NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462583839|ref|XP_054181100|]
View 

uncharacterized protein C22orf15 isoform X4 [Homo sapiens]

Protein Classification

Il2rg and Ferritin_like domain-containing protein( domain architecture ID 11239509)

Il2rg and Ferritin_like domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Il2rg pfam15874
Putative Interleukin 2 receptor, gamma chain; This family of proteins is found in eukaryotes. ...
 7-101 1.46e-30

Putative Interleukin 2 receptor, gamma chain; This family of proteins is found in eukaryotes. Proteins in this family are typically between 137 and 197 amino acids in length.


:

Pssm-ID: 464916  Cd Length: 93  Bit Score: 107.78  E-value: 1.46e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583839   7 FGAGCSVLVNTSCRLVNLTAHLRQKAGLPPDATIALLAEDGNLVSLEEdlkegASRAQTMGNSLLKERAIYVLVRIIKG- 85
Cdd:pfam15874   1 YGDNQQFLVNPNCRVVLLLYHIKKKCGLPKEAIIDLCDETGKLKFLSL-----KPPEQDYASKLLTARGTYILVKVERGp 75

                          90
                  ....*....|....*...
gi 2462583839  86 --EDMASTRYESLLENLD 101
Cdd:pfam15874  76 trEDNSYPVYVPLLNNPE 93
Ferritin_like super family cl00264
Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Ferritin-like, ...
 78-146 2.22e-03

Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Ferritin-like, diiron-carboxylate proteins participate in a range of functions including iron regulation, mono-oxygenation, and reactive radical production. These proteins are characterized by the fact that they catalyze dioxygen-dependent oxidation-hydroxylation reactions within diiron centers; one exception is manganese catalase, which catalyzes peroxide-dependent oxidation-reduction within a dimanganese center. Diiron-carboxylate proteins are further characterized by the presence of duplicate metal ligands, glutamates and histidines (ExxH) and two additional glutamates within a four-helix bundle. Outside of these conserved residues there is little obvious homology. Members include bacterioferritin, ferritin, rubrerythrin, aromatic and alkene monooxygenase hydroxylases (AAMH), ribonucleotide reductase R2 (RNRR2), acyl-ACP-desaturases (Acyl_ACP_Desat), manganese (Mn) catalases, demethoxyubiquinone hydroxylases (DMQH), DNA protecting proteins (DPS), and ubiquinol oxidases (AOX), and the aerobic cyclase system, Fe-containing subunit (ACSF).


The actual alignment was detected with superfamily member pfam02915:

Pssm-ID: 469698  Cd Length: 137  Bit Score: 36.95  E-value: 2.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583839  78 VLVRIIKGEDMASTRYESLLENLDDHYPELAEELRRLSGLSSVGHNW-RKRMGTRRGRHEQSPTSRPRKV 146
Cdd:pfam02915   2 NLEKAIAGESSARRRYKELAEKAKNEYPQIAELFEEMAEEERRHAGFlNKLLKDLFPGLELIPLEHVRGY 71
 
Name Accession Description Interval E-value
Il2rg pfam15874
Putative Interleukin 2 receptor, gamma chain; This family of proteins is found in eukaryotes. ...
 7-101 1.46e-30

Putative Interleukin 2 receptor, gamma chain; This family of proteins is found in eukaryotes. Proteins in this family are typically between 137 and 197 amino acids in length.


Pssm-ID: 464916  Cd Length: 93  Bit Score: 107.78  E-value: 1.46e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583839   7 FGAGCSVLVNTSCRLVNLTAHLRQKAGLPPDATIALLAEDGNLVSLEEdlkegASRAQTMGNSLLKERAIYVLVRIIKG- 85
Cdd:pfam15874   1 YGDNQQFLVNPNCRVVLLLYHIKKKCGLPKEAIIDLCDETGKLKFLSL-----KPPEQDYASKLLTARGTYILVKVERGp 75

                          90
                  ....*....|....*...
gi 2462583839  86 --EDMASTRYESLLENLD 101
Cdd:pfam15874  76 trEDNSYPVYVPLLNNPE 93
Rubrerythrin pfam02915
Rubrerythrin; This domain has a ferritin-like fold.
 78-146 2.22e-03

Rubrerythrin; This domain has a ferritin-like fold.


Pssm-ID: 397180  Cd Length: 137  Bit Score: 36.95  E-value: 2.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583839  78 VLVRIIKGEDMASTRYESLLENLDDHYPELAEELRRLSGLSSVGHNW-RKRMGTRRGRHEQSPTSRPRKV 146
Cdd:pfam02915   2 NLEKAIAGESSARRRYKELAEKAKNEYPQIAELFEEMAEEERRHAGFlNKLLKDLFPGLELIPLEHVRGY 71
 
Name Accession Description Interval E-value
Il2rg pfam15874
Putative Interleukin 2 receptor, gamma chain; This family of proteins is found in eukaryotes. ...
 7-101 1.46e-30

Putative Interleukin 2 receptor, gamma chain; This family of proteins is found in eukaryotes. Proteins in this family are typically between 137 and 197 amino acids in length.


Pssm-ID: 464916  Cd Length: 93  Bit Score: 107.78  E-value: 1.46e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583839   7 FGAGCSVLVNTSCRLVNLTAHLRQKAGLPPDATIALLAEDGNLVSLEEdlkegASRAQTMGNSLLKERAIYVLVRIIKG- 85
Cdd:pfam15874   1 YGDNQQFLVNPNCRVVLLLYHIKKKCGLPKEAIIDLCDETGKLKFLSL-----KPPEQDYASKLLTARGTYILVKVERGp 75

                          90
                  ....*....|....*...
gi 2462583839  86 --EDMASTRYESLLENLD 101
Cdd:pfam15874  76 trEDNSYPVYVPLLNNPE 93
Rubrerythrin pfam02915
Rubrerythrin; This domain has a ferritin-like fold.
 78-146 2.22e-03

Rubrerythrin; This domain has a ferritin-like fold.


Pssm-ID: 397180  Cd Length: 137  Bit Score: 36.95  E-value: 2.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462583839  78 VLVRIIKGEDMASTRYESLLENLDDHYPELAEELRRLSGLSSVGHNW-RKRMGTRRGRHEQSPTSRPRKV 146
Cdd:pfam02915   2 NLEKAIAGESSARRRYKELAEKAKNEYPQIAELFEEMAEEERRHAGFlNKLLKDLFPGLELIPLEHVRGY 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH