|
Name |
Accession |
Description |
Interval |
E-value |
| HECTc |
cd00078 |
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ... |
4102-4455 |
4.26e-161 |
|
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.
:
Pssm-ID: 238033 [Multi-domain] Cd Length: 352 Bit Score: 502.48 E-value: 4.26e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4102 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH 4181
Cdd:cd00078 3 ITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDSGLLYPNPSSF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4182 CNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEV 4261
Cdd:cd00078 83 ADEDHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGDEDDLELTFTIEL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4262 QE-FGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTI 4340
Cdd:cd00078 163 DSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICGSEDI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4341 DIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEgmngiQKFQIHRDDRSTDRLP 4419
Cdd:cd00078 243 DLEDLKKNTEYkGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLN-----PKFTIRRVGSPDDRLP 317
|
330 340 350
....*....|....*....|....*....|....*.
gi 2462627860 4420 SAHTCFNQLDLPAYESFEKLRHMLLLAIQECsEGFG 4455
Cdd:cd00078 318 TAHTCFNLLKLPPYSSKEILREKLLYAINEG-AGFG 352
|
|
| DUF913 |
pfam06025 |
Domain of Unknown Function (DUF913); Members of this family are found in various ubiquitin ... |
431-897 |
1.16e-95 |
|
Domain of Unknown Function (DUF913); Members of this family are found in various ubiquitin protein ligases.
:
Pssm-ID: 461803 Cd Length: 369 Bit Score: 315.32 E-value: 1.16e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 431 RAVRVVD-LITNLD--MAAFQSHSGLSIFIYRLEHEVDLCRKECpfvikpkiqrpnttQEGEEMETDMdvadvamessPG 507
Cdd:pfam06025 1 RAVQFLDtLIYNFQdaFQAFRNAGGLDAIIDRIVHEVDSALELA--------------EAGKGTPSEY----------KS 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 508 SSISMEhrldvelrasgsssstnissgpspgpspgpgtgpgpgpgpgpgpgpgpgpgpgpgpgpgpgpgprpgvqcIP-Q 586
Cdd:pfam06025 57 SVVDYE----------------------------------------------------------------------IPyY 66
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 587 RAALLKSMLNFLKKAIQ--DPAFSDGIRHVMDGS-LPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNG 663
Cdd:pfam06025 67 RQQLLKWLLKFIHHMMQhsGGGTDRLLRNLIDSSqLLGSLRKIIENAKVFGSSVWSLAVNILSDFIHNEPTSFAVIQEAG 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 664 LTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRrrrssdPLGDTASNLG 743
Cdd:pfam06025 147 LSKAFLEAVLAKGILPSSEAINSIPNAFGAICLNNAGLELFKSSNALESFFEIFESPDHVKAME------TDGELASNLG 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 744 SAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDP--------KYICQKPSIQKADGTATAPPPRSNHAAEEASSEDEEE 815
Cdd:pfam06025 221 SSFDELVRHHPSLKPAIINAVIDMLARVVELGSTKaepdgwgaKLWVGCSSSSSFSPASSGSLPMETDGESGDESSSDED 300
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 816 EEVQAMQSFNSTQQNETEPNQQvvgteeripiPLMDYILNVMKFVESILSNNTtddHCQEFVNQKGLLPLVTILGLPNLP 895
Cdd:pfam06025 301 VEMEDAPDTDSTEETEPESHGN----------SLTDYIDNVARFLEAFFSNNS---HCSDFIEKGGIELLLDLATLPSLP 367
|
..
gi 2462627860 896 ID 897
Cdd:pfam06025 368 YD 369
|
|
| DUF908 super family |
cl20318 |
Domain of Unknown Function (DUF908); |
92-367 |
7.75e-24 |
|
Domain of Unknown Function (DUF908);
The actual alignment was detected with superfamily member pfam06012:
Pssm-ID: 428721 Cd Length: 351 Bit Score: 106.26 E-value: 7.75e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 92 LLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKR-SNYITRLGSDKRTP-----------L 159
Cdd:pfam06012 5 LVEAILRFTRLLLENCGNRSIYNSSEHLNDLLNTTSLDVLLAALRLLLRLAQRySASNSRRGSAPRHIqqsllanhyniD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 160 LTRLQHLAESWG------------------GKENGFGLAECCRDLHmmKYPPS-ATTLHFEFYADPGAEVKIEK------ 214
Cdd:pfam06012 85 LDRLLKLAQPFPkppppdstdpapsttknsANEYANDLVSLAKEDS--KVLPSeWGSVKFTYYPSSSSDEAPTSskssts 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 215 -----------------------------------RTTSNTLHYIHIEQLDKISESPSEIMESLtkMYSIPKDKQMLLFT 259
Cdd:pfam06012 163 snsspstptplrrsstlgtspdspsspststpssaADSDEGLRTFEIPESKVASKSLEDILAKA--IEDLPKESRFELLH 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 260 HIRLAHGFSNHR--KRLQAVQARLHAISILVYSNALQESANSILY--NGLIEELVDVLQITDKQLMEIKAASLRTLTSIV 335
Cdd:pfam06012 241 RIRIAKALNSSSeeSRQQLLAIRLLAIANLAYIHPESTFQTKLFEydPDLVYQLAELIHPDTEVPLELQTAALYALEALA 320
|
330 340 350
....*....|....*....|....*....|..
gi 2462627860 336 HleRTPKLSSIIDCTGTASYHGFLPVLVRNCI 367
Cdd:pfam06012 321 R--HRAKLSDVLSALGANVNHGILLYVLRKAV 350
|
|
| UBA_HUWE1 |
cd14288 |
UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins; HUWE1, ... |
1400-1439 |
6.06e-15 |
|
UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins; HUWE1, also called ARF-binding protein 1 (ARF-BP1), HECT, UBA and WWE domain-containing protein 1, homologous to E6AP carboxyl terminus homologs protein 9 (HectH9), large structure of UREB1 (LASU1), Mcl-1 ubiquitin ligase E3 (Mule), upstream regulatory element-binding protein 1 (URE-B1), or URE-binding protein 1, may function as a ubiquitin-protein ligase that involves in the ubiquitination cascade that targets specific substrate proteins in proteolysis. It can ubiquitylate DNA polymerase beta (Pol beta), the major BER DNA polymerase and modulates base excision repair (BER). HUWE1 also acts as a critical mediator of both the p53-independent and p53-dependent tumor suppressor functions of ARF tumor suppressor in p53 regulation. Moreover, HUWE1 is both required and sufficient for the polyubiquitination of Mcl-1, an anti-apoptotic Bcl-2 family member involving in DNA damage-induced apoptosis. Furthermore, HUWE1 plays an important role in the regulation of Cdc6 stability after DNA damage. In addition, HUWE1 works as a partner of N-Myc oncoprotein in neural cells. It ubiquitinates N-Myc and primes it for proteasomal-mediated degradation. HUWE1 contains a ubiquitin-associated (UBA) domain, a WWE domain, and a Bcl-2 homology region 3 (BH3) domain at the N-terminus and a HECT domain at the C-terminus. WWE domain plays a role in the regulation of specific protein-protein interactions in a ubiquitin conjugation system. BH3 domain is responsible for the specific binding to Mcl-1. HECT domain involves in the inhibition of the transcriptional activity of p53 via a ubiquitin-dependent degradation pathway. It also controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
:
Pssm-ID: 270474 Cd Length: 40 Bit Score: 71.28 E-value: 6.06e-15
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2462627860 1400 VNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHP 1439
Cdd:cd14288 1 VNEAHLQQLMDMGFTREHALEALLHTSTLEQATEYLLTHP 40
|
|
| WWE |
pfam02825 |
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to ... |
1700-1761 |
4.54e-14 |
|
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems.
:
Pssm-ID: 460715 [Multi-domain] Cd Length: 66 Bit Score: 69.63 E-value: 4.54e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462627860 1700 WRWFDDRsGRWCSYSASNNSTIDSAWKSGETSV--RFTAGRRRYTVQFTTMVQVNEETGNRRPV 1761
Cdd:pfam02825 2 WEWEDDN-GGWHPYDPEVSSLIEEAYQKGKPSVdlSITTAGFPYTIDFKSMTQTNKDTGTTRPV 64
|
|
| UBM |
pfam14377 |
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT ... |
3093-3126 |
1.08e-07 |
|
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and Arabidopsis UPL1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM).
:
Pssm-ID: 464159 [Multi-domain] Cd Length: 34 Bit Score: 50.58 E-value: 1.08e-07
10 20 30
....*....|....*....|....*....|....
gi 2462627860 3093 GNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQR 3126
Cdd:pfam14377 1 AAPPPEGIDPSFLAALPPDLRQEVLAQQDDERLR 34
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
2818-3149 |
1.77e-06 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.94 E-value: 1.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2818 SDGTPMPDSYPTTPSSTDAAtSESKETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGeggSSTQLLMPVEPEELGPTRP 2897
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDP-APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVG---SLTSLADPPPPPPTPEPAP 2712
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2898 SGEAETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASctleeavgdTSAAGSSEQPRAgsstPGDAP 2977
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT---------TAGPPAPAPPAA----PAAGP 2779
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2978 PAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSRGileEPLPSTSSEEEDPLAGISLPEGVDPSFLA 3057
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP---LPPPTSAQPTAPPPPPGPPPPSLPLGGSV 2856
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 3058 ALPDDIRREVLQNQLGIRPPTRTAPSTNS-SAPAVVGNPGVTEVSPEFLAALP-PAIQEEVLAQQRAEQQRRE---LAQN 3132
Cdd:PHA03247 2857 APGGDVRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFALPPDQPERPPqPQAPPPPQPQPQPPPPPQPqppPPPP 2936
|
330
....*....|....*..
gi 2462627860 3133 ASSDTPMDPVTFIQTLP 3149
Cdd:PHA03247 2937 PRPQPPLAPTTDPAGAG 2953
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| HECTc |
cd00078 |
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ... |
4102-4455 |
4.26e-161 |
|
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.
Pssm-ID: 238033 [Multi-domain] Cd Length: 352 Bit Score: 502.48 E-value: 4.26e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4102 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH 4181
Cdd:cd00078 3 ITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDSGLLYPNPSSF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4182 CNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEV 4261
Cdd:cd00078 83 ADEDHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGDEDDLELTFTIEL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4262 QE-FGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTI 4340
Cdd:cd00078 163 DSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICGSEDI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4341 DIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEgmngiQKFQIHRDDRSTDRLP 4419
Cdd:cd00078 243 DLEDLKKNTEYkGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLN-----PKFTIRRVGSPDDRLP 317
|
330 340 350
....*....|....*....|....*....|....*.
gi 2462627860 4420 SAHTCFNQLDLPAYESFEKLRHMLLLAIQECsEGFG 4455
Cdd:cd00078 318 TAHTCFNLLKLPPYSSKEILREKLLYAINEG-AGFG 352
|
|
| HECTc |
smart00119 |
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ... |
4126-4454 |
3.74e-159 |
|
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.
Pssm-ID: 214523 Cd Length: 328 Bit Score: 495.99 E-value: 3.74e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4126 KNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNR 4205
Cdd:smart00119 4 KRVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANEEHLSYFRFIGRVLGKALYDNR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4206 LLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYL-LENDVSTLgYDLTFSTEVQE-FGVCEVRDLKPNGANILVTE 4283
Cdd:smart00119 84 LLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEE-LDLTFSIVLTSeFGQVKVVELKPGGSNIPVTE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4284 ENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQ 4362
Cdd:smart00119 163 ENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYkGGYSANSQTIK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4363 WFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGmngiqKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHM 4442
Cdd:smart00119 243 WFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALSP-----KFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREK 317
|
330
....*....|..
gi 2462627860 4443 LLLAIQECsEGF 4454
Cdd:smart00119 318 LLLAINEG-KGF 328
|
|
| HUL4 |
COG5021 |
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]; |
4040-4457 |
7.06e-147 |
|
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227354 [Multi-domain] Cd Length: 872 Bit Score: 482.73 E-value: 7.06e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4040 RFAETHRTVLNQILRQSTTHL--ADGPFAVLVDYIRVLDFDVKRKYFRQeleRLDEGLRKEDMAVH--VRRDHVFEDSYR 4115
Cdd:COG5021 454 RLNNLYRFYFVEHRKKTLTKNdsRLGSFISLNKLDIRRIKEDKRRKLFY---SLKQKAKIFDPYLHikVRRDRVFEDSYR 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4116 ELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGR 4195
Cdd:COG5021 531 EIMDESGDDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFEYITEDLYTLPINPLSSINPEHLSYFKFLGR 610
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4196 IVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPN 4275
Cdd:COG5021 611 VIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLLNNDIDETILDLTFTVEDDSFGESRTVELIPN 690
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4276 GANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPT-IDIDDLKSNTEYHKY 4354
Cdd:COG5021 691 GRNISVTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGIPEdIDIDDWKSNTAYHGY 770
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4355 QSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYE 4434
Cdd:COG5021 771 TEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLQGSDGVRKFTIEKGGTDDDRLPSAHTCFNRLKLPEYS 850
|
410 420
....*....|....*....|...
gi 2462627860 4435 SFEKLRHMLLLAIQECSeGFGLA 4457
Cdd:COG5021 851 SKEKLRSKLLTAINEGA-GFGLL 872
|
|
| HECT |
pfam00632 |
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ... |
4151-4457 |
2.06e-120 |
|
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.
Pssm-ID: 459880 Cd Length: 304 Bit Score: 383.88 E-value: 2.06e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4151 IISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNH--LSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTD 4228
Cdd:pfam00632 2 LLSKELFDPNYGLFEYETEDDRTYWFNPSSSESPDLelLDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLED 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4229 MESEDYHFYQGLVYLLENDVSTLG-YDLTFSteVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLA 4307
Cdd:pfam00632 82 LESIDPELYKSLKSLLNMDNDDDEdLGLTFT--IPVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4308 AFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGT 4386
Cdd:pfam00632 160 AFRKGFYSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYdGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGS 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462627860 4387 SKVPLQGFAALegmngiQKFQIHR-DDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECsEGFGLA 4457
Cdd:pfam00632 240 SRLPVGGFKSL------PKFTIVRkGGDDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEG-EGFGLS 304
|
|
| DUF913 |
pfam06025 |
Domain of Unknown Function (DUF913); Members of this family are found in various ubiquitin ... |
431-897 |
1.16e-95 |
|
Domain of Unknown Function (DUF913); Members of this family are found in various ubiquitin protein ligases.
Pssm-ID: 461803 Cd Length: 369 Bit Score: 315.32 E-value: 1.16e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 431 RAVRVVD-LITNLD--MAAFQSHSGLSIFIYRLEHEVDLCRKECpfvikpkiqrpnttQEGEEMETDMdvadvamessPG 507
Cdd:pfam06025 1 RAVQFLDtLIYNFQdaFQAFRNAGGLDAIIDRIVHEVDSALELA--------------EAGKGTPSEY----------KS 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 508 SSISMEhrldvelrasgsssstnissgpspgpspgpgtgpgpgpgpgpgpgpgpgpgpgpgpgpgpgpgprpgvqcIP-Q 586
Cdd:pfam06025 57 SVVDYE----------------------------------------------------------------------IPyY 66
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 587 RAALLKSMLNFLKKAIQ--DPAFSDGIRHVMDGS-LPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNG 663
Cdd:pfam06025 67 RQQLLKWLLKFIHHMMQhsGGGTDRLLRNLIDSSqLLGSLRKIIENAKVFGSSVWSLAVNILSDFIHNEPTSFAVIQEAG 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 664 LTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRrrrssdPLGDTASNLG 743
Cdd:pfam06025 147 LSKAFLEAVLAKGILPSSEAINSIPNAFGAICLNNAGLELFKSSNALESFFEIFESPDHVKAME------TDGELASNLG 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 744 SAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDP--------KYICQKPSIQKADGTATAPPPRSNHAAEEASSEDEEE 815
Cdd:pfam06025 221 SSFDELVRHHPSLKPAIINAVIDMLARVVELGSTKaepdgwgaKLWVGCSSSSSFSPASSGSLPMETDGESGDESSSDED 300
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 816 EEVQAMQSFNSTQQNETEPNQQvvgteeripiPLMDYILNVMKFVESILSNNTtddHCQEFVNQKGLLPLVTILGLPNLP 895
Cdd:pfam06025 301 VEMEDAPDTDSTEETEPESHGN----------SLTDYIDNVARFLEAFFSNNS---HCSDFIEKGGIELLLDLATLPSLP 367
|
..
gi 2462627860 896 ID 897
Cdd:pfam06025 368 YD 369
|
|
| DUF908 |
pfam06012 |
Domain of Unknown Function (DUF908); |
92-367 |
7.75e-24 |
|
Domain of Unknown Function (DUF908);
Pssm-ID: 428721 Cd Length: 351 Bit Score: 106.26 E-value: 7.75e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 92 LLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKR-SNYITRLGSDKRTP-----------L 159
Cdd:pfam06012 5 LVEAILRFTRLLLENCGNRSIYNSSEHLNDLLNTTSLDVLLAALRLLLRLAQRySASNSRRGSAPRHIqqsllanhyniD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 160 LTRLQHLAESWG------------------GKENGFGLAECCRDLHmmKYPPS-ATTLHFEFYADPGAEVKIEK------ 214
Cdd:pfam06012 85 LDRLLKLAQPFPkppppdstdpapsttknsANEYANDLVSLAKEDS--KVLPSeWGSVKFTYYPSSSSDEAPTSskssts 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 215 -----------------------------------RTTSNTLHYIHIEQLDKISESPSEIMESLtkMYSIPKDKQMLLFT 259
Cdd:pfam06012 163 snsspstptplrrsstlgtspdspsspststpssaADSDEGLRTFEIPESKVASKSLEDILAKA--IEDLPKESRFELLH 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 260 HIRLAHGFSNHR--KRLQAVQARLHAISILVYSNALQESANSILY--NGLIEELVDVLQITDKQLMEIKAASLRTLTSIV 335
Cdd:pfam06012 241 RIRIAKALNSSSeeSRQQLLAIRLLAIANLAYIHPESTFQTKLFEydPDLVYQLAELIHPDTEVPLELQTAALYALEALA 320
|
330 340 350
....*....|....*....|....*....|..
gi 2462627860 336 HleRTPKLSSIIDCTGTASYHGFLPVLVRNCI 367
Cdd:pfam06012 321 R--HRAKLSDVLSALGANVNHGILLYVLRKAV 350
|
|
| UBA_HUWE1 |
cd14288 |
UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins; HUWE1, ... |
1400-1439 |
6.06e-15 |
|
UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins; HUWE1, also called ARF-binding protein 1 (ARF-BP1), HECT, UBA and WWE domain-containing protein 1, homologous to E6AP carboxyl terminus homologs protein 9 (HectH9), large structure of UREB1 (LASU1), Mcl-1 ubiquitin ligase E3 (Mule), upstream regulatory element-binding protein 1 (URE-B1), or URE-binding protein 1, may function as a ubiquitin-protein ligase that involves in the ubiquitination cascade that targets specific substrate proteins in proteolysis. It can ubiquitylate DNA polymerase beta (Pol beta), the major BER DNA polymerase and modulates base excision repair (BER). HUWE1 also acts as a critical mediator of both the p53-independent and p53-dependent tumor suppressor functions of ARF tumor suppressor in p53 regulation. Moreover, HUWE1 is both required and sufficient for the polyubiquitination of Mcl-1, an anti-apoptotic Bcl-2 family member involving in DNA damage-induced apoptosis. Furthermore, HUWE1 plays an important role in the regulation of Cdc6 stability after DNA damage. In addition, HUWE1 works as a partner of N-Myc oncoprotein in neural cells. It ubiquitinates N-Myc and primes it for proteasomal-mediated degradation. HUWE1 contains a ubiquitin-associated (UBA) domain, a WWE domain, and a Bcl-2 homology region 3 (BH3) domain at the N-terminus and a HECT domain at the C-terminus. WWE domain plays a role in the regulation of specific protein-protein interactions in a ubiquitin conjugation system. BH3 domain is responsible for the specific binding to Mcl-1. HECT domain involves in the inhibition of the transcriptional activity of p53 via a ubiquitin-dependent degradation pathway. It also controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
Pssm-ID: 270474 Cd Length: 40 Bit Score: 71.28 E-value: 6.06e-15
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2462627860 1400 VNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHP 1439
Cdd:cd14288 1 VNEAHLQQLMDMGFTREHALEALLHTSTLEQATEYLLTHP 40
|
|
| WWE |
pfam02825 |
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to ... |
1700-1761 |
4.54e-14 |
|
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems.
Pssm-ID: 460715 [Multi-domain] Cd Length: 66 Bit Score: 69.63 E-value: 4.54e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462627860 1700 WRWFDDRsGRWCSYSASNNSTIDSAWKSGETSV--RFTAGRRRYTVQFTTMVQVNEETGNRRPV 1761
Cdd:pfam02825 2 WEWEDDN-GGWHPYDPEVSSLIEEAYQKGKPSVdlSITTAGFPYTIDFKSMTQTNKDTGTTRPV 64
|
|
| WWE |
smart00678 |
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated ... |
1700-1761 |
9.64e-12 |
|
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis;
Pssm-ID: 128922 [Multi-domain] Cd Length: 73 Bit Score: 63.13 E-value: 9.64e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462627860 1700 WRW-FDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPV 1761
Cdd:smart00678 1 YVWeYEGRNGKWWPYDPRVSEDIEEAYAAGKKLCELSICGFPYTIDFNAMTQYNQATGTTRKV 63
|
|
| UBM |
pfam14377 |
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT ... |
3093-3126 |
1.08e-07 |
|
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and Arabidopsis UPL1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM).
Pssm-ID: 464159 [Multi-domain] Cd Length: 34 Bit Score: 50.58 E-value: 1.08e-07
10 20 30
....*....|....*....|....*....|....
gi 2462627860 3093 GNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQR 3126
Cdd:pfam14377 1 AAPPPEGIDPSFLAALPPDLRQEVLAQQDDERLR 34
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2818-3149 |
1.77e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.94 E-value: 1.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2818 SDGTPMPDSYPTTPSSTDAAtSESKETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGeggSSTQLLMPVEPEELGPTRP 2897
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDP-APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVG---SLTSLADPPPPPPTPEPAP 2712
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2898 SGEAETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASctleeavgdTSAAGSSEQPRAgsstPGDAP 2977
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT---------TAGPPAPAPPAA----PAAGP 2779
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2978 PAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSRGileEPLPSTSSEEEDPLAGISLPEGVDPSFLA 3057
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP---LPPPTSAQPTAPPPPPGPPPPSLPLGGSV 2856
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 3058 ALPDDIRREVLQNQLGIRPPTRTAPSTNS-SAPAVVGNPGVTEVSPEFLAALP-PAIQEEVLAQQRAEQQRRE---LAQN 3132
Cdd:PHA03247 2857 APGGDVRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFALPPDQPERPPqPQAPPPPQPQPQPPPPPQPqppPPPP 2936
|
330
....*....|....*..
gi 2462627860 3133 ASSDTPMDPVTFIQTLP 3149
Cdd:PHA03247 2937 PRPQPPLAPTTDPAGAG 2953
|
|
| UBM |
pfam14377 |
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT ... |
3048-3075 |
2.16e-06 |
|
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and Arabidopsis UPL1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM).
Pssm-ID: 464159 [Multi-domain] Cd Length: 34 Bit Score: 46.73 E-value: 2.16e-06
10 20
....*....|....*....|....*...
gi 2462627860 3048 PEGVDPSFLAALPDDIRREVLQNQLGIR 3075
Cdd:pfam14377 5 PEGIDPSFLAALPPDLRQEVLAQQDDER 32
|
|
| Rev1_UBM2 |
cd19318 |
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ... |
3051-3069 |
9.82e-03 |
|
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen.
Pssm-ID: 412037 Cd Length: 36 Bit Score: 36.43 E-value: 9.82e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| HECTc |
cd00078 |
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ... |
4102-4455 |
4.26e-161 |
|
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.
Pssm-ID: 238033 [Multi-domain] Cd Length: 352 Bit Score: 502.48 E-value: 4.26e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4102 VHVRRDHVFEDSYRELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSH 4181
Cdd:cd00078 3 ITVRRDRILEDALRQLSKVSSSDLKKVLEVEFVGEEGIDAGGVTREFFTLVSKELFNPSYGLFRYTPDDSGLLYPNPSSF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4182 CNPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEV 4261
Cdd:cd00078 83 ADEDHLKLFRFLGRLLGKALYEGRLLDLPFSRAFYKKLLGKPLSLEDLEELDPELYKSLKELLDNDGDEDDLELTFTIEL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4262 QE-FGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTI 4340
Cdd:cd00078 163 DSsFGGAVTVELKPGGRDIPVTNENKEEYVDLYVDYRLNKGIEEQVEAFRDGFSEVIPEELLSLFTPEELELLICGSEDI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4341 DIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEgmngiQKFQIHRDDRSTDRLP 4419
Cdd:cd00078 243 DLEDLKKNTEYkGGYSSDSPTIQWFWEVLESFTNEERKKFLQFVTGSSRLPVGGFADLN-----PKFTIRRVGSPDDRLP 317
|
330 340 350
....*....|....*....|....*....|....*.
gi 2462627860 4420 SAHTCFNQLDLPAYESFEKLRHMLLLAIQECsEGFG 4455
Cdd:cd00078 318 TAHTCFNLLKLPPYSSKEILREKLLYAINEG-AGFG 352
|
|
| HECTc |
smart00119 |
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ... |
4126-4454 |
3.74e-159 |
|
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.
Pssm-ID: 214523 Cd Length: 328 Bit Score: 495.99 E-value: 3.74e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4126 KNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNR 4205
Cdd:smart00119 4 KRVLEIEFEGEEGLDGGGVTREFFFLLSKELFNPDYGLFRYSPNDYLLYPNPRSGFANEEHLSYFRFIGRVLGKALYDNR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4206 LLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYL-LENDVSTLgYDLTFSTEVQE-FGVCEVRDLKPNGANILVTE 4283
Cdd:smart00119 84 LLDLFFARPFYKKLLGKPVTLHDLESLDPELYKSLKWLlLNNDTSEE-LDLTFSIVLTSeFGQVKVVELKPGGSNIPVTE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4284 ENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQ 4362
Cdd:smart00119 163 ENKKEYVHLVIEYRLNKGIEKQLEAFREGFSEVIPENLLKLFDPEELELLICGSPEIDVDDLKSNTEYkGGYSANSQTIK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4363 WFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGmngiqKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHM 4442
Cdd:smart00119 243 WFWEVVESFTNEERRKLLQFVTGSSRLPVGGFAALSP-----KFTIRKAGSDDERLPTAHTCFNRLKLPPYSSKEILREK 317
|
330
....*....|..
gi 2462627860 4443 LLLAIQECsEGF 4454
Cdd:smart00119 318 LLLAINEG-KGF 328
|
|
| HUL4 |
COG5021 |
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]; |
4040-4457 |
7.06e-147 |
|
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227354 [Multi-domain] Cd Length: 872 Bit Score: 482.73 E-value: 7.06e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4040 RFAETHRTVLNQILRQSTTHL--ADGPFAVLVDYIRVLDFDVKRKYFRQeleRLDEGLRKEDMAVH--VRRDHVFEDSYR 4115
Cdd:COG5021 454 RLNNLYRFYFVEHRKKTLTKNdsRLGSFISLNKLDIRRIKEDKRRKLFY---SLKQKAKIFDPYLHikVRRDRVFEDSYR 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4116 ELHRKSPEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNHLSYFKFVGR 4195
Cdd:COG5021 531 EIMDESGDDLKKTLEIEFVGEEGIDAGGLTREWLFLLSKEMFNPDYGLFEYITEDLYTLPINPLSSINPEHLSYFKFLGR 610
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4196 IVAKAVYDNRLLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLENDVSTLGYDLTFSTEVQEFGVCEVRDLKPN 4275
Cdd:COG5021 611 VIGKAIYDSRILDVQFSKAFYKKLLGKPVSLVDLESLDPELYRSLVWLLNNDIDETILDLTFTVEDDSFGESRTVELIPN 690
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4276 GANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPT-IDIDDLKSNTEYHKY 4354
Cdd:COG5021 691 GRNISVTNENKKEYVKKVVDYKLNKRVEKQFSAFKSGFSEIIPPDLLQIFDESELELLIGGIPEdIDIDDWKSNTAYHGY 770
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4355 QSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYE 4434
Cdd:COG5021 771 TEDSPIIVWFWEIISEFDFEERAKLLQFVTGTSRIPINGFKDLQGSDGVRKFTIEKGGTDDDRLPSAHTCFNRLKLPEYS 850
|
410 420
....*....|....*....|...
gi 2462627860 4435 SFEKLRHMLLLAIQECSeGFGLA 4457
Cdd:COG5021 851 SKEKLRSKLLTAINEGA-GFGLL 872
|
|
| HECT |
pfam00632 |
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ... |
4151-4457 |
2.06e-120 |
|
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.
Pssm-ID: 459880 Cd Length: 304 Bit Score: 383.88 E-value: 2.06e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4151 IISREMFNPMYALFRTSPGDRVTYTINPSSHCNPNH--LSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKSVRYTD 4228
Cdd:pfam00632 2 LLSKELFDPNYGLFEYETEDDRTYWFNPSSSESPDLelLDYFKFLGKLLGKAIYNGILLDLPFPPFFYKKLLGEPLTLED 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4229 MESEDYHFYQGLVYLLENDVSTLG-YDLTFSteVQEFGVCEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLA 4307
Cdd:pfam00632 82 LESIDPELYKSLKSLLNMDNDDDEdLGLTFT--IPVFGESKTIELIPNGRNIPVTNENKEEYIRLYVDYRLNKSIEPQLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 4308 AFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEY-HKYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGT 4386
Cdd:pfam00632 160 AFRKGFYSVIPKEALSLFTPEELELLICGSPEIDVEDLKKNTEYdGGYTKNSPTIQWFWEILEEFSPEQRRLFLKFVTGS 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462627860 4387 SKVPLQGFAALegmngiQKFQIHR-DDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECsEGFGLA 4457
Cdd:pfam00632 240 SRLPVGGFKSL------PKFTIVRkGGDDDDRLPTAHTCFNRLKLPDYSSKEILKEKLLIAIEEG-EGFGLS 304
|
|
| DUF913 |
pfam06025 |
Domain of Unknown Function (DUF913); Members of this family are found in various ubiquitin ... |
431-897 |
1.16e-95 |
|
Domain of Unknown Function (DUF913); Members of this family are found in various ubiquitin protein ligases.
Pssm-ID: 461803 Cd Length: 369 Bit Score: 315.32 E-value: 1.16e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 431 RAVRVVD-LITNLD--MAAFQSHSGLSIFIYRLEHEVDLCRKECpfvikpkiqrpnttQEGEEMETDMdvadvamessPG 507
Cdd:pfam06025 1 RAVQFLDtLIYNFQdaFQAFRNAGGLDAIIDRIVHEVDSALELA--------------EAGKGTPSEY----------KS 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 508 SSISMEhrldvelrasgsssstnissgpspgpspgpgtgpgpgpgpgpgpgpgpgpgpgpgpgpgpgpgprpgvqcIP-Q 586
Cdd:pfam06025 57 SVVDYE----------------------------------------------------------------------IPyY 66
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 587 RAALLKSMLNFLKKAIQ--DPAFSDGIRHVMDGS-LPTSLKHIISNAEYYGPSLFLLATEVVTVFVFQEPSLLSSLQDNG 663
Cdd:pfam06025 67 RQQLLKWLLKFIHHMMQhsGGGTDRLLRNLIDSSqLLGSLRKIIENAKVFGSSVWSLAVNILSDFIHNEPTSFAVIQEAG 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 664 LTDVMLHALLIKDVPATREVLGSLPNVFSALCLNARGLQSFVQCQPFERLFKVLLSPDYLPAMRrrrssdPLGDTASNLG 743
Cdd:pfam06025 147 LSKAFLEAVLAKGILPSSEAINSIPNAFGAICLNNAGLELFKSSNALESFFEIFESPDHVKAME------TDGELASNLG 220
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 744 SAVDELMRHQPTLKTDATTAIIKLLEEICNLGRDP--------KYICQKPSIQKADGTATAPPPRSNHAAEEASSEDEEE 815
Cdd:pfam06025 221 SSFDELVRHHPSLKPAIINAVIDMLARVVELGSTKaepdgwgaKLWVGCSSSSSFSPASSGSLPMETDGESGDESSSDED 300
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 816 EEVQAMQSFNSTQQNETEPNQQvvgteeripiPLMDYILNVMKFVESILSNNTtddHCQEFVNQKGLLPLVTILGLPNLP 895
Cdd:pfam06025 301 VEMEDAPDTDSTEETEPESHGN----------SLTDYIDNVARFLEAFFSNNS---HCSDFIEKGGIELLLDLATLPSLP 367
|
..
gi 2462627860 896 ID 897
Cdd:pfam06025 368 YD 369
|
|
| DUF908 |
pfam06012 |
Domain of Unknown Function (DUF908); |
92-367 |
7.75e-24 |
|
Domain of Unknown Function (DUF908);
Pssm-ID: 428721 Cd Length: 351 Bit Score: 106.26 E-value: 7.75e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 92 LLLAVLNFTALLIEYSFSRHLYSSIEHLTTLLASSDMQVVLAVLNLLYVFSKR-SNYITRLGSDKRTP-----------L 159
Cdd:pfam06012 5 LVEAILRFTRLLLENCGNRSIYNSSEHLNDLLNTTSLDVLLAALRLLLRLAQRySASNSRRGSAPRHIqqsllanhyniD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 160 LTRLQHLAESWG------------------GKENGFGLAECCRDLHmmKYPPS-ATTLHFEFYADPGAEVKIEK------ 214
Cdd:pfam06012 85 LDRLLKLAQPFPkppppdstdpapsttknsANEYANDLVSLAKEDS--KVLPSeWGSVKFTYYPSSSSDEAPTSskssts 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 215 -----------------------------------RTTSNTLHYIHIEQLDKISESPSEIMESLtkMYSIPKDKQMLLFT 259
Cdd:pfam06012 163 snsspstptplrrsstlgtspdspsspststpssaADSDEGLRTFEIPESKVASKSLEDILAKA--IEDLPKESRFELLH 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 260 HIRLAHGFSNHR--KRLQAVQARLHAISILVYSNALQESANSILY--NGLIEELVDVLQITDKQLMEIKAASLRTLTSIV 335
Cdd:pfam06012 241 RIRIAKALNSSSeeSRQQLLAIRLLAIANLAYIHPESTFQTKLFEydPDLVYQLAELIHPDTEVPLELQTAALYALEALA 320
|
330 340 350
....*....|....*....|....*....|..
gi 2462627860 336 HleRTPKLSSIIDCTGTASYHGFLPVLVRNCI 367
Cdd:pfam06012 321 R--HRAKLSDVLSALGANVNHGILLYVLRKAV 350
|
|
| UBA_HUWE1 |
cd14288 |
UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins; HUWE1, ... |
1400-1439 |
6.06e-15 |
|
UBA domain found in eukaryotic E3 ubiquitin-protein ligase HUWE1 and similar proteins; HUWE1, also called ARF-binding protein 1 (ARF-BP1), HECT, UBA and WWE domain-containing protein 1, homologous to E6AP carboxyl terminus homologs protein 9 (HectH9), large structure of UREB1 (LASU1), Mcl-1 ubiquitin ligase E3 (Mule), upstream regulatory element-binding protein 1 (URE-B1), or URE-binding protein 1, may function as a ubiquitin-protein ligase that involves in the ubiquitination cascade that targets specific substrate proteins in proteolysis. It can ubiquitylate DNA polymerase beta (Pol beta), the major BER DNA polymerase and modulates base excision repair (BER). HUWE1 also acts as a critical mediator of both the p53-independent and p53-dependent tumor suppressor functions of ARF tumor suppressor in p53 regulation. Moreover, HUWE1 is both required and sufficient for the polyubiquitination of Mcl-1, an anti-apoptotic Bcl-2 family member involving in DNA damage-induced apoptosis. Furthermore, HUWE1 plays an important role in the regulation of Cdc6 stability after DNA damage. In addition, HUWE1 works as a partner of N-Myc oncoprotein in neural cells. It ubiquitinates N-Myc and primes it for proteasomal-mediated degradation. HUWE1 contains a ubiquitin-associated (UBA) domain, a WWE domain, and a Bcl-2 homology region 3 (BH3) domain at the N-terminus and a HECT domain at the C-terminus. WWE domain plays a role in the regulation of specific protein-protein interactions in a ubiquitin conjugation system. BH3 domain is responsible for the specific binding to Mcl-1. HECT domain involves in the inhibition of the transcriptional activity of p53 via a ubiquitin-dependent degradation pathway. It also controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein.
Pssm-ID: 270474 Cd Length: 40 Bit Score: 71.28 E-value: 6.06e-15
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2462627860 1400 VNQQQLQQLMDMGFTREHAMEALLNTSTMEQATEYLLTHP 1439
Cdd:cd14288 1 VNEAHLQQLMDMGFTREHALEALLHTSTLEQATEYLLTHP 40
|
|
| WWE |
pfam02825 |
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to ... |
1700-1761 |
4.54e-14 |
|
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems.
Pssm-ID: 460715 [Multi-domain] Cd Length: 66 Bit Score: 69.63 E-value: 4.54e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462627860 1700 WRWFDDRsGRWCSYSASNNSTIDSAWKSGETSV--RFTAGRRRYTVQFTTMVQVNEETGNRRPV 1761
Cdd:pfam02825 2 WEWEDDN-GGWHPYDPEVSSLIEEAYQKGKPSVdlSITTAGFPYTIDFKSMTQTNKDTGTTRPV 64
|
|
| WWE |
smart00678 |
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated ... |
1700-1761 |
9.64e-12 |
|
Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis;
Pssm-ID: 128922 [Multi-domain] Cd Length: 73 Bit Score: 63.13 E-value: 9.64e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462627860 1700 WRW-FDDRSGRWCSYSASNNSTIDSAWKSGETSVRFTAGRRRYTVQFTTMVQVNEETGNRRPV 1761
Cdd:smart00678 1 YVWeYEGRNGKWWPYDPRVSEDIEEAYAAGKKLCELSICGFPYTIDFNAMTQYNQATGTTRKV 63
|
|
| UBM |
pfam14377 |
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT ... |
3093-3126 |
1.08e-07 |
|
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and Arabidopsis UPL1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM).
Pssm-ID: 464159 [Multi-domain] Cd Length: 34 Bit Score: 50.58 E-value: 1.08e-07
10 20 30
....*....|....*....|....*....|....
gi 2462627860 3093 GNPGVTEVSPEFLAALPPAIQEEVLAQQRAEQQR 3126
Cdd:pfam14377 1 AAPPPEGIDPSFLAALPPDLRQEVLAQQDDERLR 34
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2818-3149 |
1.77e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.94 E-value: 1.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2818 SDGTPMPDSYPTTPSSTDAAtSESKETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGeggSSTQLLMPVEPEELGPTRP 2897
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDP-APGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVG---SLTSLADPPPPPPTPEPAP 2712
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2898 SGEAETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSPMDTSSLASctleeavgdTSAAGSSEQPRAgsstPGDAP 2977
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT---------TAGPPAPAPPAA----PAAGP 2779
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2978 PAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSRGileEPLPSTSSEEEDPLAGISLPEGVDPSFLA 3057
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP---LPPPTSAQPTAPPPPPGPPPPSLPLGGSV 2856
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 3058 ALPDDIRREVLQNQLGIRPPTRTAPSTNS-SAPAVVGNPGVTEVSPEFLAALP-PAIQEEVLAQQRAEQQRRE---LAQN 3132
Cdd:PHA03247 2857 APGGDVRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFALPPDQPERPPqPQAPPPPQPQPQPPPPPQPqppPPPP 2936
|
330
....*....|....*..
gi 2462627860 3133 ASSDTPMDPVTFIQTLP 3149
Cdd:PHA03247 2937 PRPQPPLAPTTDPAGAG 2953
|
|
| UBM |
pfam14377 |
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT ... |
3048-3075 |
2.16e-06 |
|
Ubiquitin binding region; This family contains repetitive element (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and Arabidopsis UPL1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM).
Pssm-ID: 464159 [Multi-domain] Cd Length: 34 Bit Score: 46.73 E-value: 2.16e-06
10 20
....*....|....*....|....*...
gi 2462627860 3048 PEGVDPSFLAALPDDIRREVLQNQLGIR 3075
Cdd:pfam14377 5 PEGIDPSFLAALPPDLRQEVLAQQDDER 32
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
2805-3041 |
8.93e-06 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 52.23 E-value: 8.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2805 TASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKETLGTlQSSQQQPTLPTPPALGEVPQeLQSPAGEGGSSTqll 2884
Cdd:pfam05109 499 TESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGK-TSPTSAVTTPTPNATSPTPA-VTTPTPNATIPT--- 573
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2885 mpvepeeLGPTRPSgEAETTQMELSPAPTITSLSPERAEDSDALTAVSSqlegSPMDTSSLASCTLEEAVGDTSAAGSSe 2964
Cdd:pfam05109 574 -------LGKTSPT-SAVTTPTPNATSPTVGETSPQANTTNHTLGGTSS----TPVVTSPPKNATSAVTTGQHNITSSS- 640
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462627860 2965 qpragSSTPGDAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSRGILEEPLPSTSSEEEDP 3041
Cdd:pfam05109 641 -----TSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASGP 712
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
2805-3111 |
1.56e-05 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 51.46 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2805 TASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKETLGtLQSSQQQPT-LPTPPALGEV--PQELQSPAGEGGSST 2881
Cdd:pfam05109 406 TRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAAPNTTTG-LPSSTHVPTnLTAPASTGPTvsTADVTSPTPAGTTSG 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2882 QllMPVEP---------EELGP--TRPSGEAET-TQMELSPAPTITSLSPERAEDSDALTAVSSQLEG-SPMDTSSLASC 2948
Cdd:pfam05109 485 A--SPVTPspsprdngtESKAPdmTSPTSAVTTpTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTpTPNATSPTPAV 562
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2949 TLEE------AVGDTS--AAGSSEQPRAGSSTPGDAPPAVAEVQGRSDGSGES---AQPPEDSSPPASSESSSTRDSAVA 3017
Cdd:pfam05109 563 TTPTpnatipTLGKTSptSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTpvvTSPPKNATSAVTTGQHNITSSSTS 642
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 3018 ISGADSRGILEEPLPSTS--SEEEDPLAGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPS--TNSSAPAVVG 3093
Cdd:pfam05109 643 SMSLRPSSISETLSPSTSdnSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASgpGNSSTSTKPG 722
|
330
....*....|....*...
gi 2462627860 3094 NPGVTEVSPEFLAALPPA 3111
Cdd:pfam05109 723 EVNVTKGTPPKNATSPQA 740
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
2787-3122 |
3.00e-05 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 49.96 E-value: 3.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2787 ITDKGKEDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSESKETlgTLQSSQQQPTLPTP-----P 2861
Cdd:pfam17823 29 VLNKMWNGAGKQNASGDAVPRADNKSSEQ*NFCAATAAPAPVTLTKGTSAAHLNSTEV--TAEHTPHGTDLSEPatregA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2862 ALGEVPQELQSPAGEGGSSTQLLMPVE---PEELGPTRPSGEAETTQMELSP--------APTITSLSPERAEDSDALTA 2930
Cdd:pfam17823 107 ADGAASRALAAAASSSPSSAAQSLPAAiaaLPSEAFSAPRAAACRANASAAPraaiaaasAPHAASPAPRTAASSTTAAS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2931 VSSQLEGSPMDTSSLASCTLEEAVGDTSAAGSSEQPRAGSSTPgdAPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSS 3010
Cdd:pfam17823 187 STTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALA--AVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 3011 TRDSAVAISGADSR-----------GILEEPLPSTSSEEEDPLAGISL--------PEGVDPSFLAALPDDIRREVLQNQ 3071
Cdd:pfam17823 265 SAAGTINMGDPHARrlspakhmpsdTMARNPAAPMGAQAQGPIIQVSTdqpvhntaGEPTPSPSNTTLEPNTPKSVASTN 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 2462627860 3072 LGIRPPTRTAPSTNSSAPAVVGNpgvTEVSPEFLAALPPAIQEEVLAQQRA 3122
Cdd:pfam17823 345 LAVVTTTKAQAKEPSASPVPVLH---TSMIPEVEATSPTTQPSPLLPTQGA 392
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
2854-3076 |
4.44e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 49.98 E-value: 4.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2854 QPTLPTPPALGEVPQELQSPAGeggsstqllmPVEPEELGPTRPSGEAeTTQMELSPAPTITSLSPERAEDSDALTAVSS 2933
Cdd:PRK07764 596 GGEGPPAPASSGPPEEAARPAA----------PAAPAAPAAPAPAGAA-AAPAEASAAPAPGVAAPEHHPKHVAVPDASD 664
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2934 QLEGSPMDTSSLASCTLEEA------VGDTSAAGSSEQPR-------AGSSTPGDAPPAVAEVQGRSDGSGESAQPPEDS 3000
Cdd:PRK07764 665 GGDGWPAKAGGAAPAAPPPApapaapAAPAGAAPAQPAPApaatppaGQADDPAAQPPQAAQGASAPSPAADDPVPLPPE 744
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462627860 3001 SPPASSESSSTRDSAVAISGADSRGILEEPLPSTSSEEEDPLAgiSLPEGVDPSFLAAlPDDIRREVLQNQLGIRP 3076
Cdd:PRK07764 745 PDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAE--DDAPSMDDEDRRD-AEEVAMELLEEELGAKK 817
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2824-3209 |
5.68e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.94 E-value: 5.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2824 PDSYPTTPSSTDAATSESKETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEG-----------GSSTQLLMPVEPEEL 2892
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPArparppttagpPAPAPPAAPAAGPPR 2781
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2893 GPTRPSGEAETTQMELSPAPTITSLSPERAED-SDALTAVSSQLEGSPMDTSSL------------ASCTLEEAV---GD 2956
Cdd:PHA03247 2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLApAAALPPAASPAGPLPPPTSAQptapppppgpppPSLPLGGSVapgGD 2861
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2957 TSAAGSSEQPRAGSSTPGDaPPAVAEVQGRSDGSGESAQPPEDSSPPASSESSSTRDSAVAISGADSRgilEEPLPSTSS 3036
Cdd:PHA03247 2862 VRRRPPSRSPAAKPAAPAR-PPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ---PQPPPPPPP 2937
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 3037 EEEDPL------AGISLPEGVDPSFLAALPDDIRREVLQNQLGIRPPTRTAPSTNSSAPAVVGNPGVTEVSpeflaalpp 3110
Cdd:PHA03247 2938 RPQPPLapttdpAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWA--------- 3008
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 3111 aiqeevlaqqraeqqrRELAQNASSDTPmdPVTFIQTL-PSD---------LRRSVLEDMEDSVLAVMPPD----IAAEA 3176
Cdd:PHA03247 3009 ----------------SSLALHEETDPP--PVSLKQTLwPPDdtedsdadsLFDSDSERSDLEALDPLPPEphdpFAHEP 3070
|
410 420 430
....*....|....*....|....*....|...
gi 2462627860 3177 QALRREQEARQRQLMHerlFGHSSTSALSAILR 3209
Cdd:PHA03247 3071 DPATPEAGARESPSSQ---FGPPPLSANAALSR 3100
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
2793-2996 |
1.66e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 47.66 E-value: 1.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2793 EDKENRDQSAQCTASKSNDSTEQNLSDGTPMPDSYPTTpSSTDAATSESKETLGtlQSSQQQPTLPTPPALGEVPQELQS 2872
Cdd:PHA03169 63 EQGHRQTESDTETAEESRHGEKEERGQGGPSGSGSESV-GSPTPSPSGSAEELA--SGLSPENTSGSSPESPASHSPPPS 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2873 PAGEGGSSTqllmPVEPEELGPT---RPSGEAE-TTQMELSPAPTITSLSPERAEDS-DALTAVSSQLEGSPMDTSSL-A 2946
Cdd:PHA03169 140 PPSHPGPHE----PAPPESHNPSpnqQPSSFLQpSHEDSPEEPEPPTSEPEPDSPGPpQSETPTSSPPPQSPPDEPGEpQ 215
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 2462627860 2947 SCTLEEA-VGDTSAAGSSEQPRAGSSTPGDAPPAVAEVQGRSDGSGESAQP 2996
Cdd:PHA03169 216 SPTPQQApSPNTQQAVEHEDEPTEPEREGPPFPGHRSHSYTVVGWKPSTRP 266
|
|
| UBA_atUPL1_2_like |
cd14327 |
UBA domain found in Arabidopsis thaliana E3 ubiquitin-protein ligase UPL1 (atUPL1), UPL2 ... |
1409-1438 |
2.61e-04 |
|
UBA domain found in Arabidopsis thaliana E3 ubiquitin-protein ligase UPL1 (atUPL1), UPL2 (atUPL2) and similar proteins; The family includes two highly similar 405-kDa HECT E3 ubiquitin-protein ligases (UPLs), UPL1 and UPL2, from Arabidopsis thaliana. The HECT E3 UPL family plays a prominent role in the ubiquitination of plant proteins. The biological functions of UPL1 and UPL2 remain unclear. Both of them contain a ubiquitin-associated (UBA) domain and a C-terminal HECT domain. UBA domain may be involved in ubiquitin metabolism. HECT domain is necessary and sufficient for their E3 catalytic activity, but requires ATP, E1 and an E2 of the Arabidopsis UBC8 family to ubiquitinate proteins.
Pssm-ID: 270512 [Multi-domain] Cd Length: 38 Bit Score: 41.13 E-value: 2.61e-04
10 20 30
....*....|....*....|....*....|..
gi 2462627860 1409 MDMGFTREHAMEAL--LNTSTMEQATEYLLTH 1438
Cdd:cd14327 7 VEMGFSRERAEEALraVGTNSVELAMEWLFTN 38
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
2860-3133 |
2.11e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 44.46 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2860 PPALGEVPQELQSPAGEGGSSTQLLMPVEPEELGPTRPSGEAETTQMELSPAPTITSLSPERAEDSDALTAVSSQLEGSP 2939
Cdd:PRK07003 368 PGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDA 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2940 MDTSSLASCTLEEAVGDTSAAGSSEQPRAGSSTPGDAPPAVA-EVQGRSDGSGESAQPPEDSSPPASsessstrdsavAI 3018
Cdd:PRK07003 448 PVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAfEPAPRAAAPSAATPAAVPDARAPA-----------AA 516
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 3019 SGADSRGILEEPLPSTSSEEedPLAGISLPEGVDPSflAALpddirrEVLQNQlGIRpptrtAPSTNSSAPAVVGNPGVT 3098
Cdd:PRK07003 517 SREDAPAAAAPPAPEARPPT--PAAAAPAARAGGAA--AAL------DVLRNA-GMR-----VSSDRGARAAAAAKPAAA 580
|
250 260 270
....*....|....*....|....*....|....*.
gi 2462627860 3099 EVSPEFLAALPPAIQEEVL-AQQRAEQQRRELAQNA 3133
Cdd:PRK07003 581 PAAAPKPAAPRVAVQVPTPrARAATGDAPPNGAARA 616
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
2825-3102 |
6.21e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 42.85 E-value: 6.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2825 DSYPTTPSSTDAATSESKETLGTLQSSQQQPTLPTPPALGEVPQELQSPAGEGGSSTQLlMPVEPEELGPTRPSGEAETT 2904
Cdd:PHA03307 60 AACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPP-PTPPPASPPPSPAPDLSEML 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2905 QMELSPAPtitslspeRAEDSDALTAVSSQLEGSPMDTSSLASCTLEeAVGDTSAAGSSEQPRAGSSTPGDAPPAVAEVQ 2984
Cdd:PHA03307 139 RPVGSPGP--------PPAASPPAAGASPAAVASDAASSRQAALPLS-SPEETARAPSSPPAEPPPSTPPAAASPRPPRR 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2985 GRSDGSGesaqppedssppassesssTRDSAVAISGADSRGILEEPLPSTSSEEEDPLAGISLPEGVDPSFLAALPDDIR 3064
Cdd:PHA03307 210 SSPISAS-------------------ASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIW 270
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 2462627860 3065 REVLQNQLGIRP-PTRTAPSTNSSAPAVV-GNPGVTEVSP 3102
Cdd:PHA03307 271 EASGWNGPSSRPgPASSSSSPRERSPSPSpSSPGSGPAPS 310
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
2786-3048 |
8.98e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 41.88 E-value: 8.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2786 KITDKGKEDKENRDQSAQCTAS-KSNDSTEQNLSDGTPMPDSYPTTPSSTDAATSE---SKETLGtlQSSQQqptlptpp 2861
Cdd:PHA03169 24 KRHGGTREQAGRRRGTAARAAKpAPPAPTTSGPQVRAVAEQGHRQTESDTETAEESrhgEKEERG--QGGPS-------- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2862 alGEVPQELQSP-AGEGGSStqllmPVEPEELGPTRPSGEAETTQMELSPAPTitslspERAEDSDALTAVSSQLEGSPM 2940
Cdd:PHA03169 94 --GSGSESVGSPtPSPSGSA-----EELASGLSPENTSGSSPESPASHSPPPS------PPSHPGPHEPAPPESHNPSPN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462627860 2941 DT-SSLASCTLEEavGDTSAAGSSEQPRAGSSTPGDAPpavaevqgrsdgSGESAQPPEDSSPPASSESSSTRDSAVAIS 3019
Cdd:PHA03169 161 QQpSSFLQPSHED--SPEEPEPPTSEPEPDSPGPPQSE------------TPTSSPPPQSPPDEPGEPQSPTPQQAPSPN 226
|
250 260
....*....|....*....|....*....
gi 2462627860 3020 GADsrGILEEPLPSTSSEEEDPLAGISLP 3048
Cdd:PHA03169 227 TQQ--AVEHEDEPTEPEREGPPFPGHRSH 253
|
|
| Rev1_UBM2 |
cd19318 |
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ... |
3051-3069 |
9.82e-03 |
|
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen.
Pssm-ID: 412037 Cd Length: 36 Bit Score: 36.43 E-value: 9.82e-03
|
| |
