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Conserved domains on  [gi|2462570407|ref|XP_054196650|]
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ankyrin and armadillo repeat-containing protein isoform X8 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
526-696 2.68e-18

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.93  E-value: 2.68e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  526 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRrfvtFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWM 605
Cdd:COG0666     80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR----DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  606 PIHFAAFYDNVCIIIAlcrkdpsLLEA----EATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVL 681
Cdd:COG0666    156 PLHLAAANGNLEIVKL-------LLEAgadvNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAE 228

                          170
                   ....*....|....*
gi 2462570407  682 TFHTEVLKYIIKLNI 696
Cdd:COG0666    229 NGNLEIVKLLLEAGA 243
PLN03200 super family cl33659
cellulose synthase-interactive protein; Provisional
 744-949 2.56e-06

cellulose synthase-interactive protein; Provisional


The actual alignment was detected with superfamily member PLN03200:

Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 52.41  E-value: 2.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  744 IPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCENKD-----V 818
Cdd:PLN03200    60 MPLLVSLLRSGTLGAKVNAAAVLGVLCKEEDLRVKVLLGGCIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDhvgskI 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  819 IAKYNGIPSLINLLN--LNIENVLVN-VMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSD--------SGLFNLFLNS 887
Cdd:PLN03200   140 FSTEGVVPSLWDQLQpgNKQDKVVEGlLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGnsdaqanaASLLARLMMA 219

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462570407  888 FEDVLKAVSSAaiaevgrdnkeiqdaiameGAIPPLVALF-KGKQISVQMKGAMAVESLASHN 949
Cdd:PLN03200   220 FESSISKVLDA-------------------GAVKQLLKLLgQGNEVSVRAEAAGALEALSSQS 263
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
526-696 2.68e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.93  E-value: 2.68e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  526 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRrfvtFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWM 605
Cdd:COG0666     80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR----DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  606 PIHFAAFYDNVCIIIAlcrkdpsLLEA----EATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVL 681
Cdd:COG0666    156 PLHLAAANGNLEIVKL-------LLEAgadvNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAE 228

                          170
                   ....*....|....*
gi 2462570407  682 TFHTEVLKYIIKLNI 696
Cdd:COG0666    229 NGNLEIVKLLLEAGA 243
Ank_2 pfam12796
Ankyrin repeats (3 copies);
574-669 1.68e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.89  E-value: 1.68e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  574 LHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEaeataENQCTPLLLAATSGALD 653
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK-----DNGRTALHYAARSGHLE 75

                           90
                   ....*....|....*.
gi 2462570407  654 TIQYLFSIGANWRKTD 669
Cdd:pfam12796   76 IVKLLLEKGADINVKD 91
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 744-949 2.56e-06

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 52.41  E-value: 2.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  744 IPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCENKD-----V 818
Cdd:PLN03200    60 MPLLVSLLRSGTLGAKVNAAAVLGVLCKEEDLRVKVLLGGCIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDhvgskI 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  819 IAKYNGIPSLINLLN--LNIENVLVN-VMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSD--------SGLFNLFLNS 887
Cdd:PLN03200   140 FSTEGVVPSLWDQLQpgNKQDKVVEGlLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGnsdaqanaASLLARLMMA 219

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462570407  888 FEDVLKAVSSAaiaevgrdnkeiqdaiameGAIPPLVALF-KGKQISVQMKGAMAVESLASHN 949
Cdd:PLN03200   220 FESSISKVLDA-------------------GAVKQLLKLLgQGNEVSVRAEAAGALEALSSQS 263
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 731-771 1.87e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 42.83  E-value: 1.87e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462570407  731 NDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSNIST 771
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
686-848 2.37e-05

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 48.73  E-value: 2.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  686 EVLKYIIKLNIPelpvwKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGL 765
Cdd:COG5064    276 EKIQAVLDVGIP-----GRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWT 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  766 LSNIST-HKSAVHALVEAGGIPSLINLLVCDEPEVHSR-CAVILYDIAQCENKDVIAKY---NG-IPSLINLLNLNIENV 839
Cdd:COG5064    351 ISNITAgNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEaCWAISNATSGGLNRPDIIRYlvsQGfIKPLCDLLDVVDNKI 430


                   ....*....
gi 2462570407  840 LVNVMNCIR 848
Cdd:COG5064    431 IEVALDAIE 439
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 738-770 1.05e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 40.88  E-value: 1.05e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2462570407   738 ILDAGTIPALINLLKSSKIKLQCKTVGLLSNIS 770
Cdd:smart00185    8 VVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 537-664 2.66e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.98  E-value: 2.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  537 FHHAALHNRVSIICQLCNANFKVNQrrfVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNV 616
Cdd:PHA02875    72 LHDAVEEGDVKAVEELLDLGKFADD---VFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462570407  617 CIIialcrkdPSLLEAEATAENQ----CTPLLLAATSGALDTIQYLFSIGAN 664
Cdd:PHA02875   149 KGI-------ELLIDHKACLDIEdccgCTPLIIAMAKGDIAICKMLLDSGAN 193
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
526-696 2.68e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.93  E-value: 2.68e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  526 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRrfvtFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWM 605
Cdd:COG0666     80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR----DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  606 PIHFAAFYDNVCIIIAlcrkdpsLLEA----EATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVL 681
Cdd:COG0666    156 PLHLAAANGNLEIVKL-------LLEAgadvNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAE 228

                          170
                   ....*....|....*
gi 2462570407  682 TFHTEVLKYIIKLNI 696
Cdd:COG0666    229 NGNLEIVKLLLEAGA 243
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
526-696 1.76e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 78.46  E-value: 1.76e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  526 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRfvtfSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWM 605
Cdd:COG0666    113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQD----NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGET 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  606 PIHFAAFYDNVCIIIALCRK--DPslleaEATAENQCTPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTF 683
Cdd:COG0666    189 PLHLAAENGHLEIVKLLLEAgaDV-----NAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAG 263

                          170
                   ....*....|...
gi 2462570407  684 HTEVLKYIIKLNI 696
Cdd:COG0666    264 AALIVKLLLLALL 276
Ank_2 pfam12796
Ankyrin repeats (3 copies);
574-669 1.68e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.89  E-value: 1.68e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  574 LHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDPSLLEaeataENQCTPLLLAATSGALD 653
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK-----DNGRTALHYAARSGHLE 75

                           90
                   ....*....|....*.
gi 2462570407  654 TIQYLFSIGANWRKTD 669
Cdd:pfam12796   76 IVKLLLEKGADINVKD 91
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 744-949 2.56e-06

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 52.41  E-value: 2.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  744 IPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVEAGGIPSLINLLVCDEPEVHSRCAVILYDIAQCENKD-----V 818
Cdd:PLN03200    60 MPLLVSLLRSGTLGAKVNAAAVLGVLCKEEDLRVKVLLGGCIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDhvgskI 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  819 IAKYNGIPSLINLLN--LNIENVLVN-VMNCIRVLCIGNENNQRAVREHKGLPYLIRFLSSD--------SGLFNLFLNS 887
Cdd:PLN03200   140 FSTEGVVPSLWDQLQpgNKQDKVVEGlLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGnsdaqanaASLLARLMMA 219

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462570407  888 FEDVLKAVSSAaiaevgrdnkeiqdaiameGAIPPLVALF-KGKQISVQMKGAMAVESLASHN 949
Cdd:PLN03200   220 FESSISKVLDA-------------------GAVKQLLKLLgQGNEVSVRAEAAGALEALSSQS 263
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 705-958 4.07e-06

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 51.64  E-value: 4.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  705 LVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQ---CKTVGLLsnISTHKSAVhalve 781
Cdd:PLN03200   493 LVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVESAGAVPALLWLLKNGGPKGQeiaAKTLTKL--VRTADAAT----- 565

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  782 aggIPSLINLLVCDEPEvhSRCAVIlyDIAQC-----ENKDVI----AKYNGIPSLINLLNLNIE-------NVLVNVMN 845
Cdd:PLN03200   566 ---ISQLTALLLGDLPE--SKVHVL--DVLGHvlsvaSLEDLVregsAANDALRTLIQLLSSSKEetqekaaSVLADIFS 638

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  846 CIRVLCigneNNQRAVrehKGLPYLIRFLSSDSglfnlflnsfeDVLKAVSSAAIAEVGRDNKEIQD-AIAMEGAIPPLV 924
Cdd:PLN03200   639 SRQDLC----ESLATD---EIINPCIKLLTNNT-----------EAVATQSARALAALSRSIKENRKvSYAAEDAIKPLI 700

                          250       260       270
                   ....*....|....*....|....*....|....
gi 2462570407  925 ALFKGKQISVQMKGAMAVESLASHNALIQKAFLE 958
Cdd:PLN03200   701 KLAKSSSIEVAEQAVCALANLLSDPEVAAEALAE 734
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 710-945 6.46e-06

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 50.87  E-value: 6.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  710 QCESYKRRMMAVMSLEViclaNDQYWrCILDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKSAVHALVE-AGGIPSL 788
Cdd:PLN03200   461 QQQEYAVALLAILTDEV----DESKW-AITAAGGIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVEsAGAVPAL 535

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  789 INLLVCDEPEVHSRCAVILYDIAQCENKDVIAKyngipsLINLLNLNIENVLVNVMNCIR-VLCIGNENN--QRAVREHK 865
Cdd:PLN03200   536 LWLLKNGGPKGQEIAAKTLTKLVRTADAATISQ------LTALLLGDLPESKVHVLDVLGhVLSVASLEDlvREGSAAND 609

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  866 GLPYLIRFLSSdsglfnlflnSFEDVlKAVSSAAIAEVGRDNKEIQDAIAMEGAIPPLVALFKGKQISVQMKGAMAVESL 945
Cdd:PLN03200   610 ALRTLIQLLSS----------SKEET-QEKAASVLADIFSSRQDLCESLATDEIINPCIKLLTNNTEAVATQSARALAAL 678
Ank_4 pfam13637
Ankyrin repeats (many copies);
641-692 1.42e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.42  E-value: 1.42e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462570407  641 TPLLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYII 692
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 731-771 1.87e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 42.83  E-value: 1.87e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462570407  731 NDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSNIST 771
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
686-848 2.37e-05

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 48.73  E-value: 2.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  686 EVLKYIIKLNIPelpvwKTLVEMLQCESYKRRMMAVMSLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGL 765
Cdd:COG5064    276 EKIQAVLDVGIP-----GRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWT 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  766 LSNIST-HKSAVHALVEAGGIPSLINLLVCDEPEVHSR-CAVILYDIAQCENKDVIAKY---NG-IPSLINLLNLNIENV 839
Cdd:COG5064    351 ISNITAgNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEaCWAISNATSGGLNRPDIIRYlvsQGfIKPLCDLLDVVDNKI 430


                   ....*....
gi 2462570407  840 LVNVMNCIR 848
Cdd:COG5064    431 IEVALDAIE 439
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 738-770 1.05e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 40.88  E-value: 1.05e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2462570407   738 ILDAGTIPALINLLKSSKIKLQCKTVGLLSNIS 770
Cdd:smart00185    8 VVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 723-830 1.27e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 46.63  E-value: 1.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  723 SLEVICLANDQYWRCILDAGTIPALINLLKSSKIKLQCKTVGLLSN-ISTHKSAVHALVEAGGIPSLINLLVC-DEPEVH 800
Cdd:PLN03200   170 ALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARlMMAFESSISKVLDAGAVKQLLKLLGQgNEVSVR 249

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462570407  801 SRCAVILYDI-AQC-ENKDVIAKYNGIPSLIN 830
Cdd:PLN03200   250 AEAAGALEALsSQSkEAKQAIADAGGIPALIN 281
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
571-693 1.42e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 45.33  E-value: 1.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  571 PTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIALCRKDpslLEAEATAENQCTPLLLAATSG 650
Cdd:COG0666     22 ALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAG---ADINAKDDGGNTLLHAAARNG 98

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2462570407  651 ALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 693
Cdd:COG0666     99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE 141
Ank_2 pfam12796
Ankyrin repeats (3 copies);
643-693 2.23e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.25  E-value: 2.23e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462570407  643 LLLAATSGALDTIQYLFSIGANWRKTDIKGNNIIHLSVLTFHTEVLKYIIK 693
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE 51
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 537-664 2.66e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.98  E-value: 2.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  537 FHHAALHNRVSIICQLCNANFKVNQrrfVTFSQGPTPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNV 616
Cdd:PHA02875    72 LHDAVEEGDVKAVEELLDLGKFADD---VFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462570407  617 CIIialcrkdPSLLEAEATAENQ----CTPLLLAATSGALDTIQYLFSIGAN 664
Cdd:PHA02875   149 KGI-------ELLIDHKACLDIEdccgCTPLIIAMAKGDIAICKMLLDSGAN 193
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 521-636 2.80e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.95  E-value: 2.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  521 TSSSTINVSDEAGYTIFHHAALHNRvSIICQLCNaNFKVNqrrfVTFSQGPTPLHLAAQ-ACSLETTVCLLCSKADYTLS 599
Cdd:PHA02874   211 DHGNHIMNKCKNGFTPLHNAIIHNR-SAIELLIN-NASIN----DQDIDGSTPLHHAINpPCDIDIIDILLYHKADISIK 284

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 2462570407  600 EKRGWMPIHFAAFYDNvciiialcrKDPSLLEAEATA 636
Cdd:PHA02874   285 DNKGENPIDTAFKYIN---------KDPVIKDIIANA 312
Ank_4 pfam13637
Ankyrin repeats (many copies);
572-622 2.96e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 2.96e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462570407  572 TPLHLAAQACSLETTVCLLCSKADYTLSEKRGWMPIHFAAFYDNVCIIIAL 622
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_2 pfam12796
Ankyrin repeats (3 copies);
526-598 3.81e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.87  E-value: 3.81e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462570407  526 INVSDEAGYTIFHHAALHNRVSIICQLCNanfKVNQRRfvtFSQGPTPLHLAAQACSLETTVCLLCSKADYTL 598
Cdd:pfam12796   23 ANLQDKNGRTALHLAAKNGHLEIVKLLLE---HADVNL---KDNGRTALHYAARSGHLEIVKLLLEKGADINV 89
Ank_5 pfam13857
Ankyrin repeats (many copies);
526-577 5.86e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 5.86e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462570407  526 INVSDEAGYTIFHHAALHNRVSIICQLCNANFKVNQRRFvtfsQGPTPLHLA 577
Cdd:pfam13857    9 LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDE----EGLTALDLA 56
HEAT COG1413
HEAT repeat [General function prediction only];
701-811 6.81e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 38.46  E-value: 6.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462570407  701 VWKTLVEMLQCESYKRRMMAVMSLEVIClandqywrcilDAGTIPALINLLKSSKIKLQCKTVGLLSNISTHKS------ 774
Cdd:COG1413     17 AVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAvpalia 85

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462570407  775 ------------AVHALVEAGG---IPSLINLLVCDEPEVHSRCAVILYDIA 811
Cdd:COG1413     86 alkdedpevrraAAEALGRLGDpaaVPALLEALKDPDWEVRRAAARALGRLG 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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