|
Name |
Accession |
Description |
Interval |
E-value |
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
1-744 |
0e+00 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 1425.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 1 MNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHG 80
Cdd:cd00764 18 MNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEFREREGRLQAAYNLIQRG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 81 ITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVI 160
Cdd:cd00764 98 ITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGTDMTIGTDSALHRICEVV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 161 DAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDR 240
Cdd:cd00764 178 DAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRSRGKRLNIIIVAEGAIDD 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 241 NGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLM 320
Cdd:cd00764 258 QLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTPACVVSLNGNKAVRLPLM 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 321 ECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPK--EKSNFSLAILNVGAPAAGMNAAVRSAVRTGIS 398
Cdd:cd00764 338 ECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPlpEKTNLNIAIVNVGAPAAGMNAAVRSAVRYGLA 417
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 399 HGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGVLQL 478
Cdd:cd00764 418 HGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGIDGLIIVGGFEAYKGLLQL 497
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 479 VEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAV 558
Cdd:cd00764 498 REAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVETMGGYCGYLATMTGLAV 577
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 559 GADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQGGAP 638
Cdd:cd00764 578 GADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGVFDCRTNVLGHVQQGGAP 657
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 639 TPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANAPDSACVIGLKKKAVAFSPVTELKKDTdFEHRMPREQWWLSLRLM 718
Cdd:cd00764 658 SPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTT-FEHRIPKEQWWLSLRPL 736
|
730 740
....*....|....*....|....*.
gi 2462582655 719 LKMLAQYRISMAAYVSGELEHVTRRT 744
Cdd:cd00764 737 LKILAKYKISADISDHGQLEHVTRGQ 762
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
1-726 |
0e+00 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 1181.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 1 MNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHG 80
Cdd:TIGR02478 15 MNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRERPGRLKAARNLVSNG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 81 ITNLCVIGGDGSLTGANIFRSEWGSLLEELVAEGKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVI 160
Cdd:TIGR02478 95 IDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMTIGADSALHRICEAI 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 161 DAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDR 240
Cdd:TIGR02478 175 DAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGKRKTIVIVAEGAIDR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 241 NGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLM 320
Cdd:TIGR02478 255 DLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPVISLRGNKIVRKPLV 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 321 ECVQMTKEVQKAMDDKRFDEATQLRGGSFENNWNIYKLLAHQKPPK-----EKSNFSLAILNVGAPAAGMNAAVRSAVRT 395
Cdd:TIGR02478 335 EAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKklvpsEASRLRIAIIHVGAPAGGMNAATRSAVRY 414
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 396 GISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLESIVENIRIYGIHALLVVGGFEAYEGV 475
Cdd:TIGR02478 415 ALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKIDGLIIIGGFEAFEAL 494
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 476 LQLVEARGRYEELCIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTG 555
Cdd:TIGR02478 495 YQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVETMGGYSGYLATMAG 574
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 556 IAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKTDIQRGLVLRNEKCHDYYTTEFLYNLYSSEGKGVFDCRTNVLGHLQQG 635
Cdd:TIGR02478 575 LATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGRFDARTAVLGHMQQG 654
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 636 GAPTPFDRNYGTKLGVKAMLWLSEKLREVYRKGRVFANaPDSACVIGLKKKAVAFSPV-TELKKDTDFEHRMPREQWWLS 714
Cdd:TIGR02478 655 GSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSAD-DTSAVVIGIRGSNVLFTPVkQLLANETDFEHRRPKNQWWLQ 733
|
730
....*....|..
gi 2462582655 715 LRLMLKMLAQYR 726
Cdd:TIGR02478 734 LRPLVRILAGRD 745
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
1-354 |
2.42e-178 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 513.38 E-value: 2.42e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 1 MNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHG 80
Cdd:cd00363 15 MNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTEEGRAKAAENLKKHG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 81 ITNLCVIGGDGSLTGANIFRSEWGSlleelvaegkisettarTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVI 160
Cdd:cd00363 93 IDALVVIGGDGSYTGADLLTEEWPS-----------------KYQGFNVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 161 DAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWENFMCERLGETRSRGSRLNIIIIAEGAIDR 240
Cdd:cd00363 156 DRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERGKRHGIVIVAEGAIDF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 241 NGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTPACVVTLSGNQSVRLPLM 320
Cdd:cd00363 236 IPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVGIQNLNENQVVRHPLT 315
|
330 340 350
....*....|....*....|....*....|....
gi 2462582655 321 ECVQMTKEVQkamddkrfdeaTQLRGGSFENNWN 354
Cdd:cd00363 316 EAVNMTKRVG-----------VDLEGRPFKKFAK 338
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
1-292 |
2.03e-130 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 387.85 E-value: 2.03e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 1 MNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHG 80
Cdd:pfam00365 14 MNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEG--DIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGREKIAENLKKLG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 81 ITNLCVIGGDGSLTGANIFRSEWGslleelvaegkisettartyshLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVI 160
Cdd:pfam00365 92 IDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 161 DAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEdgwENFMCERLgETRSRGSRLNIIIIAEGAIDr 240
Cdd:pfam00365 150 DRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELCEKI-KELRKGKRFSIIVVAEGASD- 224
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 2462582655 241 ngkpisSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAV 292
Cdd:pfam00365 225 ------GEFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
|
|
| PFK |
pfam00365 |
Phosphofructokinase; |
373-654 |
1.55e-121 |
|
Phosphofructokinase;
Pssm-ID: 459783 [Multi-domain] Cd Length: 271 Bit Score: 365.12 E-value: 1.55e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 373 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPKGQLES-- 450
Cdd:pfam00365 2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEGre 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 451 -IVENIRIYGIHALLVVGGFEAYEGVLQLVEARGryeelcIVMCVIPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQS 529
Cdd:pfam00365 82 kIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 530 ASGTkRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTeKMKTDIqrgLVLRNEKCHDyytTEF 609
Cdd:pfam00365 156 ASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELR-KGKRFS---IIVVAEGASD---GEF 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 2462582655 610 LYNLYssEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAM 654
Cdd:pfam00365 228 LAKLI--EEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
1-329 |
1.94e-111 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 341.67 E-value: 1.94e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 1 MNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHG 80
Cdd:COG0205 16 LNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTEEGREKALENLKKLG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 81 ITNLCVIGGDGSLTGANIFRSEWGslleelvaegkisettartyshLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVI 160
Cdd:COG0205 94 IDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 161 DAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEdgwENFMCERLGETRSRGSRLNIIIIAEGAIDR 240
Cdd:COG0205 152 DRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGKGYSIIVVAEGAGDE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 241 NGKPISSS---------------YVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEatpDTPAC 305
Cdd:COG0205 229 DGEAVLEAdtdafghvrlggigeYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLE---GKTGV 305
|
330 340
....*....|....*....|....
gi 2462582655 306 VVTLSGNQSVRLPLMECVQMTKEV 329
Cdd:COG0205 306 MVGIRRGEIVLVPLEEVANKEKPV 329
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
1-336 |
6.81e-110 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 336.67 E-value: 6.81e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 1 MNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHG 80
Cdd:PRK03202 16 MNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDEEGRAKAIENLKKLG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 81 ITNLCVIGGDGSLTGANIFrSEWGslleelvaegkisettartyshLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVI 160
Cdd:PRK03202 94 IDALVVIGGDGSYMGAKRL-TEHG----------------------IPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 161 DAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAP--PEDgwenfMCERLGETRSRGSRLNIIIIAEGAI 238
Cdd:PRK03202 151 DRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPfdIEE-----LCAKIKKGRERGKKHAIIVVAEGVM 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 239 DRNGkpisssyVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDTpacVVTLSGNQSVRLP 318
Cdd:PRK03202 226 PAEE-------LAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGR---MVGIQNNKIVHVP 295
|
330
....*....|....*....
gi 2462582655 319 LMECV-QMTKEVQKAMDDK 336
Cdd:PRK03202 296 IEEAVeNMKHPFDKDLYEL 314
|
|
| PFKA_ATP |
TIGR02482 |
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ... |
1-321 |
3.35e-101 |
|
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 213713 [Multi-domain] Cd Length: 301 Bit Score: 313.52 E-value: 3.35e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 1 MNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHG 80
Cdd:TIGR02482 14 MNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEEVREKAVENLKKLG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 81 ITNLCVIGGDGSLTGANIfrsewgslleeLVAEGKIsettartyshlNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVI 160
Cdd:TIGR02482 92 IEGLVVIGGDGSYTGAQK-----------LYEEGGI-----------PVIGLPGTIDNDIPGTDYTIGFDTALNTIIDAV 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 161 DAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEA--PPEDgwenfMCERLGETRSRGSRLNIIIIAEGAI 238
Cdd:TIGR02482 150 DKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFdyDIDE-----LIQRLKEQHEAGKKHSIIIVAEGNI 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 239 DRNGKPISSSyVKDlvvqRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEatpDTPACVVTLSGNQSVRLP 318
Cdd:TIGR02482 225 VGSAKEVAKK-IEE----KTGIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLE---GKGGVMIGIQNNKIVTHP 296
|
...
gi 2462582655 319 LME 321
Cdd:TIGR02482 297 IEE 299
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
1-333 |
8.22e-88 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 279.29 E-value: 8.22e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 1 MNAAVRAVTRMGIYVGAKVFLIYEGYEGLVEGgeNIKQANWLSVSNIIQLGGTIIGSARCKAFTTREGRRAAAYNLVQHG 80
Cdd:cd00763 15 MNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDEEGQAKAIEQLKKHG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 81 ITNLCVIGGDGSLTGAnifrsewgsllEELVAEGkisettartyshLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVI 160
Cdd:cd00763 93 IDALVVIGGDGSYMGA-----------MRLTEHG------------FPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAI 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 161 DAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAP--PEDgwenfMCERLGETRSRGSRLNIIIIAEGAI 238
Cdd:cd00763 150 DRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEfdREE-----VANRIKAGIERGKKHAIVVVAEGVY 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 239 DRNGkpisssyVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEAtpdTPACVVTLSGNQSVRLP 318
Cdd:cd00763 225 DVDE-------LAKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAG---KGGLAVGIQNEQLVHHD 294
|
330
....*....|....*
gi 2462582655 319 LMECVQMTKEVQKAM 333
Cdd:cd00763 295 IIDAIENMKPFKKDW 309
|
|
| PFK_mixed |
TIGR02483 |
phosphofructokinase; Members of this family that are characterized, save one, are ... |
1-323 |
1.20e-69 |
|
phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 274155 [Multi-domain] Cd Length: 324 Bit Score: 231.42 E-value: 1.20e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 1 MNAAVRAVTRMGIYV-GAKVFLIYEGYEGLVEGGEnIKQANWLSVSNIIQLGGTIIGSARCKAFTT-REGRRAAAYNLVQ 78
Cdd:TIGR02483 14 LNAVIRGVVRRAIAEyGWEVIGIRDGWRGLLEGDT-VPLLDLEDVRGILPRGGTILGSSRTNPFKYeEDGDDKIVANLKE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 79 HGITNLCVIGGDGSLTGANifrsewgslleELVAEGkisettartyshLNIAGLVGSIDNDFCGTDMTIGTDSALHRIME 158
Cdd:TIGR02483 93 LGLDALIAIGGDGTLGIAR-----------RLADKG------------LPVVGVPKTIDNDLEATDYTFGFDTAVEIATE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 159 VIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEdgWENfMCERLGETRSRGSRLNIIIIAEGAI 238
Cdd:TIGR02483 150 ALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPFD--IDS-VCEKVRERFARGKRFAIVVVAEGAK 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 239 DRNGKPISSSYVKD----------------LVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMALLEATPDT 302
Cdd:TIGR02483 227 PKGGEMVVQEGVKDafghvrlggignwlaeEIERRTGIETRATVLGHLQRGGSPSAFDRVLATRFGVAAVDLVHEGQFGH 306
|
330 340
....*....|....*....|.
gi 2462582655 303 pacVVTLSGNQSVRLPLMECV 323
Cdd:TIGR02483 307 ---MVALRGTDIVYVPIAEAV 324
|
|
| PfkA |
COG0205 |
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ... |
373-659 |
1.23e-67 |
|
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 439975 [Multi-domain] Cd Length: 344 Bit Score: 226.49 E-value: 1.23e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 373 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRTLPK---GQLE 449
Cdd:COG0205 4 IGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFkteEGRE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 450 SIVENIRIYGIHALLVVGGFEAYEGVLQLVEARGryeelciVMCV-IPATISNNVPGTDFSLGSDTAVNAAMESCDRIKQ 528
Cdd:COG0205 84 KALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG-------IPVVgIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 529 SASGTkRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLkvnVEHMTEKMKTDIQRGLVL--------RNEK 600
Cdd:COG0205 157 TAASH-ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGYSIIVvaegagdeDGEA 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462582655 601 CHDYYTTEFLYNLYSSEGKGV---------FDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSE 659
Cdd:COG0205 233 VLEADTDAFGHVRLGGIGEYLakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLE 300
|
|
| PRK03202 |
PRK03202 |
ATP-dependent 6-phosphofructokinase; |
373-653 |
2.21e-66 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235111 [Multi-domain] Cd Length: 320 Bit Score: 222.65 E-value: 2.21e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 373 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRT----LPKGQL 448
Cdd:PRK03202 4 IGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFpefkDEEGRA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 449 EsIVENIRIYGIHALLVVGGFEAYEGVLQLVEARgryeelciVMCV-IPATISNNVPGTDFSLGSDTAVNAAMESCDRIK 527
Cdd:PRK03202 84 K-AIENLKKLGIDALVVIGGDGSYMGAKRLTEHG--------IPVIgLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 528 QSASgTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLkvnVEHMTEKMKTDIQRGLVLRNEKCHD--YY 605
Cdd:PRK03202 155 DTAS-SHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEEL---CAKIKKGRERGKKHAIIVVAEGVMPaeEL 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2462582655 606 TTEFlynlyssEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKA 653
Cdd:PRK03202 231 AKEI-------EERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHA 271
|
|
| PFK |
cd00363 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
372-696 |
1.77e-60 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.
Pssm-ID: 238216 [Multi-domain] Cd Length: 338 Bit Score: 207.15 E-value: 1.77e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 372 SLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKRT----LPKGQ 447
Cdd:cd00363 2 KIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCkefrTEEGR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 448 LESIvENIRIYGIHALLVVGGFEAYEGVLQLVE-ARGRYEELCIVMCviPATISNNVPGTDFSLGSDTAVNAAMESCDRI 526
Cdd:cd00363 82 AKAA-ENLKKHGIDALVVIGGDGSYTGADLLTEeWPSKYQGFNVIGL--PGTIDNDIKGTDYTIGFDTALKTIVEAIDRI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 527 KQSASgTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNihdlKVNVEHMTEKMKTDIQRG----LVLRNEKch 602
Cdd:cd00363 159 RDTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAA----DEWEEEMVDVIKKRRERGkrhgIVIVAEG-- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 603 dyyTTEFLYNLYSSEG-------KGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLSEKLREVyrkgrvfanap 675
Cdd:cd00363 232 ---AIDFIPKPITEKLlaklveeRLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGT----------- 297
|
330 340
....*....|....*....|.
gi 2462582655 676 dSACVIGLKKKAVAFSPVTEL 696
Cdd:cd00363 298 -PVGIQNLNENQVVRHPLTEA 317
|
|
| Bacterial_PFK |
cd00763 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
373-653 |
4.32e-58 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.
Pssm-ID: 238388 [Multi-domain] Cd Length: 317 Bit Score: 199.94 E-value: 4.32e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 373 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSMLGTKR----TLPKGQL 448
Cdd:cd00763 3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSARfpefKDEEGQA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 449 ESIvENIRIYGIHALLVVGGFEAYEGVLQLVEARgryeelciVMCV-IPATISNNVPGTDFSLGSDTAVNAAMESCDRIK 527
Cdd:cd00763 83 KAI-EQLKKHGIDALVVIGGDGSYMGAMRLTEHG--------FPCVgLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 528 QSASgTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIHDLKVNVEHMTEKMKtdiQRGLVLRNEkcHDYYTT 607
Cdd:cd00763 154 DTSS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGK---KHAIVVVAE--GVYDVD 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 2462582655 608 EFLYNLyssEGKGVFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKA 653
Cdd:cd00763 228 ELAKEI---EEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYA 270
|
|
| 6PF1K_euk |
TIGR02478 |
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ... |
373-706 |
4.35e-49 |
|
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).
Pssm-ID: 274152 [Multi-domain] Cd Length: 746 Bit Score: 184.85 E-value: 4.35e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 373 LAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKGQ--VQEVGWHDVAGWLGRGGSMLGTKRTLP----KG 446
Cdd:TIGR02478 3 IAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGdnIEEAQWEDVRGILSLGGTIIGTARCKEfrerPG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 447 QLESiVENIRIYGIHALLVVGGFEAYEG-----------VLQLV-------EARGRYEELCIVMCVipATISNNVPGTDF 508
Cdd:TIGR02478 83 RLKA-ARNLVSNGIDALVVIGGDGSLTGadlfreewpslLEELVdtgkitaEQAEEHRHLTIVGLV--GSIDNDMCGTDM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 509 SLGSDTAVNAAMESCDRIKQSASGTKrRVFIVETMGGYCGYLATVTGIAVGADaaYVF--EDPfnihdLKVN-VEHMTEK 585
Cdd:TIGR02478 160 TIGADSALHRICEAIDAISSTAQSHQ-RAFVVEVMGRHCGYLALMAAIATGAD--YVFipERP-----PEEGwEDQLCHK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 586 MKTDIQRG----LVLRNEKCHD----YYTTEFLYNLYSSEGKgvFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWL 657
Cdd:TIGR02478 232 LKRNRKAGkrktIVIVAEGAIDrdlnPITSEDVKDVLVERLG--LDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAV 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2462582655 658 SEKLREvyrkgrvfanAPdsACVIGLKK---------KAVAFS-PVTELKKDTDFEHRM 706
Cdd:TIGR02478 310 LESTPE----------TP--SPVISLRGnkivrkplvEAVAQTkTVAKAIEEKDFDEAM 356
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
1-330 |
4.41e-48 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 173.72 E-value: 4.41e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 1 MNAAVRAVTR--MGIYvGAKVFLIYEGYEGLVEGGENIKQANWLSVSNIIQLGGTIIGSARcK----AFTTREG----RR 70
Cdd:PRK14071 19 LNAVIRAVVHraRGTY-GWEVIGIRDATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTN-KgdpfAFPMPDGslrdRS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 71 A---AAYNlvQHGITNLCVIGGDGSLtganifrsewgSLLEELVAEGKIsettartyshlNIAGLVGSIDNDFCGTDMTI 147
Cdd:PRK14071 97 QeiiDGYH--SLGLDALIGIGGDGSL-----------AILRRLAQQGGI-----------NLVGIPKTIDNDVGATEVSI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 148 GTDSALHRIMEVIDAITTTAQSHQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEdgWENfMCERLGETRSRGSR 227
Cdd:PRK14071 153 GFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYT--LEN-VCKKIRERQEEGKN 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 228 LNIIIIAEGAIDRNGKPIS-------------SSYVKDLVVQRLGFDTRVTVLGHVQRGGTPSAFDRILSSKMGMEAVMA 294
Cdd:PRK14071 230 FCLVVVSEAVRTEEGEQVTktqalgedryggiGQYLAEQIAERTGAETRVTVLGHIQRGGIPSPRDRLLASAFGVAAVDL 309
|
330 340 350
....*....|....*....|....*....|....*.
gi 2462582655 295 LLEATPDTpacVVTLSGNQSVRLPLMECVQMTKEVQ 330
Cdd:PRK14071 310 IAQGKFDR---MVAWQNRQVVSVPIAEAIATYRAVD 342
|
|
| Eukaryotic_PFK |
cd00764 |
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ... |
372-716 |
1.40e-44 |
|
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.
Pssm-ID: 238389 [Multi-domain] Cd Length: 762 Bit Score: 171.54 E-value: 1.40e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 372 SLAILNVGAPAAGMNAAVRSAVRTGISHGHTVYVVHDGFEGLAKG--QVQEVGWHDVAGWLGRGGSMLGTKR----TLPK 445
Cdd:cd00764 5 AIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGgdYIKQAEWESVSNWLQEGGTIIGSARckefRERE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 446 GQLESIVeNIRIYGIHALLVVGGFEAYEG-----------VLQLV-------EARGRYEELCIVMCVipATISNNVPGTD 507
Cdd:cd00764 85 GRLQAAY-NLIQRGITNLCVIGGDGSLTGadlfrsewpslLEELVkdgkiteEEVAKYQHLNIVGMV--GSIDNDFCGTD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 508 FSLGSDTAVNAAMESCDRIKQSASgTKRRVFIVETMGGYCGYLATVTGIAVGADaaYVF------EDPFNIHDLKVNVEH 581
Cdd:cd00764 162 MTIGTDSALHRICEVVDAITTTAQ-SHQRTFVLEVMGRHCGYLALVSGLATGAD--WIFiperppEDGWEDQMCRRLSEH 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 582 MTEKMKTDI---QRGLVLRNEKChdyYTTEFLYNLYSSEGKgvFDCRTNVLGHLQQGGAPTPFDRNYGTKLGVKAMLWLS 658
Cdd:cd00764 239 RSRGKRLNIiivAEGAIDDQLKP---ITSEDVKDLVVERLG--LDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462582655 659 EklrevyrkgrvfaNAPDS-ACVIGLKKKAVAFSPVTE---LKKDTDFEHRMPREQWWLSLR 716
Cdd:cd00764 314 E-------------ATPDTpACVVSLNGNKAVRLPLMEcvqLTKDVQKAMDEKRFDEAAALR 362
|
|
| PRK14071 |
PRK14071 |
ATP-dependent 6-phosphofructokinase; |
375-653 |
1.02e-30 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 184487 [Multi-domain] Cd Length: 360 Bit Score: 124.03 E-value: 1.02e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 375 ILNVGAPAAGMNAAVRSAVRTGISH-GHTVYVVHDGFEGLAKG--QVQEVGWHDVAGWLGRGGSMLGTKRT-------LP 444
Cdd:PRK14071 9 ILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTTNKgdpfafpMP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 445 KGQL----ESIVENIRIYGIHALLVVGGfeayEGVLQLVEargryeELC----IVMCVIPATISNNVPGTDFSLGSDTAV 516
Cdd:PRK14071 89 DGSLrdrsQEIIDGYHSLGLDALIGIGG----DGSLAILR------RLAqqggINLVGIPKTIDNDVGATEVSIGFDTAV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 517 NAAMESCDRIKQSASgTKRRVFIVETMGGYCGYLATVTGIAVGADAAYVFEDPFNIhdlkvnvEHMTEKMKTDIQRG--- 593
Cdd:PRK14071 159 NIATEALDRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTL-------ENVCKKIRERQEEGknf 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462582655 594 -LVLRNEKCHDY------YTTEFLYNLYSSEGKGVFD---------CRTNVLGHLQQGGAPTPFDRNYGTKLGVKA 653
Cdd:PRK14071 231 cLVVVSEAVRTEegeqvtKTQALGEDRYGGIGQYLAEqiaertgaeTRVTVLGHIQRGGIPSPRDRLLASAFGVAA 306
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
1-237 |
1.33e-23 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 104.74 E-value: 1.33e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 1 MNAAVRAVTRMGIYV-GAK-VFLIYEGYEGLVEggENIKQANWLSVSNIIQLGGTIIGSARcKAFTTREgrraAAYNLVQ 78
Cdd:PTZ00286 102 LNVVIRELVMNLINNyGVKtIYGAKYGYKGLYK--EDWIKLDPKDVKTIHRLGGTILGSSR-GGFDPKV----MVDTLIR 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 79 HGITNLCVIGGDGSLTGANifrsewgSLLEELVAEG-KISettartyshlnIAGLVGSIDNDFCGTDMTIGTDSALHRIM 157
Cdd:PTZ00286 175 HGINILFTLGGDGTHRGAL-------AIYKELRRRKlNIS-----------VVGIPKTIDNDIPIIDESFGFQTAVEEAQ 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 158 EVIDAITTTAQSHQRTF-VLEVMGRHCGYLALVSALASG-ADWLFIPEAP-PEDGWENFMCERLGETRSRgsrlnIIIIA 234
Cdd:PTZ00286 237 NAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPEFDiPLEGVLEYIEQRLQKKGHC-----VIVVA 311
|
...
gi 2462582655 235 EGA 237
Cdd:PTZ00286 312 EGA 314
|
|
| PTZ00286 |
PTZ00286 |
6-phospho-1-fructokinase; Provisional |
365-572 |
5.42e-18 |
|
6-phospho-1-fructokinase; Provisional
Pssm-ID: 185539 Cd Length: 459 Bit Score: 87.41 E-value: 5.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 365 PKEKSNFS-----LAILNVGAPAAGMNAAVRSAVRTGIS--HGHTVYVVHDGFEGLAKGQVQEVGWHDVAGWLGRGGSML 437
Cdd:PTZ00286 77 PRKHLYFNpkevkAGIVTCGGLCPGLNVVIRELVMNLINnyGVKTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTIL 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 438 GTKRTlpkGQ-LESIVENIRIYGIHALLVVGGFEAYEGVLQL-VEARGRYEELCIvmCVIPATISNNVPGTDFSLGSDTA 515
Cdd:PTZ00286 157 GSSRG---GFdPKVMVDTLIRHGINILFTLGGDGTHRGALAIyKELRRRKLNISV--VGIPKTIDNDIPIIDESFGFQTA 231
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 2462582655 516 VNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVG-ADAAYVFEDPFNI 572
Cdd:PTZ00286 232 VEEAQNAIRAAYVEAKSAKNGVGIVKLMGRDSGFIALHASVASAdVNVCLIPEFDIPL 289
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
25-237 |
1.93e-17 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 85.69 E-value: 1.93e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 25 GYEGLV-EGGENIKQANWLSVSNIIQLGGTIIGSARckafttreGRRAAAY---NLVQHGITNLCVIGGDGSLTGANifr 100
Cdd:PRK06830 121 GYQGLIpRYGHDPVELTPEVVADIHEFGGTILGSSR--------GPQDPEEivdTLERMNINILFVIGGDGTLRGAS--- 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 101 sewgslleelvaegKISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQSHQRTFVL-EVM 179
Cdd:PRK06830 190 --------------AIAEEIERRGLKISVIGIPKTIDNDINFIQKSFGFETAVEKATEAIRCAHVEANGAPNGIGLvKLM 255
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 180 GRHCGYLALVSALASG-ADWLFIPEAPPE-DGWENFMcERLgETRSRGSRLNIIIIAEGA 237
Cdd:PRK06830 256 GRHSGFIAAYAALASKdVNFVLIPEVPFDlEGPNGLL-AAL-EKRLAERGHAVIVVAEGA 313
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
18-237 |
3.11e-15 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 79.02 E-value: 3.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 18 KVFLIYEGYEGLVegGENIKQANWLSVSNIIQLGGTIIGSARCKAFTTRegrraAAYNLVQHGITNLCVIGGDGSLTGAN 97
Cdd:PLN02564 121 RILGIDGGYRGFY--SRNTIPLTPKVVNDIHKRGGTILGTSRGGHDTSK-----IVDSIQDRGINQVYIIGGDGTQKGAS 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 98 ifrsewgSLLEELVAEG-KISettartyshlnIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITTTAQS-HQRTFV 175
Cdd:PLN02564 194 -------VIYEEIRRRGlKVA-----------VAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESvENGIGL 255
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462582655 176 LEVMGRHCGYLALVSALAS-GADWLFIPEAP----PEDGWENFMCERLGETRSRgsrlnIIIIAEGA 237
Cdd:PLN02564 256 VKLMGRYSGFIAMYATLASrDVDCCLIPESPfyleGKGGLFEFIEKRLKENGHM-----VIVVAEGA 317
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
136-303 |
7.75e-15 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 77.21 E-value: 7.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 136 IDNDFCGTDMTIGTDSALHRI----MEV-IDAITTTAQShqRTFVLEVMGRHCGYLALVSALAS-----GADWLFIPEAP 205
Cdd:PRK14072 142 IDNDLPGTDHCPGFGSAAKYIatsvLEAaLDVAAMANTS--KVFILEVMGRHAGWLAAAAALAKqnpddAPHLIYLPERP 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 206 PEDgwENFMcERLGETRSRGSRLnIIIIAEGAIDRNGKPISSS-----------------YVKDLVVQRLGFDTRVTVLG 268
Cdd:PRK14072 220 FDE--EKFL-ADVRAIVKRYGYC-VVVVSEGIRDADGKFIAEAglaedafghaqlggvapVLANLIKEKLGKKVHWAVLD 295
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 2462582655 269 HVQR--GGTPSAFDR---ILSSKM-------GMEAVMALLEATPDTP 303
Cdd:PRK14072 296 YLQRaaRHIASKTDVeeaYAVGKAaveyalaGKNGVMPAIRRTSDDP 342
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
1-329 |
5.79e-12 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 68.30 E-value: 5.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 1 MNAAVRA-VTRMGIYVGAKVFLIYEGYEGLVEggENIKQANwLS---VSNIIQLGGTIIGSARCKAFTTRegrraAAYNL 76
Cdd:PLN02884 68 LNDVIRQiVFTLEIYGVKNIVGIPFGYRGFFE--KGLSEMP-LSrkvVQNIHLSGGSLLGVSRGGAKTSD-----IVDSI 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 77 VQHGITNLCVIGGDGSLTGANIfrsewgslleelvaegkISETTARTYSHLNIAGLVGSIDNDFCGTDMTIGTDSALHRI 156
Cdd:PLN02884 140 EARGINMLFVLGGNGTHAGANA-----------------IHNECRKRKMKVSVVGVPKTIDNDILLMDKTFGFDTAVEEA 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 157 MEVIDAITTTAQSHQRTF-VLEVMGRHCGYLALVSALASG-ADWLFIPEAPPE-DGWENFM--CERLGETRSRGsrlnII 231
Cdd:PLN02884 203 QRAINSAYIEAHSAYHGIgLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTlDGPNGVLrhLEHLIETKGSA----VV 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 232 IIAEGA-IDRNGKPISSSYVKDLVVQRLGFDTRVTVLGHVQRGGTPS-----------------AFDRILSSKMGMEAVM 293
Cdd:PLN02884 279 CVAEGAgQDLLQKTNATDASGNPVLGDIGVHLQQEIKKHFKDIGVPAdvkyidptymiracranASDAILCTVLGQNAVH 358
|
330 340 350
....*....|....*....|....*....|....*.
gi 2462582655 294 AlleATPDTPACVVTLSGNQSVRLPLMECVQMTKEV 329
Cdd:PLN02884 359 G---AFAGFSGITVGICNTHYVYLPIPEVIAYPRRV 391
|
|
| PLN02884 |
PLN02884 |
6-phosphofructokinase |
361-585 |
8.93e-12 |
|
6-phosphofructokinase
Pssm-ID: 178472 [Multi-domain] Cd Length: 411 Bit Score: 67.91 E-value: 8.93e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 361 HQKPPKEKSNF-----SLAILNVGAPAAGMNAAVRSAVRT----------GISHGHTvyvvhdGF--EGLA-----KGQV 418
Cdd:PLN02884 39 HRAGPRKKIYFepeevKAAIVTCGGLCPGLNDVIRQIVFTleiygvknivGIPFGYR------GFfeKGLSemplsRKVV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 419 QEVGWHdvagwlgrGGSMLGTKRTLPKgqLESIVENIRIYGIHALLVVGGFEAYEGVLQL-VEARGRYEELCIVmCViPA 497
Cdd:PLN02884 113 QNIHLS--------GGSLLGVSRGGAK--TSDIVDSIEARGINMLFVLGGNGTHAGANAIhNECRKRKMKVSVV-GV-PK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 498 TISNNVPGTDFSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAVG-ADAAYVFEDPFNIH--- 573
Cdd:PLN02884 181 TIDNDILLMDKTFGFDTAVEEAQRAINSAYIEAHSAYHGIGLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDgpn 260
|
250
....*....|..
gi 2462582655 574 DLKVNVEHMTEK 585
Cdd:PLN02884 261 GVLRHLEHLIET 272
|
|
| PRK06830 |
PRK06830 |
ATP-dependent 6-phosphofructokinase; |
384-573 |
1.92e-10 |
|
ATP-dependent 6-phosphofructokinase;
Pssm-ID: 235869 Cd Length: 443 Bit Score: 63.73 E-value: 1.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 384 GMNAAVRSAVRTGishgHTVYVVHD------GFEGLakgqVQEVGwHD--------VAGWLGRGGSMLGTKRtlpkGQ-- 447
Cdd:PRK06830 94 GLNDVIRAIVLEL----HHHYGVRRilgiryGYQGL----IPRYG-HDpveltpevVADIHEFGGTILGSSR----GPqd 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 448 LESIVENIRIYGIHALLVVGGFEAYEGVLQLV-EARGRYEELCIVmcVIPATISNNVPGTDFSLGSDTAVNAAMESCDRI 526
Cdd:PRK06830 161 PEEIVDTLERMNINILFVIGGDGTLRGASAIAeEIERRGLKISVI--GIPKTIDNDINFIQKSFGFETAVEKATEAIRCA 238
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 2462582655 527 KQSASGTKRRVFIVETMGGYCGYLATVTGIAVgADAAYVF--EDPFNIH 573
Cdd:PRK06830 239 HVEANGAPNGIGLVKLMGRHSGFIAAYAALAS-KDVNFVLipEVPFDLE 286
|
|
| PLN02564 |
PLN02564 |
6-phosphofructokinase |
432-570 |
8.54e-10 |
|
6-phosphofructokinase
Pssm-ID: 178178 Cd Length: 484 Bit Score: 61.69 E-value: 8.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 432 RGGSMLGTKRtlpKGQ-LESIVENIRIYGIHALLVVGGFEAYEG---VLQLVEARGryeeLCIVMCVIPATISNNVPGTD 507
Cdd:PLN02564 151 RGGTILGTSR---GGHdTSKIVDSIQDRGINQVYIIGGDGTQKGasvIYEEIRRRG----LKVAVAGIPKTIDNDIPVID 223
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462582655 508 FSLGSDTAVNAAMESCDRIKQSASGTKRRVFIVETMGGYCGYLATVTGIAV-GADAAYVFEDPF 570
Cdd:PLN02564 224 KSFGFDTAVEEAQRAINAAHVEAESVENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESPF 287
|
|
| PRK06555 |
PRK06555 |
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated |
25-237 |
9.41e-08 |
|
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
Pssm-ID: 180620 [Multi-domain] Cd Length: 403 Bit Score: 55.01 E-value: 9.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 25 GYEGLVeGGENI-------KQANWLSvsniiQLGGTIIGSARCKAFTT---------REGR---RAAAYNLVQHGITNLC 85
Cdd:PRK06555 44 GYQGLL-LGDSIeitpavrANAGLLH-----RYGGSPIGNSRVKLTNVadcvkrglvKEGEnplKVAAERLAADGVDILH 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 86 VIGGDGSLTGAnifrsewGSLLEELVAEGkisettartYsHLNIAGLVGSIDNDFCGTDMTIGTDSALHRIMEVIDAITT 165
Cdd:PRK06555 118 TIGGDDTNTTA-------ADLAAYLAENG---------Y-DLTVVGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVIN 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 166 TAQSHQRTFVL-EVMGRHCGYLALVSALA-----SGADWL---------------FIPEAPPEDGWEnfmCERLGETRSR 224
Cdd:PRK06555 181 EHSANPRMLIIhEVMGRNCGWLTAATARAyrewlDRQEYVpgfglsaerwdihavYLPEMAFDLEAE---AERLKAVMDE 257
|
250
....*....|...
gi 2462582655 225 GSRLNiIIIAEGA 237
Cdd:PRK06555 258 VGNVN-IFLSEGA 269
|
|
| PRK14072 |
PRK14072 |
diphosphate--fructose-6-phosphate 1-phosphotransferase; |
379-637 |
6.99e-07 |
|
diphosphate--fructose-6-phosphate 1-phosphotransferase;
Pssm-ID: 237600 [Multi-domain] Cd Length: 416 Bit Score: 52.17 E-value: 6.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 379 GAPAAGMNAAVRSAVRTGISHG--HTVYVVHDGFEGLAKGQV---QEVGWHDVAGWLGRGGSMLGTKRTLPKG------Q 447
Cdd:PRK14072 12 GGPTAVINASAAGVIEEARKHKkiGKVYGARNGIIGILDEDLidlSKESDEALAALAHTPSGALGSCRYKLKSleedraE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 448 LESIVENIRIYGIHALLVVGG---FEAYEGVLQLVEARGrYEELCIVmcvIPATISNNVPGTDFSLGSDTAVN----AAM 520
Cdd:PRK14072 92 YERLLEVFKAHDIGYFFYNGGndsMDTALKVSQLAKKMG-YPIRCIG---IPKTIDNDLPGTDHCPGFGSAAKyiatSVL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 521 E-SCDrikQSASGTKRRVFIVETMGGYCGYLATVTGIA-----VGADAAYVFEDPFnihdlkvNVEHMTEKMKTDIQRG- 593
Cdd:PRK14072 168 EaALD---VAAMANTSKVFILEVMGRHAGWLAAAAALAkqnpdDAPHLIYLPERPF-------DEEKFLADVRAIVKRYg 237
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 2462582655 594 --LVLRNEKCHDyytteflynlysSEGKGVFD--CRTNVLGHLQQGGA 637
Cdd:PRK14072 238 ycVVVVSEGIRD------------ADGKFIAEagLAEDAFGHAQLGGV 273
|
|
| PTZ00287 |
PTZ00287 |
6-phosphofructokinase; Provisional |
12-239 |
2.17e-05 |
|
6-phosphofructokinase; Provisional
Pssm-ID: 240345 [Multi-domain] Cd Length: 1419 Bit Score: 48.11 E-value: 2.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 12 GIYVGAKVFLIYEGYEGLVEGGENIKQANWLSVSNII-----QLGG-TIIGSARCKafTTREGRRAAAYNLVQH-GITNL 84
Cdd:PTZ00287 198 GIYDYAKRYNEQSQVIGFLGGIDGLYSKNYVTITDSLmnrfrNLGGfNMLWSGRGK--VRNKDDLIAIENIVAKlKLNGL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 85 CVIGGDGSLTGAnifrsewgSLLEELVAEGKISettartyshLNIAGLVGSIDNDFC--GTDMTIGTDSALHRIMEVIDA 162
Cdd:PTZ00287 276 VIIGGDGSNSNA--------ALISEYFAERQIP---------ISIIGIPKTIDGDLKseAIEISFGFDTATKTYSEVIGN 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 163 ITTTAQS-HQRTFVLEVMGRHCGYLALVSALASGADWLFIPEAPPEDGWE---------NFMCERlgetRSRGSRLNIII 232
Cdd:PTZ00287 339 LCTDVKTgHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGEEVEKENLSlkdivsnivNTILKR----RSLNKNYGVIL 414
|
....*..
gi 2462582655 233 IAEGAID 239
Cdd:PTZ00287 415 IPEGLIE 421
|
|
| PTZ00468 |
PTZ00468 |
phosphofructokinase family protein; Provisional |
44-239 |
3.16e-04 |
|
phosphofructokinase family protein; Provisional
Pssm-ID: 185647 [Multi-domain] Cd Length: 1328 Bit Score: 44.19 E-value: 3.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 44 VSNIIQLGG-TIIGSARCKaFTTREGRRAAAYNLVQHGITNLCVIGGDGSLTGANIfrsewgslleelvaegkISETTAR 122
Cdd:PTZ00468 160 INGILNQGGfNIICSGRHK-IETEEQMRASLEICEKLKLHGLVVIGGDDSNTNAAV-----------------LAEYFKR 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582655 123 TYSHLNIAGLVGSIDNDFCG--TDMTIGTDSALHRIMEVIDAITTTAQSHQ-RTFVLEVMGRHCGYLALVSALASGADWL 199
Cdd:PTZ00468 222 NSSSTVVVGCPKTIDGDLKNevIETSFGYDTAVKTYSEQIGSIMDAIKTEGyGYYFVRLMGRSASHITLECGLQTRANMI 301
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 2462582655 200 FIPEAPPEDGWE-----NFMCERLGETRSRGSRLNIIIIAEGAID 239
Cdd:PTZ00468 302 LIGEEIKEENRSlmsivDEIVEMILKRDSLGKKHGIVLLPEGLIE 346
|
|
| |
