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Conserved domains on  [gi|2462496564|ref|XP_054188913|]
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ankyrin repeat domain-containing protein 36A isoform X16 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
1465-1755 4.09e-123

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


:

Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 389.73  E-value: 4.09e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1465 NRLMQDEIARLRLEKDTIKNQNLEK--KYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLE 1542
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKekKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1543 KQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHV-------LILSLQLSKAESKS 1615
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVsnlrdenEILSQQLSKAESKA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1616 RVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQ----ERFCQLKKQNMLLQQQLDDA 1691
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQesleERLAQLQSENMLLRQQLEDA 240
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462496564 1692 RNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAER 1755
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-197 6.18e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.02  E-value: 6.18e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   36 IHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACAT 115
Cdd:COG0666     58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  116 LLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKVKMVEFLLKKKANVNAIDY 195
Cdd:COG0666    138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN 217

                   ..
gi 2462496564  196 LG 197
Cdd:COG0666    218 DG 219
CCDC158 super family cl37899
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1228-1858 3.80e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


The actual alignment was detected with superfamily member pfam15921:

Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 62.06  E-value: 3.80e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1228 KNSVLNTATKMKDVQTSTPAEQDLEMASEGEQKRLEEyennqpQVKNQIH----SRDDLDDIIQSSQTVSEDGDSLCCNC 1303
Cdd:pfam15921  109 RQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRN------QLQNTVHeleaAKCLKEDMLEDSNTQIEQLRKMMLSH 182
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1304 KNVI-----LLIDQHEMKCK-----DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKS 1373
Cdd:pfam15921  183 EGVLqeirsILVDFEEASGKkiyehDSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLL 262
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1374 QLKHEilELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVS 1453
Cdd:pfam15921  263 QQHQD--RIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMY 340
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1454 EtDEKEDLLHENRLMQDEIARLRLEKDTIKNQ--NLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIAcysgqlAALT 1531
Cdd:pfam15921  341 E-DKIEELEKQLVLANSELTEARTERDQFSQEsgNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTG------NSIT 413
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1532 DENttLRSKLEKQRESRQRLETEMQSYHcrlnaarcdhDQSHSSKRDQELAFQG---TVDKCRHLQENLNSHVLILSLQL 1608
Cdd:pfam15921  414 IDH--LRRELDDRNMEVQRLEALLKAMK----------SECQGQMERQMAAIQGkneSLEKVSSLTAQLESTKEMLRKVV 481
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1609 SKAESKSRVLKTELHYTGE---ALKEKALVFEHVQSELKQKQS----QMKDIEKMYKSG---YNTMEKCIEKQERFCQLK 1678
Cdd:pfam15921  482 EELTAKKMTLESSERTVSDltaSLQEKERAIEATNAEITKLRSrvdlKLQELQHLKNEGdhlRNVQTECEALKLQMAEKD 561
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1679 KQNMLLQQQLDDARNKADNQEK---AILNIQARCDARVQNLQAECRKHRLLLEEDNKMlVNELnHSKEKECQYEKEK--- 1752
Cdd:pfam15921  562 KVIEILRQQIENMTQLVGQHGRtagAMQVEKAQLEKEINDRRLELQEFKILKDKKDAK-IREL-EARVSDLELEKVKlvn 639
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1753 --AEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLD----QMRSQFQEIQDQLTATIRCTKEME 1826
Cdd:pfam15921  640 agSERLRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMEtttnKLKMQLKSAQSELEQTRNTLKSME 719
                          650       660       670
                   ....*....|....*....|....*....|...
gi 2462496564 1827 G-DTQKLEVEHVMMRKIIKKQdDQIERLEKILQ 1858
Cdd:pfam15921  720 GsDGHAMKVAMGMQKQITAKR-GQIDALQSKIQ 751
PTZ00121 super family cl31754
MAEBL; Provisional
636-1107 9.07e-06

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.91  E-value: 9.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  636 SSQKQPALKATTDEEDSVSNIA-TEIKDGEKSGTVSSQKQPALKATTDEE----DSVSNIATEIKDGE---KSGTVSSQK 707
Cdd:PTZ00121  1327 AKKKADAAKKKAEEAKKAAEAAkAEAEAAADEAEAAEEKAEAAEKKKEEAkkkaDAAKKKAEEKKKADeakKKAEEDKKK 1406
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  708 QPALKATTDEK---DSVSNIATEIKDGEKSGTVSSQKPPALTATSDEEGS-----VLSIARENKDGEKSRTVSSRKKPAL 779
Cdd:PTZ00121  1407 ADELKKAAAAKkkaDEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAkkaeeAKKKAEEAKKADEAKKKAEEAKKAD 1486
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  780 KATSDEKDSFSNITRGKKDGEISRKVSSQKPPTLKGTSDEedsvLGIARENKDGEKSRTVSSEKppglKASSAEKDSVLN 859
Cdd:PTZ00121  1487 EAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADE----AKKAEEAKKADEAKKAEEKK----KADELKKAEELK 1558
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  860 IARGKKDGEKTKRVSSRKKPSLEATSDEKDSfsnitREKKDGEISRKVSSQKPPALKGTSDEEDSVLGIARENKDGEKSR 939
Cdd:PTZ00121  1559 KAEEKKKAEEAKKAEEDKNMALRKAEEAKKA-----EEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKK 1633
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  940 TVSSEKPPGL----KATSDEKDSVLNIARGKKDGEKTRTVSSQKPPTLKATSDEEDSVLSIARENKDGEKSRTV----SS 1011
Cdd:PTZ00121  1634 KVEQLKKKEAeekkKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELkkkeAE 1713
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1012 EKPSGLKATSAEKDSVLNIARGKKYGEKTKRvssrKKPALKATSDEKDSVLYIAREKKdgEKSRTVSSPKQPALKAICDK 1091
Cdd:PTZ00121  1714 EKKKAEELKKAEEENKIKAEEAKKEAEEDKK----KAEEAKKDEEEKKKIAHLKKEEE--KKAEEIRKEKEAVIEEELDE 1787
                          490
                   ....*....|....*.
gi 2462496564 1092 EDSVPNMATEKKDEQI 1107
Cdd:PTZ00121  1788 EDEKRRMEVDKKIKDI 1803
 
Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
1465-1755 4.09e-123

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 389.73  E-value: 4.09e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1465 NRLMQDEIARLRLEKDTIKNQNLEK--KYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLE 1542
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKekKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1543 KQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHV-------LILSLQLSKAESKS 1615
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVsnlrdenEILSQQLSKAESKA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1616 RVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQ----ERFCQLKKQNMLLQQQLDDA 1691
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQesleERLAQLQSENMLLRQQLEDA 240
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462496564 1692 RNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAER 1755
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-197 6.18e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.02  E-value: 6.18e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   36 IHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACAT 115
Cdd:COG0666     58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  116 LLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKVKMVEFLLKKKANVNAIDY 195
Cdd:COG0666    138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN 217

                   ..
gi 2462496564  196 LG 197
Cdd:COG0666    218 DG 219
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-128 5.49e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.32  E-value: 5.49e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   36 IHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSrRCELNLCDrEDRTPLIKAVQLRQEACAT 115
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78
                           90
                   ....*....|...
gi 2462496564  116 LLLQNGANPNITD 128
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
36-197 1.18e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 78.55  E-value: 1.18e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   36 IHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLAC-----ATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQ--L 108
Cdd:PHA03100    39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnikynLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISkkS 118
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  109 RQEACATLLLQNGANPNITDFFGRTALHYAV-YNE-DTSMIEKLLSHGTNIEECSKCEY----------------QPLLF 170
Cdd:PHA03100   119 NSYSIVEYLLDNGANVNIKNSDGENLLHLYLeSNKiDLKILKLLIDKGVDINAKNRVNYllsygvpinikdvygfTPLHY 198
                          170       180
                   ....*....|....*....|....*..
gi 2462496564  171 AVSRRKVKMVEFLLKKKANVNAIDYLG 197
Cdd:PHA03100   199 AVYNNNPEFVKYLLDLGANPNLVNKYG 225
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1228-1858 3.80e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 62.06  E-value: 3.80e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1228 KNSVLNTATKMKDVQTSTPAEQDLEMASEGEQKRLEEyennqpQVKNQIH----SRDDLDDIIQSSQTVSEDGDSLCCNC 1303
Cdd:pfam15921  109 RQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRN------QLQNTVHeleaAKCLKEDMLEDSNTQIEQLRKMMLSH 182
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1304 KNVI-----LLIDQHEMKCK-----DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKS 1373
Cdd:pfam15921  183 EGVLqeirsILVDFEEASGKkiyehDSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLL 262
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1374 QLKHEilELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVS 1453
Cdd:pfam15921  263 QQHQD--RIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMY 340
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1454 EtDEKEDLLHENRLMQDEIARLRLEKDTIKNQ--NLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIAcysgqlAALT 1531
Cdd:pfam15921  341 E-DKIEELEKQLVLANSELTEARTERDQFSQEsgNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTG------NSIT 413
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1532 DENttLRSKLEKQRESRQRLETEMQSYHcrlnaarcdhDQSHSSKRDQELAFQG---TVDKCRHLQENLNSHVLILSLQL 1608
Cdd:pfam15921  414 IDH--LRRELDDRNMEVQRLEALLKAMK----------SECQGQMERQMAAIQGkneSLEKVSSLTAQLESTKEMLRKVV 481
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1609 SKAESKSRVLKTELHYTGE---ALKEKALVFEHVQSELKQKQS----QMKDIEKMYKSG---YNTMEKCIEKQERFCQLK 1678
Cdd:pfam15921  482 EELTAKKMTLESSERTVSDltaSLQEKERAIEATNAEITKLRSrvdlKLQELQHLKNEGdhlRNVQTECEALKLQMAEKD 561
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1679 KQNMLLQQQLDDARNKADNQEK---AILNIQARCDARVQNLQAECRKHRLLLEEDNKMlVNELnHSKEKECQYEKEK--- 1752
Cdd:pfam15921  562 KVIEILRQQIENMTQLVGQHGRtagAMQVEKAQLEKEINDRRLELQEFKILKDKKDAK-IREL-EARVSDLELEKVKlvn 639
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1753 --AEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLD----QMRSQFQEIQDQLTATIRCTKEME 1826
Cdd:pfam15921  640 agSERLRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMEtttnKLKMQLKSAQSELEQTRNTLKSME 719
                          650       660       670
                   ....*....|....*....|....*....|...
gi 2462496564 1827 G-DTQKLEVEHVMMRKIIKKQdDQIERLEKILQ 1858
Cdd:pfam15921  720 GsDGHAMKVAMGMQKQITAKR-GQIDALQSKIQ 751
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1471-1826 3.24e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 58.91  E-value: 3.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1471 EIARLRLEKdtiKNQNLEKkyLKD--FEIvKRKHEDLQ---------KALKRNGETLAKTIacYSGQLAALTDENTTLRS 1539
Cdd:TIGR02168  175 KETERKLER---TRENLDR--LEDilNEL-ERQLKSLErqaekaeryKELKAELRELELAL--LVLRLEELREELEELQE 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1540 KLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQE---LAFQGTVDKC----RHLQE---NLNSHVLILSLQLS 1609
Cdd:TIGR02168  247 ELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQkelYALANEISRLeqqkQILRErlaNLERQLEELEAQLE 326
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1610 KAESKSRVLKTELHytgeALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQER-FCQLKKQNMLLQQQL 1688
Cdd:TIGR02168  327 ELESKLDELAEELA----ELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSkVAQLELQIASLNNEI 402
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1689 DDARNKADNQEKAILNIQARCDARVQNLQ-AECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVAVRQLQQKRD 1767
Cdd:TIGR02168  403 ERLEARLERLEDRRERLQQEIEELLKKLEeAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAER 482
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462496564 1768 DVLNKGSATKALLDASSRHCTYlengmQDSRKKLDQMRSQFQEIQDQLTATIRCTKEME 1826
Cdd:TIGR02168  483 ELAQLQARLDSLERLQENLEGF-----SEGVKALLKNQSGLSGILGVLSELISVDEGYE 536
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1351-1836 2.56e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.54  E-value: 2.56e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1351 IRKLKNKASVLQKRISEKEEIKSQlkhEILELEKELcslrfaiqqeKKKRRNVEEVHQKVREKLRITEEQYRIEAdvtkp 1430
Cdd:COG4717     48 LERLEKEADELFKPQGRKPELNLK---ELKELEEEL----------KEAEEKEEEYAELQEELEELEEELEELEA----- 109
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1431 ikpALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEKKYLKDfEIvKRKHEDLQKALK 1510
Cdd:COG4717    110 ---ELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEA-EL-AELQEELEELLE 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1511 RNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAArcdhdqshsskrdqelafqgtvDKC 1590
Cdd:COG4717    185 QLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAA----------------------ALE 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1591 RHLQENLNShVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMyksGYNTMEKCIEK 1670
Cdd:COG4717    243 ERLKEARLL-LLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEEL---QALPALEELEE 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1671 QERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRL-LLEEDNKMLVNELNHSKEKECQYE 1749
Cdd:COG4717    319 EELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAaLLAEAGVEDEEELRAALEQAEEYQ 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1750 KEKAEREVAVRQLQQKRDDVLnkgsatkALLDASSRhcTYLENGMQDSRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDT 1829
Cdd:COG4717    399 ELKEELEELEEQLEELLGELE-------ELLEALDE--EELEEELEELEEELEELEEELEELREELAELEAELEQLEEDG 469

                   ....*..
gi 2462496564 1830 QKLEVEH 1836
Cdd:COG4717    470 ELAELLQ 476
PTZ00121 PTZ00121
MAEBL; Provisional
636-1107 9.07e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.91  E-value: 9.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  636 SSQKQPALKATTDEEDSVSNIA-TEIKDGEKSGTVSSQKQPALKATTDEE----DSVSNIATEIKDGE---KSGTVSSQK 707
Cdd:PTZ00121  1327 AKKKADAAKKKAEEAKKAAEAAkAEAEAAADEAEAAEEKAEAAEKKKEEAkkkaDAAKKKAEEKKKADeakKKAEEDKKK 1406
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  708 QPALKATTDEK---DSVSNIATEIKDGEKSGTVSSQKPPALTATSDEEGS-----VLSIARENKDGEKSRTVSSRKKPAL 779
Cdd:PTZ00121  1407 ADELKKAAAAKkkaDEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAkkaeeAKKKAEEAKKADEAKKKAEEAKKAD 1486
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  780 KATSDEKDSFSNITRGKKDGEISRKVSSQKPPTLKGTSDEedsvLGIARENKDGEKSRTVSSEKppglKASSAEKDSVLN 859
Cdd:PTZ00121  1487 EAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADE----AKKAEEAKKADEAKKAEEKK----KADELKKAEELK 1558
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  860 IARGKKDGEKTKRVSSRKKPSLEATSDEKDSfsnitREKKDGEISRKVSSQKPPALKGTSDEEDSVLGIARENKDGEKSR 939
Cdd:PTZ00121  1559 KAEEKKKAEEAKKAEEDKNMALRKAEEAKKA-----EEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKK 1633
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  940 TVSSEKPPGL----KATSDEKDSVLNIARGKKDGEKTRTVSSQKPPTLKATSDEEDSVLSIARENKDGEKSRTV----SS 1011
Cdd:PTZ00121  1634 KVEQLKKKEAeekkKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELkkkeAE 1713
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1012 EKPSGLKATSAEKDSVLNIARGKKYGEKTKRvssrKKPALKATSDEKDSVLYIAREKKdgEKSRTVSSPKQPALKAICDK 1091
Cdd:PTZ00121  1714 EKKKAEELKKAEEENKIKAEEAKKEAEEDKK----KAEEAKKDEEEKKKIAHLKKEEE--KKAEEIRKEKEAVIEEELDE 1787
                          490
                   ....*....|....*.
gi 2462496564 1092 EDSVPNMATEKKDEQI 1107
Cdd:PTZ00121  1788 EDEKRRMEVDKKIKDI 1803
PTZ00121 PTZ00121
MAEBL; Provisional
1345-1757 1.79e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.14  E-value: 1.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1345 EQLRVKIRKLKNKASVLQKRISEKEEI-----KSQLKHEILELEKELCSLRFAIQQEKK--KRRNVEEVHQKVREKLRit 1417
Cdd:PTZ00121  1394 DEAKKKAEEDKKKADELKKAAAAKKKAdeakkKAEEKKKADEAKKKAEEAKKADEAKKKaeEAKKAEEAKKKAEEAKK-- 1471
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1418 EEQYRIEADVTKPIKPALKSAEvELKTGGNNSNQVSETDEKEDLLH--ENRLMQDEiarLRLEKDTIKNQNLEKKYLKDF 1495
Cdd:PTZ00121  1472 ADEAKKKAEEAKKADEAKKKAE-EAKKKADEAKKAAEAKKKADEAKkaEEAKKADE---AKKAEEAKKADEAKKAEEKKK 1547
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1496 EIVKRKHEDLQKALKRNGETLAKTiacysgqlaALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSS 1575
Cdd:PTZ00121  1548 ADELKKAEELKKAEEKKKAEEAKK---------AEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEA 1618
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1576 K-RDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIE 1654
Cdd:PTZ00121  1619 KiKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEA 1698
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1655 KMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDDARNKADNQEKAI--LNIQARCDARVQNLQAECRKHRLLLEEDNK 1732
Cdd:PTZ00121  1699 EEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAeeAKKDEEEKKKIAHLKKEEEKKAEEIRKEKE 1778
                          410       420
                   ....*....|....*....|....*
gi 2462496564 1733 MLVNELNHSKEKECQYEKEKAEREV 1757
Cdd:PTZ00121  1779 AVIEEELDEEDEKRRMEVDKKIKDI 1803
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1350-1557 2.02e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.99  E-value: 2.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1350 KIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKLRITEEQY-------- 1421
Cdd:COG4942     21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIaelraele 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1422 RIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHE-NRLMQDEIARLRLEKDTIKNQNlekkylKDFEIVKR 1500
Cdd:COG4942    101 AQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYlAPARREQAEELRADLAELAALR------AELEAERA 174
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496564 1501 KHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQS 1557
Cdd:COG4942    175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
67-154 7.20e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 47.77  E-value: 7.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   67 TALHLACATGQPEMVHLLVSR------RCELNLCDREDRTPLIKAVQLR--------QEACATLLLQNGANPNITDFFGR 132
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERgasvpaRACGDFFVKSQGVDSFYHGESPlnaaaclgSPSIVALLSEDPADILTADSLGN 209
                           90       100       110
                   ....*....|....*....|....*....|.
gi 2462496564  133 TALHYAVYNED---------TSMIEKLLSHG 154
Cdd:TIGR00870  210 TLLHLLVMENEfkaeyeelsCQMYNFALSLL 240
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
131-159 1.93e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 1.93e-04
                            10        20
                    ....*....|....*....|....*....
gi 2462496564   131 GRTALHYAVYNEDTSMIEKLLSHGTNIEE 159
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
36-187 5.44e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 5.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   36 IHRAVLHGNLEKLKYLLltyyDANKRDRKE---------RTALHLACATGQPEMVHLLVSRRCELN------LCDREDRT 100
Cdd:cd22192     55 LHVAALYDNLEAAVVLM----EAAPELVNEpmtsdlyqgETALHIAVVNQNLNLVRELIARGADVVspratgTFFRPGPK 130
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  101 --------PLIKAVQLRQEACATLLLQNGANPNITDFFGRTALHYAVYNEDTS----MIEKLLSHGTNIEECS------K 162
Cdd:cd22192    131 nliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTfacqMYDLILSYDKEDDLQPldlvpnN 210
                          170       180
                   ....*....|....*....|....*
gi 2462496564  163 CEYQPLLFAVSRRKVKMVEFLLKKK 187
Cdd:cd22192    211 QGLTPFKLAAKEGNIVMFQHLVQKR 235
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1345-1582 2.28e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 43.11  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1345 EQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKL-RITEEQYRI 1423
Cdd:PRK02224   352 DDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERdELREREAEL 431
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1424 EADVtKPIKPALKSAEVELKTGG--------NNSNQVSETDEKEDLLHEnrlMQDEIARLRLEKDTIKNQNLEKKYLKDF 1495
Cdd:PRK02224   432 EATL-RTARERVEEAEALLEAGKcpecgqpvEGSPHVETIEEDRERVEE---LEAELEDLEEEVEEVEERLERAEDLVEA 507
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1496 EIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSyhCRLNAARCDHDQSHSS 1575
Cdd:PRK02224   508 EDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEE--AREEVAELNSKLAELK 585

                   ....*..
gi 2462496564 1576 KRDQELA 1582
Cdd:PRK02224   586 ERIESLE 592
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1334-1563 3.82e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 42.36  E-value: 3.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1334 KRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELcsLRFAIQQEKKKRRNVEEVHQKVREK 1413
Cdd:TIGR02169  736 KERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARL--SHSRIPEIQAELSKLEEEVSRIEAR 813
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1414 LRiteeqyrieadvtkpikpalksaEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRlekDTIKNQNLEKkylk 1493
Cdd:TIGR02169  814 LR-----------------------EIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIE---KEIENLNGKK---- 863
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1494 dfEIVKRKHEDLQKALKRngetlaktiacYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLN 1563
Cdd:TIGR02169  864 --EELEEELEELEAALRD-----------LESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLS 920
 
Name Accession Description Interval E-value
CCDC144C pfam14915
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ...
1465-1755 4.09e-123

CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.


Pssm-ID: 464371 [Multi-domain]  Cd Length: 304  Bit Score: 389.73  E-value: 4.09e-123
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1465 NRLMQDEIARLRLEKDTIKNQNLEK--KYLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLE 1542
Cdd:pfam14915    1 NCMLQDEIAMLRLEIDTIKNQNQEKekKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1543 KQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHV-------LILSLQLSKAESKS 1615
Cdd:pfam14915   81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVsnlrdenEILSQQLSKAESKA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1616 RVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQ----ERFCQLKKQNMLLQQQLDDA 1691
Cdd:pfam14915  161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQesleERLAQLQSENMLLRQQLEDA 240
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462496564 1692 RNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAER 1755
Cdd:pfam14915  241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-197 6.18e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.02  E-value: 6.18e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   36 IHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACAT 115
Cdd:COG0666     58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  116 LLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKVKMVEFLLKKKANVNAIDY 195
Cdd:COG0666    138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN 217

                   ..
gi 2462496564  196 LG 197
Cdd:COG0666    218 DG 219
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-212 1.01e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.55  E-value: 1.01e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   36 IHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACAT 115
Cdd:COG0666     91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  116 LLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKVKMVEFLLKKKANVNAIDY 195
Cdd:COG0666    171 LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDK 250
                          170
                   ....*....|....*..
gi 2462496564  196 LGSIFDLIYEYERKRYE 212
Cdd:COG0666    251 DGLTALLLAAAAGAALI 267
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
36-197 2.12e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.14  E-value: 2.12e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   36 IHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACAT 115
Cdd:COG0666    124 LHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVK 203
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  116 LLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKVKMVEFLLKKKANVNAIDY 195
Cdd:COG0666    204 LLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283

                   ..
gi 2462496564  196 LG 197
Cdd:COG0666    284 DL 285
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
28-197 3.13e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.59  E-value: 3.13e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   28 IKPYHLKRIHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQ 107
Cdd:COG0666     17 LLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAAR 96
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  108 LRQEACATLLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKVKMVEFLLKKK 187
Cdd:COG0666     97 NGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAG 176
                          170
                   ....*....|
gi 2462496564  188 ANVNAIDYLG 197
Cdd:COG0666    177 ADVNARDNDG 186
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-128 5.49e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.32  E-value: 5.49e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   36 IHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSrRCELNLCDrEDRTPLIKAVQLRQEACAT 115
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78
                           90
                   ....*....|...
gi 2462496564  116 LLLQNGANPNITD 128
Cdd:pfam12796   79 LLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
45-197 1.06e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 82.69  E-value: 1.06e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   45 LEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGANP 124
Cdd:COG0666      1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462496564  125 NITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKVKMVEFLLKKKANVNAIDYLG 197
Cdd:COG0666     81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDG 153
Ank_2 pfam12796
Ankyrin repeats (3 copies);
102-194 7.63e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.38  E-value: 7.63e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  102 LIKAVQLRQEACATLLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGtNIEECSKcEYQPLLFAVSRRKVKMVE 181
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA-DVNLKDN-GRTALHYAARSGHLEIVK 78
                           90
                   ....*....|...
gi 2462496564  182 FLLKKKANVNAID 194
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
36-197 1.18e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 78.55  E-value: 1.18e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   36 IHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLAC-----ATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQ--L 108
Cdd:PHA03100    39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnikynLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISkkS 118
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  109 RQEACATLLLQNGANPNITDFFGRTALHYAV-YNE-DTSMIEKLLSHGTNIEECSKCEY----------------QPLLF 170
Cdd:PHA03100   119 NSYSIVEYLLDNGANVNIKNSDGENLLHLYLeSNKiDLKILKLLIDKGVDINAKNRVNYllsygvpinikdvygfTPLHY 198
                          170       180
                   ....*....|....*....|....*..
gi 2462496564  171 AVSRRKVKMVEFLLKKKANVNAIDYLG 197
Cdd:PHA03100   199 AVYNNNPEFVKYLLDLGANPNLVNKYG 225
PHA02878 PHA02878
ankyrin repeat protein; Provisional
51-195 3.40e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 77.23  E-value: 3.40e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   51 LLLTY-YDANKRDR-KERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGANPNITD 128
Cdd:PHA02878   152 LLLSYgADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARD 231
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  129 FFGRTALHYAV-YNEDTSMIEKLLSHGTNIEECSKC-EYQPLLFAV-SRRKVKMvefLLKKKANVNAIDY 195
Cdd:PHA02878   232 KCGNTPLHISVgYCKDYDILKLLLEHGVDVNAKSYIlGLTALHSSIkSERKLKL---LLEYGADINSLNS 298
PHA02874 PHA02874
ankyrin repeat protein; Provisional
44-198 2.58e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 68.07  E-value: 2.58e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   44 NLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGAN 123
Cdd:PHA02874   103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462496564  124 PNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKvKMVEFLLkKKANVNAIDYLGS 198
Cdd:PHA02874   183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLI-NNASINDQDIDGS 255
PHA02878 PHA02878
ankyrin repeat protein; Provisional
36-198 5.76e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 67.21  E-value: 5.76e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   36 IHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACAT----GQPEMVHLLVSRRC-------------------ELN 92
Cdd:PHA02878    41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEpnklGMKEMIRSINKCSVfytlvaikdafnnrnveifKII 120
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   93 LCDREDRTPLIKAVQLRQ-------EACAT-LLLQNGANPNITD-FFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKC 163
Cdd:PHA02878   121 LTNRYKNIQTIDLVYIDKkskddiiEAEITkLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKT 200
                          170       180       190
                   ....*....|....*....|....*....|....*
gi 2462496564  164 EYQPLLFAVSRRKVKMVEFLLKKKANVNAIDYLGS 198
Cdd:PHA02878   201 NNSPLHHAVKHYNKPIVHILLENGASTDARDKCGN 235
PHA02875 PHA02875
ankyrin repeat protein; Provisional
36-193 9.91e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 66.17  E-value: 9.91e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   36 IHRAVLHGNLEKLKYLLLTYYDANKRDRKE-RTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACA 114
Cdd:PHA02875    72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDgMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI 151
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  115 TLLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLL-FAVSRRKVKMVEFLLKKKANVNAI 193
Cdd:PHA02875   152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALcYAIENNKIDIVRLFIKRGADCNIM 231
PHA02875 PHA02875
ankyrin repeat protein; Provisional
39-210 1.35e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 65.78  E-value: 1.35e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   39 AVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSR-----------RCELN-------------LC 94
Cdd:PHA02875     9 AILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHgaipdvkypdiESELHdaveegdvkaveeLL 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   95 D----------REDRTPLIKAVQLRQEACATLLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLLSHG--TNIEECsk 162
Cdd:PHA02875    89 DlgkfaddvfyKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKacLDIEDC-- 166
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 2462496564  163 CEYQPLLFAVSRRKVKMVEFLLKKKANVNAIDYLGSIFDLIYEYERKR 210
Cdd:PHA02875   167 CGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNK 214
PHA03100 PHA03100
ankyrin repeat protein; Provisional
30-194 1.73e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 65.46  E-value: 1.73e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   30 PYHLKRIHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACAT--GQPEMVHLLVSRRCELNLCDREDRTPLIKAVq 107
Cdd:PHA03100    71 PLHYLSNIKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYL- 149
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  108 lrqEACAT------LLLQNGANPN----------------ITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEY 165
Cdd:PHA03100   150 ---ESNKIdlkilkLLIDKGVDINaknrvnyllsygvpinIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGD 226
                          170       180
                   ....*....|....*....|....*....
gi 2462496564  166 QPLLFAVSRRKVKMVEFLLKKKANVNAID 194
Cdd:PHA03100   227 TPLHIAILNNNKEIFKLLLNNGPSIKTII 255
PHA02876 PHA02876
ankyrin repeat protein; Provisional
36-192 3.66e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.08  E-value: 3.66e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   36 IHRAVLHGNLEKL-KYLLLTYYDANKRDRKERTALHLACATG-QPEMVHLLVSRRCELNLCDREDRTPLIKAVQL-RQEA 112
Cdd:PHA02876   277 LHHASQAPSLSRLvPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLdRNKD 356
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  113 CATLLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKVKM-VEFLLKKKANVN 191
Cdd:PHA02876   357 IVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYMsVKTLIDRGANVN 436

                   .
gi 2462496564  192 A 192
Cdd:PHA02876   437 S 437
PHA03100 PHA03100
ankyrin repeat protein; Provisional
100-216 8.93e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.15  E-value: 8.93e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  100 TPLIKAVQLRQEACATLLLQNGANPNITDFFGRTALHY-----AVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSR 174
Cdd:PHA03100    37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYlsnikYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISK 116
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 2462496564  175 RK--VKMVEFLLKKKANVNAIDYLGsiFDLIYEYERKRYEDLPI 216
Cdd:PHA03100   117 KSnsYSIVEYLLDNGANVNIKNSDG--ENLLHLYLESNKIDLKI 158
Ank_4 pfam13637
Ankyrin repeats (many copies);
99-151 1.30e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 55.36  E-value: 1.30e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462496564   99 RTPLIKAVQLRQEACATLLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLL 151
Cdd:pfam13637    2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
32-85 3.16e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.20  E-value: 3.16e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462496564   32 HLKRIHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLV 85
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1228-1858 3.80e-09

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 62.06  E-value: 3.80e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1228 KNSVLNTATKMKDVQTSTPAEQDLEMASEGEQKRLEEyennqpQVKNQIH----SRDDLDDIIQSSQTVSEDGDSLCCNC 1303
Cdd:pfam15921  109 RQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRN------QLQNTVHeleaAKCLKEDMLEDSNTQIEQLRKMMLSH 182
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1304 KNVI-----LLIDQHEMKCK-----DCVHLLKIKNTFCLWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKS 1373
Cdd:pfam15921  183 EGVLqeirsILVDFEEASGKkiyehDSMSTMHFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELLL 262
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1374 QLKHEilELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTGGNNSNQVS 1453
Cdd:pfam15921  263 QQHQD--RIEQLISEHEVEITGLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMY 340
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1454 EtDEKEDLLHENRLMQDEIARLRLEKDTIKNQ--NLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIAcysgqlAALT 1531
Cdd:pfam15921  341 E-DKIEELEKQLVLANSELTEARTERDQFSQEsgNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTG------NSIT 413
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1532 DENttLRSKLEKQRESRQRLETEMQSYHcrlnaarcdhDQSHSSKRDQELAFQG---TVDKCRHLQENLNSHVLILSLQL 1608
Cdd:pfam15921  414 IDH--LRRELDDRNMEVQRLEALLKAMK----------SECQGQMERQMAAIQGkneSLEKVSSLTAQLESTKEMLRKVV 481
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1609 SKAESKSRVLKTELHYTGE---ALKEKALVFEHVQSELKQKQS----QMKDIEKMYKSG---YNTMEKCIEKQERFCQLK 1678
Cdd:pfam15921  482 EELTAKKMTLESSERTVSDltaSLQEKERAIEATNAEITKLRSrvdlKLQELQHLKNEGdhlRNVQTECEALKLQMAEKD 561
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1679 KQNMLLQQQLDDARNKADNQEK---AILNIQARCDARVQNLQAECRKHRLLLEEDNKMlVNELnHSKEKECQYEKEK--- 1752
Cdd:pfam15921  562 KVIEILRQQIENMTQLVGQHGRtagAMQVEKAQLEKEINDRRLELQEFKILKDKKDAK-IREL-EARVSDLELEKVKlvn 639
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1753 --AEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLD----QMRSQFQEIQDQLTATIRCTKEME 1826
Cdd:pfam15921  640 agSERLRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMEtttnKLKMQLKSAQSELEQTRNTLKSME 719
                          650       660       670
                   ....*....|....*....|....*....|...
gi 2462496564 1827 G-DTQKLEVEHVMMRKIIKKQdDQIERLEKILQ 1858
Cdd:pfam15921  720 GsDGHAMKVAMGMQKQITAKR-GQIDALQSKIQ 751
PHA03095 PHA03095
ankyrin-like protein; Provisional
44-194 8.39e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.04  E-value: 8.39e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   44 NLEKLKYLLLTYYDANKRDRKERTALHLACATGQP--EMVHLLVSRRCELNLCDREDRTPLIKAVQlrQEACATLLLQN- 120
Cdd:PHA03095   166 NVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKPraRIVRELIRAGCDPAATDMLGNTPLHSMAT--GSSCKRSLVLPl 243
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496564  121 ---GANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKVKMVEFLLKKKANVNAID 194
Cdd:PHA03095   244 liaGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVA 320
PHA03095 PHA03095
ankyrin-like protein; Provisional
32-197 8.39e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.04  E-value: 8.39e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   32 HLKRIHRAVLHGNL--------EKLKYLLLTYYDANKRDRKERTALHLacatgqpemvhlLVSRRCElnlcdredrtPLI 103
Cdd:PHA03095     6 SVDIIMEAALYDYLlnasnvtvEEVRRLLAAGADVNFRGEYGKTPLHL------------YLHYSSE----------KVK 63
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  104 KAVQLrqeacatlLLQNGANPNITDFFGRTALHYAVYNEDT-SMIEKLLSHGTNIEECSKCEYQPL--LFAVSRRKVKMV 180
Cdd:PHA03095    64 DIVRL--------LLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIKAGADVNAKDKVGRTPLhvYLSGFNINPKVI 135
                          170
                   ....*....|....*..
gi 2462496564  181 EFLLKKKANVNAIDYLG 197
Cdd:PHA03095   136 RLLLRKGADVNALDLYG 152
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1471-1826 3.24e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 58.91  E-value: 3.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1471 EIARLRLEKdtiKNQNLEKkyLKD--FEIvKRKHEDLQ---------KALKRNGETLAKTIacYSGQLAALTDENTTLRS 1539
Cdd:TIGR02168  175 KETERKLER---TRENLDR--LEDilNEL-ERQLKSLErqaekaeryKELKAELRELELAL--LVLRLEELREELEELQE 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1540 KLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQE---LAFQGTVDKC----RHLQE---NLNSHVLILSLQLS 1609
Cdd:TIGR02168  247 ELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQkelYALANEISRLeqqkQILRErlaNLERQLEELEAQLE 326
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1610 KAESKSRVLKTELHytgeALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQER-FCQLKKQNMLLQQQL 1688
Cdd:TIGR02168  327 ELESKLDELAEELA----ELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSkVAQLELQIASLNNEI 402
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1689 DDARNKADNQEKAILNIQARCDARVQNLQ-AECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVAVRQLQQKRD 1767
Cdd:TIGR02168  403 ERLEARLERLEDRRERLQQEIEELLKKLEeAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAER 482
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462496564 1768 DVLNKGSATKALLDASSRHCTYlengmQDSRKKLDQMRSQFQEIQDQLTATIRCTKEME 1826
Cdd:TIGR02168  483 ELAQLQARLDSLERLQENLEGF-----SEGVKALLKNQSGLSGILGVLSELISVDEGYE 536
Ank_4 pfam13637
Ankyrin repeats (many copies);
131-184 4.86e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 4.86e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462496564  131 GRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKVKMVEFLL 184
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1348-1712 7.41e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.76  E-value: 7.41e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1348 RVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKL-RITEEQYRIEAD 1426
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVeQLEERIAQLSKE 755
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1427 VTKPIKpalKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQ-NLEKKYLKDFEIVKRKHEDL 1505
Cdd:TIGR02168  756 LTELEA---EIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAElTLLNEEAANLRERLESLERR 832
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1506 QKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQG 1585
Cdd:TIGR02168  833 IAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSE 912
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1586 TVDKCRHLQENLNSHVlilsLQLSKAESKSRVLKTEL--HY--TGEALKEKALVFEHVQSELKQKQSQMK-DIEKMYKSG 1660
Cdd:TIGR02168  913 LRRELEELREKLAQLE----LRLEGLEVRIDNLQERLseEYslTLEEAEALENKIEDDEEEARRRLKRLEnKIKELGPVN 988
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462496564 1661 YNTMEKCIEKQERFCQLKKQnmllQQQLDDARNKAdnqEKAILNIQARCDAR 1712
Cdd:TIGR02168  989 LAAIEEYEELKERYDFLTAQ----KEDLTEAKETL---EEAIEEIDREARER 1033
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1348-1859 7.70e-08

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 57.67  E-value: 7.70e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1348 RVKIRKLKNKASVLQKRISEKE---EIKSQLKHEILE-LEKELCSLRFAIQQEKkkrrnveEVHQKVREKLRITEEQYRI 1423
Cdd:TIGR00618  186 FAKKKSLHGKAELLTLRSQLLTlctPCMPDTYHERKQvLEKELKHLREALQQTQ-------QSHAYLTQKREAQEEQLKK 258
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1424 EAdvtkpikpALKSAEVELKTGGNNSNQVSETDEKED--------LLHENRLMQDEIARLRLEKDTIKNQNLEKKYLKDF 1495
Cdd:TIGR00618  259 QQ--------LLKQLRARIEELRAQEAVLEETQERINrarkaaplAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKR 330
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1496 EIVKRKHEDLQKALKRNGETLAKTIacysgQLAALTDENTTLRSKLEKQRESRQRLETEMQSyhcrlNAARCDHDQSHSS 1575
Cdd:TIGR00618  331 AAHVKQQSSIEEQRRLLQTLHSQEI-----HIRDAHEVATSIREISCQQHTLTQHIHTLQQQ-----KTTLTQKLQSLCK 400
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1576 KRDQELAFQGTVDKCRHLQENLNSHVLIL--SLQLSKAESKSRVLKTELHYTGEALKEKALVfEHVQS--ELKQKQSQMK 1651
Cdd:TIGR00618  401 ELDILQREQATIDTRTSAFRDLQGQLAHAkkQQELQQRYAELCAAAITCTAQCEKLEKIHLQ-ESAQSlkEREQQLQTKE 479
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1652 DIEKMYKSGYNTMEKCIEK-QERFCQLKKQNMLLQQQLDDARNKADNQEK--AILNIQARCDARVQNLQAEC---RKHRL 1725
Cdd:TIGR00618  480 QIHLQETRKKAVVLARLLElQEEPCPLCGSCIHPNPARQDIDNPGPLTRRmqRGEQTYAQLETSEEDVYHQLtseRKQRA 559
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1726 LLEEDnkmlVNELNHSKEKECQYEKEKAEREVAVRQLQQKRDDVLNKGS-ATKALLDASSRHCTYLENGMQDSRKKLDQm 1804
Cdd:TIGR00618  560 SLKEQ----MQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSeAEDMLACEQHALLRKLQPEQDLQDVRLHL- 634
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496564 1805 rSQFQEIQDQLTATIrcTKEMEGDTQKLEVEHVMMRKIIKKQDDQI-ERLEKILQH 1859
Cdd:TIGR00618  635 -QQCSQELALKLTAL--HALQLTLTQERVREHALSIRVLPKELLASrQLALQKMQS 687
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1332-1653 2.09e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 56.22  E-value: 2.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1332 LWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELcslrfaiqQEKKKRRN--VEEVHQK 1409
Cdd:TIGR02168  229 LLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEI--------EELQKELYalANEISRL 300
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1410 VREKLRITEEQYRIEADvtkpikpaLKSAEVELKTGGnnsnqvSETDEKEDLLHEnrlMQDEIARLRLEKDTIKNQNLEK 1489
Cdd:TIGR02168  301 EQQKQILRERLANLERQ--------LEELEAQLEELE------SKLDELAEELAE---LEEKLEELKEELESLEAELEEL 363
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1490 KylKDFEIVKRKHEDLQKALkrngETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDH 1569
Cdd:TIGR02168  364 E--AELEELESRLEELEEQL----ETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKE 437
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1570 DQSHSSKRDQELAfqgtvdKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQS------EL 1643
Cdd:TIGR02168  438 LQAELEELEEELE------ELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGfsegvkAL 511
                          330
                   ....*....|
gi 2462496564 1644 KQKQSQMKDI 1653
Cdd:TIGR02168  512 LKNQSGLSGI 521
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1351-1836 2.56e-07

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 55.54  E-value: 2.56e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1351 IRKLKNKASVLQKRISEKEEIKSQlkhEILELEKELcslrfaiqqeKKKRRNVEEVHQKVREKLRITEEQYRIEAdvtkp 1430
Cdd:COG4717     48 LERLEKEADELFKPQGRKPELNLK---ELKELEEEL----------KEAEEKEEEYAELQEELEELEEELEELEA----- 109
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1431 ikpALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEKKYLKDfEIvKRKHEDLQKALK 1510
Cdd:COG4717    110 ---ELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELEEELEELEA-EL-AELQEELEELLE 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1511 RNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAArcdhdqshsskrdqelafqgtvDKC 1590
Cdd:COG4717    185 QLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAA----------------------ALE 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1591 RHLQENLNShVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMyksGYNTMEKCIEK 1670
Cdd:COG4717    243 ERLKEARLL-LLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEEL---QALPALEELEE 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1671 QERFCQLKKQNMLLQQQLDDARNKADNQEKAILNIQARCDARVQNLQAECRKHRL-LLEEDNKMLVNELNHSKEKECQYE 1749
Cdd:COG4717    319 EELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAaLLAEAGVEDEEELRAALEQAEEYQ 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1750 KEKAEREVAVRQLQQKRDDVLnkgsatkALLDASSRhcTYLENGMQDSRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDT 1829
Cdd:COG4717    399 ELKEELEELEEQLEELLGELE-------ELLEALDE--EELEEELEELEEELEELEEELEELREELAELEAELEQLEEDG 469

                   ....*..
gi 2462496564 1830 QKLEVEH 1836
Cdd:COG4717    470 ELAELLQ 476
PHA02874 PHA02874
ankyrin repeat protein; Provisional
36-209 4.48e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.58  E-value: 4.48e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   36 IHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACAT 115
Cdd:PHA02874   128 LHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIK 207
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  116 LLLQNGANPNITDFFGRTALHYAV-YNEdtSMIEKLLSHGTnIEECSKCEYQPLLFAVSRR-KVKMVEFLLKKKANVNAI 193
Cdd:PHA02874   208 LLIDHGNHIMNKCKNGFTPLHNAIiHNR--SAIELLINNAS-INDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIK 284
                          170
                   ....*....|....*..
gi 2462496564  194 DYLG-SIFDLIYEYERK 209
Cdd:PHA02874   285 DNKGeNPIDTAFKYINK 301
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
37-135 6.70e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 53.03  E-value: 6.70e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   37 HRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACATL 116
Cdd:COG0666    191 HLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKL 270
                           90
                   ....*....|....*....
gi 2462496564  117 LLQNGANPNITDFFGRTAL 135
Cdd:COG0666    271 LLLALLLLAAALLDLLTLL 289
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
43-192 2.61e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 52.56  E-value: 2.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   43 GNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACATLLLQ--N 120
Cdd:PLN03192   536 GNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHfaS 615
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462496564  121 GANPNItdffGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKVKMVEFLLKKKANVNA 192
Cdd:PLN03192   616 ISDPHA----AGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
Ank_5 pfam13857
Ankyrin repeats (many copies);
57-105 3.78e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.80  E-value: 3.78e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2462496564   57 DANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKA 105
Cdd:pfam13857    8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02876 PHA02876
ankyrin repeat protein; Provisional
32-197 4.05e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.99  E-value: 4.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   32 HLKRIHRAVLHGNLEKLKYLLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQE 111
Cdd:PHA02876   145 YMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNI 224
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  112 ACATLLLQNGANPNITDFfgrtALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKV-KMVEFLLKKKANV 190
Cdd:PHA02876   225 DTIKAIIDNRSNINKNDL----SLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERGADV 300

                   ....*..
gi 2462496564  191 NAIDYLG 197
Cdd:PHA02876   301 NAKNIKG 307
PHA03095 PHA03095
ankyrin-like protein; Provisional
41-234 4.65e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.18  E-value: 4.65e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   41 LHGNLEKLK---YLLLTY-YDANKRDRKERTALHL-ACATGQPEMVHLLVSRRCELNLCDREDRTPLikavqlrqEACAT 115
Cdd:PHA03095    55 LHYSSEKVKdivRLLLEAgADVNAPERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPL--------HVYLS 126
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  116 ----------LLLQNGANPNITDFFGRTALHyaVYnedtsmiekLLSHGTNIEecskceyqpllfavsrrkvkMVEFLLK 185
Cdd:PHA03095   127 gfninpkvirLLLRKGADVNALDLYGMTPLA--VL---------LKSRNANVE--------------------LLRLLID 175
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 2462496564  186 KKANVNAID-YLGSIFDLIYEYERKRYEdlpINSNPVSSQKQPALKATSG 234
Cdd:PHA03095   176 AGADVYAVDdRFRSLLHHHLQSFKPRAR---IVRELIRAGCDPAATDMLG 222
Ank_4 pfam13637
Ankyrin repeats (many copies);
65-118 5.07e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.34  E-value: 5.07e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462496564   65 ERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACATLLL 118
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00121 PTZ00121
MAEBL; Provisional
636-1107 9.07e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.91  E-value: 9.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  636 SSQKQPALKATTDEEDSVSNIA-TEIKDGEKSGTVSSQKQPALKATTDEE----DSVSNIATEIKDGE---KSGTVSSQK 707
Cdd:PTZ00121  1327 AKKKADAAKKKAEEAKKAAEAAkAEAEAAADEAEAAEEKAEAAEKKKEEAkkkaDAAKKKAEEKKKADeakKKAEEDKKK 1406
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  708 QPALKATTDEK---DSVSNIATEIKDGEKSGTVSSQKPPALTATSDEEGS-----VLSIARENKDGEKSRTVSSRKKPAL 779
Cdd:PTZ00121  1407 ADELKKAAAAKkkaDEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAkkaeeAKKKAEEAKKADEAKKKAEEAKKAD 1486
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  780 KATSDEKDSFSNITRGKKDGEISRKVSSQKPPTLKGTSDEedsvLGIARENKDGEKSRTVSSEKppglKASSAEKDSVLN 859
Cdd:PTZ00121  1487 EAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADE----AKKAEEAKKADEAKKAEEKK----KADELKKAEELK 1558
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  860 IARGKKDGEKTKRVSSRKKPSLEATSDEKDSfsnitREKKDGEISRKVSSQKPPALKGTSDEEDSVLGIARENKDGEKSR 939
Cdd:PTZ00121  1559 KAEEKKKAEEAKKAEEDKNMALRKAEEAKKA-----EEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKK 1633
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  940 TVSSEKPPGL----KATSDEKDSVLNIARGKKDGEKTRTVSSQKPPTLKATSDEEDSVLSIARENKDGEKSRTV----SS 1011
Cdd:PTZ00121  1634 KVEQLKKKEAeekkKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELkkkeAE 1713
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1012 EKPSGLKATSAEKDSVLNIARGKKYGEKTKRvssrKKPALKATSDEKDSVLYIAREKKdgEKSRTVSSPKQPALKAICDK 1091
Cdd:PTZ00121  1714 EKKKAEELKKAEEENKIKAEEAKKEAEEDKK----KAEEAKKDEEEKKKIAHLKKEEE--KKAEEIRKEKEAVIEEELDE 1787
                          490
                   ....*....|....*.
gi 2462496564 1092 EDSVPNMATEKKDEQI 1107
Cdd:PTZ00121  1788 EDEKRRMEVDKKIKDI 1803
PHA03095 PHA03095
ankyrin-like protein; Provisional
36-197 1.10e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.02  E-value: 1.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   36 IHRAVLHGNLEKLKYLLLTY-YDANKRDRKERTALHlACATGQ---PEMVHLLVSRRCELNLCDREDRTPLikAVQLRQE 111
Cdd:PHA03095    87 LHLYLYNATTLDVIKLLIKAgADVNAKDKVGRTPLH-VYLSGFninPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSR 163
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  112 ACAT----LLLQNGANPNITDFFGRTALHY---------AVYNEDT----------------------------SMIEKL 150
Cdd:PHA03095   164 NANVellrLLIDAGADVYAVDDRFRSLLHHhlqsfkpraRIVRELIragcdpaatdmlgntplhsmatgssckrSLVLPL 243
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 2462496564  151 LSHGTNIEECSKCEYQPLLFAVSRRKVKMVEFLLKKKANVNAIDYLG 197
Cdd:PHA03095   244 LIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDG 290
PTZ00121 PTZ00121
MAEBL; Provisional
1345-1757 1.79e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.14  E-value: 1.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1345 EQLRVKIRKLKNKASVLQKRISEKEEI-----KSQLKHEILELEKELCSLRFAIQQEKK--KRRNVEEVHQKVREKLRit 1417
Cdd:PTZ00121  1394 DEAKKKAEEDKKKADELKKAAAAKKKAdeakkKAEEKKKADEAKKKAEEAKKADEAKKKaeEAKKAEEAKKKAEEAKK-- 1471
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1418 EEQYRIEADVTKPIKPALKSAEvELKTGGNNSNQVSETDEKEDLLH--ENRLMQDEiarLRLEKDTIKNQNLEKKYLKDF 1495
Cdd:PTZ00121  1472 ADEAKKKAEEAKKADEAKKKAE-EAKKKADEAKKAAEAKKKADEAKkaEEAKKADE---AKKAEEAKKADEAKKAEEKKK 1547
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1496 EIVKRKHEDLQKALKRNGETLAKTiacysgqlaALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSS 1575
Cdd:PTZ00121  1548 ADELKKAEELKKAEEKKKAEEAKK---------AEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEA 1618
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1576 K-RDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIE 1654
Cdd:PTZ00121  1619 KiKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEA 1698
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1655 KMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDDARNKADNQEKAI--LNIQARCDARVQNLQAECRKHRLLLEEDNK 1732
Cdd:PTZ00121  1699 EEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAeeAKKDEEEKKKIAHLKKEEEKKAEEIRKEKE 1778
                          410       420
                   ....*....|....*....|....*
gi 2462496564 1733 MLVNELNHSKEKECQYEKEKAEREV 1757
Cdd:PTZ00121  1779 AVIEEELDEEDEKRRMEVDKKIKDI 1803
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1350-1557 2.02e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.99  E-value: 2.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1350 KIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKLRITEEQY-------- 1421
Cdd:COG4942     21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIaelraele 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1422 RIEADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHE-NRLMQDEIARLRLEKDTIKNQNlekkylKDFEIVKR 1500
Cdd:COG4942    101 AQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYlAPARREQAEELRADLAELAALR------AELEAERA 174
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496564 1501 KHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQS 1557
Cdd:COG4942    175 ELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIAR 231
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1334-1655 2.06e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 49.68  E-value: 2.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1334 KRLIKLKDNHCEQLRVKI---RKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKK----KRRNVEEV 1406
Cdd:TIGR02169  198 QQLERLRREREKAERYQAllkEKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKrleeIEQLLEEL 277
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1407 HQKVREKlrITEEQYRIEADVtkpikpalksAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQn 1486
Cdd:TIGR02169  278 NKKIKDL--GEEEQLRVKEKI----------GELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELERE- 344
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1487 lekkyLKDFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEK---QRESRQRLETEMQSYHCRLN 1563
Cdd:TIGR02169  345 -----IEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKlkrEINELKRELDRLQEELQRLS 419
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1564 AARCDHDQSHSSKRDQELAFQGTVD----KCRHLQENLNShvliLSLQLSKAESKSRVLKTELhytgealkekalvfEHV 1639
Cdd:TIGR02169  420 EELADLNAAIAGIEAKINELEEEKEdkalEIKKQEWKLEQ----LAADLSKYEQELYDLKEEY--------------DRV 481
                          330
                   ....*....|....*.
gi 2462496564 1640 QSELKQKQSQMKDIEK 1655
Cdd:TIGR02169  482 EKELSKLQRELAEAEA 497
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
1366-1869 2.49e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 49.40  E-value: 2.49e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1366 SEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTG 1445
Cdd:pfam01576   57 AEAEEMRARLAARKQELEEILHELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKL 136
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1446 GNNSNQVSETDEKedLLHENRLMQDEIARL--RLEKDTIKNQNLEKkylkdfeiVKRKHE----DLQKALKRNGET---L 1516
Cdd:pfam01576  137 EEDILLLEDQNSK--LSKERKLLEERISEFtsNLAEEEEKAKSLSK--------LKNKHEamisDLEERLKKEEKGrqeL 206
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1517 AKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQElafqgtvDKCRHLQEN 1596
Cdd:pfam01576  207 EKAKRKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELE-------AQISELQED 279
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1597 LNSHvlilSLQLSKAESKSRVLKTELhytgEALK---EKALVFEHVQSELKQKQSQMkdiekmyksgYNTMEKCIEKQER 1673
Cdd:pfam01576  280 LESE----RAARNKAEKQRRDLGEEL----EALKtelEDTLDTTAAQQELRSKREQE----------VTELKKALEEETR 341
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1674 FCQLKKQNML---------LQQQLDDARNKADNQEKAilniqarcdarvqnlqaecrkhRLLLEEDNKMLVNELNHSKEK 1744
Cdd:pfam01576  342 SHEAQLQEMRqkhtqaleeLTEQLEQAKRNKANLEKA----------------------KQALESENAELQAELRTLQQA 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1745 ECQYEKEKAEREVAVRQLQQK-------RDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLDQMRSQFQEIQDQLTA 1817
Cdd:pfam01576  400 KQDSEHKRKKLEGQLQELQARlseserqRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQE 479
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462496564 1818 TIRCTKEMEGDTQKLEVEHVMMRKIIKKQDDQIERLEKilQHSSLMLQVFES 1869
Cdd:pfam01576  480 ETRQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVER--QLSTLQAQLSDM 529
PHA02874 PHA02874
ankyrin repeat protein; Provisional
67-197 3.42e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.42  E-value: 3.42e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   67 TALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGANP---------------------- 124
Cdd:PHA02874    37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTsilpipciekdmiktildcgid 116
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496564  125 -NITDFFGRTALHYAVYNEDTSMIEKLLSHG--TNIEECSKCeyQPLLFAVSRRKVKMVEFLLKKKANVNAIDYLG 197
Cdd:PHA02874   117 vNIKDAELKTFLHYAIKKGDLESIKMLFEYGadVNIEDDNGC--YPIHIAIKHNFFDIIKLLLEKGAYANVKDNNG 190
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1345-1772 4.94e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 48.52  E-value: 4.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1345 EQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKLRITEEQYRIE 1424
Cdd:PRK03918   234 EELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELREIE 313
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1425 ADVTKpIKPALKSAEVELKTGGNNSNQVSETDEKEDLLhenrlmQDEIARLrlekdtiknqnleKKYLKDFEIVKRKHED 1504
Cdd:PRK03918   314 KRLSR-LEEEINGIEERIKELEEKEERLEELKKKLKEL------EKRLEEL-------------EERHELYEEAKAKKEE 373
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1505 LQKALKR-NGETLAKTIAcysgQLAALTDENTTLRSKLEKQRESRQRLETEMQSyhcrlnaarcdhdqshsskrdqelaf 1583
Cdd:PRK03918   374 LERLKKRlTGLTPEKLEK----ELEELEKAKEEIEEEISKITARIGELKKEIKE-------------------------- 423
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1584 qgtvdkcrhLQENLNshvlilslQLSKAESKSRVLKTEL--HYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSgy 1661
Cdd:PRK03918   424 ---------LKKAIE--------ELKKAKGKCPVCGRELteEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRE-- 484
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1662 ntMEKCIEKQERFCQLKKqnmlLQQQLDDARNKAD--NQEKailniqarcdarvqnLQAECRKHRLLLEEDNKML--VNE 1737
Cdd:PRK03918   485 --LEKVLKKESELIKLKE----LAEQLKELEEKLKkyNLEE---------------LEKKAEEYEKLKEKLIKLKgeIKS 543
                          410       420       430
                   ....*....|....*....|....*....|....*
gi 2462496564 1738 LNHSKEKECQYEKEKAEREVAVRQLQQKRDDVLNK 1772
Cdd:PRK03918   544 LKKELEKLEELKKKLAELEKKLDELEEELAELLKE 578
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
67-154 7.20e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 47.77  E-value: 7.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   67 TALHLACATGQPEMVHLLVSR------RCELNLCDREDRTPLIKAVQLR--------QEACATLLLQNGANPNITDFFGR 132
Cdd:TIGR00870  130 TALHLAAHRQNYEIVKLLLERgasvpaRACGDFFVKSQGVDSFYHGESPlnaaaclgSPSIVALLSEDPADILTADSLGN 209
                           90       100       110
                   ....*....|....*....|....*....|.
gi 2462496564  133 TALHYAVYNED---------TSMIEKLLSHG 154
Cdd:TIGR00870  210 TLLHLLVMENEfkaeyeelsCQMYNFALSLL 240
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1345-1557 8.19e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 47.62  E-value: 8.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1345 EQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKLRITEEQYRIE 1424
Cdd:COG1196    284 EEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEA 363
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1425 ADVTKpikpALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEKKYLKDFEIVKRKHED 1504
Cdd:COG1196    364 EEALL----EAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEE 439
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462496564 1505 LQKALKRNGETLAKTIAcysgQLAALTDENTTLRSKLEKQRESRQRLETEMQS 1557
Cdd:COG1196    440 EEEALEEAAEEEAELEE----EEEALLELLAELLEEAALLEAALAELLEELAE 488
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1336-1859 8.46e-05

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 47.71  E-value: 8.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1336 LIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKVRE-KL 1414
Cdd:TIGR04523  153 ELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQlKD 232
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1415 RITEEQYRIEA------DVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLhENRLMQDEIARLRLEKDtiKNQNLE 1488
Cdd:TIGR04523  233 NIEKKQQEINEktteisNTQTQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKEL-EKQLNQLKSEISDLNNQ--KEQDWN 309
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1489 KKYLKDFEIVKRKHEDLQKALKRNGET---LAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNaa 1565
Cdd:TIGR04523  310 KELKSELKNQEKKLEEIQNQISQNNKIisqLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIK-- 387
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1566 rcdhdQSHSSKRDQELAFQGTVDKCRHLQENLNShVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQ 1645
Cdd:TIGR04523  388 -----NLESQINDLESKIQNQEKLNQQKDEQIKK-LQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDN 461
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1646 KQSQMKDIEKMYKSGYNTMEKCIEKQerfcqlkkqnmllQQQLDDarnkaDNQEKAILNIQARcdarvqnlqaecrkhrl 1725
Cdd:TIGR04523  462 TRESLETQLKVLSRSINKIKQNLEQK-------------QKELKS-----KEKELKKLNEEKK----------------- 506
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1726 LLEEDNKMLVNELNHSKEKECQYEKEKAEREVAVRQLQQ---KRDDVLNKGSATKAL------LDASSRHCTYLENGMQD 1796
Cdd:TIGR04523  507 ELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDelnKDDFELKKENLEKEIdeknkeIEELKQTQKSLKKKQEE 586
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462496564 1797 SRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDTQKLEVEHVMMRKIIKKQDDQIERLEKILQH 1859
Cdd:TIGR04523  587 KQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQ 649
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1237-1765 1.10e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 47.41  E-value: 1.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1237 KMKDVqtSTPAEQDLEMASEGEQKRLEEYENNQPQVKNQIHSRDDLDDI-------IQSSQTVSEDgdsLCCNCKNVILL 1309
Cdd:pfam05483  255 KMKDL--TFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIkmslqrsMSTQKALEED---LQIATKTICQL 329
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1310 IDQHEMKCKD-----CVHLL---KIKNTFCLWKRLIKLK----DNHCEQLRVKIRKLKNKASVLQkrisEKEEIKSQLKH 1377
Cdd:pfam05483  330 TEEKEAQMEElnkakAAHSFvvtEFEATTCSLEELLRTEqqrlEKNEDQLKIITMELQKKSSELE----EMTKFKNNKEV 405
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1378 EILELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKLRITEEQYR------IEADVTKPIKPALKSAEVELKTGGNNS-- 1449
Cdd:pfam05483  406 ELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLLQAREKeihdleIQLTAIKTSEEHYLKEVEDLKTELEKEkl 485
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1450 NQVSETDEKEDLLHENRLMQDEIARLRLEkdtiknqnlekkylkdfeiVKRKHEDLQKALKRNGETLAktiacysgQLAA 1529
Cdd:pfam05483  486 KNIELTAHCDKLLLENKELTQEASDMTLE-------------------LKKHQEDIINCKKQEERMLK--------QIEN 538
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1530 LTDENTTLRSKLEKQRESRQRLETEMQsyhCRLNAARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLnshvlilslqls 1609
Cdd:pfam05483  539 LEEKEMNLRDELESVREEFIQKGDEVK---CKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQI------------ 603
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1610 kaESKSRVLKtELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLKKQNMLlqQQLD 1689
Cdd:pfam05483  604 --ENKNKNIE-ELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLL--EEVE 678
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496564 1690 DARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVAVRQLQQK 1765
Cdd:pfam05483  679 KAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQSSAKAALEIELSNIKAE 754
Ank_5 pfam13857
Ankyrin repeats (many copies);
83-138 1.46e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 1.46e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496564   83 LLVSRRCELNLCDREDRTPLIKAVQLRQEACATLLLQNGANPNITDFFGRTALHYA 138
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1332-1613 1.49e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.85  E-value: 1.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1332 LWKRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKVR 1411
Cdd:COG1196    229 LLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLE 308
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1412 EKLR-ITEEQYRIEADVTkpikpALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEKK 1490
Cdd:COG1196    309 ERRReLEERLEELEEELA-----ELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEE 383
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1491 YLKDFEIVKRKHEDLQKALKRNGETLAKTIAcysgQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHD 1570
Cdd:COG1196    384 LAEELLEALRAAAELAAQLEELEEAEEALLE----RLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEE 459
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 2462496564 1571 QSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAES 1613
Cdd:COG1196    460 ALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEAD 502
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
131-159 1.93e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 40.26  E-value: 1.93e-04
                            10        20
                    ....*....|....*....|....*....
gi 2462496564   131 GRTALHYAVYNEDTSMIEKLLSHGTNIEE 159
Cdd:smart00248    2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
51-107 2.19e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.04  E-value: 2.19e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462496564   51 LLLTYYDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDREDRTPLIKAVQ 107
Cdd:PTZ00322   101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEE 157
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
682-900 2.21e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 46.58  E-value: 2.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  682 DEEDSVSNIATEIKDGEKSGTVSS---QKQPALKATTDEKDSV-----SNIATEIKDGEKSGTVSSQKPPALTATSDEEG 753
Cdd:PTZ00108  1144 QEEVEEKEIAKEQRLKSKTKGKASklrKPKLKKKEKKKKKSSAdkskkASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGS 1223
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  754 SVLSIARENKDGEKS------RTVSSRKKPALKATSDEKDSFSNITRGKKDGEISRKVSSQKPPTLKGTSDEEDSVLGIA 827
Cdd:PTZ00108  1224 DQEDDEEQKTKPKKSsvkrlkSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPS 1303
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  828 RENKDGEKSRTVSSEKppGLKASSAEKDSVLNIARGKKD-----GEKTKRVSSRKKPSLEATS--DEKDSFSNITREKKD 900
Cdd:PTZ00108  1304 SPTKKKVKKRLEGSLA--ALKKKKKSEKKTARKKKSKTRvkqasASQSSRLLRRPRKKKSDSSseDDDDSEVDDSEDEDD 1381
Ank_5 pfam13857
Ankyrin repeats (many copies);
117-171 2.41e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.79  E-value: 2.41e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496564  117 LLQNG-ANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFA 171
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
1374-1704 2.44e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.08  E-value: 2.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1374 QLKHEILELEKELCSLRFAIQQEKKKRRNvEEVHQKVREKLRITEEQYRIEAdvtkpikpALKSAEVELKTggnnsnqvs 1453
Cdd:COG1196    217 ELKEELKELEAELLLLKLRELEAELEELE-AELEELEAELEELEAELAELEA--------ELEELRLELEE--------- 278
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1454 ETDEKEDLLHENRLMQDEIArlRLEKDTIKNQNLEKKYLKDFEIVKRKHEDLQKALKRNGETLAKTIAcysgQLAALTDE 1533
Cdd:COG1196    279 LELELEEAQAEEYELLAELA--RLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEE----ELEEAEEE 352
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1534 NTTLRSKLEKQRESRQRLETEMQsyhcrlnaarcDHDQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAES 1613
Cdd:COG1196    353 LEEAEAELAEAEEALLEAEAELA-----------EAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEE 421
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1614 KSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDIEKMYKsgyntmekciEKQERFCQLKKQNMLLQQQLDDARN 1693
Cdd:COG1196    422 ELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA----------ELLEEAALLEAALAELLEELAEAAA 491
                          330
                   ....*....|.
gi 2462496564 1694 KADNQEKAILN 1704
Cdd:COG1196    492 RLLLLLEAEAD 502
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1338-1729 4.93e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.05  E-value: 4.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1338 KLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKvREKLRIT 1417
Cdd:PRK03918   380 RLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRK-ELLEEYT 458
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1418 EEQYRIEADVtKPIKPALKSAEVELKtggnnsnQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEKKYlKDFEI 1497
Cdd:PRK03918   459 AELKRIEKEL-KEIEEKERKLRKELR-------ELEKVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKA-EEYEK 529
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1498 VKRKHEDLQKALKRNGETLAKtiacysgqLAALTDENTTLRSKLEKQRESRQRLETEMQSY--------HCRLNAARCDH 1569
Cdd:PRK03918   530 LKEKLIKLKGEIKSLKKELEK--------LEELKKKLAELEKKLDELEEELAELLKELEELgfesveelEERLKELEPFY 601
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1570 DQSHSSKrDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAES-KSRVLKTELHYTGEALKEKALVFEHVQSELKQKQS 1648
Cdd:PRK03918   602 NEYLELK-DAEKELEREEKELKKLEEELDKAFEELAETEKRLEElRKELEELEKKYSEEEYEELREEYLELSRELAGLRA 680
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1649 QMKDIEKMYKsgynTMEKCIEKQERfcQLKKqnmllqqqLDDARNKADNQEKAIlniqarcdARVQNLQAECRKHRLLLE 1728
Cdd:PRK03918   681 ELEELEKRRE----EIKKTLEKLKE--ELEE--------REKAKKELEKLEKAL--------ERVEELREKVKKYKALLK 738

                   .
gi 2462496564 1729 E 1729
Cdd:PRK03918   739 E 739
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
36-187 5.44e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 45.00  E-value: 5.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   36 IHRAVLHGNLEKLKYLLltyyDANKRDRKE---------RTALHLACATGQPEMVHLLVSRRCELN------LCDREDRT 100
Cdd:cd22192     55 LHVAALYDNLEAAVVLM----EAAPELVNEpmtsdlyqgETALHIAVVNQNLNLVRELIARGADVVspratgTFFRPGPK 130
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  101 --------PLIKAVQLRQEACATLLLQNGANPNITDFFGRTALHYAVYNEDTS----MIEKLLSHGTNIEECS------K 162
Cdd:cd22192    131 nliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTfacqMYDLILSYDKEDDLQPldlvpnN 210
                          170       180
                   ....*....|....*....|....*
gi 2462496564  163 CEYQPLLFAVSRRKVKMVEFLLKKK 187
Cdd:cd22192    211 QGLTPFKLAAKEGNIVMFQHLVQKR 235
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1340-1826 6.72e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 44.71  E-value: 6.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1340 KDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKL-RITE 1418
Cdd:pfam05483  252 KENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTIcQLTE 331
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1419 EqyrieadvtkpikpalKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQNLEkkylkdfeiV 1498
Cdd:pfam05483  332 E----------------KEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITME---------L 386
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1499 KRKHEDLQK--ALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRL-------ETEMQSYHCRLNAARCdh 1569
Cdd:pfam05483  387 QKKSSELEEmtKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQELifllqarEKEIHDLEIQLTAIKT-- 464
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1570 DQSHSSKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYtgealkekalvfEHVQSELKQKQSQ 1649
Cdd:pfam05483  465 SEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQ------------EDIINCKKQEERM 532
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1650 MKDIEkmyksgyNTMEKCIEKQERFCQLKKQnmlLQQQLDDARNKADNQEKAILNIQARCdarvqnlqaecrkhrLLLEE 1729
Cdd:pfam05483  533 LKQIE-------NLEEKEMNLRDELESVREE---FIQKGDEVKCKLDKSEENARSIEYEV---------------LKKEK 587
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1730 DNKMLVNELNHSKekecqyeKEKAEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLDQMRSQFQ 1809
Cdd:pfam05483  588 QMKILENKCNNLK-------KQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQ 660
                          490
                   ....*....|....*...
gi 2462496564 1810 -EIQDQLTATIRCTKEME 1826
Cdd:pfam05483  661 kEIEDKKISEEKLLEEVE 678
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
114-209 6.78e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 44.62  E-value: 6.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  114 ATLLLQNGA-----NPNITDFF-GRTALHYAVYNEDTSMIEKLLSHGTNI------------EECSKCEY--QPLLFAVS 173
Cdd:cd22192     66 AAVVLMEAApelvnEPMTSDLYqGETALHIAVVNQNLNLVRELIARGADVvspratgtffrpGPKNLIYYgeHPLSFAAC 145
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462496564  174 RRKVKMVEFLLKKKANVNAIDYLGS-----------------IFDLIYEYERK 209
Cdd:cd22192    146 VGNEEIVRLLIEHGADIRAQDSLGNtvlhilvlqpnktfacqMYDLILSYDKE 198
PTZ00121 PTZ00121
MAEBL; Provisional
1345-1855 7.07e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 7.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1345 EQLRVKIRKLKNKASVLQKRISEK----EEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKLRITEEQ 1420
Cdd:PTZ00121  1318 DEAKKKAEEAKKKADAAKKKAEEAkkaaEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAK 1397
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1421 YRIEADVTKpiKPALKSAEVELKTGGNNSNQVSETDEKEDLLH--ENRLMQDEIARLRLEKDTIKNQNLEKKYLKDFEIV 1498
Cdd:PTZ00121  1398 KKAEEDKKK--ADELKKAAAAKKKADEAKKKAEEKKKADEAKKkaEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEA 1475
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1499 KRKHEDLQKA--LKRNGETLAKTiacysgqlaalTDEnttLRSKLEKQRESRQRLETEmqsyhcrlNAARCDHDQSHSSK 1576
Cdd:PTZ00121  1476 KKKAEEAKKAdeAKKKAEEAKKK-----------ADE---AKKAAEAKKKADEAKKAE--------EAKKADEAKKAEEA 1533
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1577 RdqelafqgTVDKCRHLQENLNSHVLILSLQLSKAESKSrvlKTELHYTGEALKEKAL--VFEHVQSELKQKQSQMKDIE 1654
Cdd:PTZ00121  1534 K--------KADEAKKAEEKKKADELKKAEELKKAEEKK---KAEEAKKAEEDKNMALrkAEEAKKAEEARIEEVMKLYE 1602
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1655 KMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDDARNKADNQEKAilnIQARCDARVQNLQAECRKHRlllEEDNKML 1734
Cdd:PTZ00121  1603 EEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKA---EELKKAEEENKIKAAEEAKK---AEEDKKK 1676
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1735 VNELNHSKEKECQYE---KEKAEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLDQMRSqfQEI 1811
Cdd:PTZ00121  1677 AEEAKKAEEDEKKAAealKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKK--DEE 1754
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....
gi 2462496564 1812 QDQLTATIRCTKEMEGDTQKLEVEHVMMRKIIKKQDDQIERLEK 1855
Cdd:PTZ00121  1755 EKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDK 1798
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
1352-1867 8.85e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 44.44  E-value: 8.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1352 RKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQE--------KKKRRNVEEVHQKVREKLRITEEQYRI 1423
Cdd:pfam12128  265 FGYKSDETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELNGElsaadaavAKDRSELEALEDQHGAFLDADIETAAA 344
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1424 EADVTKPIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLmQDEIARLRLEKDTIKN-------------QNLEKK 1490
Cdd:pfam12128  345 DQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQN-NRDIAGIKDKLAKIREardrqlavaeddlQALESE 423
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1491 YLKDFEIVKRKHEDLQKALKRNGETLAKTI--ACYSG----QLAALTDENTTLRSKLEKQRESRQRLETEmqsyhcrLNA 1564
Cdd:pfam12128  424 LREQLEAGKLEFNEEEYRLKSRLGELKLRLnqATATPelllQLENFDERIERAREEQEAANAEVERLQSE-------LRQ 496
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1565 ARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLN--SHVLILSLQLSKA---ESKSRVLKTELhytgeaLKEKALVFEHV 1639
Cdd:pfam12128  497 ARKRRDQASEALRQASRRLEERQSALDELELQLFpqAGTLLHFLRKEAPdweQSIGKVISPEL------LHRTDLDPEVW 570
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1640 QSELKQKQSQMK---DIEKMYKSGYNTMEKciekqerfcQLKKQNMLLQQQLDDARNKADNQEKAILNIqarcDARVQNL 1716
Cdd:pfam12128  571 DGSVGGELNLYGvklDLKRIDVPEWAASEE---------ELRERLDKAEEALQSAREKQAAAEEQLVQA----NGELEKA 637
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1717 QAECRKHRLLLE---EDNKMLVNELNHSKEK-ECQYEKEKAEREVAVRQLQQKRDDVLNKGSATKA-----LLDASSRHC 1787
Cdd:pfam12128  638 SREETFARTALKnarLDLRRLFDEKQSEKDKkNKALAERKDSANERLNSLEAQLKQLDKKHQAWLEeqkeqKREARTEKQ 717
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1788 TYLENGMQDSRKKLDQMRSQFQEIQDQLTATIR-CTKEMEGDTQKLEVEHVMMRKIIKKQDDQIERLEKILQHSSLMLQV 1866
Cdd:pfam12128  718 AYWQVVEGALDAQLALLKAAIAARRSGAKAELKaLETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRRQEVLRY 797

                   .
gi 2462496564 1867 F 1867
Cdd:pfam12128  798 F 798
PHA02876 PHA02876
ankyrin repeat protein; Provisional
31-196 1.10e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 43.90  E-value: 1.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   31 YHLKRIHRAVLHGNlEKLKYLLLTY-YDANKRDRKERTALHLACATGQPEMVHLLVSRRCELNLCDredrTPLIKAVQLR 109
Cdd:PHA02876   177 YCITPIHYAAERGN-AKMVNLLLSYgADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKND----LSLLKAIRNE 251
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  110 QEACATLLLQNGANPNITDFFGRTALHYAVYNEDTS-MIEKLLSHGTNIEECSKCEYQPL-LFAVSRRKVKMVEFLLKKK 187
Cdd:PHA02876   252 DLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLyLMAKNGYDTENIRTLIMLG 331

                   ....*....
gi 2462496564  188 ANVNAIDYL 196
Cdd:PHA02876   332 ADVNAADRL 340
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
64-187 1.63e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 43.33  E-value: 1.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   64 KERTALHLACATGQPEMVHLLVSRRCELNL--CDREDRT-----------PLIKAVQLRQEACATLLLQNGANP---NIT 127
Cdd:cd21882     72 QGQTALHIAIENRNLNLVRLLVENGADVSAraTGRFFRKspgnlfyfgelPLSLAACTNQEEIVRLLLENGAQPaalEAQ 151
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462496564  128 DFFGRTALHYAVYNED---------TSMIEKLLSHGTNIEECSKCE-------YQPLLFAVSRRKVKMVEFLLKKK 187
Cdd:cd21882    152 DSLGNTVLHALVLQADntpensafvCQMYNLLLSYGAHLDPTQQLEeipnhqgLTPLKLAAVEGKIVMFQHILQRE 227
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
66-96 1.70e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.65  E-value: 1.70e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462496564   66 RTALHLACA-TGQPEMVHLLVSRRCELNLCDR 96
Cdd:pfam00023    3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
66-93 2.23e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 2.23e-03
                            10        20
                    ....*....|....*....|....*...
gi 2462496564    66 RTALHLACATGQPEMVHLLVSRRCELNL 93
Cdd:smart00248    3 RTPLHLAAENGNLEVVKLLLDKGADINA 30
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1345-1582 2.28e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 43.11  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1345 EQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKL-RITEEQYRI 1423
Cdd:PRK02224   352 DDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERdELREREAEL 431
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1424 EADVtKPIKPALKSAEVELKTGG--------NNSNQVSETDEKEDLLHEnrlMQDEIARLRLEKDTIKNQNLEKKYLKDF 1495
Cdd:PRK02224   432 EATL-RTARERVEEAEALLEAGKcpecgqpvEGSPHVETIEEDRERVEE---LEAELEDLEEEVEEVEERLERAEDLVEA 507
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1496 EIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSyhCRLNAARCDHDQSHSS 1575
Cdd:PRK02224   508 EDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEE--AREEVAELNSKLAELK 585

                   ....*..
gi 2462496564 1576 KRDQELA 1582
Cdd:PRK02224   586 ERIESLE 592
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1637-1855 2.84e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 42.75  E-value: 2.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1637 EHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDDARnKADNQEKAILNiqarcdARVQNL 1716
Cdd:TIGR02169  698 RRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEI-ENVKSELKELE------ARIEEL 770
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1717 QAECRKHRLLLEEdnkmLVNELNHSKEKECQYEKEKAEREVA-----VRQLQQKrddvLNKGSATKALLDASSRHctyLE 1791
Cdd:TIGR02169  771 EEDLHKLEEALND----LEARLSHSRIPEIQAELSKLEEEVSriearLREIEQK----LNRLTLEKEYLEKEIQE---LQ 839
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462496564 1792 NGMQDSRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDTQKLEVEHVMMRKiikkqddQIERLEK 1855
Cdd:TIGR02169  840 EQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKK-------ERDELEA 896
PHA02875 PHA02875
ankyrin repeat protein; Provisional
98-195 2.90e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.29  E-value: 2.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564   98 DRTPLIKAVQLRQEACATLLLQNGANPNITDFFGRTALHYAVYNEDTSMIEKLLSHGTNIEECSKCEYQPLLFAVSRRKV 177
Cdd:PHA02875     2 DQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDV 81
                           90
                   ....*....|....*...
gi 2462496564  178 KMVEFLLKKKANVNAIDY 195
Cdd:PHA02875    82 KAVEELLDLGKFADDVFY 99
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
131-162 3.67e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.50  E-value: 3.67e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2462496564  131 GRTALHYAVYNE-DTSMIEKLLSHGTNIEECSK 162
Cdd:pfam00023    2 GNTPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1334-1563 3.82e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 42.36  E-value: 3.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1334 KRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKELcsLRFAIQQEKKKRRNVEEVHQKVREK 1413
Cdd:TIGR02169  736 KERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARL--SHSRIPEIQAELSKLEEEVSRIEAR 813
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1414 LRiteeqyrieadvtkpikpalksaEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARLRlekDTIKNQNLEKkylk 1493
Cdd:TIGR02169  814 LR-----------------------EIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIE---KEIENLNGKK---- 863
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1494 dfEIVKRKHEDLQKALKRngetlaktiacYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLN 1563
Cdd:TIGR02169  864 --EELEEELEELEAALRD-----------LESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLS 920
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
1345-1817 3.97e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.06  E-value: 3.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1345 EQLRVKIRKLKNKASVLQKRISEKEEIK--SQLKHEILELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKlriTEEQYR 1422
Cdd:COG4717    105 EELEAELEELREELEKLEKLLQLLPLYQelEALEAELAELPERLEELEERLEELRELEEELEELEAELAEL---QEELEE 181
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1423 IEADVTKPIKPALKSAevelktggnnsnqvseTDEKEDLLHENRLMQDEIARLRLEKDTIKNQnleKKYLKDFEIVKRKH 1502
Cdd:COG4717    182 LLEQLSLATEEELQDL----------------AEELEELQQRLAELEEELEEAQEELEELEEE---LEQLENELEAAALE 242
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1503 EDLQK------------ALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRlnaarcdhd 1570
Cdd:COG4717    243 ERLKEarlllliaaallALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPAL--------- 313
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1571 qshssKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLktelhytgEALKEKALVfEHVQSELKQ--KQS 1648
Cdd:COG4717    314 -----EELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREA--------EELEEELQL-EELEQEIAAllAEA 379
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1649 QMKDIEKMYksgyntmeKCIEKQERFCQLKKQNMLLQQQLDDARNkaDNQEKAILNIQARCDARVQNLQAEcrkhrllLE 1728
Cdd:COG4717    380 GVEDEEELR--------AALEQAEEYQELKEELEELEEQLEELLG--ELEELLEALDEEELEEELEELEEE-------LE 442
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1729 EDNKMLvNELnHSKEKECQYEKEKAEREVAVRQLQQKRDDVLNK-------GSATKALLDASSRHCTYLEngmqdsRKKL 1801
Cdd:COG4717    443 ELEEEL-EEL-REELAELEAELEQLEEDGELAELLQELEELKAElrelaeeWAALKLALELLEEAREEYR------EERL 514
                          490
                   ....*....|....*.
gi 2462496564 1802 DQMRSQFQEIQDQLTA 1817
Cdd:COG4717    515 PPVLERASEYFSRLTD 530
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
1333-1862 4.83e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.93  E-value: 4.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1333 WKRLIKLKDNHCEQLRVKIRKLKN-------KASVLQKRISEKEEIKSQLKHEILELEKELCSLRFAIQQEKKKRRNVEE 1405
Cdd:TIGR04523   24 YKNIANKQDTEEKQLEKKLKTIKNelknkekELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNS 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1406 VHQKVREKLRITEEQYRIEADVTKPIKPALKSAEVELKTggNNSNQVSETDEKEDLLHENRLMQDEIARLRLEKDTIKNQ 1485
Cdd:TIGR04523  104 DLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDK--FLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKE 181
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1486 NLEKKYlkdfEIVKRKHEDLQKALK-RNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNA 1564
Cdd:TIGR04523  182 KLNIQK----NIDKIKNKLLKLELLlSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQ 257
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1565 ARCDHDQSHSSKRDQELAFQGTVDKCRHLQENLN---SHVLILSLQ------------LSKAESKSRVLKTELHYTGEAL 1629
Cdd:TIGR04523  258 LKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNqlkSEISDLNNQkeqdwnkelkseLKNQEKKLEEIQNQISQNNKII 337
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1630 KEKALVFEHVQSELKQKQSQMKDIEKMYKSGYNTMEKCIEKQErfcQLKKQNMLLQQQLDDARNKADNQEKailnIQARC 1709
Cdd:TIGR04523  338 SQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQ---SYKQEIKNLESQINDLESKIQNQEK----LNQQK 410
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1710 DARVQNLQAEcrkhRLLLEEDNKMLVNELNHSKEKECQYEKEKAEREVAVRQLQQKRDDVLNKGSATKALLDASSRHCTY 1789
Cdd:TIGR04523  411 DEQIKKLQQE----KELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQ 486
                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462496564 1790 LENGMQDSRKKLDQMRSQFQEIQDQLTATIRCTKEMEGDTQKLEVEHVMMRKIIKKQDDQIERLEKILQHSSL 1862
Cdd:TIGR04523  487 KQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENL 559
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1577-1851 6.40e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.26  E-value: 6.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1577 RDQELAFQgtVDKCRHLQEnlnshvlilsLQLSKAESKSRVlKTELhytgEALKEKALVFEHVQSELKQKQSQMKDIEKM 1656
Cdd:pfam17380  366 RQEEIAME--ISRMRELER----------LQMERQQKNERV-RQEL----EAARKVKILEEERQRKIQQQKVEMEQIRAE 428
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1657 YKSGYN-TMEKCIEKQER-FCQLKKQNMLLQQQLDDARNKADNQEKAILNiqarcdarvqnLQAECRKHRLLLEEDNKML 1734
Cdd:pfam17380  429 QEEARQrEVRRLEEERAReMERVRLEEQERQQQVERLRQQEEERKRKKLE-----------LEKEKRDRKRAEEQRRKIL 497
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1735 VNELNHSKEKECQ-------YEKEKAEREVAVRQLQQKRDdvlnkgsatkalldassrhctylengMQDSRKKLDQMRSQ 1807
Cdd:pfam17380  498 EKELEERKQAMIEeerkrklLEKEMEERQKAIYEEERRRE--------------------------AEEERRKQQEMEER 551
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 2462496564 1808 fQEIQDQltatIRCTKEMEGDTQKLEVEHVMMRKIIKKQDDQIE 1851
Cdd:pfam17380  552 -RRIQEQ----MRKATEERSRLEAMEREREMMRQIVESEKARAE 590
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1345-1859 6.41e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 41.49  E-value: 6.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1345 EQLRVKIRKLKNKASVLQKRISEKEEIKSQLK--HEILELEKELCSLRFAIQQEKKKRRNVEevHQKvreklRITEEQYR 1422
Cdd:TIGR00618  236 QQTQQSHAYLTQKREAQEEQLKKQQLLKQLRAriEELRAQEAVLEETQERINRARKAAPLAA--HIK-----AVTQIEQQ 308
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1423 IEADVTKpIKPALKSAEVELKTGGNNSNQVSETDEKEDLLHENRLMQDEIARL----RLEKDTIKNQNLEKKYLKDFEIV 1498
Cdd:TIGR00618  309 AQRIHTE-LQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAhevaTSIREISCQQHTLTQHIHTLQQQ 387
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1499 KRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDH-DQSHSSKR 1577
Cdd:TIGR00618  388 KTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQCEKLEKiHLQESAQS 467
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1578 DQELAFQGTVDKCRHLQENlNSHVLILSLQLSKAESKSRVLKTELHYTGEAlkEKALVFEHVQSELKQKQSQMKDIEKmy 1657
Cdd:TIGR00618  468 LKEREQQLQTKEQIHLQET-RKKAVVLARLLELQEEPCPLCGSCIHPNPAR--QDIDNPGPLTRRMQRGEQTYAQLET-- 542
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1658 kSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDdARNKADNQEKAILNIQARCDARVQNLQAECRKHRLLLEEDNKMLVNE 1737
Cdd:TIGR00618  543 -SEEDVYHQLTSERKQRASLKEQMQEIQQSFS-ILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRK 620
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1738 LNHSKEK------ECQYEKEKAEREVAVRQLQQK--RDDVLNKGSATKALLDASSRHCTYLENGMQDSRKKLDQMRSQFQ 1809
Cdd:TIGR00618  621 LQPEQDLqdvrlhLQQCSQELALKLTALHALQLTltQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLA 700
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2462496564 1810 EIQDQLtatiRC--TKEMEGDTQKLEVEHVMMRKI--IKKQDDQIERLEKILQH 1859
Cdd:TIGR00618  701 QCQTLL----REleTHIEEYDREFNEIENASSSLGsdLAAREDALNQSLKELMH 750
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1352-1831 8.18e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.18  E-value: 8.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1352 RKLKNKASVLQKRISEKEEIKSQLKHEIL-ELEKELCSLRFAIQQEKKKRRNVEEVHQKVREKLRITEEQyRIEADVtkp 1430
Cdd:PRK02224   180 RVLSDQRGSLDQLKAQIEEKEEKDLHERLnGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEER-REELET--- 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1431 ikpaLKSAEVELKTggnnsnQVSET-DEKEDLLHENRLMQDEIARLRLEKDTIknqnLEKKYLKDFEI--VKRKHEDLQK 1507
Cdd:PRK02224   256 ----LEAEIEDLRE------TIAETeREREELAEEVRDLRERLEELEEERDDL----LAEAGLDDADAeaVEARREELED 321
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1508 ---ALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETEMQSYHCRLNAARCDHDQSHSSKRDQELAFQ 1584
Cdd:PRK02224   322 rdeELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFG 401
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1585 GTVDKcrhlQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFE---------------HVQS-------- 1641
Cdd:PRK02224   402 DAPVD----LGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEagkcpecgqpvegspHVETieedrerv 477
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1642 -ELKQKQSQMKDIEKMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDDARNKADNQEKAIlniqARCDARVQNLQAEC 1720
Cdd:PRK02224   478 eELEAELEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEELIAERRETIEEKRERA----EELRERAAELEAEA 553
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1721 RKHRLLLE------EDNKMLVNELNhSKEKECQYEKEKAER-----------EVAVRQLQQKRDDVLNKGSATKALLDAS 1783
Cdd:PRK02224   554 EEKREAAAeaeeeaEEAREEVAELN-SKLAELKERIESLERirtllaaiadaEDEIERLREKREALAELNDERRERLAEK 632
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*....
gi 2462496564 1784 SRHCTYLENGMQDSR-KKLDQMRSQFQEIQDQLTATIRCTKEMEGDTQK 1831
Cdd:PRK02224   633 RERKRELEAEFDEARiEEAREDKERAEEYLEQVEEKLDELREERDDLQA 681
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
1334-1781 8.53e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 41.11  E-value: 8.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1334 KRLIKLKDNHCEQLRVKIRKLKNKASVLQKRISEKEEIKSQLKHEILELEKElcslrfaiQQEKKKRRNVEEVHQKVREK 1413
Cdd:pfam02463  173 EALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEE--------YLLYLDYLKLNEERIDLLQE 244
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1414 LRiTEEQYRIEADVTKPIKPALKSAEVELKTggNNSNQVSETDEKEDLLHENRLMQDEIARLRLEkdtiKNQNLEKKYLK 1493
Cdd:pfam02463  245 LL-RDEQEEIESSKQEIEKEEEKLAQVLKEN--KEEEKEKKLQEEELKLLAKEEEELKSELLKLE----RRKVDDEEKLK 317
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1494 DFEIVKRKHEDLQKALKRNGETLAKTIACYSGQLAALTDENTTLRSKLEKQRESRQRLETemqsyhcrlnaarcdhdqsh 1573
Cdd:pfam02463  318 ESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLA-------------------- 377
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1574 ssKRDQELAFQGTVDKCRHLQENLNSHVLILSLQLSKAESKSRVLKTELHYTGEALKEKALVFEHVQSELKQKQSQMKDI 1653
Cdd:pfam02463  378 --KKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEK 455
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564 1654 EKMYKSGYNTMEKCIEKQERFCQLKKQNMLLQQQLDDARNKADNQ-EKAILNIQARCDARVQNLQAECRKHRLLLEEDNK 1732
Cdd:pfam02463  456 QELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQkESKARSGLKVLLALIKDGVGGRIISAHGRLGDLG 535
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 2462496564 1733 MLVNELNHSKEKECQYEKEKAEREVAVRQLQQKRDDVLNKGSATKALLD 1781
Cdd:pfam02463  536 VAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLI 584
PRK08581 PRK08581
amidase domain-containing protein;
838-1127 9.95e-03

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 40.93  E-value: 9.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  838 TVSSEKPPGLKASSAEKDSVlniarGKKDGEKTKRVSSRKKPSLEATSDEKDSFSNITREKKD-----GEISRKVSSQKP 912
Cdd:PRK08581    30 PQKDSTAKTTSHDSKKSNDD-----ETSKDTSSKDTDKADNNNTSNQDNNDKKFSTIDSSTSDsnniiDFIYKNLPQTNI 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  913 PALKGTSDEEDSV-LGIARENKDGEKSRTVSSEKPpgLKATSDEKDSVLNIARGKKDGEKTRTVSSQKPPTLKATSDEED 991
Cdd:PRK08581   105 NQLLTKNKYDDNYsLTTLIQNLFNLNSDISDYEQP--RNSEKSTNDSNKNSDSSIKNDTDTQSSKQDKADNQKAPSSNNT 182
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462496564  992 SVLSIARENKDGEKSRTVSSEKPSGLKATSAEKDSvlniargkkygekTKRVSSRKKPALKATSDE------KDSVLYIA 1065
Cdd:PRK08581   183 KPSTSNKQPNSPKPTQPNQSNSQPASDDTANQKSS-------------SKDNQSMSDSALDSILDQysedakKTQKDYAS 249
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462496564 1066 REKKDGEKSRTVSSPKQPALKAICDKEDSVPNMATEKKDEQISGTVSCQKQPALKATSDKKD 1127
Cdd:PRK08581   250 QSKKDKTETSNTKNPQLPTQDELKHKSKPAQSFENDVNQSNTRSTSLFETGPSLSNNDDSGS 311
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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