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Conserved domains on  [gi|2462599750|ref|XP_054207227|]
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bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 isoform X1 [Homo sapiens]

Protein Classification

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase( domain architecture ID 10572471)

bifunctional heparan sulfate N-deacetylase/N-sulfotransferase catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 76-506 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


:

Pssm-ID: 463450  Cd Length: 429  Bit Score: 868.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750  76 TDPTVLVFVESQYSSLGQDIIMILESSRFQYHIEIApgKGDLPVLIDKMKGKYILIIYENILKYINMDSWNRSLLDKYCV 155
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIA--KKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 156 EYGVGVIGFHKTSEKSVQSFQLKGFPFSIYGNLAVKDCCINPHSPLIRVTKSSKLEKGSLPGTDWTVFQINHSAYQPVIF 235
Cdd:pfam12062  79 EYGVGIIGFFKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 236 AKVKTPENLSPSISKGAFYATIIHDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVG 315
Cdd:pfam12062 159 AKVKSGEESPSPGLDAALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFVG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 316 KEGTRMNTNDVKALLDTQNLLRAQITNFTFNLGFSGKFYHTGTEEEDEGDDCLLGSVDEFWWFPHMWSHMQPHLFHNESS 395
Cdd:pfam12062 239 KEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFHNQTV 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 396 LVEQMILNKKFALEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKKVWNIKITSTEEYPHLKPARYRRGFIHKNIMVLPRQ 475
Cdd:pfam12062 319 LEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPRQ 398

                         410       420       430
                  ....*....|....*....|....*....|.
gi 2462599750 476 TCGLFTHTIFYKEYPGGPKELDKSIQGGELF 506
Cdd:pfam12062 399 TCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
595-824 9.53e-38

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 142.10  E-value: 9.53e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 595 LPKFLVIGPQKTGTTALYLFLVMHPSILSNSPSpktfEEVQFFNRNNYHRGIDWYMDFFPVPSNVTTDFLFEKSANYF-- 672
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKS----EEPHLFNNHNRSPFLEWYPGDTYFDVAEGPVRLNALPSPRIik 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 673 -HSEEAPKRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALKFSFYEVisagprapselRALQKRCLVPGWYASH 751
Cdd:pfam00685  77 tHLPLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV-----------EDFLNGKVNCGSYFDH 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 752 IERWLVYFPPFQLLIIDGQQLRTDPATVMDEVQKFLGVLPHY----NYSEALTFDSHKGFWCQLL-------EEGKTKCL 820
Cdd:pfam00685 146 VKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEeeldKIVKHLSFENMKGNPCLNYsklpkevSPFFRKGL 225


                  ....
gi 2462599750 821 GKSK 824
Cdd:pfam00685 226 VGDW 229
 
Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 76-506 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


Pssm-ID: 463450  Cd Length: 429  Bit Score: 868.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750  76 TDPTVLVFVESQYSSLGQDIIMILESSRFQYHIEIApgKGDLPVLIDKMKGKYILIIYENILKYINMDSWNRSLLDKYCV 155
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIA--KKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 156 EYGVGVIGFHKTSEKSVQSFQLKGFPFSIYGNLAVKDCCINPHSPLIRVTKSSKLEKGSLPGTDWTVFQINHSAYQPVIF 235
Cdd:pfam12062  79 EYGVGIIGFFKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 236 AKVKTPENLSPSISKGAFYATIIHDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVG 315
Cdd:pfam12062 159 AKVKSGEESPSPGLDAALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFVG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 316 KEGTRMNTNDVKALLDTQNLLRAQITNFTFNLGFSGKFYHTGTEEEDEGDDCLLGSVDEFWWFPHMWSHMQPHLFHNESS 395
Cdd:pfam12062 239 KEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFHNQTV 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 396 LVEQMILNKKFALEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKKVWNIKITSTEEYPHLKPARYRRGFIHKNIMVLPRQ 475
Cdd:pfam12062 319 LEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPRQ 398

                         410       420       430
                  ....*....|....*....|....*....|.
gi 2462599750 476 TCGLFTHTIFYKEYPGGPKELDKSIQGGELF 506
Cdd:pfam12062 399 TCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
595-824 9.53e-38

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 142.10  E-value: 9.53e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 595 LPKFLVIGPQKTGTTALYLFLVMHPSILSNSPSpktfEEVQFFNRNNYHRGIDWYMDFFPVPSNVTTDFLFEKSANYF-- 672
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKS----EEPHLFNNHNRSPFLEWYPGDTYFDVAEGPVRLNALPSPRIik 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 673 -HSEEAPKRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALKFSFYEVisagprapselRALQKRCLVPGWYASH 751
Cdd:pfam00685  77 tHLPLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV-----------EDFLNGKVNCGSYFDH 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 752 IERWLVYFPPFQLLIIDGQQLRTDPATVMDEVQKFLGVLPHY----NYSEALTFDSHKGFWCQLL-------EEGKTKCL 820
Cdd:pfam00685 146 VKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEeeldKIVKHLSFENMKGNPCLNYsklpkevSPFFRKGL 225


                  ....
gi 2462599750 821 GKSK 824
Cdd:pfam00685 226 VGDW 229
 
Name Accession Description Interval E-value
HSNSD pfam12062
heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase ...
 76-506 0e+00

heparan sulfate-N-deacetylase; This family of proteins is are heparan sulfate N-deacetylase enzymes. This protein is found in eukaryotes. This proteinenzyme is often found associated with pfam00685.


Pssm-ID: 463450  Cd Length: 429  Bit Score: 868.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750  76 TDPTVLVFVESQYSSLGQDIIMILESSRFQYHIEIApgKGDLPVLIDKMKGKYILIIYENILKYINMDSWNRSLLDKYCV 155
Cdd:pfam12062   1 TDPKVLVFVESLYSQLGQEIIAILESNRFKYKTEIA--KKDLPVLTNKDKGRYSLIIYENYLKYLNMDKWNRELLDKYCR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 156 EYGVGVIGFHKTSEKSVQSFQLKGFPFSIYGNLAVKDCCINPHSPLIRVTKSSKLEKGSLPGTDWTVFQINHSAYQPVIF 235
Cdd:pfam12062  79 EYGVGIIGFFKANENSLLSAQLKGFPLFLHTNLRLKDCTVNPKSPLLRITRPGEVEQGPLPGDDWTVFQSNHSTYEPVLL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 236 AKVKTPENLSPSISKGAFYATIIHDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVG 315
Cdd:pfam12062 159 AKVKSGEESPSPGLDAALLATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFLDALSYLTGKRLSLSLDRYILVDIDDIFVG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 316 KEGTRMNTNDVKALLDTQNLLRAQITNFTFNLGFSGKFYHTGTEEEDEGDDCLLGSVDEFWWFPHMWSHMQPHLFHNESS 395
Cdd:pfam12062 239 KEGTRMKVEDVKALLETQNRLRTLVPNFTFNLGFSGKYFHNGTDEEDEGDDLLLENVKEFWWFPHMWSHMQPHLFHNQTV 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 396 LVEQMILNKKFALEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKKVWNIKITSTEEYPHLKPARYRRGFIHKNIMVLPRQ 475
Cdd:pfam12062 319 LEEQMLLNKKFAQEHGIPTDSGYAVAPHHSGVYPVHEQLYEAWKKVWNIKVTSTEEYPHLKPARLRRGFIHRGIMVLPRQ 398

                         410       420       430
                  ....*....|....*....|....*....|.
gi 2462599750 476 TCGLFTHTIFYKEYPGGPKELDKSIQGGELF 506
Cdd:pfam12062 399 TCGLFTHTIFYDEYPGGPKKLDKSIQGGELF 429
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
595-824 9.53e-38

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 142.10  E-value: 9.53e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 595 LPKFLVIGPQKTGTTALYLFLVMHPSILSNSPSpktfEEVQFFNRNNYHRGIDWYMDFFPVPSNVTTDFLFEKSANYF-- 672
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKS----EEPHLFNNHNRSPFLEWYPGDTYFDVAEGPVRLNALPSPRIik 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 673 -HSEEAPKRAASLVPKAKIITILIDPSDRAYSWYQHQRSHEDPAALKFSFYEVisagprapselRALQKRCLVPGWYASH 751
Cdd:pfam00685  77 tHLPLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFV-----------EDFLNGKVNCGSYFDH 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 752 IERWLVYFPPFQLLIIDGQQLRTDPATVMDEVQKFLGVLPHY----NYSEALTFDSHKGFWCQLL-------EEGKTKCL 820
Cdd:pfam00685 146 VKGWWKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEeeldKIVKHLSFENMKGNPCLNYsklpkevSPFFRKGL 225


                  ....
gi 2462599750 821 GKSK 824
Cdd:pfam00685 226 VGDW 229
Sulfotransfer_3 pfam13469
Sulfotransferase family;
600-789 5.22e-11

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 62.31  E-value: 5.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 600 VIGPQKTGTTALYLFLVMHPSILSnspspktFEEVQFFNRNNYHRGIDWYMDF---FPVPSNvtTDFLFEKSANYFHSEE 676
Cdd:pfam13469   3 IVGLPRSGTTLLHRLLAAHPDVRP-------PEETWFVIPRILALLQAWGKSLealARVPSY--ARWLCDKSPSHLFHLD 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462599750 677 APKRAaslVPKAKIITILIDPSDRAYSWYQHqrshedpaalkfsfyevISAGPRAPSELRALQKRCLVPGWYASHIERWL 756
Cdd:pfam13469  74 LLLKA---FPDAKFIHLHRDPVDTVISSYCS-----------------LFGFTLSSYSTAFLRDIGLALARWSRAYERLM 133

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 2462599750 757 ---VYFPPFQLLIIDGQQLRTDPATVMDEVQKFLGV 789
Cdd:pfam13469 134 aarARVPPGRFLDVRYEDLVADPEGTLRRILEFLGL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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