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Conserved domains on  [gi|2462578374|ref|XP_054200451|]
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CCR4-NOT transcription complex subunit 9 isoform X2 [Homo sapiens]

Protein Classification

Rcd1-like cell differentiation family protein( domain architecture ID 10513525)

Rcd1-like cell differentiation family protein such as CCR4-NOT transcription complex subunit 9 (CNOT9), which is a component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rcd1 pfam04078
Cell differentiation family, Rcd1-like; Two of the members in this family have been ...
 15-191 3.66e-128

Cell differentiation family, Rcd1-like; Two of the members in this family have been characterized as being involved in regulation of Ste11 regulated sex genes. Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.


:

Pssm-ID: 461160  Cd Length: 259  Bit Score: 361.13  E-value: 3.66e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578374  15 KEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALV 94
Cdd:pfam04078  44 QEIVSIYPLLSPPTLTERESNRVCNALALLQCVASHPETRSLFLRAHIPLYLYPFLNTTSKSRPFEYLRLTSLGVIGALV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578374  95 KTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSAR 174
Cdd:pfam04078 124 KTDDPEVINFLLDTEIVPLCLRIMESGSELSKTVATFILQKILSDDDGLNYICQTPDRFSAVAQVLNSMVVQLVEQPSPR 203

                         170
                  ....*....|....*..
gi 2462578374 175 LLKHVVRCYLRLSDNPR 191
Cdd:pfam04078 204 LLKHVIRCYLRLSDNPR 220
 
Name Accession Description Interval E-value
Rcd1 pfam04078
Cell differentiation family, Rcd1-like; Two of the members in this family have been ...
 15-191 3.66e-128

Cell differentiation family, Rcd1-like; Two of the members in this family have been characterized as being involved in regulation of Ste11 regulated sex genes. Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.


Pssm-ID: 461160  Cd Length: 259  Bit Score: 361.13  E-value: 3.66e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578374  15 KEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALV 94
Cdd:pfam04078  44 QEIVSIYPLLSPPTLTERESNRVCNALALLQCVASHPETRSLFLRAHIPLYLYPFLNTTSKSRPFEYLRLTSLGVIGALV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578374  95 KTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSAR 174
Cdd:pfam04078 124 KTDDPEVINFLLDTEIVPLCLRIMESGSELSKTVATFILQKILSDDDGLNYICQTPDRFSAVAQVLNSMVVQLVEQPSPR 203

                         170
                  ....*....|....*..
gi 2462578374 175 LLKHVVRCYLRLSDNPR 191
Cdd:pfam04078 204 LLKHVIRCYLRLSDNPR 220
RCD1 COG5209
Uncharacterized protein involved in cell differentiation/sexual development [General function ...
 15-195 1.72e-94

Uncharacterized protein involved in cell differentiation/sexual development [General function prediction only];


Pssm-ID: 227534  Cd Length: 315  Bit Score: 277.95  E-value: 1.72e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578374  15 KEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALV 94
Cdd:COG5209    95 QEIISVYPILSPSKLDERESNRVCNALNLLQCLASHPETKKVFLDAHIPLFLYPFLNTSSSNSKFEYLRLTSLGVIGALV 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578374  95 KTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSAR 174
Cdd:COG5209   175 KNDSQYVIKFLLTTEIVPLCLRIMELGSELSKTVAIFIFQKILGDDVGLQYICQTFERFYAVNLVLNSMVSQLVSLGSTR 254

                         170       180
                  ....*....|....*....|.
gi 2462578374 175 LLKHVVRCYLRLSDNPRFSDL 195
Cdd:COG5209   255 LLKHAIRCYLRLSDKPHARAL 275
 
Name Accession Description Interval E-value
Rcd1 pfam04078
Cell differentiation family, Rcd1-like; Two of the members in this family have been ...
 15-191 3.66e-128

Cell differentiation family, Rcd1-like; Two of the members in this family have been characterized as being involved in regulation of Ste11 regulated sex genes. Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation.


Pssm-ID: 461160  Cd Length: 259  Bit Score: 361.13  E-value: 3.66e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578374  15 KEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALV 94
Cdd:pfam04078  44 QEIVSIYPLLSPPTLTERESNRVCNALALLQCVASHPETRSLFLRAHIPLYLYPFLNTTSKSRPFEYLRLTSLGVIGALV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578374  95 KTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSAR 174
Cdd:pfam04078 124 KTDDPEVINFLLDTEIVPLCLRIMESGSELSKTVATFILQKILSDDDGLNYICQTPDRFSAVAQVLNSMVVQLVEQPSPR 203

                         170
                  ....*....|....*..
gi 2462578374 175 LLKHVVRCYLRLSDNPR 191
Cdd:pfam04078 204 LLKHVIRCYLRLSDNPR 220
RCD1 COG5209
Uncharacterized protein involved in cell differentiation/sexual development [General function ...
 15-195 1.72e-94

Uncharacterized protein involved in cell differentiation/sexual development [General function prediction only];


Pssm-ID: 227534  Cd Length: 315  Bit Score: 277.95  E-value: 1.72e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578374  15 KEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALV 94
Cdd:COG5209    95 QEIISVYPILSPSKLDERESNRVCNALNLLQCLASHPETKKVFLDAHIPLFLYPFLNTSSSNSKFEYLRLTSLGVIGALV 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462578374  95 KTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSAR 174
Cdd:COG5209   175 KNDSQYVIKFLLTTEIVPLCLRIMELGSELSKTVAIFIFQKILGDDVGLQYICQTFERFYAVNLVLNSMVSQLVSLGSTR 254

                         170       180
                  ....*....|....*....|.
gi 2462578374 175 LLKHVVRCYLRLSDNPRFSDL 195
Cdd:COG5209   255 LLKHAIRCYLRLSDKPHARAL 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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