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Conserved domains on  [gi|2462494051|ref|XP_054186598|]
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transcription factor 19 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FHA_TCF19 cd22685
forkhead associated (FHA) domain found in transcription factor 19 (TCF-19) and similar ...
 3-123 1.54e-51

forkhead associated (FHA) domain found in transcription factor 19 (TCF-19) and similar proteins; TCF-19, also called transcription factor SC1, was identified as a putative trans-activating factor with expression beginning at the late G1-S boundary in dividing cells. It also functions as a novel islet factor necessary for proliferation and survival in the INS-1 beta cell line. It plays an important role in susceptibility to both Type 1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM); it has been suggested that it may positively impact beta cell mass under conditions of beta cell stress and increased insulin demand. TCF-19 contains an N-terminal fork head association domain (FHA), a proline rich region, and a C-terminal plant homeodomain (PHD) finger. The FHA domain may serve as a nuclear signaling domain or as a phosphoprotein binding domain. The proline rich region is a common characteristic of trans-activating factors. The PHD finger may allow TCF-19 to interact with chromatin via methylated histone H3.


:

Pssm-ID: 438737 [Multi-domain]  Cd Length: 130  Bit Score: 162.20  E-value: 1.54e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494051   3 PCFQLLRI----GGGRGGDLYTFHPPAgagCTYRLGHRADLCDVALRPQQEPGLISGIHAELHAEPRG-DDWRVSLEDHS 77
Cdd:cd22685     1 PCFQLLRIglsaSRSEPRDLYTFRPDL---CEYRIGRNPEVCDVFLCSSQHPNLISREHAEIHAERDGnGNWKVLIEDRS 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462494051  78 SQGTLVNNVRLPRGHRLELSDGDLLTFGPEGP------PGTSPSEFYFMFQQ 123
Cdd:cd22685    78 TNGTYVNDVRLQDGQRRELSDGDTITFGHKNGrrvkqwPYQKSSEFYFLFQK 129
 
Name Accession Description Interval E-value
FHA_TCF19 cd22685
forkhead associated (FHA) domain found in transcription factor 19 (TCF-19) and similar ...
 3-123 1.54e-51

forkhead associated (FHA) domain found in transcription factor 19 (TCF-19) and similar proteins; TCF-19, also called transcription factor SC1, was identified as a putative trans-activating factor with expression beginning at the late G1-S boundary in dividing cells. It also functions as a novel islet factor necessary for proliferation and survival in the INS-1 beta cell line. It plays an important role in susceptibility to both Type 1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM); it has been suggested that it may positively impact beta cell mass under conditions of beta cell stress and increased insulin demand. TCF-19 contains an N-terminal fork head association domain (FHA), a proline rich region, and a C-terminal plant homeodomain (PHD) finger. The FHA domain may serve as a nuclear signaling domain or as a phosphoprotein binding domain. The proline rich region is a common characteristic of trans-activating factors. The PHD finger may allow TCF-19 to interact with chromatin via methylated histone H3.


Pssm-ID: 438737 [Multi-domain]  Cd Length: 130  Bit Score: 162.20  E-value: 1.54e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494051   3 PCFQLLRI----GGGRGGDLYTFHPPAgagCTYRLGHRADLCDVALRPQQEPGLISGIHAELHAEPRG-DDWRVSLEDHS 77
Cdd:cd22685     1 PCFQLLRIglsaSRSEPRDLYTFRPDL---CEYRIGRNPEVCDVFLCSSQHPNLISREHAEIHAERDGnGNWKVLIEDRS 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462494051  78 SQGTLVNNVRLPRGHRLELSDGDLLTFGPEGP------PGTSPSEFYFMFQQ 123
Cdd:cd22685    78 TNGTYVNDVRLQDGQRRELSDGDTITFGHKNGrrvkqwPYQKSSEFYFLFQK 129
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
30-106 2.93e-09

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 52.27  E-value: 2.93e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462494051  30 TYRLGhRADLCDVALrpqqEPGLISGIHAELhaEPRGDDWRVslED-HSSQGTLVNNVRLPRGHRleLSDGDLLTFGP 106
Cdd:COG1716    22 PLTIG-RAPDNDIVL----DDPTVSRRHARI--RRDGGGWVL--EDlGSTNGTFVNGQRVTEPAP--LRDGDVIRLGK 88
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 31-104 1.19e-08

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 49.88  E-value: 1.19e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462494051  31 YRLGhRADLCDVALRPQQepglISGIHAELHaepRGDDWRVSLEDH-SSQGTLVNNVRLPRgHRLELSDGDLLTF 104
Cdd:pfam00498   1 VTIG-RSPDCDIVLDDPS----VSRRHAEIR---YDGGGRFYLEDLgSTNGTFVNGQRLGP-EPVRLKDGDVIRL 66
VI_FHA TIGR03354
type VI secretion system FHA domain protein; Members of this protein family are FHA ...
 26-106 5.77e-08

type VI secretion system FHA domain protein; Members of this protein family are FHA (forkhead-associated) domain-containing proteins that are part of type VI secretion loci in a considerable number of bacteria, most of which are known pathogens. Species include Pseudomonas aeruginosa PAO1, Aeromonas hydrophila, Yersinia pestis, Burkholderia mallei, etc. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274537 [Multi-domain]  Cd Length: 396  Bit Score: 51.60  E-value: 5.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494051  26 GAGCTYRLGH------RADLCDVALRPQQepGLISGIHAELhaepRGDDWRVSLEDHSSQGTLVNN--VRLPRGHRLELS 97
Cdd:TIGR03354  14 GIAAQKTFGTnggtigRSEDCDWVLPDPE--RHVSGRHARI----RYRDGAYLLTDLSTNGVFLNGsgSPLGRGNPVRLE 87


                  ....*....
gi 2462494051  98 DGDLLTFGP 106
Cdd:TIGR03354  88 QGDRLRLGD 96
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 31-88 6.95e-05

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 39.08  E-value: 6.95e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462494051   31 YRLGHRADLCDVALRPQQepglISGIHAELHAEPRGddwRVSLEDHSS-QGTLVNNVRL 88
Cdd:smart00240   1 VTIGRSSEDCDIQLDGPS----ISRRHAVIVYDGGG---RFYLIDLGStNGTFVNGKRI 52
 
Name Accession Description Interval E-value
FHA_TCF19 cd22685
forkhead associated (FHA) domain found in transcription factor 19 (TCF-19) and similar ...
 3-123 1.54e-51

forkhead associated (FHA) domain found in transcription factor 19 (TCF-19) and similar proteins; TCF-19, also called transcription factor SC1, was identified as a putative trans-activating factor with expression beginning at the late G1-S boundary in dividing cells. It also functions as a novel islet factor necessary for proliferation and survival in the INS-1 beta cell line. It plays an important role in susceptibility to both Type 1 Diabetes Mellitus (T1DM) and Type 2 Diabetes Mellitus (T2DM); it has been suggested that it may positively impact beta cell mass under conditions of beta cell stress and increased insulin demand. TCF-19 contains an N-terminal fork head association domain (FHA), a proline rich region, and a C-terminal plant homeodomain (PHD) finger. The FHA domain may serve as a nuclear signaling domain or as a phosphoprotein binding domain. The proline rich region is a common characteristic of trans-activating factors. The PHD finger may allow TCF-19 to interact with chromatin via methylated histone H3.


Pssm-ID: 438737 [Multi-domain]  Cd Length: 130  Bit Score: 162.20  E-value: 1.54e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494051   3 PCFQLLRI----GGGRGGDLYTFHPPAgagCTYRLGHRADLCDVALRPQQEPGLISGIHAELHAEPRG-DDWRVSLEDHS 77
Cdd:cd22685     1 PCFQLLRIglsaSRSEPRDLYTFRPDL---CEYRIGRNPEVCDVFLCSSQHPNLISREHAEIHAERDGnGNWKVLIEDRS 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462494051  78 SQGTLVNNVRLPRGHRLELSDGDLLTFGPEGP------PGTSPSEFYFMFQQ 123
Cdd:cd22685    78 TNGTYVNDVRLQDGQRRELSDGDTITFGHKNGrrvkqwPYQKSSEFYFLFQK 129
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 30-106 2.18e-09

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 52.28  E-value: 2.18e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462494051  30 TYRLGhRADLCDVALRPQQepglISGIHAELHAeprgDDWRVSLEDHSSQ-GTLVNNVRLPRGHRLElsDGDLLTFGP 106
Cdd:cd00060    20 VVTIG-RSPDCDIVLDDPS----VSRRHARIEV----DGGGVYLEDLGSTnGTFVNGKRITPPVPLQ--DGDVIRLGD 86
FHA_NBN cd22667
forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also ...
 18-105 2.56e-09

forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also called cell cycle regulatory protein p95, or Nijmegen breakage syndrome protein 1 (NBS1), is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. Nibrin modulates the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. Nibrin also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. Nibrin is a major player in the control of intra-S-phase checkpoint. This subfamily also includes Schizosaccharomyces pombe DNA repair and telomere maintenance protein Nbs1 and Arabidopsis thaliana AtNbs1. SpNbs1 is an FHA domain-containing protein required for DNA damage repair and S-phase DNA damage checkpoint. It is involved in telomere length maintenance and maintenance of chromatin structure. AtNbs1 is a component of MRN complex. It also functions in the very early stages of meiosis. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438719 [Multi-domain]  Cd Length: 108  Bit Score: 52.71  E-value: 2.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494051  18 LYTFHPPAG------AGCTYRLGhRADlCDVALRPQQEpglISGIHAEL---HAEPRGDDW----RVSLEDHSSQGTLVN 84
Cdd:cd22667     3 LLSEQDGAGtsyyllPGGEYTVG-RKD-CDIIIVDDSS---ISRKHATLtvlHPEANLSDPdtrpELTLKDLSKYGTFVN 77

                          90       100
                  ....*....|....*....|.
gi 2462494051  85 NVRLPRGHRLELSDGDLLTFG 105
Cdd:cd22667    78 GEKLKGGSEVTLKDGDVITFG 98
FHA COG1716
Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];
30-106 2.93e-09

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];


Pssm-ID: 441322 [Multi-domain]  Cd Length: 96  Bit Score: 52.27  E-value: 2.93e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462494051  30 TYRLGhRADLCDVALrpqqEPGLISGIHAELhaEPRGDDWRVslED-HSSQGTLVNNVRLPRGHRleLSDGDLLTFGP 106
Cdd:COG1716    22 PLTIG-RAPDNDIVL----DDPTVSRRHARI--RRDGGGWVL--EDlGSTNGTFVNGQRVTEPAP--LRDGDVIRLGK 88
COG3456 COG3456
Predicted component of the type VI protein secretion system, contains a FHA domain [Signal ...
 19-106 3.07e-09

Predicted component of the type VI protein secretion system, contains a FHA domain [Signal transduction mechanisms, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442679 [Multi-domain]  Cd Length: 402  Bit Score: 55.54  E-value: 3.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494051  19 YTFHPPAGagctyRLGhRADLCDVALRPQQepGLISGIHAELhaepRGDDWRVSLEDHSSQGTLVNN--VRLPRGHRLEL 96
Cdd:COG3456    21 ATFGRGGG-----TIG-RSADCDWVLPDPD--RSVSRRHAEI----RFRDGAFCLTDLSTNGTFLNGsdHPLGPGRPVRL 88

                          90
                  ....*....|
gi 2462494051  97 SDGDLLTFGP 106
Cdd:COG3456    89 RDGDRLRIGD 98
FHA pfam00498
FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.
 31-104 1.19e-08

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.


Pssm-ID: 459831 [Multi-domain]  Cd Length: 66  Bit Score: 49.88  E-value: 1.19e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462494051  31 YRLGhRADLCDVALRPQQepglISGIHAELHaepRGDDWRVSLEDH-SSQGTLVNNVRLPRgHRLELSDGDLLTF 104
Cdd:pfam00498   1 VTIG-RSPDCDIVLDDPS----VSRRHAEIR---YDGGGRFYLEDLgSTNGTFVNGQRLGP-EPVRLKDGDVIRL 66
VI_FHA TIGR03354
type VI secretion system FHA domain protein; Members of this protein family are FHA ...
 26-106 5.77e-08

type VI secretion system FHA domain protein; Members of this protein family are FHA (forkhead-associated) domain-containing proteins that are part of type VI secretion loci in a considerable number of bacteria, most of which are known pathogens. Species include Pseudomonas aeruginosa PAO1, Aeromonas hydrophila, Yersinia pestis, Burkholderia mallei, etc. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274537 [Multi-domain]  Cd Length: 396  Bit Score: 51.60  E-value: 5.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494051  26 GAGCTYRLGH------RADLCDVALRPQQepGLISGIHAELhaepRGDDWRVSLEDHSSQGTLVNN--VRLPRGHRLELS 97
Cdd:TIGR03354  14 GIAAQKTFGTnggtigRSEDCDWVLPDPE--RHVSGRHARI----RYRDGAYLLTDLSTNGVFLNGsgSPLGRGNPVRLE 87


                  ....*....
gi 2462494051  98 DGDLLTFGP 106
Cdd:TIGR03354  88 QGDRLRLGD 96
FHA_CHFR cd22672
forkhead associated (FHA) domain found in checkpoint with forkhead and RING finger domains ...
 36-104 6.82e-08

forkhead associated (FHA) domain found in checkpoint with forkhead and RING finger domains protein (CHFR); CHFR, also called RING finger protein 196 (RNF196), is a checkpoint protein that delays entry into mitosis in response to stress. It functions as an E3 ubiquitin ligase that ubiquitinates and degrades its target proteins, such as Aurora-A, Plk1, Kif22 and PARP-1, which are critical for proper mitotic transitions. It also plays an important role in cell cycle progression and tumor suppression and is negatively regulated by SUMOylation-mediated proteasomal ubiquitylation. Moreover, CHFR is involved in the early stage of the DNA damage response, which mediates the crosstalk between ubiquitination and poly-ADP-ribosylation. CHFR contains a fork head associated-(FHA) domain and a RING-HC finger. The CHFR FHA domain has been crystallized as a segment-swapped dimer. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438724 [Multi-domain]  Cd Length: 108  Bit Score: 48.83  E-value: 6.82e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462494051  36 RADLCDVALrpqqePG--LISGIHAELHAEPRGddwRVSLEDHSSQGTLVNNVRLPRGHRLELSDGDLLTF 104
Cdd:cd22672    27 RAKDCDLSF-----PGnkLVSGDHCKIIRDEKG---QVWLEDTSTNGTLVNKVKVVKGQKVELKHGDVIYL 89
FHA_MEK1-like cd22670
forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine ...
 31-123 4.27e-07

forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine/threonine-protein kinase MEK1 and similar proteins; MEK1 (EC 2.7.11.1), also known as MRE4, is a meiosis-specific protein kinase required for chromosome synapsis and meiotic recombination. The recruitment and activation of MEK1 require the phosphorylation of the chromosome axis protein Hop1 at Thr318 (pT318), which is necessary for recognition by the MEK1 FHA domain. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438722 [Multi-domain]  Cd Length: 105  Bit Score: 46.45  E-value: 4.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494051  31 YRLGhRADLCDVALrpqQEPgLISGIHAELHA---EPRGDDwRVSLEDHSSQGTLVNNVRLPRGHRLELSDGDLLTFgpe 107
Cdd:cd22670    24 ITIG-RSPSCDIVI---NDP-FVSRTHCRIYSvqfDESSAP-LVYVEDLSSNGTYLNGKLIGRNNTVLLSDGDVIEI--- 94

                          90
                  ....*....|....*.
gi 2462494051 108 gppgtsPSEFYFMFQQ 123
Cdd:cd22670    95 ------AHSATFVYVH 104
FHA_RAD53-like_rpt2 cd22690
second forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine ...
 36-122 5.89e-07

second forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins; RAD53, also called CHEK2 homolog, or serine-protein kinase 1 (Spk1), is a nuclear protein kinase that phosphorylates proteins on serine, threonine, and tyrosine. It controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints and prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. It may be involved in the phosphorylation of RPH1. RAD53 contains two FHA domains. This model corresponds to the second one. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438742 [Multi-domain]  Cd Length: 105  Bit Score: 46.13  E-value: 5.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494051  36 RADLCDVALRPQQepglISGIHAELHAEPRGDD-WRVSLEDHSSQGTLVNNVRLPRGHRLELSDGDLLTFGPEGPpgtsP 114
Cdd:cd22690    25 RSKDCDEEITDPR----ISKHHCIITRKRSGKGlDDVYVTDTSTNGTFINNNRLGKGSQSLLQDGDEIVLIWDKN----N 96


                  ....*....
gi 2462494051 115 SEFY-FMFQ 122
Cdd:cd22690    97 KEKIgFIFQ 105
FHA_RAD53-like_rpt1 cd22689
first forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine ...
 31-115 1.25e-06

first forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins; RAD53, also called CHEK2 homolog, or serine-protein kinase 1 (Spk1), is a nuclear protein kinase that phosphorylates proteins on serine, threonine, and tyrosine. It controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints and prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. It may be involved in the phosphorylation of RPH1. RAD53 contains two FHA domains. This model corresponds to the first one. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438741 [Multi-domain]  Cd Length: 132  Bit Score: 46.11  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494051  31 YRLGhRADLCDVALRPQQepglISGIHAE-LHAEPRGDDWRVSLEDHSSQGTLVNNVRLPRGHRLELSDGDLLTFGpEGP 109
Cdd:cd22689    47 WTFG-RHPACDYHLGNSR----LSNKHFQiLLGESDPSDGNVLLNDISSNGTWLNGQRLEKNSNQLLSQGDEITIG-VGV 120


                  ....*.
gi 2462494051 110 PGTSPS 115
Cdd:cd22689   121 TGDILS 126
FHA_CHK2 cd22666
forkhead associated (FHA) domain found in checkpoint kinase 2 (Chk2) and similar proteins; ...
 31-100 1.42e-05

forkhead associated (FHA) domain found in checkpoint kinase 2 (Chk2) and similar proteins; Chk2, also called Hucds1, Cds1 homolog, or serine/threonine-protein kinase Chk2, plays an important role in cellular responses to DNA double-strand breaks and related lesions. It is phosphorylated and activated by ATM kinase, resulting in its dissociation from sites of damage to phosphorylate downstream targets such as BRCA1, p53, cell cycle transcription factor E2F1, the promyelocytic leukemia protein (PML) involved in apoptosis, and CDC25 phosphatases, among others. Mutations in Chk2 is linked to a variety of cancers including familial breast cancer, myelodysplastic syndromes, prostate cancer, lung cancer, and osteosarcomas. Chk2 contains an N-terminal SQ/TQ cluster domain (SCD), a central forkhead-associated (FHA) domain, and a C-terminal catalytic kinase domain. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438718 [Multi-domain]  Cd Length: 112  Bit Score: 42.61  E-value: 1.42e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462494051  31 YRLGhRADLCD-----VALRPQQEPGLISGIHAELHAEPRGDD-WRVSLEDHSSQGTLVNNVRLPRGHRLELSDGD 100
Cdd:cd22666    21 YTFG-RDKSCDycfdsPALKKTSYYRTYSKKHFRIFREKGSKNtYPVFLEDHSSNGTFVNGEKIGKGKKRPLNNND 95
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 31-88 6.95e-05

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 39.08  E-value: 6.95e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462494051   31 YRLGHRADLCDVALRPQQepglISGIHAELHAEPRGddwRVSLEDHSS-QGTLVNNVRL 88
Cdd:smart00240   1 VTIGRSSEDCDIQLDGPS----ISRRHAVIVYDGGG---RFYLIDLGStNGTFVNGKRI 52
FHA_SLMAP cd22679
forkhead associated (FHA) domain found in sarcolemmal membrane-associated protein (SLMAP) and ...
 57-105 7.97e-05

forkhead associated (FHA) domain found in sarcolemmal membrane-associated protein (SLMAP) and similar proteins; SLMAP, also called sarcolemmal-associated protein (SLAP), is a tail-anchored protein involved in fundamental cellular processes, such as myoblast fusion, cell cycle progression, and chromosomal inheritance. It is a cardiac membrane protein that plays an important role in E-C coupling and the adrenergic response of the heart. Overexpression of the SLMAP gene has been associated with diabetes and endothelial dysfunction of macro- and micro-blood vessels. SLMAP contains an N-terminal FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438731 [Multi-domain]  Cd Length: 126  Bit Score: 40.71  E-value: 7.97e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462494051  57 HAELHAEPrGDDWrvsLED-HSSQGTLVNNVRLPRGHRL----ELSDGDLLTFG 105
Cdd:cd22679    53 HALLWYDD-GKFY---LQDtKSSNGTFVNNQRLSKGSEEseprELHSGDIVQFG 102
FHA_MDC1 cd22665
forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) ...
 36-105 5.85e-04

forkhead associated (FHA) domain found in mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; MDC1, also called nuclear factor with BRCT domains 1 (NFBD1), is a nuclear chromatin-associated protein that is required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S and G2/M phases of the cell cycle. It directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. MDC1 contains a forkhead-associated (FHA) domain and two BRCT domains, as well as an internal 41-amino acid repeat sequence. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438717 [Multi-domain]  Cd Length: 97  Bit Score: 37.60  E-value: 5.85e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462494051  36 RADLCDVALrPQQEpglISGIHAELhaEPRGDDWrvSLED-HSSQGTLVNN-VRLPRGHRLELSDGDLLTFG 105
Cdd:cd22665    27 RDPSCSVVL-PDKS---VSKQHACI--EVDGGTH--LIEDlGSTNGTRIGNkVRLKPNVRYELIDGDLLLFG 90
FHA_RNF8 cd22663
forkhead associated (FHA) domain found in RING finger protein 8 (RNF8) and similar proteins; ...
 49-123 1.96e-03

forkhead associated (FHA) domain found in RING finger protein 8 (RNF8) and similar proteins; RNF8 is a telomere-associated E3 ubiquitin-protein ligase that plays an important role in DNA double-strand break (DSB) repair via histone ubiquitination. It is localized in the nucleus and interacts with class III E2s (UBE2E2, UbcH6, and UBE2E3), but not with other E2s (UbcH5, UbcH7, UbcH10, hCdc34, and hBendless). It recruits UBC13 for lysine 63-based self polyubiquitylation. Its deficiency causes neuronal pathology and cognitive decline, and its loss results in neuron degeneration. RNF8, together with RNF168, catalyzes a series of ubiquitylation events on substrates such as H2A and H2AX, with the H2AK13/15 ubiquitylation being particularly important for recruitment of repair factors p53-binding protein 1 (53BP1) or the RAP80-BRCA1 complex to sites of DSBs. Specially, RNF8 mediates the ubiquitination of gammaH2AX, and recruits 53BP1 and BRCA1 to DNA damage sites which promotes DNA damage response (DDR) and inhibits chromosomal instability. Moreover, RNF8 interacts with retinoid X receptor alpha (RXR alpha) and enhances its transcription-stimulating activity. It also regulates the rate of exit from mitosis and cytokinesis. RNF8 contains an N-terminal FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438715 [Multi-domain]  Cd Length: 110  Bit Score: 36.57  E-value: 1.96e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462494051  49 EPGLISGIHAELHAEPRGDdWRVslEDHSS-QGTLVNNVRLPRGHRLELSDGDLLTFGPEgPPGTSPSEFYFMFQQ 123
Cdd:cd22663    39 CPLMISRNHCVLKKNDEGQ-WTI--KDNKSlNGVWVNGERIEPLKPYPLNEGDLIQLGVP-PENKEPAEYVFNLIK 110
FHA_Ki67 cd22673
forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar ...
 36-105 2.29e-03

forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar proteins; Ki-67, also called antigen identified by monoclonal antibody Ki-67, antigen KI-67, or antigen Ki67, acts as a biological surfactant to disperse mitotic chromosomes. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Ki-67 binds DNA with a preference for supercoiled DNA and AT-rich DNA. It may also play a role in chromatin organization. Ki-67 contains an FHA domain at its N-terminus. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438725 [Multi-domain]  Cd Length: 95  Bit Score: 36.04  E-value: 2.29e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462494051  36 RADLCDVALrpqQEPGlISGIHAELHAEPRGddwRVSLEDHSS-QGTLVNNVRLPrgHRLELSDGDLLTFG 105
Cdd:cd22673    27 RDLSCDIRI---QLPG-VSREHCRIEVDENG---KAYLENLSTtNPTLVNGKAIE--KSAELKDGDVITIG 88
FHA_DUN1-like cd22683
forkhead associated (FHA) domain found in Saccharomyces cerevisiae DNA damage response protein ...
 36-105 2.77e-03

forkhead associated (FHA) domain found in Saccharomyces cerevisiae DNA damage response protein kinase DUN1 and similar proteins; DUN1 is a protein kinase that controls the DNA damage response in yeast. It phosphorylates SML1 on serine residues and cooperates with the PAN deadenylation complex in the regulation of RAD5 mRNA levels and cell survival in response to replicational stress. It contains an FHA domain, which is a small phosphopeptide recognition module.


Pssm-ID: 438735 [Multi-domain]  Cd Length: 96  Bit Score: 35.93  E-value: 2.77e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462494051  36 RADLCDVALrpqqEPGLISGIHAELHAEPRGDDwrvSLEDHSSQGTLVNNVRLpRGHRLELSDGDLLTFG 105
Cdd:cd22683    27 RSRSCDLVL----SDPSISRFHAELRLEQNGIN---VIDNNSANGTFINGKRI-KGKTYILKNGDIIVFG 88
FHA_PPP1R8 cd22674
forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 ...
 31-105 9.17e-03

forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 (PPP1R8) and similar proteins; PPP1R8, also called nuclear inhibitor of protein phosphatase 1 (NIPP-1), is an inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. It may also be involved in pre-mRNA splicing and binds DNA and might act as a transcriptional repressor. PPP1R8 seems to be required for cell proliferation. PPP1R8 contains an FHA domain that mediates interactions with threonine-phosphorylated maternal embryonic leucine zipper kinase (MELK). The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438726 [Multi-domain]  Cd Length: 108  Bit Score: 34.55  E-value: 9.17e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462494051  31 YRLGHRADLCDVALRPQQepglISGIHAEL--HaeprGDDWRVSLED-HSSQGTLVNNVRLPRGHRLELSDGDLLTFG 105
Cdd:cd22674    29 YLFGRNSDVCDFVLDHPS----CSRVHAALvyH----KHLNRVFLIDlGSTHGTFVGGIRLEPHKPQQLPIDSTLRFG 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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