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Conserved domains on  [gi|2462603905|ref|XP_054209231|]
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slit homolog 3 protein isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1125-1251 1.32e-31

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 120.22  E-value: 1.32e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905 1125 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKL 1202
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2462603905 1203 QKQPAVGINSPLYLGGIPTStglsaLRQGTDRPLGGFHGCIHEVRINNE 1251
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNGE 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-154 1.42e-25

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.18  E-value: 1.42e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905    4 DLDRNNITRITKmDFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELLFQSTpKLTRLDLSENQIQ 83
Cdd:COG4886    119 DLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLT-NLKELDLSNNQIT 195

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462603905   84 GIPrKAFRGITDVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNISRIlvTSFNHMPKIRTLRLHSNHL 154
Cdd:COG4886    196 DLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
472-774 2.17e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 2.17e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  472 TDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKikevregAFDGAASVQELMLTGNQLETVhGRVFRGLSGLKTLMLRS 551
Cdd:COG4886     74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSN 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  552 NLISCVSnDTFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLLSNPfncnchlawlgkwlrkrrivsgnprcqkpf 631
Cdd:COG4886    146 NQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ------------------------------ 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  632 fLKEIPiqdvaiqdftcdgneessCQLSprcpeqctcmetvvrcsnkGLRALprgmpkdvTELYLEGNHLTAVPRELSAL 711
Cdd:COG4886    194 -ITDLP------------------EPLG-------------------NLTNL--------EELDLSGNQLTDLPEPLANL 227

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462603905  712 RHLTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLRCIPVHAfnGLRSLRVLTLHGNDISS 774
Cdd:COG4886    228 TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
263-603 7.54e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 7.54e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  263 AFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKITEIAKGLFDglvslqllllnankinclrvntfqdLQNL 342
Cdd:COG4886    108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN-------------------------LTNL 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  343 NLLSLYDNKLQTISKGLfAPLQsiqtlhlaqnpfvcdcHLKWLadYLQDNPIETSGARCSSPRRLankrisqikskkfrc 422
Cdd:COG4886    162 KSLDLSNNQLTDLPEEL-GNLT----------------NLKEL--DLSNNQITDLPEPLGNLTNL--------------- 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  423 sgsedyrsrfssecfmdlvcpekcrcegTIVDCSNQKLVRIPSHLPEY--VTDLRLNDNEVSVLEAtgiFKKLPNLRKIN 500
Cdd:COG4886    208 ----------------------------EELDLSGNQLTDLPEPLANLtnLETLDLSNNQLTDLPE---LGNLTNLEELD 256

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  501 LSNNKIKEVREGAfdGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITT 580
Cdd:COG4886    257 LSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                          330       340
                   ....*....|....*....|...
gi 2462603905  581 ITPGAFTTLVSLSTINLLSNPFN 603
Cdd:COG4886    335 VTLTTLALSLSLLALLTLLLLLN 357
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 767-852 4.19e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 61.64  E-value: 4.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  767 LHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK---AGYKEPGIARCSSPEPMADRLLLTTPTHRFQCk 843
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC- 80


                   ....*....
gi 2462603905  844 gpvDINIVA 852
Cdd:TIGR00864   81 ---DEEYVA 86
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1011-1047 1.47e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.47e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462603905 1011 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFSGPFCE 1047
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 935-968 4.88e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462603905  935 DDCED-NDCENNATCVDGINNYVCICPPNYTGELC 968
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1060-1090 3.17e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.17e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2462603905 1060 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1090
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 893-931 3.38e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462603905  893 INTC-IQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQRCE 931
Cdd:cd00054      2 IDECaSGNPCQNGGTCV---NTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 972-1009 4.07e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.07e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462603905  972 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 1009
Cdd:cd00054      2 IDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 125-187 9.20e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.38  E-value: 9.20e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462603905  125 LNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR--RTVG-QFTLCMAPVHLRG 187
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvKVRQpEAALCAGPGALAG 67
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 1403-1458 3.32e-04

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member smart00041:

Pssm-ID: 473907  Cd Length: 82  Bit Score: 40.85  E-value: 3.32e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462603905  1403 SCATASKVPIMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLA 1458
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79
LRRNT smart00013
Leucine rich repeat N-terminal domain;
217-248 1.24e-03

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.68  E-value: 1.24e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462603905   217 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVE 248
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1309-1337 2.74e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.74e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462603905 1309 CLGHRCHH-GKCVATGTSYMCKCAEGYGGD 1337
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGK 30
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1125-1251 1.32e-31

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 120.22  E-value: 1.32e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905 1125 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKL 1202
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2462603905 1203 QKQPAVGINSPLYLGGIPTStglsaLRQGTDRPLGGFHGCIHEVRINNE 1251
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1118-1251 3.45e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 116.67  E-value: 3.45e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  1118 NISLQVATDKDNGILLY---KGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKG 1194
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462603905  1195 TPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTdrplgGFHGCIHEVRINNE 1251
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTP-----GFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1096-1249 3.61e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.13  E-value: 3.61e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905 1096 TVNFVGkDSYVELA-SAKVRPQANISLQVATDKDNGILLYKGD---NDPLALELYQGHVRLVYDsLSSPPTTVYSVETVN 1171
Cdd:cd00110      1 GVSFSG-SSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYD-LGSGSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462603905 1172 DGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTdrplgGFHGCIHEVRIN 1249
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP-----GFVGCIRDLKVN 151
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-154 1.42e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.18  E-value: 1.42e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905    4 DLDRNNITRITKmDFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELLFQSTpKLTRLDLSENQIQ 83
Cdd:COG4886    119 DLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLT-NLKELDLSNNQIT 195

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462603905   84 GIPrKAFRGITDVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNISRIlvTSFNHMPKIRTLRLHSNHL 154
Cdd:COG4886    196 DLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
472-774 2.17e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 2.17e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  472 TDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKikevregAFDGAASVQELMLTGNQLETVhGRVFRGLSGLKTLMLRS 551
Cdd:COG4886     74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSN 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  552 NLISCVSnDTFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLLSNPfncnchlawlgkwlrkrrivsgnprcqkpf 631
Cdd:COG4886    146 NQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ------------------------------ 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  632 fLKEIPiqdvaiqdftcdgneessCQLSprcpeqctcmetvvrcsnkGLRALprgmpkdvTELYLEGNHLTAVPRELSAL 711
Cdd:COG4886    194 -ITDLP------------------EPLG-------------------NLTNL--------EELDLSGNQLTDLPEPLANL 227

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462603905  712 RHLTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLRCIPVHAfnGLRSLRVLTLHGNDISS 774
Cdd:COG4886    228 TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
263-603 7.54e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 7.54e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  263 AFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKITEIAKGLFDglvslqllllnankinclrvntfqdLQNL 342
Cdd:COG4886    108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN-------------------------LTNL 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  343 NLLSLYDNKLQTISKGLfAPLQsiqtlhlaqnpfvcdcHLKWLadYLQDNPIETSGARCSSPRRLankrisqikskkfrc 422
Cdd:COG4886    162 KSLDLSNNQLTDLPEEL-GNLT----------------NLKEL--DLSNNQITDLPEPLGNLTNL--------------- 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  423 sgsedyrsrfssecfmdlvcpekcrcegTIVDCSNQKLVRIPSHLPEY--VTDLRLNDNEVSVLEAtgiFKKLPNLRKIN 500
Cdd:COG4886    208 ----------------------------EELDLSGNQLTDLPEPLANLtnLETLDLSNNQLTDLPE---LGNLTNLEELD 256

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  501 LSNNKIKEVREGAfdGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITT 580
Cdd:COG4886    257 LSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                          330       340
                   ....*....|....*....|...
gi 2462603905  581 ITPGAFTTLVSLSTINLLSNPFN 603
Cdd:COG4886    335 VTLTTLALSLSLLALLTLLLLLN 357
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 5-154 1.43e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 74.44  E-value: 1.43e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905    5 LDRNNITRITkmDFAGLKNLRVLHLEDNQVSVIErgAFQDLKQLERLRLNKNKLQVLPELLFQS------TPKLTRLDLS 78
Cdd:cd21340     53 LQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPPGEKLTFDPrslaalSNSLRVLNIS 128

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462603905   79 enqiqgiprkafrgitdvknlqldNNHISCIEDgaFRALRDLEILTLNNNNISRI--LVTSFNHMPKIRTLRLHSNHL 154
Cdd:cd21340    129 ------------------------GNNIDSLEP--LAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
712-772 1.66e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.09  E-value: 1.66e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462603905  712 RHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDI 772
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
96-154 5.77e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.16  E-value: 5.77e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462603905   96 VKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 154
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
248-304 9.40e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 9.40e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462603905  248 EIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKI 304
Cdd:pfam13855    5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 573-651 1.92e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 69.34  E-value: 1.92e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  573 LYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPR---CQKPFFLKEIPIQDVAIQDFTCD 649
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81


                   ..
gi 2462603905  650 GN 651
Cdd:TIGR00864   82 EE 83
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
459-727 8.65e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.56  E-value: 8.65e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  459 KLVRIPSHLPEYVTDLRLNDNEVsvleatgifKKLP-----NLRKINLSNNKIKEVREGAFDgaaSVQELMLTGNQLETV 533
Cdd:PRK15370   189 GLTTIPACIPEQITTLILDNNEL---------KSLPenlqgNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITEL 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  534 HGRVfrgLSGLKTLMLRSNLISCVSNDTFAGLssvRLLSLYDNRITTItPGAFTTlvSLSTINLLSNPfncnchLAWLGK 613
Cdd:PRK15370   257 PERL---PSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTL-PAHLPS--GITHLNVQSNS------LTALPE 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  614 WLrkrrivsgnprcqkPFFLKEIPIQDVAIqdfTCdgneesscqlsprCPEQCTCMETVVRCSNKGLRALPRGMPKDVTE 693
Cdd:PRK15370   322 TL--------------PPGLKTLEAGENAL---TS-------------LPASLPPELQVLDVSKNQITVLPETLPPTITT 371

                          250       260       270
                   ....*....|....*....|....*....|....
gi 2462603905  694 LYLEGNHLTAVPRELSALrhLTLIDLSNNSISML 727
Cdd:PRK15370   372 LDVSRNALTNLPENLPAA--LQIMQASRNNLVRL 403
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 671-797 2.59e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 2.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  671 TVVRCSNKGLRALPR-GMPKDVTELYLEGNHLTAVPrELSALRHLTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLR 749
Cdd:cd21340      5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  750 CIpvhafNGL---------------------------------RSLRVLTLHGNDISSVpeGSFNDLTSLSHLALGTNPL 796
Cdd:cd21340     82 VV-----EGLenltnleelhienqrlppgekltfdprslaalsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154


                   .
gi 2462603905  797 H 797
Cdd:cd21340    155 S 155
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 767-852 4.19e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 61.64  E-value: 4.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  767 LHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK---AGYKEPGIARCSSPEPMADRLLLTTPTHRFQCk 843
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC- 80


                   ....*....
gi 2462603905  844 gpvDINIVA 852
Cdd:TIGR00864   81 ---DEEYVA 86
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1011-1047 1.47e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.47e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462603905 1011 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFSGPFCE 1047
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
794-843 3.84e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.20  E-value: 3.84e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2462603905   794 NPLHCDCSLRWLSEWVKAG--YKEPGIARCSSPEPMADRlLLTTPTHRFQCK 843
Cdd:smart00082    1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
192-473 1.07e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 1.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  192 DVQKKEYVCPAPHSEPPScNANSISCPSPCTCSNNIVDCRGK-GLMEIPANLPEGIVEIRLEQNSIKAIPAGAftqYKKL 270
Cdd:PRK15370   147 ELIWSEWVKEAPAKEAAN-REEAVQRMRDCLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKSLPENL---QGNI 222

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  271 KRIDISKNQISDIA---PDAFQGLKsltslvLYGNKITEIAKGLfdgLVSLQLLLLNANKINCLRVNTFQDLQNlnlLSL 347
Cdd:PRK15370   223 KTLYANSNQLTSIPatlPDTIQEME------LSINRITELPERL---PSALQSLDLFHNKISCLPENLPEELRY---LSV 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  348 YDNKLQTISKGLfaPlQSIQTLHLAQN-----PFVCDCHLKWL-ADylqDNPIETSGArcSSPRRLANKRISQ----IKS 417
Cdd:PRK15370   291 YDNSIRTLPAHL--P-SGITHLNVQSNsltalPETLPPGLKTLeAG---ENALTSLPA--SLPPELQVLDVSKnqitVLP 362

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462603905  418 KKFRCSGSEDYRSRfssECFMDLvcPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTD 473
Cdd:PRK15370   363 ETLPPTITTLDVSR---NALTNL--PENLPAALQIMQASRNNLVRLPESLPHFRGE 413
EGF_CA smart00179
Calcium-binding EGF-like domain;
1011-1047 2.47e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.47e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2462603905  1011 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFS-GPFCE 1047
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 935-968 4.88e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462603905  935 DDCED-NDCENNATCVDGINNYVCICPPNYTGELC 968
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 347-410 1.97e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.70  E-value: 1.97e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462603905  347 LYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET---SGARCSSPRRLANK 410
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 937-966 2.85e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 2.85e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462603905  937 CEDNDCENNATCVDGINNYVCICPPNYTGE 966
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1060-1090 3.17e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.17e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2462603905 1060 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1090
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 893-931 3.38e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462603905  893 INTC-IQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQRCE 931
Cdd:cd00054      2 IDECaSGNPCQNGGTCV---NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1015-1045 3.50e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.50e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2462603905 1015 CVAHKCRHGAQCVDTINGYTCTCPQGFSGPF 1045
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 972-1009 4.07e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.07e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462603905  972 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 1009
Cdd:cd00054      2 IDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
600-649 6.64e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 41.65  E-value: 6.64e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2462603905   600 NPFNCNCHLAWLGKWLRKRRIVSG--NPRCQKPFFLKEiPIQDVAIQDFTCD 649
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRG-PLLELLHSEFKCP 51
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 125-187 9.20e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.38  E-value: 9.20e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462603905  125 LNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR--RTVG-QFTLCMAPVHLRG 187
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvKVRQpEAALCAGPGALAG 67
EGF_CA smart00179
Calcium-binding EGF-like domain;
935-964 1.70e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.70e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2462603905   935 DDCE-DNDCENNATCVDGINNYVCICPPNYT 964
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 1403-1458 3.32e-04

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 40.85  E-value: 3.32e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462603905  1403 SCATASKVPIMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLA 1458
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 2-117 4.82e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 4.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905    2 MGDLDRNNITRITKmDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQ-VLPELL--------------- 65
Cdd:PLN00113   456 MLSLARNKFFGGLP-DSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELssckklvsldlshnq 534

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462603905   66 --------FQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHI--SCIEDGAFRAL 117
Cdd:PLN00113   535 lsgqipasFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLhgSLPSTGAFLAI 596
LRRCT smart00082
Leucine rich repeat C-terminal domain;
374-404 6.20e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.95  E-value: 6.20e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2462603905   374 NPFVCDCHLKWLADYLQDNPI--ETSGARCSSP 404
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
972-1009 6.74e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 6.74e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2462603905   972 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYS-GKLCE 1009
Cdd:smart00179    2 IDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
LRRNT smart00013
Leucine rich repeat N-terminal domain;
217-248 1.24e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.68  E-value: 1.24e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462603905   217 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVE 248
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 217-243 1.47e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 1.47e-03
                           10        20
                   ....*....|....*....|....*..
gi 2462603905  217 CPSPCTCSNNIVDCRGKGLMEIPANLP 243
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1309-1337 2.74e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.74e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462603905 1309 CLGHRCHH-GKCVATGTSYMCKCAEGYGGD 1337
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGK 30
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 5-352 3.05e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 3.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905    5 LDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQ-VLPELLFqSTPKLTRLDLSENQIQ 83
Cdd:PLN00113   219 LGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLS 297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905   84 G-IPRKafrgITDVKNLQ---LDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL----- 154
Cdd:PLN00113   298 GeIPEL----VIQLQNLEilhLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLtgeip 373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  155 --YCDC-HLawlsdwlrqrrtvgqFTLCMAPVHLRGfnvaDVQKKEYVCPAPHSEPPSCNANSISCPSPCT--------- 222
Cdd:PLN00113   374 egLCSSgNL---------------FKLILFSNSLEG----EIPKSLGACRSLRRVRLQDNSFSGELPSEFTklplvyfld 434

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  223 -CSNNIVDCRGKGLMEIPAnlpegIVEIRLEQNSIKA-IPAgaFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLY 300
Cdd:PLN00113   435 iSNNNLQGRINSRKWDMPS-----LQMLSLARNKFFGgLPD--SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLS 507

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462603905  301 GNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKL 352
Cdd:PLN00113   508 ENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 896-929 3.24e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 3.24e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462603905  896 CIQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQR 929
Cdd:pfam00008    1 CAPNPCSNGGTCV---DTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
899-931 4.64e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 4.64e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 2462603905   899 NPCQHGGTCHlsdSHKDGFSCSCPLGFE-GQRCE 931
Cdd:smart00179    9 NPCQNGGTCV---NTVGSYRCECPPGYTdGRNCE 39
LRR smart00370
Leucine-rich repeats, outliers;
70-92 6.80e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 6.80e-03
                            10        20
                    ....*....|....*....|...
gi 2462603905    70 PKLTRLDLSENQIQGIPRKAFRG 92
Cdd:smart00370    2 PNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1125-1251 1.32e-31

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 120.22  E-value: 1.32e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905 1125 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTPKSLGKL 1202
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2462603905 1203 QKQPAVGINSPLYLGGIPTStglsaLRQGTDRPLGGFHGCIHEVRINNE 1251
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPL-----LLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1118-1251 3.45e-30

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 116.67  E-value: 3.45e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  1118 NISLQVATDKDNGILLY---KGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKG 1194
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462603905  1195 TPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTdrplgGFHGCIHEVRINNE 1251
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTP-----GFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1096-1249 3.61e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 117.13  E-value: 3.61e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905 1096 TVNFVGkDSYVELA-SAKVRPQANISLQVATDKDNGILLYKGD---NDPLALELYQGHVRLVYDsLSSPPTTVYSVETVN 1171
Cdd:cd00110      1 GVSFSG-SSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYD-LGSGSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462603905 1172 DGQFHSVELVTLNQTLNLVVDKGTPKSLGKLQKQPAVGINSPLYLGGIPTSTGLSALRQGTdrplgGFHGCIHEVRIN 1249
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP-----GFVGCIRDLKVN 151
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-154 1.42e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.18  E-value: 1.42e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905    4 DLDRNNITRITKmDFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELLFQSTpKLTRLDLSENQIQ 83
Cdd:COG4886    119 DLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLT-NLKELDLSNNQIT 195

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462603905   84 GIPrKAFRGITDVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNISRIlvTSFNHMPKIRTLRLHSNHL 154
Cdd:COG4886    196 DLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
5-392 2.28e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.63  E-value: 2.28e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905    5 LDRNNITRITKMDFAGLKNLRVLHLEDNQvsviergAFQDLKQLERLRLNKNKLQVLPELLFQSTpKLTRLDLSENQIQG 84
Cdd:COG4886     79 LLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELANLT-NLKELDLSNNQLTD 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905   85 IPrKAFRGITDVKNLQLDNNHISCIeDGAFRALRDLEILTLNNNNISRILvTSFNHMPKIRTLRLHSNHLYcdchlawls 164
Cdd:COG4886    151 LP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLT--------- 218

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  165 dwlrqrrtvgqftlcmapvhlrgfnvadvqkkeyvcpaphseppscnansiscpspctcsnnivdcrgkglmEIPANLPE 244
Cdd:COG4886    219 ------------------------------------------------------------------------DLPEPLAN 226

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  245 --GIVEIRLEQNSIKAIPagAFTQYKKLKRIDISKNQISDIAPDAfqGLKSLTSLVLYGNKITEIA-KGLFDGLVSLQLL 321
Cdd:COG4886    227 ltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKlKELELLLGLNSLL 302

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462603905  322 LLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDN 392
Cdd:COG4886    303 LLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
472-774 2.17e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 2.17e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  472 TDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKikevregAFDGAASVQELMLTGNQLETVhGRVFRGLSGLKTLMLRS 551
Cdd:COG4886     74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSN 145

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  552 NLISCVSnDTFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLLSNPfncnchlawlgkwlrkrrivsgnprcqkpf 631
Cdd:COG4886    146 NQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQ------------------------------ 193

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  632 fLKEIPiqdvaiqdftcdgneessCQLSprcpeqctcmetvvrcsnkGLRALprgmpkdvTELYLEGNHLTAVPRELSAL 711
Cdd:COG4886    194 -ITDLP------------------EPLG-------------------NLTNL--------EELDLSGNQLTDLPEPLANL 227

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462603905  712 RHLTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLRCIPVHAfnGLRSLRVLTLHGNDISS 774
Cdd:COG4886    228 TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
472-837 5.35e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 5.35e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  472 TDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLetvhgrvFRGLSGLKTLMLRS 551
Cdd:COG4886     50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSG 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  552 NLISCVSNDtFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLLSNPfncnchlawlgkwlrkrrivsgnprcqkpf 631
Cdd:COG4886    123 NQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQ------------------------------ 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  632 fLKEIPiqdvaiqdftcdgneesscqlsprcpeqctcmetvvrcsnKGLRALPRgmpkdVTELYLEGNHLTAVPRELSAL 711
Cdd:COG4886    171 -LTDLP----------------------------------------EELGNLTN-----LKELDLSNNQITDLPEPLGNL 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  712 RHLTLIDLSNNSISMLTNyTFSNMSHLSTLILSYNRLRCIPvhAFNGLRSLRVLTLHGNDISSVPEGSfnDLTSLSHLAL 791
Cdd:COG4886    205 TNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDL 279

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 2462603905  792 GTNPLHcDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 837
Cdd:COG4886    280 SNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
17-387 6.25e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 6.25e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905   17 DFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELLFQSTpKLTRLDLSENQIQGIPrKAFRGITDV 96
Cdd:COG4886    108 ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLSNNQLTDLP-EELGNLTNL 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905   97 KNLQLDNNHISCIEDgAFRALRDLEILTLNNNNISRiLVTSFNHMPKIRTLRLHSNHLYcdcHLAWLsdwlrqrrtvgqf 176
Cdd:COG4886    185 KELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQLT---DLPEL------------- 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  177 tlcmapvhlrgfnvadvqkkeyvcpaphseppscnansiscpspctcsnnivdcrgkglmeipANLPEgIVEIRLEQNSI 256
Cdd:COG4886    247 ---------------------------------------------------------------GNLTN-LEELDLSNNQL 262

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  257 KAIPAGAftQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAkgLFDGLVSLQLLLLNANKINCLRVNTF 336
Cdd:COG4886    263 TDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLE--LLILLLLLTTLLLLLLLLKGLLVTLT 338

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2462603905  337 QDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLAD 387
Cdd:COG4886    339 TLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTL 389
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
570-796 3.73e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.00  E-value: 3.73e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  570 LLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQkpfFLKEIPIQDVAIQDFTCD 649
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDL---LLSSLLLLLSLLLLLLLS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  650 GNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALprgmpKDVTELYLEGNHLTAVPRELSALRHLTLIDLSNNSISMLTN 729
Cdd:COG4886     79 LLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE 153

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462603905  730 yTFSNMSHLSTLILSYNRLRCIPvHAFNGLRSLRVLTLHGNDISSVPEgSFNDLTSLSHLALGTNPL 796
Cdd:COG4886    154 -PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQL 217
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
263-603 7.54e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 7.54e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  263 AFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKITEIAKGLFDglvslqllllnankinclrvntfqdLQNL 342
Cdd:COG4886    108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGN-------------------------LTNL 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  343 NLLSLYDNKLQTISKGLfAPLQsiqtlhlaqnpfvcdcHLKWLadYLQDNPIETSGARCSSPRRLankrisqikskkfrc 422
Cdd:COG4886    162 KSLDLSNNQLTDLPEEL-GNLT----------------NLKEL--DLSNNQITDLPEPLGNLTNL--------------- 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  423 sgsedyrsrfssecfmdlvcpekcrcegTIVDCSNQKLVRIPSHLPEY--VTDLRLNDNEVSVLEAtgiFKKLPNLRKIN 500
Cdd:COG4886    208 ----------------------------EELDLSGNQLTDLPEPLANLtnLETLDLSNNQLTDLPE---LGNLTNLEELD 256

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  501 LSNNKIKEVREGAfdGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITT 580
Cdd:COG4886    257 LSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                          330       340
                   ....*....|....*....|...
gi 2462603905  581 ITPGAFTTLVSLSTINLLSNPFN 603
Cdd:COG4886    335 VTLTTLALSLSLLALLTLLLLLN 357
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
227-396 8.95e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 8.95e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  227 IVDCRGKGLMEIPANLPE--GIVEIRLEQNSIKAIPAgAFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKI 304
Cdd:COG4886    117 SLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  305 TEIAKGLfdglvslqllllnankinclrvntfQDLQNLNLLSLYDNKLQTISKGLfAPLQSIQTLHLAQN-----PFVCD 379
Cdd:COG4886    195 TDLPEPL-------------------------GNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNqltdlPELGN 248

                          170
                   ....*....|....*...
gi 2462603905  380 C-HLKWLadYLQDNPIET 396
Cdd:COG4886    249 LtNLEEL--DLSNNQLTD 264
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-154 1.95e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.61  E-value: 1.95e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905    4 DLDRNNITRITKmDFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELlfQSTPKLTRLDLSENQIQ 83
Cdd:COG4886    188 DLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLT 263

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462603905   84 GIPrkAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 154
Cdd:COG4886    264 DLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332
Laminin_G_1 pfam00054
Laminin G domain;
1123-1254 7.63e-18

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 81.21  E-value: 7.63e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905 1123 VATDKDNGILLYKGDNDP---LALELYQGHVRLVYDsLSSPPTTVYSVETVNDGQFHSVELVTLNQTLNLVVDKGTP--- 1196
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErdfLALELRDGRLEVSYD-LGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARptg 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462603905 1197 -KSLGKLQKQPAVGinsPLYLGGIPTSTglSALRQGTDRPlgGFHGCIHEVRINNELQD 1254
Cdd:pfam00054   80 eSPLGATTDLDVDG---PLYVGGLPSLG--VKKRRLAISP--SFDGCIRDVIVNGKPLD 131
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-419 1.53e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 1.53e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905   44 DLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENqiqgiprKAFRGITDVKNLQLDNNHISCIEDgAFRALRDLEIL 123
Cdd:COG4886     70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKEL 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  124 TLNNNNISRIlVTSFNHMPKIRTLRLHSNhlycdchlawlsdwlrqrrtvgqftlcmapvhlrgfnvadvqkkeyvcpap 203
Cdd:COG4886    142 DLSNNQLTDL-PEPLGNLTNLKSLDLSNN--------------------------------------------------- 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  204 hseppscnansiscpspctcsnnivdcrgkGLMEIP---ANLPEgIVEIRLEQNSIKAIPAgAFTQYKKLKRIDISKNQI 280
Cdd:COG4886    170 ------------------------------QLTDLPeelGNLTN-LKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQL 217

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  281 SDIaPDAFQGLKSLTSLVLYGNKITEIAKglfdglvslqllllnankinclrvntFQDLQNLNLLSLYDNKLQTISKglF 360
Cdd:COG4886    218 TDL-PEPLANLTNLETLDLSNNQLTDLPE--------------------------LGNLTNLEELDLSNNQLTDLPP--L 268

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462603905  361 APLQSIQTLHLAQNPFVcDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKK 419
Cdd:COG4886    269 ANLTNLKTLDLSNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
273-602 5.93e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 5.93e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  273 IDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKL 352
Cdd:COG4886     46 LLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQL 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  353 QTISKGLfAPLQSIQTLHLAQNpfvcdchlkwladylqdnpietsgarcssprrlankRISQIKSkkfrcsgsedyrsrf 432
Cdd:COG4886    126 TDLPEEL-ANLTNLKELDLSNN------------------------------------QLTDLPE--------------- 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  433 ssecfmdlvcpekcrcegTIVDCSNqklvripshlpeyVTDLRLNDNEVSVLEATgiFKKLPNLRKINLSNNKIKEVREg 512
Cdd:COG4886    154 ------------------PLGNLTN-------------LKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQITDLPE- 199

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  513 AFDGAASVQELMLTGNQLETVhGRVFRGLSGLKTLMLRSNLISCVSNdtFAGLSSVRLLSLYDNRITTITPGAftTLVSL 592
Cdd:COG4886    200 PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNL 274

                          330
                   ....*....|
gi 2462603905  593 STINLLSNPF 602
Cdd:COG4886    275 KTLDLSNNQL 284
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 5-154 1.43e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 74.44  E-value: 1.43e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905    5 LDRNNITRITkmDFAGLKNLRVLHLEDNQVSVIErgAFQDLKQLERLRLNKNKLQVLPELLFQS------TPKLTRLDLS 78
Cdd:cd21340     53 LQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPPGEKLTFDPrslaalSNSLRVLNIS 128

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2462603905   79 enqiqgiprkafrgitdvknlqldNNHISCIEDgaFRALRDLEILTLNNNNISRI--LVTSFNHMPKIRTLRLHSNHL 154
Cdd:cd21340    129 ------------------------GNNIDSLEP--LAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
712-772 1.66e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.09  E-value: 1.66e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462603905  712 RHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDI 772
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
519-578 3.40e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 3.40e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  519 SVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRI 578
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
494-554 9.84e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 64.08  E-value: 9.84e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462603905  494 PNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLI 554
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
96-154 5.77e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.16  E-value: 5.77e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462603905   96 VKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 154
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
70-130 6.42e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 6.42e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462603905   70 PKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNI 130
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
248-304 9.40e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 9.40e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2462603905  248 EIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKI 304
Cdd:pfam13855    5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
542-602 1.27e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.00  E-value: 1.27e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462603905  542 SGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPF 602
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 573-651 1.92e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 69.34  E-value: 1.92e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  573 LYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPR---CQKPFFLKEIPIQDVAIQDFTCD 649
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81


                   ..
gi 2462603905  650 GN 651
Cdd:TIGR00864   82 EE 83
LRR_8 pfam13855
Leucine rich repeat;
736-796 2.43e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 2.43e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2462603905  736 SHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 796
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
23-82 2.45e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 2.45e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905   23 NLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQI 82
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
47-106 2.62e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.23  E-value: 2.62e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905   47 QLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHI 106
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
4-58 2.85e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 2.85e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2462603905    4 DLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKL 58
Cdd:pfam13855    7 DLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
471-530 3.23e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.15  E-value: 3.23e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  471 VTDLRLNDNEVSVLEAtGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQL 530
Cdd:pfam13855    3 LRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
691-748 7.73e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 7.73e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2462603905  691 VTELYLEGNHLTAVPRE-LSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRL 748
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
459-727 8.65e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.56  E-value: 8.65e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  459 KLVRIPSHLPEYVTDLRLNDNEVsvleatgifKKLP-----NLRKINLSNNKIKEVREGAFDgaaSVQELMLTGNQLETV 533
Cdd:PRK15370   189 GLTTIPACIPEQITTLILDNNEL---------KSLPenlqgNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITEL 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  534 HGRVfrgLSGLKTLMLRSNLISCVSNDTFAGLssvRLLSLYDNRITTItPGAFTTlvSLSTINLLSNPfncnchLAWLGK 613
Cdd:PRK15370   257 PERL---PSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTL-PAHLPS--GITHLNVQSNS------LTALPE 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  614 WLrkrrivsgnprcqkPFFLKEIPIQDVAIqdfTCdgneesscqlsprCPEQCTCMETVVRCSNKGLRALPRGMPKDVTE 693
Cdd:PRK15370   322 TL--------------PPGLKTLEAGENAL---TS-------------LPASLPPELQVLDVSKNQITVLPETLPPTITT 371

                          250       260       270
                   ....*....|....*....|....*....|....
gi 2462603905  694 LYLEGNHLTAVPRELSALrhLTLIDLSNNSISML 727
Cdd:PRK15370   372 LDVSRNALTNLPENLPAA--LQIMQASRNNLVRL 403
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 671-797 2.59e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.03  E-value: 2.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  671 TVVRCSNKGLRALPR-GMPKDVTELYLEGNHLTAVPrELSALRHLTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLR 749
Cdd:cd21340      5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  750 CIpvhafNGL---------------------------------RSLRVLTLHGNDISSVpeGSFNDLTSLSHLALGTNPL 796
Cdd:cd21340     82 VV-----EGLenltnleelhienqrlppgekltfdprslaalsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154


                   .
gi 2462603905  797 H 797
Cdd:cd21340    155 S 155
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 767-852 4.19e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 61.64  E-value: 4.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  767 LHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK---AGYKEPGIARCSSPEPMADRLLLTTPTHRFQCk 843
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC- 80


                   ....*....
gi 2462603905  844 gpvDINIVA 852
Cdd:TIGR00864   81 ---DEEYVA 86
PLN03150 PLN03150
hypothetical protein; Provisional
 704-797 8.32e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 60.21  E-value: 8.32e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  704 VPRELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLR-CIPvHAFNGLRSLRVLTLHGNDISS-VPEgsfn 781
Cdd:PLN03150   434 IPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIP-ESLGQLTSLRILNLNGNSLSGrVPA---- 508

                           90
                   ....*....|....*.
gi 2462603905  782 dltslshlALGTNPLH 797
Cdd:PLN03150   509 --------ALGGRLLH 516
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
634-796 1.07e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.10  E-value: 1.07e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  634 KEIPIQDVAIQDF-TCDGNEESSCQLS--------PRCPEQCTcmeTVVrCSNKGLRALPRGMPKDVTELYLEGNHLTAV 704
Cdd:PRK15370   160 KEAANREEAVQRMrDCLKNNKTELRLKilglttipACIPEQIT---TLI-LDNNELKSLPENLQGNIKTLYANSNQLTSI 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  705 PRELSALrhLTLIDLSNNSISMLTNYTfsnMSHLSTLILSYNRLRCIPVHAFNGLRSLRVltlHGNDISSVPEgsfNDLT 784
Cdd:PRK15370   236 PATLPDT--IQEMELSINRITELPERL---PSALQSLDLFHNKISCLPENLPEELRYLSV---YDNSIRTLPA---HLPS 304

                          170
                   ....*....|..
gi 2462603905  785 SLSHLALGTNPL 796
Cdd:PRK15370   305 GITHLNVQSNSL 316
LRR_8 pfam13855
Leucine rich repeat;
269-314 2.83e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 2.83e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 2462603905  269 KLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDG 314
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG 47
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 477-796 4.42e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 4.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  477 NDNEVSVLEATG---------IFKKLPNLRKINLSNNKIK-EVREGAFDGAASVQELMLTGNQLEtvhGRVFRG-LSGLK 545
Cdd:PLN00113    67 NSSRVVSIDLSGknisgkissAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFT---GSIPRGsIPNLE 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  546 TLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNC----------NCHLAWLG--- 612
Cdd:PLN00113   144 TLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGqiprelgqmkSLKWIYLGynn 223

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  613 ------------KWLRKRRIVSGNPRCQKP-----------FFLKE------IPIQDVAIQDF-TCDGNEESscqLSPRC 662
Cdd:PLN00113   224 lsgeipyeigglTSLNHLDLVYNNLTGPIPsslgnlknlqyLFLYQnklsgpIPPSIFSLQKLiSLDLSDNS---LSGEI 300

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  663 PE---QCTCMETVVRCSNK-------GLRALPRgmpkdVTELYLEGNHLTA-VPRELSALRHLTLIDLSNNSISMLTNYT 731
Cdd:PLN00113   301 PElviQLQNLEILHLFSNNftgkipvALTSLPR-----LQVLQLWSNKFSGeIPKNLGKHNNLTVLDLSTNNLTGEIPEG 375

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462603905  732 FSNMSHLSTLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 796
Cdd:PLN00113   376 LCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL 440
LRR_8 pfam13855
Leucine rich repeat;
324-376 7.92e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 7.92e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2462603905  324 NANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPF 376
Cdd:pfam13855    9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1011-1047 1.47e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 1.47e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462603905 1011 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFSGPFCE 1047
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
794-843 3.84e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.20  E-value: 3.84e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2462603905   794 NPLHCDCSLRWLSEWVKAG--YKEPGIARCSSPEPMADRlLLTTPTHRFQCK 843
Cdd:smart00082    1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
192-473 1.07e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 1.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  192 DVQKKEYVCPAPHSEPPScNANSISCPSPCTCSNNIVDCRGK-GLMEIPANLPEGIVEIRLEQNSIKAIPAGAftqYKKL 270
Cdd:PRK15370   147 ELIWSEWVKEAPAKEAAN-REEAVQRMRDCLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKSLPENL---QGNI 222

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  271 KRIDISKNQISDIA---PDAFQGLKsltslvLYGNKITEIAKGLfdgLVSLQLLLLNANKINCLRVNTFQDLQNlnlLSL 347
Cdd:PRK15370   223 KTLYANSNQLTSIPatlPDTIQEME------LSINRITELPERL---PSALQSLDLFHNKISCLPENLPEELRY---LSV 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  348 YDNKLQTISKGLfaPlQSIQTLHLAQN-----PFVCDCHLKWL-ADylqDNPIETSGArcSSPRRLANKRISQ----IKS 417
Cdd:PRK15370   291 YDNSIRTLPAHL--P-SGITHLNVQSNsltalPETLPPGLKTLeAG---ENALTSLPA--SLPPELQVLDVSKnqitVLP 362

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462603905  418 KKFRCSGSEDYRSRfssECFMDLvcPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTD 473
Cdd:PRK15370   363 ETLPPTITTLDVSR---NALTNL--PENLPAALQIMQASRNNLVRLPESLPHFRGE 413
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 24-157 1.88e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.59  E-value: 1.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905   24 LRVLHLEDNQVSV----IERGAFQDLK-QLERLRLNKNKLQVLP----ELLFQSTPKLTRLDLSENQI--QGIPR--KAF 90
Cdd:cd00116    110 LQELKLNNNGLGDrglrLLAKGLKDLPpALEKLVLGRNRLEGAScealAKALRANRDLKELNLANNGIgdAGIRAlaEGL 189

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462603905   91 RGITDVKNLQLDNNHISCIED----GAFRALRDLEILTLNNNNIS----RILVTSFNHM-PKIRTLRLHSNHLYCD 157
Cdd:cd00116    190 KANCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTdagaAALASALLSPnISLLTLSLSCNDITDD 265
EGF_CA smart00179
Calcium-binding EGF-like domain;
1011-1047 2.47e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.47e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2462603905  1011 DNDDCV-AHKCRHGAQCVDTINGYTCTCPQGFS-GPFCE 1047
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-140 3.11e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 3.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905    4 DLDRNNITRITkmDFAGLKNLRVLHLEDNQVSVIerGAFQDLKQLERLRLNKNK-----LQVLPELLFQSTPKLTRLDLS 78
Cdd:COG4886    234 DLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQltdlkLKELELLLGLNSLLLLLLLLN 309

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462603905   79 ENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNH 140
Cdd:COG4886    310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGL 371
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-603 4.10e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 4.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905   71 KLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISC-IEDGAFRALRDLEILTLNNNNISRILVTSFnhMPKIRTLRL 149
Cdd:PLN00113    70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDL 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  150 HSNHLYCDCHLawlsdwlrqrrTVGQFTlcmapvhlrGFNVADVQKKEYVCPAPHSEppscnANSISCPSPCTCSNNIVD 229
Cdd:PLN00113   148 SNNMLSGEIPN-----------DIGSFS---------SLKVLDLGGNVLVGKIPNSL-----TNLTSLEFLTLASNQLVG 202

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  230 crgkglmEIPANLPE--GIVEIRLEQNSIKAIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKIT-E 306
Cdd:PLN00113   203 -------QIPRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgP 275

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  307 IAKGLFDglvslqllllnankinclrvntfqdLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCdchlkwla 386
Cdd:PLN00113   276 IPPSIFS-------------------------LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTG-------- 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  387 dylqdnpiETSGARCSSPRRlankRISQIKSKKFRCSGSEDYRSRfSSECFMDLvcpEKCRCEGTIVD--CSNQKLVR-- 462
Cdd:PLN00113   323 --------KIPVALTSLPRL----QVLQLWSNKFSGEIPKNLGKH-NNLTVLDL---STNNLTGEIPEglCSSGNLFKli 386

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  463 -----IPSHLPEYVTD------LRLNDNEVSVlEATGIFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLE 531
Cdd:PLN00113   387 lfsnsLEGEIPKSLGAcrslrrVRLQDNSFSG-ELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFF 465

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462603905  532 TVHGRVFRGlSGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFN 603
Cdd:PLN00113   466 GGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 935-968 4.88e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2462603905  935 DDCED-NDCENNATCVDGINNYVCICPPNYTGELC 968
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 692-776 1.53e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 1.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  692 TELYLE------GNHLTAVPRELSALRH-LTLIDLSNNSISMLTNytFSNMSHLSTLILSYNRLRCIP--VHAFNGLRSL 762
Cdd:cd21340     93 EELHIEnqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSL 170

                           90
                   ....*....|....
gi 2462603905  763 RVLTLHGNDISSVP 776
Cdd:cd21340    171 RELDLTGNPVCKKP 184
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 347-410 1.97e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.70  E-value: 1.97e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462603905  347 LYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET---SGARCSSPRRLANK 410
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 937-966 2.85e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 2.85e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462603905  937 CEDNDCENNATCVDGINNYVCICPPNYTGE 966
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1060-1090 3.17e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.17e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2462603905 1060 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1090
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 893-931 3.38e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2462603905  893 INTC-IQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQRCE 931
Cdd:cd00054      2 IDECaSGNPCQNGGTCV---NTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1015-1045 3.50e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.50e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2462603905 1015 CVAHKCRHGAQCVDTINGYTCTCPQGFSGPF 1045
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 972-1009 4.07e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.07e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2462603905  972 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYSGKLCE 1009
Cdd:cd00054      2 IDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
600-649 6.64e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 41.65  E-value: 6.64e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2462603905   600 NPFNCNCHLAWLGKWLRKRRIVSG--NPRCQKPFFLKEiPIQDVAIQDFTCD 649
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRG-PLLELLHSEFKCP 51
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 125-187 9.20e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.38  E-value: 9.20e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462603905  125 LNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR--RTVG-QFTLCMAPVHLRG 187
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvKVRQpEAALCAGPGALAG 67
LRRNT smart00013
Leucine rich repeat N-terminal domain;
662-693 1.20e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 1.20e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462603905   662 CPEQCTCMETVVRCSNKGLRALPRGMPKDVTE 693
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1018-1047 1.51e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 40.54  E-value: 1.51e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2462603905 1018 HKCRHGAQCVDTINGYTCTCPQGFSGPF-CE 1047
Cdd:cd00053      6 NPCSNGGTCVNTPGSYRCVCPPGYTGDRsCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
935-964 1.70e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 1.70e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2462603905   935 DDCE-DNDCENNATCVDGINNYVCICPPNYT 964
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 1101-1248 2.05e-04

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 43.14  E-value: 2.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905 1101 GKDSYVELASAKVRPQAN-ISLQVATDKDNG---ILLYKGDNDPLALELYQ-GHVRLVYDSLSSPPTTVYSVETVNDGQF 1175
Cdd:pfam13385    2 GGSDYVTLPDALLPTSDFtVSAWVKPDSLPGwarAIISSSGGGGYSLGLDGdGRLRFAVNGGNGGWDTVTSGASVPLGQW 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2462603905 1176 HSVeLVTLN-QTLNLVVDkGTPKSLGKLQKQPAVGINSPLYLGGiptstglsalRQGTDRPlggFHGCIHEVRI 1248
Cdd:pfam13385   82 THV-AVTYDgGTLRLYVN-GVLVGSSTLTGGPPPGTGGPLYIGR----------SPGGDDY---FNGLIDEVRI 140
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1020-1041 2.26e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 39.62  E-value: 2.26e-04
                           10        20
                   ....*....|....*....|..
gi 2462603905 1020 CRHGAQCVDTINGYTCTCPQGF 1041
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 21-152 3.10e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.65  E-value: 3.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905   21 LKNLRVLHLEDNQVSVIE----RGAFQDLKQLERLRLNKNKLQVLPELL------FQSTPKLTRLDLSEN--QIQGIPR- 87
Cdd:cd00116     22 LLCLQVLRLEGNTLGEEAakalASALRPQPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNalGPDGCGVl 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905   88 KAFRGITDVKNLQLDNN--------------------------------HISCIE-DGAFRALRDLEILTLNNNNIS--- 131
Cdd:cd00116    102 ESLLRSSSLQELKLNNNglgdrglrllakglkdlppaleklvlgrnrleGASCEAlAKALRANRDLKELNLANNGIGdag 181

                          170       180
                   ....*....|....*....|..
gi 2462603905  132 -RILVTSFNHMPKIRTLRLHSN 152
Cdd:cd00116    182 iRALAEGLKANCNLEVLDLNNN 203
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 1403-1458 3.32e-04

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 40.85  E-value: 3.32e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2462603905  1403 SCATASKVPIMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGCLA 1458
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEP 79
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 472-630 4.71e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 4.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  472 TDLRLNDNEVSVLEAtgiFKKLPNLRKINLSNNKIKEVrEGaFDGAASVQELMLtGNQletvhgRVFRGLSglktLMLRS 551
Cdd:cd21340     49 THLYLQNNQIEKIEN---LENLVNLKKLYLGGNRISVV-EG-LENLTNLEELHI-ENQ------RLPPGEK----LTFDP 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  552 NLISCVSNdtfaglsSVRLLSLYDNRITTITPgaFTTLVSLSTINLLSNPFNCNCHLAW-LGKWLRKRRI-VSGNPRCQK 629
Cdd:cd21340    113 RSLAALSN-------SLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELLDlLSSWPSLRELdLTGNPVCKK 183


                   .
gi 2462603905  630 P 630
Cdd:cd21340    184 P 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 2-117 4.82e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 4.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905    2 MGDLDRNNITRITKmDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQ-VLPELL--------------- 65
Cdd:PLN00113   456 MLSLARNKFFGGLP-DSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELssckklvsldlshnq 534

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2462603905   66 --------FQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHI--SCIEDGAFRAL 117
Cdd:PLN00113   535 lsgqipasFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLhgSLPSTGAFLAI 596
LRRCT smart00082
Leucine rich repeat C-terminal domain;
374-404 6.20e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.95  E-value: 6.20e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 2462603905   374 NPFVCDCHLKWLADYLQDNPI--ETSGARCSSP 404
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 22-154 6.62e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.01  E-value: 6.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905   22 KNLRVLHLEDNQVSviERGA------FQDLKQLERLRLNKNK-----LQVLPELLfQSTPKLTRLDLSENQI--QGIPR- 87
Cdd:COG5238    208 TTVTTLWLKRNPIG--DEGAeilaeaLKGNKSLTTLDLSNNQigdegVIALAEAL-KNNTTVETLYLSGNQIgaEGAIAl 284

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2462603905   88 -KAFRGITDVKNLQLDNNHISciEDGAfRALRD-------LEILTLNNNNIS----RILVTSFNHMPKIRTLRLHSNHL 154
Cdd:COG5238    285 aKALQGNTTLTSLDLSVNRIG--DEGA-IALAEglqgnktLHTLNLAYNGIGaqgaIALAKALQENTTLHSLDLSDNQI 360
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 268-307 6.67e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.77  E-value: 6.67e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 2462603905  268 KKLKRIDISKNQISDIapDAFQGLKSLTSLVLYGN-KITEI 307
Cdd:pfam12799    1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDL 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
972-1009 6.74e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 6.74e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2462603905   972 IDHCVpELNLCQHEAKCIPLDKGFSCECVPGYS-GKLCE 1009
Cdd:smart00179    2 IDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 261-393 7.33e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 7.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  261 AGAFTQYKKLKRIDISKNQISD-----IApDAFQGLKSLTSLVLYGNKITE-----IAKGLfDGLVSLQLLLLNANKI-- 328
Cdd:COG5238    229 AEALKGNKSLTTLDLSNNQIGDegviaLA-EALKNNTTVETLYLSGNQIGAegaiaLAKAL-QGNTTLTSLDLSVNRIgd 306

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2462603905  329 -------NCLRVNtfqdlQNLNLLSLYDNKLQTI-SKGLFAPLQ---SIQTLHLAQNPfVCDCHLKWLADYLQDNP 393
Cdd:COG5238    307 egaialaEGLQGN-----KTLHTLNLAYNGIGAQgAIALAKALQentTLHSLDLSDNQ-IGDEGAIALAKYLEGNT 376
LRRNT smart00013
Leucine rich repeat N-terminal domain;
217-248 1.24e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.68  E-value: 1.24e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2462603905   217 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVE 248
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 217-243 1.47e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 1.47e-03
                           10        20
                   ....*....|....*....|....*..
gi 2462603905  217 CPSPCTCSNNIVDCRGKGLMEIPANLP 243
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRNT smart00013
Leucine rich repeat N-terminal domain;
442-472 1.75e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 37.30  E-value: 1.75e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 2462603905   442 CPEKCRCEGTIVDCSNQKLVRIPSHLPEYVT 472
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 938-966 2.20e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 2.20e-03
                           10        20
                   ....*....|....*....|....*....
gi 2462603905  938 EDNDCENNATCVDGINNYVCICPPNYTGE 966
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 662-688 2.29e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.84  E-value: 2.29e-03
                           10        20
                   ....*....|....*....|....*..
gi 2462603905  662 CPEQCTCMETVVRCSNKGLRALPRGMP 688
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
493-516 2.60e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 2.60e-03
                            10        20
                    ....*....|....*....|....
gi 2462603905   493 LPNLRKINLSNNKIKEVREGAFDG 516
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR smart00370
Leucine-rich repeats, outliers;
493-516 2.60e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.56  E-value: 2.60e-03
                            10        20
                    ....*....|....*....|....
gi 2462603905   493 LPNLRKINLSNNKIKEVREGAFDG 516
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 942-961 2.63e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.54  E-value: 2.63e-03
                           10        20
                   ....*....|....*....|
gi 2462603905  942 CENNATCVDGINNYVCICPP 961
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPP 20
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1008-1043 2.72e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 36.81  E-value: 2.72e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2462603905 1008 CETDNDDCVAHkcrhgAQCVDTINGYTCTCPQGFSG 1043
Cdd:pfam12947    1 CSDNNGGCHPN-----ATCTNTGGSFTCTCNDGYTG 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1309-1337 2.74e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.74e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 2462603905 1309 CLGHRCHH-GKCVATGTSYMCKCAEGYGGD 1337
Cdd:pfam00008    1 CAPNPCSNgGTCVDTPGGYTCICPEGYTGK 30
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 5-352 3.05e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 3.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905    5 LDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQ-VLPELLFqSTPKLTRLDLSENQIQ 83
Cdd:PLN00113   219 LGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLDLSDNSLS 297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905   84 G-IPRKafrgITDVKNLQ---LDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL----- 154
Cdd:PLN00113   298 GeIPEL----VIQLQNLEilhLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLtgeip 373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  155 --YCDC-HLawlsdwlrqrrtvgqFTLCMAPVHLRGfnvaDVQKKEYVCPAPHSEPPSCNANSISCPSPCT--------- 222
Cdd:PLN00113   374 egLCSSgNL---------------FKLILFSNSLEG----EIPKSLGACRSLRRVRLQDNSFSGELPSEFTklplvyfld 434

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  223 -CSNNIVDCRGKGLMEIPAnlpegIVEIRLEQNSIKA-IPAgaFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLY 300
Cdd:PLN00113   435 iSNNNLQGRINSRKWDMPS-----LQMLSLARNKFFGgLPD--SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLS 507

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2462603905  301 GNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKL 352
Cdd:PLN00113   508 ENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 4-155 3.10e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.14  E-value: 3.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905    4 DLDRNNIT-RITKMDFAgLKNLRVLHLEDNQVSvierGAFQDL---KQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSE 79
Cdd:PLN00113   434 DISNNNLQgRINSRKWD-MPSLQMLSLARNKFF----GGLPDSfgsKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSE 508

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2462603905   80 NQIQG-IPRKaFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLY 155
Cdd:PLN00113   509 NKLSGeIPDE-LSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLH 584
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 896-929 3.24e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 3.24e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2462603905  896 CIQNPCQHGGTCHlsdSHKDGFSCSCPLGFEGQR 929
Cdd:pfam00008    1 CAPNPCSNGGTCV---DTPGGYTCICPEGYTGKR 31
LRR_9 pfam14580
Leucine-rich repeat;
476-559 3.92e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.75  E-value: 3.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  476 LNDNEVSVLEAtgiFKKLPNLRKINLSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGrvFRGLSGLKTLMLRSNLIS 555
Cdd:pfam14580   49 FSDNEIRKLDG---FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGD--LDPLASLKKLTFLSLLRN 123


                   ....
gi 2462603905  556 CVSN 559
Cdd:pfam14580  124 PVTN 127
EGF_CA smart00179
Calcium-binding EGF-like domain;
899-931 4.64e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 4.64e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 2462603905   899 NPCQHGGTCHlsdSHKDGFSCSCPLGFE-GQRCE 931
Cdd:smart00179    9 NPCQNGGTCV---NTVGSYRCECPPGYTdGRNCE 39
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 8-114 4.69e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 38.68  E-value: 4.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905    8 NNITRITKMDFAGLKNLRVLHLEDNqVSVIERGAFQDLKqLERLRLNKNkLQVLPELLFQSTPKLTRLDLSENqIQGIPR 87
Cdd:pfam13306   20 SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNCS-LTSITIPSS-LTSIGEYAFSNCSNLKSITLPSN-LTSIGS 95

                           90       100
                   ....*....|....*....|....*..
gi 2462603905   88 KAFRGiTDVKNLQLDNNHIScIEDGAF 114
Cdd:pfam13306   96 YAFSN-CSLKSITIPSSVTT-IGSYAF 120
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 474-806 6.42e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 6.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  474 LRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEvregafdGAASVQELMLTGNQ-LETVHgrvfrgLSGLKTLMLRSN 552
Cdd:cd00116      3 LSLKGELLKTERATELLPKLLCLQVLRLEGNTLGE-------EAAKALASALRPQPsLKELC------LSLNETGRIPRG 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  553 LISCvsndtfaglssvrllslydnrittitPGAFTTLVSLSTINLLSNPFNC-NCHLAwlgkwlrkrrivsgnPRCQKPF 631
Cdd:cd00116     70 LQSL--------------------------LQGLTKGCGLQELDLSDNALGPdGCGVL---------------ESLLRSS 108

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  632 FLKEIPIQDVAIQDftcdgneesscqlsprcpeqctcmeTVVRCSNKGLRALPrgmpKDVTELYLEGNHLTAVPRE---- 707
Cdd:cd00116    109 SLQELKLNNNGLGD-------------------------RGLRLLAKGLKDLP----PALEKLVLGRNRLEGASCEalak 159

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462603905  708 -LSALRHLTLIDLSNNSISM-LTNYTFSNM---SHLSTLILSYNRLRCIPV----HAFNGLRSLRVLTLHGNDISSVP-- 776
Cdd:cd00116    160 aLRANRDLKELNLANNGIGDaGIRALAEGLkanCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTDAGaa 239

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 2462603905  777 ---EGSFNDLTSLSHLALGTNPLHCD------------CSLRWLS 806
Cdd:cd00116    240 alaSALLSPNISLLTLSLSCNDITDDgakdlaevlaekESLLELD 284
LRR smart00370
Leucine-rich repeats, outliers;
70-92 6.80e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 6.80e-03
                            10        20
                    ....*....|....*....|...
gi 2462603905    70 PKLTRLDLSENQIQGIPRKAFRG 92
Cdd:smart00370    2 PNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
70-92 6.80e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 6.80e-03
                            10        20
                    ....*....|....*....|...
gi 2462603905    70 PKLTRLDLSENQIQGIPRKAFRG 92
Cdd:smart00369    2 PNLRELDLSNNQLSSLPPGAFQG 24
LRR smart00370
Leucine-rich repeats, outliers;
759-782 7.43e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 7.43e-03
                            10        20
                    ....*....|....*....|....
gi 2462603905   759 LRSLRVLTLHGNDISSVPEGSFND 782
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
759-782 7.43e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 7.43e-03
                            10        20
                    ....*....|....*....|....
gi 2462603905   759 LRSLRVLTLHGNDISSVPEGSFND 782
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 22-58 9.92e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 9.92e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2462603905   22 KNLRVLHLEDNQVSVIErgAFQDLKQLERLRLNKNKL 58
Cdd:pfam12799    1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNK 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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