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Conserved domains on  [gi|2462602726|ref|XP_054208666|]
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peptidyl-glycine alpha-amidating monooxygenase isoform X21 [Homo sapiens]

Protein Classification

peptidyl-glycine alpha-amidating monooxygenase( domain architecture ID 10471209)

peptidyl-glycine alpha-amidating monooxygenase is a bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 518-795 1.24e-134

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


:

Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 402.41  E-value: 1.24e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 518 EALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSkFVYQQIGlgPIEEDTILVIDPNNAaVLQSSGKNLFY 597
Cdd:cd14958     1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDGG-FLRSWGAGLFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 598 LPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYCNSRIVQF 677
Cdd:cd14958    77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 678 SPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTKeFVREIKHSSFGRnVFAISYIP- 756
Cdd:cd14958   156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDE-DGRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2462602726 757 GLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRK 795
Cdd:cd14958   229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGK 267
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 196-342 1.58e-61

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


:

Pssm-ID: 461021  Cd Length: 157  Bit Score: 204.79  E-value: 1.58e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 196 IAGMYLMMSV---DTVIPAGEKVVNSDISCHYK--NYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 264
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 265 LP--QAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDMFRTIP 342
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 59-168 4.88e-26

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


:

Pssm-ID: 460053  Cd Length: 130  Bit Score: 103.87  E-value: 4.88e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726  59 LDIRMPGVT-PKQSDTYFCMSMRIP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 131
Cdd:pfam01082   1 FDLLNPNVTvPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462602726 132 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 168
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 518-795 1.24e-134

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 402.41  E-value: 1.24e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 518 EALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSkFVYQQIGlgPIEEDTILVIDPNNAaVLQSSGKNLFY 597
Cdd:cd14958     1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDGG-FLRSWGAGLFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 598 LPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYCNSRIVQF 677
Cdd:cd14958    77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 678 SPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTKeFVREIKHSSFGRnVFAISYIP- 756
Cdd:cd14958   156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDE-DGRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2462602726 757 GLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRK 795
Cdd:cd14958   229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGK 267
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 196-342 1.58e-61

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 461021  Cd Length: 157  Bit Score: 204.79  E-value: 1.58e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 196 IAGMYLMMSV---DTVIPAGEKVVNSDISCHYK--NYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 264
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 265 LP--QAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDMFRTIP 342
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 59-168 4.88e-26

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 460053  Cd Length: 130  Bit Score: 103.87  E-value: 4.88e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726  59 LDIRMPGVT-PKQSDTYFCMSMRIP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 131
Cdd:pfam01082   1 FDLLNPNVTvPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462602726 132 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 168
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
519-733 1.97e-13

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 70.88  E-value: 1.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 519 ALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYqqigLGPIEEDTILVIDPNNAAVLQS--SGKNlf 596
Cdd:COG3391    38 AAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLY----VANSGSGRVSVIDLATGKVVATipVGGG-- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 597 ylPHGLSIDKDGNY-WVTDVALHQVFKLDPNNKEgpvliLGRSMQPGSdqnhfcQPTDVAVDPGTGAIYVSDGYCN--SR 673
Cdd:COG3391   112 --PRGLAVDPDGGRlYVADSGNGRVSVIDTATGK-----VVATIPVGA------GPHGIAVDPDGKRLYVANSGSNtvSV 178

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462602726 674 IVQ-FSP-SGKFITQWgeessgssPLPGQftvPHSLALVPLLGQLCVADRENG-------RIQCFKTDT 733
Cdd:COG3391   179 IVSvIDTaTGKVVATI--------PVGGG---PVGVAVSPDGRRLYVANRGSNtsnggsnTVSVIDLAT 236
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 701-729 6.70e-04

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 37.77  E-value: 6.70e-04
                          10        20
                  ....*....|....*....|....*....
gi 2462602726 701 FTVPHSLALVPLlGQLCVADRENGRIQCF 729
Cdd:pfam01436   1 FNRPHGVAVDSN-GDIYVADSENHRVQVF 28
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 518-795 1.24e-134

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 402.41  E-value: 1.24e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 518 EALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSkFVYQQIGlgPIEEDTILVIDPNNAaVLQSSGKNLFY 597
Cdd:cd14958     1 MVSSWPSASLKLGQVSGVAVDSLGNGVVFHRGGRVWDANSFDA-NVYVFKG--PIEEDTILVFDPDGG-FLRSWGAGLFY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 598 LPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYCNSRIVQF 677
Cdd:cd14958    77 MPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEPGSDQTHFCKPTDVAVAP-DGDIFVADGYCNSRIVKF 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 678 SPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTKeFVREIKHSSFGRnVFAISYIP- 756
Cdd:cd14958   156 SPDGKLLKSWGEPGSG----PGQFNLPHSIALDE-DGRVYVADRENGRIQVFDADGK-FLTEWTNPELGR-PYALAIDPd 228

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2462602726 757 GLLFAVNGKPHFGDQEPVQGFVMNFSNGEIIDIFKPVRK 795
Cdd:cd14958   229 GLLYVVDGPPRLNRSLPVRGFVIRIGKGLILGRFGPGGK 267
Cu2_monoox_C pfam03712
Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal ...
 196-342 1.58e-61

Copper type II ascorbate-dependent monooxygenase, C-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 461021  Cd Length: 157  Bit Score: 204.79  E-value: 1.58e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 196 IAGMYLMMSV---DTVIPAGEKVVNSDISCHYK--NYPM-----HVFAYRVHTHHLGKVVSGYRVRNGQ-WTLIGRQSPQ 264
Cdd:pfam03712   2 DAGILLLGTVyspKMAIPPGQKVFHLEGYCTIDctDKALpesgiHPFASRLHTHLLGRVVSGYHVRDGQeWPLIGRDNPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 265 LP--QAFYPVGHPVDVSFGDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYmeakHAVSFMTCTQNVAPDMFRTIP 342
Cdd:pfam03712  82 SPhyQEFYPLEKEVTVLPGDVLAARCTYNTEDRTKVTLGGFTISDEMCNFYIMYY----PRTQLEVCKSSGPPEYLWNYF 157
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 533-750 8.85e-38

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 142.46  E-value: 8.85e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 533 SGVALDPKNNLVIFHRGDHvwdgnsfdskfvyqqiglgpieedTILVIDPNNAAVLQ--SSGKNL--FYLPHGLSIDKDG 608
Cdd:cd05819    11 QGIAVDSSGNIYVADTGNN------------------------RIQVFDPDGNFITSfgSFGSGDgqFNEPAGVAVDSDG 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 609 NYWVTDVALHQVFKLDPNNKEgpVLILGRSmqpGSDQNHFCQPTDVAVDPgTGAIYVSDgYCNSRIVQFSPSGKFITQWG 688
Cdd:cd05819    67 NLYVADTGNHRIQKFDPDGNF--LASFGGS---GDGDGEFNGPRGIAVDS-SGNIYVAD-TGNHRIQKFDPDGEFLTTFG 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462602726 689 EESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTkEFVREIKHSSFGRNVF 750
Cdd:cd05819   140 SGGSG----PGQFNGPTGVAVDS-DGNIYVADTGNHRIQVFDPDG-NFLTTFGSTGTGPGQF 195
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 590-750 1.03e-28

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 116.26  E-value: 1.03e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 590 SSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegpvlILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSDGY 669
Cdd:cd05819     1 GTGPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPDGN-----FITSFGSFGSGDGQFNEPAGVAVDS-DGNLYVADTG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 670 cNSRIVQFSPSGKFITQWGeeSSGSSplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTkEFVREIKHSSFGRNV 749
Cdd:cd05819    75 -NHRIQKFDPDGNFLASFG--GSGDG--DGEFNGPRGIAVDS-SGNIYVADTGNHRIQKFDPDG-EFLTTFGSGGSGPGQ 147


                  .
gi 2462602726 750 F 750
Cdd:cd05819   148 F 148
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 596-732 1.11e-27

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 113.15  E-value: 1.11e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 596 FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegpvlILGRSMQPGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIV 675
Cdd:cd14956   106 FNAPRGVAVDADGNLYVADFGNQRIQKFDPDGS-----FLRQWGGTGIEPGSFNYPRGVAVDPD-GTLYVADTY-NDRIQ 178

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462602726 676 QFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTD 732
Cdd:cd14956   179 VFDNDGAFLRKWGGRGTG----PGQFNYPYGIAIDP-DGNVFVADFGNNRIQKFTAD 230
Cu2_monooxygen pfam01082
Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal ...
 59-168 4.88e-26

Copper type II ascorbate-dependent monooxygenase, N-terminal domain; The N and C-terminal domains of members of this family adopt the same PNGase F-like fold.


Pssm-ID: 460053  Cd Length: 130  Bit Score: 103.87  E-value: 4.88e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726  59 LDIRMPGVT-PKQSDTYFCMSMRIP-VDEEAFVIDFKP---RASMDTVHHMLLFGCnmPSSTGSYWFCDEGTCTDKAN-- 131
Cdd:pfam01082   1 FDLLNPNVTvPAKDTTYWCTVFKLPdLTKKHHIIRFEPviqPGNEGLVHHMLLYEC--EGDPNEPSPGYGGDCYSADNmp 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 2462602726 132 --------ILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHY 168
Cdd:pfam01082  79 ddldpcssVIAAWAVGGGGFTYPEEVGLPIGGDGDPRYVMLEVHY 123
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 591-732 7.43e-25

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 105.35  E-value: 7.43e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 591 SGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNkeGPVLILGRSmqpGSDQNHFCQPTDVAVDpGTGAIYVSDGYc 670
Cdd:cd14955   104 SGDGQFNSPSGIAVDSAGNVYVTDSGNNRIQKFDSSG--TFITKWGSF---GSGDGQFNSPTGIAVD-SAGNVYVADTG- 176

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462602726 671 NSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCFKTD 732
Cdd:cd14955   177 NNRIQKFTSTGTFLTKWGSEGSG----DGQFNAPYGIA-VDSAGNVYVADTGNNRIQKFDSS 233
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 533-727 3.59e-23

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 100.09  E-value: 3.59e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 533 SGVALDPKNNLVIFHRGDH---VWDGnsfDSKFVYQQIGLG--------PI-----EEDTILVIDPNNAAVLQ------- 589
Cdd:cd05819    58 AGVAVDSDGNLYVADTGNHriqKFDP---DGNFLASFGGSGdgdgefngPRgiavdSSGNIYVADTGNHRIQKfdpdgef 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 590 -------SSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNkeGPVLILGrsmQPGSDQNHFCQPTDVAVDPgTGA 662
Cdd:cd05819   135 lttfgsgGSGPGQFNGPTGVAVDSDGNIYVADTGNHRIQVFDPDG--NFLTTFG---STGTGPGQFNYPTGIAVDS-DGN 208

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462602726 663 IYVSDGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQ 727
Cdd:cd05819   209 IYVADSG-NNRVQVFDPDGAGFGGNGNFLGS----DGQFNRPSGLAVDS-DGNLYVADTGNNRIQ 267
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 531-729 6.39e-23

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 99.57  E-value: 6.39e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 531 QVSGVALDPKNNLvifhrgdHVWD-GNS----FDSKFVY------------QQIGLGPIEEDT---ILVIDPNNAAV--L 588
Cdd:cd14955    64 SPTGIAVDSDGNV-------YVADtGNHriqkFDSTGTFltkwgssgsgdgQFNSPSGIAVDSagnVYVTDSGNNRIqkF 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 589 QSSGKNL------------FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNkeGPVLILGRsmqPGSDQNHFCQPTDVAV 656
Cdd:cd14955   137 DSSGTFItkwgsfgsgdgqFNSPTGIAVDSAGNVYVADTGNNRIQKFTSTG--TFLTKWGS---EGSGDGQFNAPYGIAV 211

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462602726 657 DpGTGAIYVSDGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCF 729
Cdd:cd14955   212 D-SAGNVYVADTG-NNRIQKFDSSGTFITKWGSEGSG----DGQFNSPSGIA-VDSAGNVYVADSGNNRIQKF 277
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 575-738 9.13e-23

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 98.89  E-value: 9.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 575 DTILVIDPNNAAVL--------------QSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegPVLILGRsmq 640
Cdd:cd14956    24 DNVYVADARNGRIQvfdkdgtflrrfgtTGDGPGQFGRPRGLAVDKDGWLYVADYWGDRIQVFTLTGE--LQTIGGS--- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 641 PGSDQNHFCQPTDVAVDPgTGAIYVSDGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVAD 720
Cdd:cd14956    99 SGSGPGQFNAPRGVAVDA-DGNLYVADFG-NQRIQKFDPDGSFLRQWGGTGIE----PGSFNYPRGVAVDP-DGTLYVAD 171

                         170
                  ....*....|....*...
gi 2462602726 721 RENGRIQCFKTDTKeFVR 738
Cdd:cd14956   172 TYNDRIQVFDNDGA-FLR 188
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 591-737 2.38e-22

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 98.03  E-value: 2.38e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 591 SGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNkeGPVLILGRSmqpGSDQNHFCQPTDVAVDPgTGAIYVSDGYc 670
Cdd:cd14955    57 SGDGQFYSPTGIAVDSDGNVYVADTGNHRIQKFDSTG--TFLTKWGSS---GSGDGQFNSPSGIAVDS-AGNVYVTDSG- 129

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462602726 671 NSRIVQFSPSGKFITQWGeeSSGSSplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCFkTDTKEFV 737
Cdd:cd14955   130 NNRIQKFDSSGTFITKWG--SFGSG--DGQFNSPTGIA-VDSAGNVYVADTGNNRIQKF-TSTGTFL 190
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 591-732 1.72e-21

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 95.34  E-value: 1.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 591 SGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkeGPVLILGRSmqPGSDQNHFCQPTDVAVDpGTGAIYVSDGYc 670
Cdd:cd14955    10 SGDGQFNSPSGIAVDSAGNVYVADTGNNRIQKFDST---GTFLTKWGS--SGSGDGQFYSPTGIAVD-SDGNVYVADTG- 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462602726 671 NSRIVQFSPSGKFITQWGEESSGSsplpGQFTVPHSLAlVPLLGQLCVADRENGRIQCFKTD 732
Cdd:cd14955    83 NHRIQKFDSTGTFLTKWGSSGSGD----GQFNSPSGIA-VDSAGNVYVTDSGNNRIQKFDSS 139
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 592-747 7.44e-20

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 90.34  E-value: 7.44e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 592 GKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKegPVLILGRSMQpgsdqnhFCQPTDVAVDPGTGAIYVSDGYcN 671
Cdd:cd14962    52 GPNRFVSPIGVAIDANGNLYVSDAELGKVFVFDRDGK--FLRAIGAGAL-------FKRPTGIAVDPAGKRLYVVDTL-A 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462602726 672 SRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTKeFVReikhsSFGR 747
Cdd:cd14962   122 HKVKVFDLDGRLLFDIGKRGSG----PGEFNLPTDLAVDR-DGNLYVTDTMNFRVQIFDADGK-FLR-----SFGE 186
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 642-729 4.26e-19

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 88.40  E-value: 4.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 642 GSDQNHFCQPTDVAVDpGTGAIYVSDgYCNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLAlVPLLGQLCVADR 721
Cdd:cd14955     9 GSGDGQFNSPSGIAVD-SAGNVYVAD-TGNNRIQKFDSTGTFLTKWGSSGSG----DGQFYSPTGIA-VDSDGNVYVADT 81


                  ....*...
gi 2462602726 722 ENGRIQCF 729
Cdd:cd14955    82 GNHRIQKF 89
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 529-729 9.38e-19

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 87.34  E-value: 9.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 529 PGQ---VSGVALDPKNNLVIfhrgdhvwdgnsfdSKFVYQQIglgpieedtiLVIDPNNAAVLQSSGKNL----FYLPHG 601
Cdd:cd14956   103 PGQfnaPRGVAVDADGNLYV--------------ADFGNQRI----------QKFDPDGSFLRQWGGTGIepgsFNYPRG 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 602 LSIDKDGNYWVTDVALH--QVFkldpNNKEGPVLILGrsmQPGSDQNHFCQPTDVAVDPgTGAIYVSDGYcNSRIVQFSP 679
Cdd:cd14956   159 VAVDPDGTLYVADTYNDriQVF----DNDGAFLRKWG---GRGTGPGQFNYPYGIAIDP-DGNVFVADFG-NNRIQKFTA 229

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 2462602726 680 SGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCF 729
Cdd:cd14956   230 DGTFLTSWGSPGTG----PGQFKNPWGVVVDA-DGTVYVADSNNNRVQRF 274
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 534-729 6.08e-18

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 84.91  E-value: 6.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 534 GVALDPKNNLVIFHRGDH---VWDGN-SFDSKFVYQQIGLGPIEEdtilvidpnnaavlqssgknlfylPHGLSIDKDGN 609
Cdd:cd14954   122 GVAVDSEGRIYVSDTRNHrvqVFDSDgQFIRKFGFEGAGPGQLDS------------------------PRGVAVNPDGN 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 610 YWVTDVALHQVFKLDPNNKegPVLILGrsmQPGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGKFITQWGE 689
Cdd:cd14954   178 IVVSDFNNHRLQVFDPDGQ--FLRFFG---SEGSGNGQFKRPRGVAVDDE-GNIIVADSG-NHRVQVFSPDGEFLCSFGT 250

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 2462602726 690 ESSGssplPGQFTVPHSLALVPlLGQLCVADRENGRIQCF 729
Cdd:cd14954   251 EGNG----EGQFDRPSGVAVTP-DGRIVVVDRGNHRIQVF 285
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 590-754 8.48e-18

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 84.62  E-value: 8.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 590 SSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPVLILGRSmqPGSDQNHFCQPTDVAVDpGTGAIYVSD 667
Cdd:cd14957    11 GSGNGQFNTPRGIAVDSAGNIYVADTGNNriQVF-----TSSGVYSYSIGS--GGTGSGQFNSPYGIAVD-SNGNIYVAD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 668 gYCNSRIVQFSPSGKFITQWGeeSSGSSplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCFkTDTKEFVREIKHSSFGR 747
Cdd:cd14957    83 -TDNNRIQVFNSSGVYQYSIG--TGGSG--DGQFNGPYGIA-VDSNGNIYVADTGNHRIQVF-TSSGTFSYSIGSGGTGP 155


                  ....*..
gi 2462602726 748 NVFAISY 754
Cdd:cd14957   156 GQFNGPQ 162
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 572-788 1.22e-17

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 83.88  E-value: 1.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 572 IEEDTILVIDPNN--AAVLQSSGKNL------------FYLPHGLSIDKDGNYWVTDVA--LHQVFkldpnNKEGPVLil 635
Cdd:cd14963    17 VSDGRIYVADTNNhrVQVFDYEGKFKksfggpgtgpgeFKYPYGIAVDSDGNIYVADLYngRIQVF-----DPDGKFL-- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 636 gRSMQPGSDQNHFCQPTDVAVDPGTgaIYVSD-GYcnSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLG 714
Cdd:cd14963    90 -KYFPEKKDRVKLISPAGLAIDDGK--LYVSDvKK--HKVIVFDLEGKLLLEFGKPGSE----PGELSYPNGIAVDE-DG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 715 QLCVADRENGRIQCFKTDTKeFVREIKHSSFGRNVFA----ISYIP-GLLFAV------------NGKPH--FGDQEPVQ 775
Cdd:cd14963   160 NIYVADSGNGRIQVFDKNGK-FIKELNGSPDGKSGFVnprgIAVDPdGNLYVVdnlshrvyvfdeQGKELftFGGRGKDD 238

                         250
                  ....*....|...
gi 2462602726 776 GfVMNFSNGEIID 788
Cdd:cd14963   239 G-QFNLPNGLFID 250
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 590-729 1.76e-17

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 83.47  E-value: 1.76e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 590 SSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpNNKEGPVLILGrsmQPGSDQNHFCQPTDVAVDpGTGAIYVSD 667
Cdd:cd14957   152 GTGPGQFNGPQGIAVDSDGNIYVADTGNHriQVF----TSSGTFQYTFG---SSGSGPGQFSDPYGIAVD-SDGNIYVAD 223

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462602726 668 gYCNSRIVQFSPSGKFITQWGeeSSGSSplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCF 729
Cdd:cd14957   224 -TGNHRIQVFTSSGAYQYSIG--TSGSG--NGQFNYPYGIA-VDNDGKIYVADSNNNRIQVF 279
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 590-746 4.09e-14

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 73.45  E-value: 4.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 590 SSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPVL-ILGRSmqpGSDQNHFCQPTDVAVDPgTGAIYVS 666
Cdd:cd14957    58 GTGSGQFNSPYGIAVDSNGNIYVADTDNNriQVF-----NSSGVYQySIGTG---GSGDGQFNGPYGIAVDS-NGNIYVA 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 667 DGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPLlGQLCVADRENGRIQCFkTDTKEFVREIKHSSFG 746
Cdd:cd14957   129 DTG-NHRIQVFTSSGTFSYSIGSGGTG----PGQFNGPQGIAVDSD-GNIYVADTGNHRIQVF-TSSGTFQYTFGSSGSG 201
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 568-750 8.84e-14

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 72.58  E-value: 8.84e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 568 GLGPIEEDTILVIDPNN--AAVLQSSGKNL------------FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkegpvl 633
Cdd:cd14954    28 GVAVDKDGRIIVADRSNnrVQVFDPDGKFLrkfgsygsrdgqFDRPAGVAVNSRGRIIVADKDNHRIQVFDLN------- 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 634 ilGRSM----QPGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGKFITQWGEESsgssPLPGQFTVPHSLAL 709
Cdd:cd14954   101 --GRFLlkfgERGTKNGQFNYPWGVAVDSE-GRIYVSDTR-NHRVQVFDSDGQFIRKFGFEG----AGPGQLDSPRGVAV 172

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 2462602726 710 VPLlGQLCVADRENGRIQCFKTDTKeFVREIKHSSFGRNVF 750
Cdd:cd14954   173 NPD-GNIVVSDFNNHRLQVFDPDGQ-FLRFFGSEGSGNGQF 211
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 596-738 1.04e-13

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 72.58  E-value: 1.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 596 FYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGP-VLILGRSmqpGSDQNHFCQPTDVAVDpGTGAIYVSDGYcNS 672
Cdd:cd14954    23 LCRPWGVAVDKDGRIIVADRSNNrvQVF-----DPDGKfLRKFGSY---GSRDGQFDRPAGVAVN-SRGRIIVADKD-NH 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462602726 673 RIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLAlVPLLGQLCVADRENGRIQCFKTDTKeFVR 738
Cdd:cd14954    93 RIQVFDLNGRFLLKFGERGTK----NGQFNYPWGVA-VDSEGRIYVSDTRNHRVQVFDSDGQ-FIR 152
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 533-726 1.77e-13

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 72.18  E-value: 1.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 533 SGVALDPKNNLVIFHRGDHvwdgnsfdskfvyqqiglgpieedTILVIDPN-------------------NAAvlqssgk 593
Cdd:cd14953    26 SGVAVDAAGNLYVADRGNH------------------------RIRKITPDgvvttvagtgtagfadgggAAA------- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 594 nLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkeGPVL------ILGRSMQPGSDQNHFCQPTDVAVDPgTGAIYVSD 667
Cdd:cd14953    75 -QFNTPSGVAVDAAGNLYVADTGNHRIRKITPD---GVVStlagtgTAGFSDDGGATAAQFNYPTGVAVDA-AGNLYVAD 149

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462602726 668 GYcNSRIVQFSPSGKFITQWGEESSGSSPL-PG---QFTVPHSLAlVPLLGQLCVADRENGRI 726
Cdd:cd14953   150 TG-NHRIRKITPDGVVTTVAGTGGAGYAGDgPAtaaQFNNPTGVA-VDAAGNLYVADRGNHRI 210
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
519-733 1.97e-13

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 70.88  E-value: 1.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 519 ALDWPGVYLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYqqigLGPIEEDTILVIDPNNAAVLQS--SGKNlf 596
Cdd:COG3391    38 AAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLY----VANSGSGRVSVIDLATGKVVATipVGGG-- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 597 ylPHGLSIDKDGNY-WVTDVALHQVFKLDPNNKEgpvliLGRSMQPGSdqnhfcQPTDVAVDPGTGAIYVSDGYCN--SR 673
Cdd:COG3391   112 --PRGLAVDPDGGRlYVADSGNGRVSVIDTATGK-----VVATIPVGA------GPHGIAVDPDGKRLYVANSGSNtvSV 178

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462602726 674 IVQ-FSP-SGKFITQWgeessgssPLPGQftvPHSLALVPLLGQLCVADRENG-------RIQCFKTDT 733
Cdd:COG3391   179 IVSvIDTaTGKVVATI--------PVGGG---PVGVAVSPDGRRLYVANRGSNtsnggsnTVSVIDLAT 236
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
575-736 3.48e-13

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 70.43  E-value: 3.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 575 DTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEgpvLILGRSMQPGSdqnhfcQPTDV 654
Cdd:COG4257    80 NRIGRIDPKTGEITTFALPGGGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPATGE---VTEFPLPTGGA------GPYGI 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 655 AVDPgTGAIYVSDgYCNSRIVQFSPSGKFITQWgeessgssPLPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTK 734
Cdd:COG4257   151 AVDP-DGNLWVTD-FGANAIGRIDPDTGTLTEY--------ALPTPGAGPRGLAVDP-DGNLWVADTGSGRIGRFDPKTG 219


                  ..
gi 2462602726 735 EF 736
Cdd:COG4257   220 TV 221
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 521-733 3.52e-13

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 70.77  E-value: 3.52e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 521 DWPGVYLLPgqvSGVALDPKNNLVIFHrgdhvwDGNS----FDSK-FVYQQIGlgPIEEDTILVIDPNNAAV-------- 587
Cdd:cd14961     5 GWPGTLNNP---TGVAVTPTGRVVVAD------DGNKriqvFDSDgNCLQQFG--PKGDAGQDIRYPLDVAVtpdghivv 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 588 ----------------LQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSmqpgsdQNHFCQP 651
Cdd:cd14961    74 tdagdrsvkvfsfdgrLKLFVRKSFSLPWGVAVNPSGEILVTDSEAGKLFVLTVDFKLGILKKGQKL------CSQLCRP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 652 TDVAVDPgTGAIYVSD-------GYCNSRIVQFSPSGKFITQWGeeSSGSSPLPGQFTVPHSLAlVPLLGQLCVADRENG 724
Cdd:cd14961   148 RFVAVSR-LGAVAVTEhlfangtRSSSTRVKVFSSGGQLLGQID--SFGLNLVFPSLICASGVA-FDSEGNVIVADTGSG 223


                  ....*....
gi 2462602726 725 RIQCFKTDT 733
Cdd:cd14961   224 AILCLGKPE 232
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 577-729 3.85e-13

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 70.31  E-value: 3.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 577 ILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNY-WVTDVALHQVFKLDPNNKEgpvliLGRSMQPGSDQNHFCQPTDVA 655
Cdd:cd14962    80 VFVFDRDGKFLRAIGAGALFKRPTGIAVDPAGKRlYVVDTLAHKVKVFDLDGRL-----LFDIGKRGSGPGEFNLPTDLA 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 656 VDPgTGAIYVSDGYcNSRIVQFSPSGKFITQWGE-------------------------ESS------------------ 692
Cdd:cd14962   155 VDR-DGNLYVTDTM-NFRVQIFDADGKFLRSFGErgdgpgsfarpkgiavdsegniyvvDAAfdnvqifnpegellltvg 232

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 2462602726 693 GSSPLPGQFTVPHSLAlVPLLGQLCVADRENGRIQCF 729
Cdd:cd14962   233 GPGSGPGEFYLPSGIA-IDKDDRIYVVDQFNRRIQVF 268
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
575-736 1.09e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 69.28  E-value: 1.09e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 575 DTILVIDPNNAAVLQSSgKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPnnKEGPV-LILGrsmqPGSDQNhfcqPTD 653
Cdd:COG4257    38 GRIGRLDPATGEFTEYP-LGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDP--KTGEItTFAL----PGGGSN----PHG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 654 VAVDPGtGAIYVSDGYcNSRIVQFSP-SGKFitqwgeeSSGSSPLPGQFtvPHSLALVPlLGQLCVADRENGRIQCFKTD 732
Cdd:COG4257   107 IAFDPD-GNLWFTDQG-GNRIGRLDPaTGEV-------TEFPLPTGGAG--PYGIAVDP-DGNLWVTDFGANAIGRIDPD 174


                  ....
gi 2462602726 733 TKEF 736
Cdd:COG4257   175 TGTL 178
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 523-729 1.35e-12

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 68.86  E-value: 1.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 523 PGVYLLPgqvSGVALDPKNNLVI---FHRGDHVWD--GNsFDSKFVYQQIGLGP-------IEEDTILVID--PNNAAVL 588
Cdd:cd14963    52 PGEFKYP---YGIAVDSDGNIYVadlYNGRIQVFDpdGK-FLKYFPEKKDRVKLispaglaIDDGKLYVSDvkKHKVIVF 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 589 QSSGKNLFYL------------PHGLSIDKDGNYWVTDVALHQVFKLDPNNKegPVLIL-GRSMQPGSdqnhFCQPTDVA 655
Cdd:cd14963   128 DLEGKLLLEFgkpgsepgelsyPNGIAVDEDGNIYVADSGNGRIQVFDKNGK--FIKELnGSPDGKSG----FVNPRGIA 201

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462602726 656 VDPgTGAIYVSDGYCNsRIVQFSPSGKFITQWGeeSSGSSPlpGQFTVPHSLALVPLlGQLCVADRENGRIQCF 729
Cdd:cd14963   202 VDP-DGNLYVVDNLSH-RVYVFDEQGKELFTFG--GRGKDD--GQFNLPNGLFIDDD-GRLYVTDRENNRVAVY 268
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
575-740 1.74e-12

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 68.51  E-value: 1.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 575 DTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQpgsdqnhfcQPTDV 654
Cdd:COG4257   123 NRIGRLDPATGEVTEFPLPTGGAGPYGIAVDPDGNLWVTDFGANAIGRIDPDTGTLTEYALPTPGA---------GPRGL 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 655 AVDPgTGAIYVSDGYcNSRIVQFSPSGKFITQWgeessgssPLPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTK 734
Cdd:COG4257   194 AVDP-DGNLWVADTG-SGRIGRFDPKTGTVTEY--------PLPGGGARPYGVAVDG-DGRVWFAESGANRIVRFDPDTE 262


                  ....*.
gi 2462602726 735 EFVREI 740
Cdd:COG4257   263 LTEYVL 268
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 577-730 2.98e-12

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 67.76  E-value: 2.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 577 ILVIDPNNAAVL--QSSGKNLFYL-------PHGLSIDKDGNYWVTDVALHQVFKLDPNNKegpvlILGRSMQPGSDQNH 647
Cdd:cd14960    77 IIIADYDNKWVSifSPDGKFKSKIgagklmgPKGVAVDRNGHIIVVDNKACCVFIFQPNGK-----LVTRFGSRGNGDRQ 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 648 FCQPTDVAVDPgTGAIYVSDgYCNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPLlGQLCVADRENGRIQ 727
Cdd:cd14960   152 FAGPHFAAVNN-NNEIIVTD-FHNHSVKVFNAEGEFLFKFGSNGEG----NGQFNAPTGVAVDSN-GNIIVADWGNSRIQ 224


                  ...
gi 2462602726 728 CFK 730
Cdd:cd14960   225 VFD 227
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 533-677 4.20e-12

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 67.34  E-value: 4.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 533 SGVALDPKNNLVIFHRGDHVwdgnsfdskfvyqqiglgpieedtILVIDPNNAAVL----QSSGKNLFYLPHGLSIDKDG 608
Cdd:cd05819   152 TGVAVDSDGNIYVADTGNHR------------------------IQVFDPDGNFLTtfgsTGTGPGQFNYPTGIAVDSDG 207

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462602726 609 NYWVTDVALHQVFKLDPNNKEGPvlilgrsmQPGSDQNH---FCQPTDVAVDPgTGAIYVSDGYcNSRIVQF 677
Cdd:cd05819   208 NIYVADSGNNRVQVFDPDGAGFG--------GNGNFLGSdgqFNRPSGLAVDS-DGNLYVADTG-NNRIQVF 269
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
599-736 1.49e-11

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 65.81  E-value: 1.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 599 PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLILGRsmqpgsdqnhFCQPTDVAVDPgTGAIYVSDGYcNSRIVQFS 678
Cdd:COG4257    19 PRDVAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGG----------GSGPHGIAVDP-DGNLWFTDNG-NNRIGRID 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 2462602726 679 PSGKFITQWgeessgssPLPGQFTVPHSLALVPlLGQLCVADRENGRIQCFKTDTKEF 736
Cdd:COG4257    87 PKTGEITTF--------ALPGGGSNPHGIAFDP-DGNLWFTDQGGNRIGRLDPATGEV 135
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 533-726 5.45e-11

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 64.86  E-value: 5.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 533 SGVALDPKNNLVIFHRGDHVwdgnsfdskfvyqqiglgpieedtILVIDPN--------NAAVLQSSGKN----LFYLPH 600
Cdd:cd14953   135 TGVAVDAAGNLYVADTGNHR------------------------IRKITPDgvvttvagTGGAGYAGDGPataaQFNNPT 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 601 GLSIDKDGNYWVTDVALHQVFKLDPNnkeGPVL-ILGRSMQPGSDQNH-----FCQPTDVAVDpGTGAIYVSDgYCNSRI 674
Cdd:cd14953   191 GVAVDAAGNLYVADRGNHRIRKITPD---GVVTtVAGTGTAGFSGDGGataaqLNNPTGVAVD-AAGNLYVAD-SGNHRI 265

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462602726 675 VQFSPSGKFIT----QWGEESSGSSPLPGQFTVPHSLALVPlLGQLCVADRENGRI 726
Cdd:cd14953   266 RKITPAGVVTTvaggGAGFSGDGGPATSAQFNNPTGVAVDA-AGNLYVADTGNNRI 320
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 626-729 1.66e-10

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 62.95  E-value: 1.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 626 NNKEGPVLILGRSmqpGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPH 705
Cdd:cd14954     4 RAKGRPLLSFGKE---GSKDGELCRPWGVAVDKD-GRIIVADRS-NNRVQVFDPDGKFLRKFGSYGSR----DGQFDRPA 74

                          90       100
                  ....*....|....*....|....
gi 2462602726 706 SLAlVPLLGQLCVADRENGRIQCF 729
Cdd:cd14954    75 GVA-VNSRGRIIVADKDNHRIQVF 97
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 599-726 2.66e-10

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 61.45  E-value: 2.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 599 PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLilgrsmqPGSDQNhfcQPTDVAVDpGTGAIYVSDGYcNSRIVQFS 678
Cdd:cd14952    12 PGGVAVDAAGNVYVADSGNNRVLKLAAGSTTQTVL-------PFTGLY---QPQGVAVD-AAGTVYVTDFG-NNRVLKLA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2462602726 679 PSgkfitqwgeeSSGSSPLPgqFT---VPHSLAlVPLLGQLCVADRENGRI 726
Cdd:cd14952    80 AG----------STTQTVLP--FTglnDPTGVA-VDAAGNVYVADTGNNRV 117
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 641-729 2.69e-10

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 62.28  E-value: 2.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 641 PGSDQNHFCQPTDVAVDPGtGAIYVSDGYcNSRIVQFSPSGKFITQWGeeSSGSSplPGQFTVPHSLAlVPLLGQLCVAD 720
Cdd:cd14957    10 NGSGNGQFNTPRGIAVDSA-GNIYVADTG-NNRIQVFTSSGVYSYSIG--SGGTG--SGQFNSPYGIA-VDSNGNIYVAD 82


                  ....*....
gi 2462602726 721 RENGRIQCF 729
Cdd:cd14957    83 TDNNRIQVF 91
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 596-726 8.41e-10

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 61.01  E-value: 8.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 596 FYLPHGLSIDKDGNYWVTDVALHQVFKLDPNnkeGPVLILGRSMQPGSD-----QNHFCQPTDVAVDPGtGAIYVSDGYc 670
Cdd:cd14953    22 FNSPSGVAVDAAGNLYVADRGNHRIRKITPD---GVVTTVAGTGTAGFAdgggaAAQFNTPSGVAVDAA-GNLYVADTG- 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 671 NSRIVQFSPSGKFITQWGEESSGSSPLPG----QFTVPHSLAlVPLLGQLCVADRENGRI 726
Cdd:cd14953    97 NHRIRKITPDGVVSTLAGTGTAGFSDDGGataaQFNYPTGVA-VDAAGNLYVADTGNHRI 155
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 640-732 1.40e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 56.91  E-value: 1.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 640 QPGSDQNHFCQPTDVAVDPGTGAIYVSDGycNSRIVQFSPSGKFITQWGEESSGssplPGQFTVPHSLALVPlLGQLCVA 719
Cdd:cd14956     4 GRGSGPGQFKDPRGIAVDADDNVYVADAR--NGRIQVFDKDGTFLRRFGTTGDG----PGQFGRPRGLAVDK-DGWLYVA 76

                          90
                  ....*....|...
gi 2462602726 720 DRENGRIQCFKTD 732
Cdd:cd14956    77 DYWGDRIQVFTLT 89
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 599-676 5.60e-08

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 54.52  E-value: 5.60e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462602726 599 PHGLSIDKDGNYWVTDVALHQVFKLDPNNKEGPVLilgrsmqPGSDQNHfcqPTDVAVDPgTGAIYVSDgYCNSRIVQ 676
Cdd:cd14952   180 PSGVAVDTAGNVYVTDHGNNRVLKLAAGSTTPTVL-------PFTGLNG---PLGVAVDA-AGNVYVAD-RGNDRVVK 245
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 599-726 2.28e-07

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 52.98  E-value: 2.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 599 PHGLSIDKDGNYWVTDVALHQVFKLDPnnkegpvlilGRSMQ---PGSDQNHfcqPTDVAVDPGtGAIYVSDGYcNSRIV 675
Cdd:cd14952    96 PTGVAVDAAGNVYVADTGNNRVLKLAA----------GSNTQtvlPFTGLSN---PDGVAVDGA-GNVYVTDTG-NNRVL 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462602726 676 QFsPSGkfitqwgeeSSGSSPLPgqFT---VPHSLAlVPLLGQLCVADRENGRI 726
Cdd:cd14952   161 KL-AAG---------STTQTVLP--FTglnSPSGVA-VDTAGNVYVTDHGNNRV 201
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 591-684 8.60e-07

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 51.50  E-value: 8.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 591 SGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPVLilgrsMQ---PGSDQNHFCQPTDVAVDPGTGAIYV 665
Cdd:cd14959    16 SGEGQFNSPSGFCLGEDEDILVADTNNHriQVF-----DKEGEFK-----FQfgiPGKRDGQLWYPNKVAVCRVTGRYVV 85

                          90       100
                  ....*....|....*....|
gi 2462602726 666 SD-GYCNSRIVQFSPSGKFI 684
Cdd:cd14959    86 TDrGNPRHRMQIFTKRGQFV 105
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 589-678 1.24e-06

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 51.11  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 589 QSSGKNLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPVLilgRSM-QPGSDQNHFCQPTDVAVDpGTGAIYV 665
Cdd:cd14957   198 SGSGPGQFSDPYGIAVDSDGNIYVADTGNHriQVF-----TSSGAYQ---YSIgTSGSGNGQFNYPYGIAVD-NDGKIYV 268

                          90
                  ....*....|...
gi 2462602726 666 SDGYcNSRIVQFS 678
Cdd:cd14957   269 ADSN-NNRIQVFN 280
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 529-730 3.31e-06

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 49.65  E-value: 3.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 529 PGQV---SGVALDPKNNLVIFHRGDHvW------DGnSFDSKFVYQQiGLGPI-----EEDTILVIDPNNAAVL--QSSG 592
Cdd:cd14960    60 PGQLqrpTGVAVTLNGDIIIADYDNK-WvsifspDG-KFKSKIGAGK-LMGPKgvavdRNGHIIVVDNKACCVFifQPNG 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 593 K------------NLFYLPHGLSIDKDGNYWVTDVALH--QVFkldpnNKEGPVLILGRSMQPGSDQnhFCQPTDVAVDP 658
Cdd:cd14960   137 KlvtrfgsrgngdRQFAGPHFAAVNNNNEIIVTDFHNHsvKVF-----NAEGEFLFKFGSNGEGNGQ--FNAPTGVAVDS 209

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462602726 659 gTGAIYVSDgYCNSRIVQFSPSGKFITQWGeesSGSSPLPGqftvPHSLALVPlLGQLCVADRENgriQCFK 730
Cdd:cd14960   210 -NGNIIVAD-WGNSRIQVFDSSGSFLSYIN---TSADPLYG----PQGLALTS-DGHVVVADSGN---HCFK 268
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 642-790 3.99e-06

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 49.19  E-value: 3.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 642 GSDQNHFCQPTDVAVDpGTGAIYVSDGYcNSRIVQFSPSGKFITQWGEESSGSsplpGQFTVPHSLALVPLLGQLCVADR 721
Cdd:cd14959    15 GSGEGQFNSPSGFCLG-EDEDILVADTN-NHRIQVFDKEGEFKFQFGIPGKRD----GQLWYPNKVAVCRVTGRYVVTDR 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462602726 722 ENG--RIQCFkTDTKEFVREikhssfgrnvFAISYI--PGLLfAVNGKPHFGDQEPVQGFVMNFS-NGEIIDIF 790
Cdd:cd14959    89 GNPrhRMQIF-TKRGQFVRK----------FGARYLqhVRGL-TVDAAGHIIVVESKVMRVFIFDeSGNVLKWF 150
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 642-735 1.37e-05

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 47.66  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 642 GSDQNHFCQPTDVAVDPgTGAIYVSD-GycNSRIVQFSPSGKFITQWGEESSGS----SPLP------------------ 698
Cdd:cd14961     4 GGWPGTLNNPTGVAVTP-TGRVVVADdG--NKRIQVFDSDGNCLQQFGPKGDAGqdirYPLDvavtpdghivvtdagdrs 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2462602726 699 ---------------GQFTVPHSLALVPLlGQLCVADRENGRIQCFKTDTKE 735
Cdd:cd14961    81 vkvfsfdgrlklfvrKSFSLPWGVAVNPS-GEILVTDSEAGKLFVLTVDFKL 131
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 572-732 1.87e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 47.19  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 572 IEEDTILVIDPNNAAV---LQSSGknlfyLPHGLSIDKDGNYWVTDvALHQVFKLDPNNKEgPVLILGRSMQPGSdqnhf 648
Cdd:COG3386    26 IPGGRIHRYDPDGGAVevfAEPSG-----RPNGLAFDPDGRLLVAD-HGRGLVRFDPADGE-VTVLADEYGKPLN----- 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 649 cQPTDVAVDPGtGAIYVSD---GYCNSRIVQFSPSGKFitqwgeessgsSPLPGQFTVPHSLALVPLLGQLCVADRENGR 725
Cdd:COG3386    94 -RPNDGVVDPD-GRLYFTDmgeYLPTGALYRVDPDGSL-----------RVLADGLTFPNGIAFSPDGRTLYVADTGAGR 160


                  ....*..
gi 2462602726 726 IQCFKTD 732
Cdd:COG3386   161 IYRFDLD 167
MALA cd12811
Mala s 1 allergenic protein and similar proteins; This family includes the yeast Malassezia ...
 651-756 7.69e-05

Mala s 1 allergenic protein and similar proteins; This family includes the yeast Malassezia sympodialis allergen Mala s 1 which is localized in the cell wall and exposed on the cell surface. It can elicit specific IgE and T-cell activity in patients with atopic eczema (AE), a chronic inflammatory disease. Mala s 1 does not show any significant sequence homology to characterized proteins. However, its structure is a beta-propeller which is a novel fold among allergens.


Pssm-ID: 411995 [Multi-domain]  Cd Length: 304  Bit Score: 45.70  E-value: 7.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 651 PTDVAVDPgTGAIYVSDGYCNSrIVQFSPSGKFITQWGEESSGSSPLPGqFTvphSLALVPLLGQLCVADRENGRIQCFK 730
Cdd:cd12811   123 FQDSAQDS-DGNSYVVGALPPA-IAKVSPDGKTVTPWFLEAPNGSTRPG-YT---GIAYIPEDNVLLASGGEPGQLTRFD 196

                          90       100       110
                  ....*....|....*....|....*....|
gi 2462602726 731 TD----TKEFVReIKHSSFGRNVFAIsYIP 756
Cdd:cd12811   197 LSsatpTPIPVK-ISGENFGGLDDGE-KLP 224
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
650-738 3.61e-04

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 43.08  E-value: 3.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 650 QPTDVAVDPgTGAIYVSDgYCNSRIVQFSPSGKFITQWgeessgsspLPGQFTVPHSLALVPLlGQLCVADRENGRIQCF 729
Cdd:COG4257    18 GPRDVAVDP-DGAVWFTD-QGGGRIGRLDPATGEFTEY---------PLGGGSGPHGIAVDPD-GNLWFTDNGNNRIGRI 85


                  ....*....
gi 2462602726 730 KTDTKEFVR 738
Cdd:COG4257    86 DPKTGEITT 94
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 701-729 6.70e-04

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 37.77  E-value: 6.70e-04
                          10        20
                  ....*....|....*....|....*....
gi 2462602726 701 FTVPHSLALVPLlGQLCVADRENGRIQCF 729
Cdd:pfam01436   1 FNRPHGVAVDSN-GDIYVADSENHRVQVF 28
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
663-763 3.04e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.06  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462602726 663 IYVSDGYcNSRIVQFSP-SGKFITQWgeeSSGSSPlpgqftvpHSLALVPLLGQLCVADRENGRIQCFKTDTKEFVREIK 741
Cdd:COG3391    82 LYVANSG-SGRVSVIDLaTGKVVATI---PVGGGP--------RGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIP 149

                          90       100
                  ....*....|....*....|....
gi 2462602726 742 hssFGRNVFAISYIP--GLLFAVN 763
Cdd:COG3391   150 ---VGAGPHGIAVDPdgKRLYVAN 170
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
572-625 3.23e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 40.39  E-value: 3.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2462602726 572 IEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSIDKDGNYWVTDVALHQVFKLDP 625
Cdd:COG4257   206 TGSGRIGRFDPKTGTVTEYPLPGGGARPYGVAVDGDGRVWFAESGANRIVRFDP 259
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 648-677 3.36e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 35.46  E-value: 3.36e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 2462602726 648 FCQPTDVAVDPGtGAIYVSDgYCNSRIVQF 677
Cdd:pfam01436   1 FNRPHGVAVDSN-GDIYVAD-SENHRVQVF 28
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 683-729 6.27e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 39.48  E-value: 6.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2462602726 683 FITQWGEESSGSsplpGQFTVPHSLAlVPLLGQLCVADRENGRIQCF 729
Cdd:cd14955     1 FVTQWGSYGSGD----GQFNSPSGIA-VDSAGNVYVADTGNNRIQKF 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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