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Conserved domains on  [gi|2462513754|ref|XP_054194787|]
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dyslexia-associated protein KIAA0319-like protein isoform X6 [Homo sapiens]

Protein Classification

myxo_dep_M36 superfamily-containing protein( domain architecture ID 1906324)

myxo_dep_M36 superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
myxo_dep_M36 super family cl45606
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 405-787 5.67e-37

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


The actual alignment was detected with superfamily member NF038112:

Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 151.35  E-value: 5.67e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  405 NRPPIAIVSPQFQEisLPTTSTVIDGSQSTD-DDKIVQYHWEELKGP---LreekISEDTAilKLSKLVP-----GNYTF 475
Cdd:NF038112  1185 NRRPVANAGPDQTV--LERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtL----TGADTA--TPSFTAPevtadTVLTF 1256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  476 SLTVvdSDGATNSTTANLTVNKA-VDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGV 554
Cdd:NF038112  1257 QLVV--SDGTKTSAPDTVTVLVRnVNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWT---QTSGPAVTLTGA 1330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  555 RTPTLQLSAMQ---EGDYTYQLTVTDTIgQQATAQVTVIVQPENnKPPQADAGPDKElTLPVDSTTLDGSKSSDDQKIIS 631
Cdd:NF038112  1331 TTATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALT 1407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  632 YLWEKTQGPDgVQLENANSSVATVTGLQVG---TYVFTLTVKDERNLQSQSSVNVIVKEeINKPPIAKiTGNVVITLPTS 708
Cdd:NF038112  1408 YAWTQTAGPT-VTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRN-VNRAPVAH-AGESITVDEGS 1484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  709 TAELDGSKSSDDKGIVSYLWTRDEGSPAAgevLNHSDHHPILFLSNLVEG--TYTFHLKVTDAKGESDTDRTTVEVKPDP 786
Cdd:NF038112  1485 TVTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVN 1561


                   .
gi 2462513754  787 R 787
Cdd:NF038112  1562 R 1562
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 405-787 5.67e-37

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 151.35  E-value: 5.67e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  405 NRPPIAIVSPQFQEisLPTTSTVIDGSQSTD-DDKIVQYHWEELKGP---LreekISEDTAilKLSKLVP-----GNYTF 475
Cdd:NF038112  1185 NRRPVANAGPDQTV--LERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtL----TGADTA--TPSFTAPevtadTVLTF 1256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  476 SLTVvdSDGATNSTTANLTVNKA-VDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGV 554
Cdd:NF038112  1257 QLVV--SDGTKTSAPDTVTVLVRnVNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWT---QTSGPAVTLTGA 1330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  555 RTPTLQLSAMQ---EGDYTYQLTVTDTIgQQATAQVTVIVQPENnKPPQADAGPDKElTLPVDSTTLDGSKSSDDQKIIS 631
Cdd:NF038112  1331 TTATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALT 1407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  632 YLWEKTQGPDgVQLENANSSVATVTGLQVG---TYVFTLTVKDERNLQSQSSVNVIVKEeINKPPIAKiTGNVVITLPTS 708
Cdd:NF038112  1408 YAWTQTAGPT-VTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRN-VNRAPVAH-AGESITVDEGS 1484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  709 TAELDGSKSSDDKGIVSYLWTRDEGSPAAgevLNHSDHHPILFLSNLVEG--TYTFHLKVTDAKGESDTDRTTVEVKPDP 786
Cdd:NF038112  1485 TVTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVN 1561


                   .
gi 2462513754  787 R 787
Cdd:NF038112  1562 R 1562
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 283-693 1.19e-28

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 124.38  E-value: 1.19e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  283 PSYSYATPTP---QASFQSTSAPYPVIkelvvSAGESVQItLPKNEVQLN--AYVlqePPKGETYTYDW-QLITHPRDYS 356
Cdd:NF038112  1164 LKFTGITNTPftsLVAEPGVCNRRPVA-----NAGPDQTV-LERTTVTLNgsGSF---DPDGDPLTYAWtQVSGPAVTLT 1234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  357 GEMEGKHS----QILKLSKLTpglyeFKVIV-EGQNAHGEGYVNVTVKpepRKNRPPIAivspqfqEISLPTT----STV 427
Cdd:NF038112  1235 GADTATPSftapEVTADTVLT-----FQLVVsDGTKTSAPDTVTVLVR---NVNRAPVA-------VAGAPATvderSTV 1299

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  428 -IDGSQSTDDDKIVQYHWEELKGPLREEKiseDTAILKLSKLVP---GNYTFSLTVVDSDG-ATNSTTANLTVnKAVDYP 502
Cdd:NF038112  1300 tLDGSGTDADGDALTYAWTQTSGPAVTLT---GATTATATFTAPevtADTQLTFTLTVSDGtASATDTVTVTV-RNVNRA 1375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  503 PVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPTLQLSA---MQEGDYTYQLTVTDti 579
Cdd:NF038112  1376 PVANAGADQTVD-ERSTVTLSGSATDPDGDALTYAWT---QTAGPTVTLTGADTATASFTApevAADTELTFQLTVSA-- 1449

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  580 GQQATAQVTVIVQPEN-NKPPQADAGPDKELTlPVDSTTLDGSKSSDDQKIISYLWEKTQGPdGVQLENANSSVATVTGL 658
Cdd:NF038112  1450 DGQASADVTVTVTVRNvNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWTQVAGP-SVTLTGADSAKLTFTAP 1527

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 2462513754  659 QVG---TYVFTLTVKDERNLQSQSSVNVIVKEEINKPP 693
Cdd:NF038112  1528 EVSadtTLTFSLTVTDGSGSSGPVVVTVTVKNVNRAPD 1565
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 273-600 3.63e-17

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 87.02  E-value: 3.63e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  273 TQIAVPqPVAPSySYATPTPqaSFQSTSAPYPVIK--ELVVSAGesVQITLPKN-EVQLN-------------------- 329
Cdd:NF038112  1224 TQVSGP-AVTLT-GADTATP--SFTAPEVTADTVLtfQLVVSDG--TKTSAPDTvTVLVRnvnrapvavagapatvders 1297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  330 AYVLQ---EPPKGETYTYDW-QLITHPRDYSGEMEGKHS----QILKLSKLTpglyeFKVIVEGQNAHGEGYVNVTVKPe 401
Cdd:NF038112  1298 TVTLDgsgTDADGDALTYAWtQTSGPAVTLTGATTATATftapEVTADTQLT-----FTLTVSDGTASATDTVTVTVRN- 1371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  402 prKNRPPIAIVSPQfQEISLPTTSTvIDGSQSTDDDKIVQYHWEELKGPlREEKISEDTAILKL---SKLVPGNYTFSLT 478
Cdd:NF038112  1372 --VNRAPVANAGAD-QTVDERSTVT-LSGSATDPDGDALTYAWTQTAGP-TVTLTGADTATASFtapEVAADTELTFQLT 1446

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  479 VVDSDGATNSTTANLTVNKaVDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPT 558
Cdd:NF038112  1447 VSADGQASADVTVTVTVRN-VNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWT---QVAGPSVTLTGADSAK 1521

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2462513754  559 LQLSAMQEG---DYTYQLTVTDTIGQQATAQVTVIVQPENNKPPQ 600
Cdd:NF038112  1522 LTFTAPEVSadtTLTFSLTVTDGSGSSGPVVVTVTVKNVNRAPDG 1566
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 690-780 1.62e-11

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 61.13  E-value: 1.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 690 NKPPIAKITGNVVITlPTSTAELDGSKSSD-DKGIVSYLWTRDEGSPAAGEVLNHSDHHPilflsnlveGTYTFHLKVTD 768
Cdd:pfam18911   1 NAAPVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDFGDGTTATGANVSHTYAAP---------GTYTVTLTVTD 70

                          90
                  ....*....|....*
gi 2462513754 769 AKG---ESDTDRTTV 780
Cdd:pfam18911  71 DSGasnSTATDTVTV 85
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 695-783 7.15e-07

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 47.83  E-value: 7.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  695 AKITGNVVITLPTSTAELDGSkSSDDKGIVSYLWTRDEGSPAAGEVLNHSdhhpilFLSnlvEGTYTFHLKVTDAKGeSD 774
Cdd:smart00089   2 ADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTWDFGDGTSSTGPTVTHT------YTK---PGTYTVTLTVTNAVG-SA 70


                   ....*....
gi 2462513754  775 TDRTTVEVK 783
Cdd:smart00089  71 SATVTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 693-782 1.44e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 44.02  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 693 PIAKITGNVVITLPTStAELDGSKSSDDKgIVSYLWTRDEGSPAAGEvlnhsdhHPILFLSNLVEGTYTFHLKVTDAKGE 772
Cdd:cd00146     1 PTASVSAPPVAELGAS-VTFSASDSSGGS-IVSYKWDFGDGEVSSSG-------EPTVTHTYTKPGTYTVTLTVTNAVGS 71

                          90
                  ....*....|
gi 2462513754 773 SDTDRTTVEV 782
Cdd:cd00146    72 SSTKTTTVVV 81
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
473-780 1.26e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 45.76  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 473 YTFSLTVVDSDGatNSTTANLTVNKAVDYPPVANAGPNQVITLPqNSITLFGNQSTDDhGITSYEWSLSPSSKGKVVEMQ 552
Cdd:COG3401   205 YYYRVAATDTGG--ESAPSNEVSVTTPTTPPSAPTGLTATADTP-GSVTLSWDPVTES-DATGYRVYRSNSGDGPFTKVA 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 553 GVRTPTLQLSAMQEG-DYTYQLTVTDTIGQQATAQVTVIVQPENNkPPQADAGPDKELTLPvDSTTLDGSKSSDDqKIIS 631
Cdd:COG3401   281 TVTTTSYTDTGLTNGtTYYYRVTAVDAAGNESAPSNVVSVTTDLT-PPAAPSGLTATAVGS-SSITLSWTASSDA-DVTG 357

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 632 YLWEKTQGPDGVQ---LENANSSVATVTGLQVG-TYVFTLTVKDERNLQSQSSvNVIVKEEINKPPIAKITGNVVITLPT 707
Cdd:COG3401   358 YNVYRSTSGGGTYtkiAETVTTTSYTDTGLTPGtTYYYKVTAVDAAGNESAPS-EEVSATTASAASGESLTASVDAVPLT 436

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462513754 708 STAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNHSDHHPILFLSNLVEGTYTFHLKVTDAKGESDTDRTTV 780
Cdd:COG3401   437 DVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSV 509
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 405-787 5.67e-37

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 151.35  E-value: 5.67e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  405 NRPPIAIVSPQFQEisLPTTSTVIDGSQSTD-DDKIVQYHWEELKGP---LreekISEDTAilKLSKLVP-----GNYTF 475
Cdd:NF038112  1185 NRRPVANAGPDQTV--LERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtL----TGADTA--TPSFTAPevtadTVLTF 1256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  476 SLTVvdSDGATNSTTANLTVNKA-VDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGV 554
Cdd:NF038112  1257 QLVV--SDGTKTSAPDTVTVLVRnVNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWT---QTSGPAVTLTGA 1330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  555 RTPTLQLSAMQ---EGDYTYQLTVTDTIgQQATAQVTVIVQPENnKPPQADAGPDKElTLPVDSTTLDGSKSSDDQKIIS 631
Cdd:NF038112  1331 TTATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALT 1407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  632 YLWEKTQGPDgVQLENANSSVATVTGLQVG---TYVFTLTVKDERNLQSQSSVNVIVKEeINKPPIAKiTGNVVITLPTS 708
Cdd:NF038112  1408 YAWTQTAGPT-VTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRN-VNRAPVAH-AGESITVDEGS 1484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  709 TAELDGSKSSDDKGIVSYLWTRDEGSPAAgevLNHSDHHPILFLSNLVEG--TYTFHLKVTDAKGESDTDRTTVEVKPDP 786
Cdd:NF038112  1485 TVTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVN 1561


                   .
gi 2462513754  787 R 787
Cdd:NF038112  1562 R 1562
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 283-693 1.19e-28

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 124.38  E-value: 1.19e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  283 PSYSYATPTP---QASFQSTSAPYPVIkelvvSAGESVQItLPKNEVQLN--AYVlqePPKGETYTYDW-QLITHPRDYS 356
Cdd:NF038112  1164 LKFTGITNTPftsLVAEPGVCNRRPVA-----NAGPDQTV-LERTTVTLNgsGSF---DPDGDPLTYAWtQVSGPAVTLT 1234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  357 GEMEGKHS----QILKLSKLTpglyeFKVIV-EGQNAHGEGYVNVTVKpepRKNRPPIAivspqfqEISLPTT----STV 427
Cdd:NF038112  1235 GADTATPSftapEVTADTVLT-----FQLVVsDGTKTSAPDTVTVLVR---NVNRAPVA-------VAGAPATvderSTV 1299

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  428 -IDGSQSTDDDKIVQYHWEELKGPLREEKiseDTAILKLSKLVP---GNYTFSLTVVDSDG-ATNSTTANLTVnKAVDYP 502
Cdd:NF038112  1300 tLDGSGTDADGDALTYAWTQTSGPAVTLT---GATTATATFTAPevtADTQLTFTLTVSDGtASATDTVTVTV-RNVNRA 1375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  503 PVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPTLQLSA---MQEGDYTYQLTVTDti 579
Cdd:NF038112  1376 PVANAGADQTVD-ERSTVTLSGSATDPDGDALTYAWT---QTAGPTVTLTGADTATASFTApevAADTELTFQLTVSA-- 1449

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  580 GQQATAQVTVIVQPEN-NKPPQADAGPDKELTlPVDSTTLDGSKSSDDQKIISYLWEKTQGPdGVQLENANSSVATVTGL 658
Cdd:NF038112  1450 DGQASADVTVTVTVRNvNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWTQVAGP-SVTLTGADSAKLTFTAP 1527

                          410       420       430
                   ....*....|....*....|....*....|....*...
gi 2462513754  659 QVG---TYVFTLTVKDERNLQSQSSVNVIVKEEINKPP 693
Cdd:NF038112  1528 EVSadtTLTFSLTVTDGSGSSGPVVVTVTVKNVNRAPD 1565
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 273-600 3.63e-17

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 87.02  E-value: 3.63e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  273 TQIAVPqPVAPSySYATPTPqaSFQSTSAPYPVIK--ELVVSAGesVQITLPKN-EVQLN-------------------- 329
Cdd:NF038112  1224 TQVSGP-AVTLT-GADTATP--SFTAPEVTADTVLtfQLVVSDG--TKTSAPDTvTVLVRnvnrapvavagapatvders 1297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  330 AYVLQ---EPPKGETYTYDW-QLITHPRDYSGEMEGKHS----QILKLSKLTpglyeFKVIVEGQNAHGEGYVNVTVKPe 401
Cdd:NF038112  1298 TVTLDgsgTDADGDALTYAWtQTSGPAVTLTGATTATATftapEVTADTQLT-----FTLTVSDGTASATDTVTVTVRN- 1371

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  402 prKNRPPIAIVSPQfQEISLPTTSTvIDGSQSTDDDKIVQYHWEELKGPlREEKISEDTAILKL---SKLVPGNYTFSLT 478
Cdd:NF038112  1372 --VNRAPVANAGAD-QTVDERSTVT-LSGSATDPDGDALTYAWTQTAGP-TVTLTGADTATASFtapEVAADTELTFQLT 1446

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  479 VVDSDGATNSTTANLTVNKaVDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPT 558
Cdd:NF038112  1447 VSADGQASADVTVTVTVRN-VNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWT---QVAGPSVTLTGADSAK 1521

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2462513754  559 LQLSAMQEG---DYTYQLTVTDTIGQQATAQVTVIVQPENNKPPQ 600
Cdd:NF038112  1522 LTFTAPEVSadtTLTFSLTVTDGSGSSGPVVVTVTVKNVNRAPDG 1566
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 690-780 1.62e-11

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 61.13  E-value: 1.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 690 NKPPIAKITGNVVITlPTSTAELDGSKSSD-DKGIVSYLWTRDEGSPAAGEVLNHSDHHPilflsnlveGTYTFHLKVTD 768
Cdd:pfam18911   1 NAAPVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDFGDGTTATGANVSHTYAAP---------GTYTVTLTVTD 70

                          90
                  ....*....|....*
gi 2462513754 769 AKG---ESDTDRTTV 780
Cdd:pfam18911  71 DSGasnSTATDTVTV 85
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 695-783 7.15e-07

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 47.83  E-value: 7.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  695 AKITGNVVITLPTSTAELDGSkSSDDKGIVSYLWTRDEGSPAAGEVLNHSdhhpilFLSnlvEGTYTFHLKVTDAKGeSD 774
Cdd:smart00089   2 ADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTWDFGDGTSSTGPTVTHT------YTK---PGTYTVTLTVTNAVG-SA 70


                   ....*....
gi 2462513754  775 TDRTTVEVK 783
Cdd:smart00089  71 SATVTVVVQ 79
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 502-589 1.95e-06

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 46.49  E-value: 1.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 502 PPVANAGPNQVITLPQnSITLFGNQSTD-DHGITSYEWSLS--PSSKGKVVemqgVRTPTlqlsamQEGDYTYQLTVTDT 578
Cdd:pfam18911   3 APVADAGGDRIVAEGE-TVTFDASASDDpDGDILSYRWDFGdgTTATGANV----SHTYA------APGTYTVTLTVTDD 71

                          90
                  ....*....|....
gi 2462513754 579 IGQQ---ATAQVTV 589
Cdd:pfam18911  72 SGASnstATDTVTV 85
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 596-685 2.59e-06

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 46.11  E-value: 2.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 596 NKPPQADAGPDKELTlPVDSTTLDGSKSSD-DQKIISYLWEKtqgPDGvqlenanssvATVTGLQV-------GTYVFTL 667
Cdd:pfam18911   1 NAAPVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDF---GDG----------TTATGANVshtyaapGTYTVTL 66

                          90
                  ....*....|....*...
gi 2462513754 668 TVKDERNLQSQSSVNVIV 685
Cdd:pfam18911  67 TVTDDSGASNSTATDTVT 84
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 504-592 8.68e-06

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 44.75  E-value: 8.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  504 VANAGPNQVITLPQNSITlFGNQSTDDHGITSYEWSLS--PSSKGKVVEMQGVRtptlqlsamqEGDYTYQLTVTDTIGq 581
Cdd:smart00089   1 VADVSASPTVGVAGESVT-FTATSSDDGSIVSYTWDFGdgTSSTGPTVTHTYTK----------PGTYTVTLTVTNAVG- 68

                           90
                   ....*....|.
gi 2462513754  582 QATAQVTVIVQ 592
Cdd:smart00089  69 SASATVTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 693-782 1.44e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 44.02  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 693 PIAKITGNVVITLPTStAELDGSKSSDDKgIVSYLWTRDEGSPAAGEvlnhsdhHPILFLSNLVEGTYTFHLKVTDAKGE 772
Cdd:cd00146     1 PTASVSAPPVAELGAS-VTFSASDSSGGS-IVSYKWDFGDGEVSSSG-------EPTVTHTYTKPGTYTVTLTVTNAVGS 71

                          90
                  ....*....|
gi 2462513754 773 SDTDRTTVEV 782
Cdd:cd00146    72 SSTKTTTVVV 81
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 503-591 5.86e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 42.48  E-value: 5.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 503 PVANAGPNQVITLPQnSITLFGNqSTDDHGITSYEWSLSpsskGKVVEMQGVRTPTLqlSAMQEGDYTYQLTVTDTIGQQ 582
Cdd:cd00146     1 PTASVSAPPVAELGA-SVTFSAS-DSSGGSIVSYKWDFG----DGEVSSSGEPTVTH--TYTKPGTYTVTLTVTNAVGSS 72


                  ....*....
gi 2462513754 583 ATAQVTVIV 591
Cdd:cd00146    73 STKTTTVVV 81
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 601-686 5.98e-05

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 42.44  E-value: 5.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  601 ADAGPDKELTLPVDSTTLDGSkSSDDQKIISYLWekTQGpDGVQLENANssvATVTGLQVGTYVFTLTVKDErNLQSQSS 680
Cdd:smart00089   2 ADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTW--DFG-DGTSSTGPT---VTHTYTKPGTYTVTLTVTNA-VGSASAT 73


                   ....*.
gi 2462513754  681 VNVIVK 686
Cdd:smart00089  74 VTVVVQ 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
473-780 1.26e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 45.76  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 473 YTFSLTVVDSDGatNSTTANLTVNKAVDYPPVANAGPNQVITLPqNSITLFGNQSTDDhGITSYEWSLSPSSKGKVVEMQ 552
Cdd:COG3401   205 YYYRVAATDTGG--ESAPSNEVSVTTPTTPPSAPTGLTATADTP-GSVTLSWDPVTES-DATGYRVYRSNSGDGPFTKVA 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 553 GVRTPTLQLSAMQEG-DYTYQLTVTDTIGQQATAQVTVIVQPENNkPPQADAGPDKELTLPvDSTTLDGSKSSDDqKIIS 631
Cdd:COG3401   281 TVTTTSYTDTGLTNGtTYYYRVTAVDAAGNESAPSNVVSVTTDLT-PPAAPSGLTATAVGS-SSITLSWTASSDA-DVTG 357

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 632 YLWEKTQGPDGVQ---LENANSSVATVTGLQVG-TYVFTLTVKDERNLQSQSSvNVIVKEEINKPPIAKITGNVVITLPT 707
Cdd:COG3401   358 YNVYRSTSGGGTYtkiAETVTTTSYTDTGLTPGtTYYYKVTAVDAAGNESAPS-EEVSATTASAASGESLTASVDAVPLT 436

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462513754 708 STAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNHSDHHPILFLSNLVEGTYTFHLKVTDAKGESDTDRTTV 780
Cdd:COG3401   437 DVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSV 509
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 460-693 1.70e-04

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 45.18  E-value: 1.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 460 TAILKLSKLVPGNYTFSLTVVDSDGATNSTTANLTVN-KAVDYPPVANAGPNQVITLpQNSITLFGNQSTD------DHG 532
Cdd:pfam02010  42 QLTIPSGTLPYGTYVFTLTVSLSSTPSLAGTDIITVTvQPSPLVAVIDGGSSRVVGY-NQDLTLDGSESYDpdvdpgSSS 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 533 ITSYEWS---------LSPSSKGKVVE------MQGVRTPTLQLSA-MQEGDYTYQ--LTVTDTIGQQATAQVTVIVQPE 594
Cdd:pfam02010 121 GLTYLWScrrsssgdnPLLNNDPVCFSdqnegtLLQSTSSSLTIPAsTLQANVTYTfkLTVSKGSRNSASTTQTILVVDG 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 595 NnkPPQAD---AGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEK----TQGPDGVQLENANSSVATVTG---------- 657
Cdd:pfam02010 201 N--PPIIIlscISNCNRKNNPVDRLVLLASTCLNCSSDLSDVTYRwlslGSENTSLVLDQLNSQTSTGRSgpylvikagv 278

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2462513754 658 LQVGT-YVFTLTVKDeRNLQSQSSVNVIVKeeINKPP 693
Cdd:pfam02010 279 LQSGVsYRFTLIVTV-YPGLVSGLASISFI--TNAPP 312
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
470-742 1.93e-04

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 44.66  E-value: 1.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 470 PGNYTFSLTVVDSDGATNSTTANLTVNKAVDYPPVANAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPSSKGkvv 549
Cdd:COG3291    49 PGTYTVTLTVTDAAGCSDTTTKTITVGAPNPGVTTVTTSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPG--- 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 550 emQGVRTPTLQLSAMQEGDYTYQLTVTDTIGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSSDDQKI 629
Cdd:COG3291   126 --GGGGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTV 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 630 ISYLWEKTQGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEINKPPIAKITGNVVITLPTST 709
Cdd:COG3291   204 TSGTAGVTTGATSGTSGTGSATSGVAVTDVTLTGISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTN 283

                         250       260       270
                  ....*....|....*....|....*....|...
gi 2462513754 710 AELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLN 742
Cdd:COG3291   284 GTGGLGTTTAITPGNVSTTADVTGGTATLAVSS 316
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 410-495 2.65e-04

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 40.51  E-value: 2.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754  410 AIVSPQFQEISLPTTSTVIDgsQSTDDDKIVQYHWEELKGPLREEKisedTAILKLSKlvPGNYTFSLTVVDSDGaTNST 489
Cdd:smart00089   2 ADVSASPTVGVAGESVTFTA--TSSDDGSIVSYTWDFGDGTSSTGP----TVTHTYTK--PGTYTVTLTVTNAVG-SASA 72


                   ....*.
gi 2462513754  490 TANLTV 495
Cdd:smart00089  73 TVTVVV 78
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 623-685 3.01e-04

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 40.17  E-value: 3.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462513754 623 SSDDQKIISYLWekTQGPDGVQLENAnsSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIV 685
Cdd:cd00146    23 DSSGGSIVSYKW--DFGDGEVSSSGE--PTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTTVVV 81
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 405-495 3.65e-03

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 37.25  E-value: 3.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462513754 405 NRPPIAIVSPQfqEISLPTTSTVIDGSQSTDDD-KIVQYHWEelkgplreekiSEDTAILKLSKLV-----PGNYTFSLT 478
Cdd:pfam18911   1 NAAPVADAGGD--RIVAEGETVTFDASASDDPDgDILSYRWD-----------FGDGTTATGANVShtyaaPGTYTVTLT 67

                          90
                  ....*....|....*...
gi 2462513754 479 VVDSDGATNST-TANLTV 495
Cdd:pfam18911  68 VTDDSGASNSTaTDTVTV 85
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 431-495 6.16e-03

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 36.71  E-value: 6.16e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462513754 431 SQSTDDDKIVQYHWEELKGPLreekISEDTAILKLSKLVPGNYTFSLTVVDSDGATNSTTANLTV 495
Cdd:cd00146    21 ASDSSGGSIVSYKWDFGDGEV----SSSGEPTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTTVVV 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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