putative histone-lysine N-methyltransferase PRDM6 isoform X2 [Homo sapiens]
Protein Classification
SET domain-containing protein( domain architecture ID 1562517)
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| SET super family | cl40432 | SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ... |
247-303 | 3.76e-31 | ||
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site. The actual alignment was detected with superfamily member cd19191: Pssm-ID: 394802 Cd Length: 128 Bit Score: 113.34 E-value: 3.76e-31
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| Name | Accession | Description | Interval | E-value | ||
| PR-SET_PRDM6 | cd19191 | PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ... |
247-303 | 3.76e-31 | ||
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro. Pssm-ID: 380968 Cd Length: 128 Bit Score: 113.34 E-value: 3.76e-31
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| Name | Accession | Description | Interval | E-value | ||
| PR-SET_PRDM6 | cd19191 | PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ... |
247-303 | 3.76e-31 | ||
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro. Pssm-ID: 380968 Cd Length: 128 Bit Score: 113.34 E-value: 3.76e-31
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| PR-SET_PRDM-like | cd10534 | PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ... |
247-284 | 6.90e-08 | ||
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Pssm-ID: 380932 Cd Length: 83 Bit Score: 49.12 E-value: 6.90e-08
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| PR-SET_PRDM12 | cd19196 | PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ... |
247-303 | 5.80e-06 | ||
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation. Pssm-ID: 380973 [Multi-domain] Cd Length: 130 Bit Score: 45.04 E-value: 5.80e-06
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| PR-SET_ZFPM | cd19201 | PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ... |
240-284 | 1.60e-03 | ||
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Pssm-ID: 380978 Cd Length: 122 Bit Score: 37.71 E-value: 1.60e-03
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