NCBI Conserved Domain Search

Conserved domains on [gi|2462628021|ref|XP_054182341|]

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sex comb on midleg-like protein 2 isoform X1 [Homo sapiens]

Protein Classification

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List of domain hits

Name

Accession

Description

Interval

E-value

MBT super family

cl45897

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...

33-162

3.26e-77

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes methylated lysine residues on histones and are thought to affect a variety of chromatin processes, including transcription. It exists as tandem repeats and is found in a number of nuclear proteins such as Drosophila sex comb on midleg protein. In the human genome, there are at least 9 MBT repeat proteins, each containing two, three or four MBT repeats. MBT repeat proteins use a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine (monomethyllysine and/or dimethyllysine).

The actual alignment was detected with superfamily member cd20105:

Pssm-ID: 459242 Cd Length: 131 Bit Score: 243.36 E-value: 3.26e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  33 FHWEEYLKETGSISAPSECFRQSQIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDS 112
Cdd:cd20105     2 FSWDKYLKETGAVPAPVHCFKQSYTPPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462628021 113 PDIQPVGTCEKEGDLLQPPLGYQMNTSSWPMFLLKTLNGSEMASATLFKK 162
Cdd:cd20105    82 SEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPVRIFHK 131

MBT_SCML2_rpt2

cd20109

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) ...

167-243

1.35e-53

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) and similar proteins; SCML2 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439099 Cd Length: 77 Bit Score: 178.54 E-value: 1.35e-53

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462628021 167 PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTS 243
Cdd:cd20109     1 PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVFITFDGWRGAFDYWCKYDSRDIFPVGWCRLTGDVLQPPGNS 77

SLED

pfam12140

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding ...

356-465

2.83e-51

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding domain found in Scml2 which is a member of the Polycomb group of proteins involved in epigenetic gene silencing.

Pssm-ID: 463469 Cd Length: 112 Bit Score: 173.54 E-value: 2.83e-51

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021 356 TVCVYVNKHGNFGPHLDPKRIQQLPDHFGPGPVNVVLRRIVQACVDCALETKTVFGYLKPDNRG-GEVITASFDGETHSI 434
Cdd:pfam12140   1 TVCIYVNKNCFCGPHLDKKKIAELPDQFGPGPVSLVLKEVLQALIDCAYDPKQVLKLLKSGNGGrEEIITAKYEGKTHTV 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462628021 435 QLPPVNSASFALRFLENFCHSLQ-CDNLLSSQ 465
Cdd:pfam12140  81 KLPIVNSASDVWRFLEKLCEKLGcCENLFSPQ 112

SAM_Scm

cd09578

SAM domain of Scm proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm (Sex ...

625-696

2.81e-44

SAM domain of Scm proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm (Sex comb on midleg) subfamily of Polycomb group is a protein-protein interaction domain. Proteins of this subfamily are transcriptional repressors associated with PRC1 complex. This group includes invertebrate Scm protein and chordate Scm homolog 1 and Scm-like 1, 2, 3 proteins. Most have a SAM domain, two MBT repeats, and a DUF3588 domain, except Scm-like 4 proteins which do not have MBT repeats. Originally the Scm protein was described in Drosophila as a regulator required for proper spatial expression of homeotic genes. It plays a major role during early embryogenesis. SAM domains of Scm proteins can interact with each other, forming homooligomers, as well as with SAM domains of other proteins, in particular with SAM domains of Ph (polyhomeotic) proteins, forming heterooligomers. Homooligomers are similar to the ones formed by SAM Pointed domains of the TEL proteins. Such SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome. Mammalian Scmh1 protein is known be indispensible member of PRC1 complex; it plays a regulatory role for the complex during meiotic prophase of male sperm cells, and is particularly involved in regulation of chromatin modification at the XY chromatin domain of the pachytene spermatocytes.

Pssm-ID: 188977 Cd Length: 72 Bit Score: 152.96 E-value: 2.81e-44

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462628021 625 SKDPSTWSVDEVIQFMKHTDPQISGPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLKE 696
Cdd:cd09578     1 SKDPSTWSVEDVVQFIKEADPQALAPHVDLFRKHEIDGKALLLLNSDMMMKYMGLKLGPALKLCYHIDKLKQ 72

RBR

pfam17208

RNA binding Region;

277-324

1.38e-13

RNA binding Region;

Pssm-ID: 465382 [Multi-domain] Cd Length: 56 Bit Score: 65.47 E-value: 1.38e-13

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462628021 277 TQQVRRSSRIKPPGPTAVPKRSSSVKNI--------TPRKKGPNSGKKEKPLPVIC 324
Cdd:pfam17208   1 GQRGRKPGRGKPPGSTSAPKKGSSPKNApakkepikIPKKRGPKPGSKRKPRPVLS 56

Name

Accession

Description

Interval

E-value

MBT_SCMH1_rpt1

cd20105

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...

33-162

3.26e-77

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1; Sex comb on midleg homolog 1 (SCMH1) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439095 Cd Length: 131 Bit Score: 243.36 E-value: 3.26e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  33 FHWEEYLKETGSISAPSECFRQSQIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDS 112
Cdd:cd20105     2 FSWDKYLKETGAVPAPVHCFKQSYTPPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462628021 113 PDIQPVGTCEKEGDLLQPPLGYQMNTSSWPMFLLKTLNGSEMASATLFKK 162
Cdd:cd20105    82 SEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPVRIFHK 131

MBT_SCML2_rpt2

cd20109

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) ...

167-243

1.35e-53

Pssm-ID: 439099 Cd Length: 77 Bit Score: 178.54 E-value: 1.35e-53

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462628021 167 PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTS 243
Cdd:cd20109     1 PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVFITFDGWRGAFDYWCKYDSRDIFPVGWCRLTGDVLQPPGNS 77

SLED

pfam12140

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding ...

356-465

2.83e-51

Pssm-ID: 463469 Cd Length: 112 Bit Score: 173.54 E-value: 2.83e-51

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021 356 TVCVYVNKHGNFGPHLDPKRIQQLPDHFGPGPVNVVLRRIVQACVDCALETKTVFGYLKPDNRG-GEVITASFDGETHSI 434
Cdd:pfam12140   1 TVCIYVNKNCFCGPHLDKKKIAELPDQFGPGPVSLVLKEVLQALIDCAYDPKQVLKLLKSGNGGrEEIITAKYEGKTHTV 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462628021 435 QLPPVNSASFALRFLENFCHSLQ-CDNLLSSQ 465
Cdd:pfam12140  81 KLPIVNSASDVWRFLEKLCEKLGcCENLFSPQ 112

SAM_Scm

cd09578

SAM domain of Scm proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm (Sex ...

625-696

2.81e-44

Pssm-ID: 188977 Cd Length: 72 Bit Score: 152.96 E-value: 2.81e-44

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462628021 625 SKDPSTWSVDEVIQFMKHTDPQISGPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLKE 696
Cdd:cd09578     1 SKDPSTWSVEDVVQFIKEADPQALAPHVDLFRKHEIDGKALLLLNSDMMMKYMGLKLGPALKLCYHIDKLKQ 72

MBT

smart00561

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...

142-240

7.86e-41

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 144.31 E-value: 7.86e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  142 PMFLLKTlnGSEMASATLFKKePPKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDS 221
Cdd:smart00561   1 EDYLEET--GARAAPVELFKQ-PVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDKYDFWCHADS 77

                           90
                   ....*....|....*....
gi 2462628021  222 RDIFPAGWCRLTGDVLQPP 240
Cdd:smart00561  78 PDIFPVGWCEKNGHPLQPP 96

MBT

smart00561

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...

36-131

4.60e-39

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 139.31 E-value: 4.60e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021   36 EEYLKETGSISAPSECFRQSQIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDI 115
Cdd:smart00561   1 EDYLEETGARAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDKYDFWCHADSPDI 80

                           90
                   ....*....|....*.
gi 2462628021  116 QPVGTCEKEGDLLQPP 131
Cdd:smart00561  81 FPVGWCEKNGHPLQPP 96

MBT

pfam02820

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...

176-240

2.29e-32

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear proteins such as drosophila sex comb on midleg protein. The repeat is found in up to four copies as in Swiss:Q9UHJ3. The repeat contains a completely conserved glutamate at its amino terminus that may be important for function.

Pssm-ID: 460712 Cd Length: 66 Bit Score: 119.15 E-value: 2.29e-32

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462628021 176 MKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDSYDFWCHADSPDIHPVGWCEKNGHPLQPP 65

MBT

pfam02820

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...

67-132

5.33e-28

Pssm-ID: 460712 Cd Length: 66 Bit Score: 106.83 E-value: 5.33e-28

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462628021  67 MKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPL 132
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDSYDFWCHADSPDIHPVGWCEKNGHPLQPPK 66

SAM_1

pfam00536

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...

629-695

6.76e-14

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains.

Pssm-ID: 425739 Cd Length: 64 Bit Score: 66.91 E-value: 6.76e-14

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462628021 629 STWSVDEVIQFMKHTDPqisGPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLK 695
Cdd:pfam00536   1 DGWSVEDVGEWLESIGL---GQYIDSFRAGYIDGDALLQLTEDDLLKLGVTLLGHRKKILYAIQRLK 64

RBR

pfam17208

RNA binding Region;

277-324

1.38e-13

RNA binding Region;

Pssm-ID: 465382 [Multi-domain] Cd Length: 56 Bit Score: 65.47 E-value: 1.38e-13

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462628021 277 TQQVRRSSRIKPPGPTAVPKRSSSVKNI--------TPRKKGPNSGKKEKPLPVIC 324
Cdd:pfam17208   1 GQRGRKPGRGKPPGSTSAPKKGSSPKNApakkepikIPKKRGPKPGSKRKPRPVLS 56

SAM

smart00454

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...

628-696

1.43e-12

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation.

Pssm-ID: 197735 Cd Length: 68 Bit Score: 63.08 E-value: 1.43e-12

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  628 PSTWSVDEVIQFMKHTDPQisgPLADLFRQHEIDGKALFLLKSDVMMKYMG-LKLGPALKLCYYIEKLKE 696
Cdd:smart00454   1 VSQWSPESVADWLESIGLE---QYADNFRKNGIDGALLLLLTSEEDLKELGiTKLGHRKKILKAIQKLKE 67

Name

Accession

Description

Interval

E-value

MBT_SCMH1_rpt1

cd20105

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...

33-162

3.26e-77

Pssm-ID: 439095 Cd Length: 131 Bit Score: 243.36 E-value: 3.26e-77

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  33 FHWEEYLKETGSISAPSECFRQSQIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDS 112
Cdd:cd20105     2 FSWDKYLKETGAVPAPVHCFKQSYTPPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLVDS 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462628021 113 PDIQPVGTCEKEGDLLQPPLGYQMNTSSWPMFLLKTLNGSEMASATLFKK 162
Cdd:cd20105    82 SEIQPIGNCEKNGGMLQPPLGFRLNASSWPMFLLKTLNGAEMAPVRIFHK 131

MBT_SCML2_rpt1

cd20106

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb ...

54-151

4.57e-70

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb on midleg-like protein 2 (SCML2) is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. SCML2 contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439096 Cd Length: 98 Bit Score: 223.26 E-value: 4.57e-70

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  54 QSQIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLG 133
Cdd:cd20106     1 QSRIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPIGTCEKEGDMLQPPLG 80

                          90
                  ....*....|....*...
gi 2462628021 134 YQMNTSSWPMFLLKTLNG 151
Cdd:cd20106    81 FQMNASSWPMFLLRTLNG 98

MBT_dScm-like_rpt1

cd20091

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb ...

54-150

9.95e-66

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439081 Cd Length: 97 Bit Score: 211.78 E-value: 9.95e-66

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  54 QSQIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLG 133
Cdd:cd20091     1 QSPIPPVNEFKVGMKLEAQDPRNLTSTCIATVVGIQGPRLRLRLDGSDNKNDFWRLVDSSDIHPVGWCEKNGGLLQPPLG 80

                          90
                  ....*....|....*..
gi 2462628021 134 YQMNTSSWPMFLLKTLN 150
Cdd:cd20091    81 FRMNPSSWPMFLQKTLN 97

MBT_dScm_rpt1

cd20107

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex ...

54-150

3.97e-55

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg and similar proteins; Sex comb on midleg (Scm) is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439097 Cd Length: 99 Bit Score: 183.59 E-value: 3.97e-55

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  54 QSQIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLG 133
Cdd:cd20107     1 QAQNPPKNEFKIGMKLEALDPRNVTSTCIATVVGVLGPRLRLRLDGSDNKNDFWRLVDSTEIHPIGHCEKNGGMLQPPLG 80

                          90
                  ....*....|....*..
gi 2462628021 134 YQMNTSSWPMFLLKTLN 150
Cdd:cd20107    81 FRMNASSWPMFLLKTLN 97

MBT_SCML2_rpt2

cd20109

second malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2 (SCML2) ...

167-243

1.35e-53

Pssm-ID: 439099 Cd Length: 77 Bit Score: 178.54 E-value: 1.35e-53

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462628021 167 PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGTS 243
Cdd:cd20109     1 PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVFITFDGWRGAFDYWCKYDSRDIFPVGWCRLTGDVLQPPGNS 77

MBT_dScm-like_rpt2

cd20092

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg ...

167-241

1.07e-51

second malignant brain tumor (MBT) repeat found in the Polycomb protein sex comb on midleg family; The Sex comb on midleg (Scm) family of Polycomb proteins includes Drosophila melanogaster Scm protein, as well as two vertebrate homologs of Scm, Polycomb protein sex comb on midleg homolog 1 (SCMH1) and sex comb on midleg-like protein 2 (SCML2). Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Both SCMH1 and SCML2 are components of PRC1, which acts as an E3 ubiquitin ligase both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. SCML2 is a germline-specific Polycomb protein that acts as a critical regulator of heterochromatin organization in spermatogenesis. Members of this family contain two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439082 Cd Length: 75 Bit Score: 173.31 E-value: 1.07e-51

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462628021 167 PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPG 241
Cdd:cd20092     1 PEKNMFKVGMKLEAVDRKNPQLICPATVGDVDGDEIHISFDGWRGAFDYWCRYDSRDIFPVGWCKKTGHPLQPPG 75

SLED

pfam12140

SLED domain; The SLED (Scm-Like Embedded Domain) domain is a double-stranded DNA binding ...

356-465

2.83e-51

Pssm-ID: 463469 Cd Length: 112 Bit Score: 173.54 E-value: 2.83e-51

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021 356 TVCVYVNKHGNFGPHLDPKRIQQLPDHFGPGPVNVVLRRIVQACVDCALETKTVFGYLKPDNRG-GEVITASFDGETHSI 434
Cdd:pfam12140   1 TVCIYVNKNCFCGPHLDKKKIAELPDQFGPGPVSLVLKEVLQALIDCAYDPKQVLKLLKSGNGGrEEIITAKYEGKTHTV 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462628021 435 QLPPVNSASFALRFLENFCHSLQ-CDNLLSSQ 465
Cdd:pfam12140  81 KLPIVNSASDVWRFLEKLCEKLGcCENLFSPQ 112

SAM_Scm

cd09578

SAM domain of Scm proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm (Sex ...

625-696

2.81e-44

Pssm-ID: 188977 Cd Length: 72 Bit Score: 152.96 E-value: 2.81e-44

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462628021 625 SKDPSTWSVDEVIQFMKHTDPQISGPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLKE 696
Cdd:cd09578     1 SKDPSTWSVEDVVQFIKEADPQALAPHVDLFRKHEIDGKALLLLNSDMMMKYMGLKLGPALKLCYHIDKLKQ 72

MBT_dScm_rpt2

cd20110

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

167-241

5.26e-44

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex comb on midleg (Scm) and similar proteins; Scm is a putative zinc finger protein that functions as a transcriptional regulator which represses multiple homeotic genes during embryonic stages. It coordinates Polycomb group (PcG) complexes, PRC1 (PcG-repressive complex 1) or PRC2 (PcG-repressive complex 2), and polymerizes to produce broad domains of PcG silencing. Scm contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439100 Cd Length: 75 Bit Score: 152.22 E-value: 5.26e-44

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462628021 167 PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPG 241
Cdd:cd20110     1 PESNLFKVGMKLEAVDRKNPHLICPATVGAVKDDQIFVTFDGWRGAFDYWCRYDSRDIFPVGWCARSGHPLQPPG 75

MBT_SCMH1_rpt2

cd20108

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...

167-241

1.42e-43

second malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog 1 (SCMH1) and similar proteins; SCMH1 is a homolog of Drosophila Sex comb on midleg (Scm). It is a component of PRC1 (Polycomb repressive complex 1), which acts as an E3 ubiquitin ligase, both for histone H2A to silence transcription and for geminin to regulate its stability. SCMH1 provides the complex with an interaction domain for geminin. It contains two MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439098 Cd Length: 75 Bit Score: 150.86 E-value: 1.42e-43

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462628021 167 PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPG 241
Cdd:cd20108     1 PSQNFFKTGMKLEAVDRKNPHFICPATIGEVRGSEVLVTFDGWRGAFDYWCRYDSRDIFPVGWCSLTGDNLQPPG 75

MBT

smart00561

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...

142-240

7.86e-41

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 144.31 E-value: 7.86e-41

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  142 PMFLLKTlnGSEMASATLFKKePPKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDS 221
Cdd:smart00561   1 EDYLEET--GARAAPVELFKQ-PVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDKYDFWCHADS 77

                           90
                   ....*....|....*....
gi 2462628021  222 RDIFPAGWCRLTGDVLQPP 240
Cdd:smart00561  78 PDIFPVGWCEKNGHPLQPP 96

MBT

smart00561

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, ...

36-131

4.60e-39

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2. These proteins are involved in transcriptional regulation.

Pssm-ID: 214723 Cd Length: 96 Bit Score: 139.31 E-value: 4.60e-39

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021   36 EEYLKETGSISAPSECFRQSQIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDI 115
Cdd:smart00561   1 EDYLEETGARAAPVELFKQPVDSPPNGFKVGMKLEAVDPRNPSLICVATVVEVKGYRLLLHFDGWDDKYDFWCHADSPDI 80

                           90
                   ....*....|....*.
gi 2462628021  116 QPVGTCEKEGDLLQPP 131
Cdd:smart00561  81 FPVGWCEKNGHPLQPP 96

MBT_L3MBTL1-like_rpt2

cd20102

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...

170-240

2.96e-33

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439092 Cd Length: 90 Bit Score: 122.74 E-value: 2.96e-33

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462628021 170 NNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20102     2 HGFRVGMKLEAVDRKNPSLICVATVTDVIGNRFLVHFDGWDDSYDYWCDPDSPYIHPVGWCEENGKTLQPP 72

MBT

pfam02820

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...

176-240

2.29e-32

Pssm-ID: 460712 Cd Length: 66 Bit Score: 119.15 E-value: 2.29e-32

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462628021 176 MKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDSYDFWCHADSPDIHPVGWCEKNGHPLQPP 65

SAM_Polycomb

cd09509

SAM domain of Polycomb group; SAM (sterile alpha motif) domain of Polycomb group is a ...

628-693

3.00e-30

SAM domain of Polycomb group; SAM (sterile alpha motif) domain of Polycomb group is a protein-protein interaction domain. The Polycomb group includes transcriptional repressors which are involved in the regulation of some key regulatory genes during development in many organisms. They are best known for silencing Hox (Homeobox) genes. Polycomb proteins work together in large multimeric and chromatin-associated complexes. They organize chromatin of the target genes and maintain repressed states during many cell divisions. Polycomb proteins are classified based on their common function, but not on conserved domains and/or motifs; however many Polycomb proteins (members of PRC1 class complex) contain SAM domains which are more similar to each other inside of the Polycomb group than to SAM domains outside of it. Most information about structure and function of Polycomb SAM domains comes from studies of Ph (Polyhomeotic) and Scm (Sex comb on midleg) proteins. Polycomb SAM domains usually can be found at the C-terminus of the proteins. Some members of this group contain, in addition to the SAM domain, MTB repeats, Zn finger, and/or DUF3588 domains. Polycomb SAM domains can form homo- and/or heterooligomers through ML and EH surfaces. SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome. Polycomb proteins are known to be highly expressed in some cells years before their cancer pathology; thus they are attractive markers for early cancer therapy.

Pssm-ID: 188908 Cd Length: 64 Bit Score: 113.34 E-value: 3.00e-30

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462628021 628 PSTWSVDEVIQFMKHTDpqISGPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEK 693
Cdd:cd09509     1 PSKWSVDDVAQFIKSLD--GCAEYAEVFREQEIDGQALLLLTEDDLLKGMGLKLGPALKIYNHIVK 64

MBT_dSfmbt-like_rpt4

cd20100

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...

170-240

3.39e-28

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439090 Cd Length: 71 Bit Score: 107.76 E-value: 3.39e-28

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462628021 170 NNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20100     1 HGFKVGMKLEAVDLMEPRLICVATVTRVVGRLLRVHFDGWDDEFDQWVDCDSPDIYPVGWCELVGYPLQPP 71

MBT

pfam02820

mbt repeat; The function of this repeat is unknown, but is found in a number of nuclear ...

67-132

5.33e-28

Pssm-ID: 460712 Cd Length: 66 Bit Score: 106.83 E-value: 5.33e-28

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462628021  67 MKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPL 132
Cdd:pfam02820   1 MKLEAVDPLNPSLICVATVVKVLGGRLRLRFDGWDDSYDFWCHADSPDIHPVGWCEKNGHPLQPPK 66

MBT_L3MBTL1-like_rpt1

cd20101

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...

167-240

2.44e-27

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439091 Cd Length: 101 Bit Score: 106.20 E-value: 2.44e-27

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462628021 167 PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20101     1 FNKNGFKVGMKLEGIDPKHPSLFCVLSVAEVRGYRLRLHFDGYSECYDFWVNADSPDIFPVGWCEKTGHKLQPP 74

MBT_L3MBTL1-like_rpt1

cd20101

first malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...

61-160

5.85e-27

Pssm-ID: 439091 Cd Length: 101 Bit Score: 105.04 E-value: 5.85e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  61 NDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMNTSS 140
Cdd:cd20101     4 NGFKVGMKLEGIDPKHPSLFCVLSVAEVRGYRLRLHFDGYSECYDFWVNADSPDIFPVGWCEKTGHKLQPPKGYTSETFS 83

                          90       100
                  ....*....|....*....|
gi 2462628021 141 WPMFLLKTlnGSEMASATLF 160
Cdd:cd20101    84 WSAYLKLT--KAQAAPKHLF 101

MBT_L3MBTL1-like_rpt3

cd20103

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...

172-240

4.58e-26

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)-like family; The L3MBTL1-like family includes L3MBTL1, L3MBTL3, and L3MBTL4. L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a PcG protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a PcG protein that may act as a tumor suppressor. Members of this family contain three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439093 Cd Length: 73 Bit Score: 101.59 E-value: 4.58e-26

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20103     5 FEVGMKLEAVDKRNPRLIRVATVADVEDYRVKLHFDGWPDIYDFWVDDDSPDIHPPGWCSKTGHPLEPP 73

MBT_L3MBTL1-like_rpt2

cd20102

second malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...

61-148

5.29e-25

Pssm-ID: 439092 Cd Length: 90 Bit Score: 99.24 E-value: 5.29e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  61 NDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMNTSS 140
Cdd:cd20102     2 HGFRVGMKLEAVDRKNPSLICVATVTDVIGNRFLVHFDGWDDSYDYWCDPDSPYIHPVGWCEENGKTLQPPKGYSPGNFS 81


                  ....*...
gi 2462628021 141 WPMFLLKT 148
Cdd:cd20102    82 WDKYLEET 89

MBT_L3MBTL3_rpt1

cd20132

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

61-160

1.03e-24

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439122 Cd Length: 101 Bit Score: 98.84 E-value: 1.03e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  61 NDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMNTSS 140
Cdd:cd20132     4 NGFKVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRLHFDGYSDCYDFWVNADSPDIHPVGWCEKTGHKLHPPKGYKEEEFN 83

                          90       100
                  ....*....|....*....|
gi 2462628021 141 WPMFLlkTLNGSEMASATLF 160
Cdd:cd20132    84 WQSYL--KTCKAQAAPKSLF 101

MBT_L3MBTL1_rpt3

cd20137

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

168-240

1.56e-24

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439127 Cd Length: 75 Bit Score: 97.20 E-value: 1.56e-24

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462628021 168 PLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20137     1 PPHGFQVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPP 73

MBT

cd20088

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...

172-231

2.78e-24

Pssm-ID: 439080 Cd Length: 61 Bit Score: 96.17 E-value: 2.78e-24

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWS-GAFDYWCKYDSRDIFPAGWCR 231
Cdd:cd20088     1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWDpSRYDFWCDVDSPDIHPVGWCE 61

MBT_L3MBTL4_rpt2

cd20136

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

172-262

4.94e-24

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439126 Cd Length: 92 Bit Score: 96.61 E-value: 4.94e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPgTSVPIVKNIA 251
Cdd:cd20136     5 FQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYIQPVGWCQENGRTLVAP-QGYPNPEKFS 83

                          90
                  ....*....|.
gi 2462628021 252 KTESspSEASQ 262
Cdd:cd20136    84 WTEY--LEATQ 92

MBT_L3MBTL4_rpt1

cd20133

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

61-160

1.09e-23

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439123 Cd Length: 101 Bit Score: 96.01 E-value: 1.09e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  61 NDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMNTSS 140
Cdd:cd20133     4 NGFKVGMRLEGIDPEHPSLFCVLSVAEVQGYRLRLHFDGYSECYDFWVNADSPDIHPVGWCEKTGHKLLPPKGYKDGEFN 83

                          90       100
                  ....*....|....*....|
gi 2462628021 141 WPMFlLKTLNGsEMASATLF 160
Cdd:cd20133    84 WSSY-LKTCKA-QAAPKNLF 101

MBT

cd20088

malignant brain tumor (MBT) repeat; The MBT repeat is a protein module that recognizes ...

63-122

3.97e-23

Pssm-ID: 439080 Cd Length: 61 Bit Score: 92.70 E-value: 3.97e-23

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRN-DFWRLVDSPDIQPVGTCE 122
Cdd:cd20088     1 FKVGMKLEAVDPLNPSEICVATVVKVVGGRLLLHFDGWDPSRyDFWCDVDSPDIHPVGWCE 61

MBT_L3MBTL3_rpt3

cd20138

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

160-240

5.27e-23

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439128 Cd Length: 78 Bit Score: 93.07 E-value: 5.27e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021 160 FKKEPPkpplNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQP 239
Cdd:cd20138     1 FKVKPP----HGFQKNMKLEVVDKRNPMLIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPAGWCAKTGHPLQP 76


                  .
gi 2462628021 240 P 240
Cdd:cd20138    77 P 77

MBT_dScm-like_rpt1

cd20091

first malignant brain tumor (MBT) repeat found in the sex comb on midleg family; The sex comb ...

163-240

2.63e-22

Pssm-ID: 439081 Cd Length: 97 Bit Score: 91.98 E-value: 2.63e-22

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462628021 163 EPPKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20091     1 QSPIPPVNEFKVGMKLEAQDPRNLTSTCIATVVGIQGPRLRLRLDGSDNKNDFWRLVDSSDIHPVGWCEKNGGLLQPP 78

MBT_L3MBTL1_rpt1

cd20131

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

52-160

2.69e-22

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains the semi-aromatic cage and may bind methylated lysine residues.

Pssm-ID: 439121 Cd Length: 109 Bit Score: 92.25 E-value: 2.69e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  52 FRQSQIPPV--NDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQ 129
Cdd:cd20131     1 FQDSQAVTHnkNGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQ 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 2462628021 130 PPLGYQMNTSSWPMFLLKTlnGSEMASATLF 160
Cdd:cd20131    81 PPKGYKEEEFSWSQYLRST--RAQAAPKHLF 109

MBT_L3MBTL4_rpt3

cd20139

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

160-243

5.60e-22

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 4 (L3MBTL4); L3MBTL4, also called L(3)mbt-like protein 4, or L3mbt-like 4, is a Polycomb group (PcG) protein that may act as a tumor suppressor. L3MBTL4 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439129 Cd Length: 82 Bit Score: 90.31 E-value: 5.60e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021 160 FKKEPPkpplNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQ- 238
Cdd:cd20139     1 FKLRPP----HGFQVNMKLEAVDKRNPILIRVATIVDKDDHRIKLHFDGWDHNYDFWVDADSPDIHPVGWCDKTGHALQv 76


                  ....*
gi 2462628021 239 PPGTS 243
Cdd:cd20139    77 PLGAS 81

MBT_L3MBTL1-like_rpt3

cd20103

third malignant brain tumor (MBT) repeat found in the Lethal(3)malignant brain tumor-like ...

59-131

2.32e-21

Pssm-ID: 439093 Cd Length: 73 Bit Score: 88.10 E-value: 2.32e-21

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462628021  59 PVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPP 131
Cdd:cd20103     1 PPHGFEVGMKLEAVDKRNPRLIRVATVADVEDYRVKLHFDGWPDIYDFWVDDDSPDIHPPGWCSKTGHPLEPP 73

MBT_L3MBTL3_rpt2

cd20135

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

172-240

5.60e-21

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3); L3MBTL3, also called L(3)mbt-like protein 3, or MBT-1, is a Polycomb group (PcG) protein that recognizes mono- and dimethylated lysine residues on histone tails. It also acts as a methyl-binding protein that binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1. L3MBTL3 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439125 Cd Length: 93 Bit Score: 87.94 E-value: 5.60e-21

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20135     6 FRVGMKLEAVDKKNPSFICVATITDMVDNRLLIHFDNWDESYDYWCDASSPYIHPVGYCQEHGRTLTTP 74

MBT_L3MBTL1_rpt2

cd20134

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

172-240

7.27e-21

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1); L3MBTL1, also called L(3)mbt-like, or L(3)mbt protein homolog, is a Polycomb group (PcG) protein that functions as a 'reader' of a network of post-translational modifications by specifically recognizing and binding mono- and dimethyllysine residues on target proteins. It acts as a chromatin compaction factor by binding mono- and dimethylated histone H1b/HIST1H1E at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condensed chromatin and repressed transcription. L3MBTL1 contains three MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439124 Cd Length: 93 Bit Score: 87.58 E-value: 7.27e-21

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20134     6 FQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPP 74

MBT_L3MBTL4_rpt2

cd20136

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

62-148

1.76e-20

Pssm-ID: 439126 Cd Length: 92 Bit Score: 86.60 E-value: 1.76e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  62 DFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGY-QMNTSS 140
Cdd:cd20136     4 EFQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYIQPVGWCQENGRTLVAPQGYpNPEKFS 83


                  ....*...
gi 2462628021 141 WPMFLLKT 148
Cdd:cd20136    84 WTEYLEAT 91

MBT_L3MBTL4_rpt1

cd20133

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

170-240

4.86e-20

Pssm-ID: 439123 Cd Length: 101 Bit Score: 85.61 E-value: 4.86e-20

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462628021 170 NNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20133     4 NGFKVGMRLEGIDPEHPSLFCVLSVAEVQGYRLRLHFDGYSECYDFWVNADSPDIHPVGWCEKTGHKLLPP 74

MBT_L3MBTL3_rpt1

cd20132

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

170-240

7.44e-20

Pssm-ID: 439122 Cd Length: 101 Bit Score: 84.97 E-value: 7.44e-20

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462628021 170 NNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20132     4 NGFKVGMKLEGVDPEHQSMYCVLTVAEVCGYRIRLHFDGYSDCYDFWVNADSPDIHPVGWCEKTGHKLHPP 74

MBT_MBTD1_rpt4

cd20129

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...

172-240

7.45e-20

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439119 Cd Length: 71 Bit Score: 83.87 E-value: 7.45e-20

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20129     3 FRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 71

SAM_Ph1,2,3

cd09577

SAM domain of Ph (polyhomeotic) proteins of Polycomb group; SAM (sterile alpha motif) domain ...

626-696

1.18e-19

SAM domain of Ph (polyhomeotic) proteins of Polycomb group; SAM (sterile alpha motif) domain of Ph (polyhomeotic) proteins of Polycomb group is a protein-protein interaction domain. Ph1,2,3 proteins are members of PRC1 complex. This complex is involved in transcriptional repression of Hox (Homeobox) cluster genes. It is recruited through methylated H3Lys27 and supports the repression state by mediating monoubiquitination of histone H2A. Proteins of the Ph1,2,3 subfamily contribute to anterior-posterior neural tissue specification during embryogenesis. Additionally, the P2 protein of zebrafish is known to be involved in epiboly and tailbud formation. SAM domains of Ph proteins may interact with each other, forming homooligomers, as well as with SAM domains of other proteins, in particular with the SAM domain of Scm (sex comb on midleg) proteins, forming heterooligomers. Homooligomers are similar to the ones formed by SAM Pointed domains of the TEL proteins. Such SAM/SAM oligomers apparently play a role in transcriptional repression through polymerization along the chromosome.

Pssm-ID: 188976 Cd Length: 69 Bit Score: 83.22 E-value: 1.18e-19

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462628021 626 KDPSTWSVDEVIQFMKHTdPQISGpLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLKE 696
Cdd:cd09577     1 SNPSKWSVEDVYEFIRSL-PGCSD-YAEEFRAQEIDGQALLLLKEDHLMSAMNIKLGPALKICAKINSLKE 69

MBT_L3MBTL2_rpt4

cd20130

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

168-240

3.23e-19

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439120 Cd Length: 75 Bit Score: 82.35 E-value: 3.23e-19

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462628021 168 PLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20130     2 PNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPP 74

MBT_L3MBTL1_rpt1

cd20131

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

170-240

4.51e-18

Pssm-ID: 439121 Cd Length: 109 Bit Score: 80.31 E-value: 4.51e-18

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462628021 170 NNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20131    12 NGFKLGMKLEGIDPQHPSMYFILTVAEVCGYRLRLHFDGYSECHDFWVNANSPDIHPAGWFEKTGHKLQPP 82

MBT_SCML2_rpt1

cd20106

first malignant brain tumor (MBT) repeat found in sex comb on midleg-like protein 2; Sex comb ...

163-240

2.55e-17

Pssm-ID: 439096 Cd Length: 98 Bit Score: 77.66 E-value: 2.55e-17

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462628021 163 EPPKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20106     1 QSRIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNKNDFWRLVDSSDIQPIGTCEKEGDMLQPP 78

MBT_L3MBTL1_rpt3

cd20137

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

59-133

3.35e-17

Pssm-ID: 439127 Cd Length: 75 Bit Score: 76.40 E-value: 3.35e-17

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462628021  59 PVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLG 133
Cdd:cd20137     1 PPHGFQVNMKLEAVDRRNPALIRVASVEDVEDHRIKIHFDGWSHGYDFWIDADHPDIHPAGWCSKTGHPLQPPLG 75

MBT_L3MBTL4_rpt3

cd20139

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

59-134

4.00e-17

Pssm-ID: 439129 Cd Length: 82 Bit Score: 76.44 E-value: 4.00e-17

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462628021  59 PVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGY 134
Cdd:cd20139     5 PPHGFQVNMKLEAVDKRNPILIRVATIVDKDDHRIKLHFDGWDHNYDFWVDADSPDIHPVGWCDKTGHALQVPLGA 80

MBT_L3MBTL3_rpt2

cd20135

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

63-148

8.30e-17

Pssm-ID: 439125 Cd Length: 93 Bit Score: 76.00 E-value: 8.30e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQ-MNTSSW 141
Cdd:cd20135     6 FRVGMKLEAVDKKNPSFICVATITDMVDNRLLIHFDNWDESYDYWCDASSPYIHPVGYCQEHGRTLTTPPGYKdPKHFSW 85


                  ....*..
gi 2462628021 142 PMFLLKT 148
Cdd:cd20135    86 EKYLEET 92

SAM_Scm-like-4MBT1,2

cd09581

SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of ...

627-700

2.21e-16

SAM domain of Scm-like-4MBT1,2 proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-4MBT1,2 (Sex comb on midleg, Malignant Brain Tumor) subfamily proteins (also known as Sfmbt1,2 proteins) is a putative protein-protein interaction domain. Proteins of this subfamily are transcriptional regulators belonging to Polycomb group. The majority of them are multidomain proteins: in addition to the C-terminal SAM domain, they contain four MBT repeats and DUF5388 domain. The MBT repeats of the human sfmbt1 protein are responsible for association with the nuclear matrix and for selective binding of H3 histone N-terminal tails, while the exact function of the SAM domain is unclear.

Pssm-ID: 188980 Cd Length: 85 Bit Score: 74.41 E-value: 2.21e-16

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462628021 627 DPSTWSVDEVIQFMKHTDpqiSGPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLKEGKYS 700
Cdd:cd09581    11 NPLFWSVDDVVRFIKSTD---CAPLAKIFKDQEIDGQALLLLTLPTVQECMELKLGPAIKLCHHIERVKVAFYE 81

MBT_SFMBT_rpt1

cd20093

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...

60-151

7.32e-16

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439083 Cd Length: 94 Bit Score: 73.46 E-value: 7.32e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  60 VNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDG--SDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMN 137
Cdd:cd20093     1 QSGFKPGMKLEVPNKNNPDTYWVATVVMTCGPLLRLRYVGyeDDRSADFWCDLSSGDVHPIGWCAQNGKPLQPPADIKEK 80

                          90
                  ....*....|....
gi 2462628021 138 TSSWPMFLLKTLNG 151
Cdd:cd20093    81 ELDWAEFLIKELTG 94

MBT_L3MBTL3_rpt3

cd20138

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

55-132

7.61e-16

Pssm-ID: 439128 Cd Length: 78 Bit Score: 72.65 E-value: 7.61e-16

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462628021  55 SQIPPVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPL 132
Cdd:cd20138     1 FKVKPPHGFQKNMKLEVVDKRNPMLIRVATVADTDDHRVKVHFDGWNNCYDYWIDADSPDIHPAGWCAKTGHPLQPPL 78

MBT_SCMH1_rpt1

cd20105

first malignant brain tumor (MBT) repeat found in Polycomb protein sex comb on midleg homolog ...

140-240

7.81e-16

Pssm-ID: 439095 Cd Length: 131 Bit Score: 74.65 E-value: 7.81e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021 140 SWPMFLLKTlnGSEMASATLFKKEPpKPPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKY 219
Cdd:cd20105     3 SWDKYLKET--GAVPAPVHCFKQSY-TPPVNEFKIGMKLEAQDPRNTTSTCIATVVGLTGARLRLRLDGSDNKNDFWRLV 79

                          90       100
                  ....*....|....*....|.
gi 2462628021 220 DSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20105    80 DSSEIQPIGNCEKNGGMLQPP 100

MBT_dSfmbt-like_rpt4

cd20100

fourth malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...

63-131

1.30e-15

Pssm-ID: 439090 Cd Length: 71 Bit Score: 71.94 E-value: 1.30e-15

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPP 131
Cdd:cd20100     3 FKVGMKLEAVDLMEPRLICVATVTRVVGRLLRVHFDGWDDEFDQWVDCDSPDIYPVGWCELVGYPLQPP 71

MBT_L3MBTL1_rpt2

cd20134

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

63-148

4.36e-15

Pssm-ID: 439124 Cd Length: 93 Bit Score: 71.02 E-value: 4.36e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGY-QMNTSSW 141
Cdd:cd20134     6 FQVGMKLEAVDRMNPSLVCVASVTDVVDSRFLVHFDNWDDTYDYWCDPSSPYIHPVGWCQKQGKPLTPPQDYpDPDNFSW 85


                  ....*..
gi 2462628021 142 PMFLLKT 148
Cdd:cd20134    86 EKYLEET 92

MBT_dSfmbt_rpt4

cd20128

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

170-240

5.25e-15

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt); dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that contains the semi-aromatic cage that binds methylated lysine residues.

Pssm-ID: 439118 Cd Length: 72 Bit Score: 70.07 E-value: 5.25e-15

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462628021 170 NNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20128     1 HGFEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLDCESADIYPVGWCVLVNHKLEGP 71

MBT_dScm_rpt1

cd20107

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein sex ...

167-240

5.70e-15

Pssm-ID: 439097 Cd Length: 99 Bit Score: 71.11 E-value: 5.70e-15

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462628021 167 PPLNNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20107     5 PPKNEFKIGMKLEALDPRNVTSTCIATVVGVLGPRLRLRLDGSDNKNDFWRLVDSTEIHPIGHCEKNGGMLQPP 78

SAM_Atherin-like

cd09583

SAM domain of Atherin/Atherin-like subfamily; SAM (sterile alpha motif) domain of SAM_Atherin ...

628-694

9.47e-15

SAM domain of Atherin/Atherin-like subfamily; SAM (sterile alpha motif) domain of SAM_Atherin and Atherin-like subfamily proteins is a putative protein-protein and/or protein-lipid interaction domain. In addition to the C-terminal SAM domain, the majority of proteins belonging to this group also have PHD (or Zn finger) domain. As potential members of the polycomb group, these proteins may be involved in regulation of some key regulatory genes during development. Atherin can be recruited by Ruk/CIN85 kinase-binding proteins via its SH3 domains thus participating in the signal transferring kinase cascades. Also, atherin was found associated with low density lipids (LDL) in atherosclerotic lesions in human. It was suggested that atherin plays an essential role in atherogenesis via immobilization of LDL in the arterial wall. SAM domains of atherins are predicted to form polymers. Inhibition of polymer formation could be a potential antiatherosclerotic therapy.

Pssm-ID: 188982 Cd Length: 69 Bit Score: 69.22 E-value: 9.47e-15

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628021 628 PSTWSVDEVIQFMKHTD-PQisgpLADLFRQHEIDGKALFLLK-SDVMMKyMGLKLGPALKLCYYIEKL 694
Cdd:cd09583     1 PSNWSVEDVVQYFKTAGfPE----EANAFKEQEIDGKSLLLLTrSDVLTG-LSLKLGPALKIYEHVVKL 64

SAM_Scm-like-3MBT3,4

cd09582

SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group; SAM (sterile alpha motif) domain of ...

628-687

1.56e-14

SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-3MBT3,4 (Sex comb on midleg, Malignant brain tumor) subfamily proteins (also known as L3mbtl3,4 proteins) is a putative protein-protein interaction domain. Proteins of this subfamily are predicted transcriptional regulators belonging to Polycomb group. The majority of them are multidomain proteins: in addition to the C-terminal SAM domain, they contain three MBT repeats and Zn finger domain. Murine L3mbtl3 protein of this subfamily is essential for maturation of myeloid progenitor cells during differentiation. Human L3mbtl4 is a potential tumor suppressor gene in breast cancer, while deregulation of L3MBTL3 is associated with neuroblastoma.

Pssm-ID: 188981 Cd Length: 66 Bit Score: 68.46 E-value: 1.56e-14

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021 628 PSTWSVDEVIQFMkHTDPQiSGPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKL 687
Cdd:cd09582     1 VLRWSVDEVAEFV-QSLPG-CEEHAKVFRDEQIDGEAFLLLTQSDLVKILGIKLGPALKI 58

MBT_dSfmbt-like_rpt3

cd20099

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...

63-148

3.45e-14

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439089 [Multi-domain] Cd Length: 91 Bit Score: 68.48 E-value: 3.45e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITgaR---LRLRLDG---SDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQM 136
Cdd:cd20099     1 FKVGMKLEAVDPLNLSSICVATVRKVL--RfgyLVIGIDGpsaDDGSDWFCCHASSPFIFPVGFAEKNGIELTPPRGYES 78

                          90
                  ....*....|..
gi 2462628021 137 NTSSWPMFLLKT 148
Cdd:cd20099    79 KPFDWEEYLEET 90

MBT_SFMBT_rpt4

cd20096

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...

172-240

4.48e-14

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439086 Cd Length: 73 Bit Score: 67.65 E-value: 4.48e-14

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSG-AFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20096     1 FERGMKLEAVNPENPNQICVATITKVVGPLLWLHLDSEKKlSPNIIVDVESTDIFPVGWCESNGYPLVTP 70

MBT_MBTD1_rpt4

cd20129

fourth malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...

63-131

5.99e-14

Pssm-ID: 439119 Cd Length: 71 Bit Score: 67.31 E-value: 5.99e-14

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPP 131
Cdd:cd20129     3 FRVGMKLEAVDLMEPRLVCVATVTRIIHRLLRIHFDGWEDEYDQWVDCESPDLYPVGWCQLTGYQLQPP 71

MBT_SFMBT2_rpt1

cd20112

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...

61-151

6.29e-14

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439102 Cd Length: 94 Bit Score: 67.70 E-value: 6.29e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  61 NDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDG--SDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMNT 138
Cdd:cd20112     2 SSFQPGMKLEVANKSNPDTYWVATIITTCGQLLLLRYCGygDDRRADFWCDVMTADLHPVGWCTQNNKVLMPPDAIKEKY 81

                          90
                  ....*....|...
gi 2462628021 139 SSWPMFLLKTLNG 151
Cdd:cd20112    82 TDWTEFLIHDLTG 94

MBT_dSfmbt-like_rpt2

cd20098

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...

172-234

6.39e-14

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439088 Cd Length: 83 Bit Score: 67.27 E-value: 6.39e-14

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVHIT-FDGWSGAFDYWCKYDSRDIFPAGWCRLTG 234
Cdd:cd20098    15 FKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQyVDSEDDDDDFWCHMKSPLIHPVGWSQAVG 78

SAM_1

pfam00536

SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ...

629-695

6.76e-14

Pssm-ID: 425739 Cd Length: 64 Bit Score: 66.91 E-value: 6.76e-14

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462628021 629 STWSVDEVIQFMKHTDPqisGPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLK 695
Cdd:pfam00536   1 DGWSVEDVGEWLESIGL---GQYIDSFRAGYIDGDALLQLTEDDLLKLGVTLLGHRKKILYAIQRLK 64

MBT_SFMBT_rpt4

cd20096

fourth malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...

63-134

1.02e-13

Pssm-ID: 439086 Cd Length: 73 Bit Score: 66.49 E-value: 1.02e-13

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWrLVD--SPDIQPVGTCEKEGDLLQPPLGY 134
Cdd:cd20096     1 FERGMKLEAVNPENPNQICVATITKVVGPLLWLHLDSEKKLSPNI-IVDveSTDIFPVGWCESNGYPLVTPRKY 73

MBT_L3MBTL2_rpt4

cd20130

fourth malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

59-132

1.36e-13

Pssm-ID: 439120 Cd Length: 75 Bit Score: 66.17 E-value: 1.36e-13

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462628021  59 PVNDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPL 132
Cdd:cd20130     2 PNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDSEYDQWVDCESPDIYPVGWCELTGYQLQPPV 75

RBR

pfam17208

RNA binding Region;

277-324

1.38e-13

RNA binding Region;

Pssm-ID: 465382 [Multi-domain] Cd Length: 56 Bit Score: 65.47 E-value: 1.38e-13

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462628021 277 TQQVRRSSRIKPPGPTAVPKRSSSVKNI--------TPRKKGPNSGKKEKPLPVIC 324
Cdd:pfam17208   1 GQRGRKPGRGKPPGSTSAPKKGSSPKNApakkepikIPKKRGPKPGSKRKPRPVLS 56

MBT_SFMBT1_rpt1

cd20111

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...

61-151

1.43e-13

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439101 Cd Length: 94 Bit Score: 66.78 E-value: 1.43e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  61 NDFKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDG--SDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMNT 138
Cdd:cd20111     2 NGFSPGMKLEVAVRTDPNTYWVATIITTCGQLLLLRYDGygEDRRADFWCDIMTADLHPIGWCEQNGKTLRPPEGIRDKL 81

                          90
                  ....*....|...
gi 2462628021 139 SSWPMFLLKTLNG 151
Cdd:cd20111    82 SDWEEFLAQTLTG 94

SAM_Scm-like-4MBT

cd09580

SAM domain of Scm-like-4MBT proteins of Polycomb group; SAM (sterile alpha motif) domain of ...

628-695

3.19e-13

SAM domain of Scm-like-4MBT proteins of Polycomb group; SAM (sterile alpha motif) domain of Scm-like-4MBT (Sex comb on midleg like, Malignant Brain Tumor) subfamily proteins of the polycomb group is a putative protein-protein interaction domain. Additionally to the SAM domain, most of the proteins of this subfamily have 4 MBT repeats. In Drosophila SAM-Scm-like-4MBT protein (known as dSfmbt) is a member of Pho repressive complex (PhoRC). Additionally to dSfmbt, the PhoRC complex includes Pho or Pho-like proteins. This complex is responsible for HOX (Homeobox) gene silencing: Pho or Pho-like proteins bind DNA and dSmbt binds methylated histones. dSmbt can interact with mono- and di-methylated histones H3 and H4 (however this activity has been shown for the MBT repeats, while exact function of the SAM domain is unclear). Besides interaction with histones, dSmbt can interact with Scm (a member of PRC complex), but this interaction also seems to be SAM domain independent.

Pssm-ID: 188979 Cd Length: 67 Bit Score: 65.08 E-value: 3.19e-13

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462628021 628 PSTWSVDEVIQFMKHTDpqiSGPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKLCYYIEKLK 695
Cdd:cd09580     1 PSTWGVKDVSQFLREND---CGAYCECFCRQNIDGKRLLSLTKEQIMTLTGMKVGPSLKIYDLIQQLK 65

MBT_L3MBTL2_rpt3

cd20127

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

63-148

3.88e-13

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439117 Cd Length: 91 Bit Score: 65.62 E-value: 3.88e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATV----------IGITGARLRlrlDGSDNrndFWRLVDSPDIQPVGTCEKEGDLLQPPL 132
Cdd:cd20127     1 FEEGMKLEAIDPLNLGNICVATVckvlldgylmIGIDGGPST---DGSDW---FCYHASSHAIFPVGFCQKNDIELTPPK 74

                          90
                  ....*....|....*.
gi 2462628021 133 GYQMNTSSWPMFLLKT 148
Cdd:cd20127    75 GYDAQTFNWENYLEKT 90

MBT_dSfmbt-like_rpt2

cd20098

second malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb ...

63-119

1.20e-12

Pssm-ID: 439088 Cd Length: 83 Bit Score: 63.81 E-value: 1.20e-12

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGARLRLR-LDGSDNRNDFWRLVDSPDIQPVG 119
Cdd:cd20098    15 FKVGMRLEVVDKMCISRTRVAVVEEVVGGRLRLQyVDSEDDDDDFWCHMKSPLIHPVG 72

SAM

smart00454

Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ...

628-696

1.43e-12

Pssm-ID: 197735 Cd Length: 68 Bit Score: 63.08 E-value: 1.43e-12

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  628 PSTWSVDEVIQFMKHTDPQisgPLADLFRQHEIDGKALFLLKSDVMMKYMG-LKLGPALKLCYYIEKLKE 696
Cdd:smart00454   1 VSQWSPESVADWLESIGLE---QYADNFRKNGIDGALLLLLTSEEDLKELGiTKLGHRKKILKAIQKLKE 67

MBT_MBTD1_rpt3

cd20126

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...

63-148

1.59e-12

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439116 Cd Length: 90 Bit Score: 63.65 E-value: 1.59e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATV----------IGITGArlrLRLDGSDNrndFWRLVDSPDIQPVGTCEKEGDLLQPPL 132
Cdd:cd20126     1 FKEGMKLEAIDPLNLSTICVATVrkvlangylmIGIDGS---EAADGSDW---FCYHATSPSIFPVGFCEINMIELTPPR 74

                          90
                  ....*....|....*.
gi 2462628021 133 GYQmNTSSWPMFLLKT 148
Cdd:cd20126    75 GYK-KPFKWFDYLRET 89

MBT_SFMBT_rpt1

cd20093

first malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...

170-240

3.78e-12

Pssm-ID: 439083 Cd Length: 94 Bit Score: 62.68 E-value: 3.78e-12

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462628021 170 NNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGW--SGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20093     2 SGFKPGMKLEVPNKNNPDTYWVATVVMTCGPLLRLRYVGYedDRSADFWCDLSSGDVHPIGWCAQNGKPLQPP 74

MBT_dSfmbt_rpt1

cd20119

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

65-152

5.54e-12

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439109 Cd Length: 104 Bit Score: 62.46 E-value: 5.54e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  65 VGMKLE-----ARDPRNATSVCIATVIGITGARLRLRLDG--SDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMN 137
Cdd:cd20119     6 VGMKVEventdTDLIEDPTSFWIATVLKIAGYKALMRYEGfgTDDSKDFWVNLCSEDVHPVGWCATRGKPLIPPRTIEHK 85

                          90
                  ....*....|....*
gi 2462628021 138 TSSWPMFLLKTLNGS 152
Cdd:cd20119    86 YSDWKEFLVKRLTGA 100

MBT_MBTD1_rpt1

cd20120

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...

62-153

5.56e-12

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439110 Cd Length: 103 Bit Score: 62.56 E-value: 5.56e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  62 DFKVGMKLEA--RDPRNATSV-CIATVIGITGARLRLRLDG--SDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQM 136
Cdd:cd20120     3 DIAEGVRVEVpnTDCNLPTKVfWIAGIVKLAGYKALLRYEGfeNDSSLDFWCNICGSDIHPVGWCATSGKPLVPPKTIQH 82

                          90
                  ....*....|....*..
gi 2462628021 137 NTSSWPMFLLKTLNGSE 153
Cdd:cd20120    83 KYTNWKAFLVKRLTGAK 99

MBT_SFMBT_rpt2

cd20094

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...

63-145

1.10e-11

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439084 Cd Length: 91 Bit Score: 61.48 E-value: 1.10e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRN--DFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQM--NT 138
Cdd:cd20094     4 IKVGMYLEVQDELNPYSVWIAKVLENVGGRLLLRYDGPEDSDspDFWLFYLSPRLHPLGWAKSNGYTYRPPKSLEKlhAT 83


                  ....*..
gi 2462628021 139 SSWPMFL 145
Cdd:cd20094    84 EEWKAIL 90

MBT_dSfmbt_rpt3

cd20125

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

63-165

3.45e-11

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439115 Cd Length: 107 Bit Score: 60.64 E-value: 3.45e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGI-TGARLRLRLDGSDNRND----FWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMN 137
Cdd:cd20125     1 FKEGMKLEAVDPLNLSAICVATVMKVlRFGYLMIRIDSYEPDASgsdwFCYHESSPCIFPAGFCEVNNITLTPPNGYDGR 80

                          90       100
                  ....*....|....*....|....*...
gi 2462628021 138 TSSWPMFLLKtlNGSEMASATLFKKEPP 165
Cdd:cd20125    81 TFTWEGYLRQ--TGATAAPQHLFHRIIP 106

MBT_SFMBT_rpt3

cd20095

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...

172-240

4.03e-11

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein (SFMBT) family; The SFMBT family includes SFMBT1 and SFMBT2. SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439085 Cd Length: 92 Bit Score: 59.58 E-value: 4.03e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGDE-VHITFD----GWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20095     1 FKVGMKLEALHPKNPSTICPATVTKVFNEYyFLVEIDdlrpEESEKITFVCHANSPGIFPVGWCAKNGLRLTPP 74

MBT_SFMBT2_rpt4

cd20118

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...

63-132

1.27e-10

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439108 Cd Length: 91 Bit Score: 58.30 E-value: 1.27e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDN-RNDFWRLVDSPDIQPVGTCEKEGDLLQPPL 132
Cdd:cd20118     2 FTKNMKLEAVNPRNPAEICVASITSVKGRLLWLHLEGLQNpVPEYIVDVESMDIFPVGWCEANGYPLTPPH 72

MBT_dSfmbt-like_rpt1

cd20097

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...

64-152

1.89e-10

first malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt)-like family; The dSfmbt-like family includes Drosophila melanogaster Scm-like with four MBT domain-containing protein 1 (dSfmbt), as well as its two vertebrate homologs, MBT domain-containing protein 1 (MBTD1) and Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2). dSfmbt is a Polycomb group (PcG) repressor involved in epigenetic regulation of gene expression. MBTD1 and L3MBTL2, also called L(3)mbt-like protein 2, are putative PcG proteins that specifically bind to monomethylated and dimethylated 'Lys-20' on histone H4. L3MBTL2 also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. Members of this family contain four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439087 Cd Length: 105 Bit Score: 58.47 E-value: 1.89e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  64 KVGMKLEAR---DPRNATSVC---IATVIGITGARLRLRLDGSD--NRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQ 135
Cdd:cd20097     5 KIGVKVEVAnrdDDKPTDNVKvywFARIIKVAGYRVLLRYEGYDedSSHDFWINLCSNEIHPIGYAAENGKILVPPKSIE 84

                          90
                  ....*....|....*..
gi 2462628021 136 MNTSSWPMFLLKTLNGS 152
Cdd:cd20097    85 DKENDWKEYIMKRLHGK 101

MBT_SFMBT_rpt3

cd20095

third malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...

63-145

2.14e-10

Pssm-ID: 439085 Cd Length: 92 Bit Score: 57.65 E-value: 2.14e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGAR------LRLRLDGSDNRndfwRLV---DSPDIQPVGTCEKEGDLLQPPLG 133
Cdd:cd20095     1 FKVGMKLEALHPKNPSTICPATVTKVFNEYyflveiDDLRPEESEKI----TFVchaNSPGIFPVGWCAKNGLRLTPPPG 76

                          90
                  ....*....|..
gi 2462628021 134 YQMNTSSWPMFL 145
Cdd:cd20095    77 YPKSEFDWDSYL 88

SAM_Samd7,11

cd09579

SAM domain of Samd7,11 subfamily of Polycomb group; SAM (sterile alpha motif) domain is a ...

629-687

5.52e-10

SAM domain of Samd7,11 subfamily of Polycomb group; SAM (sterile alpha motif) domain is a protein-protein interaction domain. Phylogenetic analysis suggests that proteins of this subfamily are most closely related to SAM-Ph1,2,3 subfamily of Polycomb group. They are predicted transcriptional repressors in photoreceptor cells and pinealocytes of vertebrates. SAM domain containing protein 11 is also known as Mr-s (major retinal SAM) protein. In mouse, it is predominantly expressed in developing retinal photoreceptors and in adult pineal gland. The SAM domain is involved in homooligomerization of whole proteins (it was shown based on immunoprecipitation assay and mutagenesis), however its repression activity is not due to SAM/SAM interactions but to the C-terminal region.

Pssm-ID: 188978 Cd Length: 68 Bit Score: 55.92 E-value: 5.52e-10

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628021 629 STWSVDEVIQFMKHTDpqISGPLADLFRQHEIDGKALFLLKSDVMMKYMGLKLGPALKL 687
Cdd:cd09579     2 RKWTVDDVCSFIGSLP--GCAEYAQVFREHSIDGETLPLLTEEHLLNTMGLKLGPALKI 58

MBT_SFMBT2_rpt4

cd20118

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...

172-240

1.43e-09

Pssm-ID: 439108 Cd Length: 91 Bit Score: 55.22 E-value: 1.43e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAF-DYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20118     2 FTKNMKLEAVNPRNPAEICVASITSVKGRLLWLHLEGLQNPVpEYIVDVESMDIFPVGWCEANGYPLTPP 71

MBT_MBTD1_rpt3

cd20126

third malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...

172-240

1.48e-09

Pssm-ID: 439116 Cd Length: 90 Bit Score: 55.18 E-value: 1.48e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDV-KGDEVHITFDGWSGA--FDYWCKY-DSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20126     1 FKEGMKLEAIDPLNLSTICVATVRKVlANGYLMIGIDGSEAAdgSDWFCYHaTSPSIFPVGFCEINMIELTPP 73

MBT_SFMBT1_rpt4

cd20117

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...

63-131

3.99e-09

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the fourth MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439107 Cd Length: 90 Bit Score: 54.12 E-value: 3.99e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNR-NDFWRLVDSPDIQPVGTCEKEGDLLQPP 131
Cdd:cd20117     3 FKENMKLEAVNPICPEEICVATVTKVKGSYLWLQLEGSKKPiPECIVHVESMDIFPVGWCETNGYPLLHP 72

MBT_dSfmbt_rpt3

cd20125

third malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

172-240

4.78e-09

Pssm-ID: 439115 Cd Length: 107 Bit Score: 54.47 E-value: 4.78e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDV-KGDEVHITFDGW---SGAFDYWCKYDSRD-IFPAGWCRLTGDVLQPP 240
Cdd:cd20125     1 FKEGMKLEAVDPLNLSAICVATVMKVlRFGYLMIRIDSYepdASGSDWFCYHESSPcIFPAGFCEVNNITLTPP 74

MBT_dSfmbt-like_rpt3

cd20099

third malignant brain tumor (MBT) repeat found in the Drosophila melanogaster Polycomb protein ...

172-240

6.14e-09

Pssm-ID: 439089 [Multi-domain] Cd Length: 91 Bit Score: 53.46 E-value: 6.14e-09

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVH-ITFDG---WSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20099     1 FKVGMKLEAVDPLNLSSICVATVRKVLRFGYLvIGIDGpsaDDGSDWFCCHASSPFIFPVGFAEKNGIELTPP 73

MBT_dSfmbt_rpt2

cd20122

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

63-119

1.02e-08

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein Sfmbt (dSfmbt) and similar proteins; dSfmbt, also called Scm-like with four MBT domain-containing protein 1, is a Polycomb group repressor involved in epigenetic regulation of gene expression. dSfmbt contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439112 Cd Length: 83 Bit Score: 52.54 E-value: 1.02e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRND-FWRLVDSPDIQPVG 119
Cdd:cd20122    14 FRLGLNLECVDKNRISQVRVATVTKIVGKRLHLRYEGSEPDDDgFWCHEDSPLIHPVG 71

MBT_SFMBT2_rpt1

cd20112

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...

170-240

1.28e-08

Pssm-ID: 439102 Cd Length: 94 Bit Score: 52.68 E-value: 1.28e-08

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462628021 170 NNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSG--AFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20112     2 SSFQPGMKLEVANKSNPDTYWVATIITTCGQLLLLRYCGYGDdrRADFWCDVMTADLHPVGWCTQNNKVLMPP 74

MBT_L3MBTL2_rpt1

cd20121

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

62-152

3.50e-08

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) and similar proteins; L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the first MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439111 Cd Length: 102 Bit Score: 51.77 E-value: 3.50e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  62 DFKVGMKLEARdprNATSVC------IATVIGITGARLRLRLDG--SDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLG 133
Cdd:cd20121     3 DVMEGMKVEVL---NTDAVLpsrvywIASVIQLAGYKALLRYEGfeNDSSHDFWCNLGTVDVHPIGWCAINSKILVPPQT 79

                          90
                  ....*....|....*....
gi 2462628021 134 YQMNTSSWPMFLLKTLNGS 152
Cdd:cd20121    80 IHAKFTDWRGYLMKRLVGS 98

MBT_PHF20L1-like

cd20104

malignant brain tumor (MBT) repeat found in PHD finger protein 20-like protein 1 (PHF20L1) and ...

172-226

5.01e-08

malignant brain tumor (MBT) repeat found in PHD finger protein 20-like protein 1 (PHF20L1) and similar domains; PHF20L1 associates with SOX2, antagonizes SOX2 ubiquitination and the sequential degradation induced by MLL1/WDR5 complexes. It binds both monomethylated Lys-42 and Lys-117 in SOX2 and thereby prevents SOX2 proteolysis. PHF20L1 also reads and controls enzyme levels of methylated DNMT1 in cells, thus representing a novel antagonist of DNMT1 degradation. PHF20L1 contains one MBT (malignant brain tumor) repeat. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the MBT repeat of PHF20L1 and similar domains that contains the semi-aromatic cage that may bind methylated lysine residues.

Pssm-ID: 439094 [Multi-domain] Cd Length: 60 Bit Score: 49.93 E-value: 5.01e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462628021 172 FKVGMKLEAIDKKNpyLICPATIGDV--KGDEVHITFDGWSGAFDYWCKYDSRDIFP 226
Cdd:cd20104     1 FKVGDRVDALDGEG--KWYEAKIVEVdeEENKVLVHYDGWSSRYDEWIDRDSERLRP 55

MBT_dSfmbt_rpt4

cd20128

fourth malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

63-121

9.55e-08

Pssm-ID: 439118 Cd Length: 72 Bit Score: 49.65 E-value: 9.55e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTC 121
Cdd:cd20128     3 FEVGMSLECADLMDPRLVCVATVARVVGRLLKVHFDGWTDEYDQWLDCESADIYPVGWC 61

MBT_SFMBT1_rpt4

cd20117

fourth malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...

172-240

1.25e-07

Pssm-ID: 439107 Cd Length: 90 Bit Score: 49.88 E-value: 1.25e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAF-DYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20117     3 FKENMKLEAVNPICPEEICVATVTKVKGSYLWLQLEGSKKPIpECIVHVESMDIFPVGWCETNGYPLLHP 72

MBT_SFMBT1_rpt1

cd20111

first malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...

170-240

1.52e-07

Pssm-ID: 439101 Cd Length: 94 Bit Score: 49.83 E-value: 1.52e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462628021 170 NNFKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSG--AFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20111     2 NGFSPGMKLEVAVRTDPNTYWVATIITTCGQLLLLRYDGYGEdrRADFWCDIMTADLHPIGWCEQNGKTLRPP 74

MBT_SFMBT1_rpt2

cd20113

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...

66-132

1.83e-07

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439103 Cd Length: 99 Bit Score: 49.81 E-value: 1.83e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628021  66 GMKLEARDPRNATSVCIATVIGITGARLRLRLDGSD--NRNDFWRLVDSPDIQPVGTCEKEGDLLQPPL 132
Cdd:cd20113     7 GSRLELQDFQDSLVAWIVVVVENIGGRLKLRYEGLEgsDKSDTWLFYLDPFLHQVGWAAQHGYTLQPPA 75

MBT_L3MBTL2_rpt2

cd20124

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

63-131

2.35e-07

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2); L3MBTL2, also called L(3)mbt-like protein 2, is a putative Polycomb group (PcG) protein that binds to monomethylated and dimethylated 'Lys-20' on histone H4 and also binds histone H3 peptides which are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. It is an integral component of the polycomb repressive complex 1.6 (PRC1.6) and has been implicated in transcriptional repression and chromatin compaction. L3MBTL2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439114 Cd Length: 84 Bit Score: 48.68 E-value: 2.35e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPP 131
Cdd:cd20124    14 FRQGMRVEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHSIKMS 82

MBT_dSfmbt_rpt2

cd20122

second malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

172-234

3.61e-07

Pssm-ID: 439112 Cd Length: 83 Bit Score: 48.30 E-value: 3.61e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFD-YWCKYDSRDIFPAGWCRLTG 234
Cdd:cd20122    14 FRLGLNLECVDKNRISQVRVATVTKIVGKRLHLRYEGSEPDDDgFWCHEDSPLIHPVGWAQTVG 77

MBT_SFMBT_rpt2

cd20094

second malignant brain tumor (MBT) repeat found in the Scm-like with four MBT domains protein ...

172-240

4.27e-07

Pssm-ID: 439084 Cd Length: 91 Bit Score: 48.38 E-value: 4.27e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGW--SGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20094     4 IKVGMYLEVQDELNPYSVWIAKVLENVGGRLLLRYDGPedSDSPDFWLFYLSPRLHPLGWAKSNGYTYRPP 74

MBT_SFMBT2_rpt3

cd20116

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...

172-240

5.75e-07

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439106 Cd Length: 93 Bit Score: 47.87 E-value: 5.75e-07

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGDE-VHITFDGWSGAFD---YWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20116     3 FTVGMKLEVVDPREPFHICPASVTKVFNNHyFQVTVDDLRPEASensMLCHADSLGILPVQWCLKNGVNLTPP 75

MBT_SFMBT1_rpt3

cd20115

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...

172-240

1.93e-06

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 (SFMBT1); SFMBT1, also called renal ubiquitous protein 1, is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3 and functions as a chromatin reader in regulating epigenetic silencing and the myogenic gene program. It mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. SFMBT1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the third MBT repeat that does not contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439105 Cd Length: 94 Bit Score: 46.40 E-value: 1.93e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGD-----EVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20115     3 FSEGMKLEAVDPAAPFTISPATVAKVFNEkfflvEMDDLRPEEAGAHSFVCHRDSPGIFPVQWSLKNGLHLSPP 76

MBT_MBTD1_rpt2

cd20123

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...

63-119

2.31e-05

second malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); MBTD1 is a putative Polycomb group (PcG) protein that specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4. MBTD1 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that does not seem to contain a semi-aromatic cage and may not bind methylated lysine residues.

Pssm-ID: 439113 Cd Length: 85 Bit Score: 43.41 E-value: 2.31e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRLDGSDNR-NDFWRLVDSPDIQPVG 119
Cdd:cd20123    14 FKPCMRVEVVDKTHLCRTRVAVVESVIGGRLRLVYEESEDGtDDFWCHMYSPLIHHIG 71

MBT_SFMBT2_rpt3

cd20116

three malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...

63-141

2.69e-05

Pssm-ID: 439106 Cd Length: 93 Bit Score: 43.25 E-value: 2.69e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGARL------RLRLDGSdnRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQM 136
Cdd:cd20116     3 FTVGMKLEVVDPREPFHICPASVTKVFNNHYfqvtvdDLRPEAS--ENSMLCHADSLGILPVQWCLKNGVNLTPPKGYSG 80


                  ....*
gi 2462628021 137 NTSSW 141
Cdd:cd20116    81 QDFDW 85

MBT_L3MBTL2_rpt3

cd20127

third malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

172-240

7.17e-05

Pssm-ID: 439117 Cd Length: 91 Bit Score: 42.12 E-value: 7.17e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGD-EVHITFDGWSGA--FDYWCKY-DSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20127     1 FEEGMKLEAIDPLNLGNICVATVCKVLLDgYLMIGIDGGPSTdgSDWFCYHaSSHAIFPVGFCQKNDIELTPP 73

SAM_WDSUB1

cd09505

SAM domain of WDSUB1 proteins; SAM (sterile alpha motif) domain of WDSUB1 subfamily proteins ...

628-700

1.13e-04

SAM domain of WDSUB1 proteins; SAM (sterile alpha motif) domain of WDSUB1 subfamily proteins is a putative protein-protein interaction domain. Proteins of this group contain multiple domains: SAM, one or more WD40 repeats and U-box (derived version of the RING-finger domain). Apparently the WDSUB1 subfamily proteins participate in protein degradation through ubiquitination, since U-box domain are known as a member of E3 ubiquitin ligase family, while SAM and WD40 domains most probably are responsible for an E2 ubiquitin-conjugating enzyme binding and a target protein binding.

Pssm-ID: 188904 Cd Length: 72 Bit Score: 40.76 E-value: 1.13e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462628021 628 PSTWSVDEVIQFMKHTDPQisgPLADLFRQHEIDGKALFLLKSDVMMKYMGLK-LGPALKLCYYIEKLKEGKYS 700
Cdd:cd09505     2 LQDWSEEDVCTWLRSIGLE---QYVEVFRANNIDGKELLNLTKESLSKDLKIEsLGHRNKILRKIEELKMKSDS 72

MBT_SFMBT1_rpt3

cd20115

third malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 1 ...

63-145

2.26e-04

Pssm-ID: 439105 Cd Length: 94 Bit Score: 40.62 E-value: 2.26e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  63 FKVGMKLEARDPRNATSVCIATVIGITGARLRLRL-----DGSDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLGYQMN 137
Cdd:cd20115     3 FSEGMKLEAVDPAAPFTISPATVAKVFNEKFFLVEmddlrPEEAGAHSFVCHRDSPGIFPVQWSLKNGLHLSPPPGYPGQ 82


                  ....*...
gi 2462628021 138 TSSWPMFL 145
Cdd:cd20115    83 DFDWADYL 90

MBT_dSfmbt_rpt1

cd20119

first malignant brain tumor (MBT) repeat found in Drosophila melanogaster Polycomb protein ...

171-242

2.70e-04

Pssm-ID: 439109 Cd Length: 104 Bit Score: 40.89 E-value: 2.70e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628021 171 NFKVGMKLEAIDK-----KNPYLICPATIGDVKGDEVHITFDGWSG--AFDYWCKYDSRDIFPAGWCRLTGDVLQPPGT 242
Cdd:cd20119     3 NITVGMKVEVENTdtdliEDPTSFWIATVLKIAGYKALMRYEGFGTddSKDFWVNLCSEDVHPVGWCATRGKPLIPPRT 81

SAM_superfamily

cd09487

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...

635-693

7.23e-04

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.

Pssm-ID: 188886 [Multi-domain] Cd Length: 56 Bit Score: 37.99 E-value: 7.23e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021 635 EVIQFMKHTDPqisGPLADLFRQHEIDGKALFLLkSDVMMKYMGLK-LGPALKLCYYIEK 693
Cdd:cd09487     1 DVAEWLESLGL---EQYADLFRKNEIDGDALLLL-TDEDLKELGITsPGHRKKILRAIQR 56

MBT_L3MBTL2_rpt1

cd20121

first malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

174-242

8.57e-04

Pssm-ID: 439111 Cd Length: 102 Bit Score: 39.44 E-value: 8.57e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462628021 174 VGMKLEAIDK-----KNPYLIcpATIGDVKGDEVHITFDGW--SGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGT 242
Cdd:cd20121     6 EGMKVEVLNTdavlpSRVYWI--ASVIQLAGYKALLRYEGFenDSSHDFWCNLGTVDVHPIGWCAINSKILVPPQT 79

MBT_L3MBTL2_rpt2

cd20124

second malignant brain tumor (MBT) repeat found in Lethal(3)malignant brain tumor-like protein ...

172-240

9.98e-04

Pssm-ID: 439114 Cd Length: 84 Bit Score: 38.67 E-value: 9.98e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628021 172 FKVGMKLEAIDKKNPYLICPATIGDVKGDEVHITFDGWSGAFDYWCKYDSRDIFPAGWCRLTGDVLQPP 240
Cdd:cd20124    14 FRQGMRVEVVDKSQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHSIKMS 82

MBT_MBTD1_rpt1

cd20120

first malignant brain tumor (MBT) repeat found in MBT domain-containing protein 1 (MBTD1); ...

174-242

2.42e-03

Pssm-ID: 439110 Cd Length: 103 Bit Score: 37.91 E-value: 2.42e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462628021 174 VGMKLEAIDKKNP-----YLIcpATIGDVKGDEVHITFDGW--SGAFDYWCKYDSRDIFPAGWCRLTGDVLQPPGT 242
Cdd:cd20120     6 EGVRVEVPNTDCNlptkvFWI--AGIVKLAGYKALLRYEGFenDSSLDFWCNICGSDIHPVGWCATSGKPLVPPKT 79

SAM_MLTK

cd09529

SAM domain of MLTK subfamily; SAM (sterile alpha motif) domain of MLTK subfamily is a ...

630-695

3.02e-03

SAM domain of MLTK subfamily; SAM (sterile alpha motif) domain of MLTK subfamily is a protein-protein interaction domain. Besides SAM domain, these proteins have N-terminal protein tyrosine kinase domain and leucine-zipper motif. Proteins of this group act as mitogen-activated protein triple kinase in a number of MAPK cascades. They can be activated by autophosphorylation in response to stress signals. MLTK-alpha is known to phosphorylate histone H3. In mammals, MLTKs participate in the activation of the JNK/SAPK, p38, ERK5 pathways, the transcriptional factor NF-kB, in the regulation of the cell cycle checkpoint, and in the induction of apoptosis in a hepatoma cell line. Some members of this subfamily are proto-oncogenes, thus MLTK-alpha is involved in neoplasmic cell transformation and/or skin cancer development in athymic nude mice. Based on in vivo coprecipitation experiments in mammalian cells, it has been demonstrated that MLTK proteins might form homodimers/oligomers via their SAM domains.

Pssm-ID: 188928 Cd Length: 71 Bit Score: 36.71 E-value: 3.02e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462628021 630 TWSVDEVIQFMKHTDPQISGP-----LADLFRQHEIDGKALFLLkSDVMMKYMGLK-LGPALKLCYYIEKLK 695
Cdd:cd09529     1 AWTEEDVHFWMQQLVRKGGHPselsqYADLFKENHITGKRLLLL-TEEDLRDMGIGsKGHIIHLKSAIEKLT 71

SAM_BOI-like_fungal

cd09535

SAM domain of BOI-like fungal subfamily; SAM (sterile alpha motif) domain of BOI-like fungal ...

630-695

4.29e-03

SAM domain of BOI-like fungal subfamily; SAM (sterile alpha motif) domain of BOI-like fungal subfamily is a potential protein-protein interaction domain. Proteins of this subfamily are apparently scaffold proteins, since most contain SH3 and PH domains, which are also protein-protein interaction domains, in addition to SAM domain. BOI-like proteins participate in cell cycle regulation. In particular BOI1 and BOI2 proteins of budding yeast S.cerevisiae are involved in bud formation, and POB1 protein of fission yeast S.pombe plays a role in cell elongation and separation. Among binding partners of BOI-like fungal subfamily members are such proteins as Bem1 and Cdc42 (they are known to be involved in cell polarization and bud formation).

Pssm-ID: 188934 Cd Length: 65 Bit Score: 35.99 E-value: 4.29e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462628021 630 TWSVDEVIQFMKHT--DPQIsgplADLFRQHEIDGKALFLLKSDvMMKYMGLK-LGPALKLCYYIEKLK 695
Cdd:cd09535     2 SWSPEQVAEWLLSAgfDDSV----CEKFRENEITGDILLELDLE-DLKELDIGsFGKRFKLWNEIKSLR 65

MBT_SFMBT2_rpt2

cd20114

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 ...

65-153

5.28e-03

second malignant brain tumor (MBT) repeat found in Scm-like with four MBT domains protein 2 (SFMBT2); SFMBT2, also called Scm-like with 4 MBT domains protein 2, is a transcriptional repressor of the HOXB13 gene. It is required for trophoblast maintenance and placenta development. It also negatively regulates cell migration and invasion in prostate cancer cells. SFMBT2 contains four MBT (malignant brain tumor) repeats. The MBT repeat is a protein module that recognizes methylated lysine residues on histones. MBT repeats contain a semi-aromatic cage to accommodate methyllysine and show specificity towards the lower methylation states of lysine. This model corresponds to the second MBT repeat that contains a partially conserved semi-aromatic cage.

Pssm-ID: 439104 Cd Length: 98 Bit Score: 37.01 E-value: 5.28e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462628021  65 VGMKLEARDPRNATSVCIATVIGITGARLRLRLDG-SDNRNDFWRLVDSPDIQPVGTCEKEGDLLQPPLG-YQMNTSS-W 141
Cdd:cd20114     6 VGSLIELQDSQNPFQYWIVRVIENVGGRLRLRYVGlEDESHDQWLFYLDTRLRPVGWCQENNLRMEPPTEiCDLKSASeW 85

                          90
                  ....*....|..
gi 2462628021 142 PMFLLKTLNGSE 153
Cdd:cd20114    86 KEALEKSLAEAA 97

SAM_Samd9_Samd9L

cd09528

SAM domain of Samd9/Samd9L subfamily; SAM (sterile alpha motif) domain of Samd9/Samd9L ...

631-695

7.46e-03

SAM domain of Samd9/Samd9L subfamily; SAM (sterile alpha motif) domain of Samd9/Samd9L subfamily is a putative protein-protein interaction domain. SAM is a widespread domain in signaling proteins. Samd9 is a tumor suppressor gene. It is involved in death signaling of malignant glioblastoma. Samd9 suppression blocks cancer cell death induced by HVJ-E or IFN-beta treatment. Deleterious mutations in Samd9 lead to normophosphatemic familial tumoral calcinosis, a cutaneous disorder characterized by cutaneous calcification or ossification.

Pssm-ID: 188927 Cd Length: 64 Bit Score: 35.47 E-value: 7.46e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462628021 631 WSVDEVIQFMkhTDPQISGPLADLFRQHEIDGKALFLL-KSDvmMKYMGLKLGPALKLCYYIEKLK 695
Cdd:cd09528     3 WTKEHVKQWL--IEDLIDKKYAEILYEEEVTGAVLKELtEED--LVDMGLPHGPALLIIHSFNELN 64

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01