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Conserved domains on  [gi|2462591222|ref|XP_054203181|]
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YEATS domain-containing protein 2 isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YEATS super family cl38902
YEATS domain family, chromatin reader proteins; The YEATS family is named for several family ...
 217-277 7.01e-39

YEATS domain family, chromatin reader proteins; The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein, YEATS2, Drosophila D12, and others. DNA regulation by chromatin through histone post-translational modification and other mechanisms involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state and stimulates transcriptional activity through preferential interactions with crotonylated lysines on histones.


The actual alignment was detected with superfamily member cd16907:

Pssm-ID: 365778  Cd Length: 123  Bit Score: 140.79  E-value: 7.01e-39
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462591222  217 KEPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHR 277
Cdd:cd16907     63 TKPPFHLTRRGWGEFPVRVQLHFKDPRNKPVDIIHNLKLDRTYTGLQTLGAETVVDVELDR 123
DUF5585 super family cl39316
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 813-1063 1.07e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


The actual alignment was detected with superfamily member pfam17823:

Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 49.96  E-value: 1.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591222  813 SPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTTLFTQAAHGGQASLMKISDSTLKTVPATSQLSKPGTTmlr 892
Cdd:pfam17823  122 SPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTA--- 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591222  893 VAGGVITTATSPAVALSANGPAQQSEGMAPVSSSTVSSVTKTSGQQQVCVSQATVGTCKAATPTVVSATSLVPTPNPISG 972
Cdd:pfam17823  199 ASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHAR 278

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591222  973 KATVSGLLKIHSSQSSP-----------------QQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKPPAILP 1035
Cdd:pfam17823  279 RLSPAKHMPSDTMARNPaapmgaqaqgpiiqvstDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEP 358

                          250       260
                   ....*....|....*....|....*....
gi 2462591222 1036 VAAPTPVVPSS-APAAVAKVKTEPETPGP 1063
Cdd:pfam17823  359 SASPVPVLHTSmIPEVEATSPTTQPSPLL 387
 
Name Accession Description Interval E-value
YEATS_YEATS2_like cd16907
YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with ...
 217-277 7.01e-39

YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with a preference for recognition of histone H3 crotonylation on lysine 27 (H3K27crHistone crotonylation upregulates gene expression in an AF9-dependent manner. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341126  Cd Length: 123  Bit Score: 140.79  E-value: 7.01e-39
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462591222  217 KEPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHR 277
Cdd:cd16907     63 TKPPFHLTRRGWGEFPVRVQLHFKDPRNKPVDIIHNLKLDRTYTGLQTLGAETVVDVELDR 123
YEATS pfam03366
YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and ...
 217-256 9.40e-16

YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. This family also contains the GAS41 protein. All these proteins are thought to have a transcription stimulatory activity


Pssm-ID: 460899  Cd Length: 80  Bit Score: 73.26  E-value: 9.40e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462591222  217 KEPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLD 256
Cdd:pfam03366   40 KKPPFEVTETGWGEFEIRIKIYFKDKDEKPVTIYHDLKLH 79
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 813-1063 1.07e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 49.96  E-value: 1.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591222  813 SPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTTLFTQAAHGGQASLMKISDSTLKTVPATSQLSKPGTTmlr 892
Cdd:pfam17823  122 SPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTA--- 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591222  893 VAGGVITTATSPAVALSANGPAQQSEGMAPVSSSTVSSVTKTSGQQQVCVSQATVGTCKAATPTVVSATSLVPTPNPISG 972
Cdd:pfam17823  199 ASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHAR 278

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591222  973 KATVSGLLKIHSSQSSP-----------------QQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKPPAILP 1035
Cdd:pfam17823  279 RLSPAKHMPSDTMARNPaapmgaqaqgpiiqvstDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEP 358

                          250       260
                   ....*....|....*....|....*....
gi 2462591222 1036 VAAPTPVVPSS-APAAVAKVKTEPETPGP 1063
Cdd:pfam17823  359 SASPVPVLHTSmIPEVEATSPTTQPSPLL 387
TFG3 COG5033
Transcription initiation factor IIF, auxiliary subunit [Transcription];
216-282 7.44e-04

Transcription initiation factor IIF, auxiliary subunit [Transcription];


Pssm-ID: 227366 [Multi-domain]  Cd Length: 225  Bit Score: 42.48  E-value: 7.44e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462591222  216 SKEPPFHLTRRGWGEFPVRVQVHFKDSQN-KRIDIIHNLKLDrtytglqTLGAETVVDVELHRHSLGE 282
Cdd:COG5033     72 IESPPFEIKETGWGEFDIQIKIFFAEKAGeKTIHFYLHFGDE-------PYAVDEPVDIPVNRPDLTS 132
 
Name Accession Description Interval E-value
YEATS_YEATS2_like cd16907
YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with ...
 217-277 7.01e-39

YEATS domain found in YEATS2 and Drosophila D12; YEATS2 is a YEATS domain reader protein with a preference for recognition of histone H3 crotonylation on lysine 27 (H3K27crHistone crotonylation upregulates gene expression in an AF9-dependent manner. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341126  Cd Length: 123  Bit Score: 140.79  E-value: 7.01e-39
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462591222  217 KEPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHR 277
Cdd:cd16907     63 TKPPFHLTRRGWGEFPVRVQLHFKDPRNKPVDIIHNLKLDRTYTGLQTLGAETVVDVELDR 123
YEATS pfam03366
YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and ...
 217-256 9.40e-16

YEATS family; We have named this family the YEATS family, after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. This family also contains the GAS41 protein. All these proteins are thought to have a transcription stimulatory activity


Pssm-ID: 460899  Cd Length: 80  Bit Score: 73.26  E-value: 9.40e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462591222  217 KEPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLD 256
Cdd:pfam03366   40 KKPPFEVTETGWGEFEIRIKIYFKDKDEKPVTIYHDLKLH 79
YEATS cd16887
YEATS domain family, chromatin reader proteins; The YEATS family is named for several family ...
 215-278 3.45e-15

YEATS domain family, chromatin reader proteins; The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein, YEATS2, Drosophila D12, and others. DNA regulation by chromatin through histone post-translational modification and other mechanisms involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state and stimulates transcriptional activity through preferential interactions with crotonylated lysines on histones.


Pssm-ID: 341123  Cd Length: 120  Bit Score: 73.08  E-value: 3.45e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462591222  215 VSKEPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHRH 278
Cdd:cd16887     57 VVTDPPFEVEEVGWGEFPIEIKIYFKDSNEKPVTLSHFLKLHPDGSPLKKPVVVSEKYDEIVFR 120
YEATS_TFIID14_like cd16910
YEATS domain found in transcription initiation factor TFIID subunit 14 and similar proteins; ...
 218-255 1.94e-10

YEATS domain found in transcription initiation factor TFIID subunit 14 and similar proteins; YEATS domain containing proteins, which include Transcription initiation factor TFIID subunits 14 and 14b of Arabidopsis, shown to be part of the TFIID general transcriptional regulator complex in a two-hybrid screen. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341129  Cd Length: 131  Bit Score: 59.90  E-value: 1.94e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462591222  218 EPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKL 255
Cdd:cd16910     62 EPPFEVTETGWGEFEIGITIHFKDDAEKPVELTHPLKL 99
YEATS_GAS41_like cd16909
YEATS domain found in YEATS domain-containing protein 4 and similar proteins; glioma amplified ...
 215-272 8.59e-08

YEATS domain found in YEATS domain-containing protein 4 and similar proteins; glioma amplified sequence 41 (GAS41, also known as, YEATS domain-containing protein 4, NuMA-binding protein 1 ) is a YEATS domain family protein that is amplified and acts as an oncogene in human glioma. GAS41 is a YEATS domain family protein and has been shown to interact with the general transcription factor TFIIF via the YEATS domain. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341128  Cd Length: 137  Bit Score: 52.64  E-value: 8.59e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462591222  215 VSKEPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLqTLGAETVVD 272
Cdd:cd16909     62 VVTKPPYEVTETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNL-MLGKKTLVS 118
YEATS_Taf14_like cd16905
YEATS domain found in Taf14 and similar proteins; Taf14 has been identified as a component of ...
 205-253 5.47e-06

YEATS domain found in Taf14 and similar proteins; Taf14 has been identified as a component of TFIIF and TFIID transcription factor complexes, various chromatin-remodeling complexes (such as SWI/SNF, INO80, and RSC) and the NuA3 histone acetyltransferase complex. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. Specifically, Taf14 has been show to be a reader of lysine crotonylation, associated with active gene promoters and enhancers and binding acetyllysine on in histone H3. The YEATS family is named for several family members: 'YNK7', 'ENL', 'AF-9', and 'TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341124  Cd Length: 118  Bit Score: 46.79  E-value: 5.47e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 2462591222  205 FVKKTIVVgnvsKEPPFHLTRRGWGEFPVRVQVHFKDSQNKRIdIIHNL 253
Cdd:cd16905     58 FENPIRTF----KKPPFRLEEKGWGEFDMKIVLHFLDNGGEFT-ITHDL 101
YEATS_Yaf9_like cd16908
YEATS domain found in Yaf9 and similar proteins; Yaf9 is a YEATS domain family protein ...
 219-255 5.47e-06

YEATS domain found in Yaf9 and similar proteins; Yaf9 is a YEATS domain family protein essential in the function the NuA4 histone acetyltransferase complex and the SWR1-C ATP-dependent chromatin remodeling complex. Yaf9 shares structural similarity with histone chaperone Asf1, both exhibit histone H3 and H4 binding in vitro, and evidence supports both play a role in the same histone acetylation mechanism. DNA regulation by chromatin thru histone post-translational modification and other mechanism involves complexes with write, eraser and reader functions. YEATS domains act as readers of the chromatin state, and stimulate transcriptional activity, thru preferential interactions with crotonylated lysines on histones. The YEATS family is named for several family members: `YNK7', `ENL', `AF-9', and `TFIIF small subunit', and also contains the GAS41 protein.


Pssm-ID: 341127  Cd Length: 145  Bit Score: 47.66  E-value: 5.47e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462591222  219 PPFHLTRRGWGEFPVRVQVHFKD-SQNKRIDIIHNLKL 255
Cdd:cd16908     68 PPFEVTETGWGEFEIQIKIYFVPeANEKPITLYHMLKL 105
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 813-1063 1.07e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 49.96  E-value: 1.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591222  813 SPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTTLFTQAAHGGQASLMKISDSTLKTVPATSQLSKPGTTmlr 892
Cdd:pfam17823  122 SPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTA--- 198

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591222  893 VAGGVITTATSPAVALSANGPAQQSEGMAPVSSSTVSSVTKTSGQQQVCVSQATVGTCKAATPTVVSATSLVPTPNPISG 972
Cdd:pfam17823  199 ASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHAR 278

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591222  973 KATVSGLLKIHSSQSSP-----------------QQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKPPAILP 1035
Cdd:pfam17823  279 RLSPAKHMPSDTMARNPaapmgaqaqgpiiqvstDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEP 358

                          250       260
                   ....*....|....*....|....*....
gi 2462591222 1036 VAAPTPVVPSS-APAAVAKVKTEPETPGP 1063
Cdd:pfam17823  359 SASPVPVLHTSmIPEVEATSPTTQPSPLL 387
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 834-1062 2.49e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 48.42  E-value: 2.49e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591222  834 STSSAQGQQTLKVISGQKTTLFTqaahGGQASLMKISDSTLKTVPATSQLSKPGTTmlrvaGGVITTATSPAVALSANGP 913
Cdd:pfam17823   52 NKSSEQ*NFCAATAAPAPVTLTK----GTSAAHLNSTEVTAEHTPHGTDLSEPATR-----EGAADGAASRALAAAASSS 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591222  914 AQQSEGMAPVSSSTVSSVTKTSGQQQVCVSQATVGTcKAATPTVVSATSLVPTPNPISGKATVSGllKIHSSQSSPQQAV 993
Cdd:pfam17823  123 PSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAP-RAAIAAASAPHAASPAPRTAASSTTAAS--STTAASSAPTTAA 199

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462591222  994 LTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKPPAILPVAAPTPVVPSSAPAAVAKVKTEPETPG 1062
Cdd:pfam17823  200 SSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAG 268
TFG3 COG5033
Transcription initiation factor IIF, auxiliary subunit [Transcription];
216-282 7.44e-04

Transcription initiation factor IIF, auxiliary subunit [Transcription];


Pssm-ID: 227366 [Multi-domain]  Cd Length: 225  Bit Score: 42.48  E-value: 7.44e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462591222  216 SKEPPFHLTRRGWGEFPVRVQVHFKDSQN-KRIDIIHNLKLDrtytglqTLGAETVVDVELHRHSLGE 282
Cdd:COG5033     72 IESPPFEIKETGWGEFDIQIKIFFAEKAGeKTIHFYLHFGDE-------PYAVDEPVDIPVNRPDLTS 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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