|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
46-1090 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 1600.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 46 SKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVG-MNCREVTFVPGLYKIFDEILVNAADNKQRDKN-- 122
Cdd:PTZ00108 1 KKNKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYDEEKNrMVYKTITYVPGLYKIFDEILVNAADNKARDKGgh 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 123 -MTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE 201
Cdd:PTZ00108 81 rMTYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 202 TACKEYKHSFKQTWMNNMMKTSEAKIKHFDG-EDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNG 280
Cdd:PTZ00108 161 CVDSKSGKKFKMTWTDNMSKKSEPRITSYDGkKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGKLKVYLNG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 281 KKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIE 360
Cdd:PTZ00108 241 ERIAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 361 VVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKA 440
Cdd:PTZ00108 321 KAKKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 441 QTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHK 520
Cdd:PTZ00108 401 AAELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 521 QIMENAEINNIIKIVGLQYKKSYddaESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKH-GFLEEFITPIV 599
Cdd:PTZ00108 481 QLMNNKEIQNLFKILGLDIGKKY---EDPKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNpGFLKEFITPIV 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 600 KASK-NKQELSFYSIPEFDEWKKHIeNQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKK 678
Cdd:PTZ00108 558 KATKkGNQVISFFTIPDFEKWKQTV-GLKGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFSKKR 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 679 IDDRKEWLTNFMedrrqrrlhglPEQFLyGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRN 758
Cdd:PTZ00108 637 VEDRKEWITNYK-----------GGTYV-DHSKKKLTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFACFKRN 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 759 DKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLL 838
Cdd:PTZ00108 705 LKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKITRYI 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 839 FPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKG 918
Cdd:PTZ00108 785 FPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYRGFKG 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 919 TIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEqVLEpmlNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKL 998
Cdd:PTZ00108 865 TIERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLE---SETLKEKDVIVDYRDYSTANTVHFTVKLNDGVL 940
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 999 AQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILE 1078
Cdd:PTZ00108 941 EQWEEEGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKVRFIKH 1020
|
1050
....*....|..
gi 2462592274 1079 KIQGKITIGSRR 1090
Cdd:PTZ00108 1021 VINGELVITNAK 1032
|
|
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
50-1090 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 1583.57 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 50 SVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYdEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVS 129
Cdd:PLN03128 2 TIEETYQKKTQLEHILLRPDTYIGSTEKHTQTLWVY-EGGEMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 130 IDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKH 209
Cdd:PLN03128 81 IDVEQNTISVYNNGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETADGNRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 210 SFKQTWMNNMMKTSEAKIKHFDG-EDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAG-SCRGVKVMFNGKKLPVNG 287
Cdd:PLN03128 161 KYKQVFTNNMSVKSEPKITSCKAsENWTKITFKPDLAKFNMTRLDEDVVALMSKRVYDIAGcLGKKLKVELNGKKLPVKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 288 FRSYVDLYVKDKLDETGvaLKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNK 367
Cdd:PLN03128 241 FQDYVGLYLGPNSREDP--LPRIYEKVNDRWEVCVSLSDGSFQQVSFVNSIATIKGGTHVDYVADQIVKHIQEKVKKKNK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 368 AGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLnKK 447
Cdd:PLN03128 319 NATHVKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEEFLKKVEKCGVVENILSWAQFKQQKEL-KK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 448 CSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAE 527
Cdd:PLN03128 398 KDGAKRQRLTGIPKLDDANDAGGKKSKDCTLILTEGDSAKALAMSGLSVVGRDHYGVFPLRGKLLNVREASHKQIMKNAE 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 528 INNIIKIVGLQYKKSYDdAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK-HGFLEEFITPIVKASKNKQ 606
Cdd:PLN03128 478 ITNIKQILGLQFGKTYD-EENTKSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKiPGFLVEFITPIVKATKGGK 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 607 ELSFYSIPEFDEWKKHIENQ-KAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEW 685
Cdd:PLN03128 557 SLSFYTMPEYEAWKESLEGEtKGWTIKYYKGLGTSTSEEAKEYFSNLDIHKKEFLWQSDEDGDLIDMAFSKKRVEDRKIW 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 686 LTNFMEDrrqrrlhglpeQFLYGTATKhLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKV 765
Cdd:PLN03128 637 LNNYEPG-----------TFLDQTGNG-ISYSDFINKELILFSQADLARSIPSMVDGLKPSQRKVLFACFKRNLKSEIKV 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 766 AQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDN 845
Cdd:PLN03128 705 AQLSGYVAEHSAYHHGEASLASTIIGMAQDFVGSNNINLLTPSGQFGTRLQGGKDAASARYIFTRLSPITRALFPKDDDV 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 846 LLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQE--- 922
Cdd:PLN03128 785 LLNYLNEDGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELEPMHPWYRGFKGTITEvst 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 923 LGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEqVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAE 1002
Cdd:PLN03128 865 SRSGSYTVTGIIEQIGDTTIRITELPVRKWTQDYKE-FLEALLTGTKKKEPEIKDFKENHTDTTVHFTVTLSEEKMARAL 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 1003 AAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQG 1082
Cdd:PLN03128 944 AEGLEKKFKLSTTISTSNMHLFDKDGKIKKYDSPEDILEEFFHLRLDLYVKRKEVLLENLEYELKKLDNKARFILAVVKG 1023
|
....*...
gi 2462592274 1083 KITIGSRR 1090
Cdd:PLN03128 1024 EIVVNNRK 1031
|
|
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
27-1090 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 1428.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 27 DQNNAAKKEESETANKndsskklSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDvGMNCREVTFVPGLYKIF 106
Cdd:PLN03237 11 NSANVAAAPAASSGGK-------TIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYETD-KMVQRSVTYVPGLYKIF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 107 DEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGY 186
Cdd:PLN03237 83 DEILVNAADNKQRDPKMDSLRVVIDVEQNLISVYNNGDGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 187 GAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKI-KHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAY 265
Cdd:PLN03237 163 GAKLTNIFSTEFVIETADGKRQKKYKQVFSNNMGKKSEPVItKCKKSENWTKVTFKPDLAKFNMTHLEDDVVALMKKRVV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 266 DLAGsCRG--VKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKG 343
Cdd:PLN03237 243 DIAG-CLGktVKVELNGKRIPVKSFSDYVDLYLESANKSRPENLPRIYEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 344 GRHVDYVVDQVVGKLIEVVKKKNKAGvSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAA 423
Cdd:PLN03237 322 GTHVDYVTNQIANHVMEAVNKKNKNA-NIKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKV 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 424 SNCGIVESILNWVKFKAQTQLnKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYG 503
Cdd:PLN03237 401 MKSGIVENLLSWADFKQSKEL-KKTDGAKTTRVTGIPKLEDANEAGGKNSEKCTLILTEGDSAKALAVAGLSVVGRNYYG 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 504 VFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYddaESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWP 583
Cdd:PLN03237 480 VFPLRGKLLNVREASHKQIMNNAEIENIKQILGLQHGKQY---ESVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWP 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 584 SLLK-HGFLEEFITPIVKASK-NKQELSFYSIPEFDEWKKHIE-NQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFR 660
Cdd:PLN03237 557 SLLKvPSFLVEFITPIVKATRrGKKVLSFYSMPEYEEWKESLGgNATGWSIKYYKGLGTSTAKEGKEYFKNLGKHKKDFV 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 661 YAGPEDDAAITLAFSKKKIDDRKEWLTNFMedrrqrrlhglPEQFLYGTAtKHLTYNDFINKELILFSNSDNERSIPSLV 740
Cdd:PLN03237 637 WEDEQDGDAIELAFSKKKIEARKNWLRQYE-----------PGTHLDQTQ-KDVKYSDFVNKELILFSMADLQRSIPSMV 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 741 DGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKD 820
Cdd:PLN03237 705 DGLKPGQRKILFCSFKRNFVKEAKVAQLSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRLQGGKD 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 821 AASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRM 900
Cdd:PLN03237 785 HASARYIFTRLSPITRFLFPKDDDILLDYLNEDGQSIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPRDIVANIRRL 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 901 LDGLDPHPMLPNYKNFKGTIQE----LGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEqVLEPMLNGTDKTPA-LI 975
Cdd:PLN03237 865 LNGESMEPMHPWYRGFKGTIEKtaskEGGCTYTITGLYEEVDETTLRITELPIRRWTDDYKE-FLESLKTDNNKNKDpFI 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 976 SDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRK 1055
Cdd:PLN03237 944 KDVKAYNDDTTVHFEVILSEENMLAAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEQILEEFFHLRLEYYEKRK 1023
|
1050 1060 1070
....*....|....*....|....*....|....*
gi 2462592274 1056 EWLVGMLGAESTKLNNQARFILEKIQGKITIGSRR 1090
Cdd:PLN03237 1024 EVLLKNLEFELLKLENKVRFILAVVDGEIIVNNRK 1058
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
101-690 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 806.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 101 GLYKIFDEILVNAADNKQRDKnMTCIKVSIDPEsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT 180
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKD-NSISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 181 GGRNGYGAKLCNIFSTKFTVETACKeyKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKldKDIVALM 260
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMTT--DDDFELL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 261 TRRAYDLAGSCRGVKVMFNGKK-------LPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKG-FQQI 332
Cdd:smart00433 155 KRRLRELAFLNKGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYsENIV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 333 SFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGV-SVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFG- 410
Cdd:smart00433 235 SFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEkNIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGv 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 411 ----SKCQLSEKFFKAASNCGIVESILNWVKFKAQTQ-LNKKCSSVKYSKIKGIPKLDDANDAGGKhslECTLILTEGDS 485
Cdd:smart00433 315 ekivSECLLSFLEENPVEASKIVEKVLLAAKARAAAKkARELTRKKKLSSISLPGKLADASSAGPK---KCELFLVEGDS 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 486 AKSLAVSGLgviGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKTLRYGKIMIMTDQDQ 565
Cdd:smart00433 392 AGGSAKSGR---DRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDFD----IEKLRYGKIIIMTDADV 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 566 DGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQ--ELSFYSIPEFDEWKKHIE-NQKAWKIKYYKGLGTSTA 642
Cdd:smart00433 465 DGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPLYKVTKGKKkyVYSFYSLDEYEKWLEKTEgNKSKYEIQRYKGLGEMNA 544
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 2462592274 643 KEAKEYFADMERHRILFRYAGPEDDA-AITLAFSKKKIDDRKEWLTNFM 690
Cdd:smart00433 545 DQLWETTMDPERRTLLFVTLDDADEAdLIFSALMGDKVEPRKEWIEENA 593
|
|
| TOP4c |
smart00434 |
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC |
714-1086 |
7.11e-169 |
|
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
Pssm-ID: 214660 [Multi-domain] Cd Length: 444 Bit Score: 504.02 E-value: 7.11e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 714 LTYNDFINKELILFSNS-DNERSIPSLVDGFKPGQRKVLFTCFKRNDKR-EVKVAQLAGSVAEMSAYH-HGEQALMMTIV 790
Cdd:smart00434 1 IDIEDFINKEYLDYSMSvINGRAIPDVRDGLKPVQRRILYAMFKRGLTPdEPKVKSARGVGDVMGKYHpHGDSSLYDTIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 791 NLAQNFVgsNNINLLQPIGQFGTRLhGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYD-DNQRVEPEWYIPIIPMV 869
Cdd:smart00434 81 RMAQDFS--NNYPLLDGQGNFGSRL-DGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNyDGQEIEPTVLPPIIPNL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 870 LINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHP----MLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEIT 945
Cdd:smart00434 158 LVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIdelmMIPWGPDFPTGGEIVGPGKYVVRGKIEIEDDNTIVIT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 946 ELPVRTWTQVYKEQVLEPMLNGtdKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFD 1025
Cdd:smart00434 238 ELPYQVNTADLIEKIAELVKDK--KIEGIIDVRDESHDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALFD 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462592274 1026 HmGCLKKYETVQdILKEFFDLRLSYYGLRKEWLVGMLGAEsTKLNNQARFILEKIQGKITI 1086
Cdd:smart00434 316 N-GRPKKYNLKE-ILKEFLDHRLEVYTRRKEYLLGKLEAE-RLHILEGLFIALSIIDEIIV 373
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
732-1080 |
3.26e-154 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 465.89 E-value: 3.26e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 732 NERSIPSLVDGFKPGQRKVLFTCFKRN---DKREVKVAQLAGSVAEMSaYHHGEQALMMTIVNLAQNFvgSNNINLLQPI 808
Cdd:cd00187 1 NGRALPDVRDGLKPVQRRILYAMFKRGltpDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 809 GQFGTRlhGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPN 887
Cdd:cd00187 78 GNFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNyDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 888 YDAREIVNNVRRMLDGLDP-------HPMLPNYKNFkGTIQ---------ELGQNQYAVSGEIFVVD---RNTVEITELP 948
Cdd:cd00187 156 HNLREVIDALRALIDNPEAsidelmeIIKGPDFPTG-GIIEgragireayETGRGRYIIRGKYEIEDdegRNTIEITELP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 949 VRTWTQVYKEQVLEPMlngTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNsMVLFDHMG 1028
Cdd:cd00187 235 YQVNKAKLKEKIAELV---KDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGIN-MVAFDPNG 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 2462592274 1029 CLKKYeTVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKI 1080
Cdd:cd00187 311 RPKKL-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNID 361
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
734-1084 |
4.22e-138 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 423.50 E-value: 4.22e-138
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 734 RSIPSLVDGFKPGQRKVLFTCFK--RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFVGsnNINLLQPIGQ 810
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 811 FGTRLHGGKDAAsPRYIFTMLSTLARLLFPAVDDNLLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYD 889
Cdd:pfam00521 77 FGSRIDGDKDAA-MRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 890 AREIVNNVRRMLDGLDP-----HPMLPNYKNFKGTIQEL--------GQNQYAVSGEIFVVDRNTVEITELPVRTWTQVY 956
Cdd:pfam00521 156 LREIIDALIALLDGPEAtllmkYIMGPDFPTGGGIIGKGgikeayktGRGKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 957 KEQVLEPMLNGTDKtpaLISDYKEYhTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHmgcLKKYETV 1036
Cdd:pfam00521 236 IEKIEELVKNGKIK---GISDIRDE-SDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDG---GPKYLGL 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 2462592274 1037 QDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLN------NQARFILEKIQGKI 1084
Cdd:pfam00521 309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGSI 362
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
98-243 |
1.74e-99 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 310.42 E-value: 1.74e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 98 FVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEK 177
Cdd:cd16930 1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462592274 178 KVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHF-DGEDYTCITFQPD 243
Cdd:cd16930 81 KVTGGRNGYGAKLCNIFSTEFTVETADSESKKKFKQTWTNNMGKASEPKITPYeKGKDYTKVTFKPD 147
|
|
| 39 |
PHA02569 |
DNA topoisomerase II large subunit; Provisional |
62-647 |
1.76e-88 |
|
DNA topoisomerase II large subunit; Provisional
Pssm-ID: 177398 [Multi-domain] Cd Length: 602 Bit Score: 297.44 E-value: 1.76e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 62 EHILLRPDTYIGSV--EPLTQFMwvydedVGmNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISI 139
Cdd:PHA02569 11 EHILKRPGMYIGSVayEAHERFL------FG-KFTQVEYVPGLVKIIDEIIDNSVDEAIRTNFKFANKIDVTIKNNQVTV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 140 WNNGKGIP---VVEHKVEKVYVPALIFGQLLTSSNYDDDEKkVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTwm 216
Cdd:PHA02569 84 SDNGRGIPqamVTTPEGEEIPGPVAAWTRTKAGSNFDDTNR-VTGGMNGVGSSLTNFFSVLFIGETCDGKNEVTVNCS-- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 217 NNM----MKTSEAKIKHfdgedyTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNgFRSYV 292
Cdd:PHA02569 161 NGAenisWSTKPGKGKG------TSVTFIPDFSHFEVNGLDQQYLDIILDRLQTLAVVFPDIKFTFNGKKVSGK-FKKYA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 293 DLYVKDKldetgvalkVIHElaNERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSv 372
Cdd:PHA02569 234 KQFGDDT---------IVQE--NDNVSIALAPSPDGFRQLSFVNGLHTKNGGHHVDCVMDDICEELIPMIKKKHKIEVT- 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 373 KPfQVKN--HIWVFINCLIeNPTFDSQTKENMTLQPKSFGSKCQLSEKFF--KAASNCGIVESILNWVKFK-------AQ 441
Cdd:PHA02569 302 KA-RVKEclTIVLFVRNMS-NPRFDSQTKERLTSPFGEIRNHIDLDYKKIakQILKTEAIIMPIIEAALARklaaekaAE 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 442 TQLNKKCSSVKYSK-IKgipklddANDAGgkHSLECTLILTEGDSAKSLAVSglgVIGRDRYGVFPLRGKILNVREASHK 520
Cdd:PHA02569 380 TKAAKKAKKAKVAKhIK-------ANLIG--KDAETTLFLTEGDSAIGYLIE---VRDEELHGGYPLRGKVLNTWGMSYA 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 521 QIMENAEINNIIKIVGLQYKksyDDAESLKtlrYGKIMIMTDQDQDG-SHIKGLLINFIhHNWPSLLKHGFLEEFITPIV 599
Cdd:PHA02569 448 DILKNKELFDICAITGLVLG---EKAENMN---YKNIAIMTDADVDGkGSIYPLLLAFF-SRWPELFEQGRIRFVKTPVI 520
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 2462592274 600 KASKNKQELSFYSIPEFDEWKkhiENQKAWKIKYYKGLGTSTAKEAKE 647
Cdd:PHA02569 521 IAQVGKETKWFYSLDEFEKAK---DSLKKWSIRYIKGLGSLRKSEYRR 565
|
|
| TopoIIA_Trans_ScTopoIIA |
cd03481 |
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
286-438 |
7.96e-87 |
|
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded by a single gene. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 239563 [Multi-domain] Cd Length: 153 Bit Score: 276.48 E-value: 7.96e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 286 NGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKK 365
Cdd:cd03481 1 KSFKDYVKLYLKDANKEDGPPPPVVYEPVNDRWEVAVALSDGQFQQVSFVNSIATTKGGTHVDYVADQIVKKLDEVVKKK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462592274 366 NKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKF 438
Cdd:cd03481 81 NKGGINVKPFQVKNHLWIFVNCLIENPSFDSQTKETLTTKPKSFGSKCELSEKFLKKAVKSGIVESVLSWAKF 153
|
|
| TOPRIM_TopoIIA |
cd03365 |
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
476-596 |
2.06e-78 |
|
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173785 [Multi-domain] Cd Length: 120 Bit Score: 252.22 E-value: 2.06e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 476 CTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaESLKTLRYG 555
Cdd:cd03365 1 CTLILTEGDSAKALAVAGLSVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILGLQHGKSDY--ESTKSLRYG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 2462592274 556 KIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKH-GFLEEFIT 596
Cdd:cd03365 79 RLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIpGFLVEFIT 120
|
|
| TOPRIM_C |
pfam16898 |
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the ... |
594-732 |
9.77e-75 |
|
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the TOPRIM domain, pfam01751 in metazoa.
Pssm-ID: 465302 [Multi-domain] Cd Length: 127 Bit Score: 242.43 E-value: 9.77e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 594 FITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLA 673
Cdd:pfam16898 1 FITPIVKVTKGKEVISFFSLPEYEEWKESTPNLKGWKIKYYKGLGTSTSEEAKEYFSNLDKHRKEFKYLGDDDDEAIDLA 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2462592274 674 FSKKKIDDRKEWLTNFMedrrqrrlhglPEQFLYgTATKHLTYNDFINKELILFSNSDN 732
Cdd:pfam16898 81 FSKKKADDRKEWLRNFN-----------PGTYLD-HSTKEISYSDFINKELILFSMADN 127
|
|
| 52 |
PHA02592 |
DNA topisomerase II medium subunit; Provisional |
718-1086 |
7.10e-71 |
|
DNA topisomerase II medium subunit; Provisional
Pssm-ID: 222896 [Multi-domain] Cd Length: 439 Bit Score: 243.43 E-value: 7.10e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 718 DFINKELILFSNSD-NERSIPSLVDGFKPGQRKVLFTC--FKRNDKREV-KVAQLAGSVAEMSaYHHGEQALMMTIVNLA 793
Cdd:PHA02592 10 SIVNNEALEYAMYTvEERAIPNLIDGLKPVQRFVIHRAleYAKGNKEKFdKVAAIAGGVADLG-YHHGETSAQDAGALMA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 794 QNFvgSNNINLLQPIGQFGTRLhgGKDAASPRYIFTMLSTLARLLFPAVDdnlLKFLYDDNQRVEPEWYIPIIPMVLING 873
Cdd:PHA02592 89 NTW--NNNIPLLDGQGNFGSRL--VQKAAAARYIFARVHDNFRKIYKDED---LAPVHEDPEHIPPAFYLPIIPMVLLNG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 874 AEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWT 953
Cdd:PHA02592 162 VSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPKVQFPEFKGEVVEIEPGSYEIRGTYELNGKTKLHITEIPVKYDR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 954 QVYKEqVLEPMLNgtdktPALISDYKEYHTDtTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLfDHMGCLKKY 1033
Cdd:PHA02592 242 ETYVA-VLDPLEE-----KGKIVSYDDCTED-GFRFKVTLKREENEEATHEKIMKDFGLIERVSQNITVI-NENGKLKVY 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 2462592274 1034 ETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITI 1086
Cdd:PHA02592 314 ENAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDLALAKAEFIKRVIAGEIVL 366
|
|
| TOPRIM_TopoIIA_like |
cd01030 |
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
476-596 |
9.63e-63 |
|
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173780 [Multi-domain] Cd Length: 115 Bit Score: 208.13 E-value: 9.63e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 476 CTLILTEGDSAKSLAVSGLGVIgrdRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYddaESLKTLRYG 555
Cdd:cd01030 1 CELILVEGDSAGGSAKQGRDRV---FQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGIGKDD---FDLDKLRYG 74
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 2462592274 556 KIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFIT 596
Cdd:cd01030 75 KIIIMTDADVDGSHIRTLLLTFFYRFWPSLLENGFLYIAQT 115
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
61-686 |
1.78e-59 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 216.12 E-value: 1.78e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 61 LEHILLRPDTYIGSvepltqfmwvYDEDvgmncrevtfvpGLYKIFDEILVNAAD-------NKqrdknmtcIKVSIDPE 133
Cdd:PRK05559 19 LEPVRKRPGMYIGS----------TDTR------------GLHHLVQEVIDNSVDealaghgKR--------IEVTLHAD 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 134 sNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA--CKEYKHSF 211
Cdd:PRK05559 69 -GSVSVRDNGRGIPVGIHPEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLHGVGVSVVNALSSRLEVEVKrdGKVYRQRF 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 212 KqtwmNNMMKTSEAKI-KHFDGEDYTCITFQPDLS-----KFKMEKLDKdivalMTRR-AYdLagsCRGVKVMFNGKKLP 284
Cdd:PRK05559 148 E----GGDPVGPLEVVgTAGKRKTGTRVRFWPDPKifdspKFSPERLKE-----RLRSkAF-L---LPGLTITLNDERER 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 285 V-----NGFRSYVDLYVKDK--LDETGVAlKVIHELANERWDVCLTLSEKGFQQI-SFVNSIATTKGGRHVDYVVDQVVG 356
Cdd:PRK05559 215 QtfhyeNGLKDYLAELNEGKetLPEEFVG-SFEGEAEGEAVEWALQWTDEGGENIeSYVNLIPTPQGGTHENGFREGLLK 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 357 KLIEVVKKKN--KAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENM-TLQPKSFGSKcQLSEKF-FKAASNCGIVESI 432
Cdd:PRK05559 294 AVREFAEKRNllPKGKKLEGEDVREGLAAVLSVKIPEPQFEGQTKEKLgSREARRFVSG-VVKDAFdLWLNQNPELAEKL 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 433 LNWVKFKAQTQLNKKCSSVKYSKIKGI---PKLddaNDAGGKHSLECTLILTEGDSAkslavSGLGVIGRDRY--GVFPL 507
Cdd:PRK05559 373 AEKAIKAAQARLRAAKKVKRKKKTSGPalpGKL---ADCTSQDPERTELFLVEGDSA-----GGSAKQARDREfqAILPL 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 508 RGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLK 587
Cdd:PRK05559 445 RGKILNTWEASLDDVLANEEIHDIIVAIGIGPGDSFD----LEDLRYGKIIIMTDADVDGAHIATLLLTFFYRHFPPLVE 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 588 HGFLeeFI--TPIVKASKNKQELSFYSIPEFDEWKKHIENQKA-WKIKYYKGLGTSTAKEAKEYFADmERHRILFRYAgP 664
Cdd:PRK05559 521 AGHV--YIalPPLYRVDKGKKKIYALDEEEKEELLKKLGKKGGkPEIQRFKGLGEMNPDQLWETTMD-PETRRLVRVT-I 596
|
650 660
....*....|....*....|....*
gi 2462592274 665 EDDAAITLAFSK---KKIDDRKEWL 686
Cdd:PRK05559 597 DDAEETEKLVDMlmgKKAEPRREWI 621
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
61-685 |
9.05e-42 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 163.28 E-value: 9.05e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 61 LEHILLRPDTYIGSVepltqfmwvyDEDvgmncrevtfvpGLYKIFDEILVNA--------ADNkqrdknmtcIKVSIDP 132
Cdd:COG0187 17 LEAVRKRPGMYIGST----------DER------------GLHHLVWEIVDNSidealagyCDR---------IEVTLHA 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 133 EsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA--CKEYKHS 210
Cdd:COG0187 66 D-GSVTVEDNGRGIPVDIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVKrdGKIYRQR 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 211 FKQTwmnnmMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVAlmtRRAYDLAGSCRGVKVMFNGKKLPV----- 285
Cdd:COG0187 145 FERG-----KPVGPLEKIGKTDRTGTTVRFKPDPEIFETTEFDYETLA---ERLRELAFLNKGLTITLTDEREEEpkeet 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 286 ----NGFRSYVDLYVKDKldeTGVALKVIH---ELANERWDVCLTLSEKGFQQI-SFVNSIATTKGGRHV---------- 347
Cdd:COG0187 217 fhyeGGIKDFVEYLNEDK---EPLHPEVIYfegEKDGIEVEVALQWNDGYSENIhSFVNNINTPEGGTHEtgfrtaltrv 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 348 --DYVVDQvvGKLievvKKKNK------------AGVSVKpfqvknhiwvfinclIENPTFDSQTKEN-MTLQPKSFGSK 412
Cdd:COG0187 294 inDYARKN--GLL----KEKDKnltgddvregltAVISVK---------------LPEPQFEGQTKTKlGNSEARGIVES 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 413 C---QLSEKFfkaASNCGIVESILNWV--------KFKAQTQLNKKCSSVKyskIKGIP-KLDDA--NDAGgkhslECTL 478
Cdd:COG0187 353 VvseKLEHYL---EENPAEAKKILEKAilaarareAARKARELVRRKSALE---SSGLPgKLADCssKDPE-----ESEL 421
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 479 ILTEGDSA----KSlavsglgviGRDRY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKTL 552
Cdd:COG0187 422 FIVEGDSAggsaKQ---------GRDREfqAILPLRGKILNVEKARLDKILKNEEIRDLITALGTGIGDDFD----LEKL 488
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 553 RYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLeeFI--TPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWK 630
Cdd:COG0187 489 RYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHV--YIaqPPLYRIKKGKKTYYAYSDAELDELLKELKGKKKVE 566
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*...
gi 2462592274 631 IKYYKGLGTSTAKEAKEYFADMErHRILFRyAGPEDDAAITLAFSK---KKIDDRKEW 685
Cdd:COG0187 567 IQRYKGLGEMNPEQLWETTMDPE-TRTLLQ-VTIEDAAEADEIFSLlmgDKVEPRREF 622
|
|
| gyrB |
PRK05644 |
DNA gyrase subunit B; Validated |
61-638 |
3.60e-38 |
|
DNA gyrase subunit B; Validated
Pssm-ID: 235542 [Multi-domain] Cd Length: 638 Bit Score: 152.56 E-value: 3.60e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 61 LEHILLRPDTYIGSVEP--LTQFMW-VYDEDVgmncrevtfvpglykifDEILVNAADNkqrdknmtcIKVSIDPEsNII 137
Cdd:PRK05644 19 LEAVRKRPGMYIGSTGErgLHHLVYeIVDNSI-----------------DEALAGYCDH---------IEVTINED-GSI 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 138 SIWNNGKGIPVVEHKVEKVyvPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA--CKEYKHSFKQ 213
Cdd:PRK05644 72 TVTDNGRGIPVDIHPKTGK--PAVevVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTWLEVEVKrdGKIYYQEYER 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 214 TwmnnmMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVAlmtRRAYDLAGSCRGVKVMF----NGKKLPV---- 285
Cdd:PRK05644 150 G-----VPVTPLEVIGETDETGTTVTFKPDPEIFETTEFDYDTLA---TRLRELAFLNKGLKITLtderEGEEKEEtfhy 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 286 -NGFRSYVDLYVKDKldetgvalKVIHE----LANERWDVCLtlsEKGFQQ--------ISFVNSIATTKGGRHV----- 347
Cdd:PRK05644 222 eGGIKEYVEYLNRNK--------EPLHEepiyFEGEKDGIEV---EVAMQYndgyseniLSFANNINTHEGGTHEegfkt 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 348 -------DYVVDQvvGKLIEvvKKKNKAG----------VSVKpfqvknhiwvfinclIENPTFDSQTK------ENMTL 404
Cdd:PRK05644 291 altrvinDYARKN--KLLKE--KDDNLTGedvregltavISVK---------------HPEPQFEGQTKtklgnsEVRGI 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 405 QPKSFGSKcqLSEkFFKaaSNCGIVESILNWVKFKAQT--------QLNKKCSSVKYSkikGIP-KLDD--ANDAGgkhs 473
Cdd:PRK05644 352 VDSVVSEA--LSE-FLE--ENPNVAKKIVEKAILAARAreaarkarELTRRKSALESS---SLPgKLADcsSKDPE---- 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 474 lECTLILTEGDSAKSLAVSGlgvigRDRY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKT 551
Cdd:PRK05644 420 -ESELYIVEGDSAGGSAKQG-----RDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGDDFD----ISK 489
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 552 LRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLeeFIT--PIVKASKNKQELsFYSIPEFDEWKKHIENQ--K 627
Cdd:PRK05644 490 LRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGYV--YIAqpPLYKIKKGGKEY-AYSDEELDEILAELKLKgnP 566
|
650
....*....|.
gi 2462592274 628 AWKIKYYKGLG 638
Cdd:PRK05644 567 KYGIQRYKGLG 577
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
287-447 |
2.16e-31 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 121.18 E-value: 2.16e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 287 GFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTL---SEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVK 363
Cdd:pfam00204 1 GLKDFVEELNKDKKPLHKEIIYFEGESPDNRIEVEVALqwtDSYSENILSFVNNIATPEGGTHVDGFKSALTRTINEYAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 364 KKN---KAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFK-AASNCGIVESILNWVKFK 439
Cdd:pfam00204 81 KKGllkKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEVKSAVEKIVSEKLEEfLEENPEIAKKILEKALQA 160
|
....*...
gi 2462592274 440 AQTQLNKK 447
Cdd:pfam00204 161 AKARLAAR 168
|
|
| TOPRIM_TopoIIA_GyrB |
cd03366 |
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
476-591 |
8.46e-27 |
|
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. DNA gyrase is more effective at relaxing supercoils than decatentating DNA. DNA gyrase in addition inserts negative supercoils in the presence of ATP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173786 [Multi-domain] Cd Length: 114 Bit Score: 105.81 E-value: 8.46e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 476 CTLILTEGDSAKSLAVSGlgvigRDRY--GVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDdaesLKTLR 553
Cdd:cd03366 1 SELYIVEGDSAGGSAKQG-----RDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGEDFD----LEKLR 71
|
90 100 110
....*....|....*....|....*....|....*...
gi 2462592274 554 YGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFL 591
Cdd:cd03366 72 YHKIIIMTDADVDGAHIRTLLLTFFFRYMRPLIENGHV 109
|
|
| PRK09631 |
PRK09631 |
DNA topoisomerase IV subunit A; Provisional |
733-1083 |
2.69e-24 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 236598 [Multi-domain] Cd Length: 635 Bit Score: 109.41 E-value: 2.69e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 733 ERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGsvaEMSAYH-HGEQALMMTIVNLAqnfvgsNNINLLQPIGQF 811
Cdd:PRK09631 22 DRAIPDVIDGLKPVQRRILHSLFEMHDGKFHKVANVVG---NTMKYHpHGDASIYEALVNLA------NKDLFIDKQGNF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 812 GTrLHGGKDAASPRYIFTMLSTLAR--LLFPAVDDNLLKFlydDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYD 889
Cdd:PRK09631 93 GN-LFTGDPASAARYIECRLTPLAKevLYNKEITEYEPSY---DGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPHN 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 890 AREIVNNVRRMLDGlDPHPMLPNYKNfkGTIQELgqNQYA-------VSGEIFVVDRNTVEITELPVRTWTQVYKEQVLE 962
Cdd:PRK09631 169 FNEILQAVKSELLG-ESFALYPDFPT--GGIVDV--SEYAdgngkvlVRAKIETKDEKTIVIREIPFGTTTESLIASIEK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 963 PMLNGTDKTPAlISDYkeyhTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHmgcLKKYETVQDILKe 1042
Cdd:PRK09631 244 AARKGKIKISS-INDY----TAENVEIEIKLPRGVYASEVIEALYAYTDCEVSISVNLLVIKDR---YPVIYTVTDIIK- 314
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 2462592274 1043 ffdlrlsyygLRKEWLVGMLGAEstkLNNQARFILEKIQGK 1083
Cdd:PRK09631 315 ----------FHAEHLQKVLKME---LELERAKLLEKIFAK 342
|
|
| gyrB |
PRK14939 |
DNA gyrase subunit B; Provisional |
61-608 |
8.91e-21 |
|
DNA gyrase subunit B; Provisional
Pssm-ID: 237860 [Multi-domain] Cd Length: 756 Bit Score: 98.63 E-value: 8.91e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 61 LEHILLRPDTYIGsvepltqfmwvyDEDVGMncrevtfvpGLYKIFDEILVNAAD-------NKqrdknmtcIKVSIDPE 133
Cdd:PRK14939 18 LDAVRKRPGMYIG------------DTDDGT---------GLHHMVYEVVDNAIDealaghcDD--------ITVTIHAD 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 134 sNIISIWNNGKGIPVVEHKVEKVyvPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKF--TVETACKEYKH 209
Cdd:PRK14939 69 -GSVSVSDNGRGIPTDIHPEEGV--SAAevIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLelTIRRDGKIHEQ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 210 SFKQTWMNNMMKTSEAKIKHfdGedyTCITFQPDLSKFKMEKLDKDIVAlmtRRAYDLAGSCRGVKVMF----NGKKLP- 284
Cdd:PRK14939 146 EFEHGVPVAPLKVVGETDKT--G---TEVRFWPSPEIFENTEFDYDILA---KRLRELAFLNSGVRIRLkderDGKEEEf 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 285 -----VNGFRSYVDlyvKDKldeTGVALKVIHeLANERWDVCLTLS---EKGFQQ--ISFVNSIATTKGGRHVD---YVV 351
Cdd:PRK14939 218 hyeggIKAFVEYLN---RNK---TPLHPNIFY-FSGEKDGIGVEVAlqwNDSYQEnvLCFTNNIPQRDGGTHLAgfrAAL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 352 DQVVGKLIEV--VKKKNK-------------AGVSVKpfqvknhiwvfinclIENPTFDSQTKENMtlqpksfGSkcqlS 416
Cdd:PRK14939 291 TRTINNYIEKegLAKKAKvsltgddaregltAVLSVK---------------VPDPKFSSQTKDKL-------VS----S 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 417 E-KffkaasncGIVESILNwvkfkaqTQL------NKKCSSVKYSKI-------------------KGIpkLDDAN---- 466
Cdd:PRK14939 345 EvR--------PAVESLVN-------EKLsefleeNPNEAKIIVGKIidaarareaarkareltrrKGA--LDIAGlpgk 407
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 467 --DAGGKHSLECTLILTEGDSA----KSlavsglgviGRDRygVF----PLRGKILNVREASHKQIMENAEINNIIKI-- 534
Cdd:PRK14939 408 laDCQEKDPALSELYLVEGDSAggsaKQ---------GRDR--KFqailPLKGKILNVEKARFDKMLSSQEIGTLITAlg 476
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462592274 535 --VGlqyKKSYDdaesLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLeeFI--TPIVKASKNKQEL 608
Cdd:PRK14939 477 cgIG---RDEFN----PDKLRYHKIIIMTDADVDGSHIRTLLLTFFYRQMPELIERGHL--YIaqPPLYKVKKGKQEQ 545
|
|
| PTZ00109 |
PTZ00109 |
DNA gyrase subunit b; Provisional |
287-589 |
8.65e-19 |
|
DNA gyrase subunit b; Provisional
Pssm-ID: 240272 [Multi-domain] Cd Length: 903 Bit Score: 92.25 E-value: 8.65e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 287 GFRSYVDLYVKDKL----DETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTkGGRHVD---YVVDQVVGKLI 359
Cdd:PTZ00109 376 GTREFLEELIKDKTplykDINIISIRGVIKNVNVEVSLSWSLESYTALIKSFANNVSTT-AGTHIDgfkYAITRCVNGNI 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 360 evvkKKNKA-GVSVKPFQ---VKNHIWVFINCLIENPTFDSQTKEnmtlqpksfgskcQLSEKFFKAasncgIVESILNW 435
Cdd:PTZ00109 455 ----KKNGYfKGNFVNIPgefIREGMTAIISVKLNGAEFDGQTKT-------------KLGNHLLKT-----ILESIVFE 512
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 436 vKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAG-----------------GKHSlECT--------LILTEGDSAkslA 490
Cdd:PTZ00109 513 -QLSEILEFEPNLLLAIYNKSLAAKKAFEEAKAAkdlirqknnqyystilpGKLV-DCIsddierneLFIVEGESA---A 587
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 491 VSGLGVIGRDRYGVFPLRGKILNVRE-ASHKQIMENAEINNIIKIVGL----QYKKSYDDAESLK--------------- 550
Cdd:PTZ00109 588 GNAKQARNREFQAVLPLKGKILNIEKiKNNKKVFENSEIKLLITSIGLsvnpVTWRQYDLSHGTKaskdesvqnnnstlt 667
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 2462592274 551 ---------TLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHG 589
Cdd:PTZ00109 668 kkknslfdtPLRYGKIILLTDADVDGEHLRILLLTLLYRFCPSLYEHG 715
|
|
| gyrA |
TIGR01063 |
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
734-1055 |
4.29e-18 |
|
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273423 [Multi-domain] Cd Length: 800 Bit Score: 90.06 E-value: 4.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 734 RSIPSLVDGFKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNINLLQPIG 809
Cdd:TIGR01063 25 RALPDVRDGLKPVHRRILYAMYElglTPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 810 QFGTRlhGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWACKLPN 887
Cdd:TIGR01063 101 NFGSI--DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVpnYDGSEQ-EPTVLPSRFPNLLVNGSSGIAVGMATNIPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 888 YDAREIVNNVRRMLDGLD----------PHPMLP-----NYKnfKGTIQ--ELGQNQYAVSGEIFV----VDRNTVEITE 946
Cdd:TIGR01063 178 HNLGEIIDALLAYIDNPDisiqelleviKGPDFPtggiiLGR--SGIRSayETGRGSIVIRARAEIeedsKGREAIIVTE 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 947 LPVrtwtQVYKEQVLEPMLN-GTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFD 1025
Cdd:TIGR01063 256 IPY----QVNKARLIEKIAElVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVSFGINMLALVK 331
|
330 340 350
....*....|....*....|....*....|....*.
gi 2462592274 1026 HmgcLKKYETVQDILKEFFDLRL------SYYGLRK 1055
Cdd:TIGR01063 332 G---LPKVLNLKELLEAFVEHRKdvitrrTIFELRK 364
|
|
| PRK09630 |
PRK09630 |
DNA topoisomerase IV subunit A; Provisional |
733-1059 |
9.01e-17 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 170022 Cd Length: 479 Bit Score: 84.56 E-value: 9.01e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 733 ERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVaeMSAYHHGEQALMMTIVNLAqnfvgsNNINLLQPIGQFG 812
Cdd:PRK09630 22 ERAIPHILDGLKPVQRRLLWTLFRMDDGKMHKVANIAGRT--MALHPHGDAPIVEALVVLA------NKGYLIDTQGNFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 813 TRLHGGKDAASpRYIFTMLSTLAR-LLFpavDDNLLKF--LYDDNQRvEPEWYIPIIPMVLINGAEGIGTGWACKLPNYD 889
Cdd:PRK09630 94 NPLTGDPHAAA-RYIEARLSPLAKeVLF---NTDLMTFhdSYDGREK-EPDILPAKLPLLLLHGVDGIAVGMTTKIFPHN 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 890 AREIVNNVRRMLDGlDPHPMLPNYknFKGTIQELGQNQ-----YAVSGEIFVVDRNTVEITELPVRTWTqvykEQVLEPM 964
Cdd:PRK09630 169 FCELLEAQIAILND-QPFTLLPDF--PSGGTMDASEYQdglgsITLRASIDIINDKTLLIKEICPSTTT----ETLIRSI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 965 LNGTDKTPALISDYKEYHTDTTvKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHmgclKKYET-VQDILKEF 1043
Cdd:PRK09630 242 ENAAKRGIIKIDSIQDFSTDLP-HIEIKLPKGIYAKDLLRPLFTHTECQVILTSRPTAIYQN----KPVETsISEILRLH 316
|
330
....*....|....*.
gi 2462592274 1044 FDLRLSYygLRKEWLV 1059
Cdd:PRK09630 317 TETLQGY--LKKELLI 330
|
|
| HATPase_GyrB-like |
cd16928 |
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ... |
102-279 |
8.32e-13 |
|
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.
Pssm-ID: 340405 [Multi-domain] Cd Length: 180 Bit Score: 67.95 E-value: 8.32e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 102 LYKIFDEILVNAAD-------NKqrdknmtcIKVSIDPEsNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDD 174
Cdd:cd16928 1 LHHLVWEIVDNSIDealagyaTE--------IEVTLHED-NSITVEDNGRGIPVDIHPKTGKSAVEVVLTVLHAGGKFDG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 175 DEKKVTGGRNGYGAKLCNIFSTKF--TVETACKEYKHSFKqtwmnNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKL 252
Cdd:cd16928 72 GSYKVSGGLHGVGVSVVNALSERLevEVKRDGKIYRQEFS-----RGGPLTPLEVIGETKKTGTTVRFWPDPEIFEKTEF 146
|
170 180
....*....|....*....|....*..
gi 2462592274 253 DKDIVAlmtRRAYDLAGSCRGVKVMFN 279
Cdd:cd16928 147 DFDTLK---RRLRELAFLNKGLKIVLE 170
|
|
| PRK05561 |
PRK05561 |
DNA topoisomerase 4 subunit A; |
733-908 |
1.76e-11 |
|
DNA topoisomerase 4 subunit A;
Pssm-ID: 235503 [Multi-domain] Cd Length: 742 Bit Score: 68.60 E-value: 1.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 733 ERSIPSLVDGFKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNINLLQPI 808
Cdd:PRK05561 33 DRALPDVRDGLKPVQRRILYAMSElglTPDAKFKKSARVVGDV--LGKYHpHGDSSIYDAMVRMAQDF--SYRYPLVDGQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 809 GQFGTRlhGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWACKLP 886
Cdd:PRK05561 109 GNFGSI--DGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVpnFDGTLK-EPTVLPARFPNLLLNGATGIAVGMATDIP 185
|
170 180
....*....|....*....|..
gi 2462592274 887 NYDAREIVNNVRRMLDgldpHP 908
Cdd:PRK05561 186 PHNLREVIDAAIHLID----NP 203
|
|
| PRK12758 |
PRK12758 |
DNA gyrase/topoisomerase IV subunit A; |
733-970 |
6.22e-11 |
|
DNA gyrase/topoisomerase IV subunit A;
Pssm-ID: 237192 [Multi-domain] Cd Length: 869 Bit Score: 66.95 E-value: 6.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 733 ERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVaeMsAYH-HGEQALMMTIVNLAQNFVgsnninLLQPIGQF 811
Cdd:PRK12758 41 ERAVPHIEDGLKPVQRRILHSMKEMDDGRYNKVANVVGHT--M-QYHpHGDASIGDALVQLGQKDL------LIDTQGNW 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 812 GTRLhGGKDAASPRYIFTMLSTLA-RLLF-PAVDDNLLKFlydDNQRVEPEwYIPI-IPMVLINGAEGIGTGWACKLPNY 888
Cdd:PRK12758 112 GNIL-TGDGAAAPRYIEARLSKFAlEVVFnPKTTEWQLSY---DGRKKEPV-TLPVkFPLLLAQGAEGIAVGLSTKILPH 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 889 DAREIVNNVRRMLDGlDPHPMLPNYKNfKGTIQELGQNQYAVSGEIFV------VDRNTVEITELPVRTWTqvykEQVLE 962
Cdd:PRK12758 187 NFNELIDASIAYLKG-KEFKLYPDFPT-GGIIDVSNYNDGERGGRVRVrakiekLDKKTLVITEIPYGTTT----SSLID 260
|
....*...
gi 2462592274 963 PMLNGTDK 970
Cdd:PRK12758 261 SILKANDK 268
|
|
| PRK05560 |
PRK05560 |
DNA gyrase subunit A; Validated |
734-902 |
9.66e-10 |
|
DNA gyrase subunit A; Validated
Pssm-ID: 235502 [Multi-domain] Cd Length: 805 Bit Score: 62.74 E-value: 9.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 734 RSIPSLVDGFKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgsnniNLLQPI- 808
Cdd:PRK05560 29 RALPDVRDGLKPVHRRILYAMNElgnTPDKPYKKSARIVGDV--MGKYHpHGDSAVYDALVRMAQDF------SMRYPLv 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 809 -GQ--FGTRlhGGKDAASPRYiftmlsTLARLLFPA-----------VD--DNllkflYDDNQRvEPEwYIPI-IPMVLI 871
Cdd:PRK05560 101 dGQgnFGSI--DGDPAAAMRY------TEARMSKIAhelladidketVDfvPN-----YDGSEQ-EPT-VLPArFPNLLV 165
|
170 180 190
....*....|....*....|....*....|.
gi 2462592274 872 NGAEGIGTGWACKLPNYDAREIVNNVRRMLD 902
Cdd:PRK05560 166 NGSSGIAVGMATNIPPHNLGEVIDACLALID 196
|
|
| TopoII_MutL_Trans |
cd00329 |
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
288-400 |
1.14e-09 |
|
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families.
Pssm-ID: 238202 [Multi-domain] Cd Length: 107 Bit Score: 56.89 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 288 FRSYVDLYVKDKldetgVALKVIH---ELANERWDVCLTLSE----KGFQQISFVNSIATTKGGRHVDYVVDQVVGKLie 360
Cdd:cd00329 1 LKDRLAEILGDK-----VADKLIYvegESDGFRVEGAISYPDsgrsSKDRQFSFVNGRPVREGGTHVKAVREAYTRAL-- 73
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 2462592274 361 vvkkknkagvsvKPFQVKNHIWVFINCLIENPTFD---SQTKE 400
Cdd:cd00329 74 ------------NGDDVRRYPVAVLSLKIPPSLVDvnvHPTKE 104
|
|
| GyrA |
COG0188 |
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair]; |
734-902 |
4.43e-09 |
|
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
Pssm-ID: 439958 [Multi-domain] Cd Length: 804 Bit Score: 60.83 E-value: 4.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 734 RSIPSLVDGFKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNINLLQPIG 809
Cdd:COG0188 34 RALPDVRDGLKPVHRRILYAMHElglTPDKPYKKSARVVGDV--MGKYHpHGDSAVYDALVRMAQDF--SMRYPLVDGQG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 810 QFGTRlhGGKDAASPRYiftmlsTLARLLFPA-----------VD--DNllkflYDDNQRvEPEwYIP-IIPMVLINGAE 875
Cdd:COG0188 110 NFGSI--DGDPAAAMRY------TEARLAKIAeelladidkdtVDfvPN-----YDGSEQ-EPT-VLPaRFPNLLVNGSS 174
|
170 180
....*....|....*....|....*..
gi 2462592274 876 GIGTGWACKLPNYDAREIVNNVRRMLD 902
Cdd:COG0188 175 GIAVGMATNIPPHNLGEVIDACIALID 201
|
|
| PRK13979 |
PRK13979 |
DNA topoisomerase IV subunit A; Provisional |
733-902 |
8.22e-09 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 237576 [Multi-domain] Cd Length: 957 Bit Score: 59.73 E-value: 8.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 733 ERSIPSLVDGFKPGQRKVLFTCFKRN---DKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNINLLQPI 808
Cdd:PRK13979 36 DRALPDVRDGLKPVHRRILYGAYMLKafpDKPYYKSARIVGDI--LGKYHpHGDSSVYDAMVILAQDF--TTRMPLIDGH 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 809 GQFGTRlhGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFL--YDDNQRvEPEWYIPIIPMVLINGAEGIGTGWACKLP 886
Cdd:PRK13979 112 GNWGSI--DGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVdnYSDSEK-EPEVLPARYPNLLVNGAFGIAVGLATNIP 188
|
170
....*....|....*.
gi 2462592274 887 NYDAREIVNNVRRMLD 902
Cdd:PRK13979 189 PHNLKEVIDGTLAYID 204
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
101-198 |
9.76e-07 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 48.52 E-value: 9.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 101 GLYKIFDEILVNAADNKQrdkNMTCIKVSIDPESNI-ISIWNNGKGIPVVEHKvekvyvpaLIFGQLLTSSnydddekKV 179
Cdd:pfam02518 5 RLRQVLSNLLDNALKHAA---KAGEITVTLSEGGELtLTVEDNGIGIPPEDLP--------RIFEPFSTAD-------KR 66
|
90
....*....|....*....
gi 2462592274 180 TGGRNGYGAKLCNIFSTKF 198
Cdd:pfam02518 67 GGGGTGLGLSIVRKLVELL 85
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
101-201 |
2.49e-06 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 47.26 E-value: 2.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 101 GLYKIFDEILVNAADNKQRDKNMTcIKVSIDPESNIISIWNNGKGIPvvEHKVEKVYVPaliFGQLltssnyddDEKKVT 180
Cdd:smart00387 5 RLRQVLSNLLDNAIKYTPEGGRIT-VTLERDGDHVEITVEDNGPGIP--PEDLEKIFEP---FFRT--------DKRSRK 70
|
90 100
....*....|....*....|.
gi 2462592274 181 GGRNGYGAKLCNIFSTKFTVE 201
Cdd:smart00387 71 IGGTGLGLSIVKKLVELHGGE 91
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
477-577 |
2.76e-06 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 46.58 E-value: 2.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 477 TLILTEGDS-AKSLAvsglGVIGRDRYGVFPLRGKILNVREASHKQIMenaeinNIIKIVGLQYKKsyddaeslktlryg 555
Cdd:pfam01751 1 ELIIVEGPSdAIALE----KALGGGFQAVVAVLGHLLSLEKGPKKKAL------KALKELALKAKE-------------- 56
|
90 100
....*....|....*....|..
gi 2462592274 556 kIMIMTDQDQDGSHIKGLLINF 577
Cdd:pfam01751 57 -VILATDPDREGEAIALKLLEL 77
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
476-578 |
1.17e-03 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 38.95 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462592274 476 CTLILTEGDS-AKSLAVsglgvIGRDRYGVFPLRGKILNvreashkqimenAEINNIIKIVGlqykksyddaeslktlRY 554
Cdd:cd00188 1 KKLIIVEGPSdALALAQ-----AGGYGGAVVALGGHALN------------KTRELLKRLLG----------------EA 47
|
90 100
....*....|....*....|....
gi 2462592274 555 GKIMIMTDQDQDGSHIKGLLINFI 578
Cdd:cd00188 48 KEVIIATDADREGEAIALRLLELL 71
|
|
| |
