NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462493867|ref|XP_054186508|]
View 

putative hydrolase DDAH2 isoform X1 [Homo sapiens]

Protein Classification

dimethylarginine dimethylaminohydrolase family protein( domain architecture ID 1904273)

dimethylarginine dimethylaminohydrolase (DdaH) family protein similar to Pseudomonas aeruginosa N(G),N(G)-dimethylarginine dimethylaminohydrolase that hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DdaH super family cl43535
N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];
63-172 1.93e-11

N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];


The actual alignment was detected with superfamily member COG1834:

Pssm-ID: 441439 [Multi-domain]  Cd Length: 264  Bit Score: 62.89  E-value: 1.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462493867  63 LPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEIgDENATLDGTDVLFTGREFFVGLSK 142
Cdd:COG1834    56 LPPVPGLPDMVFTRDAGLVIGDGAILARMRHPERRGEEAAYREWLEELGIPVVRL-PEPGVFEGGDVLLDGDTLLVGYGF 134

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462493867 143 WTNHRGAEIVADTFrDFAVSTVPVSGPS--HL 172
Cdd:COG1834   135 RTNRAGIEWLARLL-GYEVVPLELVDPRflHL 165
 
Name Accession Description Interval E-value
DdaH COG1834
N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];
63-172 1.93e-11

N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];


Pssm-ID: 441439 [Multi-domain]  Cd Length: 264  Bit Score: 62.89  E-value: 1.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462493867  63 LPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEIgDENATLDGTDVLFTGREFFVGLSK 142
Cdd:COG1834    56 LPPVPGLPDMVFTRDAGLVIGDGAILARMRHPERRGEEAAYREWLEELGIPVVRL-PEPGVFEGGDVLLDGDTLLVGYGF 134

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462493867 143 WTNHRGAEIVADTFrDFAVSTVPVSGPS--HL 172
Cdd:COG1834   135 RTNRAGIEWLARLL-GYEVVPLELVDPRflHL 165
 
Name Accession Description Interval E-value
DdaH COG1834
N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];
63-172 1.93e-11

N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];


Pssm-ID: 441439 [Multi-domain]  Cd Length: 264  Bit Score: 62.89  E-value: 1.93e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462493867  63 LPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEIgDENATLDGTDVLFTGREFFVGLSK 142
Cdd:COG1834    56 LPPVPGLPDMVFTRDAGLVIGDGAILARMRHPERRGEEAAYREWLEELGIPVVRL-PEPGVFEGGDVLLDGDTLLVGYGF 134

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462493867 143 WTNHRGAEIVADTFrDFAVSTVPVSGPS--HL 172
Cdd:COG1834   135 RTNRAGIEWLARLL-GYEVVPLELVDPRflHL 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH