1.13e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 1.13e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462581839  192 HDAPVKTIHWikAPNYSCVMTGSWDKTLKFWD 223
Cdd:smart00320  11 HTGPVTSVAF--SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
192-223 1.88e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.88e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462581839 192 HDAPVKTIHWikAPNYSCVMTGSWDKTLKFWD 223
Cdd:pfam00400  10 HTGSVTSLAF--SPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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