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Conserved domains on  [gi|2462490141|ref|XP_054184843|]
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solute carrier family 22 member 18 isoform X7 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 25-289 2.01e-81

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17331:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 382  Bit Score: 250.98  E-value: 2.01e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  25 VILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYL 104
Cdd:cd17331     1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 105 LLAAAsspalPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPA 184
Cdd:cd17331    81 LLAFA-----SSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 185 ILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPraSVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSII 264
Cdd:cd17331   156 LVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPP--SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLV 233

                         250       260
                  ....*....|....*....|....*
gi 2462490141 265 SMDFFQLEAAQAGYLMSFFGLLQMA 289
Cdd:cd17331   234 AMDFFGLTPEENGYLMSYAGVLGMV 258
 
Name Accession Description Interval E-value
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 25-289 2.01e-81

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 250.98  E-value: 2.01e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  25 VILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYL 104
Cdd:cd17331     1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 105 LLAAAsspalPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPA 184
Cdd:cd17331    81 LLAFA-----SSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 185 ILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPraSVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSII 264
Cdd:cd17331   156 LVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPP--SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLV 233

                         250       260
                  ....*....|....*....|....*
gi 2462490141 265 SMDFFQLEAAQAGYLMSFFGLLQMA 289
Cdd:cd17331   234 AMDFFGLTPEENGYLMSYAGVLGMV 258
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-289 3.85e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 65.77  E-value: 3.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  18 SALGRSSVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFL 97
Cdd:COG2814     4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  98 AALALYLLLaaassPALPGVYLLFASRLPGALMHTL--PAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLV 175
Cdd:COG2814    84 LFALGSLLC-----ALAPSLWLLLAARFLQGLGAGAlfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 176 SAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAplpggprasvfdlkAIASLLRLPDVPRIFLVKVASNCPTG 255
Cdd:COG2814   159 DLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRG--------------SLRELLRRPRLLLLLLLAFLLGFGFF 224

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2462490141 256 LFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMA 289
Cdd:COG2814   225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVL 258
MFS_1 pfam07690
Major Facilitator Superfamily;
26-286 2.52e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 54.35  E-value: 2.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  26 ILLTYVLAATELTCLFmqFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLL 105
Cdd:pfam07690   1 LFLAAFLAALGRSLLG--PALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 106 LAAAsspalPGVYLLFASRLPGALMH--TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQcp 183
Cdd:pfam07690  79 LLFA-----SSLWLLLVLRVLQGLGAgaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR-- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 184 ailaaLATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSI 263
Cdd:pfam07690 152 -----AAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226

                         250       260
                  ....*....|....*....|...
gi 2462490141 264 isMDFFQLEAAQAGYLMSFFGLL 286
Cdd:pfam07690 227 --QEVLGLSALLAGLLLGLGGLL 247
 
Name Accession Description Interval E-value
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 25-289 2.01e-81

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 250.98  E-value: 2.01e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  25 VILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYL 104
Cdd:cd17331     1 VLLIVHLNIVLYATCYWLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 105 LLAAAsspalPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPA 184
Cdd:cd17331    81 LLAFA-----SSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 185 ILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPraSVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSII 264
Cdd:cd17331   156 LVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPP--SVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLV 233

                         250       260
                  ....*....|....*....|....*
gi 2462490141 265 SMDFFQLEAAQAGYLMSFFGLLQMA 289
Cdd:cd17331   234 AMDFFGLTPEENGYLMSYAGVLGMV 258
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 30-288 7.58e-27

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 107.66  E-value: 7.58e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  30 YVLAATELTCLFMQFSIVPYLSR---KLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLL 106
Cdd:cd17330     2 FLVVFLDALGFGIVFPVLPFYVRefnKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 107 AAasspALPGVYLLFASRLPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAIL 186
Cdd:cd17330    82 GL----SRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 187 AalatllgavlsftcipastkgaktdaqaplpggprASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISM 266
Cdd:cd17330   158 A-----------------------------------AALALLNLVLVLFFLPPLRRLLLVYFLIALAFAGLESVFSLFLK 202

                         250       260
                  ....*....|....*....|..
gi 2462490141 267 DFFQLEAAQAGYLMSFFGLLQM 288
Cdd:cd17330   203 DRFGFSPSQIGLLLALVGIAGI 224
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 30-289 1.37e-13

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 69.95  E-value: 1.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  30 YVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAA 109
Cdd:cd17390     2 YLVGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 110 SSpalpgVYLLFASRLP-GALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGiqcpailaa 188
Cdd:cd17390    82 TS-----LALLFLSRIPlGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDG--------- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 189 latlLGAVLSFTCipastkgaktdaqaplpggprASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDF 268
Cdd:cd17390   148 ----GFYYVALLC---------------------SAIFILNAGLVWFLLSKLWDLLLVRFLMGFSVLLFRSNFSLYLEER 202

                         250       260
                  ....*....|....*....|.
gi 2462490141 269 FQLEAAQAGYLMSFFGLLQMA 289
Cdd:cd17390   203 FDLSPKTIGYLISYSGVLGAL 223
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
18-289 3.85e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 65.77  E-value: 3.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  18 SALGRSSVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFL 97
Cdd:COG2814     4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  98 AALALYLLLaaassPALPGVYLLFASRLPGALMHTL--PAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLV 175
Cdd:COG2814    84 LFALGSLLC-----ALAPSLWLLLAARFLQGLGAGAlfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 176 SAYGIQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAplpggprasvfdlkAIASLLRLPDVPRIFLVKVASNCPTG 255
Cdd:COG2814   159 DLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRG--------------SLRELLRRPRLLLLLLLAFLLGFGFF 224

                         250       260       270
                  ....*....|....*....|....*....|....
gi 2462490141 256 LFMVMFSIISMDFFQLEAAQAGYLMSFFGLLQMA 289
Cdd:COG2814   225 ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVL 258
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 42-285 1.75e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 57.97  E-value: 1.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  42 MQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALpgvyLLF 121
Cdd:cd17325    14 IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ----LLL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 122 ASRLPGALMH-TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGAVLSFT 200
Cdd:cd17325    90 ARFLQGLASAaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALL 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 201 CIPASTKGAKTdaqaplpgGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQAGYLM 280
Cdd:cd17325   170 LLPEPRPPPNK--------RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLF 241


                  ....*
gi 2462490141 281 SFFGL 285
Cdd:cd17325   242 GAQGL 246
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 25-287 2.37e-08

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 54.56  E-value: 2.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  25 VILLTYVLAATELTcLFMqfSIVPYLSRKLGLDSIA----FGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAAL 100
Cdd:cd17388     3 FILVTVLLDAMGIG-LIM--PVLPTLLREFVGDSADaathYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 101 ALYLLLAAAsspalPGVYLLFASRLPGALM-HTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGtLVSAYG 179
Cdd:cd17388    80 LDYLLMAFA-----PTLWWLYLGRIIAGITgATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGG-LLGEIS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 180 IQCPAILAALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVprIFLVKVASNCPtglfMV 259
Cdd:cd17388   154 PRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAV--FFLIQLIGQVP----AT 227

                         250       260
                  ....*....|....*....|....*...
gi 2462490141 260 MFSIISMDFFQLEAAQAGYLMSFFGLLQ 287
Cdd:cd17388   228 TWVLFTEDRFDWSPTMVGLSLAVFGLLH 255
MFS_1 pfam07690
Major Facilitator Superfamily;
26-286 2.52e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 54.35  E-value: 2.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  26 ILLTYVLAATELTCLFmqFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLL 105
Cdd:pfam07690   1 LFLAAFLAALGRSLLG--PALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 106 LAAAsspalPGVYLLFASRLPGALMH--TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQcp 183
Cdd:pfam07690  79 LLFA-----SSLWLLLVLRVLQGLGAgaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR-- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 184 ailaaLATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSI 263
Cdd:pfam07690 152 -----AAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226

                         250       260
                  ....*....|....*....|...
gi 2462490141 264 isMDFFQLEAAQAGYLMSFFGLL 286
Cdd:pfam07690 227 --QEVLGLSALLAGLLLGLGGLL 247
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-181 1.23e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 49.11  E-value: 1.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141   1 MQGARAPRDQGQSPGRMSALGRSSVILLTYVLAATELTCLFMQFSIVP-YLSRKLGLDSIAFGYLQTTFGVLQLLGGPVF 79
Cdd:cd17325   176 PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPA 255

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  80 GRFADQRGARAALTLSFLAALALYLLLaaassPALPGVYLLFASRLPGALMHTL--PAAQMVITDLSAPEERPAALGRLG 157
Cdd:cd17325   256 GKLSDRIGRKPLILIGLLLSAVALLLL-----PLATSFWLLLLLLALLGLGLGLvfPATLALLADIVPPEGRGTAMGLFN 330

                         170       180
                  ....*....|....*....|....
gi 2462490141 158 LCFGVGVILGSLLGGTLVSAYGIQ 181
Cdd:cd17325   331 TAFSLGMVLGPLLGGFLYDAFGFA 354
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 30-289 1.27e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 46.27  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  30 YVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAaa 109
Cdd:cd06174     2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA-- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 110 sspALPGVYLLFASRLPGALMHTL--PAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIqcpaILA 187
Cdd:cd06174    80 ---FAPSFWLLLLGRFLLGLGSGLidPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF----GWR 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 188 ALATLLGAVLSFTCIPASTKGAKTDAQAPLPGGPRASVFDLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMD 267
Cdd:cd06174   153 AVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD 232

                         250       260
                  ....*....|....*....|..
gi 2462490141 268 FFQLEAAQAGYLMSFFGLLQMA 289
Cdd:cd06174   233 LGGLSVAVAGLLLSLFGLAGAL 254
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
24-181 6.41e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 44.09  E-value: 6.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  24 SVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALY 103
Cdd:COG2271   181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAAL 260

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462490141 104 LLLAAASSPALPGVYLLFAsrLPGALMH-TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQ 181
Cdd:COG2271   261 ALLLLALLPSPALAIALLF--LAGFGLGgAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
46-286 7.98e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.72  E-value: 7.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  46 IVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAAlalylllaaasspALPGVYLLFASRL 125
Cdd:COG2223    27 LAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL-------------GIGLLLLALAVSY 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 126 PGALMH----------TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYGIQCPAILAALATLLGA 195
Cdd:COG2223    94 WLLLLLglllgiggggSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 196 VLSFTCIPASTKGAKTDAQAPlpggprasvfdLKAIASLLRLPDVPRIFLVKVASNCPTGLFMVMFSIISMDFFQLEAAQ 275
Cdd:COG2223   174 VLAWLFLRDPPAGAAAAAKAS-----------LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAAT 242

                         250
                  ....*....|.
gi 2462490141 276 AGYLMSFFGLL 286
Cdd:COG2223   243 AGLLAALFALL 253
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
7-163 8.22e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.42  E-value: 8.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141   7 PRDQGQSPGRMSALGRSSVILLTYVLAATELTCLFMQFSIVP-YLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQ 85
Cdd:COG2814   190 PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPlYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR 269

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462490141  86 RGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASrlpGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVG 163
Cdd:COG2814   270 FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLG---FGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 15-179 1.28e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 42.92  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  15 GRMSALGRSSVILLTYVLAATELTCLFMQFS-IVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALT 93
Cdd:cd17324   189 SSLLLLLRNPRLRLAYLITFLLFGGFFALYTyLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  94 LSFLAALALYLLLAAASSPALPGVYLLFASrlpGALMHTLPAAQMVITDLsAPEERPAALGRLGLCFGVGVILGSLLGGT 173
Cdd:cd17324   269 ALLLLAAALLLLTLLGPSPLLLLVGLVLWG---LGFFAAHSALQTRVLRL-APEARGLASSLYLAAYNLGGALGAALGGL 344


                  ....*.
gi 2462490141 174 LVSAYG 179
Cdd:cd17324   345 VLDHGG 350
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 13-179 5.83e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 40.95  E-value: 5.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  13 SPGRMSALGRSSVILLTYVLAATELTCLFMQFSIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAAL 92
Cdd:COG0477     3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  93 TLSFLAALALYLLLAaasspALPGVYLLFASR----LPGALMhtLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGS 168
Cdd:COG0477    83 LIGLLLFGLASLLCG-----LAPSPELLIAARalqgIGAGGL--MPGALALIAELFPARERGRALGLWGAAIGLGLALGP 155

                         170
                  ....*....|.
gi 2462490141 169 LLGGTLVSAYG 179
Cdd:COG0477   156 LLGGLLVAALG 166
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 45-179 1.18e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 40.30  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  45 SIVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADqRGARAALTLSFLAALALYLLLAaassPALPGVYLLFASR 124
Cdd:cd17328    20 GVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGD-RYNRKWILAVGILIWSAATLLS----SFAPNFWQLLLFR 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141 125 lpgALMHT-----LPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYG 179
Cdd:cd17328    95 ---ALVGIgeasySPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG 151
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 49-178 1.64e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.52  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  49 YLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAAASSPALPGVYLLFASrLPGA 128
Cdd:cd17329    25 YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTG-FGGG 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462490141 129 LMHtlPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAY 178
Cdd:cd17329   104 LFE--PASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS 151
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
46-179 1.95e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.47  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  46 IVPYLSRKLGLDSIAFGYLQTTFGVLQLLGGPVFGRFADQRGARAALTLSFLAALALYLLLAaasspALPGVYLLFASRL 125
Cdd:COG2271    32 AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG-----FATSFWQLLLLRF 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462490141 126 PGALMH--TLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSAYG 179
Cdd:COG2271   107 LLGLGEagFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG 162
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 25-177 5.95e-03

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 37.96  E-value: 5.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490141  25 VILLTYVLAATELTCLFMqfSIVPYLSrKLGLDSIA--FGYLQTTFGVLQLLGGPVFGRFADQRG-ARAALTLSFLAALA 101
Cdd:cd17326     3 VMYLTMFLSSLQFSIVLT--SIWPYLQ-KIDPTATAsfFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462490141 102 LYLLLAAASSPALPGVYLLFASR-LPGALMHTLPAAQMVITDLSAPEERPAALGRLGLCFGVGVILGSLLGGTLVSA 177
Cdd:cd17326    80 GNILYALAEYFPSNRKYVMLVARfLIGVGAGNVAVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPI 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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