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Conserved domains on  [gi|2462497603|ref|XP_054188384|]
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formin-binding protein 4 isoform X5 [Homo sapiens]

Protein Classification

WW domain-containing protein( domain architecture ID 10449607)

WW domain-containing protein; the WW domain mediates protein-protein interaction via proline-rich motifs, such as PPxY

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 598-629 4.39e-08

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


:

Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 49.45  E-value: 4.39e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462497603 598 PKGWSCHWDRDHRRYFYvNEQSGESQWEFPDG 629
Cdd:cd00201     1 PPGWEERWDPDGRVYYY-NHNTKETQWEDPRE 31
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 219-246 1.31e-07

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


:

Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 47.88  E-value: 1.31e-07
                          10        20
                  ....*....|....*....|....*...
gi 2462497603 219 DWQEVWDENtGCYYYWNTQTNEVTWELP 246
Cdd:pfam00397   4 GWEERWDPD-GRVYYYNHETGETQWEKP 30
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 5-103 5.95e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 5.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497603    5 SRAVPGRRPILQLSPPG----PRGSTP-------------GRDPEPEPDTEPDSTAAVPSQPAPSAATTTTTAVTAAAAS 67
Cdd:PHA03247  2659 GRVSRPRRARRLGRAAQasspPQRPRRraarptvgsltslADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAA 2738

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2462497603   68 DDSPSEDEQEAVQEVPRVVQNPPKPVMTTRPTAVKA 103
Cdd:PHA03247  2739 PAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA 2774
 
Name Accession Description Interval E-value
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 598-629 4.39e-08

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 49.45  E-value: 4.39e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462497603 598 PKGWSCHWDRDHRRYFYvNEQSGESQWEFPDG 629
Cdd:cd00201     1 PPGWEERWDPDGRVYYY-NHNTKETQWEDPRE 31
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 219-246 1.31e-07

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 47.88  E-value: 1.31e-07
                          10        20
                  ....*....|....*....|....*...
gi 2462497603 219 DWQEVWDENtGCYYYWNTQTNEVTWELP 246
Cdd:pfam00397   4 GWEERWDPD-GRVYYYNHETGETQWEKP 30
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 598-627 2.56e-07

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 47.11  E-value: 2.56e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462497603 598 PKGWSCHWDRDhRRYFYVNEQSGESQWEFP 627
Cdd:pfam00397   2 PPGWEERWDPD-GRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 218-246 1.26e-06

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 45.21  E-value: 1.26e-06
                          10        20
                  ....*....|....*....|....*....
gi 2462497603 218 GDWQEVWDENtGCYYYWNTQTNEVTWELP 246
Cdd:cd00201     2 PGWEERWDPD-GRVYYYNHNTKETQWEDP 29
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 598-629 2.67e-06

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 44.13  E-value: 2.67e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462497603  598 PKGWSCHWDRDhRRYFYVNEQSGESQWEFPDG 629
Cdd:smart00456   3 PPGWEERKDPD-GRPYYYNHETKETQWEKPRE 33
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 220-247 1.20e-05

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 42.59  E-value: 1.20e-05
                           10        20
                   ....*....|....*....|....*...
gi 2462497603  220 WQEVWDENtGCYYYWNTQTNEVTWELPQ 247
Cdd:smart00456   6 WEERKDPD-GRPYYYNHETKETQWEKPR 32
PHA03247 PHA03247
large tegument protein UL36; Provisional
 5-103 5.95e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 5.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497603    5 SRAVPGRRPILQLSPPG----PRGSTP-------------GRDPEPEPDTEPDSTAAVPSQPAPSAATTTTTAVTAAAAS 67
Cdd:PHA03247  2659 GRVSRPRRARRLGRAAQasspPQRPRRraarptvgsltslADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAA 2738

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2462497603   68 DDSPSEDEQEAVQEVPRVVQNPPKPVMTTRPTAVKA 103
Cdd:PHA03247  2739 PAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA 2774
 
Name Accession Description Interval E-value
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 598-629 4.39e-08

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 49.45  E-value: 4.39e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 2462497603 598 PKGWSCHWDRDHRRYFYvNEQSGESQWEFPDG 629
Cdd:cd00201     1 PPGWEERWDPDGRVYYY-NHNTKETQWEDPRE 31
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 219-246 1.31e-07

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 47.88  E-value: 1.31e-07
                          10        20
                  ....*....|....*....|....*...
gi 2462497603 219 DWQEVWDENtGCYYYWNTQTNEVTWELP 246
Cdd:pfam00397   4 GWEERWDPD-GRVYYYNHETGETQWEKP 30
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 598-627 2.56e-07

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 47.11  E-value: 2.56e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462497603 598 PKGWSCHWDRDhRRYFYVNEQSGESQWEFP 627
Cdd:pfam00397   2 PPGWEERWDPD-GRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 218-246 1.26e-06

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 45.21  E-value: 1.26e-06
                          10        20
                  ....*....|....*....|....*....
gi 2462497603 218 GDWQEVWDENtGCYYYWNTQTNEVTWELP 246
Cdd:cd00201     2 PGWEERWDPD-GRVYYYNHNTKETQWEDP 29
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 598-629 2.67e-06

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 44.13  E-value: 2.67e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462497603  598 PKGWSCHWDRDhRRYFYVNEQSGESQWEFPDG 629
Cdd:smart00456   3 PPGWEERKDPD-GRPYYYNHETKETQWEKPRE 33
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 220-247 1.20e-05

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 42.59  E-value: 1.20e-05
                           10        20
                   ....*....|....*....|....*...
gi 2462497603  220 WQEVWDENtGCYYYWNTQTNEVTWELPQ 247
Cdd:smart00456   6 WEERKDPD-GRPYYYNHETKETQWEKPR 32
PHA03247 PHA03247
large tegument protein UL36; Provisional
 5-103 5.95e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 5.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462497603    5 SRAVPGRRPILQLSPPG----PRGSTP-------------GRDPEPEPDTEPDSTAAVPSQPAPSAATTTTTAVTAAAAS 67
Cdd:PHA03247  2659 GRVSRPRRARRLGRAAQasspPQRPRRraarptvgsltslADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAA 2738

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2462497603   68 DDSPSEDEQEAVQEVPRVVQNPPKPVMTTRPTAVKA 103
Cdd:PHA03247  2739 PAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA 2774
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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