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Conserved domains on  [gi|2462511035|ref|XP_054193470|]
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mucolipin-3 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ELD_TRPML3 cd21072
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 3 ...
 133-301 8.54e-120

extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 3 (TRPML3); TRPML3, also called mucolipin-3 (ML3), acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. It mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. The model corresponds to extracytosolic/lumenal domain (ELD), a linker located between the first two transmembrane segments (S1 and S2) of TRPML3. It forms a tight tetramer that is crucial for full-length TRPML3 assembly and localization.


:

Pssm-ID: 410968  Cd Length: 169  Bit Score: 350.93  E-value: 8.54e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035 133 RMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFV 212
Cdd:cd21072     1 RMDDTYAVYTQSDVYDHIDFIINQYLQLQNISVGNHAYERKGTKQTPLSICQDFYKRGSIFPGNETFDIDPEIETECFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035 213 EPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRE 292
Cdd:cd21072    81 YPLQPFHNGTAAENKLNFTLDFHRLLSVEVHFKLKAINLQTVRHHELPDCYDFTVTITFDNKAHSGRIKISLDNDVDIRE 160


                  ....*....
gi 2462511035 293 CKDWHVSGS 301
Cdd:cd21072   161 CKDWHVSGS 169
PKD_channel super family cl37568
Polycystin cation channel; This family contains the cation channel region from group II of ...
 399-532 1.29e-08

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


The actual alignment was detected with superfamily member pfam08016:

Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 55.75  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035 399 ILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSL 478
Cdd:pfam08016  98 IILAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQAPNFSNFVKSILTLFRT 177

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462511035 479 INGDDMFATFAKMQQksylvwLFSRIYLYSFISLFIYMILSLFIALITDTYETI 532
Cdd:pfam08016 178 ILGDFGYNEIFSGNR------VLGPLLFLTFVFLVIFILLNLFLAIINDSYVEV 225
 
Name Accession Description Interval E-value
ELD_TRPML3 cd21072
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 3 ...
 133-301 8.54e-120

extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 3 (TRPML3); TRPML3, also called mucolipin-3 (ML3), acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. It mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. The model corresponds to extracytosolic/lumenal domain (ELD), a linker located between the first two transmembrane segments (S1 and S2) of TRPML3. It forms a tight tetramer that is crucial for full-length TRPML3 assembly and localization.


Pssm-ID: 410968  Cd Length: 169  Bit Score: 350.93  E-value: 8.54e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035 133 RMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFV 212
Cdd:cd21072     1 RMDDTYAVYTQSDVYDHIDFIINQYLQLQNISVGNHAYERKGTKQTPLSICQDFYKRGSIFPGNETFDIDPEIETECFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035 213 EPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRE 292
Cdd:cd21072    81 YPLQPFHNGTAAENKLNFTLDFHRLLSVEVHFKLKAINLQTVRHHELPDCYDFTVTITFDNKAHSGRIKISLDNDVDIRE 160


                  ....*....
gi 2462511035 293 CKDWHVSGS 301
Cdd:cd21072   161 CKDWHVSGS 169
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 399-532 1.29e-08

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 55.75  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035 399 ILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSL 478
Cdd:pfam08016  98 IILAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQAPNFSNFVKSILTLFRT 177

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462511035 479 INGDDMFATFAKMQQksylvwLFSRIYLYSFISLFIYMILSLFIALITDTYETI 532
Cdd:pfam08016 178 ILGDFGYNEIFSGNR------VLGPLLFLTFVFLVIFILLNLFLAIINDSYVEV 225
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
 400-538 2.44e-05

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 47.63  E-value: 2.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035  400 LLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLI 479
Cdd:PLN03223  1294 LSGINIILLLGRILKLMDFQPRLGVITRTLWLAGADLMHFFVIFGMVFVGYAFIGHVIFGNASVHFSDMTDSINSLFENL 1373

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462511035  480 NGD-DMFatFAKMQQKSYLVWLFSRIYLYSFiSLFIYMILSLF-IALITDTYETIKQYQQD 538
Cdd:PLN03223  1374 LGDiTYF--NEDLKNLTGLQFVVGMIYFYSY-NIFVFMILFNFlLAIICDAFGEVKANAAE 1431
 
Name Accession Description Interval E-value
ELD_TRPML3 cd21072
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 3 ...
 133-301 8.54e-120

extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 3 (TRPML3); TRPML3, also called mucolipin-3 (ML3), acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. It mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. The model corresponds to extracytosolic/lumenal domain (ELD), a linker located between the first two transmembrane segments (S1 and S2) of TRPML3. It forms a tight tetramer that is crucial for full-length TRPML3 assembly and localization.


Pssm-ID: 410968  Cd Length: 169  Bit Score: 350.93  E-value: 8.54e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035 133 RMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFV 212
Cdd:cd21072     1 RMDDTYAVYTQSDVYDHIDFIINQYLQLQNISVGNHAYERKGTKQTPLSICQDFYKRGSIFPGNETFDIDPEIETECFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035 213 EPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRE 292
Cdd:cd21072    81 YPLQPFHNGTAAENKLNFTLDFHRLLSVEVHFKLKAINLQTVRHHELPDCYDFTVTITFDNKAHSGRIKISLDNDVDIRE 160


                  ....*....
gi 2462511035 293 CKDWHVSGS 301
Cdd:cd21072   161 CKDWHVSGS 169
ELD_TRPML1 cd21070
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 1 ...
 135-300 7.23e-74

extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 1 (TRPML1); TRPML1, also called mucolipin-1 (ML1), or MG-2, or Mucolipidin, may play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. The model corresponds to extracytosolic/lumenal domain (ELD), a linker located between the first two transmembrane segments (S1 and S2) of TRPML1. It forms a tight tetramer that is crucial for full-length TRPML1 assembly and localization.


Pssm-ID: 410966  Cd Length: 171  Bit Score: 233.15  E-value: 7.23e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035 135 DDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAY-ENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVE 213
Cdd:cd21070     3 DDTFAVYTQEDLYQAIFYAVDQYLALPNVTLGRYAYvRGGWTNGSALALCQQYYHKGHIDPANDTFNIDPLVVTDCIGVD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035 214 PDEPFH-IGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRE 292
Cdd:cd21070    83 PPERPPpPLESSRSYKNFTLKFHKLINVTIQFQLKAINLQTIINNEIPDCYTFSITITFDNKAHSGRIKISLENQAHIKE 162


                  ....*...
gi 2462511035 293 CKDWHVSG 300
Cdd:cd21070   163 CKDPSVFG 170
ELD_TRPML2 cd21071
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 2 ...
 132-296 7.79e-59

extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipin 2 (TRPML2); TRPML2, also called mucolipin-2 (ML2), acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. It may activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway. The model corresponds to extracytosolic/lumenal domain (ELD), a linker located between the first two transmembrane segments (S1 and S2) of TRPML2. It forms a tight tetramer that is crucial for full-length TRPML2 assembly and localization.


Pssm-ID: 410967  Cd Length: 167  Bit Score: 193.38  E-value: 7.79e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035 132 DRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFF 211
Cdd:cd21071     3 DEDDYSIAVYTQQDVYDSLFYAIDQYAQLKNLSVGPLSYAEDEDELLPLKICKQLYKKGSVKPSEEVYDIDAQLETVCLT 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035 212 VEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIR 291
Cdd:cd21071    83 IDPKTLNDKKWKMSNSSFFELDFYRLVQIEITFRLKGINLQTIRSRELPDCYTFFVTITFDNQCHSGKIKIYFDSDAVSS 162


                  ....*
gi 2462511035 292 ECKDW 296
Cdd:cd21071   163 ACKDW 167
ELD_TRPML cd21050
extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipins ...
 138-294 1.20e-58

extracytosolic/lumenal domain (ELD) found in transient receptor potential channel mucolipins (TRPMLs); TRPML family proteins contain a linker between the first two transmembrane helices (S1 and S2), which is called TRPML I-II linker. It forms a tight tetramer that is crucial for full-length TRPMLs assembly and localization. In lysosomes and endosomes, this linker faces the lumen (it is therefore also referred to as the 'luminal linker'); on the plasma membrane, it faces the extracellular solution. TRPML I-II linker has been named as extracytosolic/lumenal domain (ELD).


Pssm-ID: 410965  Cd Length: 167  Bit Score: 192.85  E-value: 1.20e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035 138 YAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEP 217
Cdd:cd21050     6 YAVYTKDDFYEHLDFAVNQYYNLENIAIGSYGYDSNNGTPPPITLCVTQYKNGEVDPFNNTYVFDPTVITDCLSIPPTYP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035 218 FHIGTPAENK-----LNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRE 292
Cdd:cd21050    86 ENDNLWDSIKdflksKNFTLNFDRLIKIELKFSLKTIHLKSLKPLDSPECYKFNVTILFDNSAHDGQMPVSLDTNISELE 165


                  ..
gi 2462511035 293 CK 294
Cdd:cd21050   166 CN 167
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 399-532 1.29e-08

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 55.75  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035 399 ILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSL 478
Cdd:pfam08016  98 IILAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQAPNFSNFVKSILTLFRT 177

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462511035 479 INGDDMFATFAKMQQksylvwLFSRIYLYSFISLFIYMILSLFIALITDTYETI 532
Cdd:pfam08016 178 ILGDFGYNEIFSGNR------VLGPLLFLTFVFLVIFILLNLFLAIINDSYVEV 225
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 409-537 7.95e-06

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 47.26  E-value: 7.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035 409 WLGVIRYLGFFAKYNLLILTLQAALPNVIRFC----------CCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSL 478
Cdd:pfam00520 102 LLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLlllllflfifAIIGYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQT 181

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462511035 479 INGDDMFATFAKMQQKSYLVWlfSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQ 537
Cdd:pfam00520 182 MTTEGWGDIMYDTIDGKGEFW--AYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
 400-538 2.44e-05

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 47.63  E-value: 2.44e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462511035  400 LLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLI 479
Cdd:PLN03223  1294 LSGINIILLLGRILKLMDFQPRLGVITRTLWLAGADLMHFFVIFGMVFVGYAFIGHVIFGNASVHFSDMTDSINSLFENL 1373

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462511035  480 NGD-DMFatFAKMQQKSYLVWLFSRIYLYSFiSLFIYMILSLF-IALITDTYETIKQYQQD 538
Cdd:PLN03223  1374 LGDiTYF--NEDLKNLTGLQFVVGMIYFYSY-NIFVFMILFNFlLAIICDAFGEVKANAAE 1431
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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