|
Name |
Accession |
Description |
Interval |
E-value |
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
376-516 |
8.55e-31 |
|
Clathrin heavy chain repeat homology;
:
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 118.15 E-value: 8.55e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 376 LSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYISR-LDNYDALDIAS 454
Cdd:smart00299 1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLDNkSNHYDIEKVGK 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 455 IAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKD 516
Cdd:smart00299 78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDKP 139
|
|
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
83-221 |
1.91e-30 |
|
Clathrin heavy chain repeat homology;
:
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 116.99 E-value: 1.91e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 83 ASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNF-SQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLK 161
Cdd:smart00299 1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462585579 162 EAKLTDQLPLIIVCDRFgFVHDLVLYLYR-NNLQRYIEIYVQKVNPSRTPAVIGGLLDVDC 221
Cdd:smart00299 81 KAKLYEEAVELYKKDGN-FKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
|
|
| Clathrin |
pfam00637 |
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ... |
824-961 |
9.90e-29 |
|
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.
:
Pssm-ID: 459884 [Multi-domain] Cd Length: 142 Bit Score: 112.35 E-value: 9.90e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 824 SPRLDHTWTVSFFSKAGQLPLVKPYLRSVQ---SHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNISLAQQLEKHQ 900
Cdd:pfam00637 5 TDPIDVSRVVKLFEKAGLLEELISYLESALkedSRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462585579 901 LMEFRCiaaYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQKLLQWFLEEGKRE 961
Cdd:pfam00637 85 LYEEAV---ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
|
|
| Clathrin |
pfam00637 |
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ... |
525-664 |
6.88e-28 |
|
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.
:
Pssm-ID: 459884 [Multi-domain] Cd Length: 142 Bit Score: 110.04 E-value: 6.88e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 525 YIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRE--SYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRC 602
Cdd:pfam00637 1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 603 YEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFR 664
Cdd:pfam00637 81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
|
|
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
671-813 |
6.81e-27 |
|
Clathrin heavy chain repeat homology;
:
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 106.97 E-value: 6.81e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 671 LHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGVFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAE 750
Cdd:smart00299 1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462585579 751 QAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAwkeGQFKDIITKVANVELCYRALQFYLDYKP 813
Cdd:smart00299 81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
|
|
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
230-357 |
1.63e-25 |
|
Clathrin heavy chain repeat homology;
:
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 103.12 E-value: 1.63e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 230 IMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSP--ECFLRENAYYDSSVVGRYCE 307
Cdd:smart00299 1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 308 KRDPH-LACVAYERGQCDLELIKVCNENS-LFKSEARYLVCRKDPELWAHVL 357
Cdd:smart00299 81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVL 132
|
|
| CLH super family |
cl46917 |
Clathrin heavy chain repeat homology; |
1-71 |
1.13e-12 |
|
Clathrin heavy chain repeat homology;
The actual alignment was detected with superfamily member smart00299:
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 66.14 E-value: 1.13e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462585579 1 MFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHT--HLLNPEWLVNFFGS-LSVEDSVECLHAMLSAN 71
Cdd:smart00299 66 KSNHYDIEKVGKLCEKAKLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
376-516 |
8.55e-31 |
|
Clathrin heavy chain repeat homology;
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 118.15 E-value: 8.55e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 376 LSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYISR-LDNYDALDIAS 454
Cdd:smart00299 1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLDNkSNHYDIEKVGK 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 455 IAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKD 516
Cdd:smart00299 78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDKP 139
|
|
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
83-221 |
1.91e-30 |
|
Clathrin heavy chain repeat homology;
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 116.99 E-value: 1.91e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 83 ASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNF-SQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLK 161
Cdd:smart00299 1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462585579 162 EAKLTDQLPLIIVCDRFgFVHDLVLYLYR-NNLQRYIEIYVQKVNPSRTPAVIGGLLDVDC 221
Cdd:smart00299 81 KAKLYEEAVELYKKDGN-FKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
|
|
| Clathrin |
pfam00637 |
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ... |
824-961 |
9.90e-29 |
|
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.
Pssm-ID: 459884 [Multi-domain] Cd Length: 142 Bit Score: 112.35 E-value: 9.90e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 824 SPRLDHTWTVSFFSKAGQLPLVKPYLRSVQ---SHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNISLAQQLEKHQ 900
Cdd:pfam00637 5 TDPIDVSRVVKLFEKAGLLEELISYLESALkedSRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462585579 901 LMEFRCiaaYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQKLLQWFLEEGKRE 961
Cdd:pfam00637 85 LYEEAV---ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
|
|
| Clathrin |
pfam00637 |
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ... |
376-516 |
2.11e-28 |
|
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.
Pssm-ID: 459884 [Multi-domain] Cd Length: 142 Bit Score: 111.19 E-value: 2.11e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 376 LSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSvfSEHRNLQNLLILTAIKADR-TRVMEYISRLDNYDALDIAS 454
Cdd:pfam00637 1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 455 IAVSSALYEEAFTVFHKFDMNASAIqVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKD 516
Cdd:pfam00637 79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
|
|
| Clathrin |
pfam00637 |
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ... |
525-664 |
6.88e-28 |
|
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.
Pssm-ID: 459884 [Multi-domain] Cd Length: 142 Bit Score: 110.04 E-value: 6.88e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 525 YIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRE--SYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRC 602
Cdd:pfam00637 1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 603 YEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFR 664
Cdd:pfam00637 81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
|
|
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
525-662 |
1.40e-27 |
|
Clathrin heavy chain repeat homology;
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 108.90 E-value: 1.40e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 525 YIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRE-SYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCY 603
Cdd:smart00299 1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 604 EEGMYEAAKLLYSNVSNFARLASTLV-HLGEYQAAVDNSRKASSTRTWKEVCFACMDGQE 662
Cdd:smart00299 81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
|
|
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
671-813 |
6.81e-27 |
|
Clathrin heavy chain repeat homology;
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 106.97 E-value: 6.81e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 671 LHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGVFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAE 750
Cdd:smart00299 1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462585579 751 QAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAwkeGQFKDIITKVANVELCYRALQFYLDYKP 813
Cdd:smart00299 81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
|
|
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
824-975 |
3.90e-26 |
|
Clathrin heavy chain repeat homology;
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 104.66 E-value: 3.90e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 824 SPRLDHTWTVSFFSKAGQLPLVKPYLRSVQSHNnkSVNEALNHLLTEEEDYQGLRASIDAYDNFdnislaqqlekHQLME 903
Cdd:smart00299 5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN--SENPALQTKLIELYAKYDPQKEIERLDNK-----------SNHYD 71
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 904 FRCIAAYLYKGNNwWAQSVELCKKDHLYKDAMQHAAEsrDAELAQKLLQWFLEEGKRECFAACLFTCYDLLR 975
Cdd:smart00299 72 IEKVGKLCEKAKL-YEEAVELYKKDGNFKDAIVTLIE--HLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
|
|
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
230-357 |
1.63e-25 |
|
Clathrin heavy chain repeat homology;
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 103.12 E-value: 1.63e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 230 IMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSP--ECFLRENAYYDSSVVGRYCE 307
Cdd:smart00299 1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 308 KRDPH-LACVAYERGQCDLELIKVCNENS-LFKSEARYLVCRKDPELWAHVL 357
Cdd:smart00299 81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVL 132
|
|
| Clathrin |
pfam00637 |
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ... |
85-223 |
1.54e-23 |
|
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.
Pssm-ID: 459884 [Multi-domain] Cd Length: 142 Bit Score: 97.33 E-value: 1.54e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 85 KYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFS--QDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKE 162
Cdd:pfam00637 3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEK 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 163 AKLTDQLPLIIVCdrFGFVHDLV-LYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSE 223
Cdd:pfam00637 83 ADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
|
|
| Clathrin |
pfam00637 |
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ... |
240-367 |
4.51e-23 |
|
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.
Pssm-ID: 459884 [Multi-domain] Cd Length: 142 Bit Score: 96.17 E-value: 4.51e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 240 DELVAEVEKRNRLKLLLPWLESQIQEG-CEEPATHNALAKIYIDSN--NSPECFLRENAYYDSSVVGRYCEKRDPH-LAC 315
Cdd:pfam00637 11 SRVVKLFEKAGLLEELISYLESALKEDsRENPALQTALIELYAKYDdpEELEEFLKKNNNYDLEKVAKLCEKADLYeEAV 90
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 316 VAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQL 367
Cdd:pfam00637 91 ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
|
|
| Clathrin |
pfam00637 |
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ... |
671-813 |
5.47e-18 |
|
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.
Pssm-ID: 459884 [Multi-domain] Cd Length: 142 Bit Score: 81.53 E-value: 5.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 671 LHIVIHADELEELMCYYQDRGYFEELILL-LEAALGLERAHMGVFTELAILYSKF-KPQKMLEHLELFWSrVNIPKVLRA 748
Cdd:pfam00637 1 LIESTDPIDVSRVVKLFEKAGLLEELISYlESALKEDSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462585579 749 AEQAHLWAELVFLYDKYEEYDNAVltMMSHPTEAWKEGQfkDIITKVANVELCYRALQFYLDYKP 813
Cdd:pfam00637 80 CEKADLYEEAVILYKKIGNWKEAI--SLLKKLGDYKDAI--EYAVKSSNPELWEELLEALLDNGR 140
|
|
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
1-71 |
1.13e-12 |
|
Clathrin heavy chain repeat homology;
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 66.14 E-value: 1.13e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462585579 1 MFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHT--HLLNPEWLVNFFGS-LSVEDSVECLHAMLSAN 71
Cdd:smart00299 66 KSNHYDIEKVGKLCEKAKLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
|
|
| Clathrin |
pfam00637 |
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ... |
1-75 |
2.93e-09 |
|
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.
Pssm-ID: 459884 [Multi-domain] Cd Length: 142 Bit Score: 56.50 E-value: 2.93e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462585579 1 MFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAV-VHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQN 75
Cdd:pfam00637 67 KNNNYDLEKVAKLCEKADLYEEAVILYKKIGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
|
|
| Coatomer_WDAD_beta-like |
cd22947 |
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ... |
461-562 |
6.64e-05 |
|
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.
Pssm-ID: 438572 Cd Length: 475 Bit Score: 46.69 E-value: 6.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 461 LYEEAFTVF----HKFDMnasAIQvliehIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLE 536
Cdd:cd22947 327 LKELALEVStdpdHKFEL---ALQ-----LGDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGDLSGLLL 398
|
90 100
....*....|....*....|....*.
gi 2462585579 537 VvqsASRSNNWEDLVKFLQMARKKGR 562
Cdd:cd22947 399 L---YSSTGDKEGLEELAELAEAAGK 421
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
376-516 |
8.55e-31 |
|
Clathrin heavy chain repeat homology;
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 118.15 E-value: 8.55e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 376 LSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSvfsEHRNLQNLLILTAIKADRTRVMEYISR-LDNYDALDIAS 454
Cdd:smart00299 1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNS---ENPALQTKLIELYAKYDPQKEIERLDNkSNHYDIEKVGK 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 455 IAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKD 516
Cdd:smart00299 78 LCEKAKLYEEAVELYKKDGNFKDAIVTLIEHLGNYEKAIEYFVKQNNPELWAEVLKALLDKP 139
|
|
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
83-221 |
1.91e-30 |
|
Clathrin heavy chain repeat homology;
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 116.99 E-value: 1.91e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 83 ASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNF-SQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLK 161
Cdd:smart00299 1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLnSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462585579 162 EAKLTDQLPLIIVCDRFgFVHDLVLYLYR-NNLQRYIEIYVQKVNPSRTPAVIGGLLDVDC 221
Cdd:smart00299 81 KAKLYEEAVELYKKDGN-FKDAIVTLIEHlGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
|
|
| Clathrin |
pfam00637 |
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ... |
824-961 |
9.90e-29 |
|
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.
Pssm-ID: 459884 [Multi-domain] Cd Length: 142 Bit Score: 112.35 E-value: 9.90e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 824 SPRLDHTWTVSFFSKAGQLPLVKPYLRSVQ---SHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNISLAQQLEKHQ 900
Cdd:pfam00637 5 TDPIDVSRVVKLFEKAGLLEELISYLESALkedSRENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEKAD 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462585579 901 LMEFRCiaaYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQKLLQWFLEEGKRE 961
Cdd:pfam00637 85 LYEEAV---ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
|
|
| Clathrin |
pfam00637 |
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ... |
376-516 |
2.11e-28 |
|
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.
Pssm-ID: 459884 [Multi-domain] Cd Length: 142 Bit Score: 111.19 E-value: 2.11e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 376 LSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSvfSEHRNLQNLLILTAIKADR-TRVMEYISRLDNYDALDIAS 454
Cdd:pfam00637 1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDS--RENPALQTALIELYAKYDDpEELEEFLKKNNNYDLEKVAK 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 455 IAVSSALYEEAFTVFHKFDMNASAIqVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKD 516
Cdd:pfam00637 79 LCEKADLYEEAVILYKKIGNWKEAI-SLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNG 139
|
|
| Clathrin |
pfam00637 |
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ... |
525-664 |
6.88e-28 |
|
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.
Pssm-ID: 459884 [Multi-domain] Cd Length: 142 Bit Score: 110.04 E-value: 6.88e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 525 YIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRE--SYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRC 602
Cdd:pfam00637 1 LIESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDSRenPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLC 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 603 YEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFR 664
Cdd:pfam00637 81 EKADLYEEAVILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
|
|
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
525-662 |
1.40e-27 |
|
Clathrin heavy chain repeat homology;
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 108.90 E-value: 1.40e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 525 YIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRE-SYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCY 603
Cdd:smart00299 1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSEnPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 604 EEGMYEAAKLLYSNVSNFARLASTLV-HLGEYQAAVDNSRKASSTRTWKEVCFACMDGQE 662
Cdd:smart00299 81 KAKLYEEAVELYKKDGNFKDAIVTLIeHLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
|
|
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
671-813 |
6.81e-27 |
|
Clathrin heavy chain repeat homology;
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 106.97 E-value: 6.81e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 671 LHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGVFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAE 750
Cdd:smart00299 1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKEIERLDNKSNHYDIEKVGKLCE 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462585579 751 QAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAwkeGQFKDIITKVANVELCYRALQFYLDYKP 813
Cdd:smart00299 81 KAKLYEEAVELYKKDGNFKDAIVTLIEHLGNY---EKAIEYFVKQNNPELWAEVLKALLDKPR 140
|
|
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
824-975 |
3.90e-26 |
|
Clathrin heavy chain repeat homology;
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 104.66 E-value: 3.90e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 824 SPRLDHTWTVSFFSKAGQLPLVKPYLRSVQSHNnkSVNEALNHLLTEEEDYQGLRASIDAYDNFdnislaqqlekHQLME 903
Cdd:smart00299 5 SDPIDVSEVVELFEKRNLLEELIPYLESALKLN--SENPALQTKLIELYAKYDPQKEIERLDNK-----------SNHYD 71
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 904 FRCIAAYLYKGNNwWAQSVELCKKDHLYKDAMQHAAEsrDAELAQKLLQWFLEEGKRECFAACLFTCYDLLR 975
Cdd:smart00299 72 IEKVGKLCEKAKL-YEEAVELYKKDGNFKDAIVTLIE--HLGNYEKAIEYFVKQNNPELWAEVLKALLDKPR 140
|
|
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
230-357 |
1.63e-25 |
|
Clathrin heavy chain repeat homology;
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 103.12 E-value: 1.63e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 230 IMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSP--ECFLRENAYYDSSVVGRYCE 307
Cdd:smart00299 1 LLEVSDPIDVSEVVELFEKRNLLEELIPYLESALKLNSENPALQTKLIELYAKYDPQKeiERLDNKSNHYDIEKVGKLCE 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 308 KRDPH-LACVAYERGQCDLELIKVCNENS-LFKSEARYLVCRKDPELWAHVL 357
Cdd:smart00299 81 KAKLYeEAVELYKKDGNFKDAIVTLIEHLgNYEKAIEYFVKQNNPELWAEVL 132
|
|
| Clathrin |
pfam00637 |
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ... |
85-223 |
1.54e-23 |
|
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.
Pssm-ID: 459884 [Multi-domain] Cd Length: 142 Bit Score: 97.33 E-value: 1.54e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 85 KYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFS--QDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKE 162
Cdd:pfam00637 3 ESTDPIDVSRVVKLFEKAGLLEELISYLESALKEDsrENPALQTALIELYAKYDDPEELEEFLKKNNNYDLEKVAKLCEK 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 163 AKLTDQLPLIIVCdrFGFVHDLV-LYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSE 223
Cdd:pfam00637 83 ADLYEEAVILYKK--IGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
|
|
| Clathrin |
pfam00637 |
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ... |
240-367 |
4.51e-23 |
|
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.
Pssm-ID: 459884 [Multi-domain] Cd Length: 142 Bit Score: 96.17 E-value: 4.51e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 240 DELVAEVEKRNRLKLLLPWLESQIQEG-CEEPATHNALAKIYIDSN--NSPECFLRENAYYDSSVVGRYCEKRDPH-LAC 315
Cdd:pfam00637 11 SRVVKLFEKAGLLEELISYLESALKEDsRENPALQTALIELYAKYDdpEELEEFLKKNNNYDLEKVAKLCEKADLYeEAV 90
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 2462585579 316 VAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQL 367
Cdd:pfam00637 91 ILYKKIGNWKEAISLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
|
|
| Clathrin |
pfam00637 |
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ... |
671-813 |
5.47e-18 |
|
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.
Pssm-ID: 459884 [Multi-domain] Cd Length: 142 Bit Score: 81.53 E-value: 5.47e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 671 LHIVIHADELEELMCYYQDRGYFEELILL-LEAALGLERAHMGVFTELAILYSKF-KPQKMLEHLELFWSrVNIPKVLRA 748
Cdd:pfam00637 1 LIESTDPIDVSRVVKLFEKAGLLEELISYlESALKEDSRENPALQTALIELYAKYdDPEELEEFLKKNNN-YDLEKVAKL 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462585579 749 AEQAHLWAELVFLYDKYEEYDNAVltMMSHPTEAWKEGQfkDIITKVANVELCYRALQFYLDYKP 813
Cdd:pfam00637 80 CEKADLYEEAVILYKKIGNWKEAI--SLLKKLGDYKDAI--EYAVKSSNPELWEELLEALLDNGR 140
|
|
| CLH |
smart00299 |
Clathrin heavy chain repeat homology; |
1-71 |
1.13e-12 |
|
Clathrin heavy chain repeat homology;
Pssm-ID: 128594 [Multi-domain] Cd Length: 140 Bit Score: 66.14 E-value: 1.13e-12
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462585579 1 MFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHT--HLLNPEWLVNFFGS-LSVEDSVECLHAMLSAN 71
Cdd:smart00299 66 KSNHYDIEKVGKLCEKAKLYEEAVELYKKDGNFKDAIVTLieHLGNYEKAIEYFVKqNNPELWAEVLKALLDKP 139
|
|
| Clathrin |
pfam00637 |
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ... |
1-75 |
2.93e-09 |
|
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.
Pssm-ID: 459884 [Multi-domain] Cd Length: 142 Bit Score: 56.50 E-value: 2.93e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462585579 1 MFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAV-VHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQN 75
Cdd:pfam00637 67 KNNNYDLEKVAKLCEKADLYEEAVILYKKIGNWKEAIsLLKKLGDYKDAIEYAVKSSNPELWEELLEALLDNGRFE 142
|
|
| Coatomer_WDAD |
pfam04053 |
Coatomer WD associated region; This region is composed of WD40 repeats. |
470-564 |
5.62e-05 |
|
Coatomer WD associated region; This region is composed of WD40 repeats.
Pssm-ID: 427679 Cd Length: 439 Bit Score: 46.84 E-value: 5.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 470 HKFDMnasAIQvliehIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPS--SYLevvqsASRSNNW 547
Cdd:pfam04053 319 TRFDL---ALE-----LGNLDVALEIAKELDDPAKWKRLGDAALSQGNIKLAEEAYQKAKDFDklLLL-----YLSTGNM 385
|
90
....*....|....*..
gi 2462585579 548 EDLVKFLQMARKKGRES 564
Cdd:pfam04053 386 EKLKKLAKIAEKRGDYN 402
|
|
| Coatomer_WDAD_beta-like |
cd22947 |
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ... |
461-562 |
6.64e-05 |
|
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.
Pssm-ID: 438572 Cd Length: 475 Bit Score: 46.69 E-value: 6.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462585579 461 LYEEAFTVF----HKFDMnasAIQvliehIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLE 536
Cdd:cd22947 327 LKELALEVStdpdHKFEL---ALQ-----LGDLDLALEIARESESESKWKQLGDLALSKGDFDLAEECLKKAGDLSGLLL 398
|
90 100
....*....|....*....|....*.
gi 2462585579 537 VvqsASRSNNWEDLVKFLQMARKKGR 562
Cdd:cd22947 399 L---YSSTGDKEGLEELAELAEAAGK 421
|
|
| |
