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Conserved domains on  [gi|2462599321|ref|XP_054207020|]
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endosomal/lysosomal proton channel TMEM175 isoform X4 [Homo sapiens]

Protein Classification

TMEM175 family protein( domain architecture ID 10535616)

transmembrane protein 175 (TMEM175) family protein is a DUF1211 domain-containing protein; similar to vertebrate transmembrane protein 175 (TMEM175), an organelle-specific potassium channel responsible for potassium conductance in endosomes and lysosomes

Gene Ontology:  GO:0022841|GO:0071805
PubMed:  26317472

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM175 pfam06736
Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of ...
 150-246 8.91e-25

Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of transmembrane protein 175 which is an organelle-specific potassium channel responsible for potassium conductance in endosomes and lysosomes. It forms a potassium-permeable leak-like channel, which regulates luminal pH stability and is required for autophagosome-lysosome fusion. TMEM175 is the major lysosomal potassium conductance. It is present in eukaryotes, where TMEM175 has two repeats of 6-transmembrane-spanning segments, and also in prokaryotes in which it has one copy.


:

Pssm-ID: 429088  Cd Length: 88  Bit Score: 96.83  E-value: 8.91e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599321 150 RVEAFSDGVYAIVATLLILDIcedNVPDPKDvkerfsGSLVAALSATGPRFLAYFGSFATVGLLWFAHHSLFLHVRKATR 229
Cdd:pfam06736   1 RLEAFSDGVFAIAITLLVLEI---KVPDGAD------GELLAALLELWPSFLAYLLSFLVVGIFWINHHRLFRRIKKVDG 71

                          90
                  ....*....|....*..
gi 2462599321 230 AMGLLNTLSLAFVGGLP 246
Cdd:pfam06736  72 RLLWLNLLLLFFISLLP 88
TMEM175 pfam06736
Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of ...
 1-42 1.19e-08

Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of transmembrane protein 175 which is an organelle-specific potassium channel responsible for potassium conductance in endosomes and lysosomes. It forms a potassium-permeable leak-like channel, which regulates luminal pH stability and is required for autophagosome-lysosome fusion. TMEM175 is the major lysosomal potassium conductance. It is present in eukaryotes, where TMEM175 has two repeats of 6-transmembrane-spanning segments, and also in prokaryotes in which it has one copy.


:

Pssm-ID: 429088  Cd Length: 88  Bit Score: 51.76  E-value: 1.19e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462599321   1 MTFLIVTVAWAAHTRLFQVVGKTDDTLALLNLACMMTITFLP 42
Cdd:pfam06736  47 LSFLVVGIFWINHHRLFRRIKKVDGRLLWLNLLLLFFISLLP 88
 
Name Accession Description Interval E-value
TMEM175 pfam06736
Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of ...
 150-246 8.91e-25

Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of transmembrane protein 175 which is an organelle-specific potassium channel responsible for potassium conductance in endosomes and lysosomes. It forms a potassium-permeable leak-like channel, which regulates luminal pH stability and is required for autophagosome-lysosome fusion. TMEM175 is the major lysosomal potassium conductance. It is present in eukaryotes, where TMEM175 has two repeats of 6-transmembrane-spanning segments, and also in prokaryotes in which it has one copy.


Pssm-ID: 429088  Cd Length: 88  Bit Score: 96.83  E-value: 8.91e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599321 150 RVEAFSDGVYAIVATLLILDIcedNVPDPKDvkerfsGSLVAALSATGPRFLAYFGSFATVGLLWFAHHSLFLHVRKATR 229
Cdd:pfam06736   1 RLEAFSDGVFAIAITLLVLEI---KVPDGAD------GELLAALLELWPSFLAYLLSFLVVGIFWINHHRLFRRIKKVDG 71

                          90
                  ....*....|....*..
gi 2462599321 230 AMGLLNTLSLAFVGGLP 246
Cdd:pfam06736  72 RLLWLNLLLLFFISLLP 88
COG3548 COG3548
Uncharacterized membrane protein [Function unknown];
141-326 3.19e-23

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 442769  Cd Length: 203  Bit Score: 96.14  E-value: 3.19e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599321 141 DLHEPLSKERVEAFSDGVYAIVATLLILDIcedNVPDPKDvkerfsGSLVAALSATGPRFLAYFGSFATVGLLWFAHHSL 220
Cdd:COG3548     5 DEEAERGKERLEAFSDGVFAIAITLLVLEL---KVPEGSD------GELLAALLELWPSFLSYVLSFIVIGIYWNNHHRL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599321 221 FLHVRKATRAMGLLNTLSLAFVGGLPLAyqqTSAFARQPRDELeRVRVSCTIIFLASIFQLAMWTTALLHQ--AETLQPS 298
Cdd:COG3548    76 FRYVKRVDGRLLWLNLLLLFFISLLPFT---TALLGEYPFAPL-AVALYGLNLLLIGLAYLLLWRYAIRHGllDSGLAKA 151

                         170       180
                  ....*....|....*....|....*...
gi 2462599321 299 VWFGGREHVLMFakLALYPCASLLAFAS 326
Cdd:COG3548   152 LIRGIDRKGLIS--PLLYLLAIVLAFFS 177
TMEM175 pfam06736
Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of ...
 1-42 1.19e-08

Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of transmembrane protein 175 which is an organelle-specific potassium channel responsible for potassium conductance in endosomes and lysosomes. It forms a potassium-permeable leak-like channel, which regulates luminal pH stability and is required for autophagosome-lysosome fusion. TMEM175 is the major lysosomal potassium conductance. It is present in eukaryotes, where TMEM175 has two repeats of 6-transmembrane-spanning segments, and also in prokaryotes in which it has one copy.


Pssm-ID: 429088  Cd Length: 88  Bit Score: 51.76  E-value: 1.19e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462599321   1 MTFLIVTVAWAAHTRLFQVVGKTDDTLALLNLACMMTITFLP 42
Cdd:pfam06736  47 LSFLVVGIFWINHHRLFRRIKKVDGRLLWLNLLLLFFISLLP 88
 
Name Accession Description Interval E-value
TMEM175 pfam06736
Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of ...
 150-246 8.91e-25

Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of transmembrane protein 175 which is an organelle-specific potassium channel responsible for potassium conductance in endosomes and lysosomes. It forms a potassium-permeable leak-like channel, which regulates luminal pH stability and is required for autophagosome-lysosome fusion. TMEM175 is the major lysosomal potassium conductance. It is present in eukaryotes, where TMEM175 has two repeats of 6-transmembrane-spanning segments, and also in prokaryotes in which it has one copy.


Pssm-ID: 429088  Cd Length: 88  Bit Score: 96.83  E-value: 8.91e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599321 150 RVEAFSDGVYAIVATLLILDIcedNVPDPKDvkerfsGSLVAALSATGPRFLAYFGSFATVGLLWFAHHSLFLHVRKATR 229
Cdd:pfam06736   1 RLEAFSDGVFAIAITLLVLEI---KVPDGAD------GELLAALLELWPSFLAYLLSFLVVGIFWINHHRLFRRIKKVDG 71

                          90
                  ....*....|....*..
gi 2462599321 230 AMGLLNTLSLAFVGGLP 246
Cdd:pfam06736  72 RLLWLNLLLLFFISLLP 88
COG3548 COG3548
Uncharacterized membrane protein [Function unknown];
141-326 3.19e-23

Uncharacterized membrane protein [Function unknown];


Pssm-ID: 442769  Cd Length: 203  Bit Score: 96.14  E-value: 3.19e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599321 141 DLHEPLSKERVEAFSDGVYAIVATLLILDIcedNVPDPKDvkerfsGSLVAALSATGPRFLAYFGSFATVGLLWFAHHSL 220
Cdd:COG3548     5 DEEAERGKERLEAFSDGVFAIAITLLVLEL---KVPEGSD------GELLAALLELWPSFLSYVLSFIVIGIYWNNHHRL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599321 221 FLHVRKATRAMGLLNTLSLAFVGGLPLAyqqTSAFARQPRDELeRVRVSCTIIFLASIFQLAMWTTALLHQ--AETLQPS 298
Cdd:COG3548    76 FRYVKRVDGRLLWLNLLLLFFISLLPFT---TALLGEYPFAPL-AVALYGLNLLLIGLAYLLLWRYAIRHGllDSGLAKA 151

                         170       180
                  ....*....|....*....|....*...
gi 2462599321 299 VWFGGREHVLMFakLALYPCASLLAFAS 326
Cdd:COG3548   152 LIRGIDRKGLIS--PLLYLLAIVLAFFS 177
TMEM175 pfam06736
Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of ...
 1-42 1.19e-08

Endosomal/lysosomal potassium channel TMEM175; This family represents the conserved region of transmembrane protein 175 which is an organelle-specific potassium channel responsible for potassium conductance in endosomes and lysosomes. It forms a potassium-permeable leak-like channel, which regulates luminal pH stability and is required for autophagosome-lysosome fusion. TMEM175 is the major lysosomal potassium conductance. It is present in eukaryotes, where TMEM175 has two repeats of 6-transmembrane-spanning segments, and also in prokaryotes in which it has one copy.


Pssm-ID: 429088  Cd Length: 88  Bit Score: 51.76  E-value: 1.19e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2462599321   1 MTFLIVTVAWAAHTRLFQVVGKTDDTLALLNLACMMTITFLP 42
Cdd:pfam06736  47 LSFLVVGIFWINHHRLFRRIKKVDGRLLWLNLLLLFFISLLP 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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