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Conserved domains on  [gi|2462493891|ref|XP_054186519|]
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natural cytotoxicity triggering receptor 3 isoform X2 [Homo sapiens]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 18-104 6.17e-57

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd20926:

Pssm-ID: 472250  Cd Length: 112  Bit Score: 174.39  E-value: 6.17e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462493891  18 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVVPGKE-------------------------AELHIRD 72
Cdd:cd20926     1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEvrngtpefrgrlaplassrflrdhqAELHIWD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462493891  73 VRGHDASIYVCRVEVLGLGVGTGNGTRLVVEK 104
Cdd:cd20926    81 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
 
Name Accession Description Interval E-value
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 18-104 6.17e-57

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 174.39  E-value: 6.17e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462493891  18 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVVPGKE-------------------------AELHIRD 72
Cdd:cd20926     1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEvrngtpefrgrlaplassrflrdhqAELHIWD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462493891  73 VRGHDASIYVCRVEVLGLGVGTGNGTRLVVEK 104
Cdd:cd20926    81 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
I-set pfam07679
Immunoglobulin I-set domain;
21-86 1.12e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 41.86  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462493891  21 VSQPPEIRTLEGSSAFLPCSfnasqgrlAIG----SVTWFRDE-----------VVPGKEAELHIRDVRGHDASIYVCRV 85
Cdd:pfam07679   4 TQKPKDVEVQEGESARFTCT--------VTGtpdpEVSWFKDGqplrssdrfkvTYEGGTYTLTISNVQPDDSGKYTCVA 75


                  .
gi 2462493891  86 E 86
Cdd:pfam07679  76 T 76
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 24-102 1.14e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 1.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462493891   24 PPEIRTLEGSSAFLPCSFNASqgrlAIGSVTWFRDEVVP------------GKEAELHIRDVRGHDASIYVCRVEVlGLG 91
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGS----PPPEVTWYKQGGKLlaesgrfsvsrsGSTSTLTISNVTPEDSGTYTCAATN-SSG 75

                           90
                   ....*....|.
gi 2462493891   92 VGTGnGTRLVV 102
Cdd:smart00410  76 SASS-GTTLTV 85
 
Name Accession Description Interval E-value
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 18-104 6.17e-57

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 174.39  E-value: 6.17e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462493891  18 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVVPGKE-------------------------AELHIRD 72
Cdd:cd20926     1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEvrngtpefrgrlaplassrflrdhqAELHIWD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462493891  73 VRGHDASIYVCRVEVLGLGVGTGNGTRLVVEK 104
Cdd:cd20926    81 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
I-set pfam07679
Immunoglobulin I-set domain;
21-86 1.12e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 41.86  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462493891  21 VSQPPEIRTLEGSSAFLPCSfnasqgrlAIG----SVTWFRDE-----------VVPGKEAELHIRDVRGHDASIYVCRV 85
Cdd:pfam07679   4 TQKPKDVEVQEGESARFTCT--------VTGtpdpEVSWFKDGqplrssdrfkvTYEGGTYTLTISNVQPDDSGKYTCVA 75


                  .
gi 2462493891  86 E 86
Cdd:pfam07679  76 T 76
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 24-102 1.14e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 1.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462493891   24 PPEIRTLEGSSAFLPCSFNASqgrlAIGSVTWFRDEVVP------------GKEAELHIRDVRGHDASIYVCRVEVlGLG 91
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGS----PPPEVTWYKQGGKLlaesgrfsvsrsGSTSTLTISNVTPEDSGTYTCAATN-SSG 75

                           90
                   ....*....|.
gi 2462493891   92 VGTGnGTRLVV 102
Cdd:smart00410  76 SASS-GTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 21-86 2.57e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 37.93  E-value: 2.57e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462493891  21 VSQPPEIRTLEGSSAFLPCSFNASQGRlaigSVTWFRDEVVP-----------GKEAELHIRDVRGHDASIYVCRVE 86
Cdd:pfam13927   5 TVSPSSVTVREGETVTLTCEATGSPPP----TITWYKNGEPIssgstrsrslsGSNSTLTISNVTRSDAGTYTCVAS 77
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 35-86 1.22e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.15  E-value: 1.22e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462493891  35 AFLPCSFNASQGrlaiGSVTWFRDE-----------VVPGKEAELHIRDVRGHDASIYVCRVE 86
Cdd:cd00096     1 VTLTCSASGNPP----PTITWYKNGkplppssrdsrRSELGNGTLTISNVTLEDSGTYTCVAS 59
IgI_1_MuSK cd20970
agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of ...
 21-84 1.99e-03

agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains; The members here are composed of the first immunoglobulin-like domains (Ig1) of the Muscle-specific kinase (MuSK). MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409562 [Multi-domain]  Cd Length: 92  Bit Score: 35.95  E-value: 1.99e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462493891  21 VSQPPEIRT-LEGSSAFLPCsfnasqgrLAIGS----VTWFRDEVVPGKEAE----------LHIRDVRGHDASIYVCR 84
Cdd:cd20970     5 TPQPSFTVTaREGENATFMC--------RAEGSpepeISWTRNGNLIIEFNTryivrengttLTIRNIRRSDMGIYLCI 75
Ig_2 pfam13895
Immunoglobulin domain; This domain contains immunoglobulin-like domains.
 21-102 4.91e-03

Immunoglobulin domain; This domain contains immunoglobulin-like domains.


Pssm-ID: 464026 [Multi-domain]  Cd Length: 79  Bit Score: 34.68  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462493891  21 VSQPPEIRTLEGSSAFLPCSFNASQGrlaiGSVTWFRDEVVPGKEAELHIRDVRGHDASIYVCRVEvLGLGVGTGNGTRL 100
Cdd:pfam13895   3 VLTPSPTVVTEGEPVTLTCSAPGNPP----PSYTWYKDGSAISSSPNFFTLSVSAEDSGTYTCVAR-NGRGGKVSNPVEL 77


                  ..
gi 2462493891 101 VV 102
Cdd:pfam13895  78 TV 79
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 24-85 5.63e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 34.48  E-value: 5.63e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462493891  24 PPEIRTLEGSSAFLPCSfnASQGRLAIgSVTWFR--------DEVVPGKE----AELHIRDVRGHDASIYVCRV 85
Cdd:pfam00047   3 PPTVTVLEGDSATLTCS--ASTGSPGP-DVTWSKeggtliesLKVKHDNGrttqSSLLISNVTKEDAGTYTCVV 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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