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Conserved domains on  [gi|2462573562|ref|XP_054198178|]
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NGFI-A-binding protein 1 isoform X3 [Homo sapiens]

Protein Classification

NCD1 and NCD2 domain-containing protein( domain architecture ID 10706360)

protein containing domains NCD1, NCD2, and Nab1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NCD2 pfam04905
NAB conserved region 2 (NCD2); Nab1 and Nab2 are co-repressors that specifically interact with ...
 190-318 1.58e-73

NAB conserved region 2 (NCD2); Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This family consists of NAB conserved region 2, near the C-terminus of the protein. It is necessary for transcriptional repression by the Nab proteins. It is also required for transcription activation by Nab proteins at Nab-activated promoters.


:

Pssm-ID: 461474  Cd Length: 125  Bit Score: 226.86  E-value: 1.58e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573562 190 ALDAAAALSVAECVERMAPTLPKSDLnevkELLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGRFDSKRKDGKHL 269
Cdd:pfam04905   1 VLSEAQVQRVAECAERLVRTLPRLDP----KLLKNKKKLAKDVEHIMEMSEDDPRRMEEIRKYSAIYGRFDSKRRPEKPL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2462573562 270 TLHELTVNEAAAQLCVKDNALLTRRDELFALARQISREVTYKYTYRTTK 318
Cdd:pfam04905  77 TLHEVTVNEAAAQLCMRDPALLTRRDELFPLARQVVRDAGYHYSKSHSR 125
Nab1 super family cl04833
Conserved region in Nab1; Nab1 and Nab2 are co-repressors that specifically interact with and ...
 322-456 6.30e-57

Conserved region in Nab1; Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This C-terminal region is found only in the Nab1 subfamily.


The actual alignment was detected with superfamily member pfam04902:

Pssm-ID: 461472  Cd Length: 180  Bit Score: 186.23  E-value: 6.30e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573562 322 GERDELSPKRIKVE-----------------------------------------QPEKVMAKQMEFLCNQAGYERLQHA 360
Cdd:pfam04902   1 GDRDEPSPKRIKTEdgfpdfqealqalhmrqetlreqlalakskgeetvgrnlqvQLERLLAKQMEILCDAAVQERLQAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573562 361 ERRLSAGLYRQSSEEHSPNGLTSDNSDGQGERPLNLRMPNLQNRQP---HHFV--VDGELSRLYP-SEAKSHSSESLGil 434
Cdd:pfam04902  81 EWRLPTGAYKQLSEEQSTNGLAADSSDGQGERPLNLRVSNQQMRQLegeLPLGkqLANELKRHHPhEEAKSQATENGG-- 158

                         170       180
                  ....*....|....*....|...
gi 2462573562 435 kDYPHSAFT-LEKKVIKTEPEDS 456
Cdd:pfam04902 159 -DFPQSAFSnLEKKVIKSEPEDS 180
NCD1 pfam04904
NAB conserved region 1 (NCD1); Nab1 and Nab2 are co-repressors that specifically interact with ...
 5-83 1.66e-49

NAB conserved region 1 (NCD1); Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This region consists of the N-terminal NAB conserved region 1, which interacts with the EGR1 inhibitory domain (R1). It may also mediate multimerization.


:

Pssm-ID: 461473  Cd Length: 79  Bit Score: 163.40  E-value: 1.66e-49
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462573562   5 LPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALRDWVTNPGLFN 83
Cdd:pfam04904   1 TPSTLSELQLYRVLQRANLLQYYDTFISQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALQEWVTNPSAFQ 79
 
Name Accession Description Interval E-value
NCD2 pfam04905
NAB conserved region 2 (NCD2); Nab1 and Nab2 are co-repressors that specifically interact with ...
 190-318 1.58e-73

NAB conserved region 2 (NCD2); Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This family consists of NAB conserved region 2, near the C-terminus of the protein. It is necessary for transcriptional repression by the Nab proteins. It is also required for transcription activation by Nab proteins at Nab-activated promoters.


Pssm-ID: 461474  Cd Length: 125  Bit Score: 226.86  E-value: 1.58e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573562 190 ALDAAAALSVAECVERMAPTLPKSDLnevkELLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGRFDSKRKDGKHL 269
Cdd:pfam04905   1 VLSEAQVQRVAECAERLVRTLPRLDP----KLLKNKKKLAKDVEHIMEMSEDDPRRMEEIRKYSAIYGRFDSKRRPEKPL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2462573562 270 TLHELTVNEAAAQLCVKDNALLTRRDELFALARQISREVTYKYTYRTTK 318
Cdd:pfam04905  77 TLHEVTVNEAAAQLCMRDPALLTRRDELFPLARQVVRDAGYHYSKSHSR 125
Nab1 pfam04902
Conserved region in Nab1; Nab1 and Nab2 are co-repressors that specifically interact with and ...
 322-456 6.30e-57

Conserved region in Nab1; Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This C-terminal region is found only in the Nab1 subfamily.


Pssm-ID: 461472  Cd Length: 180  Bit Score: 186.23  E-value: 6.30e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573562 322 GERDELSPKRIKVE-----------------------------------------QPEKVMAKQMEFLCNQAGYERLQHA 360
Cdd:pfam04902   1 GDRDEPSPKRIKTEdgfpdfqealqalhmrqetlreqlalakskgeetvgrnlqvQLERLLAKQMEILCDAAVQERLQAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573562 361 ERRLSAGLYRQSSEEHSPNGLTSDNSDGQGERPLNLRMPNLQNRQP---HHFV--VDGELSRLYP-SEAKSHSSESLGil 434
Cdd:pfam04902  81 EWRLPTGAYKQLSEEQSTNGLAADSSDGQGERPLNLRVSNQQMRQLegeLPLGkqLANELKRHHPhEEAKSQATENGG-- 158

                         170       180
                  ....*....|....*....|...
gi 2462573562 435 kDYPHSAFT-LEKKVIKTEPEDS 456
Cdd:pfam04902 159 -DFPQSAFSnLEKKVIKSEPEDS 180
NCD1 pfam04904
NAB conserved region 1 (NCD1); Nab1 and Nab2 are co-repressors that specifically interact with ...
 5-83 1.66e-49

NAB conserved region 1 (NCD1); Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This region consists of the N-terminal NAB conserved region 1, which interacts with the EGR1 inhibitory domain (R1). It may also mediate multimerization.


Pssm-ID: 461473  Cd Length: 79  Bit Score: 163.40  E-value: 1.66e-49
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462573562   5 LPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALRDWVTNPGLFN 83
Cdd:pfam04904   1 TPSTLSELQLYRVLQRANLLQYYDTFISQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALQEWVTNPSAFQ 79
 
Name Accession Description Interval E-value
NCD2 pfam04905
NAB conserved region 2 (NCD2); Nab1 and Nab2 are co-repressors that specifically interact with ...
 190-318 1.58e-73

NAB conserved region 2 (NCD2); Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This family consists of NAB conserved region 2, near the C-terminus of the protein. It is necessary for transcriptional repression by the Nab proteins. It is also required for transcription activation by Nab proteins at Nab-activated promoters.


Pssm-ID: 461474  Cd Length: 125  Bit Score: 226.86  E-value: 1.58e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573562 190 ALDAAAALSVAECVERMAPTLPKSDLnevkELLKTNKKLAKMIGHIFEMNDDDPHKEEEIRKYSAIYGRFDSKRKDGKHL 269
Cdd:pfam04905   1 VLSEAQVQRVAECAERLVRTLPRLDP----KLLKNKKKLAKDVEHIMEMSEDDPRRMEEIRKYSAIYGRFDSKRRPEKPL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 2462573562 270 TLHELTVNEAAAQLCVKDNALLTRRDELFALARQISREVTYKYTYRTTK 318
Cdd:pfam04905  77 TLHEVTVNEAAAQLCMRDPALLTRRDELFPLARQVVRDAGYHYSKSHSR 125
Nab1 pfam04902
Conserved region in Nab1; Nab1 and Nab2 are co-repressors that specifically interact with and ...
 322-456 6.30e-57

Conserved region in Nab1; Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This C-terminal region is found only in the Nab1 subfamily.


Pssm-ID: 461472  Cd Length: 180  Bit Score: 186.23  E-value: 6.30e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573562 322 GERDELSPKRIKVE-----------------------------------------QPEKVMAKQMEFLCNQAGYERLQHA 360
Cdd:pfam04902   1 GDRDEPSPKRIKTEdgfpdfqealqalhmrqetlreqlalakskgeetvgrnlqvQLERLLAKQMEILCDAAVQERLQAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462573562 361 ERRLSAGLYRQSSEEHSPNGLTSDNSDGQGERPLNLRMPNLQNRQP---HHFV--VDGELSRLYP-SEAKSHSSESLGil 434
Cdd:pfam04902  81 EWRLPTGAYKQLSEEQSTNGLAADSSDGQGERPLNLRVSNQQMRQLegeLPLGkqLANELKRHHPhEEAKSQATENGG-- 158

                         170       180
                  ....*....|....*....|...
gi 2462573562 435 kDYPHSAFT-LEKKVIKTEPEDS 456
Cdd:pfam04902 159 -DFPQSAFSnLEKKVIKSEPEDS 180
NCD1 pfam04904
NAB conserved region 1 (NCD1); Nab1 and Nab2 are co-repressors that specifically interact with ...
 5-83 1.66e-49

NAB conserved region 1 (NCD1); Nab1 and Nab2 are co-repressors that specifically interact with and repress transcription mediated by the three members of the NGFI-A (Egr-1, Krox24, zif/268) family of transcription factors. This region consists of the N-terminal NAB conserved region 1, which interacts with the EGR1 inhibitory domain (R1). It may also mediate multimerization.


Pssm-ID: 461473  Cd Length: 79  Bit Score: 163.40  E-value: 1.66e-49
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462573562   5 LPRTLGELQLYRILQKANLLSYFDAFIQQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALRDWVTNPGLFN 83
Cdd:pfam04904   1 TPSTLSELQLYRVLQRANLLQYYDTFISQGGDDVQQLCEAGEEEFLEIMALVGMASKPLHVRRLQKALQEWVTNPSAFQ 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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