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Conserved domains on  [gi|2462588340|ref|XP_054201792|]
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stabilin-1 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Link_Domain super family cl02612
The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive ...
 2176-2268 6.00e-50

The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor necrosis factor-stimulated gene-6. TSG-6 has a strong anti-inflammatory effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. This group also contains the link domains of the chondroitin sulfate proteoglycan core proteins (CSPG) including aggrecan, versican, neurocan, and brevican and the link domains of the vertebrate HAPLN (HA and proteoglycan binding link) protein family. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates in which other CSPGs substitute for aggregan might contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN gene family are physically linked adjacent to CSPG genes. TSG-6 contains a single link module which supports high affinity binding with HA. The functional HA-binding domain of CD44 is an extended domain comprised of a link module flanked with N-and C- extensions. These extensions are essential for folding and functional activity. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of the CSPG aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) which contains link modules 3 and 4 which lack HA-binding activity. HAPLNs contain two contiguous link modules.


The actual alignment was detected with superfamily member cd03515:

Pssm-ID: 470631  Cd Length: 93  Bit Score: 172.26  E-value: 6.00e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 2176 GVFHLQATSGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHLCLMGWLANGSTAHPVVFPVADCGNGRVGVVSLGA 2255
Cdd:cd03515      1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                           90
                   ....*....|...
gi 2462588340 2256 RKNLSERWDAYCF 2268
Cdd:cd03515     81 RLNLSERWDAYCY 93
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 496-643 1.63e-28

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


:

Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 113.85  E-value: 1.63e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  496 QAPSGTPGDPKRTIGQILASTEAFSRFETILENCGLPSILDGPGPFTVFAPSNEAVDSLRDGRLIYLFTAG-LSKLQELV 574
Cdd:COG2335     20 AAAEGAAMAPTKNIVETAANNPDFSTLVAALKAAGLVDTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPEnKATLTKIL 99

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462588340  575 RYHIYNhGQLTVEKLISKGRILTMANQVLAVNISeEGRILLGpeGVPLQRVDVMAANGVIHMLDGILLP 643
Cdd:COG2335    100 TYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVS-GGGVTVN--GANVITADIEASNGVIHVIDKVLLP 164
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1704-1834 3.59e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.49  E-value: 3.59e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 1704 GYKIFSGLLKVAGLLPLLREaSHRPFTMLWPTDAAFRALPPDRQAWLYheDHRDKLAAILRGHMIRNVeALASDLPNLGP 1783
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNG-SQGPFTVFAPTNEAFAKLPAGTLNFLL--KDKEQLKNLLKYHVVPGR-LTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462588340 1784 LRTMHGTPISFSCSRtrpGELMVgeDDARIVQRHLPFEGGLAYGIDQLLEP 1834
Cdd:pfam02469   78 LATLQGSKLRVNVTG---GSVTV--NGARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1574-1678 4.93e-26

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 105.03  E-value: 4.93e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 1574 KELKG-DGPFTIFVPHADLMSNLSQDELARIRAHRQL---VFRYHVVGCRrLRSEDLLEQGYATALSGHPLRFSEREGSI 1649
Cdd:pfam02469   17 DTLNGsQGPFTVFAPTNEAFAKLPAGTLNFLLKDKEQlknLLKYHVVPGR-LTSSDLKNGGTLATLQGSKLRVNVTGGSV 95

                           90       100
                   ....*....|....*....|....*....
gi 2462588340 1650 YLNDfARVVSSDHEAVNGILHFIDRVLLP 1678
Cdd:pfam02469   96 TVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 967-1088 7.80e-24

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


:

Pssm-ID: 396845  Cd Length: 123  Bit Score: 98.86  E-value: 7.80e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  967 AHFSIFYQWLKSAGI--TLP-ADRRVTALVPSEAAVRQLSPEDRAFWLQ-PRTLPNLVRAHFLQGALFEEELARlgGQEV 1042
Cdd:pfam02469    1 PGFSTFVALLKAAGLvdTLNgSQGPFTVFAPTNEAFAKLPAGTLNFLLKdKEQLKNLLKYHVVPGRLTSSDLKN--GGTL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2462588340 1043 ATLNPTTrWEIRNISGRVWVQNASVDVADLLATNGVLHILSQVLLP 1088
Cdd:pfam02469   79 ATLQGSK-LRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVLLP 123
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1427-1463 2.98e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 51.45  E-value: 2.98e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462588340 1427 CAHGHGGCSPHANCTKVaPGQRTCTCQDGYMGDGELC 1463
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2063-2098 1.09e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.90  E-value: 1.09e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462588340 2063 CQDGHGGCSEHANCSQVGTMVTCTCLPDYEGDGWSC 2098
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1512-1549 4.72e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 4.72e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462588340 1512 CSKNNGGCSPYATCKSTgDGQRTCTCDTAHTvGDGLTC 1549
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYT-GDGVTC 36
Fasciclin super family cl02663
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 393-490 7.07e-06

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


The actual alignment was detected with superfamily member pfam02469:

Pssm-ID: 470649  Cd Length: 123  Bit Score: 47.63  E-value: 7.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  393 TAGPFTVLVPSVSSFS--------SRTMNASLAQQLCRQHIIAGQHILEDTRTQQTRRwwTLAGQEITVTFnqftkysyk 464
Cdd:pfam02469   22 SQGPFTVFAPTNEAFAklpagtlnFLLKDKEQLKNLLKYHVVPGRLTSSDLKNGGTLA--TLQGSKLRVNV--------- 90

                           90       100
                   ....*....|....*....|....*....
gi 2462588340  465 ykDQPQQTFN---IYKANNIAANGVFHVV 490
Cdd:pfam02469   91 --TGGSVTVNgarVVQADIEATNGVIHVI 117
Fasciclin super family cl02663
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1107-1209 1.30e-05

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


The actual alignment was detected with superfamily member pfam02469:

Pssm-ID: 470649  Cd Length: 123  Bit Score: 46.86  E-value: 1.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 1107 PAFSLFRELLQHHGLVPQIEAATA-YTIFVPTNRSLEA--QGNSSHLDADT------VRHHVVLGeALSMETLRKGGHRN 1177
Cdd:pfam02469    1 PGFSTFVALLKAAGLVDTLNGSQGpFTVFAPTNEAFAKlpAGTLNFLLKDKeqlknlLKYHVVPG-RLTSSDLKNGGTLA 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462588340 1178 SLLGPAhwIVFYNHSGQPEVNHVPLEGPMLEA 1209
Cdd:pfam02469   80 TLQGSK--LRVNVTGGSVTVNGARVVQADIEA 109
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1469-1506 3.20e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.97  E-value: 3.20e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462588340 1469 CLIHHGGCHIHAECIPTGPQqVSCSCREGYSGDGIrTC 1506
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGS-FTCTCNDGYTGDGV-TC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2104-2141 2.11e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.66  E-value: 2.11e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462588340 2104 CTDGHrGGCSEHANCLSTGlNTRRCECHAGYVGDGLQC 2141
Cdd:pfam12947    1 CSDNN-GGCHPNATCTNTG-GSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 914-945 3.88e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.89  E-value: 3.88e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462588340  914 GGCHTDALCSYVgPGQSRCTCKLGFAGDGYQC 945
Cdd:pfam12947    6 GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 831-859 7.06e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.12  E-value: 7.06e-04
                           10        20
                   ....*....|....*....|....*....
gi 2462588340  831 CHLHARCVSQEGVARCRCLDGFEGDGFSC 859
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 super family cl48154
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 865-902 2.88e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


The actual alignment was detected with superfamily member pfam12947:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.58  E-value: 2.88e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462588340  865 CSHpDRGGCSENAECVPgSLGTHHCTCHKGWSGDGRVC 902
Cdd:pfam12947    1 CSD-NNGGCHPNATCTN-TGGSFTCTCNDGYTGDGVTC 36
EGF_3 super family cl48154
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1392-1421 3.31e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


The actual alignment was detected with superfamily member pfam12947:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.19  E-value: 3.31e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462588340 1392 CDPNANCVQdSAGASTCACAAGYSGNGIFC 1421
Cdd:pfam12947    8 CHPNATCTN-TGGSFTCTCNDGYTGDGVTC 36
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1960-1989 3.68e-03

Laminin-type epidermal growth factor-like domai;


:

Pssm-ID: 214543  Cd Length: 46  Bit Score: 37.29  E-value: 3.68e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 2462588340  1960 SGQCLCRSGFAGTACELCAPGAFGPHCQAC 1989
Cdd:smart00180   17 TGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
 
Name Accession Description Interval E-value
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 2176-2268 6.00e-50

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


Pssm-ID: 239592  Cd Length: 93  Bit Score: 172.26  E-value: 6.00e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 2176 GVFHLQATSGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHLCLMGWLANGSTAHPVVFPVADCGNGRVGVVSLGA 2255
Cdd:cd03515      1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                           90
                   ....*....|...
gi 2462588340 2256 RKNLSERWDAYCF 2268
Cdd:cd03515     81 RLNLSERWDAYCY 93
LINK smart00445
Link (Hyaluronan-binding);
2174-2269 1.11e-36

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 134.39  E-value: 1.11e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  2174 RAGVFHLQATsGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHLCLMGWLANGSTAHPVVFPVADCGNGRVGVVSL 2253
Cdd:smart00445    1 DGGVFHVEKN-GRYKLTFAEAREACRAQGATLATVGQLYAAWQDGFDTCDAGWLADGSVRYPIITPRPRCGGNLPGVRQY 79

                            90
                    ....*....|....*.
gi 2462588340  2254 GARKNLSeRWDAYCFR 2269
Cdd:smart00445   80 GFPDPTS-RYDAYCFN 94
Xlink pfam00193
Extracellular link domain;
2176-2268 1.18e-35

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 131.16  E-value: 1.18e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 2176 GVFHLQAtSGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHLCLMGWLANGSTAHPVVFPVADCGNGRVGVVSLGA 2255
Cdd:pfam00193    1 GVFHLES-PGRYKLTFQEAQAACAALGATLATPEQLYAAWKAGLDTCDAGWLADGTVRYPITTPRPNCGGNMPGVRQYGF 79

                           90
                   ....*....|...
gi 2462588340 2256 RKNLSERWDAYCF 2268
Cdd:pfam00193   80 RDPLSERYDAYCY 92
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 496-643 1.63e-28

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 113.85  E-value: 1.63e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  496 QAPSGTPGDPKRTIGQILASTEAFSRFETILENCGLPSILDGPGPFTVFAPSNEAVDSLRDGRLIYLFTAG-LSKLQELV 574
Cdd:COG2335     20 AAAEGAAMAPTKNIVETAANNPDFSTLVAALKAAGLVDTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPEnKATLTKIL 99

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462588340  575 RYHIYNhGQLTVEKLISKGRILTMANQVLAVNISeEGRILLGpeGVPLQRVDVMAANGVIHMLDGILLP 643
Cdd:COG2335    100 TYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVS-GGGVTVN--GANVITADIEASNGVIHVIDKVLLP 164
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1704-1834 3.59e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.49  E-value: 3.59e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 1704 GYKIFSGLLKVAGLLPLLREaSHRPFTMLWPTDAAFRALPPDRQAWLYheDHRDKLAAILRGHMIRNVeALASDLPNLGP 1783
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNG-SQGPFTVFAPTNEAFAKLPAGTLNFLL--KDKEQLKNLLKYHVVPGR-LTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462588340 1784 LRTMHGTPISFSCSRtrpGELMVgeDDARIVQRHLPFEGGLAYGIDQLLEP 1834
Cdd:pfam02469   78 LATLQGSKLRVNVTG---GSVTV--NGARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1574-1678 4.93e-26

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 105.03  E-value: 4.93e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 1574 KELKG-DGPFTIFVPHADLMSNLSQDELARIRAHRQL---VFRYHVVGCRrLRSEDLLEQGYATALSGHPLRFSEREGSI 1649
Cdd:pfam02469   17 DTLNGsQGPFTVFAPTNEAFAKLPAGTLNFLLKDKEQlknLLKYHVVPGR-LTSSDLKNGGTLATLQGSKLRVNVTGGSV 95

                           90       100
                   ....*....|....*....|....*....
gi 2462588340 1650 YLNDfARVVSSDHEAVNGILHFIDRVLLP 1678
Cdd:pfam02469   96 TVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 967-1088 7.80e-24

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 98.86  E-value: 7.80e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  967 AHFSIFYQWLKSAGI--TLP-ADRRVTALVPSEAAVRQLSPEDRAFWLQ-PRTLPNLVRAHFLQGALFEEELARlgGQEV 1042
Cdd:pfam02469    1 PGFSTFVALLKAAGLvdTLNgSQGPFTVFAPTNEAFAKLPAGTLNFLLKdKEQLKNLLKYHVVPGRLTSSDLKN--GGTL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2462588340 1043 ATLNPTTrWEIRNISGRVWVQNASVDVADLLATNGVLHILSQVLLP 1088
Cdd:pfam02469   79 ATLQGSK-LRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 519-643 1.83e-20

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 89.23  E-value: 1.83e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  519 FSRFETILENCGLPSILDGP-GPFTVFAPSNEAVDSLRDGRLIYLFtAGLSKLQELVRYHIYNhGQLTVEKLISKGRILT 597
Cdd:pfam02469    3 FSTFVALLKAAGLVDTLNGSqGPFTVFAPTNEAFAKLPAGTLNFLL-KDKEQLKNLLKYHVVP-GRLTSSDLKNGGTLAT 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2462588340  598 MANQVLAVNIsEEGRILLgpEGVPLQRVDVMAANGVIHMLDGILLP 643
Cdd:pfam02469   81 LQGSKLRVNV-TGGSVTV--NGARVVQADIEATNGVIHVIDKVLLP 123
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1583-1679 5.26e-20

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 87.03  E-value: 5.26e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  1583 TIFVPHADLMSNLSQDELARIRAHRQLVFRYHVVGcRRLRSEDLLEQGYATALSGHPLRFSERE--GSIYLNDfARVVSS 1660
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLADKLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGgsGTVTVNG-ARIVEA 78

                            90
                    ....*....|....*....
gi 2462588340  1661 DHEAVNGILHFIDRVLLPP 1679
Cdd:smart00554   79 DIAATNGVVHVIDRVLLPP 97
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
542-644 6.27e-20

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 86.65  E-value: 6.27e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340   542 TVFAPSNEAVDSLRDGRliYLFTAglSKLQELVRYHIYNhGQLTVEKLISKGRILTMANQVLAVNISEeGRILLGPEGVP 621
Cdd:smart00554    1 TVFAPTDEAFQKLPPDL--NSLLA--DKLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSG-GSGTVTVNGAR 74

                            90       100
                    ....*....|....*....|...
gi 2462588340   622 LQRVDVMAANGVIHMLDGILLPP 644
Cdd:smart00554   75 IVEADIAATNGVVHVIDRVLLPP 97
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1730-1835 1.94e-19

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 85.11  E-value: 1.94e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  1730 TMLWPTDAAFRALPPDRQAWLyhedhRDKLAAILRGHMIrNVEALASDLPNLGPLRTMHGTPISFSCSRTRPgelMVGED 1809
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLL-----ADKLKNLLLYHVV-PGRLSSADLLNGGTLPTLAGSKLRITRSGGSG---TVTVN 71

                            90       100
                    ....*....|....*....|....*.
gi 2462588340  1810 DARIVQRHLPFEGGLAYGIDQLLEPP 1835
Cdd:smart00554   72 GARIVEADIAATNGVVHVIDRVLLPP 97
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1576-1678 3.15e-19

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 86.88  E-value: 3.15e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 1576 LKGDGPFTIFVPH------------ADLMSNLSQDELARIrahrqlvFRYHVVGcRRLRSEDLLEQGYATALSGHPLRFS 1643
Cdd:COG2335     59 LSGEGPFTVFAPTdaafaalpagtlDALLKPENKATLTKI-------LTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVT 130

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2462588340 1644 EREGSIYLNDfARVVSSDHEAVNGILHFIDRVLLP 1678
Cdd:COG2335    131 VSGGGVTVNG-ANVITADIEASNGVIHVIDKVLLP 164
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 963-1088 4.07e-16

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 78.02  E-value: 4.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  963 LEANAHFSIFYQWLKSAGI--TLPADRRVTALVPSEAAVRQLSPEDRAFWLQP---RTLPNLVRAHFLQGALFEEELARl 1037
Cdd:COG2335     37 AANNPDFSTLVAALKAAGLvdTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPenkATLTKILTYHVVPGKVTAADLKD- 115

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462588340 1038 gGQEVATLNPTTrWEIRNISGRVWVQNASVDVADLLATNGVLHILSQVLLP 1088
Cdd:COG2335    116 -GKTLTTLQGQT-LTVTVSGGGVTVNGANVITADIEASNGVIHVIDKVLLP 164
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1684-1834 8.07e-16

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 77.25  E-value: 8.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 1684 WEPDDAPIPRRNVTAAAQGFG-YKIFSGLLKVAGLLPLLREAshRPFTMLWPTDAAFRALPPD-RQAWLYHEDhRDKLAA 1761
Cdd:COG2335     21 AAEGAAMAPTKNIVETAANNPdFSTLVAALKAAGLVDTLSGE--GPFTVFAPTDAAFAALPAGtLDALLKPEN-KATLTK 97

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462588340 1762 ILRGHMIRNvEALASDLPNLGPLRTMHGTPISFSCSrtrPGELMVGedDARIVQRHLPFEGGLAYGIDQLLEP 1834
Cdd:COG2335     98 ILTYHVVPG-KVTAADLKDGKTLTTLQGQTLTVTVS---GGGVTVN--GANVITADIEASNGVIHVIDKVLLP 164
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
990-1089 2.66e-15

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 73.55  E-value: 2.66e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340   990 TALVPSEAAVRQLSPEDRAFWLQprTLPNLVRAHFLQGALFEEELarLGGQEVATLNPTT-RWEIRNISGRVWVQNASVD 1068
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLAD--KLKNLLLYHVVPGRLSSADL--LNGGTLPTLAGSKlRITRSGGSGTVTVNGARIV 76

                            90       100
                    ....*....|....*....|.
gi 2462588340  1069 VADLLATNGVLHILSQVLLPP 1089
Cdd:smart00554   77 EADIAATNGVVHVIDRVLLPP 97
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1427-1463 2.98e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 51.45  E-value: 2.98e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462588340 1427 CAHGHGGCSPHANCTKVaPGQRTCTCQDGYMGDGELC 1463
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2063-2098 1.09e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.90  E-value: 1.09e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462588340 2063 CQDGHGGCSEHANCSQVGTMVTCTCLPDYEGDGWSC 2098
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1512-1549 4.72e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 4.72e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462588340 1512 CSKNNGGCSPYATCKSTgDGQRTCTCDTAHTvGDGLTC 1549
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYT-GDGVTC 36
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 393-490 7.07e-06

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 47.63  E-value: 7.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  393 TAGPFTVLVPSVSSFS--------SRTMNASLAQQLCRQHIIAGQHILEDTRTQQTRRwwTLAGQEITVTFnqftkysyk 464
Cdd:pfam02469   22 SQGPFTVFAPTNEAFAklpagtlnFLLKDKEQLKNLLKYHVVPGRLTSSDLKNGGTLA--TLQGSKLRVNV--------- 90

                           90       100
                   ....*....|....*....|....*....
gi 2462588340  465 ykDQPQQTFN---IYKANNIAANGVFHVV 490
Cdd:pfam02469   91 --TGGSVTVNgarVVQADIEATNGVIHVI 117
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1107-1209 1.30e-05

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 46.86  E-value: 1.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 1107 PAFSLFRELLQHHGLVPQIEAATA-YTIFVPTNRSLEA--QGNSSHLDADT------VRHHVVLGeALSMETLRKGGHRN 1177
Cdd:pfam02469    1 PGFSTFVALLKAAGLVDTLNGSQGpFTVFAPTNEAFAKlpAGTLNFLLKDKeqlknlLKYHVVPG-RLTSSDLKNGGTLA 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462588340 1178 SLLGPAhwIVFYNHSGQPEVNHVPLEGPMLEA 1209
Cdd:pfam02469   80 TLQGSK--LRVNVTGGSVTVNGARVVQADIEA 109
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1469-1506 3.20e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.97  E-value: 3.20e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462588340 1469 CLIHHGGCHIHAECIPTGPQqVSCSCREGYSGDGIrTC 1506
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGS-FTCTCNDGYTGDGV-TC 36
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 380-490 7.90e-05

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 45.28  E-value: 7.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  380 VAMMDQ-GCREILTTAGPFTVLVPSVSSFS----------SRTMNASLAQQLCRQHIIAGQHILEDTRTQQTRRwwTLAG 448
Cdd:COG2335     47 VAALKAaGLVDTLSGEGPFTVFAPTDAAFAalpagtldalLKPENKATLTKILTYHVVPGKVTAADLKDGKTLT--TLQG 124

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2462588340  449 QEITVTFNqftkysykyKDQPQ-QTFNIYKANNIAANGVFHVV 490
Cdd:COG2335    125 QTLTVTVS---------GGGVTvNGANVITADIEASNGVIHVI 158
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2104-2141 2.11e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.66  E-value: 2.11e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462588340 2104 CTDGHrGGCSEHANCLSTGlNTRRCECHAGYVGDGLQC 2141
Cdd:pfam12947    1 CSDNN-GGCHPNATCTNTG-GSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 914-945 3.88e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.89  E-value: 3.88e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462588340  914 GGCHTDALCSYVgPGQSRCTCKLGFAGDGYQC 945
Cdd:pfam12947    6 GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 831-859 7.06e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.12  E-value: 7.06e-04
                           10        20
                   ....*....|....*....|....*....
gi 2462588340  831 CHLHARCVSQEGVARCRCLDGFEGDGFSC 859
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 865-902 2.88e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.58  E-value: 2.88e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462588340  865 CSHpDRGGCSENAECVPgSLGTHHCTCHKGWSGDGRVC 902
Cdd:pfam12947    1 CSD-NNGGCHPNATCTN-TGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1392-1421 3.31e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.19  E-value: 3.31e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462588340 1392 CDPNANCVQdSAGASTCACAAGYSGNGIFC 1421
Cdd:pfam12947    8 CHPNATCTN-TGGSFTCTCNDGYTGDGVTC 36
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1960-1989 3.68e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 37.29  E-value: 3.68e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 2462588340  1960 SGQCLCRSGFAGTACELCAPGAFGPHCQAC 1989
Cdd:smart00180   17 TGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1107-1181 5.02e-03

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 40.27  E-value: 5.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 1107 PAFSLFRELLQHHGLVPQIEAATAYTIFVPTNRSLEAqgnsshLDADTV----------------RHHVVLGEALSmETL 1170
Cdd:COG2335     41 PDFSTLVAALKAAGLVDTLSGEGPFTVFAPTDAAFAA------LPAGTLdallkpenkatltkilTYHVVPGKVTA-ADL 113

                           90
                   ....*....|.
gi 2462588340 1171 RKGGHRNSLLG 1181
Cdd:COG2335    114 KDGKTLTTLQG 124
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1132-1221 5.53e-03

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 38.50  E-value: 5.53e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  1132 TIFVPTN---RSLEAQGNSSHLDADT--VRHHVVLGeALSMETLRKGGHRNSLLGPAHWIVFYNHSGQPEVNHVPLEGPM 1206
Cdd:smart00554    1 TVFAPTDeafQKLPPDLNSLLADKLKnlLLYHVVPG-RLSSADLLNGGTLPTLAGSKLRITRSGGSGTVTVNGARIVEAD 79

                            90
                    ....*....|....*
gi 2462588340  1207 LEAPGRSLIGLSGVL 1221
Cdd:smart00554   80 IAATNGVVHVIDRVL 94
 
Name Accession Description Interval E-value
Link_domain_TSG_6_like cd03515
This is the extracellular link domain of the type found in human TSG-6. The link domain is a ...
 2176-2268 6.00e-50

This is the extracellular link domain of the type found in human TSG-6. The link domain is a hyaluronan (HA)-binding domain. TSG-6 is the protein product of tumor necrosis factor-stimulated gene-6. TSG-6 is up-regulated in inflammatory lesions and in the ovary during ovulation. It has a strong anti-inflammatory and chondroprotective effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. Also included in this group are the stabilins: stabilin-1 (FEEL-1, CLEVER-1) and stabilin-2 (FEEL-2). Stabilin-2 functions as the major liver and lymph node-scavenging receptor for HA and related glycosaminoglycans. Stabilin-2 is a scavenger receptor with a broad range of ligands including advanced glycation end (AGE) products, acetylated low density lipoprotein and procollagen peptides. In contrast, stabilin-1 does not bind HA, but binds acetylated low density lipoprotein and AGEs with lower affinity. As AGEs accumulate in vascular tissues during aging and diabetes, these receptors may be implicated in the pathologies of these states. Both stabilins are present in the early endocytic pathway in hepatic sinusoidal epithelium associating with clathrin/AP-2. Stabilin-1 is expressed in macrophages. Stabilin-2 is absent from the latter. In macrophages: stabilin-1 is involved in trafficking between early/sorting endosomes and the trans-Golgi network. Stabilin-1 has also been implicated in angiogenesis and possibly leucocyte trafficking. Both stabilins bind gram-positive and gram-negative bacteria. TSG-6 and stabilins contain a single link module which supports high affinity binding to HA.


Pssm-ID: 239592  Cd Length: 93  Bit Score: 172.26  E-value: 6.00e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 2176 GVFHLQATSGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHLCLMGWLANGSTAHPVVFPVADCGNGRVGVVSLGA 2255
Cdd:cd03515      1 GVFHLRSRSGKYKLTYTEAKAACEAEGAHLATYSQLSAAQQLGFHLCAAGWLAKGRVGYPIVFPSANCGFGHVGIVDYGP 80

                           90
                   ....*....|...
gi 2462588340 2256 RKNLSERWDAYCF 2268
Cdd:cd03515     81 RLNLSERWDAYCY 93
LINK smart00445
Link (Hyaluronan-binding);
2174-2269 1.11e-36

Link (Hyaluronan-binding);


Pssm-ID: 214667  Cd Length: 94  Bit Score: 134.39  E-value: 1.11e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  2174 RAGVFHLQATsGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHLCLMGWLANGSTAHPVVFPVADCGNGRVGVVSL 2253
Cdd:smart00445    1 DGGVFHVEKN-GRYKLTFAEAREACRAQGATLATVGQLYAAWQDGFDTCDAGWLADGSVRYPIITPRPRCGGNLPGVRQY 79

                            90
                    ....*....|....*.
gi 2462588340  2254 GARKNLSeRWDAYCFR 2269
Cdd:smart00445   80 GFPDPTS-RYDAYCFN 94
Xlink pfam00193
Extracellular link domain;
2176-2268 1.18e-35

Extracellular link domain;


Pssm-ID: 459706  Cd Length: 92  Bit Score: 131.16  E-value: 1.18e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 2176 GVFHLQAtSGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHLCLMGWLANGSTAHPVVFPVADCGNGRVGVVSLGA 2255
Cdd:pfam00193    1 GVFHLES-PGRYKLTFQEAQAACAALGATLATPEQLYAAWKAGLDTCDAGWLADGTVRYPITTPRPNCGGNMPGVRQYGF 79

                           90
                   ....*....|...
gi 2462588340 2256 RKNLSERWDAYCF 2268
Cdd:pfam00193   80 RDPLSERYDAYCY 92
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 496-643 1.63e-28

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 113.85  E-value: 1.63e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  496 QAPSGTPGDPKRTIGQILASTEAFSRFETILENCGLPSILDGPGPFTVFAPSNEAVDSLRDGRLIYLFTAG-LSKLQELV 574
Cdd:COG2335     20 AAAEGAAMAPTKNIVETAANNPDFSTLVAALKAAGLVDTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPEnKATLTKIL 99

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462588340  575 RYHIYNhGQLTVEKLISKGRILTMANQVLAVNISeEGRILLGpeGVPLQRVDVMAANGVIHMLDGILLP 643
Cdd:COG2335    100 TYHVVP-GKVTAADLKDGKTLTTLQGQTLTVTVS-GGGVTVN--GANVITADIEASNGVIHVIDKVLLP 164
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1704-1834 3.59e-27

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 108.49  E-value: 3.59e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 1704 GYKIFSGLLKVAGLLPLLREaSHRPFTMLWPTDAAFRALPPDRQAWLYheDHRDKLAAILRGHMIRNVeALASDLPNLGP 1783
Cdd:pfam02469    2 GFSTFVALLKAAGLVDTLNG-SQGPFTVFAPTNEAFAKLPAGTLNFLL--KDKEQLKNLLKYHVVPGR-LTSSDLKNGGT 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462588340 1784 LRTMHGTPISFSCSRtrpGELMVgeDDARIVQRHLPFEGGLAYGIDQLLEP 1834
Cdd:pfam02469   78 LATLQGSKLRVNVTG---GSVTV--NGARVVQADIEATNGVIHVIDKVLLP 123
Link_Domain cd01102
The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive ...
 2176-2268 9.02e-27

The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor necrosis factor-stimulated gene-6. TSG-6 has a strong anti-inflammatory effect in models of acute inflammation and autoimmune arthritis and plays an essential role in female fertility. This group also contains the link domains of the chondroitin sulfate proteoglycan core proteins (CSPG) including aggrecan, versican, neurocan, and brevican and the link domains of the vertebrate HAPLN (HA and proteoglycan binding link) protein family. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates in which other CSPGs substitute for aggregan might contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN gene family are physically linked adjacent to CSPG genes. TSG-6 contains a single link module which supports high affinity binding with HA. The functional HA-binding domain of CD44 is an extended domain comprised of a link module flanked with N-and C- extensions. These extensions are essential for folding and functional activity. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of the CSPG aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) which contains link modules 3 and 4 which lack HA-binding activity. HAPLNs contain two contiguous link modules.


Pssm-ID: 238534  Cd Length: 92  Bit Score: 105.96  E-value: 9.02e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 2176 GVFHLQATSGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHLCLMGWLANGSTAHPVVFPVADCGNGRVGVVSLGA 2255
Cdd:cd01102      1 VVFHLESQNGRYKLTFAEAALACKARGAHLATPGQLEAAWQDGFDVCTAGWLADGSVRYPIVTSRPNCGGRNPGVRSYGN 80

                           90
                   ....*....|...
gi 2462588340 2256 RKNlSERWDAYCF 2268
Cdd:cd01102     81 PAP-SGRYDAYCF 92
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1574-1678 4.93e-26

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 105.03  E-value: 4.93e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 1574 KELKG-DGPFTIFVPHADLMSNLSQDELARIRAHRQL---VFRYHVVGCRrLRSEDLLEQGYATALSGHPLRFSEREGSI 1649
Cdd:pfam02469   17 DTLNGsQGPFTVFAPTNEAFAKLPAGTLNFLLKDKEQlknLLKYHVVPGR-LTSSDLKNGGTLATLQGSKLRVNVTGGSV 95

                           90       100
                   ....*....|....*....|....*....
gi 2462588340 1650 YLNDfARVVSSDHEAVNGILHFIDRVLLP 1678
Cdd:pfam02469   96 TVNG-ARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 967-1088 7.80e-24

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 98.86  E-value: 7.80e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  967 AHFSIFYQWLKSAGI--TLP-ADRRVTALVPSEAAVRQLSPEDRAFWLQ-PRTLPNLVRAHFLQGALFEEELARlgGQEV 1042
Cdd:pfam02469    1 PGFSTFVALLKAAGLvdTLNgSQGPFTVFAPTNEAFAKLPAGTLNFLLKdKEQLKNLLKYHVVPGRLTSSDLKN--GGTL 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2462588340 1043 ATLNPTTrWEIRNISGRVWVQNASVDVADLLATNGVLHILSQVLLP 1088
Cdd:pfam02469   79 ATLQGSK-LRVNVTGGSVTVNGARVVQADIEATNGVIHVIDKVLLP 123
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 519-643 1.83e-20

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 89.23  E-value: 1.83e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  519 FSRFETILENCGLPSILDGP-GPFTVFAPSNEAVDSLRDGRLIYLFtAGLSKLQELVRYHIYNhGQLTVEKLISKGRILT 597
Cdd:pfam02469    3 FSTFVALLKAAGLVDTLNGSqGPFTVFAPTNEAFAKLPAGTLNFLL-KDKEQLKNLLKYHVVP-GRLTSSDLKNGGTLAT 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 2462588340  598 MANQVLAVNIsEEGRILLgpEGVPLQRVDVMAANGVIHMLDGILLP 643
Cdd:pfam02469   81 LQGSKLRVNV-TGGSVTV--NGARVVQADIEATNGVIHVIDKVLLP 123
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1583-1679 5.26e-20

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 87.03  E-value: 5.26e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  1583 TIFVPHADLMSNLSQDELARIRAHRQLVFRYHVVGcRRLRSEDLLEQGYATALSGHPLRFSERE--GSIYLNDfARVVSS 1660
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLADKLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSGgsGTVTVNG-ARIVEA 78

                            90
                    ....*....|....*....
gi 2462588340  1661 DHEAVNGILHFIDRVLLPP 1679
Cdd:smart00554   79 DIAATNGVVHVIDRVLLPP 97
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
542-644 6.27e-20

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 86.65  E-value: 6.27e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340   542 TVFAPSNEAVDSLRDGRliYLFTAglSKLQELVRYHIYNhGQLTVEKLISKGRILTMANQVLAVNISEeGRILLGPEGVP 621
Cdd:smart00554    1 TVFAPTDEAFQKLPPDL--NSLLA--DKLKNLLLYHVVP-GRLSSADLLNGGTLPTLAGSKLRITRSG-GSGTVTVNGAR 74

                            90       100
                    ....*....|....*....|...
gi 2462588340   622 LQRVDVMAANGVIHMLDGILLPP 644
Cdd:smart00554   75 IVEADIAATNGVVHVIDRVLLPP 97
Link_domain_HAPLN_module_1 cd03518
Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins ...
 2177-2268 8.34e-20

Link_domain_HAPLN_module_1; this link domain is found in the first link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239595  Cd Length: 95  Bit Score: 86.33  E-value: 8.34e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 2177 VFHLQATSGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHLCLMGWLANGSTAHPVVFPVADCGNGRV--GVVSLG 2254
Cdd:cd03518      2 VFPYQPRLGRYNLNFHEAQQACEEQDATLASFEQLYQAWTEGLDWCNAGWLSDGTVQYPITKPREPCGGKRTvpGLRSYG 81

                           90
                   ....*....|....
gi 2462588340 2255 ARKNLSERWDAYCF 2268
Cdd:cd03518     82 ERDKMLSRYDAFCF 95
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1730-1835 1.94e-19

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 85.11  E-value: 1.94e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  1730 TMLWPTDAAFRALPPDRQAWLyhedhRDKLAAILRGHMIrNVEALASDLPNLGPLRTMHGTPISFSCSRTRPgelMVGED 1809
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLL-----ADKLKNLLLYHVV-PGRLSSADLLNGGTLPTLAGSKLRITRSGGSG---TVTVN 71

                            90       100
                    ....*....|....*....|....*.
gi 2462588340  1810 DARIVQRHLPFEGGLAYGIDQLLEPP 1835
Cdd:smart00554   72 GARIVEADIAATNGVVHVIDRVLLPP 97
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1576-1678 3.15e-19

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 86.88  E-value: 3.15e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 1576 LKGDGPFTIFVPH------------ADLMSNLSQDELARIrahrqlvFRYHVVGcRRLRSEDLLEQGYATALSGHPLRFS 1643
Cdd:COG2335     59 LSGEGPFTVFAPTdaafaalpagtlDALLKPENKATLTKI-------LTYHVVP-GKVTAADLKDGKTLTTLQGQTLTVT 130

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2462588340 1644 EREGSIYLNDfARVVSSDHEAVNGILHFIDRVLLP 1678
Cdd:COG2335    131 VSGGGVTVNG-ANVITADIEASNGVIHVIDKVLLP 164
Link_domain_CSPGs_modules_2_4 cd03520
Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules ...
 2177-2268 4.54e-19

Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. Aggrecan in addition contains a second globular domain (G2) having link modules 3 and 4 which lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239597  Cd Length: 96  Bit Score: 84.29  E-value: 4.54e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 2177 VFHlqaTSGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHLCLMGWLANGSTAHPVVFPVADCGNGRVGVVSLGAR 2256
Cdd:cd03520      2 VFY---ATAPEKFTFQEARAECRSLGAVLATTGQLYAAWRQGLDQCDPGWLADGSVRYPISTPRPQCGGGLPGVRTLYRF 78

                           90
                   ....*....|....*...
gi 2462588340 2257 KNL------SERWDAYCF 2268
Cdd:cd03520     79 PNQtgfpdpHSRFDAYCF 96
Link_domain_CD44_like cd03516
This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates ...
 2175-2272 6.69e-17

This domain is a hyaluronan (HA)-binding domain. It is found in CD44 receptor and mediates adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It also plays an important role in arteriogenesis. The functional HA-binding domain of CD44 is an extended domain comprised of a single link module flanked with N-and C- extensions. These extensions are essential for folding and for functional activity. This group also contains the cell surface retention sequence (CRS) binding protein-1 (CRSBP-1) and lymph vessel endothelial receptor-1 (LYVE-1). CRSBP-1 is a cell surface binding protein for the CRS motif of PDGF-BB (platelet-derived growth factor-BB) and is responsible for the cell surface retention of PDGF-BB in SSV-transformed cells. CRSBP-1 may play a role in autocrine regulation of cell growth mediated by CRS containing growth regulators. LYVE-1 is preferentially expressed on the lymphatic endothelium and is used as a molecular marker for the detection and characterization of lymphatic vessels in tumors.


Pssm-ID: 239593  Cd Length: 144  Bit Score: 79.81  E-value: 6.69e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 2175 AGVFHLQaTSGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHLCLMGWLANGSTAHPVVFPVADCGNGRVGVVSLG 2254
Cdd:cd03516      6 MGVFLVE-KNGRYSLNFTEAKEACRALGLTLASKAQVETALKFGFETCRYGWVEDGFVVIPRIDPNPLCGKNGTGVYILN 84

                           90
                   ....*....|....*...
gi 2462588340 2255 ArkNLSERWDAYCFRVQD 2272
Cdd:cd03516     85 S--NLSSRYDAYCYNSSD 100
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 963-1088 4.07e-16

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 78.02  E-value: 4.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  963 LEANAHFSIFYQWLKSAGI--TLPADRRVTALVPSEAAVRQLSPEDRAFWLQP---RTLPNLVRAHFLQGALFEEELARl 1037
Cdd:COG2335     37 AANNPDFSTLVAALKAAGLvdTLSGEGPFTVFAPTDAAFAALPAGTLDALLKPenkATLTKILTYHVVPGKVTAADLKD- 115

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462588340 1038 gGQEVATLNPTTrWEIRNISGRVWVQNASVDVADLLATNGVLHILSQVLLP 1088
Cdd:COG2335    116 -GKTLTTLQGQT-LTVTVSGGGVTVNGANVITADIEASNGVIHVIDKVLLP 164
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1684-1834 8.07e-16

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 77.25  E-value: 8.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 1684 WEPDDAPIPRRNVTAAAQGFG-YKIFSGLLKVAGLLPLLREAshRPFTMLWPTDAAFRALPPD-RQAWLYHEDhRDKLAA 1761
Cdd:COG2335     21 AAEGAAMAPTKNIVETAANNPdFSTLVAALKAAGLVDTLSGE--GPFTVFAPTDAAFAALPAGtLDALLKPEN-KATLTK 97

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462588340 1762 ILRGHMIRNvEALASDLPNLGPLRTMHGTPISFSCSrtrPGELMVGedDARIVQRHLPFEGGLAYGIDQLLEP 1834
Cdd:COG2335     98 ILTYHVVPG-KVTAADLKDGKTLTTLQGQTLTVTVS---GGGVTVN--GANVITADIEASNGVIHVIDKVLLP 164
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
990-1089 2.66e-15

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 73.55  E-value: 2.66e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340   990 TALVPSEAAVRQLSPEDRAFWLQprTLPNLVRAHFLQGALFEEELarLGGQEVATLNPTT-RWEIRNISGRVWVQNASVD 1068
Cdd:smart00554    1 TVFAPTDEAFQKLPPDLNSLLAD--KLKNLLLYHVVPGRLSSADL--LNGGTLPTLAGSKlRITRSGGSGTVTVNGARIV 76

                            90       100
                    ....*....|....*....|.
gi 2462588340  1069 VADLLATNGVLHILSQVLLPP 1089
Cdd:smart00554   77 EADIAATNGVVHVIDRVLLPP 97
Link_domain_CSPGs_modules_1_3 cd03517
Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third ...
 2177-2268 9.68e-15

Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan (HA)-binding domain. CSPGs are characterized by an N-terminal globular domain (G1 domain) containing two contiguous link modules (modules 1 and 2). Both link modules of the G1 domain of aggrecan are involved in interaction with HA. In addition, aggrecan contains a second globular domain (G2) which contains link modules 3 and 4. G2 appears to lack HA-binding activity. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 239594  Cd Length: 95  Bit Score: 71.67  E-value: 9.68e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 2177 VFHLQATSGPYGLNFSEAEAACEAQGAVLASFPQLSAAQQLGFHLCLMGWLANGSTAHPVVFPVADC---GNGRVGVVSL 2253
Cdd:cd03517      2 VFHYRDATARYALTFPRAQRACLDISAQIATPEQLLAAYEDGFEQCDAGWLADQTVRYPIQTPREGCygdMDGFPGVRNY 81

                           90
                   ....*....|....*
gi 2462588340 2254 GARkNLSERWDAYCF 2268
Cdd:cd03517     82 GVR-DPDELYDVYCY 95
Link_domain_HAPLN_module_2 cd03519
Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins ...
 2176-2268 4.79e-14

Link_domain_HAPLN_module_2; this link domain is found in the second link module of proteins similar to the vertebrate HAPLN (hyaluronan/HA and proteoglycan binding link) protein family which includes cartilage link protein. The link domain is a HA-binding domain. HAPLNs contain two contiguous link modules. Both link modules of cartilage link protein are involved in interaction with HA. In cartilage, a chondroitin sulfate proteoglycan core protein (CSPG) aggrecan forms cartilage link protein stabilized aggregates with HA. These aggregates contribute to the tissue's load bearing properties. Aggregates with other CSPGs substituting for aggregan may contribute to the structural integrity of many different tissues. Members of the vertebrate HAPLN gene family are physically linked adjacent to CSPG genes.


Pssm-ID: 239596  Cd Length: 91  Bit Score: 69.76  E-value: 4.79e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 2176 GVFHLQAtsgPYGLNFSEAEAACEAQGAVLASFPQLSAAQQL-GFHLCLMGWLANGSTAHPVVFPVADCGNGRVGVVSLG 2254
Cdd:cd03519      1 GVFYLLH---PGKLTFSEAVAACQRDGAQIAKVGQLFAAWKFhGLDRCDAGWLADGSVRYPISRPRPRCGPLEPGVRSFG 77

                           90
                   ....*....|....
gi 2462588340 2255 ARKNLSERWDAYCF 2268
Cdd:cd03519     78 FPDKKHKLYGVYCY 91
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1427-1463 2.98e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 51.45  E-value: 2.98e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462588340 1427 CAHGHGGCSPHANCTKVaPGQRTCTCQDGYMGDGELC 1463
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2063-2098 1.09e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 49.90  E-value: 1.09e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462588340 2063 CQDGHGGCSEHANCSQVGTMVTCTCLPDYEGDGWSC 2098
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1512-1549 4.72e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 4.72e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462588340 1512 CSKNNGGCSPYATCKSTgDGQRTCTCDTAHTvGDGLTC 1549
Cdd:pfam12947    1 CSDNNGGCHPNATCTNT-GGSFTCTCNDGYT-GDGVTC 36
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 393-490 7.07e-06

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 47.63  E-value: 7.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  393 TAGPFTVLVPSVSSFS--------SRTMNASLAQQLCRQHIIAGQHILEDTRTQQTRRwwTLAGQEITVTFnqftkysyk 464
Cdd:pfam02469   22 SQGPFTVFAPTNEAFAklpagtlnFLLKDKEQLKNLLKYHVVPGRLTSSDLKNGGTLA--TLQGSKLRVNV--------- 90

                           90       100
                   ....*....|....*....|....*....
gi 2462588340  465 ykDQPQQTFN---IYKANNIAANGVFHVV 490
Cdd:pfam02469   91 --TGGSVTVNgarVVQADIEATNGVIHVI 117
Fasciclin pfam02469
Fasciclin domain; This extracellular domain is found repeated four times in grasshopper ...
 1107-1209 1.30e-05

Fasciclin domain; This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria.


Pssm-ID: 396845  Cd Length: 123  Bit Score: 46.86  E-value: 1.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 1107 PAFSLFRELLQHHGLVPQIEAATA-YTIFVPTNRSLEA--QGNSSHLDADT------VRHHVVLGeALSMETLRKGGHRN 1177
Cdd:pfam02469    1 PGFSTFVALLKAAGLVDTLNGSQGpFTVFAPTNEAFAKlpAGTLNFLLKDKeqlknlLKYHVVPG-RLTSSDLKNGGTLA 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 2462588340 1178 SLLGPAhwIVFYNHSGQPEVNHVPLEGPMLEA 1209
Cdd:pfam02469   80 TLQGSK--LRVNVTGGSVTVNGARVVQADIEA 109
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1469-1506 3.20e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 42.97  E-value: 3.20e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462588340 1469 CLIHHGGCHIHAECIPTGPQqVSCSCREGYSGDGIrTC 1506
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGS-FTCTCNDGYTGDGV-TC 36
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 380-490 7.90e-05

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 45.28  E-value: 7.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  380 VAMMDQ-GCREILTTAGPFTVLVPSVSSFS----------SRTMNASLAQQLCRQHIIAGQHILEDTRTQQTRRwwTLAG 448
Cdd:COG2335     47 VAALKAaGLVDTLSGEGPFTVFAPTDAAFAalpagtldalLKPENKATLTKILTYHVVPGKVTAADLKDGKTLT--TLQG 124

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2462588340  449 QEITVTFNqftkysykyKDQPQ-QTFNIYKANNIAANGVFHVV 490
Cdd:COG2335    125 QTLTVTVS---------GGGVTvNGANVITADIEASNGVIHVI 158
Link_domain_KIAA0527_like cd03521
Link_domain_KIAA0527_like; this domain is found in the human protein KIAA0527. Sequence-wise, ...
 2177-2267 1.17e-04

Link_domain_KIAA0527_like; this domain is found in the human protein KIAA0527. Sequence-wise, it is highly similar to the link domain. The link domain is a hyaluronan-binding (HA) domain. KIAA0527 contains a single link module. The KIAA0527 gene was originally cloned from human brain tissue.


Pssm-ID: 239598  Cd Length: 95  Bit Score: 43.38  E-value: 1.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 2177 VFHLQATSGPYGLNFSEAEAACEAQGAVLASFPQLS-AAQQLGFHLCLMGWLANGSTAHPVVFP-VADCGNGRVGVVSLG 2254
Cdd:cd03521      2 LFVLELENGSQGLGLRAARQSCASLGARLASAAELRrAVVECFFSACARGWLADGTVGTTVCNPvVAEALKAVDVKVEIE 81

                           90
                   ....*....|...
gi 2462588340 2255 ARKNLSERWDAYC 2267
Cdd:cd03521     82 TNPIPFAHYNALC 94
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 2104-2141 2.11e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.66  E-value: 2.11e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462588340 2104 CTDGHrGGCSEHANCLSTGlNTRRCECHAGYVGDGLQC 2141
Cdd:pfam12947    1 CSDNN-GGCHPNATCTNTG-GSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 914-945 3.88e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.89  E-value: 3.88e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2462588340  914 GGCHTDALCSYVgPGQSRCTCKLGFAGDGYQC 945
Cdd:pfam12947    6 GGCHPNATCTNT-GGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 831-859 7.06e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.12  E-value: 7.06e-04
                           10        20
                   ....*....|....*....|....*....
gi 2462588340  831 CHLHARCVSQEGVARCRCLDGFEGDGFSC 859
Cdd:pfam12947    8 CHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 865-902 2.88e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.58  E-value: 2.88e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462588340  865 CSHpDRGGCSENAECVPgSLGTHHCTCHKGWSGDGRVC 902
Cdd:pfam12947    1 CSD-NNGGCHPNATCTN-TGGSFTCTCNDGYTGDGVTC 36
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1392-1421 3.31e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 37.19  E-value: 3.31e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462588340 1392 CDPNANCVQdSAGASTCACAAGYSGNGIFC 1421
Cdd:pfam12947    8 CHPNATCTN-TGGSFTCTCNDGYTGDGVTC 36
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1960-1989 3.68e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 37.29  E-value: 3.68e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 2462588340  1960 SGQCLCRSGFAGTACELCAPGAFGPHCQAC 1989
Cdd:smart00180   17 TGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
FAS1 COG2335
Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function ...
 1107-1181 5.02e-03

Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only];


Pssm-ID: 441906 [Multi-domain]  Cd Length: 164  Bit Score: 40.27  E-value: 5.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340 1107 PAFSLFRELLQHHGLVPQIEAATAYTIFVPTNRSLEAqgnsshLDADTV----------------RHHVVLGEALSmETL 1170
Cdd:COG2335     41 PDFSTLVAALKAAGLVDTLSGEGPFTVFAPTDAAFAA------LPAGTLdallkpenkatltkilTYHVVPGKVTA-ADL 113

                           90
                   ....*....|.
gi 2462588340 1171 RKGGHRNSLLG 1181
Cdd:COG2335    114 KDGKTLTTLQG 124
FAS1 smart00554
Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;
1132-1221 5.53e-03

Four repeated domains in the Fasciclin I family of proteins, present in many other contexts;


Pssm-ID: 214719  Cd Length: 97  Bit Score: 38.50  E-value: 5.53e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462588340  1132 TIFVPTN---RSLEAQGNSSHLDADT--VRHHVVLGeALSMETLRKGGHRNSLLGPAHWIVFYNHSGQPEVNHVPLEGPM 1206
Cdd:smart00554    1 TVFAPTDeafQKLPPDLNSLLADKLKnlLLYHVVPG-RLSSADLLNGGTLPTLAGSKLRITRSGGSGTVTVNGARIVEAD 79

                            90
                    ....*....|....*
gi 2462588340  1207 LEAPGRSLIGLSGVL 1221
Cdd:smart00554   80 IAATNGVVHVIDRVL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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