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Conserved domains on  [gi|2462576066|ref|XP_054199366|]
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anaphase-promoting complex subunit 1 isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Apc1_MidN super family cl48671
Anaphase-promoting complex subunit 1 middle domain; Apc1 is the largest of the subunits of the ...
 517-887 0e+00

Anaphase-promoting complex subunit 1 middle domain; Apc1 is the largest of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Apc1 consists of a N-terminal WD40 beta-propeller domain, followed by the middle domain (Mid-N), a PC domain and the C-terminal domain (MidC). This entry represents the middle domain of Apc1, MidN (also referred to as the first helical domain), that coaleses with the C-terminal domain to form Apc1Mid that connects Apc1WD40 with Apc1PC. Apc1Mid consists of an alpha-solenoid capped by a beta-sandwich.


The actual alignment was detected with superfamily member pfam20518:

Pssm-ID: 466667  Cd Length: 371  Bit Score: 803.55  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  517 SELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLFVTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPK 596
Cdd:pfam20518    1 SELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLFVTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  597 KARPSETGSDDDWEYLLNSDYHQNVESHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELK 676
Cdd:pfam20518   81 KARPSETGSDDDWEYLLNSDYHQNVESHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  677 LNTLMGEGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSEPPSIYQWVSSCLKG 756
Cdd:pfam20518  161 LNTLMGEGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSEPPSIYQWVSSCLKG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  757 EGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRITIAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWM 836
Cdd:pfam20518  241 EGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRITIAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWM 320

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462576066  837 TNVGFTLRDLETLPFGIALPIRDAIYHCREQPASDWPEAVCLLIGRQDLSK 887
Cdd:pfam20518  321 TNVGFTLRDLETLPFGIALPIRDAIYHCREQPASDWPEAVCLLIGRQDLSK 371
APC1_C pfam18122
Anaphase-promoting complex sub unit 1 C-terminal domain; This is the C-terminal domain of ...
 1645-1801 6.75e-49

Anaphase-promoting complex sub unit 1 C-terminal domain; This is the C-terminal domain of chain A, also known as sub-unit 1, found in anaphase-promoting complex (APC/C) present in Homo sapiens. APC/C is an ubiquitin ligase that controls chromosome segregation and mitotic exit.


:

Pssm-ID: 465659  Cd Length: 159  Bit Score: 171.39  E-value: 6.75e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066 1645 SAFTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQETPEMLPAYIAMDQAIRRLGRREMSETSELWQIKLVL 1724
Cdd:pfam18122    1 KSFSSDPSLLAFADYFCTPSSNTEAEVDFAAFCSSVLLECLTQDKPELLPTYLALYSAIQNLEASSSPASLALWQLRLIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066 1725 EFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWLQVGGDMcVHAYLSGQ---PLEESQLSMLACFLVYHSVP 1801
Cdd:pfam18122   81 EFYGSLYFLRFSGRGESREPLIRSSFLLSLKSRVDAKLDEWLKEGSNL-LRRYLRGGgdgSSDSSLLRMLAAYLVFYDIP 159
Apc1_N super family cl44935
Anaphase-promoting complex subunit 1 N-terminal; The anaphase-promoting complex subunit 1 ...
 1-38 5.70e-20

Anaphase-promoting complex subunit 1 N-terminal; The anaphase-promoting complex subunit 1 (Apc1) is the largest scaffolding subunit that constitutes anaphase-promoting complex/cyclosome (APC/C), the crucial RING E3 ubiquitin ligase that controls cell cycle processes like sister chromatid segregation, cytokinesis and the initiation of chromosome replication. This domain represents the Apc1 N-terminal region that is rich in beta-strands and regulatory phosphorylation sites. It contains WD40 repeats and is essential for APC/C catalytic activity as it mediates the coactivator-induced conformational change of the APC/C which promotes UbcH10 binding.


The actual alignment was detected with superfamily member pfam19521:

Pssm-ID: 437353  Cd Length: 136  Bit Score: 87.71  E-value: 5.70e-20
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462576066    1 MVIWSKGSKSQALAVYKAFTVDSPVQQALWCDFIISQD 38
Cdd:pfam19521   99 MVIWSKGSKTQASAVYKAFTVDSPVQQALWCDFTVPQE 136
ANAPC1 super family cl15124
Anaphase-promoting complex subunit 1 WD40 beta-propeller domain; Apc1 is the largest of the ...
 53-261 3.60e-13

Anaphase-promoting complex subunit 1 WD40 beta-propeller domain; Apc1 is the largest of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Infection of human fibroblasts with human cytomegalovirus (HCMV) leads to cell cycle dysregulation, which is associated with the inactivation of the anaphase-promoting complex. Apc1 consists of a N-terminal WD40 beta-propeller domain, a middle domain (Mid-N), a PC domain and a C-terminal domain (Mid-C) that coalesces with Mid-N to form Apc1Mid which connects Apc1-WD40 with Apc1-PC and comprises an alpha-solenoid capped by a beta-sandwich. The N-terminal domain is essential for APC/C catalytic activity as it mediates the coactivator-induced conformational change of the APC/C which promotes UbcH10 binding.


The actual alignment was detected with superfamily member pfam12859:

Pssm-ID: 463732  Cd Length: 295  Bit Score: 72.08  E-value: 3.60e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066   53 ICILQSSCINMHSIEGKDYIASLPFQVANVWPTKYGLLFERSASSHE--------VPP------------------GSPR 106
Cdd:pfam12859    2 LVVFLKTQAHIYFLSGESHVVPLPFEVESAFPAPRGLLLQRKLEEDErsslkfpaAPPnsfvssqsspldrsrkslGNPR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  107 EP----------------------LPTMFSMLHPLDEITPLVCKSGSLFGSSRVQ------YVVDHAMKIVF-------- 150
Cdd:pfam12859   82 RSsltlsstlgdmwdpppedsdsdLPRLFSLTDPLSELGLVVTSSQSSRSSSPRRdsspqpEFLDPAEEILYvsdldest 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  151 -LNTDPSIVM-TYDAVQNVHSVWTLRRVKSEEENVVLKF-------SEQGGTPQNVATSSSLTAHLRSlSKGDSPVTSPF 221
Cdd:pfam12859  162 iWTSDPLPLVvTLNRETSQYTIWRAEYLESESESSSSKKrkrsrrrSSFMGMATGATTPVARPSNLRE-SFGPLSGKRPR 240

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 2462576066  222 QNYSSIHSQSRSTSSPSLHSRSPSISNMAALSRAHSPALG 261
Cdd:pfam12859  241 SSESHSDEKDEEDLASQLDPDFDDIGVPRRSSRRVSSLLA 280
PC_rep pfam01851
Proteasome/cyclosome repeat;
1373-1407 4.08e-03

Proteasome/cyclosome repeat;


:

Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 36.63  E-value: 4.08e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462576066 1373 GACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLSA 1407
Cdd:pfam01851    1 GAALALGLIHAGSGNEEALDLLLPYLSDTSAESRA 35
 
Name Accession Description Interval E-value
Apc1_MidN pfam20518
Anaphase-promoting complex subunit 1 middle domain; Apc1 is the largest of the subunits of the ...
 517-887 0e+00

Anaphase-promoting complex subunit 1 middle domain; Apc1 is the largest of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Apc1 consists of a N-terminal WD40 beta-propeller domain, followed by the middle domain (Mid-N), a PC domain and the C-terminal domain (MidC). This entry represents the middle domain of Apc1, MidN (also referred to as the first helical domain), that coaleses with the C-terminal domain to form Apc1Mid that connects Apc1WD40 with Apc1PC. Apc1Mid consists of an alpha-solenoid capped by a beta-sandwich.


Pssm-ID: 466667  Cd Length: 371  Bit Score: 803.55  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  517 SELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLFVTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPK 596
Cdd:pfam20518    1 SELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLFVTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  597 KARPSETGSDDDWEYLLNSDYHQNVESHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELK 676
Cdd:pfam20518   81 KARPSETGSDDDWEYLLNSDYHQNVESHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  677 LNTLMGEGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSEPPSIYQWVSSCLKG 756
Cdd:pfam20518  161 LNTLMGEGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSEPPSIYQWVSSCLKG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  757 EGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRITIAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWM 836
Cdd:pfam20518  241 EGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRITIAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWM 320

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462576066  837 TNVGFTLRDLETLPFGIALPIRDAIYHCREQPASDWPEAVCLLIGRQDLSK 887
Cdd:pfam20518  321 TNVGFTLRDLETLPFGIALPIRDAIYHCREQPASDWPEAVCLLIGRQDLSK 371
APC1_C pfam18122
Anaphase-promoting complex sub unit 1 C-terminal domain; This is the C-terminal domain of ...
 1645-1801 6.75e-49

Anaphase-promoting complex sub unit 1 C-terminal domain; This is the C-terminal domain of chain A, also known as sub-unit 1, found in anaphase-promoting complex (APC/C) present in Homo sapiens. APC/C is an ubiquitin ligase that controls chromosome segregation and mitotic exit.


Pssm-ID: 465659  Cd Length: 159  Bit Score: 171.39  E-value: 6.75e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066 1645 SAFTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQETPEMLPAYIAMDQAIRRLGRREMSETSELWQIKLVL 1724
Cdd:pfam18122    1 KSFSSDPSLLAFADYFCTPSSNTEAEVDFAAFCSSVLLECLTQDKPELLPTYLALYSAIQNLEASSSPASLALWQLRLIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066 1725 EFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWLQVGGDMcVHAYLSGQ---PLEESQLSMLACFLVYHSVP 1801
Cdd:pfam18122   81 EFYGSLYFLRFSGRGESREPLIRSSFLLSLKSRVDAKLDEWLKEGSNL-LRRYLRGGgdgSSDSSLLRMLAAYLVFYDIP 159
Apc1_N pfam19521
Anaphase-promoting complex subunit 1 N-terminal; The anaphase-promoting complex subunit 1 ...
 1-38 5.70e-20

Anaphase-promoting complex subunit 1 N-terminal; The anaphase-promoting complex subunit 1 (Apc1) is the largest scaffolding subunit that constitutes anaphase-promoting complex/cyclosome (APC/C), the crucial RING E3 ubiquitin ligase that controls cell cycle processes like sister chromatid segregation, cytokinesis and the initiation of chromosome replication. This domain represents the Apc1 N-terminal region that is rich in beta-strands and regulatory phosphorylation sites. It contains WD40 repeats and is essential for APC/C catalytic activity as it mediates the coactivator-induced conformational change of the APC/C which promotes UbcH10 binding.


Pssm-ID: 437353  Cd Length: 136  Bit Score: 87.71  E-value: 5.70e-20
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462576066    1 MVIWSKGSKSQALAVYKAFTVDSPVQQALWCDFIISQD 38
Cdd:pfam19521   99 MVIWSKGSKTQASAVYKAFTVDSPVQQALWCDFTVPQE 136
ANAPC1 pfam12859
Anaphase-promoting complex subunit 1 WD40 beta-propeller domain; Apc1 is the largest of the ...
 53-261 3.60e-13

Anaphase-promoting complex subunit 1 WD40 beta-propeller domain; Apc1 is the largest of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Infection of human fibroblasts with human cytomegalovirus (HCMV) leads to cell cycle dysregulation, which is associated with the inactivation of the anaphase-promoting complex. Apc1 consists of a N-terminal WD40 beta-propeller domain, a middle domain (Mid-N), a PC domain and a C-terminal domain (Mid-C) that coalesces with Mid-N to form Apc1Mid which connects Apc1-WD40 with Apc1-PC and comprises an alpha-solenoid capped by a beta-sandwich. The N-terminal domain is essential for APC/C catalytic activity as it mediates the coactivator-induced conformational change of the APC/C which promotes UbcH10 binding.


Pssm-ID: 463732  Cd Length: 295  Bit Score: 72.08  E-value: 3.60e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066   53 ICILQSSCINMHSIEGKDYIASLPFQVANVWPTKYGLLFERSASSHE--------VPP------------------GSPR 106
Cdd:pfam12859    2 LVVFLKTQAHIYFLSGESHVVPLPFEVESAFPAPRGLLLQRKLEEDErsslkfpaAPPnsfvssqsspldrsrkslGNPR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  107 EP----------------------LPTMFSMLHPLDEITPLVCKSGSLFGSSRVQ------YVVDHAMKIVF-------- 150
Cdd:pfam12859   82 RSsltlsstlgdmwdpppedsdsdLPRLFSLTDPLSELGLVVTSSQSSRSSSPRRdsspqpEFLDPAEEILYvsdldest 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  151 -LNTDPSIVM-TYDAVQNVHSVWTLRRVKSEEENVVLKF-------SEQGGTPQNVATSSSLTAHLRSlSKGDSPVTSPF 221
Cdd:pfam12859  162 iWTSDPLPLVvTLNRETSQYTIWRAEYLESESESSSSKKrkrsrrrSSFMGMATGATTPVARPSNLRE-SFGPLSGKRPR 240

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 2462576066  222 QNYSSIHSQSRSTSSPSLHSRSPSISNMAALSRAHSPALG 261
Cdd:pfam12859  241 SSESHSDEKDEEDLASQLDPDFDDIGVPRRSSRRVSSLLA 280
PC_rep pfam01851
Proteasome/cyclosome repeat;
1373-1407 4.08e-03

Proteasome/cyclosome repeat;


Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 36.63  E-value: 4.08e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462576066 1373 GACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLSA 1407
Cdd:pfam01851    1 GAALALGLIHAGSGNEEALDLLLPYLSDTSAESRA 35
 
Name Accession Description Interval E-value
Apc1_MidN pfam20518
Anaphase-promoting complex subunit 1 middle domain; Apc1 is the largest of the subunits of the ...
 517-887 0e+00

Anaphase-promoting complex subunit 1 middle domain; Apc1 is the largest of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Apc1 consists of a N-terminal WD40 beta-propeller domain, followed by the middle domain (Mid-N), a PC domain and the C-terminal domain (MidC). This entry represents the middle domain of Apc1, MidN (also referred to as the first helical domain), that coaleses with the C-terminal domain to form Apc1Mid that connects Apc1WD40 with Apc1PC. Apc1Mid consists of an alpha-solenoid capped by a beta-sandwich.


Pssm-ID: 466667  Cd Length: 371  Bit Score: 803.55  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  517 SELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLFVTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPK 596
Cdd:pfam20518    1 SELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLFVTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPK 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  597 KARPSETGSDDDWEYLLNSDYHQNVESHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELK 676
Cdd:pfam20518   81 KARPSETGSDDDWEYLLNSDYHQNVESHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELK 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  677 LNTLMGEGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSEPPSIYQWVSSCLKG 756
Cdd:pfam20518  161 LNTLMGEGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSEPPSIYQWVSSCLKG 240

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  757 EGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRITIAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWM 836
Cdd:pfam20518  241 EGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRITIAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWM 320

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462576066  837 TNVGFTLRDLETLPFGIALPIRDAIYHCREQPASDWPEAVCLLIGRQDLSK 887
Cdd:pfam20518  321 TNVGFTLRDLETLPFGIALPIRDAIYHCREQPASDWPEAVCLLIGRQDLSK 371
APC1_C pfam18122
Anaphase-promoting complex sub unit 1 C-terminal domain; This is the C-terminal domain of ...
 1645-1801 6.75e-49

Anaphase-promoting complex sub unit 1 C-terminal domain; This is the C-terminal domain of chain A, also known as sub-unit 1, found in anaphase-promoting complex (APC/C) present in Homo sapiens. APC/C is an ubiquitin ligase that controls chromosome segregation and mitotic exit.


Pssm-ID: 465659  Cd Length: 159  Bit Score: 171.39  E-value: 6.75e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066 1645 SAFTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQETPEMLPAYIAMDQAIRRLGRREMSETSELWQIKLVL 1724
Cdd:pfam18122    1 KSFSSDPSLLAFADYFCTPSSNTEAEVDFAAFCSSVLLECLTQDKPELLPTYLALYSAIQNLEASSSPASLALWQLRLIL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066 1725 EFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWLQVGGDMcVHAYLSGQ---PLEESQLSMLACFLVYHSVP 1801
Cdd:pfam18122   81 EFYGSLYFLRFSGRGESREPLIRSSFLLSLKSRVDAKLDEWLKEGSNL-LRRYLRGGgdgSSDSSLLRMLAAYLVFYDIP 159
Apc1_N pfam19521
Anaphase-promoting complex subunit 1 N-terminal; The anaphase-promoting complex subunit 1 ...
 1-38 5.70e-20

Anaphase-promoting complex subunit 1 N-terminal; The anaphase-promoting complex subunit 1 (Apc1) is the largest scaffolding subunit that constitutes anaphase-promoting complex/cyclosome (APC/C), the crucial RING E3 ubiquitin ligase that controls cell cycle processes like sister chromatid segregation, cytokinesis and the initiation of chromosome replication. This domain represents the Apc1 N-terminal region that is rich in beta-strands and regulatory phosphorylation sites. It contains WD40 repeats and is essential for APC/C catalytic activity as it mediates the coactivator-induced conformational change of the APC/C which promotes UbcH10 binding.


Pssm-ID: 437353  Cd Length: 136  Bit Score: 87.71  E-value: 5.70e-20
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462576066    1 MVIWSKGSKSQALAVYKAFTVDSPVQQALWCDFIISQD 38
Cdd:pfam19521   99 MVIWSKGSKTQASAVYKAFTVDSPVQQALWCDFTVPQE 136
ANAPC1 pfam12859
Anaphase-promoting complex subunit 1 WD40 beta-propeller domain; Apc1 is the largest of the ...
 53-261 3.60e-13

Anaphase-promoting complex subunit 1 WD40 beta-propeller domain; Apc1 is the largest of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. Infection of human fibroblasts with human cytomegalovirus (HCMV) leads to cell cycle dysregulation, which is associated with the inactivation of the anaphase-promoting complex. Apc1 consists of a N-terminal WD40 beta-propeller domain, a middle domain (Mid-N), a PC domain and a C-terminal domain (Mid-C) that coalesces with Mid-N to form Apc1Mid which connects Apc1-WD40 with Apc1-PC and comprises an alpha-solenoid capped by a beta-sandwich. The N-terminal domain is essential for APC/C catalytic activity as it mediates the coactivator-induced conformational change of the APC/C which promotes UbcH10 binding.


Pssm-ID: 463732  Cd Length: 295  Bit Score: 72.08  E-value: 3.60e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066   53 ICILQSSCINMHSIEGKDYIASLPFQVANVWPTKYGLLFERSASSHE--------VPP------------------GSPR 106
Cdd:pfam12859    2 LVVFLKTQAHIYFLSGESHVVPLPFEVESAFPAPRGLLLQRKLEEDErsslkfpaAPPnsfvssqsspldrsrkslGNPR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  107 EP----------------------LPTMFSMLHPLDEITPLVCKSGSLFGSSRVQ------YVVDHAMKIVF-------- 150
Cdd:pfam12859   82 RSsltlsstlgdmwdpppedsdsdLPRLFSLTDPLSELGLVVTSSQSSRSSSPRRdsspqpEFLDPAEEILYvsdldest 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576066  151 -LNTDPSIVM-TYDAVQNVHSVWTLRRVKSEEENVVLKF-------SEQGGTPQNVATSSSLTAHLRSlSKGDSPVTSPF 221
Cdd:pfam12859  162 iWTSDPLPLVvTLNRETSQYTIWRAEYLESESESSSSKKrkrsrrrSSFMGMATGATTPVARPSNLRE-SFGPLSGKRPR 240

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 2462576066  222 QNYSSIHSQSRSTSSPSLHSRSPSISNMAALSRAHSPALG 261
Cdd:pfam12859  241 SSESHSDEKDEEDLASQLDPDFDDIGVPRRSSRRVSSLLA 280
PC_rep pfam01851
Proteasome/cyclosome repeat;
1373-1407 4.08e-03

Proteasome/cyclosome repeat;


Pssm-ID: 460361 [Multi-domain]  Cd Length: 35  Bit Score: 36.63  E-value: 4.08e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462576066 1373 GACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLSA 1407
Cdd:pfam01851    1 GAALALGLIHAGSGNEEALDLLLPYLSDTSAESRA 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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