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Conserved domains on  [gi|2462576791|ref|XP_054199717|]
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DNA-binding protein RFX8 isoform X4 [Homo sapiens]

Protein Classification

RFX family transcription factor( domain architecture ID 8623)

RFX family transcription factor activates transcription by binding to the X-box in the promoter of target genes; similar to Candida albicans RFX-like DNA-binding protein RFX2

CATH:  1.10.10.10
Gene Ontology:  GO:0003700
PubMed:  8754849|8600444

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RFX_DNA_binding super family cl03504
RFX DNA-binding domain; RFX is a regulatory factor which binds to the X box of MHC class II ...
 23-67 5.56e-16

RFX DNA-binding domain; RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD).


The actual alignment was detected with superfamily member pfam02257:

Pssm-ID: 460512  Cd Length: 79  Bit Score: 72.58  E-value: 5.56e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2462576791  23 IQWLVDNFCICEECSVPRCLMYEIYVETCGQNTENQVNPATFGKC 67
Cdd:pfam02257   5 LQWLNANYEVAEGSSVPRSRVYAHYLSFCSKLGIKPLNAASFGKL 49
 
Name Accession Description Interval E-value
RFX_DNA_binding pfam02257
RFX DNA-binding domain; RFX is a regulatory factor which binds to the X box of MHC class II ...
 23-67 5.56e-16

RFX DNA-binding domain; RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD).


Pssm-ID: 460512  Cd Length: 79  Bit Score: 72.58  E-value: 5.56e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2462576791  23 IQWLVDNFCICEECSVPRCLMYEIYVETCGQNTENQVNPATFGKC 67
Cdd:pfam02257   5 LQWLNANYEVAEGSSVPRSRVYAHYLSFCSKLGIKPLNAASFGKL 49
 
Name Accession Description Interval E-value
RFX_DNA_binding pfam02257
RFX DNA-binding domain; RFX is a regulatory factor which binds to the X box of MHC class II ...
 23-67 5.56e-16

RFX DNA-binding domain; RFX is a regulatory factor which binds to the X box of MHC class II genes and is essential for their expression. The DNA-binding domain of RFX is the central domain of the protein and binds ssDNA as either a monomer or homodimer. It recognize X-boxes (DNA of the sequence 5'-GTNRCC(0-3N)RGYAAC-3', where N is any nucleotide, R is a purine and Y is a pyrimidine) using a highly conserved 76-residue DNA-binding domain (DBD).


Pssm-ID: 460512  Cd Length: 79  Bit Score: 72.58  E-value: 5.56e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 2462576791  23 IQWLVDNFCICEECSVPRCLMYEIYVETCGQNTENQVNPATFGKC 67
Cdd:pfam02257   5 LQWLNANYEVAEGSSVPRSRVYAHYLSFCSKLGIKPLNAASFGKL 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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