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Conserved domains on  [gi|2462497197|ref|XP_054188224|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon isoform X1 [Homo sapiens]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0006644
PubMed:  18287005|18931347|18718904|37611890
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 1-112 6.29e-35

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 122.35  E-value: 6.29e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497197   1 MRNKLQSYVDAGTPMYLVIFPEGTRYNPEQTKVlsaSQAFAAQRGLAVLKHVLTPRIKATHVAFDCMKNYLDAIYDVTVV 80
Cdd:cd07990    91 IKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKER---SQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDAVDAVYDVTIA 167

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462497197  81 YEGKDdggqrrESPTMTEFLCKECPKIHIHID 112
Cdd:cd07990   168 YPDGK------PPSEQRLLLGGKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 107-161 2.31e-12

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 59.89  E-value: 2.31e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462497197 107 IHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEFYE----SPDPERRKRFPGKSV 161
Cdd:pfam16076  10 VHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYEtgtfFPGKEHIIPRRLKSL 68
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 1-112 6.29e-35

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 122.35  E-value: 6.29e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497197   1 MRNKLQSYVDAGTPMYLVIFPEGTRYNPEQTKVlsaSQAFAAQRGLAVLKHVLTPRIKATHVAFDCMKNYLDAIYDVTVV 80
Cdd:cd07990    91 IKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKER---SQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDAVDAVYDVTIA 167

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462497197  81 YEGKDdggqrrESPTMTEFLCKECPKIHIHID 112
Cdd:cd07990   168 YPDGK------PPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 1-182 2.25e-33

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 122.89  E-value: 2.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497197   1 MRNKLQSYVDAGTPMYLVIFPEGTRYNpEQTKVlsASQAFAAQRGLAVLKHVLTPRIKATHVAFDCMKNYLDAIYDVTVV 80
Cdd:PLN02510  159 IRQMLSSFKDPRDPLWLALFPEGTDYT-EAKCQ--RSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRCSLDAVYDVTIG 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497197  81 YegkddggqRRESPTMTEFLCKECP-KIHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEFYespdpeRRKRFPGK 159
Cdd:PLN02510  236 Y--------KHRCPSFLDNVFGIDPsEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY------AQGHFPNE 301

                         170       180
                  ....*....|....*....|...
gi 2462497197 160 SVNSKLSIKKTLPSMLILSGLTA 182
Cdd:PLN02510  302 GTEGELSTLKCLANFLAVIALTT 324
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 107-161 2.31e-12

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 59.89  E-value: 2.31e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462497197 107 IHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEFYE----SPDPERRKRFPGKSV 161
Cdd:pfam16076  10 VHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYEtgtfFPGKEHIIPRRLKSL 68
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 14-49 2.57e-03

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 36.56  E-value: 2.57e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462497197   14 PMYLVIFPEGTRYNPEQTKVLSASQAFAAQRGLAVL 49
Cdd:smart00563  75 GEWLLIFPEGTRSRPGKLLPFKKGAARLALEAGVPI 110
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 1-112 6.29e-35

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 122.35  E-value: 6.29e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497197   1 MRNKLQSYVDAGTPMYLVIFPEGTRYNPEQTKVlsaSQAFAAQRGLAVLKHVLTPRIKATHVAFDCMKNYLDAIYDVTVV 80
Cdd:cd07990    91 IKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKER---SQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDAVDAVYDVTIA 167

                          90       100       110
                  ....*....|....*....|....*....|..
gi 2462497197  81 YEGKDdggqrrESPTMTEFLCKECPKIHIHID 112
Cdd:cd07990   168 YPDGK------PPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 1-182 2.25e-33

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 122.89  E-value: 2.25e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497197   1 MRNKLQSYVDAGTPMYLVIFPEGTRYNpEQTKVlsASQAFAAQRGLAVLKHVLTPRIKATHVAFDCMKNYLDAIYDVTVV 80
Cdd:PLN02510  159 IRQMLSSFKDPRDPLWLALFPEGTDYT-EAKCQ--RSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRCSLDAVYDVTIG 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497197  81 YegkddggqRRESPTMTEFLCKECP-KIHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEFYespdpeRRKRFPGK 159
Cdd:PLN02510  236 Y--------KHRCPSFLDNVFGIDPsEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY------AQGHFPNE 301

                         170       180
                  ....*....|....*....|...
gi 2462497197 160 SVNSKLSIKKTLPSMLILSGLTA 182
Cdd:PLN02510  302 GTEGELSTLKCLANFLAVIALTT 324
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 1-144 7.34e-26

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 102.51  E-value: 7.34e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497197   1 MRNKLQSYVDAGTPMYLVIFPEGTRYNPEQtkvLSASQAFAAQRGLAVLKHVLTPRIKATHVAFDCMKNYLDAIYDVTVV 80
Cdd:PLN02380  151 LKSGFQRLKDFPRPFWLALFVEGTRFTQAK---LLAAQEYAASRGLPVPRNVLIPRTKGFVSAVSNMRSFVPAIYDVTVA 227

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462497197  81 YegkdDGGQRreSPTMTEFLCKECPKIHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEF 144
Cdd:PLN02380  228 V----PKGQP--APTMLRIFRGQSSVVHVHIKRHSMKELPETDDGIAQWCKDVFVAKDALLDKH 285
PRK14014 PRK14014
putative acyltransferase; Provisional
 13-147 1.68e-12

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 64.87  E-value: 1.68e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497197  13 TPMYLVIFPEGTRYNPEqtKVLSASQAFaaqrglavlKHVLTPriKATHVAF--DCMKNYLDAIYDVTVVYEGKDdggqr 90
Cdd:PRK14014  173 MPTTIVNFVEGTRFTPE--KHQQQQSPY---------QHLLKP--KAGGIAFalNAMGEQFDGLLDVTIVYPDGR----- 234

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462497197  91 resPTMTEFLCKECPKIHIHIDRIdkkDVPEE-----------QEHMRRWLHERFEIKDKMLIEFYES 147
Cdd:PRK14014  235 ---PSFWDLLSGRVKKIVVHVRLL---PIPEEligdyfndkefRRRFQQWLNQLWQEKDQLIEQLLAQ 296
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 107-161 2.31e-12

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 59.89  E-value: 2.31e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462497197 107 IHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEFYE----SPDPERRKRFPGKSV 161
Cdd:pfam16076  10 VHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYEtgtfFPGKEHIIPRRLKSL 68
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 14-49 2.57e-03

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 36.56  E-value: 2.57e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462497197   14 PMYLVIFPEGTRYNPEQTKVLSASQAFAAQRGLAVL 49
Cdd:smart00563  75 GEWLLIFPEGTRSRPGKLLPFKKGAARLALEAGVPI 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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