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Conserved domains on  [gi|2462604063|ref|XP_054209309|]
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transcription factor 7 isoform X18 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CTNNB1_binding super family cl07093
N-terminal CTNNB1 binding; This region tends to appear at the N-terminus of proteins also ...
18-184 9.81e-20

N-terminal CTNNB1 binding; This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (pfam00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation.


The actual alignment was detected with superfamily member pfam08347:

Pssm-ID: 462440  Cd Length: 207  Bit Score: 83.36  E-value: 9.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604063  18 GAPDELLAFQDEGeEQDDKSrDSAAGPERDLAELKSSLVNESEgaaggagipGVPGAGAGARGEAEALGREHAAQRLFPD 97
Cdd:pfam08347   9 GANDEMISFKDEG-EQEEKI-AENASAERDLADIKSSLVNESE---------SSPSSSSDSEAEHEAARRKQRSQRSYQD 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604063  98 KLPEPLEDGLKAPectsGMYKETVYSAFNLLM----HYPPPSGAGQHPQPQPPLVSGPRSQCRPVLAAS-----LTSTRP 168
Cdd:pfam08347  78 KLRRRQDDGKKVP----GMFKGPPYPGYPFLMipdlGSPYLPNGSLSPGARTPLPPAHLSNKVPVVQPShhvhpLTPLIT 153
                         170
                  ....*....|....*.
gi 2462604063 169 ISPPTVSPNSLSTNIS 184
Cdd:pfam08347 154 YSNEHFSPGSHPPHLS 169
 
Name Accession Description Interval E-value
CTNNB1_binding pfam08347
N-terminal CTNNB1 binding; This region tends to appear at the N-terminus of proteins also ...
18-184 9.81e-20

N-terminal CTNNB1 binding; This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (pfam00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation.


Pssm-ID: 462440  Cd Length: 207  Bit Score: 83.36  E-value: 9.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604063  18 GAPDELLAFQDEGeEQDDKSrDSAAGPERDLAELKSSLVNESEgaaggagipGVPGAGAGARGEAEALGREHAAQRLFPD 97
Cdd:pfam08347   9 GANDEMISFKDEG-EQEEKI-AENASAERDLADIKSSLVNESE---------SSPSSSSDSEAEHEAARRKQRSQRSYQD 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604063  98 KLPEPLEDGLKAPectsGMYKETVYSAFNLLM----HYPPPSGAGQHPQPQPPLVSGPRSQCRPVLAAS-----LTSTRP 168
Cdd:pfam08347  78 KLRRRQDDGKKVP----GMFKGPPYPGYPFLMipdlGSPYLPNGSLSPGARTPLPPAHLSNKVPVVQPShhvhpLTPLIT 153
                         170
                  ....*....|....*.
gi 2462604063 169 ISPPTVSPNSLSTNIS 184
Cdd:pfam08347 154 YSNEHFSPGSHPPHLS 169
 
Name Accession Description Interval E-value
CTNNB1_binding pfam08347
N-terminal CTNNB1 binding; This region tends to appear at the N-terminus of proteins also ...
18-184 9.81e-20

N-terminal CTNNB1 binding; This region tends to appear at the N-terminus of proteins also containing DNA-binding HMG (high mobility group) boxes (pfam00505) and appears to bind the armadillo repeat of CTNNB1 (beta-catenin), forming a stable complex. Signaling by Wnt through TCF/LCF is involved in developmental patterning, induction of neural tissues, cell fate decisions and stem cell differentiation. Isoforms of HMG T-cell factors lacking the N-terminal CTNNB1-binding domain cannot fulfill their role as transcriptional activators in T-cell differentiation.


Pssm-ID: 462440  Cd Length: 207  Bit Score: 83.36  E-value: 9.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604063  18 GAPDELLAFQDEGeEQDDKSrDSAAGPERDLAELKSSLVNESEgaaggagipGVPGAGAGARGEAEALGREHAAQRLFPD 97
Cdd:pfam08347   9 GANDEMISFKDEG-EQEEKI-AENASAERDLADIKSSLVNESE---------SSPSSSSDSEAEHEAARRKQRSQRSYQD 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462604063  98 KLPEPLEDGLKAPectsGMYKETVYSAFNLLM----HYPPPSGAGQHPQPQPPLVSGPRSQCRPVLAAS-----LTSTRP 168
Cdd:pfam08347  78 KLRRRQDDGKKVP----GMFKGPPYPGYPFLMipdlGSPYLPNGSLSPGARTPLPPAHLSNKVPVVQPShhvhpLTPLIT 153
                         170
                  ....*....|....*.
gi 2462604063 169 ISPPTVSPNSLSTNIS 184
Cdd:pfam08347 154 YSNEHFSPGSHPPHLS 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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