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Conserved domains on  [gi|2462591830|ref|XP_054203472|]
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protein SEC13 homolog isoform X4 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
28-292 1.35e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.11  E-value: 1.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830  28 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 107
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830 108 SVNSVCWAPHdyGLILACGSSDGAISLltYTGEGQWEVKKInNAHTIGCNAVSWapavvpgslidHPSGQkpnyikRFAS 187
Cdd:COG2319   206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAF-----------SPDGR------LLAS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830 188 GGCDNLIKLWkeeeDGQWKEE-QKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddassNTWSPKLLHKFN- 265
Cdd:COG2319   264 GSADGTVRLW----DLATGELlRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTg 328

                         250       260
                  ....*....|....*....|....*....
gi 2462591830 266 --DVVWHVSWSITANILAVSGGDNKVTLW 292
Cdd:COG2319   329 htGAVRSVAFSPDGKTLASGSDDGTVRLW 357
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
28-292 1.35e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.11  E-value: 1.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830  28 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 107
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830 108 SVNSVCWAPHdyGLILACGSSDGAISLltYTGEGQWEVKKInNAHTIGCNAVSWapavvpgslidHPSGQkpnyikRFAS 187
Cdd:COG2319   206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAF-----------SPDGR------LLAS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830 188 GGCDNLIKLWkeeeDGQWKEE-QKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddassNTWSPKLLHKFN- 265
Cdd:COG2319   264 GSADGTVRLW----DLATGELlRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTg 328

                         250       260
                  ....*....|....*....|....*....
gi 2462591830 266 --DVVWHVSWSITANILAVSGGDNKVTLW 292
Cdd:COG2319   329 htGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-292 1.08e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.05  E-value: 1.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830  13 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGgqILIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWREE 92
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830  93 NGtwEKSHEHAGHDSSVNSVCWAPHDYglILACGSSDGAISLltytgegqWEVKKIN-----NAHTIGCNAVSWAPAvvp 167
Cdd:cd00200    82 TG--ECVRTLTGHTSYVSSVAFSPDGR--ILSSSSRDKTIKV--------WDVETGKclttlRGHTDWVNSVAFSPD--- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830 168 gslidhpsgqkpnyiKRFASGGC-DNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 246
Cdd:cd00200   147 ---------------GTFVASSSqDGTIKLW---DLRTGKCVATLTGHTGEVNSVAFSPD----GEKLLSSSSDGTIKLW 204

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2462591830 247 tcdDASSNTWSpKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 292
Cdd:cd00200   205 ---DLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 52-89 3.60e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.60e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462591830   52 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 89
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 14-93 1.69e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.01  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830  14 SHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQIL--IAD----LRGHEGPVWQVAWaHPMYGNILASCSYDRKV 86
Cdd:PTZ00420   72 GHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVkeIKDpqciLKGHKKKISIIDW-NPMNYYIMCSSGFDSFV 150


                  ....*..
gi 2462591830  87 IIWREEN 93
Cdd:PTZ00420  151 NIWDIEN 157
WD40 pfam00400
WD domain, G-beta repeat;
205-246 6.33e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 6.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462591830 205 WKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 246
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
28-292 1.35e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.11  E-value: 1.35e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830  28 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 107
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830 108 SVNSVCWAPHdyGLILACGSSDGAISLltYTGEGQWEVKKInNAHTIGCNAVSWapavvpgslidHPSGQkpnyikRFAS 187
Cdd:COG2319   206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAF-----------SPDGR------LLAS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830 188 GGCDNLIKLWkeeeDGQWKEE-QKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddassNTWSPKLLHKFN- 265
Cdd:COG2319   264 GSADGTVRLW----DLATGELlRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTg 328

                         250       260
                  ....*....|....*....|....*....
gi 2462591830 266 --DVVWHVSWSITANILAVSGGDNKVTLW 292
Cdd:COG2319   329 htGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
28-292 3.29e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.26  E-value: 3.29e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830  28 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGTWEKSHEhaGHDS 107
Cdd:COG2319   174 GKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGKLLRTLT--GHSG 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830 108 SVNSVCWAPHdyGLILACGSSDGAISLLTYTGegqWEVKKINNAHTIGCNAVSWapavvpgslidHPSGqkpnyiKRFAS 187
Cdd:COG2319   248 SVRSVAFSPD--GRLLASGSADGTVRLWDLAT---GELLRTLTGHSGGVNSVAF-----------SPDG------KLLAS 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830 188 GGCDNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIWtcddassNTWSPKLLHKFN-- 265
Cdd:COG2319   306 GSDDGTVRLW---DLATGKLLRTLTGHTGAVRSVAFSPD----GKTLASGSDDGTVRLW-------DLATGELLRTLTgh 371

                         250       260
                  ....*....|....*....|....*...
gi 2462591830 266 -DVVWHVSWSITANILAVSGGDNKVTLW 292
Cdd:COG2319   372 tGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
13-292 3.33e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.56  E-value: 3.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830  13 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREE 92
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL--LLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRLWDLA 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830  93 NGtwEKSHEHAGHDSSVNSVCWAPhDyGLILACGSSDGAISLL-TYTGEGQWEVKkinnAHTIGCNAVSWApavvpgsli 171
Cdd:COG2319   151 TG--KLLRTLTGHSGAVTSVAFSP-D-GKLLASGSDDGTVRLWdLATGKLLRTLT----GHTGAVRSVAFS--------- 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830 172 dhPSGQkpnyikRFASGGCDNLIKLWKEEedgQWKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcdDA 251
Cdd:COG2319   214 --PDGK------LLASGSADGTVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPD-G---RLLASGSADGTVRLW---DL 275

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 2462591830 252 SSNTWsPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 292
Cdd:COG2319   276 ATGEL-LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-292 1.08e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.05  E-value: 1.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830  13 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGgqILIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWREE 92
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830  93 NGtwEKSHEHAGHDSSVNSVCWAPHDYglILACGSSDGAISLltytgegqWEVKKIN-----NAHTIGCNAVSWAPAvvp 167
Cdd:cd00200    82 TG--ECVRTLTGHTSYVSSVAFSPDGR--ILSSSSRDKTIKV--------WDVETGKclttlRGHTDWVNSVAFSPD--- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830 168 gslidhpsgqkpnyiKRFASGGC-DNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 246
Cdd:cd00200   147 ---------------GTFVASSSqDGTIKLW---DLRTGKCVATLTGHTGEVNSVAFSPD----GEKLLSSSSDGTIKLW 204

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 2462591830 247 tcdDASSNTWSpKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 292
Cdd:cd00200   205 ---DLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-293 4.83e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 4.83e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830  10 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWaHPMyGNILASCSYDRKVIIW 89
Cdd:cd00200    45 RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVW 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830  90 REENGtwEKSHEHAGHDSSVNSVCWAPHdyGLILACGSSDGAISLltytgegqWEVKKIN-----NAHTIGCNAVSWapa 164
Cdd:cd00200   121 DVETG--KCLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKL--------WDLRTGKcvatlTGHTGEVNSVAF--- 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830 165 vvpgslidHPSGqkpnyiKRFASGGCDNLIKLWkEEEDGQWKEEqkLEAHSDWVRDVAWAPSIGLptstIASCSQDGRVF 244
Cdd:cd00200   186 --------SPDG------EKLLSSSSDGTIKLW-DLSTGKCLGT--LRGHENGVNSVAFSPDGYL----LASGSEDGTIR 244

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462591830 245 IWtcddassNTWSPKLLHKF---NDVVWHVSWSITANILAVSGGDNKVTLWK 293
Cdd:cd00200   245 VW-------DLRTGECVQTLsghTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
28-292 1.23e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 1.23e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830  28 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGTWEksHEHAGHDS 107
Cdd:COG2319    48 GARLAAGAGDLTLLLLDAAAGA--LLATLLGHTAAVLSVAFSPD--GRLLASASADGTVRLWDLATGLLL--RTLTGHTG 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830 108 SVNSVCWAPHdyGLILACGSSDGAISLL-TYTGEGQWEVKkinnAHTIGCNAVSWapavvpgslidHPSGqkpnyiKRFA 186
Cdd:COG2319   122 AVRSVAFSPD--GKTLASGSADGTVRLWdLATGKLLRTLT----GHSGAVTSVAF-----------SPDG------KLLA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830 187 SGGCDNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcdDASSNTWsPKLLHKFND 266
Cdd:COG2319   179 SGSDDGTVRLW---DLATGKLLRTLTGHTGAVRSVAFSPD-G---KLLASGSADGTVRLW---DLATGKL-LRTLTGHSG 247

                         250       260
                  ....*....|....*....|....*.
gi 2462591830 267 VVWHVSWSITANILAVSGGDNKVTLW 292
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
13-90 1.28e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 1.28e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462591830  13 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWR 90
Cdd:COG2319   327 TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--LLRTLTGHTGAVTSVAFSPD--GRTLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 52-89 3.60e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.60e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462591830   52 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 89
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 204-246 1.56e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.56e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 2462591830  204 QWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 246
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD----GKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 14-93 1.69e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.01  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462591830  14 SHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQIL--IAD----LRGHEGPVWQVAWaHPMYGNILASCSYDRKV 86
Cdd:PTZ00420   72 GHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVkeIKDpqciLKGHKKKISIIDW-NPMNYYIMCSSGFDSFV 150


                  ....*..
gi 2462591830  87 IIWREEN 93
Cdd:PTZ00420  151 NIWDIEN 157
WD40 pfam00400
WD domain, G-beta repeat;
205-246 6.33e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 6.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462591830 205 WKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 246
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
52-89 6.46e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 6.46e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2462591830  52 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 89
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP--DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 95-134 3.20e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 3.20e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462591830   95 TWEKSHEHAGHDSSVNSVCWAPHdyGLILACGSSDGAISL 134
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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