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Conserved domains on  [gi|2462503555|ref|XP_054190335|]
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dynein axonemal heavy chain 14 isoform X12 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1527-1861 4.92e-176

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


:

Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 544.38  E-value: 4.92e-176
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1527 YGYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGKTETVKDLAKSLGKHCVVFNCFEDLDYKIVRKFFFG 1606
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1607 LVQSGAWSCFDEFNLIDLEVLSVIASQILTIKAAKDNYSARFVLEGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFR 1686
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1687 PVAMMVPHYQMIAEIILFSFGFKSANSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAGTKKREFkcdtsdslSE 1766
Cdd:pfam12774  161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSN--------PN 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1767 ADETLIVIEAIREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIYTATQQLGLQNWSSQKEKIIQFYNQLQV 1846
Cdd:pfam12774  233 LNEDVLLLRALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLV 312
                          330
                   ....*....|....*
gi 2462503555 1847 CVGVMLVGPTGGGKT 1861
Cdd:pfam12774  313 RHGVMLVGPTGSGKT 327
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
989-1394 3.56e-127

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


:

Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 407.42  E-value: 3.56e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555  989 ISDIEGDLTLRKKLWEAQEEWRQASWEWRNSSLQSIDVESVQRNVSKLMHIISVLEKGLPKSDMVTHLKQVVTEFKQELP 1068
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1069 IIIALGNPCLKPRHWEALQEIIGKSV-PLDKYCKVENLLALKIFQYENEINDMSTSATNEAALEKMLFKIIDFWNTTPLP 1147
Cdd:pfam08393   81 LIEDLRNPALRERHWKQLSEILGFDFdPLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1148 LILHHTEiySIFIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNCQRNWLYLEPVFHS 1227
Cdd:pfam08393  161 LVPYKDT--GTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFSS 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1228 SEIRRQLPAETELFSQVISMWKKIMSKIQNKQNALQITTSAGVLEILQNCNIHLEHIKKSLEDYLEVKRLIFPRFYFLSN 1307
Cdd:pfam08393  239 EDIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSN 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1308 AELLDILADSRNPESVQPHLVKCFENIKQLLIWKQDIgppAVKMlISAEGEGLVLPKKI-RVRSAVEQWLVNVEKSMFDV 1386
Cdd:pfam08393  319 DELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKE---ITGM-ISKEGEVVPFSKPPvEAKGNVEEWLNELEEEMRET 394

                   ....*...
gi 2462503555 1387 LKKFLSQG 1394
Cdd:pfam08393  395 LRDLLKEA 402
DYN1 super family cl34955
Dynein, heavy chain [Cytoskeleton];
1229-4138 2.41e-106

Dynein, heavy chain [Cytoskeleton];


The actual alignment was detected with superfamily member COG5245:

Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 384.72  E-value: 2.41e-106
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1229 EIRRQLPAETELFSQVISMWKKIMSKIQNKQNALQiTTSAGVLEILQNCNIHLEHIKKSLEDYLEVKRLIFPRFyfLSNA 1308
Cdd:COG5245    639 DLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAIN-TILEDVGDDLDLFYKEMDQVFMSIEKVLGLRWREVERA--SEVE 715
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1309 ELLDILADSRNPESVQPHLVKCFENIKQLLIWKQDIgppavKMLISAEGEGLVLPKKIRV--RSAVEQWLVNVEKSMFDV 1386
Cdd:COG5245    716 ELMDRVRELENRVYSYRFFVKKIAKEEMKTVFSSRI-----QKKEPFSLDSEAYVGFFRLyeKSIVIRGINRSMGRVLSQ 790
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1387 LKKFLSQGIEDWNCQMFsqwVLSHPGQVVLTVSQIM--FYNDCVKSFVSSYSREKLEKVHAGLMCHLEEVadlvvldtsn 1464
Cdd:COG5245    791 YLESVQEALEIEDGSFF---VSRHRVRDGGLEKGRGcdAWENCFDPPLSEYFRILEKIFPSEEGYFFDEV---------- 857
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1465 srtKAILGALLILYVHCRDIVINLLLKNIFNAEDFEWTRhLQYKWNEKQKLCYVSQGNASFTYGYEYLGCTSRLVITPLT 1544
Cdd:COG5245    858 ---LKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVS-ISELPQGLYKRFIKVRSSYRSAEMFAKNTIPFFVFEHSMD 933
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1545 DRCWLTLMEALHLNLggCPAgpAGTGKTETVKDLAKSLGKhcvvfnCFEDLDYKivRKFFFGLVQSGAWScFDEFNLIDL 1624
Cdd:COG5245    934 TSQHQKLFEAVCDEV--CRF--VDTENSRVYGMLVAGKGR------IYDGTEPR--SRIEAGPICEEERG-TEESALLDE 1000
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1625 EVLSVIASQILTIKAAKDNYSARFVLEgKEIRINMSCAVFITMNPRYgggvELPDNLKSLFRPVAMMVPhYQMIAEIilf 1704
Cdd:COG5245   1001 ISRTILVDEYLNSDEFRMLEELNSAVV-EHGLKSPSTPVEMIINERN----IVLEIGRRALDMFLSNIP-FGAIKSR--- 1071
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1705 sfgfksANSLSGKLTNLYELARKQLSQQDHYNFglRSLKIVLImagtkkrefkcDTSDSLSEADETL-IVIEAIREASLP 1783
Cdd:COG5245   1072 ------RESLDREIGAFNNEVDGIAREEDELMF--YPMFKSLK-----------AKHRMLEEKTEYLnKILSITGLPLIS 1132
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1784 KCPPEDVPLFENIiGDIFpevtvlkvNQLALEKVIYTATQQLGLQnwssqKEKIIQFYNQLQVCVGVMLVGPTGGGKT-- 1861
Cdd:COG5245   1133 DTLRERIDTLDAE-WDSF--------CRISESLKKYESQQVSGLD-----VAQFVSFLRSVDTGAFHAEYFRVFLCKIkh 1198
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1862 --TVRRILEKALTLLPIADFLSVA-ERKSASKVFKLDSSDTTETDDNIFEEIEKvvkipenhnfdwqwiildgpvdtfWV 1938
Cdd:COG5245   1199 ytDACDYLWHVKSPYVKKKYFDADmELRQFFLMFNREDMEARLADSKMEYEVER------------------------YV 1254
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1939 ENLNSVLDDTRTLCLANSERialtnkiRVIFEvdNLSqASPATVSRCAMVYMDPVDLGWEPYVKSWLLKTSKII--SQSG 2016
Cdd:COG5245   1255 EKTKAEVSSLKLELSSVGEG-------QVVVS--NLG-SIGDKVGRCLVEYDSISRLSTKGVFLDELGDTKRYLdeCLDF 1324
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2017 VDCLEFMIKNSVTDGLQFIRNRQKFQpypmEDITVVITLCRildaffdFMGKNGGFEQSDDLNDTSSKEAnsqrESVTFK 2096
Cdd:COG5245   1325 FSCFEEVQKEIDELSMVFCADALRFS----ADLYHIVKERR-------FSGVLAGSDASESLGGKSIELA----AILEHK 1389
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2097 DiekrdentwypeknpdkLTKIIQKLFVFAFTWAFGGALNREDEHRENIPFCPSLEPDSlaKVTYDFDKLVHELFGNSSQ 2176
Cdd:COG5245   1390 D-----------------LIVEMKRGINDVLKLRIFGDKCRESTPRFYLISDGDLIKDL--NERSDYEEMLIMMFNISAV 1450
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2177 VGINLPTGECSIFGYFVDIEQCEFIPWSDLVPNDqtliqrgtslltnlqrsggnflkitecgecinytatrdttclSFLM 2256
Cdd:COG5245   1451 ITNNGSIAGFELRGERVMLRKEVVIPTSDTGFVD------------------------------------------SFSN 1488
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2257 SLLLKNSCpVLLTGESGVGKTAAINQMLeklegpgafdikhgsilgdtllyseikKSSSLKQNITIlipethktatgssd 2336
Cdd:COG5245   1489 EALNTLRS-YIYCGPPGSGKEMLMCPSL---------------------------RSELITEVKYF-------------- 1526
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2337 nptkkpevrtNKKLLKNNDHKgvvVSTINFSTNvtaaktkemilkkLIRRTKDTLGAPKNN--RILIFIDDMNMPVSDMY 2414
Cdd:COG5245   1527 ----------NFSTCTMTPSK---LSVLERETE-------------YYPNTGVVRLYPKPVvkDLVLFCDEINLPYGFEY 1580
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2415 GAQPPLELIRQLLDLGGVYDTEKNTWKNIQDLSIVAACVPVV----NDISPRLLKHFSMLVLPHPSQDILCTIFQAHLGI 2490
Cdd:COG5245   1581 YPPTVIVFLRPLVERQGFWSSIAVSWVTICGIILYGACNPGTdegrVKYYERFIRKPVFVFCCYPELASLRNIYEAVLMG 1660
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2491 YFSINnftPEVQKSKDQIISCSLAIYHQVRQNMlPTPTKCHYMFNLRDMFKLLLGLLQADRTVVNSKEMAAL-LFVHEAT 2569
Cdd:COG5245   1661 SYLCF---DEFNRLSEETMSASVELYLSSKDKT-KFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPDVSLIiDWYCEAI 1736
                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2570 RVFHDRLIDFTDKSLFYRLL---------SRELENCFQIQWTQENLMNHSTVFLDFLDinkthrkkiyqntsdynkLASV 2640
Cdd:COG5245   1737 REKIDRLVQQKESSTSRQDLydfglrairEMIAGHIGEAEITFSMILFFGMACLLKKD------------------LAVF 1798
                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2641 LDEFQMKLGSISLELShsMVFFKEAIEHIIRATRVLRQPGSHMLLIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYI 2720
Cdd:COG5245   1799 VEEVRKIFGSSHLDVE--AVAYKDALLHILRSRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTG 1876
                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2721 EFKEVFKKVFIHAGLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTE-QSGHMDNRQSL 2799
Cdd:COG5245   1877 DFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFEsTSLEKDTEATL 1956
                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2800 LSFFQKRIYKNLH-IFVIMSPEGPSFRQNCRvYPSMISSCTIDWYERWPEEALLIVANSFLKEKVN----FENRENLK-- 2872
Cdd:COG5245   1957 TRVFLVYMEENLPvVFSACCSQDTSVLAGIR-SPALKNRCFIDFKKLWDTEEMSQYANSVETLSRDggrvFFINGELGvg 2035
                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2873 ------EKLAPTCVQIHKSmkdlNRKYFEETGRFYYtTPNSYLQFMETFAHILRAREEEMQTKRDRFHMGLSTILEATTL 2946
Cdd:COG5245   2036 kgalisEVFGDDAVVIEGR----GFEISMIEGSLGE-SKIKFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRG 2110
                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2947 VTEMQEELLILGPQVEQKTKETETLMEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAFDKAIV 3026
Cdd:COG5245   2111 MGELKEQLSNTVVILGVKEKNADDALSGTPGERLEREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSSKKPAVLEAVL 2190
                         1850      1860      1870      1880      1890      1900      1910      1920
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3027 ALNALDKADVAELRVYTRPPFLVLTVMNAVCILLQ-KKPNWATAKLLLSETGFLKKLINLDKD---SIPDKVFVKlKKIV 3102
Cdd:COG5245   2191 FVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLLGfEAKIWFGEQQSLRRDDFIRIIGKYPDEiefDLEARRFRE-AREC 2269
                         1930      1940      1950      1960      1970      1980      1990      2000
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3103 TLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKVVGPKQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYK 3182
Cdd:COG5245   2270 SDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYS 2349
                         2010      2020      2030      2040      2050      2060      2070      2080
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3183 DTVAEKQLLANRKTMASRRFQCASVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQLIVNKW 3262
Cdd:COG5245   2350 LDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAIEFGMS 2429
                         2090      2100      2110      2120      2130      2140      2150      2160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3263 ET-FCIENGISLSSKFSLIKVMAQKYEISRWHNQglpHGQYSVENAILIKNGQQ-WPLLIDPHRQAHKWIRQMEGSRLQK 3340
Cdd:COG5245   2430 FIrISKEFRDKEIRRRQFITEGVQKIEDFKEEAC---STDYGLENSRIRKDLQDlTAVLNDPSSKIVTSQRQMYDEKKAI 2506
                         2170      2180      2190      2200      2210      2220      2230      2240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3341 L-SIEDSNYTKKIENAMKTGGSVLLQNlLETLAPGLKAILKKDIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIENPHFL 3419
Cdd:COG5245   2507 LgSFREMEFAFGLSQARREGSDKIIGD-AEALDEEIGRLIKEEFKSNLSEVKVMINPPEIVRSTVEAVFWLSEGRSGDMG 2585
                         2250      2260      2270      2280      2290      2300      2310      2320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3420 PSVYNFVTMINFTVTFQGLQDQLLSTVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDEIVDT 3499
Cdd:COG5245   2586 SIEWKQLIQVMFVSKVLGCETEIPDALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVL 2665
                         2330      2340      2350      2360      2370      2380      2390      2400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3500 LRKSKMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMYQFSLDWFHQvfvssvvskskereh 3579
Cdd:COG5245   2666 LHNLKKSRKEIEEEESESMEIEDRIDALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSS--------------- 2730
                         2410      2420      2430      2440      2450      2460      2470      2480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3580 sfkrekvspkEVHEFisiskepnleneKNLLDKHIKSAIDMLTKSIFkvvssALFNEDKLCFSFRLctaimqnnangnli 3659
Cdd:COG5245   2731 ----------EFEKW------------RRMKSKYLCAIRYMLMSSEW-----ILDHEDRSGFIHRL-------------- 2769
                         2490      2500      2510      2520      2530      2540      2550      2560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3660 qdDIGFLPEEEwnIFLYSGILINIKS-ALSQSKLTSTFEIGESqhlqwlSDSRWRQCQYVSTHLEPFSLLCKSLLSNvSQ 3738
Cdd:COG5245   2770 --DVSFLLRTK--RFVSTLLEDKNYRqVLSSCSLYGNDVISHS------CDRFDRDVYRALKHQMDNRTHSTILTSN-SK 2838
                         2570      2580      2590      2600      2610      2620      2630      2640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3739 WDTFKNskavyslistpfssenasleentkppeetELLNENketcnpinfpWEKltsfqrlilvkvlrpeslnnsvrKFI 3818
Cdd:COG5245   2839 TNPYKE-----------------------------YTYNDS----------WAE-----------------------AFE 2856
                         2650      2660      2670      2680      2690      2700      2710      2720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3819 TEKMGNKYLQRTGVNlkdayKGSNARTPLILIQTHGIDLTNILLRfaqelkgtthhvtiisLGRDQAAKAEDLILKALTK 3898
Cdd:COG5245   2857 VEDSGDLYKFEEGLL-----ELIVGHAPLIYAHKKSLENERNVDR----------------LGSKENEVYAVLNSLFSRK 2915
                         2730      2740      2750      2760      2770      2780      2790      2800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3899 TQQWVFLQNCHLATSFMPRLC-TIVESFNSPNVTIDPEfRLWLSSKSYSSFPIPVLkkglkIAVESpqgLKSNLLQTFGC 3977
Cdd:COG5245   2916 EKSWFEVYNISLSFGWFKRYVeDVVYPIKASRVCGKVK-NMWTSMVDADMLPIQLL-----IAIDS---FVSSTYPETGC 2986
                         2810      2820      2830      2840      2850      2860      2870      2880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3978 TGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSDLGVAIKVLENSL-RGQP-SISWQAL 4055
Cdd:COG5245   2987 GYADLVEIDRYPFDYTLVIACDDAFYLSWEHAAVASVISAGPKENNEEIYFGDKDFEFKTHLLKNILfLNHLnARKWGNN 3066
                         2890      2900      2910      2920      2930      2940      2950      2960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 4056 RYLIGEVIYGGRVIDNWDKRclktLLYKFCNPEVLKDDFSFSSDGICLPVPGSASIKDY-------IHIIQSLPDDDLPE 4128
Cdd:COG5245   3067 RDLIFTIVYGKKHSLMEDSK----VVDKYCRGYGAHETSSQILASVPGGDPELVKFHMEemcrssaFGVIGQLPDLALCA 3142
                         2970
                   ....*....|
gi 2462503555 4129 VLGIHPEAIR 4138
Cdd:COG5245   3143 WLMGPCDSEY 3152
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4143-4540 5.42e-97

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


:

Pssm-ID: 465677  Cd Length: 301  Bit Score: 316.48  E-value: 5.42e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 4143 TQGEKFIENLIAMQPKTTTANlmIRPEQSKDELVMEILSDLLKRLPLTVEKEEIAVGTPstlksmmsssiweslsknLKD 4222
Cdd:pfam18199    2 NETNELLSTLLSLQPRSDSGG--GGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKYP------------------VGY 61
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 4223 HDPLIhcvllTFLKQEIKRFDKLLFVIHKSLKDLQLAIKGEIILTQELEEIFNSFLNMRVPTLWQKHAYRSCKPLSSWID 4302
Cdd:pfam18199   62 EDPLN-----TVLLQEIERFNKLLKVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIR 136
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 4303 DLIQRLNFFNTWAKvaytaiqrrymrfvtvwkqsipstsqkckhpedsennfFEGFPSRYWLPAFFFPQAFLAAVLQDYG 4382
Cdd:pfam18199  137 DLLERLKQLQDWLD--------------------------------------DEGPPKVFWLSGFFFPQAFLTAVLQNYA 178
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 4383 RSRGIAVDALTFTHHVISNTTDKDEKfsvfmpkklnivrrafkgsASSHTGVYIFGLFIEGARWNREQKILEDSLPLEMC 4462
Cdd:pfam18199  179 RKNGWPIDKLSFDFEVTKKVSPEEVT-------------------EPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELF 239
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462503555 4463 CDFPDIYFLPTKISTKtpnasnQTDSELYafECPVYQTPERSRilattglpTNFLTSVYLSTKKPPSHWITMRVALLC 4540
Cdd:pfam18199  240 SPLPVIHLKPVESDKK------KLDENTY--ECPVYKTSERHS--------TNFVFSVDLPTDKPPDHWILRGVALLL 301
 
Name Accession Description Interval E-value
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1527-1861 4.92e-176

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 544.38  E-value: 4.92e-176
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1527 YGYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGKTETVKDLAKSLGKHCVVFNCFEDLDYKIVRKFFFG 1606
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1607 LVQSGAWSCFDEFNLIDLEVLSVIASQILTIKAAKDNYSARFVLEGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFR 1686
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1687 PVAMMVPHYQMIAEIILFSFGFKSANSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAGTKKREFkcdtsdslSE 1766
Cdd:pfam12774  161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSN--------PN 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1767 ADETLIVIEAIREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIYTATQQLGLQNWSSQKEKIIQFYNQLQV 1846
Cdd:pfam12774  233 LNEDVLLLRALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLV 312
                          330
                   ....*....|....*
gi 2462503555 1847 CVGVMLVGPTGGGKT 1861
Cdd:pfam12774  313 RHGVMLVGPTGSGKT 327
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
989-1394 3.56e-127

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 407.42  E-value: 3.56e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555  989 ISDIEGDLTLRKKLWEAQEEWRQASWEWRNSSLQSIDVESVQRNVSKLMHIISVLEKGLPKSDMVTHLKQVVTEFKQELP 1068
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1069 IIIALGNPCLKPRHWEALQEIIGKSV-PLDKYCKVENLLALKIFQYENEINDMSTSATNEAALEKMLFKIIDFWNTTPLP 1147
Cdd:pfam08393   81 LIEDLRNPALRERHWKQLSEILGFDFdPLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1148 LILHHTEiySIFIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNCQRNWLYLEPVFHS 1227
Cdd:pfam08393  161 LVPYKDT--GTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFSS 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1228 SEIRRQLPAETELFSQVISMWKKIMSKIQNKQNALQITTSAGVLEILQNCNIHLEHIKKSLEDYLEVKRLIFPRFYFLSN 1307
Cdd:pfam08393  239 EDIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSN 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1308 AELLDILADSRNPESVQPHLVKCFENIKQLLIWKQDIgppAVKMlISAEGEGLVLPKKI-RVRSAVEQWLVNVEKSMFDV 1386
Cdd:pfam08393  319 DELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKE---ITGM-ISKEGEVVPFSKPPvEAKGNVEEWLNELEEEMRET 394

                   ....*...
gi 2462503555 1387 LKKFLSQG 1394
Cdd:pfam08393  395 LRDLLKEA 402
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
1229-4138 2.41e-106

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 384.72  E-value: 2.41e-106
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1229 EIRRQLPAETELFSQVISMWKKIMSKIQNKQNALQiTTSAGVLEILQNCNIHLEHIKKSLEDYLEVKRLIFPRFyfLSNA 1308
Cdd:COG5245    639 DLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAIN-TILEDVGDDLDLFYKEMDQVFMSIEKVLGLRWREVERA--SEVE 715
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1309 ELLDILADSRNPESVQPHLVKCFENIKQLLIWKQDIgppavKMLISAEGEGLVLPKKIRV--RSAVEQWLVNVEKSMFDV 1386
Cdd:COG5245    716 ELMDRVRELENRVYSYRFFVKKIAKEEMKTVFSSRI-----QKKEPFSLDSEAYVGFFRLyeKSIVIRGINRSMGRVLSQ 790
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1387 LKKFLSQGIEDWNCQMFsqwVLSHPGQVVLTVSQIM--FYNDCVKSFVSSYSREKLEKVHAGLMCHLEEVadlvvldtsn 1464
Cdd:COG5245    791 YLESVQEALEIEDGSFF---VSRHRVRDGGLEKGRGcdAWENCFDPPLSEYFRILEKIFPSEEGYFFDEV---------- 857
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1465 srtKAILGALLILYVHCRDIVINLLLKNIFNAEDFEWTRhLQYKWNEKQKLCYVSQGNASFTYGYEYLGCTSRLVITPLT 1544
Cdd:COG5245    858 ---LKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVS-ISELPQGLYKRFIKVRSSYRSAEMFAKNTIPFFVFEHSMD 933
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1545 DRCWLTLMEALHLNLggCPAgpAGTGKTETVKDLAKSLGKhcvvfnCFEDLDYKivRKFFFGLVQSGAWScFDEFNLIDL 1624
Cdd:COG5245    934 TSQHQKLFEAVCDEV--CRF--VDTENSRVYGMLVAGKGR------IYDGTEPR--SRIEAGPICEEERG-TEESALLDE 1000
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1625 EVLSVIASQILTIKAAKDNYSARFVLEgKEIRINMSCAVFITMNPRYgggvELPDNLKSLFRPVAMMVPhYQMIAEIilf 1704
Cdd:COG5245   1001 ISRTILVDEYLNSDEFRMLEELNSAVV-EHGLKSPSTPVEMIINERN----IVLEIGRRALDMFLSNIP-FGAIKSR--- 1071
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1705 sfgfksANSLSGKLTNLYELARKQLSQQDHYNFglRSLKIVLImagtkkrefkcDTSDSLSEADETL-IVIEAIREASLP 1783
Cdd:COG5245   1072 ------RESLDREIGAFNNEVDGIAREEDELMF--YPMFKSLK-----------AKHRMLEEKTEYLnKILSITGLPLIS 1132
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1784 KCPPEDVPLFENIiGDIFpevtvlkvNQLALEKVIYTATQQLGLQnwssqKEKIIQFYNQLQVCVGVMLVGPTGGGKT-- 1861
Cdd:COG5245   1133 DTLRERIDTLDAE-WDSF--------CRISESLKKYESQQVSGLD-----VAQFVSFLRSVDTGAFHAEYFRVFLCKIkh 1198
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1862 --TVRRILEKALTLLPIADFLSVA-ERKSASKVFKLDSSDTTETDDNIFEEIEKvvkipenhnfdwqwiildgpvdtfWV 1938
Cdd:COG5245   1199 ytDACDYLWHVKSPYVKKKYFDADmELRQFFLMFNREDMEARLADSKMEYEVER------------------------YV 1254
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1939 ENLNSVLDDTRTLCLANSERialtnkiRVIFEvdNLSqASPATVSRCAMVYMDPVDLGWEPYVKSWLLKTSKII--SQSG 2016
Cdd:COG5245   1255 EKTKAEVSSLKLELSSVGEG-------QVVVS--NLG-SIGDKVGRCLVEYDSISRLSTKGVFLDELGDTKRYLdeCLDF 1324
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2017 VDCLEFMIKNSVTDGLQFIRNRQKFQpypmEDITVVITLCRildaffdFMGKNGGFEQSDDLNDTSSKEAnsqrESVTFK 2096
Cdd:COG5245   1325 FSCFEEVQKEIDELSMVFCADALRFS----ADLYHIVKERR-------FSGVLAGSDASESLGGKSIELA----AILEHK 1389
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2097 DiekrdentwypeknpdkLTKIIQKLFVFAFTWAFGGALNREDEHRENIPFCPSLEPDSlaKVTYDFDKLVHELFGNSSQ 2176
Cdd:COG5245   1390 D-----------------LIVEMKRGINDVLKLRIFGDKCRESTPRFYLISDGDLIKDL--NERSDYEEMLIMMFNISAV 1450
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2177 VGINLPTGECSIFGYFVDIEQCEFIPWSDLVPNDqtliqrgtslltnlqrsggnflkitecgecinytatrdttclSFLM 2256
Cdd:COG5245   1451 ITNNGSIAGFELRGERVMLRKEVVIPTSDTGFVD------------------------------------------SFSN 1488
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2257 SLLLKNSCpVLLTGESGVGKTAAINQMLeklegpgafdikhgsilgdtllyseikKSSSLKQNITIlipethktatgssd 2336
Cdd:COG5245   1489 EALNTLRS-YIYCGPPGSGKEMLMCPSL---------------------------RSELITEVKYF-------------- 1526
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2337 nptkkpevrtNKKLLKNNDHKgvvVSTINFSTNvtaaktkemilkkLIRRTKDTLGAPKNN--RILIFIDDMNMPVSDMY 2414
Cdd:COG5245   1527 ----------NFSTCTMTPSK---LSVLERETE-------------YYPNTGVVRLYPKPVvkDLVLFCDEINLPYGFEY 1580
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2415 GAQPPLELIRQLLDLGGVYDTEKNTWKNIQDLSIVAACVPVV----NDISPRLLKHFSMLVLPHPSQDILCTIFQAHLGI 2490
Cdd:COG5245   1581 YPPTVIVFLRPLVERQGFWSSIAVSWVTICGIILYGACNPGTdegrVKYYERFIRKPVFVFCCYPELASLRNIYEAVLMG 1660
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2491 YFSINnftPEVQKSKDQIISCSLAIYHQVRQNMlPTPTKCHYMFNLRDMFKLLLGLLQADRTVVNSKEMAAL-LFVHEAT 2569
Cdd:COG5245   1661 SYLCF---DEFNRLSEETMSASVELYLSSKDKT-KFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPDVSLIiDWYCEAI 1736
                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2570 RVFHDRLIDFTDKSLFYRLL---------SRELENCFQIQWTQENLMNHSTVFLDFLDinkthrkkiyqntsdynkLASV 2640
Cdd:COG5245   1737 REKIDRLVQQKESSTSRQDLydfglrairEMIAGHIGEAEITFSMILFFGMACLLKKD------------------LAVF 1798
                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2641 LDEFQMKLGSISLELShsMVFFKEAIEHIIRATRVLRQPGSHMLLIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYI 2720
Cdd:COG5245   1799 VEEVRKIFGSSHLDVE--AVAYKDALLHILRSRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTG 1876
                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2721 EFKEVFKKVFIHAGLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTE-QSGHMDNRQSL 2799
Cdd:COG5245   1877 DFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFEsTSLEKDTEATL 1956
                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2800 LSFFQKRIYKNLH-IFVIMSPEGPSFRQNCRvYPSMISSCTIDWYERWPEEALLIVANSFLKEKVN----FENRENLK-- 2872
Cdd:COG5245   1957 TRVFLVYMEENLPvVFSACCSQDTSVLAGIR-SPALKNRCFIDFKKLWDTEEMSQYANSVETLSRDggrvFFINGELGvg 2035
                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2873 ------EKLAPTCVQIHKSmkdlNRKYFEETGRFYYtTPNSYLQFMETFAHILRAREEEMQTKRDRFHMGLSTILEATTL 2946
Cdd:COG5245   2036 kgalisEVFGDDAVVIEGR----GFEISMIEGSLGE-SKIKFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRG 2110
                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2947 VTEMQEELLILGPQVEQKTKETETLMEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAFDKAIV 3026
Cdd:COG5245   2111 MGELKEQLSNTVVILGVKEKNADDALSGTPGERLEREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSSKKPAVLEAVL 2190
                         1850      1860      1870      1880      1890      1900      1910      1920
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3027 ALNALDKADVAELRVYTRPPFLVLTVMNAVCILLQ-KKPNWATAKLLLSETGFLKKLINLDKD---SIPDKVFVKlKKIV 3102
Cdd:COG5245   2191 FVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLLGfEAKIWFGEQQSLRRDDFIRIIGKYPDEiefDLEARRFRE-AREC 2269
                         1930      1940      1950      1960      1970      1980      1990      2000
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3103 TLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKVVGPKQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYK 3182
Cdd:COG5245   2270 SDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYS 2349
                         2010      2020      2030      2040      2050      2060      2070      2080
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3183 DTVAEKQLLANRKTMASRRFQCASVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQLIVNKW 3262
Cdd:COG5245   2350 LDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAIEFGMS 2429
                         2090      2100      2110      2120      2130      2140      2150      2160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3263 ET-FCIENGISLSSKFSLIKVMAQKYEISRWHNQglpHGQYSVENAILIKNGQQ-WPLLIDPHRQAHKWIRQMEGSRLQK 3340
Cdd:COG5245   2430 FIrISKEFRDKEIRRRQFITEGVQKIEDFKEEAC---STDYGLENSRIRKDLQDlTAVLNDPSSKIVTSQRQMYDEKKAI 2506
                         2170      2180      2190      2200      2210      2220      2230      2240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3341 L-SIEDSNYTKKIENAMKTGGSVLLQNlLETLAPGLKAILKKDIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIENPHFL 3419
Cdd:COG5245   2507 LgSFREMEFAFGLSQARREGSDKIIGD-AEALDEEIGRLIKEEFKSNLSEVKVMINPPEIVRSTVEAVFWLSEGRSGDMG 2585
                         2250      2260      2270      2280      2290      2300      2310      2320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3420 PSVYNFVTMINFTVTFQGLQDQLLSTVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDEIVDT 3499
Cdd:COG5245   2586 SIEWKQLIQVMFVSKVLGCETEIPDALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVL 2665
                         2330      2340      2350      2360      2370      2380      2390      2400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3500 LRKSKMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMYQFSLDWFHQvfvssvvskskereh 3579
Cdd:COG5245   2666 LHNLKKSRKEIEEEESESMEIEDRIDALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSS--------------- 2730
                         2410      2420      2430      2440      2450      2460      2470      2480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3580 sfkrekvspkEVHEFisiskepnleneKNLLDKHIKSAIDMLTKSIFkvvssALFNEDKLCFSFRLctaimqnnangnli 3659
Cdd:COG5245   2731 ----------EFEKW------------RRMKSKYLCAIRYMLMSSEW-----ILDHEDRSGFIHRL-------------- 2769
                         2490      2500      2510      2520      2530      2540      2550      2560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3660 qdDIGFLPEEEwnIFLYSGILINIKS-ALSQSKLTSTFEIGESqhlqwlSDSRWRQCQYVSTHLEPFSLLCKSLLSNvSQ 3738
Cdd:COG5245   2770 --DVSFLLRTK--RFVSTLLEDKNYRqVLSSCSLYGNDVISHS------CDRFDRDVYRALKHQMDNRTHSTILTSN-SK 2838
                         2570      2580      2590      2600      2610      2620      2630      2640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3739 WDTFKNskavyslistpfssenasleentkppeetELLNENketcnpinfpWEKltsfqrlilvkvlrpeslnnsvrKFI 3818
Cdd:COG5245   2839 TNPYKE-----------------------------YTYNDS----------WAE-----------------------AFE 2856
                         2650      2660      2670      2680      2690      2700      2710      2720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3819 TEKMGNKYLQRTGVNlkdayKGSNARTPLILIQTHGIDLTNILLRfaqelkgtthhvtiisLGRDQAAKAEDLILKALTK 3898
Cdd:COG5245   2857 VEDSGDLYKFEEGLL-----ELIVGHAPLIYAHKKSLENERNVDR----------------LGSKENEVYAVLNSLFSRK 2915
                         2730      2740      2750      2760      2770      2780      2790      2800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3899 TQQWVFLQNCHLATSFMPRLC-TIVESFNSPNVTIDPEfRLWLSSKSYSSFPIPVLkkglkIAVESpqgLKSNLLQTFGC 3977
Cdd:COG5245   2916 EKSWFEVYNISLSFGWFKRYVeDVVYPIKASRVCGKVK-NMWTSMVDADMLPIQLL-----IAIDS---FVSSTYPETGC 2986
                         2810      2820      2830      2840      2850      2860      2870      2880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3978 TGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSDLGVAIKVLENSL-RGQP-SISWQAL 4055
Cdd:COG5245   2987 GYADLVEIDRYPFDYTLVIACDDAFYLSWEHAAVASVISAGPKENNEEIYFGDKDFEFKTHLLKNILfLNHLnARKWGNN 3066
                         2890      2900      2910      2920      2930      2940      2950      2960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 4056 RYLIGEVIYGGRVIDNWDKRclktLLYKFCNPEVLKDDFSFSSDGICLPVPGSASIKDY-------IHIIQSLPDDDLPE 4128
Cdd:COG5245   3067 RDLIFTIVYGKKHSLMEDSK----VVDKYCRGYGAHETSSQILASVPGGDPELVKFHMEemcrssaFGVIGQLPDLALCA 3142
                         2970
                   ....*....|
gi 2462503555 4129 VLGIHPEAIR 4138
Cdd:COG5245   3143 WLMGPCDSEY 3152
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4143-4540 5.42e-97

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


Pssm-ID: 465677  Cd Length: 301  Bit Score: 316.48  E-value: 5.42e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 4143 TQGEKFIENLIAMQPKTTTANlmIRPEQSKDELVMEILSDLLKRLPLTVEKEEIAVGTPstlksmmsssiweslsknLKD 4222
Cdd:pfam18199    2 NETNELLSTLLSLQPRSDSGG--GGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKYP------------------VGY 61
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 4223 HDPLIhcvllTFLKQEIKRFDKLLFVIHKSLKDLQLAIKGEIILTQELEEIFNSFLNMRVPTLWQKHAYRSCKPLSSWID 4302
Cdd:pfam18199   62 EDPLN-----TVLLQEIERFNKLLKVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIR 136
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 4303 DLIQRLNFFNTWAKvaytaiqrrymrfvtvwkqsipstsqkckhpedsennfFEGFPSRYWLPAFFFPQAFLAAVLQDYG 4382
Cdd:pfam18199  137 DLLERLKQLQDWLD--------------------------------------DEGPPKVFWLSGFFFPQAFLTAVLQNYA 178
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 4383 RSRGIAVDALTFTHHVISNTTDKDEKfsvfmpkklnivrrafkgsASSHTGVYIFGLFIEGARWNREQKILEDSLPLEMC 4462
Cdd:pfam18199  179 RKNGWPIDKLSFDFEVTKKVSPEEVT-------------------EPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELF 239
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462503555 4463 CDFPDIYFLPTKISTKtpnasnQTDSELYafECPVYQTPERSRilattglpTNFLTSVYLSTKKPPSHWITMRVALLC 4540
Cdd:pfam18199  240 SPLPVIHLKPVESDKK------KLDENTY--ECPVYKTSERHS--------TNFVFSVDLPTDKPPDHWILRGVALLL 301
AAA_9 pfam12781
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ...
3290-3510 2.20e-91

ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.


Pssm-ID: 463702 [Multi-domain]  Cd Length: 222  Bit Score: 297.05  E-value: 2.20e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3290 SRWHNQGLPHGQYSVENAILIKNGQQWPLLIDPHRQAHKWIRQMEGSR-LQKLSIEDSNYTKKIENAMKTGGSVLLQNLL 3368
Cdd:pfam12781    1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDNgLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3369 ETLAPGLKAILKKDIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIENPHFLPSVYNFVTMINFTVTFQGLQDQLLSTVVT 3448
Cdd:pfam12781   81 EELDPILDPVLLKEIFKGGGRKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462503555 3449 HEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDEIVDTLRKSKMTSNEI 3510
Cdd:pfam12781  161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
 
Name Accession Description Interval E-value
AAA_6 pfam12774
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ...
1527-1861 4.92e-176

Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.


Pssm-ID: 463697 [Multi-domain]  Cd Length: 327  Bit Score: 544.38  E-value: 4.92e-176
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1527 YGYEYLGCTSRLVITPLTDRCWLTLMEALHLNLGGCPAGPAGTGKTETVKDLAKSLGKHCVVFNCFEDLDYKIVRKFFFG 1606
Cdd:pfam12774    1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1607 LVQSGAWSCFDEFNLIDLEVLSVIASQILTIKAAKDNYSARFVLEGKEIRINMSCAVFITMNPRYGGGVELPDNLKSLFR 1686
Cdd:pfam12774   81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1687 PVAMMVPHYQMIAEIILFSFGFKSANSLSGKLTNLYELARKQLSQQDHYNFGLRSLKIVLIMAGTKKREFkcdtsdslSE 1766
Cdd:pfam12774  161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSN--------PN 232
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1767 ADETLIVIEAIREASLPKCPPEDVPLFENIIGDIFPEVTVLKVNQLALEKVIYTATQQLGLQNWSSQKEKIIQFYNQLQV 1846
Cdd:pfam12774  233 LNEDVLLLRALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLV 312
                          330
                   ....*....|....*
gi 2462503555 1847 CVGVMLVGPTGGGKT 1861
Cdd:pfam12774  313 RHGVMLVGPTGSGKT 327
DHC_N2 pfam08393
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ...
989-1394 3.56e-127

Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.


Pssm-ID: 462462 [Multi-domain]  Cd Length: 402  Bit Score: 407.42  E-value: 3.56e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555  989 ISDIEGDLTLRKKLWEAQEEWRQASWEWRNSSLQSIDVESVQRNVSKLMHIISVLEKGLPKSDMVTHLKQVVTEFKQELP 1068
Cdd:pfam08393    1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1069 IIIALGNPCLKPRHWEALQEIIGKSV-PLDKYCKVENLLALKIFQYENEINDMSTSATNEAALEKMLFKIIDFWNTTPLP 1147
Cdd:pfam08393   81 LIEDLRNPALRERHWKQLSEILGFDFdPLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1148 LILHHTEiySIFIIPSIDDISAQLEESQVILATIKGSPHIGPIKDLVNEWDQNLTLFSYTLEEWMNCQRNWLYLEPVFHS 1227
Cdd:pfam08393  161 LVPYKDT--GTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFSS 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1228 SEIRRQLPAETELFSQVISMWKKIMSKIQNKQNALQITTSAGVLEILQNCNIHLEHIKKSLEDYLEVKRLIFPRFYFLSN 1307
Cdd:pfam08393  239 EDIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSN 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1308 AELLDILADSRNPESVQPHLVKCFENIKQLLIWKQDIgppAVKMlISAEGEGLVLPKKI-RVRSAVEQWLVNVEKSMFDV 1386
Cdd:pfam08393  319 DELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKE---ITGM-ISKEGEVVPFSKPPvEAKGNVEEWLNELEEEMRET 394

                   ....*...
gi 2462503555 1387 LKKFLSQG 1394
Cdd:pfam08393  395 LRDLLKEA 402
DYN1 COG5245
Dynein, heavy chain [Cytoskeleton];
1229-4138 2.41e-106

Dynein, heavy chain [Cytoskeleton];


Pssm-ID: 227570 [Multi-domain]  Cd Length: 3164  Bit Score: 384.72  E-value: 2.41e-106
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1229 EIRRQLPAETELFSQVISMWKKIMSKIQNKQNALQiTTSAGVLEILQNCNIHLEHIKKSLEDYLEVKRLIFPRFyfLSNA 1308
Cdd:COG5245    639 DLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAIN-TILEDVGDDLDLFYKEMDQVFMSIEKVLGLRWREVERA--SEVE 715
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1309 ELLDILADSRNPESVQPHLVKCFENIKQLLIWKQDIgppavKMLISAEGEGLVLPKKIRV--RSAVEQWLVNVEKSMFDV 1386
Cdd:COG5245    716 ELMDRVRELENRVYSYRFFVKKIAKEEMKTVFSSRI-----QKKEPFSLDSEAYVGFFRLyeKSIVIRGINRSMGRVLSQ 790
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1387 LKKFLSQGIEDWNCQMFsqwVLSHPGQVVLTVSQIM--FYNDCVKSFVSSYSREKLEKVHAGLMCHLEEVadlvvldtsn 1464
Cdd:COG5245    791 YLESVQEALEIEDGSFF---VSRHRVRDGGLEKGRGcdAWENCFDPPLSEYFRILEKIFPSEEGYFFDEV---------- 857
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1465 srtKAILGALLILYVHCRDIVINLLLKNIFNAEDFEWTRhLQYKWNEKQKLCYVSQGNASFTYGYEYLGCTSRLVITPLT 1544
Cdd:COG5245    858 ---LKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVS-ISELPQGLYKRFIKVRSSYRSAEMFAKNTIPFFVFEHSMD 933
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1545 DRCWLTLMEALHLNLggCPAgpAGTGKTETVKDLAKSLGKhcvvfnCFEDLDYKivRKFFFGLVQSGAWScFDEFNLIDL 1624
Cdd:COG5245    934 TSQHQKLFEAVCDEV--CRF--VDTENSRVYGMLVAGKGR------IYDGTEPR--SRIEAGPICEEERG-TEESALLDE 1000
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1625 EVLSVIASQILTIKAAKDNYSARFVLEgKEIRINMSCAVFITMNPRYgggvELPDNLKSLFRPVAMMVPhYQMIAEIilf 1704
Cdd:COG5245   1001 ISRTILVDEYLNSDEFRMLEELNSAVV-EHGLKSPSTPVEMIINERN----IVLEIGRRALDMFLSNIP-FGAIKSR--- 1071
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1705 sfgfksANSLSGKLTNLYELARKQLSQQDHYNFglRSLKIVLImagtkkrefkcDTSDSLSEADETL-IVIEAIREASLP 1783
Cdd:COG5245   1072 ------RESLDREIGAFNNEVDGIAREEDELMF--YPMFKSLK-----------AKHRMLEEKTEYLnKILSITGLPLIS 1132
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1784 KCPPEDVPLFENIiGDIFpevtvlkvNQLALEKVIYTATQQLGLQnwssqKEKIIQFYNQLQVCVGVMLVGPTGGGKT-- 1861
Cdd:COG5245   1133 DTLRERIDTLDAE-WDSF--------CRISESLKKYESQQVSGLD-----VAQFVSFLRSVDTGAFHAEYFRVFLCKIkh 1198
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1862 --TVRRILEKALTLLPIADFLSVA-ERKSASKVFKLDSSDTTETDDNIFEEIEKvvkipenhnfdwqwiildgpvdtfWV 1938
Cdd:COG5245   1199 ytDACDYLWHVKSPYVKKKYFDADmELRQFFLMFNREDMEARLADSKMEYEVER------------------------YV 1254
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1939 ENLNSVLDDTRTLCLANSERialtnkiRVIFEvdNLSqASPATVSRCAMVYMDPVDLGWEPYVKSWLLKTSKII--SQSG 2016
Cdd:COG5245   1255 EKTKAEVSSLKLELSSVGEG-------QVVVS--NLG-SIGDKVGRCLVEYDSISRLSTKGVFLDELGDTKRYLdeCLDF 1324
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2017 VDCLEFMIKNSVTDGLQFIRNRQKFQpypmEDITVVITLCRildaffdFMGKNGGFEQSDDLNDTSSKEAnsqrESVTFK 2096
Cdd:COG5245   1325 FSCFEEVQKEIDELSMVFCADALRFS----ADLYHIVKERR-------FSGVLAGSDASESLGGKSIELA----AILEHK 1389
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2097 DiekrdentwypeknpdkLTKIIQKLFVFAFTWAFGGALNREDEHRENIPFCPSLEPDSlaKVTYDFDKLVHELFGNSSQ 2176
Cdd:COG5245   1390 D-----------------LIVEMKRGINDVLKLRIFGDKCRESTPRFYLISDGDLIKDL--NERSDYEEMLIMMFNISAV 1450
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2177 VGINLPTGECSIFGYFVDIEQCEFIPWSDLVPNDqtliqrgtslltnlqrsggnflkitecgecinytatrdttclSFLM 2256
Cdd:COG5245   1451 ITNNGSIAGFELRGERVMLRKEVVIPTSDTGFVD------------------------------------------SFSN 1488
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2257 SLLLKNSCpVLLTGESGVGKTAAINQMLeklegpgafdikhgsilgdtllyseikKSSSLKQNITIlipethktatgssd 2336
Cdd:COG5245   1489 EALNTLRS-YIYCGPPGSGKEMLMCPSL---------------------------RSELITEVKYF-------------- 1526
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2337 nptkkpevrtNKKLLKNNDHKgvvVSTINFSTNvtaaktkemilkkLIRRTKDTLGAPKNN--RILIFIDDMNMPVSDMY 2414
Cdd:COG5245   1527 ----------NFSTCTMTPSK---LSVLERETE-------------YYPNTGVVRLYPKPVvkDLVLFCDEINLPYGFEY 1580
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2415 GAQPPLELIRQLLDLGGVYDTEKNTWKNIQDLSIVAACVPVV----NDISPRLLKHFSMLVLPHPSQDILCTIFQAHLGI 2490
Cdd:COG5245   1581 YPPTVIVFLRPLVERQGFWSSIAVSWVTICGIILYGACNPGTdegrVKYYERFIRKPVFVFCCYPELASLRNIYEAVLMG 1660
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2491 YFSINnftPEVQKSKDQIISCSLAIYHQVRQNMlPTPTKCHYMFNLRDMFKLLLGLLQADRTVVNSKEMAAL-LFVHEAT 2569
Cdd:COG5245   1661 SYLCF---DEFNRLSEETMSASVELYLSSKDKT-KFFLQMNYGYKPRELTRSLRAIFGYAETRIDTPDVSLIiDWYCEAI 1736
                         1370      1380      1390      1400      1410      1420      1430      1440
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2570 RVFHDRLIDFTDKSLFYRLL---------SRELENCFQIQWTQENLMNHSTVFLDFLDinkthrkkiyqntsdynkLASV 2640
Cdd:COG5245   1737 REKIDRLVQQKESSTSRQDLydfglrairEMIAGHIGEAEITFSMILFFGMACLLKKD------------------LAVF 1798
                         1450      1460      1470      1480      1490      1500      1510      1520
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2641 LDEFQMKLGSISLELShsMVFFKEAIEHIIRATRVLRQPGSHMLLIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYI 2720
Cdd:COG5245   1799 VEEVRKIFGSSHLDVE--AVAYKDALLHILRSRRGLLVVGGHGVLKGVLIRGACDAREFVCWLNPRNMREIFGHRDELTG 1876
                         1530      1540      1550      1560      1570      1580      1590      1600
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2721 EFKEVFKKVFIHAGLKGKPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTE-QSGHMDNRQSL 2799
Cdd:COG5245   1877 DFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLEDFNPLLDNNRFLCLFSGNERIRIPENLRFVFEsTSLEKDTEATL 1956
                         1610      1620      1630      1640      1650      1660      1670      1680
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2800 LSFFQKRIYKNLH-IFVIMSPEGPSFRQNCRvYPSMISSCTIDWYERWPEEALLIVANSFLKEKVN----FENRENLK-- 2872
Cdd:COG5245   1957 TRVFLVYMEENLPvVFSACCSQDTSVLAGIR-SPALKNRCFIDFKKLWDTEEMSQYANSVETLSRDggrvFFINGELGvg 2035
                         1690      1700      1710      1720      1730      1740      1750      1760
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2873 ------EKLAPTCVQIHKSmkdlNRKYFEETGRFYYtTPNSYLQFMETFAHILRAREEEMQTKRDRFHMGLSTILEATTL 2946
Cdd:COG5245   2036 kgalisEVFGDDAVVIEGR----GFEISMIEGSLGE-SKIKFIGGLKVYDARCVIYIEELDCTNVNLVEGVRKYNEYGRG 2110
                         1770      1780      1790      1800      1810      1820      1830      1840
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2947 VTEMQEELLILGPQVEQKTKETETLMEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKTANELKSVLPAFDKAIV 3026
Cdd:COG5245   2111 MGELKEQLSNTVVILGVKEKNADDALSGTPGERLEREVKSVFVEAPRDMLFLLEEEVRKRKGSVMKFKSSKKPAVLEAVL 2190
                         1850      1860      1870      1880      1890      1900      1910      1920
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3027 ALNALDKADVAELRVYTRPPFLVLTVMNAVCILLQ-KKPNWATAKLLLSETGFLKKLINLDKD---SIPDKVFVKlKKIV 3102
Cdd:COG5245   2191 FVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLLGfEAKIWFGEQQSLRRDDFIRIIGKYPDEiefDLEARRFRE-AREC 2269
                         1930      1940      1950      1960      1970      1980      1990      2000
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3103 TLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKVVGPKQIQVAEAQNVLKIARQRLAEKQRGLQLVEEHLLFLQAAYK 3182
Cdd:COG5245   2270 SDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPLREEEKRIDGEAFLVEDRLTLGKGLSSDLMTFKLRRRSYYS 2349
                         2010      2020      2030      2040      2050      2060      2070      2080
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3183 DTVAEKQLLANRKTMASRRFQCASVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAACIVYSGILTPEFRQLIVNKW 3262
Cdd:COG5245   2350 LDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSEWGGVFSEVPKLMVELDGDGHPSSCLHPYIGTLGFLCRAIEFGMS 2429
                         2090      2100      2110      2120      2130      2140      2150      2160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3263 ET-FCIENGISLSSKFSLIKVMAQKYEISRWHNQglpHGQYSVENAILIKNGQQ-WPLLIDPHRQAHKWIRQMEGSRLQK 3340
Cdd:COG5245   2430 FIrISKEFRDKEIRRRQFITEGVQKIEDFKEEAC---STDYGLENSRIRKDLQDlTAVLNDPSSKIVTSQRQMYDEKKAI 2506
                         2170      2180      2190      2200      2210      2220      2230      2240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3341 L-SIEDSNYTKKIENAMKTGGSVLLQNlLETLAPGLKAILKKDIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIENPHFL 3419
Cdd:COG5245   2507 LgSFREMEFAFGLSQARREGSDKIIGD-AEALDEEIGRLIKEEFKSNLSEVKVMINPPEIVRSTVEAVFWLSEGRSGDMG 2585
                         2250      2260      2270      2280      2290      2300      2310      2320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3420 PSVYNFVTMINFTVTFQGLQDQLLSTVVTHEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDEIVDT 3499
Cdd:COG5245   2586 SIEWKQLIQVMFVSKVLGCETEIPDALEKLVSGPLFVHEKALNALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVL 2665
                         2330      2340      2350      2360      2370      2380      2390      2400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3500 LRKSKMTSNEISKRIEATKKAESEIQAIRKNYLPIATRGALLYFLVADLTQINYMYQFSLDWFHQvfvssvvskskereh 3579
Cdd:COG5245   2666 LHNLKKSRKEIEEEESESMEIEDRIDALKSEYNASVKRLESIRVEIAMFDEKALMYNKSICELSS--------------- 2730
                         2410      2420      2430      2440      2450      2460      2470      2480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3580 sfkrekvspkEVHEFisiskepnleneKNLLDKHIKSAIDMLTKSIFkvvssALFNEDKLCFSFRLctaimqnnangnli 3659
Cdd:COG5245   2731 ----------EFEKW------------RRMKSKYLCAIRYMLMSSEW-----ILDHEDRSGFIHRL-------------- 2769
                         2490      2500      2510      2520      2530      2540      2550      2560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3660 qdDIGFLPEEEwnIFLYSGILINIKS-ALSQSKLTSTFEIGESqhlqwlSDSRWRQCQYVSTHLEPFSLLCKSLLSNvSQ 3738
Cdd:COG5245   2770 --DVSFLLRTK--RFVSTLLEDKNYRqVLSSCSLYGNDVISHS------CDRFDRDVYRALKHQMDNRTHSTILTSN-SK 2838
                         2570      2580      2590      2600      2610      2620      2630      2640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3739 WDTFKNskavyslistpfssenasleentkppeetELLNENketcnpinfpWEKltsfqrlilvkvlrpeslnnsvrKFI 3818
Cdd:COG5245   2839 TNPYKE-----------------------------YTYNDS----------WAE-----------------------AFE 2856
                         2650      2660      2670      2680      2690      2700      2710      2720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3819 TEKMGNKYLQRTGVNlkdayKGSNARTPLILIQTHGIDLTNILLRfaqelkgtthhvtiisLGRDQAAKAEDLILKALTK 3898
Cdd:COG5245   2857 VEDSGDLYKFEEGLL-----ELIVGHAPLIYAHKKSLENERNVDR----------------LGSKENEVYAVLNSLFSRK 2915
                         2730      2740      2750      2760      2770      2780      2790      2800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3899 TQQWVFLQNCHLATSFMPRLC-TIVESFNSPNVTIDPEfRLWLSSKSYSSFPIPVLkkglkIAVESpqgLKSNLLQTFGC 3977
Cdd:COG5245   2916 EKSWFEVYNISLSFGWFKRYVeDVVYPIKASRVCGKVK-NMWTSMVDADMLPIQLL-----IAIDS---FVSSTYPETGC 2986
                         2810      2820      2830      2840      2850      2860      2870      2880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3978 TGSGEVTEEIFENPDCGQWWKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSDLGVAIKVLENSL-RGQP-SISWQAL 4055
Cdd:COG5245   2987 GYADLVEIDRYPFDYTLVIACDDAFYLSWEHAAVASVISAGPKENNEEIYFGDKDFEFKTHLLKNILfLNHLnARKWGNN 3066
                         2890      2900      2910      2920      2930      2940      2950      2960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 4056 RYLIGEVIYGGRVIDNWDKRclktLLYKFCNPEVLKDDFSFSSDGICLPVPGSASIKDY-------IHIIQSLPDDDLPE 4128
Cdd:COG5245   3067 RDLIFTIVYGKKHSLMEDSK----VVDKYCRGYGAHETSSQILASVPGGDPELVKFHMEemcrssaFGVIGQLPDLALCA 3142
                         2970
                   ....*....|
gi 2462503555 4129 VLGIHPEAIR 4138
Cdd:COG5245   3143 WLMGPCDSEY 3152
Dynein_C pfam18199
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ...
4143-4540 5.42e-97

Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.


Pssm-ID: 465677  Cd Length: 301  Bit Score: 316.48  E-value: 5.42e-97
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 4143 TQGEKFIENLIAMQPKTTTANlmIRPEQSKDELVMEILSDLLKRLPLTVEKEEIAVGTPstlksmmsssiweslsknLKD 4222
Cdd:pfam18199    2 NETNELLSTLLSLQPRSDSGG--GGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKYP------------------VGY 61
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 4223 HDPLIhcvllTFLKQEIKRFDKLLFVIHKSLKDLQLAIKGEIILTQELEEIFNSFLNMRVPTLWQKHAYRSCKPLSSWID 4302
Cdd:pfam18199   62 EDPLN-----TVLLQEIERFNKLLKVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIR 136
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 4303 DLIQRLNFFNTWAKvaytaiqrrymrfvtvwkqsipstsqkckhpedsennfFEGFPSRYWLPAFFFPQAFLAAVLQDYG 4382
Cdd:pfam18199  137 DLLERLKQLQDWLD--------------------------------------DEGPPKVFWLSGFFFPQAFLTAVLQNYA 178
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 4383 RSRGIAVDALTFTHHVISNTTDKDEKfsvfmpkklnivrrafkgsASSHTGVYIFGLFIEGARWNREQKILEDSLPLEMC 4462
Cdd:pfam18199  179 RKNGWPIDKLSFDFEVTKKVSPEEVT-------------------EPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELF 239
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462503555 4463 CDFPDIYFLPTKISTKtpnasnQTDSELYafECPVYQTPERSRilattglpTNFLTSVYLSTKKPPSHWITMRVALLC 4540
Cdd:pfam18199  240 SPLPVIHLKPVESDKK------KLDENTY--ECPVYKTSERHS--------TNFVFSVDLPTDKPPDHWILRGVALLL 301
AAA_9 pfam12781
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ...
3290-3510 2.20e-91

ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.


Pssm-ID: 463702 [Multi-domain]  Cd Length: 222  Bit Score: 297.05  E-value: 2.20e-91
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3290 SRWHNQGLPHGQYSVENAILIKNGQQWPLLIDPHRQAHKWIRQMEGSR-LQKLSIEDSNYTKKIENAMKTGGSVLLQNLL 3368
Cdd:pfam12781    1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDNgLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3369 ETLAPGLKAILKKDIYQKKGHYFIRVGDAEFEYNSNFRLYLSTEIENPHFLPSVYNFVTMINFTVTFQGLQDQLLSTVVT 3448
Cdd:pfam12781   81 EELDPILDPVLLKEIFKGGGRKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462503555 3449 HEVPHLEDQRSKLLESISLDAITLEELEEKTLNLLQKALGSILDDDEIVDTLRKSKMTSNEI 3510
Cdd:pfam12781  161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
AAA_8 pfam12780
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ...
2658-2915 8.53e-83

P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.


Pssm-ID: 463701 [Multi-domain]  Cd Length: 259  Bit Score: 273.71  E-value: 8.53e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2658 SMVFFKEAIEHIIRATRVLRQPGSHMLLIGIDGCGKKTCATLACYLTDNKLYRVPISHKCAYIEFKEVFKKVFIHAGLKG 2737
Cdd:pfam12780    2 DLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIKG 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2738 KPTVLMVPNLNIEQDSFLEDLNYIISSGRIPDLFENVELDSIAMKIRYLTEQSGHMDNRQSLLSFFQKRIYKNLHIFVIM 2817
Cdd:pfam12780   82 KPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLCM 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2818 SPEGPSFRQNCRVYPSMISSCTIDWYERWPEEALLIVANSFLKEKvnfENRENLKEKLAPTCVQIHKSMKDLNRKYFEET 2897
Cdd:pfam12780  162 SPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDI---EIPEELKSNVVKVFVYVHSSVEDMSKKFYEEL 238
                          250
                   ....*....|....*...
gi 2462503555 2898 GRFYYTTPNSYLQFMETF 2915
Cdd:pfam12780  239 KRKNYVTPKSYLELLRLY 256
AAA_lid_11 pfam18198
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the ...
3997-4136 3.98e-63

Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the C-terminal region of dynein heavy chain.


Pssm-ID: 465676  Cd Length: 139  Bit Score: 212.31  E-value: 3.98e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3997 WKKLLFSLCFFNAVINERKNYGILGWNIAYKFNSSDLGVAIKVLENSLRGQPS-ISWQALRYLIGEVIYGGRVIDNWDKR 4075
Cdd:pfam18198    1 WKKLLFGLCFFHAVVQERRKFGPLGWNIPYEFNESDLRISVQQLQMYLDEYDEkIPWDALRYLIGEINYGGRVTDDWDRR 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462503555 4076 CLKTLLYKFCNPEVLKDDFSFSSDGIclPVPGSASIKDYIHIIQSLPDDDLPEVLGIHPEA 4136
Cdd:pfam18198   81 LLNTYLEEFFNPEVLEEDFKFSPSLY--YIPPDGDLEDYLEYIESLPLVDSPEVFGLHPNA 139
AAA_7 pfam12775
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ...
2246-2475 1.97e-55

P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).


Pssm-ID: 463698 [Multi-domain]  Cd Length: 179  Bit Score: 192.22  E-value: 1.97e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2246 TRDTTCLSFLMSLLLKNSCPVLLTGESGVGKTAAINQMLEKLegpgafdikhgsilgdtllyseikkssslkqnitilip 2325
Cdd:pfam12775   14 TVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKL-------------------------------------- 55
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2326 ethktatgssdnptkkpevrtnkkllknnDHKGVVVSTINFSTNVTAAKTKEMILKKLIRRTKDTLGAPKNNRILIFIDD 2405
Cdd:pfam12775   56 -----------------------------DKEKYLPLFINFSAQTTSNQTQDIIESKLEKRRKGVYGPPGGKKLVVFIDD 106
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462503555 2406 MNMPVSDMYGAQPPLELIRQLLDLGGVYDTEKNTWKNIQDLSIVAACVPVV---NDISPRLLKHFSMLVLPHP 2475
Cdd:pfam12775  107 LNMPAVDTYGAQPPIELLRQWLDYGGWYDRKKLTFKEIVDVQFVAAMGPPGggrNDITPRLLRHFNVFNITFP 179
MT pfam12777
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
2931-3265 2.87e-39

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 151.76  E-value: 2.87e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2931 DRFHMGLSTILEATTLVTEMQEELLILGPQVEQKTKETETLMEKLRKDSQVVEKVQMLVKQDEEIVAEEVRIVEDYAQKT 3010
Cdd:pfam12777    1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3011 ANELKSVLPAFDKAIVALNALDKADVAELRVYTRPPFLVLTVMNAVCILLQ------KKPNWATAKLLLSET-GFLKKLI 3083
Cdd:pfam12777   81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMApggkipKDKSWKAAKIMMAKVdGFLDSLI 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3084 NLDKDSIPDKVFVKLKKIVTLPDFNPHKISLVSVACCSLCQWVIALNNYHEVQKVVGPKQIQVAEAQNVLKIARQRLAEK 3163
Cdd:pfam12777  161 KFDKEHIHEACLKAFKPYLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAAI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3164 QRGLQLVEEHLLFLQAAYKDTVAEKQLLANRKTMASRRFQCASVLLTVLEDEKTRWQETINQIDNKLEGILGDILLSAAC 3243
Cdd:pfam12777  241 KAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISAF 320
                          330       340
                   ....*....|....*....|...
gi 2462503555 3244 IVYSGILTPEFRQLIVNK-WETF 3265
Cdd:pfam12777  321 ISYLGFFTKKYRNELLDKfWIPY 343
Dynein_heavy pfam03028
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of ...
3842-3959 6.38e-37

Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.


Pssm-ID: 460782  Cd Length: 115  Bit Score: 136.42  E-value: 6.38e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 3842 NARTPLILIQTHGIDLTNILLRFAQELKGTTHhVTIISLGRDQAAKAEDLILKAlTKTQQWVFLQNCHLATSFMPRLCTI 3921
Cdd:pfam03028    1 SPTTPLIFILSPGSDPTADLEKLAKKLGFGGK-LHSISLGQGQGPIAEKLIEEA-AKEGGWVLLQNCHLALSWMPELEKI 78
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 2462503555 3922 VESFnsPNVTIDPEFRLWLSSKSYSSFPIPVLKKGLKI 3959
Cdd:pfam03028   79 LEEL--PEETLHPDFRLWLTSEPSPKFPISILQNSIKI 114
Dynein_AAA_lid pfam17852
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA ...
2020-2205 5.96e-18

Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA domain 5 in the dynein heavy chain. This domain is composed of 8 alpha helices.


Pssm-ID: 465532 [Multi-domain]  Cd Length: 126  Bit Score: 82.72  E-value: 5.96e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2020 LEFMIKNSVTDGLQFIRNRQKfQPYPMEDITVVITLCRILDAFFDfmgknggfeqsddlndtsskeansqresvtfkdiE 2099
Cdd:pfam17852    1 LEPLFEWLVPPALEFVRKNCK-EIVPTSDLNLVQSLCRLLESLLD----------------------------------E 45
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2100 KRDENTWYPEkNPDKLTKIIQKLFVFAFTWAFGGALNreDEHREnipfcpslepdslakvtyDFDKLVHELFGnssqvGI 2179
Cdd:pfam17852   46 VLEYNGVHPL-SPDKLKEYLEKLFLFALVWSIGGTLD--EDSRK------------------KFDEFLRELFS-----GL 99
                          170       180
                   ....*....|....*....|....*..
gi 2462503555 2180 NLPTGEC-SIFGYFVDIEQCEFIPWSD 2205
Cdd:pfam17852  100 DLPPPEKgTVYDYFVDLEKGEWVPWSD 126
AAA_lid_1 pfam17857
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.
2508-2597 5.07e-11

AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.


Pssm-ID: 465535 [Multi-domain]  Cd Length: 100  Bit Score: 62.26  E-value: 5.07e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 2508 IISCSLAIYHQVRQNMLPTPTKCHYMFNLRDMFKLLLGLLQADRTVVNSKEMAALLFVHEATRVFHDRLIDFTDKSLFYR 2587
Cdd:pfam17857    1 LIAAALAFHQKIAATFLPTAIKFHYIFNLRDFANIFQGILFSSAECLKSPLDLIRLWLHESERVYGDKMVDEKDFDLFDK 80
                           90
                   ....*....|
gi 2462503555 2588 LLSRELENCF 2597
Cdd:pfam17857   81 IQMASLKKFF 90
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
1849-1985 6.93e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 45.75  E-value: 6.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462503555 1849 GVMLVGPTGGGKTTVRRILEKALTllpiadflsvaerkSASKVFKLDSSDTTETDdnIFEEIEkvvkiPENHNFDWQ--- 1925
Cdd:pfam07728    1 GVLLVGPPGTGKTELAERLAAALS--------------NRPVFYVQLTRDTTEED--LFGRRN-----IDPGGASWVdgp 59
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462503555 1926 --------WIILDGPVDTF---WVENLNSVLDDTRTLCLANSERI-ALTNKIRVIFEVDNLSQ----ASPATVSRC 1985
Cdd:pfam07728   60 lvraaregEIAVLDEINRAnpdVLNSLLSLLDERRLLLPDGGELVkAAPDGFRLIATMNPLDRglneLSPALRSRF 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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