|
Name |
Accession |
Description |
Interval |
E-value |
| ES |
cd16159 |
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ... |
46-382 |
8.08e-163 |
|
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.
Pssm-ID: 293778 [Multi-domain] Cd Length: 521 Bit Score: 467.92 E-value: 8.08e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 46 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWT 125
Cdd:cd16159 1 KPNIVLFMADDLGIGDVGCFGNDTIRTPNIDRLAKEGVKLTHHLAAAPLCTPSRAAFLTGRYPIRSGMASSHGMRVILFT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 126 GASGGLPTNETTFAKILKEKGYATGLI----------------------------------------------------- 152
Cdd:cd16159 81 ASSGGLPPNETTFAEVLKQQGYSTALIgkwhlglhcesrndfchhplnhgfdyfyglpltnlkdcgdgsngeydlsfdpl 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 --------------------------------------------------------------------------------
Cdd:cd16159 161 fplltafvlitaltiflllylgavskrffvfllilsllfislfflllitnryfncilmrnhevveqpmslenltqrltke 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 153 ----------------------------------------------------GRILDTLDVEGLSNSTLIYFTSDHGGSL 180
Cdd:cd16159 241 aisflernkerpfllvmsflhvhtalftskkfkgrskhgrygdnveemdwsvGQILDALDELGLKDNTFVYFTSDNGGHL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 181 ENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGSEVPQDRVIDGQDLL 260
Cdd:cd16159 321 EEISVGGEYGGGNGGIYGGKKMGGWEGGIRVPTIVRWPGVIPPGSVIDEPTSLMDIFPTVAALAGAPLPSDRIIDGRDLM 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 261 PLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEGAGaCYGRKVCPCFGEKVVHHDPPLLFDLSR 340
Cdd:cd16159 401 PLLTGQEKRSPHEFLFHYCGAELHAVRYRPRDGGAVWKAHYFTPNFYPGTEG-CCGTLLCRCFGDSVTHHDPPLLFDLSA 479
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 2462629490 341 DPSETHILTPASEPvFYQVMERVQQAVWEHQRTLSPVPLQLD 382
Cdd:cd16159 480 DPSESNPLDPTDEP-YQEIIKKILEAVAEHQSSIEPVESQLS 520
|
|
| GALNS_like |
cd16026 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
46-346 |
1.51e-95 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293750 [Multi-domain] Cd Length: 399 Bit Score: 291.77 E-value: 1.51e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 46 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssigYRVLQWT 125
Cdd:cd16026 1 KPNIVVILADDLGYGDLGCYGSPLIKTPNIDRLAAEGVRFTDFYAAAPVCSPSRAALLTGRYPVRVGL-----PGVVGPP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 126 GASGGLPTNETTFAKILKEKGYATGLIG---------------------------------------------------- 153
Cdd:cd16026 76 GSKGGLPPDEITIAEVLKKAGYRTALVGkwhlghqpeflptrhgfdeyfgipysndmwpfplyrndppgplpplmeneev 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 154 ----------------------------------------------------------------------RILDTLDVEG 163
Cdd:cd16026 156 ieqpadqssltqrytdeavdfiernkdqpfflylahtmphvplfasekfkgrsgaglygdvveeldwsvgRILDALKELG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 164 LSNSTLIYFTSD---------HGGSleNQL-----GNTQYGGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGE 229
Cdd:cd16026 236 LEENTLVIFTSDngpwleyggHGGS--AGPlrggkGTTWEGG-----------------VRVPFIAWWPGVIPAGTVSDE 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 230 PTSLMDVFPTVVRLAGSEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQrdrgtmWKVHFVTPVFQPE 309
Cdd:cd16026 297 LASTMDLLPTLAALAGAPLPEDRVIDGKDISPLLLGGSKSPPHPFFYYYDGGDLQAVRSGR------WKLHLPTTYRTGT 370
|
410 420 430
....*....|....*....|....*....|....*..
gi 2462629490 310 GAGacygrkvcpcfGEKVVHHDPPLLFDLSRDPSETH 346
Cdd:cd16026 371 DPG-----------GLDPTKLEPPLLYDLEEDPGETY 396
|
|
| AslA |
COG3119 |
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism]; |
28-346 |
1.26e-81 |
|
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
Pssm-ID: 442353 [Multi-domain] Cd Length: 393 Bit Score: 255.96 E-value: 1.26e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 28 LAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRY 107
Cdd:COG3119 5 LLLLLALLAAAAAAAAAKRPNILFILADDLGYGDLGCYGNPLIKTPNIDRLAAEGVRFTNAYVTSPVCSPSRASLLTGRY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 108 PVRSGMVSSIGyrvlqwtGASGGLPTNETTFAKILKEKGYATGL------------------------------------ 151
Cdd:COG3119 85 PHRTGVTDNGE-------GYNGGLPPDEPTLAELLKEAGYRTALfgkwhlyltdlltdkaidflerqadkdkpfflylaf 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 152 -------------------------------------------------------IGRILDTLDVEGLSNSTLIYFTSDH 176
Cdd:COG3119 158 naphapyqapeeyldkydgkdiplppnlaprdlteeelrraraayaamieevddqVGRLLDALEELGLADNTIVVFTSDN 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 177 GGSLENQlG-----NTQY-GGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGSEVPQ 250
Cdd:COG3119 238 GPSLGEH-GlrggkGTLYeGG-----------------IRVPLIVRWPGKIKAGSVSDALVSLIDLLPTLLDLAGVPIPE 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 251 DrvIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRdrgtmWKVHFvtpvfqpegagaCYGRKvcpcfgekvvhh 330
Cdd:COG3119 300 D--LDGRSLLPLLTGEKAEWRDYLYWEYPRGGGNRAIRTGR-----WKLIR------------YYDDD------------ 348
|
410
....*....|....*.
gi 2462629490 331 DPPLLFDLSRDPSETH 346
Cdd:COG3119 349 GPWELYDLKNDPGETN 364
|
|
| ARS_like |
cd16142 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
47-349 |
1.70e-71 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293761 [Multi-domain] Cd Length: 372 Bit Score: 228.96 E-value: 1.70e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYG---NNTMRTPNIDRLAEDGVKLTQHISAASlCTPSRAAFLTGRYPVRSGMvssigYRVlQ 123
Cdd:cd16142 1 PNILVILGDDIGWGDLGCYGggiGRGAPTPNIDRLAKEGLRFTSFYVEPS-CTPGRAAFITGRHPIRTGL-----TTV-G 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 124 WTGASGGLPTNETTFAKILKEKGYATGL---------------------------------------------------- 151
Cdd:cd16142 74 LPGSPGGLPPWEPTLAELLKDAGYATAQfgkwhlgdedgrlptdhgfdefygnlyhtideeivdkaidfikrnakadkpf 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 152 ---------------------------------------IGRILDTLDVEGLSNSTLIYFTSDHG-----------GSLE 181
Cdd:cd16142 154 flyvnftkmhfptlpspefegkssgkgkyadsmvelddhVGQILDALDELGIADNTIVIFTTDNGpeqdvwpdggyTPFR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 182 NQLGNTQYGGWngiykggkgmggweggiRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGSEVP------QDRVID 255
Cdd:cd16142 234 GEKGTTWEGGV-----------------RVPAIVRWPGKIKPGRVSNEIVSHLDWFPTLAALAGAPDPkdkllgKDRHID 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 256 GQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQrdrgtmWKVHFVtpVFQPEGAGACYGRKVCPCfgekvvhhdpPLL 335
Cdd:cd16142 297 GVDQSPFLLGKSEKSRRSEFFYFGEGELGAVRWKN------WKVHFK--AQEDTGGPTGEPFYVLTF----------PLI 358
|
410
....*....|....
gi 2462629490 336 FDLSRDPSETHILT 349
Cdd:cd16142 359 FNLRRDPKERYDVT 372
|
|
| spARS_like |
cd16160 |
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ... |
46-363 |
2.45e-71 |
|
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293779 [Multi-domain] Cd Length: 445 Bit Score: 230.78 E-value: 2.45e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 46 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSsiGYRV-LQW 124
Cdd:cd16160 1 KPNIVLFFADDMGYGDLASYGHPTQERGPIDDMAAEGIRFTQAYSADSVCTPSRAALLTGRLPIRSGMYG--GTRVfLPW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 125 TgaSGGLPTNETTFAKILKEKGYATGLIGR-------------------------------------------------- 154
Cdd:cd16160 79 D--IGGLPKTEVTMAEALKEAGYTTGMVGKwhlginennhsdgahlpshhgfdfvgtnlpftnswacddtgrhvdfpdrs 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 --------------------------------------------------------------------------------
Cdd:cd16160 157 acflyyndtiveqpiqhehltetlvgdaksfiednqenpfflyfsfpqthtplfaskrfkgkskrgrygdninemswavg 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 155 -ILDTLDVEGLSNSTLIYFTSDHG------------GSLENQLGNTQYGGwngiykggkgmggweggIRVPGIFRWPGVL 221
Cdd:cd16160 237 eVLDTLVDTGLDQNTLVFFLSDHGphveycleggstGGLKGGKGNSWEGG-----------------IRVPFIAYWPGTI 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 222 PaGRVIGEPTSLMDVFPTVVRLAGSEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERfLHAARWHQrdrgtmWKVHF 301
Cdd:cd16160 300 K-PRVSHEVVSTMDIFPTFVDLAGGTLPTDRIYDGLSITDLLLGEADSPHDDILYYCCSR-LMAVRYGS------YKIHF 371
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462629490 302 VT---PVFQPEGAGACYGRKVCP------CFGEKVVHHDPPLLFDLSRDPSETHILTPASEPVFYQVMERV 363
Cdd:cd16160 372 KTqplPSQESLDPNCDGGGPLSDyivcydCEDECVTKHNPPLIFDVEKDPGEQYPLQPSVYEHMLEAVEKL 442
|
|
| sulfatase_like |
cd16022 |
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, ... |
47-258 |
3.32e-71 |
|
sulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293746 [Multi-domain] Cd Length: 236 Bit Score: 223.47 E-value: 3.32e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGmvssigyrVLQWTG 126
Cdd:cd16022 1 PNILLIMTDDLGYDDLGCYGNPDIKTPNLDRLAAEGVRFTNAYVASPVCSPSRASLLTGRYPHRHG--------VRGNVG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 127 ASGGLPTNETTFAKILKEKGYATGL----------------------------------------------IGRILDTLD 160
Cdd:cd16022 73 NGGGLPPDEPTLAELLKEAGYRTALigkwhdeaidfierrdkdkpfflyvsfnaphppfayyamvsaiddqIGRILDALE 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 161 VEGLSNSTLIYFTSDHGGSLENqlGNTQYGGWNgiykggkgmgGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTV 240
Cdd:cd16022 153 ELGLLDNTLIVFTSDHGDMLGD--HGLRGKKGS----------LYEGGIRVPFIVRWPGKIPAGQVSDALVSLLDLLPTL 220
|
250
....*....|....*...
gi 2462629490 241 VRLAGSEVPQDrvIDGQD 258
Cdd:cd16022 221 LDLAGIEPPEG--LDGRS 236
|
|
| Sulfatase_C |
pfam14707 |
C-terminal region of aryl-sulfatase; |
270-404 |
6.16e-60 |
|
C-terminal region of aryl-sulfatase;
Pssm-ID: 405407 [Multi-domain] Cd Length: 122 Bit Score: 190.60 E-value: 6.16e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 270 SDHEFLMHYCERFLHAARWHQrdrgtmWKVHFVTPVFQPEGAGACYGRKVCpcfgekVVHHDPPLLFDLSRDPSETHILT 349
Cdd:pfam14707 1 SPHEFLFHYCGAALHAVRWGP------YKAHFFTPSFDPPGAEGCYGSKVP------VTHHDPPLLFDLERDPSEKYPLS 68
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 2462629490 350 PASePVFYQVMERVQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCCGPFPLCWC 404
Cdd:pfam14707 69 PDS-PEYPEVLAEIKAAVEEHKATLVPVPNQLSKGNYLWDPWLQPCCPTFPACTC 122
|
|
| ARS_like |
cd16144 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
47-346 |
1.15e-59 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293763 [Multi-domain] Cd Length: 421 Bit Score: 199.69 E-value: 1.15e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTG 126
Cdd:cd16144 1 PNIVLILVDDLGWADLGCYGSKFYETPNIDRLAKEGMRFTQAYAAAPVCSPSRASILTGQYPARLGITDVIPGRRGPPDN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 127 A-------SGGLPTNETTFAKILKEKGYATGLIG---------------------------------------------- 153
Cdd:cd16144 81 TklipppsTTRLPLEEVTIAEALKDAGYATAHFGkwhlggeggygpedqgfdvniggtgnggppsyyfppgkpnpdledg 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 154 -----------------------------------------------------------------------------RIL 156
Cdd:cd16144 161 pegeyltdrltdeaidfieqnkdkpfflylshyavhtpiqarpeliekyekkkkglrkgqknpvyaamiesldesvgRIL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 157 DTLDVEGLSNSTLIYFTSDHGG-SLENQLGNTQY-----------GGwngiykggkgmggweggIRVPGIFRWPGVLPAG 224
Cdd:cd16144 241 DALEELGLADNTLVIFTSDNGGlSTRGGPPTSNAplrggkgslyeGG-----------------IRVPLIVRWPGVIKPG 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 225 RVIGEPTSLMDVFPTVVRLAGSEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYcerFLHAARWHQRDRGTM----WK-V 299
Cdd:cd16144 304 SVSDVPVIGTDLYPTFLELAGGPLPPPQHLDGVSLVPLLKGGEADLPRRALFWH---FPHYHGQGGRPASAIrkgdWKlI 380
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 2462629490 300 HFvtpvfqpegagacygrkvcpcfgekvvHHDPPL-LFDLSRDPSETH 346
Cdd:cd16144 381 EF---------------------------YEDGRVeLYNLKNDIGETN 401
|
|
| ARSG |
cd16161 |
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ... |
46-349 |
2.08e-59 |
|
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.
Pssm-ID: 293780 [Multi-domain] Cd Length: 383 Bit Score: 198.08 E-value: 2.08e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 46 RPNILLLMADDLGIGDIGCYGN-NTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRvlqw 124
Cdd:cd16161 1 KPNFLLLFADDLGWGDLGANWApNAILTPNLDKLAAEGTRFVDWYSAASVCSPSRASLMTGRLGLRNGVGHNFLPT---- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 125 tgASGGLPTNETTFAKILKEKGYATG------------------------------------------------------ 150
Cdd:cd16161 77 --SVGGLPLNETTLAEVLRQAGYATGmigkwhlgqreaylpnsrgfdyyfgipfshdssladryaqfatdfiqrasakdr 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 151 ----------------------------------------LIGRILDTLDVEGLSNSTLIYFTSDHG-----GSLENQLG 185
Cdd:cd16161 155 pfflyaalahvhvplanlprfqsptsgrgpygdalqemddLVGQIMDAVKHAGLKDNTLTWFTSDNGpwevkCELAVGPG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 186 NTQY---GGWNGIYKGGKGMGgweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGSEVPQDRVIDGQDLLPL 262
Cdd:cd16161 235 TGDWqgnLGGSVAKASTWEGG-----HREPAIVYWPGRIPANSTSAALVSTLDIFPTVVALAGASLPPGRIYDGKDLSPV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 263 LLGTAQhSDHEFLMHYCE-----RFLHAARWHQrdrgtmWKVHFVTpvfqpEGAGACygrkvCPCFGEKvVHHDPPLLFD 337
Cdd:cd16161 310 LFGGSK-TGHRCLFHPNSgaagaGALSAVRCGD------YKAHYAT-----GGALAC-----CGSTGPK-LYHDPPLLFD 371
|
410
....*....|..
gi 2462629490 338 LSRDPSETHILT 349
Cdd:cd16161 372 LEVDPAESFPLT 383
|
|
| ARSA |
cd16158 |
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ... |
47-404 |
1.18e-57 |
|
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.
Pssm-ID: 293777 [Multi-domain] Cd Length: 479 Bit Score: 196.13 E-value: 1.18e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYrvlqwTG 126
Cdd:cd16158 2 PNIVLLFADDLGYGDLGCYGHPSSSTPNLDRLAANGLRFTDFYSSSPVCSPSRAALLTGRYQVRSGVYPGVFY-----PG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 127 ASGGLPTNETTFAKILKEKGYATGLIGR---------------------------------------------------- 154
Cdd:cd16158 77 SRGGLPLNETTIAEVLKTVGYQTAMVGKwhlgvglngtylpthqgfdhylgipyshdqgpcqnltcfppnipcfggcdqg 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 --------------------------------------------------------------------------------
Cdd:cd16158 157 evpcplfynesivqqpvdlltleeryakfakdfiadnakegkpfflyyashhthypqfagqkfagrssrgpfgdalaeld 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 155 -----ILDTLDVEGLSNSTLIYFTSDHG------------GSLENQLGNTQYGGwngiykggkgmggweggIRVPGIFRW 217
Cdd:cd16158 237 gsvgeLLQTLKENGIDNNTLVFFTSDNGpstmrksrggnaGLLKCGKGTTYEGG-----------------VREPAIAYW 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 218 PGVLPAGRVIgEPTSLMDVFPTVVRLAGSEVPqDRVIDGQDLLPLLLGTAQHSDHEFLMHYC----ERFLHAARWHQrdr 293
Cdd:cd16158 300 PGRIKPGVTH-ELASTLDILPTIAKLAGAPLP-NVTLDGVDMSPILFEQGKSPRQTFFYYPTspdpDKGVFAVRWGK--- 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 294 gtmWKVHFVT---PVFQPEGAGACYGRKvcpcfgeKVVHHDPPLLFDLSRDPSETHILTpaSEPVFYQVMERVQQAVWEH 370
Cdd:cd16158 375 ---YKAHFYTqgaAHSGTTPDKDCHPSA-------ELTSHDPPLLFDLSQDPSENYNLL--GLPEYNQVLKQIQQVKERF 442
|
490 500 510
....*....|....*....|....*....|....*...
gi 2462629490 371 QRTLSPVPLQLDRLGNiwrPWLQPC----CGPFPLCWC 404
Cdd:cd16158 443 EASMKFGESEINKGED---PALEPCckpgCTPKPSCCQ 477
|
|
| ARS_like |
cd16143 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
47-346 |
7.10e-54 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293762 [Multi-domain] Cd Length: 395 Bit Score: 183.56 E-value: 7.10e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYG-NNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssiGYRVLQWT 125
Cdd:cd16143 1 PNIVIILADDLGYGDISCYNpDSKIPTPNIDRLAAEGMRFTDAHSPSSVCTPSRYGLLTGRYPWRSRL----KGGVLGGF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 126 GASGgLPTNETTFAKILKEKGYATGLIG---------------------------------------------------- 153
Cdd:cd16143 77 SPPL-IEPDRVTLAKMLKQAGYRTAMVGkwhlgldwkkkdgkkaatgtgkdvdyskpikggpldhgfdyyfgipasevlp 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 154 ------------------------------------------------------------RILDTLDVEGLSNSTLIYFT 173
Cdd:cd16143 156 tltdkavefidqhakkdkpfflyfalpaphtpivpspefqgksgagpygdfvyeldwvvgRILDALKELGLAENTLVIFT 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 174 SDHGGSLENQLGNTQ-----------------Y-GGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMD 235
Cdd:cd16143 236 SDNGPSPYADYKELEkfghdpsgplrgmkadiYeGG-----------------HRVPFIVRWPGKIPAGSVSDQLVSLTD 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 236 VFPTVVRLAGSEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHycerflHAARWHQRDRGTMWKVhfvtpVFQPEGAGACY 315
Cdd:cd16143 299 LFATLAAIVGQKLPDNAAEDSFSFLPALLGPKKQEVRESLVH------HSGNGSFAIRKGDWKL-----IDGTGSGGFSY 367
|
410 420 430
....*....|....*....|....*....|..
gi 2462629490 316 GRKvcpcfgeKVVHHDPP-LLFDLSRDPSETH 346
Cdd:cd16143 368 PRG-------KEKLGLPPgQLYNLSTDPGESN 392
|
|
| GALNS |
cd16157 |
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ... |
46-382 |
5.67e-50 |
|
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.
Pssm-ID: 293776 [Multi-domain] Cd Length: 466 Bit Score: 175.35 E-value: 5.67e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 46 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWT 125
Cdd:cd16157 1 KPNIILMLMDDMGWGDLGVFGEPSRETPNLDRMAAEGMLFTDFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 126 GAS--GGLPTNETTFAKILKEKGYATGLIGR------------------------------------------------- 154
Cdd:cd16157 81 PQNivGGIPDSEILLPELLKKAGYRNKIVGKwhlghrpqyhplkhgfdewfgapnchfgpydnkaypnipvyrdwemigr 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 155 -------------------------------------------------------------------------------I 155
Cdd:cd16157 161 yyeefkidkktgesnltqiylqealefiekqhdaqkpfflywapdathapvyaskpflgtsqrglygdavmeldssvgkI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 156 LDTLDVEGLSNSTLIYFTSDHGGSLenqLGNTQYGGWNGIYKGGKGMGGWEGgIRVPGIFRWPGVLPAGRVIGEPTSLMD 235
Cdd:cd16157 241 LESLKSLGIENNTFVFFSSDNGAAL---ISAPEQGGSNGPFLCGKQTTFEGG-MREPAIAWWPGHIKPGQVSHQLGSLMD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 236 VFPTVVRLAGSEVPQDRVIDGQDLLPLLLgtAQHSDHEFLMHYCERFLHAARWHQrdrgtmWKVHFVT----PVFQPEGA 311
Cdd:cd16157 317 LFTTSLALAGLPIPSDRAIDGIDLLPVLL--NGKEKDRPIFYYRGDELMAVRLGQ------YKAHFWTwsnsWEEFRKGI 388
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462629490 312 GACYGRKVCPCFGEKVVHH-DPPLLFDLSRDPSETHILTPASePVFYQVMERVQQAVWEHQRTLSPVPLQLD 382
Cdd:cd16157 389 NFCPGQNVPGVTTHNQTDHtKLPLLFHLGRDPGEKYPISFKS-AEYKQAMPRISKVVQQHQKTLVPGEPQLN 459
|
|
| SGSH |
cd16027 |
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ... |
47-372 |
2.50e-49 |
|
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.
Pssm-ID: 293751 [Multi-domain] Cd Length: 373 Bit Score: 171.15 E-value: 2.50e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIgDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssIGYRVLQWTg 126
Cdd:cd16027 1 PNILWIIADDLSP-DLGGYGGNVVKTPNLDRLAAEGVRFTNAFTTAPVCSPSRSALLTGLYPHQNGA---HGLRSRGFP- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 127 asggLPTNETTFAKILKEKGYATGL------------------------------------------------------- 151
Cdd:cd16027 76 ----LPDGVKTLPELLREAGYYTGLigkthynpdavfpfddemrgpddggrnawdyasnaadflnrakkgqpfflwfgfh 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 152 --------------------------------------------------IGRILDTLDVEGLSNSTLIYFTSDHGGSLE 181
Cdd:cd16027 152 dphrpyppgdgeepgydpekvkvppylpdtpevredladyydeierldqqVGEILDELEEDGLLDNTIVIFTSDHGMPFP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 182 NQLGNTQYGGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGSEVPQDrvIDGQDLLP 261
Cdd:cd16027 232 RAKGTLYDSG-----------------LRVPLIVRWPGKIKPGSVSDALVSFIDLAPTLLDLAGIEPPEY--LQGRSFLP 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 262 LLLG-TAQHSDHEFLMH-------YCERFLHAARWHqrdrgtmwkvhfvtpvfqpegagacYgrkvcpcfgekVVHHDPP 333
Cdd:cd16027 293 LLKGeKDPGRDYVFAERdrhdetyDPIRSVRTGRYK-------------------------Y-----------IRNYMPE 336
|
410 420 430
....*....|....*....|....*....|....*....
gi 2462629490 334 LLFDLSRDPSETHILtpASEPVFYQVMERVQQAVWEHQR 372
Cdd:cd16027 337 ELYDLKNDPDELNNL--ADDPEYAEVLEELRAALDAWMK 373
|
|
| ARS_like |
cd16146 |
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide ... |
47-369 |
6.67e-49 |
|
uncharacterized arylsulfatase; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293765 [Multi-domain] Cd Length: 409 Bit Score: 170.81 E-value: 6.67e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQ-HISaaSLCTPSRAAFLTGRYPVRSGMVSSIGYRVLqwt 125
Cdd:cd16146 1 PNVILILTDDQGYGDLGFHGNPILKTPNLDRLAAESVRFTNfHVS--PVCAPTRAALLTGRYPFRTGVWHTILGRER--- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 126 gasggLPTNETTFAKILKEKGYATGL------------------------------------------------------ 151
Cdd:cd16146 76 -----MRLDETTLAEVFKDAGYRTGIfgkwhlgdnypyrpqdrgfdevlghggggigqypdywgndyfddtyyhngkfvk 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 152 ----------------------------------------------------------------------IGRILDTLDV 161
Cdd:cd16146 151 tegyctdvffdeaidfieenkdkpffaylatnaphgplqvpdkyldpykdmglddklaafygmieniddnVGRLLAKLKE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 162 EGLSNSTLIYFTSDHGGSLENQLGN---------TQY-GGwngiykggkgmggweggIRVPGIFRWPGVLPAGRVIGEPT 231
Cdd:cd16146 231 LGLEENTIVIFMSDNGPAGGVPKRFnagmrgkkgSVYeGG-----------------HRVPFFIRWPGKILAGKDVDTLT 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 232 SLMDVFPTVVRLAGSEVPQDRVIDGQDLLPLLLGTAQHSDHEFLmhycerFLHaarWHQRDRGTMWKVHFVtpVFQPEga 311
Cdd:cd16146 294 AHIDLLPTLLDLCGVKLPEGIKLDGRSLLPLLKGESDPWPERTL------FTH---SGRWPPPPKKKRNAA--VRTGR-- 360
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 2462629490 312 gacYgRKVCPcfgekvvHHDPPLLFDLSRDPSETHILTpASEPVFYQVMERVQQAVWE 369
Cdd:cd16146 361 ---W-RLVSP-------KGFQPELYDIENDPGEENDVA-DEHPEVVKRLKAAYEAWWD 406
|
|
| ARS_like |
cd16145 |
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ... |
47-346 |
1.20e-48 |
|
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293764 [Multi-domain] Cd Length: 415 Bit Score: 170.47 E-value: 1.20e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssigyRVLQWTG 126
Cdd:cd16145 1 PNIIFILADDLGYGDLGCYGQKKIKTPNLDRLAAEGMRFTQHYAGAPVCAPSRASLLTGLHTGHTRV------RGNSEPG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 127 ASGGLPTNETTFAKILKEKGYATGLIG----------------------------------------------------- 153
Cdd:cd16145 75 GQDPLPPDDVTLAEVLKKAGYATAAFGkwglggpgtpghptkqgfdyfygyldqvhahnyypeylwrngekvplpnnvip 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 --------------------------------------------------------------------------------
Cdd:cd16145 155 pldegnnagggggtyshdlftdealdfirenkdkpfflylaytlphaplqvpddgpykykpkdpgiyaylpwpqpekaya 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 154 -----------RILDTLDVEGLSNSTLIYFTSDHGGSLEnqlGNTQY--------------------GGwngiykggkgm 202
Cdd:cd16145 235 amvtrldrdvgRILALLKELGIDENTLVVFTSDNGPHSE---GGSEHdpdffdsngplrgykrslyeGG----------- 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 203 ggweggIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGSEVPQDrvIDGQDLLPLLLGTAQHSDHEFLmhYCERF 282
Cdd:cd16145 301 ------IRVPFIARWPGKIPAGSVSDHPSAFWDFMPTLADLAGAEPPED--IDGISLLPTLLGKPQQQQHDYL--YWEFY 370
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462629490 283 LH----AARWHQrdrgtmWKVhfvtpVFQPEGAGacygrkvcpcfgekvvhhdPPLLFDLSRDPSETH 346
Cdd:cd16145 371 EGggaqAVRMGG------WKA-----VRHGKKDG-------------------PFELYDLSTDPGETN 408
|
|
| PAS_like |
cd16025 |
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze ... |
46-346 |
7.36e-45 |
|
Bacterial Arylsulfatase of Pseudomonas aeruginosa and related proteins; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293749 [Multi-domain] Cd Length: 402 Bit Score: 159.92 E-value: 7.36e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 46 RPNILLLMADDLGIGDIGCYGNNtMRTPNIDRLAEDGVKLTQ-HisAASLCTPSRAAFLTGRYPVRSGMvSSIGYRVLQW 124
Cdd:cd16025 2 RPNILLILADDLGFSDLGCFGGE-IPTPNLDALAAEGLRFTNfH--TTALCSPTRAALLTGRNHHQVGM-GTMAELATGK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 125 TGASGGLPTNETTFAKILKEKGYAT------------------------------------------------------- 149
Cdd:cd16025 78 PGYEGYLPDSAATIAEVLKDAGYHTymsgkwhlgpddyystddltdkaieyideqkapdkpfflylafgaphaplqapke 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 150 ---------------------------GL---------------------------------------------IGRILD 157
Cdd:cd16025 158 widkykgkydagwdalreerlerqkelGLipadtkltprppgvpawdslspeekklearrmevyaamvehmdqqIGRLID 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 158 TLDVEGLSNSTLIYFTSDHGGSLEN---QLGNTQY---------GGwngiykggkgmggweggIRVPGIFRWP-GVLPAG 224
Cdd:cd16025 238 YLKELGELDNTLIIFLSDNGASAEPgwaNASNTPFrlykqasheGG-----------------IRTPLIVSWPkGIKAKG 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 225 RVIGEPTSLMDVFPTVVRLAGSEVPQDRV------IDGQDLLPLLLGTAQHSDHEFLmhYCERFLHAARWHQRdrgtmWK 298
Cdd:cd16025 301 GIRHQFAHVIDIAPTILELAGVEYPKTVNgvpqlpLDGVSLLPTLDGAAAPSRRRTQ--YFELFGNRAIRKGG-----WK 373
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 2462629490 299 VhfvtpvfqpegagacygrkvcpcfgekVVHHDPPL------LFDLSRDPSETH 346
Cdd:cd16025 374 A---------------------------VALHPPPGwgdqweLYDLAKDPSETH 400
|
|
| sulfatase_like |
cd16149 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
47-261 |
1.25e-42 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293768 [Multi-domain] Cd Length: 257 Bit Score: 150.08 E-value: 1.25e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTG 126
Cdd:cd16149 1 PNILFILTDDQGPWALGCYGNSEAVTPNLDRLAAEGVRFENFFCTSPVCSPARASLLTGRMPSQHGIHDWIVEGSHGKTK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 127 ASGGLPTNETTFAKILKEKGYATGL-------------------------------------------------IGRILD 157
Cdd:cd16149 81 KPEGYLEGQTTLPEVLQDAGYRCGLsgkwhlgddaadflrrraeaekpfflsvnytaphspwgyfaavtgvdrnVGRLLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 158 TLDVEGLSNSTLIYFTSDHGGSLenqlgnTQYGGW---------NgiykggkgmgGWEGGIRVPGIFRWPGVLPAGRVIG 228
Cdd:cd16149 161 ELEELGLTENTLVIFTSDNGFNM------GHHGIWgkgngtfplN----------MYDNSVKVPFIIRWPGVVPAGRVVD 224
|
250 260 270
....*....|....*....|....*....|...
gi 2462629490 229 EPTSLMDVFPTVVRLAGSEVPQDRVIDGQDLLP 261
Cdd:cd16149 225 SLVSAYDFFPTLLELAGVDPPADPRLPGRSFAD 257
|
|
| sulfatase_like |
cd16151 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
47-288 |
5.72e-42 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293770 [Multi-domain] Cd Length: 377 Bit Score: 151.60 E-value: 5.72e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTqHISAASLCTPSRAAFLTGRYPVRSGMVssigyrvlqwtg 126
Cdd:cd16151 1 PNIILIMADDLGYECIGCYGGESYKTPNIDALAAEGVRFN-NAYAQPLCTPSRVQLMTGKYNFRNYVV------------ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 127 aSGGLPTNETTFAKILKEKGYATG-------------------------------------------------------- 150
Cdd:cd16151 68 -FGYLDPKQKTFGHLLKDAGYATAiagkwqlgggrgdgdyphefgfdeyclwqltetgekysrpatptfnirngkllett 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 151 ----------------------------------------------------------------------LIGRILDTLD 160
Cdd:cd16151 147 egdygpdlfadflidfiernkdqpffayypmvlvhdpfvptpdspdwdpddkrkkddpeyfpdmvaymdkLVGKLVDKLE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 161 VEGLSNSTLIYFTSDHG--GSLENQLGNTQY-GGwngiykggkGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVF 237
Cdd:cd16151 227 ELGLRENTIIIFTGDNGthRPITSRTNGREVrGG---------KGKTTDAGTHVPLIVNWPGLIPAGGVSDDLVDFSDFL 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 2462629490 238 PTVVRLAGSEVPQDRVIDGQDLLPLLLG-TAQHSDHEFLMHY-------CERFLHAARW 288
Cdd:cd16151 298 PTLAELAGAPLPEDYPLDGRSFAPQLLGkTGSPRREWIYWYYrnphkkfGSRFVRTKRY 356
|
|
| sulfatase_like |
cd16037 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
47-342 |
4.76e-40 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293760 [Multi-domain] Cd Length: 321 Bit Score: 144.99 E-value: 4.76e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRsgmvssIGYrvlqWTG 126
Cdd:cd16037 1 PNILIIMSDEHNPDAMGCYGHPVVRTPNLDRLAARGTRFENAYTPSPICVPSRASFLTGRYVHE------TGV----WDN 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 127 ASgGLPTNETTFAKILKEKGYAT--------------------------------------------------------- 149
Cdd:cd16037 71 AD-PYDGDVPSWGHALRAAGYETvligklhfrgedqrhgfrydrdvteaavdwlreeaaddkpwflfvgfvaphfpliap 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 150 ----------------GL-------IGRILDTLDVEGLSNSTLIYFTSDHGgsleNQLG-------NTQYggwngiykgg 199
Cdd:cd16037 150 qefydlyvrraraayyGLvefldenIGRVLDALEELGLLDNTLIIYTSDHG----DMLGerglwgkSTMY---------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 200 kgmggwEGGIRVPGIFRWPGVlPAGRVIGEPTSLMDVFPTVVRLAGseVPQDRVIDGQDLLPLLLGTAQHSDHEFlmhyC 279
Cdd:cd16037 216 ------EESVRVPMIISGPGI-PAGKRVKTPVSLVDLAPTILEAAG--APPPPDLDGRSLLPLAEGPDDPDRVVF----S 282
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462629490 280 ErfLHAARwhQRDRGTM-----WK-VHFVtpvfqpegagacygrkvcpcfgekvvhHDPPLLFDLSRDP 342
Cdd:cd16037 283 E--YHAHG--SPSGAFMlrkgrWKyIYYV---------------------------GYPPQLFDLENDP 320
|
|
| sulfatase_like |
cd16034 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-348 |
2.85e-38 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293758 [Multi-domain] Cd Length: 399 Bit Score: 142.32 E-value: 2.85e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 46 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVsSIGYRvlqwt 125
Cdd:cd16034 1 KPNILFIFADQHRAQALGCAGDDPVKTPNLDRLAKEGVVFTNAVSNYPVCSPYRASLLTGQYPLTNGVF-GNDVP----- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 126 gasggLPTNETTFAKILKEKGYATGLIG---------------------------------------------------- 153
Cdd:cd16034 75 -----LPPDAPTIADVLKDAGYRTGYIGkwhldgperndgraddytppperrhgfdywkgyecnhdhnnphyydddgkri 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 --------------------------------------------------------------------------------
Cdd:cd16034 150 yikgyspdaetdlaieylenqadkdkpfalvlswnpphdpyttapeeyldmydpkklllrpnvpedkkeeaglredlrgy 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 154 ------------RILDTLDVEGLSNSTLIYFTSDHG---GSLENQLGNTQYGGwngiykggkgmggwegGIRVPGIFRWP 218
Cdd:cd16034 230 yamitalddnigRLLDALKELGLLENTIVVFTSDHGdmlGSHGLMNKQVPYEE----------------SIRVPFIIRYP 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 219 GVLPAGRVIGEPTSLMDVFPTVVRLAGSEVPQDrvIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTM-- 296
Cdd:cd16034 294 GKIKAGRVVDLLINTVDIMPTLLGLCGLPIPDT--VEGRDLSPLLLGGKDDEPDSVLLQCFVPFGGGSARDGGEWRGVrt 371
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....
gi 2462629490 297 --WKvhFVtpvfqpegagacygrkvcpcfgekVVHHDPPLLFDLSRDPSETHIL 348
Cdd:cd16034 372 drYT--YV------------------------RDKNGPWLLFDNEKDPYQLNNL 399
|
|
| choline-sulfatase |
cd16032 |
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from ... |
47-342 |
2.88e-38 |
|
choline-sulfatase; Choline-sulphatase is involved in the synthesis of glycine betaine from choline. The symbiotic soil bacterium Rhizobium meliloti can synthesize glycine betaine from choline-O-sulphate and choline to protect itself from osmotic stress. This biosynthetic pathway is encoded by the betICBA locus, which comprises a regulatory gene, betI, and three structural genes, betC (choline sulfatase), betB (betaine aldehyde dehydrogenase), and betA (choline dehydrogenase). betICBA genes constitute a single operon.
Pssm-ID: 293756 [Multi-domain] Cd Length: 327 Bit Score: 140.41 E-value: 2.88e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssigyrvlqWTG 126
Cdd:cd16032 1 PNILLIMADQLTAAALPAYGNTVVKTPNLDRLAARGVVFDNAYCNSPLCAPSRASMMTGRLPSRIGA----------YDN 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 127 ASGgLPTNETTFAKILKEKGYATGL------------------------------------------------------- 151
Cdd:cd16032 71 AAE-FPADIPTFAHYLRAAGYRTALsgkmhfvgpdqlhgfdydeevafkavqklydlargedgrpffltvsfthphdpyv 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 152 ---------------------------IGRILDTLDVEGLSNSTLIYFTSDHGgsleNQLGntQYGGWngiykggKGMGG 204
Cdd:cd16032 150 ipqeywdlyvrrarrayygmvsyvddkVGQLLDTLERTGLADDTIVIFTSDHG----DMLG--ERGLW-------YKMSF 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 205 WEGGIRVPGIFRWPGvLPAGRVIGEPTSLMDVFPTVVRLAGSEVPQDRV-IDGQDLLPLLLGTAQHSDHEFLMHYCErfl 283
Cdd:cd16032 217 FEGSARVPLIISAPG-RFAPRRVAEPVSLVDLLPTLVDLAGGGTAPHVPpLDGRSLLPLLEGGDSGGEDEVISEYLA--- 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462629490 284 haarwhqrdrgtmwkvhfvtpvfqpEGAGAcygrkvcPCF-----GEKVVH--HDPPLLFDLSRDP 342
Cdd:cd16032 293 -------------------------EGAVA-------PCVmirrgRWKFIYcpGDPDQLFDLEADP 326
|
|
| G6S_like |
cd16031 |
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); ... |
45-365 |
6.45e-38 |
|
unchracterized sulfatase homologous to glucosamine (N-acetyl)-6-sulfatase(G6S, GNS); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficiency of N-acetylglucosamine-6-sulfatase results in the disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease.
Pssm-ID: 293755 [Multi-domain] Cd Length: 429 Bit Score: 141.90 E-value: 6.45e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 45 SRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVssigyrvlqw 124
Cdd:cd16031 1 KRPNIIFILTDDHRYDALGCYGNPIVKTPNIDRLAKEGVRFDNAFVTTSICAPSRASILTGQYSHRHGVT---------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 125 TGASGGLPTNETTFAKILKEKGYATGLIG--------------------------------------------------- 153
Cdd:cd16031 71 DNNGPLFDASQPTYPKLLRKAGYQTAFIGkwhlgsggdlpppgfdywvsfpgqgsyydpefiengkrvgqkgyvtdiitd 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 --------------------------------------------------------------------------------
Cdd:cd16031 151 kaldflkerdkdkpfclslsfkaphrpftpaprhrglyedvtipepetfddddyagrpewareqrnrirgvldgrfdtpe 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 154 ---------------------RILDTLDVEGLSNSTLIYFTSDHGgsleNQLGNTQYGG-WNgiykggkgmgGWEGGIRV 211
Cdd:cd16031 231 kyqrymkdylrtvtgvddnvgRILDYLEEQGLADNTIIIYTSDNG----FFLGEHGLFDkRL----------MYEESIRV 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 212 PGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGSEVPQDrvIDGQDLLPLLLGTAQHS-DHEFLMHYCE--RFLHAARW 288
Cdd:cd16031 297 PLIIRDPRLIKAGTVVDALVLNIDFAPTILDLAGVPIPED--MQGRSLLPLLEGEKPVDwRKEFYYEYYEepNFHNVPTH 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 289 H--QRDRgtmWK-VHFvtpvfqpegagacygrkvcpcfgekvvHHDPPL--LFDLSRDPSETH--ILTPASEPVFYQVME 361
Cdd:cd16031 375 EgvRTER---YKyIYY---------------------------YGVWDEeeLYDLKKDPLELNnlANDPEYAEVLKELRK 424
|
....
gi 2462629490 362 RVQQ 365
Cdd:cd16031 425 RLEE 428
|
|
| sulfatase_like |
cd16148 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
47-261 |
1.10e-36 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293767 [Multi-domain] Cd Length: 271 Bit Score: 134.60 E-value: 1.10e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLgIGD-IGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPvrsgmvssigyrvLQWT 125
Cdd:cd16148 1 MNVILIVIDSL-RADhLGCYGYDRVTTPNLDRLAAEGVVFDNHYSGSNPTLPSRFSLFTGLYP-------------FYHG 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 126 GASGGLPTNETTFAKILKEKGYATGL------------------------------------------------------ 151
Cdd:cd16148 67 VWGGPLEPDDPTLAEILRKAGYYTAAvssnphlfggpgfdrgfdtfedfrgqegdpgeegderaervtdralewldrnad 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 152 -----------------------------IGRILDTLDVEGLSNSTLIYFTSDHGGSLeNQLGNTQYGGWNgiykggkgm 202
Cdd:cd16148 147 ddpfflflhyfdphepylydaevryvdeqIGRLLDKLKELGLLEDTLVIVTSDHGEEF-GEHGLYWGHGSN--------- 216
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 2462629490 203 gGWEGGIRVPGIFRWPGVLPAGRvIGEPTSLMDVFPTVVRLAGSEVPQDrvIDGQDLLP 261
Cdd:cd16148 217 -LYDEQLHVPLIIRWPGKEPGKR-VDALVSHIDIAPTLLDLLGVEPPDY--SDGRSLLP 271
|
|
| 4-S |
cd16029 |
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the ... |
47-346 |
3.81e-36 |
|
N-acetylgalactosamine 4-sulfatase, also called arylsulftase B; Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of substrates. N-acetylgalactosamine 4-sulfatase catalyzes the removal of the sulfate ester group from position 4 of an N-acetylgalactosamine sugar at the non-reducing terminus of the polysaccharide in the degradative pathways of the glycosaminoglycans dermatan sulfate and chondroitin-4-sulfate. N-acetylgalactosamine 4-sulfatase is a lysosomal enzyme.
Pssm-ID: 293753 [Multi-domain] Cd Length: 393 Bit Score: 136.53 E-value: 3.81e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASlCTPSRAAFLTGRYPVRSGMvssiGYRVLqWTG 126
Cdd:cd16029 1 PHIVFILADDLGWNDVGFHGSDQIKTPNLDALAADGVILNNYYVQPI-CTPSRAALMTGRYPIHTGM----QHGVI-LAG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 127 ASGGLPTNETTFAKILKEKGYATGLIG----------------------------------------------------- 153
Cdd:cd16029 75 EPYGLPLNETLLPQYLKELGYATHLVGkwhlgfytweytptnrgfdsfygyyggaedyythtsggandygnddlrdneep 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 --------------------------------------------------------------------------------
Cdd:cd16029 155 awdyngtystdlftdravdiienhdpskplflylafqavhaplqvppeyadpyedkfahikdedrrtyaamvsaldesvg 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 154 RILDTLDVEGLSNSTLIYFTSDHGGSLENQLG----------NTQY-GGwngiykggkgmggweggIRVPGiFRWPGVLP 222
Cdd:cd16029 235 NVVDALKAKGMLDNTLIVFTSDNGGPTGGGDGgsnyplrggkNTLWeGG-----------------VRVPA-FVWSPLLP 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 223 --AGRVIGEPTSLMDVFPTVVRLAGSEVPQDRVIDGQDLLPLLLGTAQHSDHEFLmhycerflhaarwHQRDRgtmwkvh 300
Cdd:cd16029 297 pkRGTVSDGLMHVTDWLPTLLSLAGGDPDDLPPLDGVDQWDALSGGAPSPRTEIL-------------LNIDD------- 356
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 2462629490 301 fvtPVFQPEGAGACYGRKvcpcfgeKVVHHDPplLFDLSRDPSETH 346
Cdd:cd16029 357 ---ITRTTGGAAIRVGDW-------KLIVGKP--LFNIENDPCERN 390
|
|
| sulfatase_like |
cd16033 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
47-369 |
3.09e-34 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293757 [Multi-domain] Cd Length: 411 Bit Score: 131.57 E-value: 3.09e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGyrvlqWTG 126
Cdd:cd16033 1 PNILFIMTDQQRYDTLGCYGNPIVKTPNIDRLAAEGVRFTNAYTPSPVCCPARASLLTGLYPHEHGVLNNVE-----NAG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 127 A-SGGLPTNETTFAKILKEKGYATG------------------------------------------------------- 150
Cdd:cd16033 76 AySRGLPPGVETFSEDLREAGYRNGyvgkwhvgpeetpldygfdeylpvettieyfladraiemleelaaddkpfflrvn 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 151 -------------------------------------------------------------------------LIGRILD 157
Cdd:cd16033 156 fwgphdpyippepyldmydpediplpesfaddfedkpyiyrrerkrwgvdtedeedwkeiiahywgyitliddAIGRILD 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 158 TLDVEGLSNSTLIYFTSDHGGSLENQlgntqyGGWNGIYKGGKGMGgweggiRVPGIFRWPGVLPAGRVIGEPTSLMDVF 237
Cdd:cd16033 236 ALEELGLADDTLVIFTSDHGDALGAH------RLWDKGPFMYEETY------RIPLIIKWPGVIAAGQVVDEFVSLLDLA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 238 PTVVRLAGSEVPQDrvIDGQDLLPLLLGT----------AQHSDHEFLmhYCERFLHAARWHQrdrgtmwkvhfvtpVFQ 307
Cdd:cd16033 304 PTILDLAGVDVPPK--VDGRSLLPLLRGEqpedwrdevvTEYNGHEFY--LPQRMVRTDRYKY--------------VFN 365
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462629490 308 PEGagacygrkvcpcFGEkvvhhdpplLFDLSRDPSETHILtpASEPVFYQVMERVQQAVWE 369
Cdd:cd16033 366 GFD------------IDE---------LYDLESDPYELNNL--IDDPEYEEILREMRTRLYE 404
|
|
| ALP_like |
cd00016 |
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ... |
47-244 |
4.09e-33 |
|
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.
Pssm-ID: 293732 [Multi-domain] Cd Length: 237 Bit Score: 124.46 E-value: 4.09e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKL-TQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQwT 125
Cdd:cd00016 1 KHVVLIVLDGLGADDLGKAGNPAPTTPNLKRLASEGATFnFRSVSPPTSSAPNHAALLTGAYPTLHGYTGNGSADPEL-P 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 126 GASGGLPTNETTFAKILKEKGYATGL-------------------------------------------------IGRIL 156
Cdd:cd00016 80 SRAAGKDEDGPTIPELLKQAGYRTGVigllkaidetskekpfvlflhfdgpdgpghaygpntpeyydaveeiderIGKVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 157 DTLDVEGLSNSTLIYFTSDHGGSLENqLGNTqyggwngiYKGGKGMGGWEGGIRVPGIFRWPGVlPAGRVIGEPTSLMDV 236
Cdd:cd00016 160 DALKKAGDADDTVIIVTADHGGIDKG-HGGD--------PKADGKADKSHTGMRVPFIAYGPGV-KKGGVKHELISQYDI 229
|
....*...
gi 2462629490 237 FPTVVRLA 244
Cdd:cd00016 230 APTLADLL 237
|
|
| Sulfatase |
pfam00884 |
Sulfatase; |
47-246 |
4.89e-33 |
|
Sulfatase;
Pssm-ID: 459979 [Multi-domain] Cd Length: 298 Bit Score: 125.61 E-value: 4.89e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGyrvlqwtg 126
Cdd:pfam00884 1 PNVVLVLGESLRAPDLGLYGYPRPTTPFLDRLAEEGLLFSNFYSGGTLTAPSRFALLTGLPPHNFGSYVSTP-------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 127 asGGLPTNETTFAKILKEKGYATG-------------------------------------------------------- 150
Cdd:pfam00884 73 --VGLPRTEPSLPDLLKRAGYNTGaigkwhlgwynnqspcnlgfdkffgrntgsdlyadppdvpyncsgggvsdeallde 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 151 -------------------------------------------------------------LIGRILDTLDVEGLSNSTL 169
Cdd:pfam00884 151 alefldnndkpfflvlhtlgshgppyypdrypekyatfkpsscseeqllnsydntllytddAIGRVLDKLEENGLLDNTL 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462629490 170 IYFTSDHGGSLENQLGNTQYGGWNgiykggkgmGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGS 246
Cdd:pfam00884 231 VVYTSDHGESLGEGGGYLHGGKYD---------NAPEGGYRVPLLIWSPGGKAKGQKSEALVSHVDLFPTILDLAGI 298
|
|
| sulfatase_like |
cd16152 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-365 |
8.50e-30 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293771 [Multi-domain] Cd Length: 373 Bit Score: 118.48 E-value: 8.50e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 46 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssigYRvlqwt 125
Cdd:cd16152 1 KPNVIVFFTDQQRWDTLGCYGQPLDLTPNLDALAEEGVLFENAFTPQPVCGPARACLQTGLYPTETGC-----FR----- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 126 gASGGLPTNETTFAKILKEKGYATGLIG---------------------------------------------------- 153
Cdd:cd16152 71 -NGIPLPADEKTLAHYFRDAGYETGYVGkwhlagyrvdaltdfaidyldnrqkdkpfflflsylephhqndrdryvapeg 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 154 ----------------------------------------RILDTLDVEGLSNSTLIYFTSDHGGSLENQlgNTQYggwn 193
Cdd:cd16152 150 saerfanfwvppdlaalpgdwaeelpdylgccerldenvgRIRDALKELGLYDNTIIVFTSDHGCHFRTR--NAEY---- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 194 giykggkGMGGWEGGIRVPGIFRWPGVLpAGRVIGEPTSLMDVFPTVVRLAGSEVPQDrvIDGQDLLPLLLGTAQHSDHE 273
Cdd:cd16152 224 -------KRSCHESSIRVPLVIYGPGFN-GGGRVEELVSLIDLPPTLLDAAGIDVPEE--MQGRSLLPLVDGKVEDWRNE 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 274 FLMHYCE----RFLHAARW----HQRDRGtmWKVHFVTPVFQPEgagacygrkvcpcfgekvvhhdppLLFDLSRDPSET 345
Cdd:cd16152 294 VFIQISEsqvgRAIRTDRWkysvAAPDKD--GWKDSGSDVYVED------------------------YLYDLEADPYEL 347
|
410 420
....*....|....*....|
gi 2462629490 346 HILtpASEPVFYQVMERVQQ 365
Cdd:cd16152 348 VNL--IGRPEYREVAAELRE 365
|
|
| sulfatase_like |
cd16155 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
45-362 |
1.64e-29 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293774 [Multi-domain] Cd Length: 372 Bit Score: 117.67 E-value: 1.64e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 45 SRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQ-HI----SAAsLCTPSRAAFLTGRYPVRSGMvssigy 119
Cdd:cd16155 1 KKPNILFILADDQRADTIGALGNPEIQTPNLDRLARRGTSFTNaYNmggwSGA-VCVPSRAMLMTGRTLFHAPE------ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 120 rvlqwtGASGGLPTNETTFAKILKEKGY---ATG---------------------------------------------- 150
Cdd:cd16155 74 ------GGKAAIPSDDKTWPETFKKAGYrtfATGkwhngfadaaiefleeykdgdkpffmyvaftaphdprqappeyldm 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 151 --------------------------------------------------------LIGRILDTLDVEGLSNSTLIYFTS 174
Cdd:cd16155 148 yppetiplpenflpqhpfdngegtvrdeqlapfprtpeavrqhlaeyyamithldaQIGRILDALEASGELDNTIIVFTS 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 175 DHG------GSLENQlgNTQYGGWngiykggkgmggweggiRVPGIFRWPGVlPAGRVIGEPTSLMDVFPTVVRLAGSEV 248
Cdd:cd16155 228 DHGlavgshGLMGKQ--NLYEHSM-----------------RVPLIISGPGI-PKGKRRDALVYLQDVFPTLCELAGIEI 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 249 PQDrvIDGQDLLPLLLG-TAQHSDHEFLMhycerFLHAARWHQRDRgtmWKVHFVTPvfqpegagacygrkvcpcfGEKV 327
Cdd:cd16155 288 PES--VEGKSLLPVIRGeKKAVRDTLYGA-----YRDGQRAIRDDR---WKLIIYVP-------------------GVKR 338
|
410 420 430
....*....|....*....|....*....|....*
gi 2462629490 328 VhhdppLLFDLSRDPSETHILtpASEPVFYQVMER 362
Cdd:cd16155 339 T-----QLFDLKKDPDELNNL--ADEPEYQERLKK 366
|
|
| sulfatase_like |
cd16153 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
46-259 |
2.43e-29 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293772 [Multi-domain] Cd Length: 282 Bit Score: 115.17 E-value: 2.43e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 46 RPNILLLMADDLGIGDIGCYGN----------NTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGM-- 113
Cdd:cd16153 1 KPNILWIITDDQRVDSLSCYNNahtgksesrlGYVESPNIDALAAEGVLFTNAYCNSPVCVPSRTSMLTGRYPHRTGVyg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 114 -------------------------VSSIG-------YRVLQ---------WTGASGGLPTNETTFAKI---------LK 143
Cdd:cd16153 81 feaahpaldhglptfpevlkkagyqTASFGkshleafQRYLKnanqsyksfWGKIAKGADSDKPFFVRLsflqphtpvLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 144 EKGYAT------------GLIGRILDTLDVEGLSN---STLIYFTSDHGGSLENQLGNTQYGGWNgiykggkgmggweGG 208
Cdd:cd16153 161 PKEFRDrfdyyafcaygdAQVGRAVEAFKAYSLKQdrdYTIVYVTGDHGWHLGEQGILAKFTFWP-------------QS 227
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 2462629490 209 IRVPGIFRWPGVL--PAGRVIGEPTSLMDVFPTVVRLAGSEVPQDRVIDGQDL 259
Cdd:cd16153 228 HRVPLIVVSSDKLkaPAGKVRHDFVEFVDLAPTLLAAAGVDVDAPDYLDGRDL 280
|
|
| PMH |
cd16028 |
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase ... |
47-372 |
4.71e-29 |
|
Phosphonate monoester hydrolase/phosphodiesterase; Phosphonate monoester hydrolase/phosphodiesterase hydrolyses phosphonate monoesters or phosphate diesters using a posttranslationally formed formylglycine as the catalytic nucleophile. PMH is the member of the alkaline phosphatase superfamily. The structure of PMH is more homologous to arylsulfatase than alkaline phosphatase. Sulfatases also use formylglycine as catalytic nucleophile.
Pssm-ID: 293752 [Multi-domain] Cd Length: 449 Bit Score: 117.75 E-value: 4.71e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMV------------ 114
Cdd:cd16028 1 RNVLFITADQWRADCLSCLGHPLVKTPNLDRLAAEGVRFRNHYTQAAPCGPSRASLYTGRYLMNHRSVwngtpldarhlt 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 115 ------------SSIGY---------------RVLQWTGASGGLPTN-----------ETTFA-----KILKEKG----- 146
Cdd:cd16028 81 lalelrkagydpALFGYtdtspdprglapldpRLLSYELAMPGFDPVdrldeypaedsDTAFLtdraiEYLDERQdepwf 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 147 ---------------------------------------------YAT-------------------------------- 149
Cdd:cd16028 161 lhlsyirphppfvapapyhalydpadvpppiraeslaaeaaqhplLAAflerieslsfspgaanaadlddeevaqmraty 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 150 -GLI-------GRILDTLDVEGLSNSTLIYFTSDHGgsleNQLGNTQYGGwngiykggkGMGGWEGGIRVPGIFRWPGVL 221
Cdd:cd16028 241 lGLIaevddhlGRLFDYLKETGQWDDTLIVFTSDHG----EQLGDHWLWG---------KDGFFDQAYRVPLIVRDPRRE 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 222 ---PAGRVIGEPTSLMDVFPTVVRLAGSEVPQDrvIDGQDLLPLLLG-------TAQHSDHEFlmhycerFLHAARWHQR 291
Cdd:cd16028 308 adaTRGQVVDAFTESVDVMPTILDWLGGEIPHQ--CDGRSLLPLLAGaqpsdwrDAVHYEYDF-------RDVSTRRPQE 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 292 DRGTmwkvhfvtpvfQPEGAGACYGRkvcpcfGE--KVVHHD--PPLLFDLSRDPSETHILtpASEPVFYQVMERVQQAV 367
Cdd:cd16028 379 ALGL-----------SPDECSLAVIR------DErwKYVHFAalPPLLFDLKNDPGELRDL--AADPAYAAVVLRYAQKL 439
|
....*
gi 2462629490 368 WEHQR 372
Cdd:cd16028 440 LSWRM 444
|
|
| iduronate-2-sulfatase |
cd16030 |
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the ... |
45-272 |
1.18e-28 |
|
iduronate-2-sulfatase; Iduronate 2-sulfatase is a sulfatase enzyme that catalyze the hydrolysis of sulfate ester bonds from a wide variety of substrates, including steroids, carbohydrates and proteins. Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in the iduronate 2-sulfatase gene that result in enzymatic deficiency lead to the sex-linked mucopolysaccharidosis type II, also known as Hunter syndrome.
Pssm-ID: 293754 [Multi-domain] Cd Length: 435 Bit Score: 116.52 E-value: 1.18e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 45 SRPNILLLMADDLGiGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGM----------- 113
Cdd:cd16030 1 KKPNVLFIAVDDLR-PWLGCYGGHPAKTPNIDRLAARGVLFTNAYCQQPVCGPSRASLLTGRRPDTTGVydnnsyfrkva 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 114 --VSSI-------GYRVL------------------QWT------------------------GASGGLPTNETTF---- 138
Cdd:cd16030 80 pdAVTLpqyfkenGYTTAgvgkifhpgipdgdddpaSWDeppnppgpekyppgklcpgkkggkGGGGGPAWEAADVpdea 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 139 ----------AKILKEKG-------------------------------------------------------------- 146
Cdd:cd16030 160 ypdgkvadeaIEQLRKLKdsdkpfflavgfykphlpfvapkkyfdlyplesiplpnpfdpidlpevawndlddlpkygdi 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 147 -----------------------------YATGLIGRILDTLDVEGLSNSTLIYFTSDHGGslenQLGntQYGGW----- 192
Cdd:cd16030 240 palnpgdpkgplpdeqarelrqayyasvsYVDAQVGRVLDALEELGLADNTIVVLWSDHGW----HLG--EHGHWgkhtl 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 193 ----NgiykggkgmggweggiRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGseVPQDRVIDGQDLLPLLLGTAQ 268
Cdd:cd16030 314 feeaT----------------RVPLIIRAPGVTKPGKVTDALVELVDIYPTLAELAG--LPAPPCLEGKSLVPLLKNPSA 375
|
....
gi 2462629490 269 HSDH 272
Cdd:cd16030 376 KWKD 379
|
|
| sulfatase_like |
cd16150 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
47-346 |
1.29e-25 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293769 [Multi-domain] Cd Length: 423 Bit Score: 107.71 E-value: 1.29e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSG-------------- 112
Cdd:cd16150 1 PNIVIFVADQLRADSLGHLGNPAAVTPNLDALAAEGVRFSNAYCQNPVCSPSRCSFLTGWYPHVNGhrtlhhllrpdepn 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 113 MVSSI---GYRVlQWTGASGGLPTNETTFA-------------------------------------------------- 139
Cdd:cd16150 81 LLKTLkdaGYHV-AWAGKNDDLPGEFAAEAycdsdeacvrtaidwlrnrrpdkpfclylplifphppygveepwfsmidr 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 140 --------KILKEKGYATGLI---------------------------------GRILDTLDVEGLSNSTLIYFTSDHG- 177
Cdd:cd16150 160 eklpprrpPGLRAKGKPSMLEgiekqgldrwseerwrelratylgmvsrldhqfGRLLEALKETGLYDDTAVFFFSDHGd 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 178 ------------GSLENQLgntqyggwngiykggkgmggweggIRVPGIFRWPGvLPAGRVIGEPTSLMDVFPTVVRLAG 245
Cdd:cd16150 240 ytgdyglvekwpNTFEDCL------------------------TRVPLIIKPPG-GPAGGVSDALVELVDIPPTLLDLAG 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 246 seVPQDRVIDGQDLLPLLLG-TAQHSDHEFlmhyCE-RFLHAARWHqrdrgtMWKVHFVTPVFQPEG----AGACYGRKV 319
Cdd:cd16150 295 --IPLSHTHFGRSLLPVLAGeTEEHRDAVF----SEgGRLHGEEQA------MEGGHGPYDLKWPRLlqqeEPPEHTKAV 362
|
410 420 430
....*....|....*....|....*....|....*.
gi 2462629490 320 cpcfgeKVVHHD---------PPLLFDLSRDPSETH 346
Cdd:cd16150 363 ------MIRTRRykyvyrlyePDELYDLEADPLELH 392
|
|
| sulfatase_like |
cd16035 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
47-278 |
4.50e-19 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293759 [Multi-domain] Cd Length: 311 Bit Score: 87.26 E-value: 4.50e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMAD------DLGIGDIGcygnntMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSI--- 117
Cdd:cd16035 1 PNILLILTDqeryppPWPAGWAA------LNLPARERLAANGLSFENHYTAACMCSPSRSTLYTGLHPQQTGVTDTLgsp 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 118 -------------------GYRVlQW------TGASGGLPTNETTFA----KILKEKG---------------------- 146
Cdd:cd16035 75 mqpllspdvptlghmlraaGYYT-AYkgkwhlSGAAGGGYKRDPGIAaqavEWLRERGaknadgkpwflvvslvnphdim 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 147 ---------------------YATGLIGRILDTLDVEGLSNSTLIYFTSDHG------GSLENqlGNTQYGgwngiykgg 199
Cdd:cd16035 154 fppddeerwrrfrnfyynlirDVDRQIGRVLDALDASGLADNTIVVFTSDHGemggahGLRGK--GFNAYE--------- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 200 kgmggweGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGSEVPQDRVID----GQDLLPLLLGTAQHSDHE-F 274
Cdd:cd16035 223 -------EALHVPLIISHPDLFGTGQTTDALTSHIDLLPTLLGLAGVDAEARATEApplpGRDLSPLLTDADADAVRDgI 295
|
....
gi 2462629490 275 LMHY 278
Cdd:cd16035 296 LFTY 299
|
|
| PRK13759 |
PRK13759 |
arylsulfatase; Provisional |
45-353 |
1.22e-18 |
|
arylsulfatase; Provisional
Pssm-ID: 237491 [Multi-domain] Cd Length: 485 Bit Score: 87.42 E-value: 1.22e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 45 SRPNILLLMADDLGiGD-IGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVS-------- 115
Cdd:PRK13759 5 KKPNIILIMVDQMR-GDcLGCNGNKAVETPNLDMLASEGYNFENAYSAVPSCTPARAALLTGLSQWHHGRVGygdvvpwn 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 116 -----------------SIG---------------------------------------YRVLQWTGASG--------GL 131
Cdd:PRK13759 84 ykntlpqefrdagyytqCIGkmhvfpqrnllgfhnvllhdgylhsgrnedksqfdfvsdYLAWLREKAPGkdpdltdiGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 132 -----------------PTNET---------------------TFAK--------------------------------- 140
Cdd:PRK13759 164 dcnswvarpwdleerlhPTNWVgsesieflrrrdptkpfflkmSFARphspydppkryfdmykdadipdphigdweyaed 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 141 -------------ILKEK-------GYATGL------IGRILDTLDVEGLSNSTLIYFTSDHGgsleNQLGNTQ------ 188
Cdd:PRK13759 244 qdpeggsidalrgNLGEEyarraraAYYGLIthidhqIGRFLQALKEFGLLDNTIILFVSDHG----DMLGDHYlfrkgy 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 189 -YGGwngiykggkgmggwegGIRVPGIFRWPG---VLPAGRVIGEPTSLMDVFPTVVRLAGSEVPQDrvIDGQDLLPLLL 264
Cdd:PRK13759 320 pYEG----------------SAHIPFIIYDPGgllAGNRGTVIDQVVELRDIMPTLLDLAGGTIPDD--VDGRSLKNLIF 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 265 G-TAQHSDHEFLMH-YCERFLHaarWHQRDR-GTMWkvHFVTPVFQpegagacygrkvcpcfgekvvhhdpplLFDLSRD 341
Cdd:PRK13759 382 GqYEGWRPYLHGEHaLGYSSDN---YLTDGKwKYIW--FSQTGEEQ---------------------------LFDLKKD 429
|
490
....*....|..
gi 2462629490 342 PSETHILTPASE 353
Cdd:PRK13759 430 PHELHNLSPSEK 441
|
|
| sulfatase_like |
cd16156 |
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the ... |
47-154 |
3.80e-18 |
|
uncharacterized sulfatase subfamily; includes Escherichia coli YidJ; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293775 [Multi-domain] Cd Length: 468 Bit Score: 85.90 E-value: 3.80e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMvssigyrvlqWTG 126
Cdd:cd16156 1 KQFIFIMTDTQRWDMVGCYGNKAMKTPNLDRLAAEGVRFDSAYTTQPVCGPARSGLFTGLYPHTNGS----------WTN 70
|
90 100
....*....|....*....|....*...
gi 2462629490 127 aSGGLPTNETTFAKILKEKGYATGLIGR 154
Cdd:cd16156 71 -CMALGDNVKTIGQRLSDNGIHTAYIGK 97
|
|
| G6S |
cd16147 |
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); ... |
46-153 |
1.10e-14 |
|
glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1); N-acetylglucosamine-6-sulfatase also known as glucosamine (N-acetyl)-6-sulfatase hydrolyzes of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate. Deficient of N-acetylglucosamine-6-sulfatase results in disease of Sanfilippo Syndrome type IIId or Mucopolysaccharidosis III (MPS-III), a rare autosomal recessive lysosomal storage disease. SULF1 encodes an extracellular heparan sulfate endosulfatase, that removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs).
Pssm-ID: 293766 [Multi-domain] Cd Length: 396 Bit Score: 74.89 E-value: 1.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 46 RPNILLLMADDLgigDIGCYGNNTMRtPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTGRYP----VRSGMVSSIGYRV 121
Cdd:cd16147 1 RPNIVLILTDDQ---DVELGSMDPMP-KTKKLLADQGTTFTNAFVTTPLCCPSRASILTGQYAhnhgVTNNSPPGGGYPK 76
|
90 100 110
....*....|....*....|....*....|..
gi 2462629490 122 LQWTGAsgglptNETTFAKILKEKGYATGLIG 153
Cdd:cd16147 77 FWQNGL------ERSTLPVWLQEAGYRTAYAG 102
|
|
| sulfatase_like |
cd16154 |
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ... |
47-154 |
2.70e-14 |
|
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293773 [Multi-domain] Cd Length: 372 Bit Score: 73.54 E-value: 2.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADDLGIGDIGCYGNNTM--RTPNIDRLAEDGVKLTqHISAASLCTPSRAAFLTGRYPVRSGmVSSIGYRVLQw 124
Cdd:cd16154 1 PNILLIIADDQGLDSSAQYSLSSDlpVTPTLDSLANSGIVFD-NLWATPACSPTRATILTGKYGFRTG-VLAVPDELLL- 77
|
90 100 110
....*....|....*....|....*....|...
gi 2462629490 125 tgasgglpTNETTFAKILKE---KGYATGLIGR 154
Cdd:cd16154 78 --------SEETLLQLLIKDattAGYSSAVIGK 102
|
|
| ARSK |
cd16171 |
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a ... |
132-343 |
1.43e-11 |
|
arylsulfatase family, member K ....arylsulfatase k short ask flags precursor; ARSK is a lysosomal sulfatase which exhibits an acidic pH optimum for catalytic activity against arylsulfate substrates. Other names for ARSK include arylsulfatase K and TSULF. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.
Pssm-ID: 293781 [Multi-domain] Cd Length: 366 Bit Score: 65.26 E-value: 1.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 132 PTNETTFAKILKEKGY-------ATGLIGRILDTLDVEGLSNSTLIYFTSDHGgslENQLGNTQYggwngiykggKGMGG 204
Cdd:cd16171 182 PSMGENFGSIRNIRAFyyamcaeTDAMLGEIISALKDTGLLDKTYVFFTSDHG---ELAMEHRQF----------YKMSM 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 205 WEGGIRVPGIFRWPGVlPAGRVIGEPTSLMDVFPTVVRLAGSEVPQDrvIDGQDLLPLLLGTAQHSDH-----------E 273
Cdd:cd16171 249 YEGSSHVPLLIMGPGI-KAGQQVSDVVSLVDIYPTMLDIAGVPQPQN--LSGYSLLPLLSESSIKESPsrvphpdwvlsE 325
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 274 FlmHYCErfLHAARWHQRDrgTMWKvhFVTpvfqpegagacYGRkvcpcfGEKVvhhdPPLLFDLSRDPS 343
Cdd:cd16171 326 F--HGCN--VNASTYMLRT--NSWK--YIA-----------YAD------GNSV----PPQLFDLSKDPD 366
|
|
| YejM |
COG3083 |
Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily [Cell wall ... |
147-260 |
3.75e-08 |
|
Periplasmic protein PbgA/YejM, regulator of the LPS biosynthesis, AlkP superfamily [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];
Pssm-ID: 442317 [Multi-domain] Cd Length: 603 Bit Score: 55.30 E-value: 3.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 147 YATGLIGRILDTLDVEGLSNSTLIYFTSDHGGSL----ENQLG-NTQYGGWNgiykggkgmggweggIRVPGIFRWPGVL 221
Cdd:COG3083 435 YVDSQIGRVLDTLEQRGLLENTIVIITADHGEEFnengQNYWGhNSNFSRYQ---------------LQVPLVIHWPGTP 499
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 2462629490 222 PagRVIGEPTSLMDVFPTVV-RLAGSEVPqdrVID---GQDLL 260
Cdd:COG3083 500 P--QVISKLTSHLDIVPTLMqRLLGVQNP---ASDysqGEDLF 537
|
|
| MdoB |
COG1368 |
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ... |
152-260 |
1.68e-06 |
|
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440979 [Multi-domain] Cd Length: 576 Bit Score: 50.04 E-value: 1.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 152 IGRILDTLDVEGLSNSTLIYFTSDHGGSLEnqlGNTQYggwngiykggkgmGGWEGGIRVPGIFRWPGvLPAGRVIGEPT 231
Cdd:COG1368 430 LGEFIEKLKKSGWYDNTIFVIYGDHGPRSP---GKTDY-------------ENPLERYRVPLLIYSPG-LKKPKVIDTVG 492
|
90 100
....*....|....*....|....*....
gi 2462629490 232 SLMDVFPTVVRLAGSEVPQDRVIdGQDLL 260
Cdd:COG1368 493 SQIDIAPTLLDLLGIDYPSYYAF-GRDLL 520
|
|
| AtaC |
COG1524 |
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal ... |
28-153 |
9.16e-06 |
|
c-di-AMP phosphodiesterase AtaC or nucleotide pyrophosphatase, AlkP superfamily [Signal transduction mechanisms];
Pssm-ID: 441133 [Multi-domain] Cd Length: 370 Bit Score: 47.44 E-value: 9.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 28 LAVLLSLAPSASSDISASRPNILLLMADDLGIGDIgcygnNTMRTPNIDRLAEDGVKLTQHISAA-SLCTPSRAAFLTGR 106
Cdd:COG1524 5 LSLLLASLLAAAAAAAPPAKKVVLILVDGLRADLL-----ERAHAPNLAALAARGVYARPLTSVFpSTTAPAHTTLLTGL 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 2462629490 107 YPVRSGMVSSIGYR--------VLQWTGASGGLPT--NETTFAKILKEKGYATGLIG 153
Cdd:COG1524 80 YPGEHGIVGNGWYDpelgrvvnSLSWVEDGFGSNSllPVPTIFERARAAGLTTAAVF 136
|
|
| LTA_synthase |
cd16015 |
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ... |
47-149 |
4.10e-04 |
|
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.
Pssm-ID: 293739 [Multi-domain] Cd Length: 283 Bit Score: 41.90 E-value: 4.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 47 PNILLLMADdlGIGD--IGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRA--AFLTGRYPVRSGMVSSIGYRvl 122
Cdd:cd16015 1 PNVIVILLE--SFSDpyIDKDVGGEDLTPNLNKLAKEGLYFGNFYSPGFGGGTANGefEVLTGLPPLPLGSGSYTLYK-- 76
|
90 100
....*....|....*....|....*..
gi 2462629490 123 qwtgasgglPTNETTFAKILKEKGYAT 149
Cdd:cd16015 77 ---------LNPLPSLPSILKEQGYET 94
|
|
| LTA_synthase |
cd16015 |
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ... |
152-245 |
5.36e-04 |
|
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.
Pssm-ID: 293739 [Multi-domain] Cd Length: 283 Bit Score: 41.51 E-value: 5.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462629490 152 IGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIykggkgmggweggiRVPGIFRWPGVLPaGRVIGEPT 231
Cdd:cd16015 205 LGEFIEKLKKSGLYENTIIVIYGDHLPSLGSDYDETDEDPLDLY--------------RTPLLIYSPGLKK-PKKIDRVG 269
|
90
....*....|....
gi 2462629490 232 SLMDVFPTVVRLAG 245
Cdd:cd16015 270 SQIDIAPTLLDLLG 283
|
|
| Phosphodiest |
pfam01663 |
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of ... |
71-115 |
1.97e-03 |
|
Type I phosphodiesterase / nucleotide pyrophosphatase; This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity. The alignment encompasses the active site. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum.
Pssm-ID: 396300 [Multi-domain] Cd Length: 343 Bit Score: 40.10 E-value: 1.97e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 2462629490 71 RTPNIDRLAEDGVKLTQHISAA-SLCTPSRAAFLTGRYPVRSGMVS 115
Cdd:pfam01663 19 LTPNLAALAKEGVSAPNLTPVFpTLTFPNHYTLVTGLYPGSHGIVG 64
|
|
| |
