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Conserved domains on  [gi|2462582704|ref|XP_054180548|]
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bromodomain and WD repeat-containing protein 1 isoform X6 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
180-499 4.09e-63

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.78  E-value: 4.09e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  180 RRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRT 259
Cdd:COG2319    114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  260 CAPVAVLQGHTGSITSLQFSPmakgSQRYMVSTGADGTVCFWQWDleslkfSPRPLKFTEKPRPGVQMLcsSFSVGGMFL 339
Cdd:COG2319    194 GKLLRTLTGHTGAVRSVAFSP----DGKLLASGSADGTVRLWDLA------TGKLLRTLTGHSGSVRSV--AFSPDGRLL 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  340 ATGSTDHVIRMYflGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILldmatriSGDLSS 419
Cdd:COG2319    262 ASGSADGTVRLW--DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-------TGHTGA 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  420 eeerfmkpkVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWDIT 499
Cdd:COG2319    333 ---------VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
180-499 4.09e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.78  E-value: 4.09e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  180 RRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRT 259
Cdd:COG2319    114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  260 CAPVAVLQGHTGSITSLQFSPmakgSQRYMVSTGADGTVCFWQWDleslkfSPRPLKFTEKPRPGVQMLcsSFSVGGMFL 339
Cdd:COG2319    194 GKLLRTLTGHTGAVRSVAFSP----DGKLLASGSADGTVRLWDLA------TGKLLRTLTGHSGSVRSV--AFSPDGRLL 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  340 ATGSTDHVIRMYflGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILldmatriSGDLSS 419
Cdd:COG2319    262 ASGSADGTVRLW--DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-------TGHTGA 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  420 eeerfmkpkVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWDIT 499
Cdd:COG2319    333 ---------VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-497 1.98e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 205.26  E-value: 1.98e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  178 MHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISD-MAVNYeNTMIAAGSCDKIIRVWC 256
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASAD-GTYLASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  257 LRTCAPVAVLQGHTGSITSLQFSPmakgSQRYMVSTGADGTVCFWQWDLESLKFSprplkFTEKPRPGvqmLCSSFSVGG 336
Cdd:cd00200     80 LETGECVRTLTGHTSYVSSVAFSP----DGRILSSSSRDKTIKVWDVETGKCLTT-----LRGHTDWV---NSVAFSPDG 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  337 MFLATGSTDHVIRMYFLgfEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWrsilldmatriSGD 416
Cdd:cd00200    148 TFVASSSQDGTIKLWDL--RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC-----------LGT 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  417 LSSEEERfmkpkVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIW 496
Cdd:cd00200    215 LRGHENG-----VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIW 288


                   .
gi 2462582704  497 D 497
Cdd:cd00200    289 D 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 359-395 2.59e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 2.59e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2462582704   359 EKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIW 395
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
180-214 1.48e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 1.48e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462582704  180 RRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS 214
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 224-309 3.53e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 3.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  224 LRGHSAEISDMAVN-YENTMIAAGSCDKIIRVWCLR--------TCAPVAVLQGHTGSITSLQFSPMakgSQRYMVSTGA 294
Cdd:PTZ00420    70 LKGHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPhndesvkeIKDPQCILKGHKKKISIIDWNPM---NYYIMCSSGF 146

                           90
                   ....*....|....*
gi 2462582704  295 DGTVCFwqWDLESLK 309
Cdd:PTZ00420   147 DSFVNI--WDIENEK 159
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
180-499 4.09e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.78  E-value: 4.09e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  180 RRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRT 259
Cdd:COG2319    114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  260 CAPVAVLQGHTGSITSLQFSPmakgSQRYMVSTGADGTVCFWQWDleslkfSPRPLKFTEKPRPGVQMLcsSFSVGGMFL 339
Cdd:COG2319    194 GKLLRTLTGHTGAVRSVAFSP----DGKLLASGSADGTVRLWDLA------TGKLLRTLTGHSGSVRSV--AFSPDGRLL 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  340 ATGSTDHVIRMYflGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILldmatriSGDLSS 419
Cdd:COG2319    262 ASGSADGTVRLW--DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-------TGHTGA 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  420 eeerfmkpkVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWDIT 499
Cdd:COG2319    333 ---------VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
180-532 3.27e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 211.69  E-value: 3.27e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  180 RRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRT 259
Cdd:COG2319     72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  260 CAPVAVLQGHTGSITSLQFSPmaKGsqRYMVSTGADGTVCFWQWDleslkfSPRPLKFTEKPRPGVQMLcsSFSVGGMFL 339
Cdd:COG2319    152 GKLLRTLTGHSGAVTSVAFSP--DG--KLLASGSDDGTVRLWDLA------TGKLLRTLTGHTGAVRSV--AFSPDGKLL 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  340 ATGSTDHVIRMYFLgfEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILldmaTRISGDLSS 419
Cdd:COG2319    220 ASGSADGTVRLWDL--ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL----TGHSGGVNS 293

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  420 eeerfmkpkvtmIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWDIT 499
Cdd:COG2319    294 ------------VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLA 360

                          330       340       350
                   ....*....|....*....|....*....|....
gi 2462582704  500 KGTKMKHYfnmiegQGH-GAVFDCKFSQDGQHFA 532
Cdd:COG2319    361 TGELLRTL------TGHtGAVTSVAFSPDGRTLA 388
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-497 1.98e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 205.26  E-value: 1.98e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  178 MHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISD-MAVNYeNTMIAAGSCDKIIRVWC 256
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDvAASAD-GTYLASGSSDKTIRLWD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  257 LRTCAPVAVLQGHTGSITSLQFSPmakgSQRYMVSTGADGTVCFWQWDLESLKFSprplkFTEKPRPGvqmLCSSFSVGG 336
Cdd:cd00200     80 LETGECVRTLTGHTSYVSSVAFSP----DGRILSSSSRDKTIKVWDVETGKCLTT-----LRGHTDWV---NSVAFSPDG 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  337 MFLATGSTDHVIRMYFLgfEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWrsilldmatriSGD 416
Cdd:cd00200    148 TFVASSSQDGTIKLWDL--RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC-----------LGT 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  417 LSSEEERfmkpkVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIW 496
Cdd:cd00200    215 LRGHENG-----VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIW 288


                   .
gi 2462582704  497 D 497
Cdd:cd00200    289 D 289
WD40 COG2319
WD40 repeat [General function prediction only];
180-532 2.56e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 183.19  E-value: 2.56e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  180 RRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRT 259
Cdd:COG2319     30 LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  260 CAPVAVLQGHTGSITSLQFSPmakgSQRYMVSTGADGTVCFwqWDLEslkfSPRPLKFTEKPRPGVQmlCSSFSVGGMFL 339
Cdd:COG2319    110 GLLLRTLTGHTGAVRSVAFSP----DGKTLASGSADGTVRL--WDLA----TGKLLRTLTGHSGAVT--SVAFSPDGKLL 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  340 ATGSTDHVIRMYFLgfEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRsilldmaTRISGDLSS 419
Cdd:COG2319    178 ASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL-------RTLTGHSGS 248

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  420 eeerfmkpkVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWDIT 499
Cdd:COG2319    249 ---------VRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLA 318

                          330       340       350
                   ....*....|....*....|....*....|....
gi 2462582704  500 KGTKMKHYfnmiegQGH-GAVFDCKFSQDGQHFA 532
Cdd:COG2319    319 TGKLLRTL------TGHtGAVRSVAFSPDGKTLA 346
WD40 COG2319
WD40 repeat [General function prediction only];
193-543 1.01e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.45  E-value: 1.01e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  193 AFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWCLRTCAPVAVLQGHTGS 272
Cdd:COG2319      1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  273 ITSLQFSPMAkgsqRYMVSTGADGTVCFWQWDleslkfSPRPLKFTEKPRPGVQMLcsSFSVGGMFLATGSTDHVIRMYf 352
Cdd:COG2319     81 VLSVAFSPDG----RLLASASADGTVRLWDLA------TGLLLRTLTGHTGAVRSV--AFSPDGKTLASGSADGTVRLW- 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  353 lGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGdlsseeerfmkpkvtmI 432
Cdd:COG2319    148 -DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS----------------V 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  433 AWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWDITKGTKMKHYfnmie 512
Cdd:COG2319    211 AFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTL----- 284

                          330       340       350
                   ....*....|....*....|....*....|..
gi 2462582704  513 gQGH-GAVFDCKFSQDGQHFACTDSHGHLLIF 543
Cdd:COG2319    285 -TGHsGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 177-396 8.19e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.41  E-value: 8.19e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  177 KMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVWC 256
Cdd:cd00200     84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  257 LRTCAPVAVLQGHTGSITSLQFSPMAKGsqryMVSTGADGTVcfWQWDLESLKFsprpLK-FTEKPRPGVQMlcsSFSVG 335
Cdd:cd00200    164 LRTGKCVATLTGHTGEVNSVAFSPDGEK----LLSSSSDGTI--KLWDLSTGKC----LGtLRGHENGVNSV---AFSPD 230

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462582704  336 GMFLATGSTDHVIRMYFLgfEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWR 396
Cdd:cd00200    231 GYLLASGSEDGTIRVWDL--RTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 359-395 2.59e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 2.59e-07
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 2462582704   359 EKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIW 395
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 259-301 2.83e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 2.83e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2462582704   259 TCAPVAVLQGHTGSITSLQFSPmakgSQRYMVSTGADGTVCFW 301
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP----DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 177-214 7.26e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 7.26e-07
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2462582704   177 KMHRRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS 214
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
180-214 1.48e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 1.48e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462582704  180 RRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWS 214
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
218-255 1.49e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 1.49e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462582704  218 GRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVW 255
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 217-255 1.53e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 1.53e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2462582704   217 NGRLLSTLRGHSAEISDMAVNYENTMIAAGSCDKIIRVW 255
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
359-395 2.32e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 2.32e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462582704  359 EKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIW 395
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
262-301 5.08e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 5.08e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462582704  262 PVAVLQGHTGSITSLQFSPmakgSQRYMVSTGADGTVCFW 301
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSP----DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 457-497 8.77e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 8.77e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2462582704   457 TGQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWD 497
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
458-497 1.31e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.31e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462582704  458 GQLLHNLMGHADEVFVLETHPfDSRIMLSAGHDGSIFIWD 497
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
180-217 2.87e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 2.87e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462582704  180 RRILGHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHN 217
Cdd:COG2319    366 RTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
PTZ00420 PTZ00420
coronin; Provisional
 224-309 3.53e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 3.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462582704  224 LRGHSAEISDMAVN-YENTMIAAGSCDKIIRVWCLR--------TCAPVAVLQGHTGSITSLQFSPMakgSQRYMVSTGA 294
Cdd:PTZ00420    70 LKGHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPhndesvkeIKDPQCILKGHKKKISIIDWNPM---NYYIMCSSGF 146

                           90
                   ....*....|....*
gi 2462582704  295 DGTVCFwqWDLESLK 309
Cdd:PTZ00420   147 DSFVNI--WDIENEK 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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