NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462585440|ref|XP_054181878|]
View 

zinc finger protein 70 isoform X1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-442 3.43e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 3.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 138 KPYACRECGKAFSQSSHLLRHLVIHTGEKPYEC--CECGKAFSQSSHLLRHQIIHTGEKPYECR---------------- 199
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 200 ECGKAFRQSSALTQH--------QKIHTGKRPYECREC---------------------------GKDFSRSSSLRKHER 244
Cdd:COG5048   112 SSSSNSNDNNLLSSHslppssrdPQLPDLLSISNLRNNplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 245 IHTGERPYQCKECGKSFN-----------------------------------QSSGLSQHRKIHTLKKPHECDlcGKAF 289
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYsipssssdqnlensssslplttnsqlspksllsqsPSSLSSSDSSSSASESPRSSL--PTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 290 CHRSHLIRH-QRIHTGK-KPYKCDECGKAFSQSSNLIEHRKT--HTGE--KPYKC--QKCGKAFSQSSSLIEHQRIHTGE 361
Cdd:COG5048   270 SQSSSPNESdSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 362 KPYECC--QCGKAF------CHSSALIQHQRIHTGKKPYTC--ECGKAFRHRSALIEHYKTHTREKPYVCN--LCGKSFR 429
Cdd:COG5048   350 SPAKEKllNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFN 429

                         410
                  ....*....|...
gi 2462585440 430 GSSHLIRHQKIHS 442
Cdd:COG5048   430 RHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-442 3.43e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 3.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 138 KPYACRECGKAFSQSSHLLRHLVIHTGEKPYEC--CECGKAFSQSSHLLRHQIIHTGEKPYECR---------------- 199
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 200 ECGKAFRQSSALTQH--------QKIHTGKRPYECREC---------------------------GKDFSRSSSLRKHER 244
Cdd:COG5048   112 SSSSNSNDNNLLSSHslppssrdPQLPDLLSISNLRNNplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 245 IHTGERPYQCKECGKSFN-----------------------------------QSSGLSQHRKIHTLKKPHECDlcGKAF 289
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYsipssssdqnlensssslplttnsqlspksllsqsPSSLSSSDSSSSASESPRSSL--PTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 290 CHRSHLIRH-QRIHTGK-KPYKCDECGKAFSQSSNLIEHRKT--HTGE--KPYKC--QKCGKAFSQSSSLIEHQRIHTGE 361
Cdd:COG5048   270 SQSSSPNESdSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 362 KPYECC--QCGKAF------CHSSALIQHQRIHTGKKPYTC--ECGKAFRHRSALIEHYKTHTREKPYVCN--LCGKSFR 429
Cdd:COG5048   350 SPAKEKllNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFN 429

                         410
                  ....*....|...
gi 2462585440 430 GSSHLIRHQKIHS 442
Cdd:COG5048   430 RHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-319 4.89e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.89e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462585440 294 HLIRHQRIHTGKKPYKCDECGKAFSQ 319
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
138-442 3.43e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 3.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 138 KPYACRECGKAFSQSSHLLRHLVIHTGEKPYEC--CECGKAFSQSSHLLRHQIIHTGEKPYECR---------------- 199
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 200 ECGKAFRQSSALTQH--------QKIHTGKRPYECREC---------------------------GKDFSRSSSLRKHER 244
Cdd:COG5048   112 SSSSNSNDNNLLSSHslppssrdPQLPDLLSISNLRNNplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 245 IHTGERPYQCKECGKSFN-----------------------------------QSSGLSQHRKIHTLKKPHECDlcGKAF 289
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYsipssssdqnlensssslplttnsqlspksllsqsPSSLSSSDSSSSASESPRSSL--PTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 290 CHRSHLIRH-QRIHTGK-KPYKCDECGKAFSQSSNLIEHRKT--HTGE--KPYKC--QKCGKAFSQSSSLIEHQRIHTGE 361
Cdd:COG5048   270 SQSSSPNESdSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 362 KPYECC--QCGKAF------CHSSALIQHQRIHTGKKPYTC--ECGKAFRHRSALIEHYKTHTREKPYVCN--LCGKSFR 429
Cdd:COG5048   350 SPAKEKllNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFN 429

                         410
                  ....*....|...
gi 2462585440 430 GSSHLIRHQKIHS 442
Cdd:COG5048   430 RHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-437 1.52e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 171 CECGKAFSQSSHLLRHQIIHTGEKPYECRECGKAFRQSSALTqHQKIHTGKRPYECRECGKDFSRSSSLRKHERIHTGER 250
Cdd:COG5048   175 SLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSS-DQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDS 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 251 PYQCKECGKSFNQSSGLSQHRKIHTL-------KKPHECDLCGKAFCHRSHLIRHQR--IHTGK--KPYKCDE--CGKAF 317
Cdd:COG5048   254 SSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLF 333

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 318 SQSSNLIEHRKTHTGEKPYKC--QKCGKAFSQSS-----SLIEHQRIHTGEKPYECC-QCGKAFCHSSALIQHQRI-HTG 388
Cdd:COG5048   334 SRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsNSCIRNFKRDSNLSLHIItHLS 413

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462585440 389 KKPYTCE---CGKAFRHRSALIEHYKTHTREKPYVCNLCgKSFRGSSHLIRH 437
Cdd:COG5048   414 FRPYNCKnppCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-446 1.13e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 166 KPYECCECGKAFSQSSHLLRHQIIHTGEKPYECR--ECGKAFRQSSALTQHQKIHTGKRPYECRECGKDFSRSSSLRKHE 243
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 244 RIHTgERPYQCKECGKSFNQSSGLSQHRKIHTLKKPHECDLcgkafcHRSHLIRHQRIHTGKKPYKCD---ECGKAFSQS 320
Cdd:COG5048   112 SSSS-NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPL------PGNNSSSVNTPQSNSLHPPLPansLSKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 321 SNLIEHRKTHTGEKPYKCQKCGKAFSQSSSLIEHQRIH-TGEKPYECCQCGKAfCHSSALIQHQRIHTGKKPYTCEC--- 396
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSP-KSLLSQSPSSLSSSDSSSSASESprs 263

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462585440 397 --GKAFRHRSALIEHY--KTHTREKPYVCNLCGKSFRGSSHLIRHQ--KIHSGEKL 446
Cdd:COG5048   264 slPTASSQSSSPNESDssSEKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGESL 319
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
277-350 9.32e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 9.32e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462585440 277 KKPHECDLCGKAFCHRSHLIRHQRIHTGKKPYKC--DECGKAFSQSSNLIEHRKTHTGEKPYKCQKCGKAFSQSSS 350
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS 106
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-319 4.89e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.89e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462585440 294 HLIRHQRIHTGKKPYKCDECGKAFSQ 319
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
238-263 6.19e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 6.19e-05
                          10        20
                  ....*....|....*....|....*.
gi 2462585440 238 SLRKHERIHTGERPYQCKECGKSFNQ 263
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
305-371 8.21e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 8.21e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462585440 305 KKPYKCDECGKAFSQSSNLIEHRKTHTGEKPYKC--QKCGKAFSQSSSLIEHQRIHTGEKPYECCQCGK 371
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 248-331 1.73e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 248 GERPYQCK--ECGKSFNQSSGLSQHRKI-HTLKKPHEcdlcgkafchRSHLIRHQRIHTGKKPYKCDECGKAFSQSSNLI 324
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHE----------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 2462585440 325 EHRKTHT 331
Cdd:COG5189   416 YHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
322-347 3.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.34e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462585440 322 NLIEHRKTHTGEKPYKCQKCGKAFSQ 347
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
182-207 3.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.44e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462585440 182 HLLRHQIIHTGEKPYECRECGKAFRQ 207
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 192-276 4.64e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 4.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 192 GEKPYECR--ECGKAFRQSSALTQHqKIHTgkrpyecrECGKDFSRSSSLRKHERIHTGERPYQCKECGKSFNQSSGLSQ 269
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*..
gi 2462585440 270 HRKIHTL 276
Cdd:COG5189   417 HRKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-235 1.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.46e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462585440 210 ALTQHQKIHTGKRPYECRECGKDFSR 235
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 308-330 2.86e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.86e-03
                          10        20
                  ....*....|....*....|...
gi 2462585440 308 YKCDECGKAFSQSSNLIEHRKTH 330
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 280-302 4.28e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.28e-03
                          10        20
                  ....*....|....*....|...
gi 2462585440 280 HECDLCGKAFCHRSHLIRHQRIH 302
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 336-358 4.86e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 4.86e-03
                          10        20
                  ....*....|....*....|...
gi 2462585440 336 YKCQKCGKAFSQSSSLIEHQRIH 358
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
154-179 5.27e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.27e-03
                          10        20
                  ....*....|....*....|....*.
gi 2462585440 154 HLLRHLVIHTGEKPYECCECGKAFSQ 179
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 360-442 5.35e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 5.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 360 GEKPYEC--CQCGKAFCHSSALIQHqRIHTGKKPYTCECGKAFRHRSALIEhykthtrEKPYVCNLCGKSFRGSSHLIRH 437
Cdd:COG5189   346 DGKPYKCpvEGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPEKMNIFSAK-------DKPYRCEVCDKRYKNLNGLKYH 417


                  ....*
gi 2462585440 438 QKiHS 442
Cdd:COG5189   418 RK-HS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 419-441 6.03e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.03e-03
                          10        20
                  ....*....|....*....|...
gi 2462585440 419 YVCNLCGKSFRGSSHLIRHQKIH 441
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-442 8.61e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.52  E-value: 8.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 221 KRPYECRECGKDFSRSSSLRKHERIHTGERPYQC--KECGKSFNQSSGLSQHRKIHTLKKPHEC-DLCGKAFCHRSHLIR 297
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585440 298 HQRIHTGKKPYKCDECGKAFSQSSNLIEHRKTHTGEKPYKCQKCGKAF--SQSSSLIEHQRIHTgekpyecCQCGKAFCH 375
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvnTPQSNSLHPPLPAN-------SLSKDPSSN 183

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462585440 376 SSALIQHQRIHTGKKPYTCECGKAFRHRSALIEHYKTHTREKPYVCNLCGKSFRGSSHLIRHQKIHS 442
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS 250
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH