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Conserved domains on  [gi|2462570255|ref|XP_054196576|]
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transcription termination factor 4, mitochondrial isoform X1 [Homo sapiens]

Protein Classification

mTERF domain-containing protein( domain architecture ID 139977)

mTERF (mitochondrial transcription termination factor) domain-containing protein may function as a transcription termination factor that binds promoter DNA and regulates mitochondrial replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
mTERF super family cl47744
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 91-192 1.84e-03

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


The actual alignment was detected with superfamily member pfam02536:

Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 38.74  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570255  91 ELERVMSSLLDMGFSNAHINELLSvRR----GASLQQLLDIISEFIL-LGLNPEPVCVVLKKSPQLLKLPIMQMRKRSSY 165
Cdd:pfam02536 145 TFEEKVEFLKELGFSVEDVWKIIK-KCpeilGLSIEKKLKKKIEFLKkCGLSEEELPRVIKKYPQILSLSERTILNRVEF 223

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2462570255 166 LQKLGL--GEAAS---------SYSV-TAKKKTFVLQKK 192
Cdd:pfam02536 224 LLGLGFskEEVAKmvkrfpqllGLSIeVLKPKLEFLVKE 262
 
Name Accession Description Interval E-value
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 91-192 1.84e-03

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 38.74  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570255  91 ELERVMSSLLDMGFSNAHINELLSvRR----GASLQQLLDIISEFIL-LGLNPEPVCVVLKKSPQLLKLPIMQMRKRSSY 165
Cdd:pfam02536 145 TFEEKVEFLKELGFSVEDVWKIIK-KCpeilGLSIEKKLKKKIEFLKkCGLSEEELPRVIKKYPQILSLSERTILNRVEF 223

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2462570255 166 LQKLGL--GEAAS---------SYSV-TAKKKTFVLQKK 192
Cdd:pfam02536 224 LLGLGFskEEVAKmvkrfpqllGLSIeVLKPKLEFLVKE 262
 
Name Accession Description Interval E-value
mTERF pfam02536
mTERF; This family contains one sequence of known function Human mitochondrial transcription ...
 91-192 1.84e-03

mTERF; This family contains one sequence of known function Human mitochondrial transcription termination factor (mTERF) the rest of the family consists of hypothetical proteins none of which have any functional information. mTERF is a multizipper protein possessing three putative leucine zippers one of which is bipartite. The protein binds DNA as a monomer. The leucine zippers are not implicated in a dimerization role as in other leucine zippers.


Pssm-ID: 460581 [Multi-domain]  Cd Length: 313  Bit Score: 38.74  E-value: 1.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570255  91 ELERVMSSLLDMGFSNAHINELLSvRR----GASLQQLLDIISEFIL-LGLNPEPVCVVLKKSPQLLKLPIMQMRKRSSY 165
Cdd:pfam02536 145 TFEEKVEFLKELGFSVEDVWKIIK-KCpeilGLSIEKKLKKKIEFLKkCGLSEEELPRVIKKYPQILSLSERTILNRVEF 223

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2462570255 166 LQKLGL--GEAAS---------SYSV-TAKKKTFVLQKK 192
Cdd:pfam02536 224 LLGLGFskEEVAKmvkrfpqllGLSIeVLKPKLEFLVKE 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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