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Conserved domains on  [gi|2462576410|ref|XP_054199532|]
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protein ITPRID2 isoform X6 [Homo sapiens]

Protein Classification

KRAP_IP3R_bind and SSFA2_C domain-containing protein( domain architecture ID 10631615)

KRAP_IP3R_bind and SSFA2_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAP_IP3R_bind pfam14722
Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the ...
 148-300 6.10e-67

Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localized as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells. It has now been shown to be critical for the proper subcellular localization and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialized endoplasmic reticulum membranes, so the subcellular localization of IP3R is crucial for its proper function.


:

Pssm-ID: 464280  Cd Length: 145  Bit Score: 220.28  E-value: 6.10e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576410 148 HQKGRSMNSTGSGKSsgTVSSVSELLELYEEDPEEILYNLGFGRDEPDIASKIPSRFFNSSSFAKGIDIKVFLSAQMQRM 227
Cdd:pfam14722   1 LSRGTSFNSSHSTAS--TPQSISEWLEFWEEDPEEILLDLGFGADEPDICTRIPARFLGCPSAARGINIRVFLEAQKQRM 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462576410 228 EVENPNyaLTSRFRQIEVLTTVANAFSSLYSQVSGTPLQrigsMSSVTSNKETDPPPPLTRSNTANRLMKTLS 300
Cdd:pfam14722  79 DIENPN--LASRFRQLEVLDHVANAFSSLYSDVSITPVQ----AEEKSVGSEPQSPSVSETKEHRRRMGKLLS 145
SSFA2_C super family cl20656
Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the ...
 864-931 1.33e-31

Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the actin-interacting protein sperm-specific antigen 2.


The actual alignment was detected with superfamily member pfam14723:

Pssm-ID: 464281  Cd Length: 171  Bit Score: 121.56  E-value: 1.33e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462576410 864 TLSTHSVPNISGATCSAFASPFGCPYSHRHATYPYRVCSVNPPSAIEMQLRRVLHDIRNSLQNLSQFS 931
Cdd:pfam14723   1 TWSTHSVPNLSGAPCGAFYSPFSCPYSPRHQGPPHRGHSRNPPSTTEMQLRRVLHDIRNSVQNLSQYP 68
 
Name Accession Description Interval E-value
KRAP_IP3R_bind pfam14722
Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the ...
 148-300 6.10e-67

Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localized as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells. It has now been shown to be critical for the proper subcellular localization and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialized endoplasmic reticulum membranes, so the subcellular localization of IP3R is crucial for its proper function.


Pssm-ID: 464280  Cd Length: 145  Bit Score: 220.28  E-value: 6.10e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576410 148 HQKGRSMNSTGSGKSsgTVSSVSELLELYEEDPEEILYNLGFGRDEPDIASKIPSRFFNSSSFAKGIDIKVFLSAQMQRM 227
Cdd:pfam14722   1 LSRGTSFNSSHSTAS--TPQSISEWLEFWEEDPEEILLDLGFGADEPDICTRIPARFLGCPSAARGINIRVFLEAQKQRM 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462576410 228 EVENPNyaLTSRFRQIEVLTTVANAFSSLYSQVSGTPLQrigsMSSVTSNKETDPPPPLTRSNTANRLMKTLS 300
Cdd:pfam14722  79 DIENPN--LASRFRQLEVLDHVANAFSSLYSDVSITPVQ----AEEKSVGSEPQSPSVSETKEHRRRMGKLLS 145
SSFA2_C pfam14723
Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the ...
 864-931 1.33e-31

Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the actin-interacting protein sperm-specific antigen 2.


Pssm-ID: 464281  Cd Length: 171  Bit Score: 121.56  E-value: 1.33e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462576410 864 TLSTHSVPNISGATCSAFASPFGCPYSHRHATYPYRVCSVNPPSAIEMQLRRVLHDIRNSLQNLSQFS 931
Cdd:pfam14723   1 TWSTHSVPNLSGAPCGAFYSPFSCPYSPRHQGPPHRGHSRNPPSTTEMQLRRVLHDIRNSVQNLSQYP 68
 
Name Accession Description Interval E-value
KRAP_IP3R_bind pfam14722
Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the ...
 148-300 6.10e-67

Ki-ras-induced actin-interacting protein-IP3R-interacting domain; This family includes the N-terminus of the actin-interacting protein sperm-specific antigen 2, or KRAP (Ki-ras-induced actin-interacting protein). This region is found to be the residues that interact with inositol 1,4,5-trisphosphate receptor (IP3R). KRAP was first localized as a membrane-bound form with extracellular regions suggesting it might be involved in the regulation of filamentous actin and signals from the outside of the cells. It has now been shown to be critical for the proper subcellular localization and function of IP3R. Inositol 1,4,5-trisphosphate receptor functions as the Ca2+ release channel on specialized endoplasmic reticulum membranes, so the subcellular localization of IP3R is crucial for its proper function.


Pssm-ID: 464280  Cd Length: 145  Bit Score: 220.28  E-value: 6.10e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576410 148 HQKGRSMNSTGSGKSsgTVSSVSELLELYEEDPEEILYNLGFGRDEPDIASKIPSRFFNSSSFAKGIDIKVFLSAQMQRM 227
Cdd:pfam14722   1 LSRGTSFNSSHSTAS--TPQSISEWLEFWEEDPEEILLDLGFGADEPDICTRIPARFLGCPSAARGINIRVFLEAQKQRM 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462576410 228 EVENPNyaLTSRFRQIEVLTTVANAFSSLYSQVSGTPLQrigsMSSVTSNKETDPPPPLTRSNTANRLMKTLS 300
Cdd:pfam14722  79 DIENPN--LASRFRQLEVLDHVANAFSSLYSDVSITPVQ----AEEKSVGSEPQSPSVSETKEHRRRMGKLLS 145
SSFA2_C pfam14723
Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the ...
 864-931 1.33e-31

Sperm-specific antigen 2 C-terminus; This family includes the C-terminus of the actin-interacting protein sperm-specific antigen 2.


Pssm-ID: 464281  Cd Length: 171  Bit Score: 121.56  E-value: 1.33e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462576410 864 TLSTHSVPNISGATCSAFASPFGCPYSHRHATYPYRVCSVNPPSAIEMQLRRVLHDIRNSLQNLSQFS 931
Cdd:pfam14723   1 TWSTHSVPNLSGAPCGAFYSPFSCPYSPRHQGPPHRGHSRNPPSTTEMQLRRVLHDIRNSVQNLSQYP 68
Med14 pfam08638
Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects ...
 206-306 2.37e-03

Mediator complex subunit MED14; Saccharomyces cerevisiae RGR1 mediator complex subunit affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation. This subunit is also found in higher eukaryotes and Med14 is the agreed unified nomenclature for this subunit. Med14 is found in the tail region of Mediator.


Pssm-ID: 462543  Cd Length: 192  Bit Score: 40.18  E-value: 2.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462576410 206 NSSSFAKGIDIKVFLsaQMQRMEVEN-----------------PNYAL-TSrfrqIEVLTTvanafsslysqvsGTPLQr 267
Cdd:pfam08638  63 KAEDVSKLIDLLAFL--RQQNMAFEDaadalknmkrslvnarlPNPDLpTA----LEVLST-------------GRYPR- 122

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2462576410 268 igsMSsvTSNKETDPPPPLtrsnTANRLMKTLSKLNLCV 306
Cdd:pfam08638 123 ---LP--TLIYDIIPPPPL----TPKEILKTLRDLNTLL 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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