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Conserved domains on  [gi|2462490803|ref|XP_054185552|]
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liver carboxylesterase 1 isoform X1 [Homo sapiens]

Protein Classification

carboxylesterase/lipase family protein( domain architecture ID 10444481)

carboxylesterase/lipase family protein similar to carboxylesterase, which catalyzes the hydrolysis of a carboxylic ester to form an alcohol and a carboxylate

CATH:  3.40.50.1820
EC:  3.1.1.-
Gene Ontology:  GO:0052689
PubMed:  8453375|3163407|8280778|9704093|11099800|37582413|31545554
SCOP:  3000102|4000699

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
23-547 0e+00

Carboxylesterase family;


:

Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 634.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803  23 SPPVVDTVHGKVLGKFVSLEGFaQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQllself 102
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGG-KPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 103 tnrKENIPLKLSEDCLYLNIYTPADLTK-KNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST 181
Cdd:pfam00135  74 ---PGSSGLEGSEDCLYLNVYTPKELKEnKNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLST 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 182 GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGD 261
Cdd:pfam00135 151 GDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 262 VKpLAEQIAITAGCKTTTSAVMVHCLRQKTEeellettlkMKFLSLDLQGDPRESQPLL--GTVIDGMLLLKTPEELQAE 339
Cdd:pfam00135 231 RQ-RAKELAKLVGCPTSDSAELVECLRSKPA---------EELLDAQLKLLVYGSVPFVpfGPVVDGDFLPEHPEELLKS 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 340 RNFHTVPYMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAK--ELIPEATEKYL--GGTDDTVKKKD 415
Cdd:pfam00135 301 GNFPKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLVDLpeEISAALREEYLdwGDRDDPETSRR 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 416 LFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSsdMKPKTVIGDHGDELFSVFGAPFL-KEGASEEEIRLSK 494
Cdd:pfam00135 381 ALVELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVgALLFTEEDEKLSR 458

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462490803 495 MVMKFWANFARNGNPNG-EGLPHWPEYNQKEG-YLQIGANTQAAQKLKDKEVAFW 547
Cdd:pfam00135 459 KMMTYWTNFAKTGNPNGpEGLPKWPPYTDENGqYLSIDLEPRVKQGLKAERCAFW 513
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
23-547 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 634.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803  23 SPPVVDTVHGKVLGKFVSLEGFaQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQllself 102
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGG-KPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 103 tnrKENIPLKLSEDCLYLNIYTPADLTK-KNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST 181
Cdd:pfam00135  74 ---PGSSGLEGSEDCLYLNVYTPKELKEnKNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLST 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 182 GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGD 261
Cdd:pfam00135 151 GDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 262 VKpLAEQIAITAGCKTTTSAVMVHCLRQKTEeellettlkMKFLSLDLQGDPRESQPLL--GTVIDGMLLLKTPEELQAE 339
Cdd:pfam00135 231 RQ-RAKELAKLVGCPTSDSAELVECLRSKPA---------EELLDAQLKLLVYGSVPFVpfGPVVDGDFLPEHPEELLKS 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 340 RNFHTVPYMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAK--ELIPEATEKYL--GGTDDTVKKKD 415
Cdd:pfam00135 301 GNFPKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLVDLpeEISAALREEYLdwGDRDDPETSRR 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 416 LFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSsdMKPKTVIGDHGDELFSVFGAPFL-KEGASEEEIRLSK 494
Cdd:pfam00135 381 ALVELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVgALLFTEEDEKLSR 458

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462490803 495 MVMKFWANFARNGNPNG-EGLPHWPEYNQKEG-YLQIGANTQAAQKLKDKEVAFW 547
Cdd:pfam00135 459 KMMTYWTNFAKTGNPNGpEGLPKWPPYTDENGqYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 26-538 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 595.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803  26 VVDTVHGKVLGKFVSlegfaqPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLselftnr 105
Cdd:cd00312     1 LVVTPNGKVRGVDEG------GVYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGL------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 106 kENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAA-HENVVVVTIQYRLGIWGFFSTGDE 184
Cdd:cd00312    68 -WNAKLPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAReGDNVIVVSINYRLGVLGFLSTGDI 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 185 HSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGdVKP 264
Cdd:cd00312   147 ELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQEN-ARG 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 265 LAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGdpresqpLLGTVIDGMLLLKTPEELQAERNFHT 344
Cdd:cd00312   226 RAKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLLFSYSPFL-------PFGPVVDGDFIPDDPEELIKEGKFAK 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 345 VPYMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSLLwkSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDLIADV 424
Cdd:cd00312   299 VPLIIGVTKDEGGYFAAMLLNFDAKLIIETNDRWLELL--PYLLFYADDALADKVLEKYPGDVDDSVESRKNLSDMLTDL 376

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 425 MFGVPSVIVARNHRDA-GAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWANF 503
Cdd:cd00312   377 LFKCPARYFLAQHRKAgGSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLLKEGLREEEEKLSRTMMKYWANF 456

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 2462490803 504 ARNGNPNGEG-LPHWPEYN-QKEGYLQIGANTQAAQK 538
Cdd:cd00312   457 AKTGNPNTEGnLVVWPAYTsESEKYLDINIEGTEIKQ 493
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
19-551 2.30e-155

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 453.96  E-value: 2.30e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803  19 GHPSSPPVVDTVHGKVLGkfVSLEGfaqpVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLL 98
Cdd:COG2272     7 AAAAAAPVVRTEAGRVRG--VVEGG----VRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRPGDPG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803  99 SelftnrkeniPLKLSEDCLYLNIYTPADLTKKnRLPVMVWIHGGGLMVGAAST--YDGLALAAhENVVVVTIQYRLGIW 176
Cdd:COG2272    81 G----------PAPGSEDCLYLNVWTPALAAGA-KLPVMVWIHGGGFVSGSGSEplYDGAALAR-RGVVVVTINYRLGAL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 177 GFF-----STGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVA 251
Cdd:COG2272   149 GFLalpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAG 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 252 LTsvLVKKGDVKPLAEQIAITAGCKTTTSAvmvhCLRQKTEEellettlkmKFLSLDLQGDPRESQPL-LGTVIDGMLLL 330
Cdd:COG2272   229 LS--VLTLAEAEAVGAAFAAALGVAPATLA----ALRALPAE---------ELLAAQAALAAEGPGGLpFGPVVDGDVLP 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 331 KTPEELQAERNFHTVPYMVGINKQEFGWLIPML-MSYPLSEGQLDQktamsLLWKSYPlvciakELIPEATEKYLGGTDd 409
Cdd:COG2272   294 EDPLEAFAAGRAADVPLLIGTNRDEGRLFAALLgDLGPLTAADYRA-----ALRRRFG------DDADEVLAAYPAASP- 361

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 410 tvkkKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVigdHGDELFSVFG--APFLKEGASE 487
Cdd:COG2272   362 ----AEALAALATDRVFRCPARRLAEAHAAAGAPVYLYRFDWRSPPLRGFGLGAF---HGAELPFVFGnlDAPALTGLTP 434

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462490803 488 EEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEG-YLQIGANTQAAQKLKDKE-VAFWTNLF 551
Cdd:COG2272   435 ADRALSDQMQAYWVNFARTGDPNGPGLPEWPAYDPEDRaVMVFDAEPRVVNDPDAEErLDLWDGVV 500
PRK10162 PRK10162
acetyl esterase;
136-224 1.17e-04

acetyl esterase;


Pssm-ID: 236660 [Multi-domain]  Cd Length: 318  Bit Score: 44.32  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 136 VMVWIHGGGLMVGAASTYDGLA--LAAHENVVVVTIQYRLGIWGFFSTGDEHSrgnwghldqVAALRWVQDNIASFGGNP 213
Cdd:PRK10162   83 TLFYLHGGGFILGNLDTHDRIMrlLASYSGCTVIGIDYTLSPEARFPQAIEEI---------VAVCCYFHQHAEDYGINM 153

                          90
                  ....*....|.
gi 2462490803 214 GSVTIFGESAG 224
Cdd:PRK10162  154 SRIGFAGDSAG 164
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
23-547 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 634.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803  23 SPPVVDTVHGKVLGKFVSLEGFaQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQllself 102
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGG-KPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 103 tnrKENIPLKLSEDCLYLNIYTPADLTK-KNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST 181
Cdd:pfam00135  74 ---PGSSGLEGSEDCLYLNVYTPKELKEnKNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLST 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 182 GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGD 261
Cdd:pfam00135 151 GDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 262 VKpLAEQIAITAGCKTTTSAVMVHCLRQKTEeellettlkMKFLSLDLQGDPRESQPLL--GTVIDGMLLLKTPEELQAE 339
Cdd:pfam00135 231 RQ-RAKELAKLVGCPTSDSAELVECLRSKPA---------EELLDAQLKLLVYGSVPFVpfGPVVDGDFLPEHPEELLKS 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 340 RNFHTVPYMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAK--ELIPEATEKYL--GGTDDTVKKKD 415
Cdd:pfam00135 301 GNFPKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLVDLpeEISAALREEYLdwGDRDDPETSRR 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 416 LFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSsdMKPKTVIGDHGDELFSVFGAPFL-KEGASEEEIRLSK 494
Cdd:pfam00135 381 ALVELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSL--RYPKWVGVDHGDELPYVFGTPFVgALLFTEEDEKLSR 458

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2462490803 495 MVMKFWANFARNGNPNG-EGLPHWPEYNQKEG-YLQIGANTQAAQKLKDKEVAFW 547
Cdd:pfam00135 459 KMMTYWTNFAKTGNPNGpEGLPKWPPYTDENGqYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 26-538 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 595.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803  26 VVDTVHGKVLGKFVSlegfaqPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLselftnr 105
Cdd:cd00312     1 LVVTPNGKVRGVDEG------GVYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGL------- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 106 kENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAA-HENVVVVTIQYRLGIWGFFSTGDE 184
Cdd:cd00312    68 -WNAKLPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAReGDNVIVVSINYRLGVLGFLSTGDI 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 185 HSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGdVKP 264
Cdd:cd00312   147 ELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQEN-ARG 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 265 LAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGdpresqpLLGTVIDGMLLLKTPEELQAERNFHT 344
Cdd:cd00312   226 RAKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLLFSYSPFL-------PFGPVVDGDFIPDDPEELIKEGKFAK 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 345 VPYMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSLLwkSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDLIADV 424
Cdd:cd00312   299 VPLIIGVTKDEGGYFAAMLLNFDAKLIIETNDRWLELL--PYLLFYADDALADKVLEKYPGDVDDSVESRKNLSDMLTDL 376

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 425 MFGVPSVIVARNHRDA-GAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWANF 503
Cdd:cd00312   377 LFKCPARYFLAQHRKAgGSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLLKEGLREEEEKLSRTMMKYWANF 456

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 2462490803 504 ARNGNPNGEG-LPHWPEYN-QKEGYLQIGANTQAAQK 538
Cdd:cd00312   457 AKTGNPNTEGnLVVWPAYTsESEKYLDINIEGTEIKQ 493
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
19-551 2.30e-155

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 453.96  E-value: 2.30e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803  19 GHPSSPPVVDTVHGKVLGkfVSLEGfaqpVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLL 98
Cdd:COG2272     7 AAAAAAPVVRTEAGRVRG--VVEGG----VRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRPGDPG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803  99 SelftnrkeniPLKLSEDCLYLNIYTPADLTKKnRLPVMVWIHGGGLMVGAAST--YDGLALAAhENVVVVTIQYRLGIW 176
Cdd:COG2272    81 G----------PAPGSEDCLYLNVWTPALAAGA-KLPVMVWIHGGGFVSGSGSEplYDGAALAR-RGVVVVTINYRLGAL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 177 GFF-----STGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVA 251
Cdd:COG2272   149 GFLalpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAG 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 252 LTsvLVKKGDVKPLAEQIAITAGCKTTTSAvmvhCLRQKTEEellettlkmKFLSLDLQGDPRESQPL-LGTVIDGMLLL 330
Cdd:COG2272   229 LS--VLTLAEAEAVGAAFAAALGVAPATLA----ALRALPAE---------ELLAAQAALAAEGPGGLpFGPVVDGDVLP 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 331 KTPEELQAERNFHTVPYMVGINKQEFGWLIPML-MSYPLSEGQLDQktamsLLWKSYPlvciakELIPEATEKYLGGTDd 409
Cdd:COG2272   294 EDPLEAFAAGRAADVPLLIGTNRDEGRLFAALLgDLGPLTAADYRA-----ALRRRFG------DDADEVLAAYPAASP- 361

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 410 tvkkKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVigdHGDELFSVFG--APFLKEGASE 487
Cdd:COG2272   362 ----AEALAALATDRVFRCPARRLAEAHAAAGAPVYLYRFDWRSPPLRGFGLGAF---HGAELPFVFGnlDAPALTGLTP 434

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462490803 488 EEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEG-YLQIGANTQAAQKLKDKE-VAFWTNLF 551
Cdd:COG2272   435 ADRALSDQMQAYWVNFARTGDPNGPGLPEWPAYDPEDRaVMVFDAEPRVVNDPDAEErLDLWDGVV 500
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
122-225 1.21e-20

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 90.32  E-value: 1.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 122 IYTPADLTKKnrLPVMVWIHGGGLMVGAASTYDGLA--LAAHENVVVVTIQYRLGiwgffstgDEHSrgnW-GHLDQV-A 197
Cdd:COG0657     3 VYRPAGAKGP--LPVVVYFHGGGWVSGSKDTHDPLArrLAARAGAAVVSVDYRLA--------PEHP---FpAALEDAyA 69

                          90       100
                  ....*....|....*....|....*...
gi 2462490803 198 ALRWVQDNIASFGGNPGSVTIFGESAGG 225
Cdd:COG0657    70 ALRWLRANAAELGIDPDRIAVAGDSAGG 97
Abhydrolase_3 pfam07859
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 137-225 1.54e-14

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 400284 [Multi-domain]  Cd Length: 208  Bit Score: 72.63  E-value: 1.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 137 MVWIHGGGLMVGAASTYDGLA--LAAHENVVVVTIQYRLgiwgffstGDEHSrgnW--GHLDQVAALRWVQDNIASFGGN 212
Cdd:pfam07859   1 LVYFHGGGFVLGSADTHDRLCrrLAAEAGAVVVSVDYRL--------APEHP---FpaAYDDAYAALRWLAEQAAELGAD 69

                          90
                  ....*....|...
gi 2462490803 213 PGSVTIFGESAGG 225
Cdd:pfam07859  70 PSRIAVAGDSAGG 82
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
122-251 2.68e-10

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 60.80  E-value: 2.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 122 IYTPADltkKNRLPVMVWIHGGGlmVGAASTYDGLALAAHEN-VVVVTIQYRlgiwgffstGDEHSRGNWGHL---DQVA 197
Cdd:COG1506    14 LYLPAD---GKKYPVVVYVHGGP--GSRDDSFLPLAQALASRgYAVLAPDYR---------GYGESAGDWGGDevdDVLA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462490803 198 ALRWVqdnIASFGGNPGSVTIFGESAGGesVSVLVLSPLAKNLFHRAISESGVA 251
Cdd:COG1506    80 AIDYL---AARPYVDPDRIGIYGHSYGG--YMALLAAARHPDRFKAAVALAGVS 128
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 120-225 4.69e-09

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 56.80  E-value: 4.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 120 LNIYTPAdlTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENV-----VVVTIQYRLgiwgffsTGDEHSRgnwghlD 194
Cdd:pfam20434   1 LDIYLPK--NAKGPYPVVIWIHGGGWNSGDKEADMGFMTNTVKALlkagyAVASINYRL-------STDAKFP------A 65

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 2462490803 195 QV----AALRWVQDNIASFGGNPGSVTIFGESAGG 225
Cdd:pfam20434  66 QIqdvkAAIRFLRANAAKYGIDTNKIALMGFSAGG 100
PRK10162 PRK10162
acetyl esterase;
136-224 1.17e-04

acetyl esterase;


Pssm-ID: 236660 [Multi-domain]  Cd Length: 318  Bit Score: 44.32  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 136 VMVWIHGGGLMVGAASTYDGLA--LAAHENVVVVTIQYRLGIWGFFSTGDEHSrgnwghldqVAALRWVQDNIASFGGNP 213
Cdd:PRK10162   83 TLFYLHGGGFILGNLDTHDRIMrlLASYSGCTVIGIDYTLSPEARFPQAIEEI---------VAVCCYFHQHAEDYGINM 153

                          90
                  ....*....|.
gi 2462490803 214 GSVTIFGESAG 224
Cdd:PRK10162  154 SRIGFAGDSAG 164
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 122-225 3.64e-04

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 42.68  E-value: 3.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 122 IYTPADLTKKNRLPVMVWIHGGGlmvGAASTYD---GL-ALAAHENVVVV----TIQYRLGIWGFFSTGDEHSRGnwGHL 193
Cdd:COG3509    41 LYVPAGYDGGAPLPLVVALHGCG---GSAADFAagtGLnALADREGFIVVypegTGRAPGRCWNWFDGRDQRRGR--DDV 115

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462490803 194 DQVAALrwVQDNIASFGGNPGSVTIFGESAGG 225
Cdd:COG3509   116 AFIAAL--VDDLAARYGIDPKRVYVTGLSAGG 145
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 120-254 6.59e-04

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 41.68  E-value: 6.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 120 LNIYTPADLTKKNRLPVMVWIHGGGL--MVGAASTYDGLALAAH-ENVVVVTIQY-----RLGIWGFfstGDEHSRGNWG 191
Cdd:pfam00756  10 VQVYLPEDYPPGRKYPVLYLLDGTGWfqNGPAKEGLDRLAASGEiPPVIIVGSPRggevsFYSDWDR---GLNATEGPGA 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462490803 192 H--LDQVAA--LRWVQDNiasFGGNPGSVTIFGESAGGesVSVLVLSPLAKNLFHRAISESGVALTS 254
Cdd:pfam00756  87 YayETFLTQelPPLLDAN---FPTAPDGRALAGQSMGG--LGALYLALKYPDLFGSVSSFSPILNPS 148
COG4099 COG4099
Predicted peptidase [General function prediction only];
94-225 9.10e-04

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 41.11  E-value: 9.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803  94 AGQLLSELFTNRKENIPLKlsedclYlNIYTPADLTKKNRLPVMVWIHGGG---------LMVGAAStYDGLALAAHENV 164
Cdd:COG4099    16 QDGFEARTFTDPSDGDTLP------Y-RLYLPKGYDPGKKYPLVLFLHGAGergtdnekqLTHGAPK-FINPENQAKFPA 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462490803 165 VVVTIQYRLGIWgffstgdehsrgnWGHLDQVAAL-RWVQDNIASFGGNPGSVTIFGESAGG 225
Cdd:COG4099    88 IVLAPQCPEDDY-------------WSDTKALDAVlALLDDLIAEYRIDPDRIYLTGLSMGG 136
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
120-249 1.62e-03

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 40.99  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462490803 120 LNIYTPADLTKKN-RLPVMVWIHGGGL-------MVGAASTYDGLAlAAHE--NVVVVTIQYRLGiwgffSTGDEHSRGN 189
Cdd:COG2382    97 VWVYLPPGYDNPGkKYPVLYLLDGGGGdeqdwfdQGRLPTILDNLI-AAGKipPMIVVMPDGGDG-----GDRGTEGPGN 170

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462490803 190 WGHLDQVAA--LRWVQDNiASFGGNPGSVTIFGESAGG-ESVSVLVLSPlakNLFHRAISESG 249
Cdd:COG2382   171 DAFERFLAEelIPFVEKN-YRVSADPEHRAIAGLSMGGlAALYAALRHP---DLFGYVGSFSG 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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