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Conserved domains on  [gi|2462577507|ref|XP_054200054|]
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THUMP domain-containing protein 2 isoform X3 [Homo sapiens]

Protein Classification

THUMP domain-containing protein( domain architecture ID 10184965)

THUMP domain-containing protein similar to human THUMP domain-containing protein 1 (THUMPD1) that functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation

CATH:  3.30.2300.10
Gene Ontology:  GO:0006400|GO:0003723
PubMed:  11295541
SCOP:  4002010

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
THUMP_AdoMetMT cd11715
THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Proteins of ...
18-76 3.60e-06

THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Proteins of this family contain an N-terminal THUMP domain and a C-terminal S-adenosylmethionine-dependent methyltransferase domain. Members have been implicated in the modification of 23S RNA m2G2445, a highly conserved modification in bacteria and in the m2G6 modification of tRNA. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


:

Pssm-ID: 212584  Cd Length: 152  Bit Score: 45.65  E-value: 3.60e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462577507  18 FFCTAGRGLEPFVMREVRArLAATQVEYISGKVFFTTcsDLNMLKK----LKSAERLFLLIKK 76
Cdd:cd11715     1 FFATCPPGLEELLAAELKA-LGAEDVEVGPGGVSFEG--DLEDAYRanlwLRTAHRVLLLLAE 60
 
Name Accession Description Interval E-value
THUMP_AdoMetMT cd11715
THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Proteins of ...
18-76 3.60e-06

THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Proteins of this family contain an N-terminal THUMP domain and a C-terminal S-adenosylmethionine-dependent methyltransferase domain. Members have been implicated in the modification of 23S RNA m2G2445, a highly conserved modification in bacteria and in the m2G6 modification of tRNA. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212584  Cd Length: 152  Bit Score: 45.65  E-value: 3.60e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462577507  18 FFCTAGRGLEPFVMREVRArLAATQVEYISGKVFFTTcsDLNMLKK----LKSAERLFLLIKK 76
Cdd:cd11715     1 FFATCPPGLEELLAAELKA-LGAEDVEVGPGGVSFEG--DLEDAYRanlwLRTAHRVLLLLAE 60
 
Name Accession Description Interval E-value
THUMP_AdoMetMT cd11715
THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Proteins of ...
18-76 3.60e-06

THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Proteins of this family contain an N-terminal THUMP domain and a C-terminal S-adenosylmethionine-dependent methyltransferase domain. Members have been implicated in the modification of 23S RNA m2G2445, a highly conserved modification in bacteria and in the m2G6 modification of tRNA. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets.


Pssm-ID: 212584  Cd Length: 152  Bit Score: 45.65  E-value: 3.60e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462577507  18 FFCTAGRGLEPFVMREVRArLAATQVEYISGKVFFTTcsDLNMLKK----LKSAERLFLLIKK 76
Cdd:cd11715     1 FFATCPPGLEELLAAELKA-LGAEDVEVGPGGVSFEG--DLEDAYRanlwLRTAHRVLLLLAE 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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