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Conserved domains on  [gi|2462512927|ref|XP_054194383|]
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NAD kinase isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pnk super family cl28462
bifunctional NADP phosphatase/NAD kinase;
96-433 3.66e-93

bifunctional NADP phosphatase/NAD kinase;


The actual alignment was detected with superfamily member PLN02727:

Pssm-ID: 333282 [Multi-domain]  Cd Length: 986  Bit Score: 302.19  E-value: 3.66e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927  96 QRLTWNKSPKSVLVIKKMRDAsLLQPFKELCTHLM-EENMIVYVEKKVLEdpAIASDESFGAVKkkfcTF-REDYDDISN 173
Cdd:PLN02727  670 QMLMWKSTPKTVLLLKKLGQE-LMEEAKEVASFLYhQEKMNVLVEPDVHD--IFARIPGFGFVQ----TFySQDTSDLHE 742

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 174 QIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAA-----VVLRSRLKVRVVKel 248
Cdd:PLN02727  743 RVDFVACLGGDGVILHASNLFRGAVPPVVSFNLGSLGFLTSHYFEDFRQDLRQVIHGNNTldgvyITLRMRLRCEIFR-- 820

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 249 rgkktavhnglgeNGSQAAGLDMDVgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYA 328
Cdd:PLN02727  821 -------------NGKAMPGKVFDV---------LNEVVVDRGSNPYLSKIECYEHDRLITKVQGDGVIVATPTGSTAYS 878

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 329 AAAGASMIHPNVPAIMITPICPHSLSFRPIVVP--AGVELKImlSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLP 406
Cdd:PLN02727  879 TAAGGSMVHPNVPCMLFTPICPHSLSFRPVILPdsARLELKI--PDDARSNAWVSFDGKRRQQLSRGDSVRISMSQHPLP 956

                         330       340
                  ....*....|....*....|....*..
gi 2462512927 407 SICVRDPVSDWFESLAQCLHWNVRKKQ 433
Cdd:PLN02727  957 TVNKSDQTGDWFRSLIRCLNWNERLDQ 983
 
Name Accession Description Interval E-value
PLN02727 PLN02727
NAD kinase
 96-433 3.66e-93

NAD kinase


Pssm-ID: 215386 [Multi-domain]  Cd Length: 986  Bit Score: 302.19  E-value: 3.66e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927  96 QRLTWNKSPKSVLVIKKMRDAsLLQPFKELCTHLM-EENMIVYVEKKVLEdpAIASDESFGAVKkkfcTF-REDYDDISN 173
Cdd:PLN02727  670 QMLMWKSTPKTVLLLKKLGQE-LMEEAKEVASFLYhQEKMNVLVEPDVHD--IFARIPGFGFVQ----TFySQDTSDLHE 742

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 174 QIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAA-----VVLRSRLKVRVVKel 248
Cdd:PLN02727  743 RVDFVACLGGDGVILHASNLFRGAVPPVVSFNLGSLGFLTSHYFEDFRQDLRQVIHGNNTldgvyITLRMRLRCEIFR-- 820

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 249 rgkktavhnglgeNGSQAAGLDMDVgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYA 328
Cdd:PLN02727  821 -------------NGKAMPGKVFDV---------LNEVVVDRGSNPYLSKIECYEHDRLITKVQGDGVIVATPTGSTAYS 878

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 329 AAAGASMIHPNVPAIMITPICPHSLSFRPIVVP--AGVELKImlSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLP 406
Cdd:PLN02727  879 TAAGGSMVHPNVPCMLFTPICPHSLSFRPVILPdsARLELKI--PDDARSNAWVSFDGKRRQQLSRGDSVRISMSQHPLP 956

                         330       340
                  ....*....|....*....|....*..
gi 2462512927 407 SICVRDPVSDWFESLAQCLHWNVRKKQ 433
Cdd:PLN02727  957 TVNKSDQTGDWFRSLIRCLNWNERLDQ 983
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
105-430 6.23e-60

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 196.90  E-value: 6.23e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 105 KSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEDPAiasdesfgavkkkfctfreDYDDISNQIDFIICLGGD 184
Cdd:COG0061     2 KRIAIVAKPGKPEALEAAEELAELLEERGIEVVLDEDTAVPGV-------------------PLEELGEEADLVIVLGGD 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 185 GTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKElrgkktavhnglgengs 264
Cdd:COG0061    63 GTLLRAARLLAPLGIPILGINLGRLGFLTEIEPEELEEALERLLAGEYEVEERLLLEATVDRD----------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 265 qaagldmdvGKQAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTgstayaaaagasMIHPNVPAIM 344
Cdd:COG0061   126 ---------GEVVHEALALNEVVVLRGSIARMIELEVYIDGEFLEEFRGDGLIVSTPTgstaynlsaggpIVHPGLDALV 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 345 ITPICPHSLSFRPIVVPAGVELKIMLSPEARNtAWVSFDGRKRQEIRHGDSISITTSCYPLpSIcVRDPVSDWFESLAQC 424
Cdd:COG0061   197 LTPIAPHTLSSRPLVLPDDSEIEIEVLEDSRP-AVLVADGQEVRDLEPGDRVEIRRSPKPV-RL-LRLKDHSFFERLREK 273


                  ....*.
gi 2462512927 425 LHWNVR 430
Cdd:COG0061   274 LGWGGD 279
NAD_kinase_C pfam20143
ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 283-408 1.65e-31

ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86. This entry represents the C-terminal beta sandwich domain.


Pssm-ID: 437975 [Multi-domain]  Cd Length: 125  Bit Score: 117.02  E-value: 1.65e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 283 LNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPA 362
Cdd:pfam20143   1 LNEVVYVRGPGATMIEFELYVDGELLGVDRADGLIVSTPTGSTAYSLSAGGPIISPRVLAILIVPICPHSLSSRPIVVSS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2462512927 363 GVELKIMlsPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSI 408
Cdd:pfam20143  81 SSKLRIR--VLSRAEALLVDDGDPELDISPGDRVRVRKSYYKAKFI 124
 
Name Accession Description Interval E-value
PLN02727 PLN02727
NAD kinase
 96-433 3.66e-93

NAD kinase


Pssm-ID: 215386 [Multi-domain]  Cd Length: 986  Bit Score: 302.19  E-value: 3.66e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927  96 QRLTWNKSPKSVLVIKKMRDAsLLQPFKELCTHLM-EENMIVYVEKKVLEdpAIASDESFGAVKkkfcTF-REDYDDISN 173
Cdd:PLN02727  670 QMLMWKSTPKTVLLLKKLGQE-LMEEAKEVASFLYhQEKMNVLVEPDVHD--IFARIPGFGFVQ----TFySQDTSDLHE 742

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 174 QIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAA-----VVLRSRLKVRVVKel 248
Cdd:PLN02727  743 RVDFVACLGGDGVILHASNLFRGAVPPVVSFNLGSLGFLTSHYFEDFRQDLRQVIHGNNTldgvyITLRMRLRCEIFR-- 820

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 249 rgkktavhnglgeNGSQAAGLDMDVgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYA 328
Cdd:PLN02727  821 -------------NGKAMPGKVFDV---------LNEVVVDRGSNPYLSKIECYEHDRLITKVQGDGVIVATPTGSTAYS 878

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 329 AAAGASMIHPNVPAIMITPICPHSLSFRPIVVP--AGVELKImlSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLP 406
Cdd:PLN02727  879 TAAGGSMVHPNVPCMLFTPICPHSLSFRPVILPdsARLELKI--PDDARSNAWVSFDGKRRQQLSRGDSVRISMSQHPLP 956

                         330       340
                  ....*....|....*....|....*..
gi 2462512927 407 SICVRDPVSDWFESLAQCLHWNVRKKQ 433
Cdd:PLN02727  957 TVNKSDQTGDWFRSLIRCLNWNERLDQ 983
PLN02935 PLN02935
Bifunctional NADH kinase/NAD(+) kinase
 98-433 1.93e-88

Bifunctional NADH kinase/NAD(+) kinase


Pssm-ID: 215505 [Multi-domain]  Cd Length: 508  Bit Score: 278.25  E-value: 1.93e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927  98 LTWNKSPKSVLVIKKMRDASLLQPFKELCTHLMEENMI-VYVEKKVLEDpAIASDESFGAVKKkfCTFREDYDDISNQID 176
Cdd:PLN02935  188 LKWESDPQTVLIITKPNSTSVRVLCAEMVRWLREQKGLnIYVEPRVKKE-LLSESSYFNFVQT--WEDEKEILLLHTKVD 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 177 FIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKElrgkktAVH 256
Cdd:PLN02935  265 LVITLGGDGTVLWAASMFKGPVPPVVPFSMGSLGFMTPFHSEQYRDCLDAILKGPISITLRHRLQCHIIRD------AAK 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 257 NGLGENGSqaagldmdvgkqamqYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMI 336
Cdd:PLN02935  339 NEYETEEP---------------ILVLNEVTIDRGISSFLTNLECYCDNSFVTCVQGDGLILSTTSGSTAYSLAAGGSMV 403

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 337 HPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDPVSD 416
Cdd:PLN02935  404 HPQVPGILFTPICPHSLSFRPLILPEYVTIRVQVPFNSRGQAWASFDGKDRKQLSAGDALVCSMAPWPVPTACQVESTND 483

                         330
                  ....*....|....*..
gi 2462512927 417 WFESLAQCLHWNVRKKQ 433
Cdd:PLN02935  484 FLRSIHDGLHWNLRKTQ 500
NadK COG0061
NAD kinase [Coenzyme transport and metabolism];
105-430 6.23e-60

NAD kinase [Coenzyme transport and metabolism];


Pssm-ID: 439831 [Multi-domain]  Cd Length: 279  Bit Score: 196.90  E-value: 6.23e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 105 KSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEDPAiasdesfgavkkkfctfreDYDDISNQIDFIICLGGD 184
Cdd:COG0061     2 KRIAIVAKPGKPEALEAAEELAELLEERGIEVVLDEDTAVPGV-------------------PLEELGEEADLVIVLGGD 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 185 GTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKElrgkktavhnglgengs 264
Cdd:COG0061    63 GTLLRAARLLAPLGIPILGINLGRLGFLTEIEPEELEEALERLLAGEYEVEERLLLEATVDRD----------------- 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 265 qaagldmdvGKQAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTgstayaaaagasMIHPNVPAIM 344
Cdd:COG0061   126 ---------GEVVHEALALNEVVVLRGSIARMIELEVYIDGEFLEEFRGDGLIVSTPTgstaynlsaggpIVHPGLDALV 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 345 ITPICPHSLSFRPIVVPAGVELKIMLSPEARNtAWVSFDGRKRQEIRHGDSISITTSCYPLpSIcVRDPVSDWFESLAQC 424
Cdd:COG0061   197 LTPIAPHTLSSRPLVLPDDSEIEIEVLEDSRP-AVLVADGQEVRDLEPGDRVEIRRSPKPV-RL-LRLKDHSFFERLREK 273


                  ....*.
gi 2462512927 425 LHWNVR 430
Cdd:COG0061   274 LGWGGD 279
ppnK PRK01231
NAD(+) kinase;
101-430 5.54e-38

NAD(+) kinase;


Pssm-ID: 179257 [Multi-domain]  Cd Length: 295  Bit Score: 139.71  E-value: 5.54e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 101 NKSPKSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLE-----DPAIASDESFGAVkkkfCtfredyddisnqi 175
Cdd:PRK01231    1 MPSFRNIGLIGRLGSSSVVETLRRLKDFLLDRGLEVILDEETAEvlpghGLQTVSRKLLGEV----C------------- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 176 DFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVrvvkELRGKKTAV 255
Cdd:PRK01231   64 DLVIVVGGDGSLLGAARALARHNVPVLGINRGRLGFLTDIRPDELEFKLAEVLDGHYQEEERFLLEA----EVRRGGEVI 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 256 HNGLGengsqaagldmdvgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASM 335
Cdd:PRK01231  140 GQGDA----------------------LNDVVLHPGKSTRMIEFELYIDGQFVCSQRSDGLIVSTPTGSTAYALSGGGPI 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 336 IHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDpvS 415
Cdd:PRK01231  198 MHPKLDAIVLVPMFPHTLSSRPIVVDGNSEIKIVISKDNRTYPRVSCDGQNSVTLAPGDTVTIRKKPQKLRLIHPLD--Y 275

                         330
                  ....*....|....*
gi 2462512927 416 DWFESLAQCLHWNVR 430
Cdd:PRK01231  276 NYYETCRTKLGWGSR 290
pnk PRK14076
bifunctional NADP phosphatase/NAD kinase;
100-401 3.25e-37

bifunctional NADP phosphatase/NAD kinase;


Pssm-ID: 237601 [Multi-domain]  Cd Length: 569  Bit Score: 142.94  E-value: 3.25e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 100 WNKSPKSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEdpaiasdesfgAVKKKFCTFREDYDDISNqIDFII 179
Cdd:PRK14076  286 WRIKPTKFGIVSRIDNEEAINLALKIIKYLDSKGIPYELESFLYN-----------KLKNRLNEECNLIDDIEE-ISHII 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 180 CLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKelrgkktavhngl 259
Cdd:PRK14076  354 SIGGDGTVLRASKLVNGEEIPIICINMGTVGFLTEFSKEEIFKAIDSIISGEYEIEKRTKLSGFILK------------- 420

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 260 gengsqaagldmdVGKQAMQYQVLNEVVI-DRGPSSYLsNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHP 338
Cdd:PRK14076  421 -------------DGHQNILPSALNEVVItTKNPAKML-HFEVYVNGELVEEVRADGIIISTPTGSTAYSLSAGGPIVEP 486

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462512927 339 NVPAIMITPICPHSLSFRPIVVPAGVELKIMLSpeaRNTAWVSFDGRKRQEIRHGDSISITTS 401
Cdd:PRK14076  487 TVDGFIIVPICPFKLSSRPLVVSANSEIKIKLL---KKSALVVIDGSIEFEAKKGDEIIFRKS 546
ppnK PRK02155
NAD kinase;
167-428 2.29e-32

NAD kinase;


Pssm-ID: 179379 [Multi-domain]  Cd Length: 291  Bit Score: 124.28  E-value: 2.29e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 167 DYDDISNQIDFIICLGGDGTLL-YASSLFQGSVPPVMAFHlGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVV 245
Cdd:PRK02155   56 TPEEIGARADLAVVLGGDGTMLgIGRQLAPYGVPLIGINH-GRLGFITDIPLDDMQETLPPMLAGNYEEEERMLLEARVV 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 246 kelRGKKTaVHNGLgengsqaagldmdvgkqAMqyqvlNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGST 325
Cdd:PRK02155  135 ---RDGEP-IFHAL-----------------AF-----NDVVVNRSGFSGMVELRVSVDGRFMYNQRSDGLIVATPTGST 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 326 AYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSpEARNTAwVSFDGRKRQEIRHGDSISITTSCYpl 405
Cdd:PRK02155  189 AYALSAGGPILHPQLPGWVLVPIAPHTLSNRPIVLPDDSEVAIQIV-GGRDVS-VNFDMQSLTSLELGDRIEVRRSPH-- 264

                         250       260
                  ....*....|....*....|....
gi 2462512927 406 pSICVRDPVS-DWFESLAQCLHWN 428
Cdd:PRK02155  265 -TVRFLHPVGySYYATLRKKLHWN 287
NAD_kinase_C pfam20143
ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 283-408 1.65e-31

ATP-NAD kinase C-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86. This entry represents the C-terminal beta sandwich domain.


Pssm-ID: 437975 [Multi-domain]  Cd Length: 125  Bit Score: 117.02  E-value: 1.65e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 283 LNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPA 362
Cdd:pfam20143   1 LNEVVYVRGPGATMIEFELYVDGELLGVDRADGLIVSTPTGSTAYSLSAGGPIISPRVLAILIVPICPHSLSSRPIVVSS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 2462512927 363 GVELKIMlsPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSI 408
Cdd:pfam20143  81 SSKLRIR--VLSRAEALLVDDGDPELDISPGDRVRVRKSYYKAKFI 124
ppnK PRK04539
inorganic polyphosphate/ATP-NAD kinase; Provisional
 125-430 6.88e-31

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 179862 [Multi-domain]  Cd Length: 296  Bit Score: 120.35  E-value: 6.88e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 125 LCTHLMEENMIVYVEKKVLEDPAIASDESFGavkkkfCTFReDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAF 204
Cdd:PRK04539   26 LITFLKQHGFTVYLDEVGIKEGCIYTQDTVG------CHIV-NKTELGQYCDLVAVLGGDGTFLSVAREIAPRAVPIIGI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 205 HLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKElrgkktavhnglgengsqaagldmdvGKQAMQYQVLN 284
Cdd:PRK04539   99 NQGHLGFLTQIPREYMTDKLLPVLEGKYLAEERILIEAALIRE--------------------------GKTAERALALN 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 285 EVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGV 364
Cdd:PRK04539  153 DAVLSRGGAGQMIEFEVFVNREFVYTQRSDGLIVSTPTGSTAYSLAAGGPIMQAGLHAFTLVPICPQSMTNRPIAIPDTS 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462512927 365 ELKIMLSP--EARntawVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDpvSDWFESLAQCLHWNVR 430
Cdd:PRK04539  233 EIEILVTQggDAR----VHFDGQTHIDVQNLDRITIRRYRNPLRILHPTD--YQYFKTLRQKLHWGEQ 294
ppnK PRK01911
inorganic polyphosphate/ATP-NAD kinase; Provisional
 123-385 5.41e-29

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 179352 [Multi-domain]  Cd Length: 292  Bit Score: 115.02  E-value: 5.41e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 123 KELCTHLMEENMIVYVEKKVLEdpAIASDESFgavKKKFCTFrEDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVM 202
Cdd:PRK01911   19 QELFDELEERGAEVLIEEKFLD--FLKQDLKF---HPSYDTF-SDNEELDGSADMVISIGGDGTFLRTATYVGNSNIPIL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 203 AFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKELRGkktavhnglgenGSQAAgldmdvgkqamqyqv 282
Cdd:PRK01911   93 GINTGRLGFLATVSKEEIEETIDELLNGDYTIEERSLLQLESNPKLFG------------ELNFA--------------- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 283 LNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPA 362
Cdd:PRK01911  146 LNEIAILKRDTSSMITVHTYLNGEYLNSYWADGLIVATPTGSTGYSLSCGGPIIVPDAKSFVITPIAPHNLNVRPLVIPD 225

                         250       260
                  ....*....|....*....|....
gi 2462512927 363 GVElkIMLSPEARNTAW-VSFDGR 385
Cdd:PRK01911  226 DTE--ITLEVESRSDNFlVSLDSR 247
ppnK PRK01185
NAD(+) kinase;
176-401 5.28e-28

NAD(+) kinase;


Pssm-ID: 179241 [Multi-domain]  Cd Length: 271  Bit Score: 111.83  E-value: 5.28e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 176 DFIICLGGDGTLLYASSLFQGsvpPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVvkelrgkktav 255
Cdd:PRK01185   54 DVIITIGGDGTILRTLQRAKG---PILGINMGGLGFLTEIEIDEVGSAIKKLIRGEYFIDERMKLKVYI----------- 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 256 hnglgeNGSQAagldmdvgkqamqYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASM 335
Cdd:PRK01185  120 ------NGERL-------------EDCTNEAVIHTDRIAKIRQFKIYYDGHFLDTFKADGVIVATPTGSTSYSSSAGGPI 180

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462512927 336 IHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNTawVSFDGRKRQEIRHGDSISITTS 401
Cdd:PRK01185  181 LLPNLEGMVISYIAPYSSRPKSVVVPSESTVEIKIAGDQSSL--LILDGQYEYKISKGDTVEISKS 244
ppnK PRK03708
NAD(+) kinase;
159-401 6.60e-27

NAD(+) kinase;


Pssm-ID: 179635 [Multi-domain]  Cd Length: 277  Bit Score: 109.03  E-value: 6.60e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 159 KKFCTFRE-DYDDISN-QIDFIICLGGDGTLLYASSLFQGSVpPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVvl 236
Cdd:PRK03708   40 EHLPEFSEeDVLPLEEmDVDFIIAIGGDGTILRIEHKTKKDI-PILGINMGTLGFLTEVEPEETFFALSRLLEGDYFI-- 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 237 RSRLKVRVvkelrgkktaVHNglGENGSQAagldmdvgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGV 316
Cdd:PRK03708  117 DERIKLRV----------YIN--GENVPDA----------------LNEVVILTGIPGKIIHLKYYVDGELADEVRADGL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 317 IVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEARNtAWVSFDGRKRQEIRHGDSI 396
Cdd:PRK03708  169 IISTPTGSTAYAMSAGGPFVDPRLDAILIAPLCPFKLSSRPMVVPSSSRIDVKLLRTGRE-IILVIDGQYYEELPPDTEI 247


                  ....*
gi 2462512927 397 SITTS 401
Cdd:PRK03708  248 TIKKS 252
ppnK PRK02645
NAD(+) kinase;
172-427 2.04e-24

NAD(+) kinase;


Pssm-ID: 179455 [Multi-domain]  Cd Length: 305  Bit Score: 102.68  E-value: 2.04e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 172 SNQIDFIICLGGDGTLLYAS-SLFQGSVPpVMAFHLG-SLGFLT-PFSFENFQSQVTQVIEGNAAVVLRSRLKVRVvkeL 248
Cdd:PRK02645   55 SELIDLAIVLGGDGTVLAAArHLAPHDIP-ILSVNVGgHLGFLThPRDLLQDESVWDRLQEDRYAIERRMMLQARV---F 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 249 RGKKTavhnglgengsqaagldmDVGKQAMQYQVLNE-----VVIDRGPSSYLsnvDVYLDGHLITTVQGDGVIVSTPTG 323
Cdd:PRK02645  131 EGDRS------------------NEEPVSESYYALNDfylkpASEDRSPTCIL---ELEIDGEVVDQYQGDGLIVSTPTG 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 324 STAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAG--VELKIMLSPEARNTAWVsfDGRKRQEIRHGDSISITTS 401
Cdd:PRK02645  190 STAYTMAAGGPILHPGIDAIIVTPICPMSLSSRPIVIPPGsrVVIWPLGDYDLNIKLWK--DGVLATSIWPGQRCVIQKA 267

                         250       260
                  ....*....|....*....|....*.
gi 2462512927 402 CYPLPSICVRDPVSdWFESLAQCLHW 427
Cdd:PRK02645  268 RHPAKFIILEESYS-YYRTLREKLHW 292
pnk PRK14077
NAD(+) kinase;
169-427 2.94e-24

NAD(+) kinase;


Pssm-ID: 172567 [Multi-domain]  Cd Length: 287  Bit Score: 101.78  E-value: 2.94e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 169 DDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKEl 248
Cdd:PRK14077   59 DELFKISDFLISLGGDGTLISLCRKAAEYDKFVLGIHAGHLGFLTDITVDEAEKFFQAFFQGEFEIEKPYMLSVFLEKK- 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 249 RGKktavhnglgengsqaagldmdvgkqAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYA 328
Cdd:PRK14077  138 QGK-------------------------ILEKLAFNDVVISKNNQASMAHIEAFLNEKYFNEYFGDGVIVATPAGSTAYN 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 329 AAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMlspeARNTAWVSFDGRKRQEIRHGDSISITTScyPLPSI 408
Cdd:PRK14077  193 MSANGPIIYPLSQVFILTPVCSHSLTQRPIVLPKGFEVEFK----TKSDCILCIDGQDRYKMNDFKSIKVGLS--DKNVA 266

                         250
                  ....*....|....*....
gi 2462512927 409 CVRDPVSDWFESLAQCLHW 427
Cdd:PRK14077  267 LIRHKNRDYFQILKEKLHW 285
ppnK PRK03378
inorganic polyphosphate/ATP-NAD kinase; Provisional
 109-405 1.45e-23

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235122 [Multi-domain]  Cd Length: 292  Bit Score: 100.02  E-value: 1.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 109 VIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEDPAIaSDESFGavkkkfctfreDYDDISNQIDFIICLGGDGTLL 188
Cdd:PRK03378   10 IVGHPRHPTALTTHEMLYHWLTSKGYEVIVEQQIAHELQL-KNVKTG-----------TLAEIGQQADLAIVVGGDGNML 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 189 YAS---SLFQGSVPPVmafHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKelrgkktavHNGLGENGSq 265
Cdd:PRK03378   78 GAArvlARYDIKVIGI---NRGNLGFLTDLDPDNALQQLSDVLEGHYISEKRFLLEAQVCR---------HGQQKRIST- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 266 aagldmdvgkqamqyqVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMI 345
Cdd:PRK03378  145 ----------------AINEVVLHPGKVAHMIEFEVYIDDNFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPSLDAITL 208

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 346 TPICPHSLSFRPIVVPAGVELKIMLSPEaRNTAWVSFDGRKRQEIRHGDSISITTSCYPL 405
Cdd:PRK03378  209 VPMFPHTLSARPLVIDSSSTIRLKFSPN-RSDLEISCDSQIALPIQPGEEVLIRRSDYHL 267
ppnK PRK02649
NAD(+) kinase;
175-427 4.10e-19

NAD(+) kinase;


Pssm-ID: 179456 [Multi-domain]  Cd Length: 305  Bit Score: 87.34  E-value: 4.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 175 IDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVvkeLRGKKTa 254
Cdd:PRK02649   69 MKFAIVLGGDGTVLSAARQLAPCGIPLLTINTGHLGFLTEAYLNQLDEAIDQVLAGQYTIEERTMLTVSV---MRGDQL- 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 255 vhngLGENGSqaagldmdvgkqamqyqvLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGAS 334
Cdd:PRK02649  145 ----RWEALS------------------LNEMVLHREPLTSMCHFEIAIGRHAPVDIAADGVILSTPTGSTAYSLSAGGP 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 335 MIHPNVPAIMITPICPHSLSFRPIVVPAGVELKImlSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDPv 414
Cdd:PRK02649  203 VITPDVPVLQLTPICPHSLASRALVFSDSEPVTV--FPATPERLVMVVDGNAGCYVWPEDRVLIRRSPYPVRFIRLQDP- 279

                         250
                  ....*....|...
gi 2462512927 415 sDWFESLAQCLHW 427
Cdd:PRK02649  280 -EFFRVLREKLGW 291
ppnK PRK02231
NAD(+) kinase;
129-427 3.44e-16

NAD(+) kinase;


Pssm-ID: 167337 [Multi-domain]  Cd Length: 272  Bit Score: 78.31  E-value: 3.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 129 LMEENMIVYVEKKVledpAIASDESFGAVKkkfctfreDYDDISNQIDFIICLGGDGTLL-YASSLFQGSVPpVMAFHLG 207
Cdd:PRK02231    9 LKERGYQVLVEKEI----AEQLNLPENHLA--------SLEEIGQRAQLAIVIGGDGNMLgRARVLAKYDIP-LIGINRG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 208 SLGFLTPFSFENFQSQVTQVIE-GNAAVVLRSRLKVRVvkELRGKKTAVHNGLgengsqaagldmdvgkqamqyqvlNEV 286
Cdd:PRK02231   76 NLGFLTDIDPKNAYEQLEACLErGEFFVEERFLLEAKI--ERNGKIIATSNAL------------------------NEV 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 287 VIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVEL 366
Cdd:PRK02231  130 VIHPAKIAHMIDFHVYIDDKFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPNLNAIALVPMFPHTLSSRPLVIDGDSKI 209

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462512927 367 KIMLSPEARNTAWVSFDGRKRQEIRHGDSISITTSCYPLPSICVRDpvSDWFESLAQCLHW 427
Cdd:PRK02231  210 SLRFAEYNTPQLEVSCDSQIALPFTPDDRVHVQKSPDKLRLLHLKN--YNYYNVLSSKLGW 268
pnk PRK14075
NAD(+) kinase;
175-361 1.24e-15

NAD(+) kinase;


Pssm-ID: 184489 [Multi-domain]  Cd Length: 256  Bit Score: 76.31  E-value: 1.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 175 IDFIICLGGDGTLLYASSLFQGsvpPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKelrgkkta 254
Cdd:PRK14075   42 ADLIIVVGGDGTVLKAAKKVGT---PLVGFKAGRLGFLSSYTLEEIDRFLEDLKNWNFREEKRWFLKIESEL-------- 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 255 vhnglgengsqaagldmdvgkqaMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGAS 334
Cdd:PRK14075  111 -----------------------GNHLALNDVTLERDPSQKMVEIEVSFEDHSSMWFFADGVVISTPTGSTAYSLSLGGP 167

                         170       180
                  ....*....|....*....|....*..
gi 2462512927 335 MIHPNVPAIMITPICPHSLSFRPIVVP 361
Cdd:PRK14075  168 IILPNCEVFEITPIAPQFLATRSIVIP 194
NAD_kinase pfam01513
ATP-NAD kinase N-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, ...
 107-229 1.68e-15

ATP-NAD kinase N-terminal domain; Members of this family include ATP-NAD kinases EC:2.7.1.23, which catalyzes the phosphorylation of NAD to NADP utilizing ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus. Also includes NADH kinases EC:2.7.1.86.


Pssm-ID: 426300 [Multi-domain]  Cd Length: 128  Bit Score: 72.78  E-value: 1.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 107 VLVIKKMRDASLLQPFKELCTHLMEENMI-VYVEKKVLEDPAIASDESFGAVKKKFCTFREDYDDISNQI----DFIICL 181
Cdd:pfam01513   1 VGIVVNPDKKEALERAREVARWLLDRLGItVTVEEKMGESLAFAAGDRPEVIGCLKKVVDDTRRATRAFAdagvDLIIVL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2462512927 182 GGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIE 229
Cdd:pfam01513  81 GGDGTALRAARLLQKAVIPILGVNTGVLGFLTEFEPEAAFELLERLLE 128
ppnK PRK03372
inorganic polyphosphate/ATP-NAD kinase; Provisional
 142-405 1.46e-13

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235121 [Multi-domain]  Cd Length: 306  Bit Score: 71.10  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 142 VLEDPAIASDESFGAV---KKKFCTFREDyDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFE 218
Cdd:PRK03372   38 RVLDAEAVDLGATHPApddFRAMEVVDAD-PDAADGCELVLVLGGDGTILRAAELARAADVPVLGVNLGHVGFLAEAEAE 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 219 NFQSQVTQVIEGNAAVVLRSRLKVRVvkelRGKKTAVHNGLGengsqaagldmdvgkqamqyqvLNEVVIDRGPSSYLSN 298
Cdd:PRK03372  117 DLDEAVERVVDRDYRVEERMTLDVTV----RVGGEIVWRGWA----------------------LNEASLEKADREGMLE 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 299 VDVYLDGHLITTVQGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICPHSLSFRPIVVPAGVELKIMLSPEArNTA 378
Cdd:PRK03372  171 VVLEVDGRPVSSFGCDGVLVSTPTGSTAYAFSAGGPVVWPDLEALLVVPLNAHALFARPLVVSPTSTVAVEILADT-SDA 249

                         250       260
                  ....*....|....*....|....*..
gi 2462512927 379 WVSFDGRKRQEIRHGDSISITTSCYPL 405
Cdd:PRK03372  250 VLWCDGRRSVDLPPGARVEVRRGATPV 276
ppnK PRK04885
inorganic polyphosphate/ATP-NAD kinase; Provisional
 158-398 8.58e-11

inorganic polyphosphate/ATP-NAD kinase; Provisional


Pssm-ID: 235317 [Multi-domain]  Cd Length: 265  Bit Score: 62.14  E-value: 8.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 158 KKKFCTFREDYDDisNQIDFIICLGGDGTLLYASSLFQGSVPPVmAF---HLGSLGFLT---PFSFENFqsqVTQVIEGN 231
Cdd:PRK04885   21 KKYLKDFGFILDE--KNPDIVISVGGDGTLLSAFHRYENQLDKV-RFvgvHTGHLGFYTdwrPFEVDKL---VIALAKDP 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 232 AAVVLRSRLKVRVVKElrgkktavhnglgeNGSQAAgldmdvgkqamqYQVLNEVVIDRgPSSYLSnVDVYLDGHLITTV 311
Cdd:PRK04885   95 GQVVSYPLLEVKITYE--------------DGEKEK------------YLALNEATIKR-IEGTLV-ADVYINGVLFERF 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 312 QGDGVIVSTPTGSTAYAAAAGASMIHPNVPAIMITPICphSLS---FR----PIVVPAGVelKIMLSPEARNTAWVSFDg 384
Cdd:PRK04885  147 RGDGLCVSTPTGSTAYNKSLGGAVLHPSIEALQLTEIA--SINnrvFRtlgsPLILPKHH--TITLKPVNDDDYQITVD- 221

                         250
                  ....*....|....
gi 2462512927 385 rkRQEIRHGDSISI 398
Cdd:PRK04885  222 --HLTIKHKNVKSI 233
ppnK PRK04761
inorganic polyphosphate/ATP-NAD kinase; Reviewed
 168-321 3.04e-04

inorganic polyphosphate/ATP-NAD kinase; Reviewed


Pssm-ID: 179876 [Multi-domain]  Cd Length: 246  Bit Score: 42.11  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 168 YDDIS-NQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFL-TPFSFENFQSQVtqviegNAAVVLRSRLKVRVV 245
Cdd:PRK04761   18 YGDVPiEEADVIVALGGDGFMLQTLHRYMNSGKPVYGMNRGSVGFLmNEYSEDDLLERI------AAAEPTVLHPLRMTA 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 246 KELRGKktaVHNGLGEN-------GSQAAGLDMDV-GKQAMQyqvlnEVVidrgpssylsnvdvyldghlittvqGDGVI 317
Cdd:PRK04761   92 TDVSGE---VHEALAINevslfrqTRQAAKLRISIdGKVRME-----ELV-------------------------CDGVL 138


                  ....
gi 2462512927 318 VSTP 321
Cdd:PRK04761  139 VATP 142
ppnK PRK03501
NAD kinase;
276-322 3.18e-03

NAD kinase;


Pssm-ID: 179584  Cd Length: 264  Bit Score: 39.19  E-value: 3.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 2462512927 276 QAMQYQVLNEVVIDrgpSSYLSN--VDVYLDGHLITTVQGDGVIVSTPT 322
Cdd:PRK03501  113 GSTSFYCLNEFSIR---SSIIKTfvIDVYIDDLHFETFRGDGMVVSTPT 158
PLN02929 PLN02929
NADH kinase
 162-244 3.20e-03

NADH kinase


Pssm-ID: 215502 [Multi-domain]  Cd Length: 301  Bit Score: 39.25  E-value: 3.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 162 CTFREDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPvmafhLG----------------------SLGFLTPFSFEN 219
Cdd:PLN02929   52 CVLRNELSQPIRDVDLVVAVGGDGTLLQASHFLDDSIPV-----LGvnsdptqkdeveeysdefdarrSTGHLCAATAED 126

                          90       100
                  ....*....|....*....|....*
gi 2462512927 220 FQSQVTQVIEGNAAVVLRSRLKVRV 244
Cdd:PLN02929  127 FEQVLDDVLFGRLKPTELSRISTVV 151
ppnK PRK00561
NAD(+) kinase;
173-398 8.59e-03

NAD(+) kinase;


Pssm-ID: 100598 [Multi-domain]  Cd Length: 259  Bit Score: 37.93  E-value: 8.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 173 NQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSF----ENFQSQVTQviegnaavvlrsrLKVRVVKEL 248
Cdd:PRK00561   32 DGADYLFVLGGDGFFVSTAANYNCAGCKVVGINTGHLGFYTSFNEtdldQNFANKLDQ-------------LKFTQIDLL 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462512927 249 RgkktavhnglgengsqaagldmdVGKQAMQYQVLNEVVIDrgpSSYLSNVDVYLDGHLITTVQGDGVIVSTPTGSTAYA 328
Cdd:PRK00561   99 E-----------------------VQIDDQIHLVLNELAVY---TNTAYPINIFIDNEFWEKYRGSGLLIGPRTGSTALA 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462512927 329 AAAGASMIHPNVPAIMITPICP--HSlSF----RPIVVPAGVELKIMLSPEARNTAWVSF--DGRKRQEIRHGDSISI 398
Cdd:PRK00561  153 KSAKGAVIFPRIDVIQIIELNPllHP-NQttiqSPIILPIDTKVEFEIKKAFDHDQFPRFyaDGAKLRLGNSDTTIEI 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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