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Conserved domains on  [gi|2462491577|ref|XP_054185558|]
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putative zinc finger protein 66 isoform X1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-42 2.37e-18

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.17  E-value: 2.37e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462491577    2 AQRNLYRDVMLENYRNLVFLGIVVSKPDLITHLEQGKKPST 42
Cdd:smart00349  21 AQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-561 9.47e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 9.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 177 KPYKCIECGKAFNRSSHLTTHKIIHTGEKRYKCED--CGKAFNRSSNLTTHKKIHTGEKPYkcEECGKAFKRSSILTTHK 254
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 255 RIHTGEKPYKCEECgkVFKYLSSLSTHKIIHTGEKPYKCEECG-KAFNWSSHLTTH--KRIHTGEKPykcEECGKGFKYS 331
Cdd:COG5048   110 LSSSSSNSNDNNLL--SSHSLPPSSRDPQLPDLLSISNLRNNPlPGNNSSSVNTPQsnSLHPPLPAN---SLSKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 332 STLTKHKIIHTGEKPYKCEECGEAFKYSCSLTAHKIIH------------------------TGKKPYKCEECGKVFKHS 387
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnsqlspksllsqspsSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 388 SPLSKHKRIH----------AGEKPYKCEECGKAFSRSSILTTHK--IIHTGE--KPYEC--EDCGKAFNRSSNLTKHKK 451
Cdd:COG5048   265 LPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 452 IHTGEKPYKCEEC-------GKAFKCSSILTTHKRIHTADKPYKCE--ECGKDFKYSSTLTRHKRIHTGEKP--YKCEEC 520
Cdd:COG5048   345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 2462491577 521 GKAFNHPATLFSHKKIHTGGKPHKCNKCGKaFISSSNLSRH 561
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-42 2.37e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.17  E-value: 2.37e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462491577    2 AQRNLYRDVMLENYRNLVFLGIVVSKPDLITHLEQGKKPST 42
Cdd:smart00349  21 AQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-561 9.47e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 9.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 177 KPYKCIECGKAFNRSSHLTTHKIIHTGEKRYKCED--CGKAFNRSSNLTTHKKIHTGEKPYkcEECGKAFKRSSILTTHK 254
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 255 RIHTGEKPYKCEECgkVFKYLSSLSTHKIIHTGEKPYKCEECG-KAFNWSSHLTTH--KRIHTGEKPykcEECGKGFKYS 331
Cdd:COG5048   110 LSSSSSNSNDNNLL--SSHSLPPSSRDPQLPDLLSISNLRNNPlPGNNSSSVNTPQsnSLHPPLPAN---SLSKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 332 STLTKHKIIHTGEKPYKCEECGEAFKYSCSLTAHKIIH------------------------TGKKPYKCEECGKVFKHS 387
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnsqlspksllsqspsSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 388 SPLSKHKRIH----------AGEKPYKCEECGKAFSRSSILTTHK--IIHTGE--KPYEC--EDCGKAFNRSSNLTKHKK 451
Cdd:COG5048   265 LPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 452 IHTGEKPYKCEEC-------GKAFKCSSILTTHKRIHTADKPYKCE--ECGKDFKYSSTLTRHKRIHTGEKP--YKCEEC 520
Cdd:COG5048   345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 2462491577 521 GKAFNHPATLFSHKKIHTGGKPHKCNKCGKaFISSSNLSRH 561
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 2-22 1.35e-09

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 53.63  E-value: 1.35e-09
                          10        20
                  ....*....|....*....|.
gi 2462491577   2 AQRNLYRDVMLENYRNLVFLG 22
Cdd:pfam01352  22 AQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-21 2.28e-07

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 47.16  E-value: 2.28e-07
                          10        20
                  ....*....|....*....|
gi 2462491577   2 AQRNLYRDVMLENYRNLVFL 21
Cdd:cd07765    21 AQRDLYRDVMLENYENLVSL 40
zf-H2C2_2 pfam13465
Zinc-finger double domain;
502-526 2.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.35e-04
                          10        20
                  ....*....|....*....|....*
gi 2462491577 502 LTRHKRIHTGEKPYKCEECGKAFNH 526
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-42 2.37e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.17  E-value: 2.37e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462491577    2 AQRNLYRDVMLENYRNLVFLGIVVSKPDLITHLEQGKKPST 42
Cdd:smart00349  21 AQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-561 9.47e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 76.66  E-value: 9.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 177 KPYKCIECGKAFNRSSHLTTHKIIHTGEKRYKCED--CGKAFNRSSNLTTHKKIHTGEKPYkcEECGKAFKRSSILTTHK 254
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 255 RIHTGEKPYKCEECgkVFKYLSSLSTHKIIHTGEKPYKCEECG-KAFNWSSHLTTH--KRIHTGEKPykcEECGKGFKYS 331
Cdd:COG5048   110 LSSSSSNSNDNNLL--SSHSLPPSSRDPQLPDLLSISNLRNNPlPGNNSSSVNTPQsnSLHPPLPAN---SLSKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 332 STLTKHKIIHTGEKPYKCEECGEAFKYSCSLTAHKIIH------------------------TGKKPYKCEECGKVFKHS 387
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnsqlspksllsqspsSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 388 SPLSKHKRIH----------AGEKPYKCEECGKAFSRSSILTTHK--IIHTGE--KPYEC--EDCGKAFNRSSNLTKHKK 451
Cdd:COG5048   265 LPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 452 IHTGEKPYKCEEC-------GKAFKCSSILTTHKRIHTADKPYKCE--ECGKDFKYSSTLTRHKRIHTGEKP--YKCEEC 520
Cdd:COG5048   345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 2462491577 521 GKAFNHPATLFSHKKIHTGGKPHKCNKCGKaFISSSNLSRH 561
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
218-575 3.43e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 3.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 218 RSSNLTTHKKIHTGEKPYKCEECGKAFKRSSILTTHKRIHTGEKPYKC--EECGKVFKYLSSLSTHKIIHTGEKPYKCE- 294
Cdd:COG5048    17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSk 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 295 ECGKAFNWSSHLTTHKRIHTGEKPYKCEECGKGFKYSSTLTK--HKIIHTGEKPYK---------------------CEE 351
Cdd:COG5048    97 SLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgnnsssvntpqsnslhpplpaNSL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 352 CGEAFKYSCSLTAHKIIHTGKKPYKCEECGKVFKHSSPLSKHKRIHAgEKPYKCEECGKAF-------SRSSILTTHKII 424
Cdd:COG5048   177 SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSpksllsqSPSSLSSSDSSS 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 425 HTGEkPYECEDCGKAFNRSSNLTKHKKIHTG-EKPYKCEECGKAFKCSSILTTHKR--IHT--ADKPYKCEE--CGKDFK 497
Cdd:COG5048   256 SASE-SPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSgeSLKPFSCPYslCGKLFS 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 498 YSSTLTRHKRIHTGEKPYKC--EECGKAFNHPAT-----LFSHKKIHTGGKPHKC--NKCGKAFISSSNLSRHEIIHMGG 568
Cdd:COG5048   335 RNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSF 414


                  ....*..
gi 2462491577 569 NPYKCEN 575
Cdd:COG5048   415 RPYNCKN 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
123-478 9.17e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 9.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 123 FQCDKHGKVFHQFSNTNRHKIRHTGKNPF--KFTECGKAFNRSSTLTTHKKIHTGEKPYKC----------------IEC 184
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSqcSYSGCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 185 GKAFNR----SSHLTTHKIIHT-----------------GEKRYKCED---------------CGKAFNRSSNLTTHKKI 228
Cdd:COG5048   114 SSNSNDnnllSSHSLPPSSRDPqlpdllsisnlrnnplpGNNSSSVNTpqsnslhpplpanslSKDPSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 229 HTGEKPYKCEECGKAFKRSSILTTHKRIHTgEKPYKCEECGKVFK-------YLSSLSTHKIIHTGEKPYKCEeCGKAFN 301
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPksllsqsPSSLSSSDSSSSASESPRSSL-PTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 302 WSSHLTTHKRIHTG-EKPYKCEECGKGFKYSSTLTKHK--IIHTGE--KPYKCEE--CGEAFKYSCSLTAHKIIHTGKKP 374
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 375 YKC--EECGKVF------KHSSPLSKHKRIHAGEKPYKCE-ECGKAFSRSSILTTHKIIHTGEKPYECED--CGKAFNRS 443
Cdd:COG5048   352 AKEklLNSSSKFspllnnEPPQSLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 2462491577 444 SNLTKHKKIHTGEKPYKCEECGKAFKCSSILTTHK 478
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 2-22 1.35e-09

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 53.63  E-value: 1.35e-09
                          10        20
                  ....*....|....*....|.
gi 2462491577   2 AQRNLYRDVMLENYRNLVFLG 22
Cdd:pfam01352  22 AQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-21 2.28e-07

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 47.16  E-value: 2.28e-07
                          10        20
                  ....*....|....*....|
gi 2462491577   2 AQRNLYRDVMLENYRNLVFL 21
Cdd:cd07765    21 AQRDLYRDVMLENYENLVSL 40
zf-H2C2_2 pfam13465
Zinc-finger double domain;
502-526 2.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.35e-04
                          10        20
                  ....*....|....*....|....*
gi 2462491577 502 LTRHKRIHTGEKPYKCEECGKAFNH 526
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
445-470 2.56e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.56e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462491577 445 NLTKHKKIHTGEKPYKCEECGKAFKC 470
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 315-394 2.60e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 315 GEKPYKCE--ECGKGFKYSSTLTKHKIiHTGEKPYKCEECGEafkyscslTAHKIIHTGKKPYKCEECGKVFKHSSPLSK 392
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462491577 393 HK 394
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
221-246 3.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.79e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462491577 221 NLTTHKKIHTGEKPYKCEECGKAFKR 246
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 231-282 6.42e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 6.42e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462491577 231 GEKPYKCE--ECGKAFKRSSILTTHKR-------------------IHTGEKPYKCEECGKVFKYLSSLSTHK 282
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 387-506 7.64e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 7.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 387 SSPLSKHKRIHAGEKPYKCEECGKAFSRSSILT----THKIIHTGEKPYECE--DCGKAFNRSSNLTKHKKihTGEKPYK 460
Cdd:COG5189   302 RGGISTGEMIDVRKLPCTNSSSNGKLAHGGERNidtpSRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHML--HGHQNQK 379

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2462491577 461 CEECGKAFKcssilttHKRIHTADKPYKCEECGKDFKYSSTLTRHK 506
Cdd:COG5189   380 LHENPSPEK-------MNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
305-330 8.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.00e-04
                          10        20
                  ....*....|....*....|....*.
gi 2462491577 305 HLTTHKRIHTGEKPYKCEECGKGFKY 330
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
250-274 1.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.40e-03
                          10        20
                  ....*....|....*....|....*
gi 2462491577 250 LTTHKRIHTGEKPYKCEECGKVFKY 274
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
166-190 1.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.46e-03
                          10        20
                  ....*....|....*....|....*
gi 2462491577 166 LTTHKKIHTGEKPYKCIECGKAFNR 190
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 371-451 1.66e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 371 GKKPYKCE--ECGKVFKHSSPLsKHKRIHAGEKPYKCEECGKafsrssilTTHKIIHTGEKPYECEDCGKAFNRSSNLTK 448
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 2462491577 449 HKK 451
Cdd:COG5189   417 HRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
120-254 2.27e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 120 SKMFQCDKH--GKVFHQFSNTNRHKIRHTGKNPFK--FTECGKAFNRSST-----LTTHKKIHTGEKPYKCI--ECGKAF 188
Cdd:COG5048   319 LKPFSCPYSlcGKLFSRNDALKRHILLHTSISPAKekLLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNF 398

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462491577 189 NRSSHLTTHKIIHT--GEKRYKCEDCGKAFNRSSNLTTHKKIHTGEKPYKCEECGKAFKRSSILTTHK 254
Cdd:COG5048   399 KRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 455-535 3.58e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 455 GEKPYKCE--ECGKAFKCSSILTTHkRIHTADKPYKCEECGKDfkysstltRHKRIHTGEKPYKCEECGKAFNHPATLFS 532
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 2462491577 533 HKK 535
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
390-414 3.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.78e-03
                          10        20
                  ....*....|....*....|....*
gi 2462491577 390 LSKHKRIHAGEKPYKCEECGKAFSR 414
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
277-301 4.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.60e-03
                          10        20
                  ....*....|....*....|....*
gi 2462491577 277 SLSTHKIIHTGEKPYKCEECGKAFN 301
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
334-358 4.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.78e-03
                          10        20
                  ....*....|....*....|....*
gi 2462491577 334 LTKHKIIHTGEKPYKCEECGEAFKY 358
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 287-366 5.03e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 5.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462491577 287 GEKPYKCE--ECGKAFNWSSHLTTHKrihtgekpyKCEECGKGFKYSSTLTKHKIIHTGEKPYKCEECGEAFKYSCSLTA 364
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2462491577 365 HK 366
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
474-498 8.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.05e-03
                          10        20
                  ....*....|....*....|....*
gi 2462491577 474 LTTHKRIHTADKPYKCEECGKDFKY 498
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
418-442 9.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.61e-03
                          10        20
                  ....*....|....*....|....*
gi 2462491577 418 LTTHKIIHTGEKPYECEDCGKAFNR 442
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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