NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462575399|ref|XP_054199049|]
View 

E3 ubiquitin-protein ligase pellino homolog 1 isoform X1 [Homo sapiens]

Protein Classification

E3 ubiquitin-protein ligase pellino family protein( domain architecture ID 10520238)

E3 ubiquitin-protein ligase pellino family protein which catalyzes the covalent attachment of ubiquitin moieties onto substrate proteins, and is involved in the TLR and IL-1 signaling pathways; similar to human E3 ubiquitin-protein ligase pellino homolog 1 (pellino-1)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Pellino pfam04710
Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase ...
 10-418 0e+00

Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase.


:

Pssm-ID: 461403  Cd Length: 409  Bit Score: 885.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575399  10 PSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVV 89
Cdd:pfam04710   1 PSKEPIKYGELVILGYNGSLPNGDKGRRRSKFVLYKRPKANGVKPSKHHIVKTPQASKAILDKGQHSISYTLSRNQAVVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575399  90 EYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEK 169
Cdd:pfam04710  81 EYTHDEDTDMFQIGRSSESPIDFVVMDTVPGDKTGEETQVAQSTISRFACRILVDRNPPYTARIYAAGFDSSKNIFLGEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575399 170 AAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGA 249
Cdd:pfam04710 161 ATKWKTPDGEMDGLTTNGVLIMHPRGGFCEDSKPGVWREVSVCGGVYSLRETRSAQQKGKLVENESNILQDGTLIDLCGA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575399 250 TLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKR-KDVVDEKQPWVYLNCGHVHGYHNWGNKEERDG 328
Cdd:pfam04710 241 TLLWRSAEGLLRSPTLKHLEALRDEINAGRPQCPVGLNTLVFPRKSRgRSSEEEKQPYVYLNCGHVHGYHDWGQKEESGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575399 329 kDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGY 408
Cdd:pfam04710 321 -RRECPMCREVGPYVPLWMGCEPAFYVDSGPPTHAFNPCGHVCSEKTVRYWSQIPLPHGTHAFHAACPFCATPLTGEPGY 399

                         410
                  ....*....|
gi 2462575399 409 IRLIFQGPLD 418
Cdd:pfam04710 400 VKLIFQDNVD 409
 
Name Accession Description Interval E-value
Pellino pfam04710
Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase ...
 10-418 0e+00

Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase.


Pssm-ID: 461403  Cd Length: 409  Bit Score: 885.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575399  10 PSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVV 89
Cdd:pfam04710   1 PSKEPIKYGELVILGYNGSLPNGDKGRRRSKFVLYKRPKANGVKPSKHHIVKTPQASKAILDKGQHSISYTLSRNQAVVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575399  90 EYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEK 169
Cdd:pfam04710  81 EYTHDEDTDMFQIGRSSESPIDFVVMDTVPGDKTGEETQVAQSTISRFACRILVDRNPPYTARIYAAGFDSSKNIFLGEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575399 170 AAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGA 249
Cdd:pfam04710 161 ATKWKTPDGEMDGLTTNGVLIMHPRGGFCEDSKPGVWREVSVCGGVYSLRETRSAQQKGKLVENESNILQDGTLIDLCGA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575399 250 TLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKR-KDVVDEKQPWVYLNCGHVHGYHNWGNKEERDG 328
Cdd:pfam04710 241 TLLWRSAEGLLRSPTLKHLEALRDEINAGRPQCPVGLNTLVFPRKSRgRSSEEEKQPYVYLNCGHVHGYHDWGQKEESGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575399 329 kDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGY 408
Cdd:pfam04710 321 -RRECPMCREVGPYVPLWMGCEPAFYVDSGPPTHAFNPCGHVCSEKTVRYWSQIPLPHGTHAFHAACPFCATPLTGEPGY 399

                         410
                  ....*....|
gi 2462575399 409 IRLIFQGPLD 418
Cdd:pfam04710 400 VKLIFQDNVD 409
 
Name Accession Description Interval E-value
Pellino pfam04710
Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase ...
 10-418 0e+00

Pellino; Pellino is involved in Toll-like signalling pathways, and associates with the kinase domain of the Pelle Ser/Thr kinase.


Pssm-ID: 461403  Cd Length: 409  Bit Score: 885.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575399  10 PSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVV 89
Cdd:pfam04710   1 PSKEPIKYGELVILGYNGSLPNGDKGRRRSKFVLYKRPKANGVKPSKHHIVKTPQASKAILDKGQHSISYTLSRNQAVVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575399  90 EYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERNPPFTARIYAAGFDSSKNIFLGEK 169
Cdd:pfam04710  81 EYTHDEDTDMFQIGRSSESPIDFVVMDTVPGDKTGEETQVAQSTISRFACRILVDRNPPYTARIYAAGFDSSKNIFLGEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575399 170 AAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGA 249
Cdd:pfam04710 161 ATKWKTPDGEMDGLTTNGVLIMHPRGGFCEDSKPGVWREVSVCGGVYSLRETRSAQQKGKLVENESNILQDGTLIDLCGA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575399 250 TLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKR-KDVVDEKQPWVYLNCGHVHGYHNWGNKEERDG 328
Cdd:pfam04710 241 TLLWRSAEGLLRSPTLKHLEALRDEINAGRPQCPVGLNTLVFPRKSRgRSSEEEKQPYVYLNCGHVHGYHDWGQKEESGA 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462575399 329 kDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGY 408
Cdd:pfam04710 321 -RRECPMCREVGPYVPLWMGCEPAFYVDSGPPTHAFNPCGHVCSEKTVRYWSQIPLPHGTHAFHAACPFCATPLTGEPGY 399

                         410
                  ....*....|
gi 2462575399 409 IRLIFQGPLD 418
Cdd:pfam04710 400 VKLIFQDNVD 409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH