NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2462599636|ref|XP_054207175|]
View 

LIM domain-binding protein 2 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LIM_bind pfam01803
LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 ...
 81-270 7.08e-29

LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. The Drosophila protein Chip is required for segmentation and activity of a remote wing margin enhancer. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions.


:

Pssm-ID: 426444  Cd Length: 242  Bit Score: 112.75  E-value: 7.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599636  81 NNDSDNLWWDAFATEFFEDDATLTLSFCL----EDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKE-SYHNSSIT 155
Cdd:pfam01803  14 KNLNDIEYWQKFVAEFFSPTGVLRHSLKSydcgGKEPKQFEITTPALPRYFVTLFDSGVKRIQLILDGAREqVLSNGSIF 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599636 156 VDCDQCTMVT--QHGkpmfTKVCTEGRLILEFTFDDlmRIKTWHFTIRQYRELVPRSILAMHA----------------- 216
Cdd:pfam01803  94 VECPKASFTYwyEDG----SQVVLTGQLRALFDADL--KIEWLEFCTRSHEEYIPRNSLEKLLkqlhewadlsqspkmsk 167

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462599636 217 -------------------QDPQVLDQL-SKNITRMGLTNFTLNYLRLCVILEPMQELMS-RHKTYNLSPRDCLK 270
Cdd:pfam01803 168 kvlqkqqifqalsskspapEPPEAIKELpSSFVNDFGIPEAVMRFLQIGEVMSSMKDLMEfSKQNNILSPLEALE 242
LID pfam17916
LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that ...
 334-362 6.14e-09

LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that are critical in the development of many cell types and tissues. The activity of LIM-HD proteins is dependent on the essential cofactor LIM domain-binding protein 1 (Ldb1). This entry represents a 30-residue LIM interaction domain (LID) that binds to the LIM domains of all LIM-HD and closely related LIM-only (LMO) proteins. Isl1 (Insulin gene enhancer protein 1) and Isl2 each contain a LID-like sequence in their C-terminal regions, the Lhx3-binding domain (LBD), which binds the LIM domains Lhx3 and Lhx4.


:

Pssm-ID: 465564  Cd Length: 29  Bit Score: 51.32  E-value: 6.14e-09
                          10        20
                  ....*....|....*....|....*....
gi 2462599636 334 DVMVVGEPTLMGGEFGDEDERLITRLENT 362
Cdd:pfam17916   1 DVMVVGEPSMMGSDFGEGDERTISRVENT 29
 
Name Accession Description Interval E-value
LIM_bind pfam01803
LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 ...
 81-270 7.08e-29

LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. The Drosophila protein Chip is required for segmentation and activity of a remote wing margin enhancer. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions.


Pssm-ID: 426444  Cd Length: 242  Bit Score: 112.75  E-value: 7.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599636  81 NNDSDNLWWDAFATEFFEDDATLTLSFCL----EDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKE-SYHNSSIT 155
Cdd:pfam01803  14 KNLNDIEYWQKFVAEFFSPTGVLRHSLKSydcgGKEPKQFEITTPALPRYFVTLFDSGVKRIQLILDGAREqVLSNGSIF 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599636 156 VDCDQCTMVT--QHGkpmfTKVCTEGRLILEFTFDDlmRIKTWHFTIRQYRELVPRSILAMHA----------------- 216
Cdd:pfam01803  94 VECPKASFTYwyEDG----SQVVLTGQLRALFDADL--KIEWLEFCTRSHEEYIPRNSLEKLLkqlhewadlsqspkmsk 167

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462599636 217 -------------------QDPQVLDQL-SKNITRMGLTNFTLNYLRLCVILEPMQELMS-RHKTYNLSPRDCLK 270
Cdd:pfam01803 168 kvlqkqqifqalsskspapEPPEAIKELpSSFVNDFGIPEAVMRFLQIGEVMSSMKDLMEfSKQNNILSPLEALE 242
LID pfam17916
LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that ...
 334-362 6.14e-09

LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that are critical in the development of many cell types and tissues. The activity of LIM-HD proteins is dependent on the essential cofactor LIM domain-binding protein 1 (Ldb1). This entry represents a 30-residue LIM interaction domain (LID) that binds to the LIM domains of all LIM-HD and closely related LIM-only (LMO) proteins. Isl1 (Insulin gene enhancer protein 1) and Isl2 each contain a LID-like sequence in their C-terminal regions, the Lhx3-binding domain (LBD), which binds the LIM domains Lhx3 and Lhx4.


Pssm-ID: 465564  Cd Length: 29  Bit Score: 51.32  E-value: 6.14e-09
                          10        20
                  ....*....|....*....|....*....
gi 2462599636 334 DVMVVGEPTLMGGEFGDEDERLITRLENT 362
Cdd:pfam17916   1 DVMVVGEPSMMGSDFGEGDERTISRVENT 29
 
Name Accession Description Interval E-value
LIM_bind pfam01803
LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 ...
 81-270 7.08e-29

LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. The Drosophila protein Chip is required for segmentation and activity of a remote wing margin enhancer. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions.


Pssm-ID: 426444  Cd Length: 242  Bit Score: 112.75  E-value: 7.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599636  81 NNDSDNLWWDAFATEFFEDDATLTLSFCL----EDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKE-SYHNSSIT 155
Cdd:pfam01803  14 KNLNDIEYWQKFVAEFFSPTGVLRHSLKSydcgGKEPKQFEITTPALPRYFVTLFDSGVKRIQLILDGAREqVLSNGSIF 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599636 156 VDCDQCTMVT--QHGkpmfTKVCTEGRLILEFTFDDlmRIKTWHFTIRQYRELVPRSILAMHA----------------- 216
Cdd:pfam01803  94 VECPKASFTYwyEDG----SQVVLTGQLRALFDADL--KIEWLEFCTRSHEEYIPRNSLEKLLkqlhewadlsqspkmsk 167

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462599636 217 -------------------QDPQVLDQL-SKNITRMGLTNFTLNYLRLCVILEPMQELMS-RHKTYNLSPRDCLK 270
Cdd:pfam01803 168 kvlqkqqifqalsskspapEPPEAIKELpSSFVNDFGIPEAVMRFLQIGEVMSSMKDLMEfSKQNNILSPLEALE 242
LID pfam17916
LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that ...
 334-362 6.14e-09

LIM interaction domain (LID); LIM-homeodomain (LIM-HD) proteins are transcription factors that are critical in the development of many cell types and tissues. The activity of LIM-HD proteins is dependent on the essential cofactor LIM domain-binding protein 1 (Ldb1). This entry represents a 30-residue LIM interaction domain (LID) that binds to the LIM domains of all LIM-HD and closely related LIM-only (LMO) proteins. Isl1 (Insulin gene enhancer protein 1) and Isl2 each contain a LID-like sequence in their C-terminal regions, the Lhx3-binding domain (LBD), which binds the LIM domains Lhx3 and Lhx4.


Pssm-ID: 465564  Cd Length: 29  Bit Score: 51.32  E-value: 6.14e-09
                          10        20
                  ....*....|....*....|....*....
gi 2462599636 334 DVMVVGEPTLMGGEFGDEDERLITRLENT 362
Cdd:pfam17916   1 DVMVVGEPSMMGSDFGEGDERTISRVENT 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH