NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462594117|ref|XP_054204560|]
View 

26S proteasome non-ATPase regulatory subunit 6 isoform X1 [Homo sapiens]

Protein Classification

COP9 signalosome complex subunit 1; PCI domain-containing protein( domain architecture ID 10566212)

The COP9 signalosome subunit 1 (CSN1) is an essential component of the CSN complex and is involved in the deubiquitination of target proteins which helps to regulate the stability and activity of a variety of proteins involved in different cellular pathways; PCI domain-containing protein such as 26S proteasome regulatory subunit RPN9, a non-ATPase subunit of the proteasome that play a role in the recognition and unfolding of ubiquitinated substrates and the delivery of these substrates to the proteolytic core of the proteasome for degradation.

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
 119-292 1.64e-86

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


:

Pssm-ID: 431387  Cd Length: 174  Bit Score: 257.89  E-value: 1.64e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594117 119 DVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLL 198
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594117 199 RIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVY 278
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGDWERRNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTSTELISYEDVAVYGVL 160

                         170
                  ....*....|....
gi 2462594117 279 VSMIALERPDLREK 292
Cdd:pfam10602 161 CALASLDRVDLKAK 174
 
Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
 119-292 1.64e-86

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


Pssm-ID: 431387  Cd Length: 174  Bit Score: 257.89  E-value: 1.64e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594117 119 DVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLL 198
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594117 199 RIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVY 278
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGDWERRNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTSTELISYEDVAVYGVL 160

                         170
                  ....*....|....
gi 2462594117 279 VSMIALERPDLREK 292
Cdd:pfam10602 161 CALASLDRVDLKAK 174
RPN7 COG5187
26S proteasome regulatory complex component, contains PCI domain [Posttranslational ...
 103-328 7.43e-64

26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227514 [Multi-domain]  Cd Length: 412  Bit Score: 208.23  E-value: 7.43e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594117 103 MAPYYEALC-----KSLDWQIDVD--LLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGALT 175
Cdd:COG5187    57 MAPLYKYLAekgnpKTSASVIKFDrgRMNTLLKKNEEKIEELDERIREKEEDNGETEGSEADRNIAEYYCQIMDIQNGFE 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594117 176 AFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFL 255
Cdd:COG5187   137 WMRRLMRDAMSTGLKIDVFLCKIRLGLIYGDRKVVEESLEVADDIIEKGGDWERRNRYKVYKGIFKMMRRNFKEAAILLS 216

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462594117 256 DTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVL---HSLPAVRQYLFSLYECRYSVFFQSL 328
Cdd:COG5187   217 DILPTFESSELISYSRAVRYAIFCGLLRLERRDIKTKILDSPEVLDVIgssEKLGSLVQLATSLYECDYGGDFMNL 292
 
Name Accession Description Interval E-value
RPN7 pfam10602
26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher ...
 119-292 1.64e-86

26S proteasome subunit RPN7; RPN7 (known as the non ATPase regulatory subunit 6 in higher eukaryotes) is one of the lid subunits of the 26S proteasome and has been shown in Saccharomyces cerevisiae to be required for structural integrity. The 26S proteasome is is involved in the ATP-dependent degradation of ubiquitinated proteins.


Pssm-ID: 431387  Cd Length: 174  Bit Score: 257.89  E-value: 1.64e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594117 119 DVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLL 198
Cdd:pfam10602   1 DEAWVEELKKKNEKELEELDAELKDAKENLGKEEIRMANLDLAEHYAKIGDLENALKAYERAREYCTSLGHKIDMCLNLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594117 199 RIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFLDTVSTFTSYELMDYKTFVTYTVY 278
Cdd:pfam10602  81 RVGIFFNDWDLVSKYIEKAKSLIEKGGDWERRNRLKVYEGLALLAIRDFKEAAKLFLDSLSTFTSTELISYEDVAVYGVL 160

                         170
                  ....*....|....
gi 2462594117 279 VSMIALERPDLREK 292
Cdd:pfam10602 161 CALASLDRVDLKAK 174
RPN7 COG5187
26S proteasome regulatory complex component, contains PCI domain [Posttranslational ...
 103-328 7.43e-64

26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227514 [Multi-domain]  Cd Length: 412  Bit Score: 208.23  E-value: 7.43e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594117 103 MAPYYEALC-----KSLDWQIDVD--LLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGALT 175
Cdd:COG5187    57 MAPLYKYLAekgnpKTSASVIKFDrgRMNTLLKKNEEKIEELDERIREKEEDNGETEGSEADRNIAEYYCQIMDIQNGFE 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462594117 176 AFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGDWDRRNRLKVYQGLYCVAIRDFKQAAELFL 255
Cdd:COG5187   137 WMRRLMRDAMSTGLKIDVFLCKIRLGLIYGDRKVVEESLEVADDIIEKGGDWERRNRYKVYKGIFKMMRRNFKEAAILLS 216

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462594117 256 DTVSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVL---HSLPAVRQYLFSLYECRYSVFFQSL 328
Cdd:COG5187   217 DILPTFESSELISYSRAVRYAIFCGLLRLERRDIKTKILDSPEVLDVIgssEKLGSLVQLATSLYECDYGGDFMNL 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH