|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
667-954 |
7.52e-152 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
:
Pssm-ID: 239227 Cd Length: 292 Bit Score: 456.65 E-value: 7.52e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 667 SINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSGST 746
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 747 WLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLGYRKYQPNI 826
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 827 DVQESIHFLESEFSrGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFWVS---SESKLSDSWQPRSLDIE 903
Cdd:cd02897 161 VVEKALSCLEAALD-SISDPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHWSRpppSEEGPSYYWQAPSAEVE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 2462606136 904 VAAYALLSHFLQ--FQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 954
Cdd:cd02897 240 MTAYALLALLSAggEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| YfaS super family |
cl34462 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
6-1009 |
2.13e-38 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
The actual alignment was detected with superfamily member COG2373:
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 157.16 E-value: 2.13e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 6 LNGTITAKYTYGKPVKG---DVTLTFLPLSFwgkkknitkTFKinGSANFSFNDEEMKN---VMDSSNG----------- 68
Cdd:COG2373 489 VTVTVDARYLFGAPAAGlkvEGEVTLRPART---------AFP--GYPGYRFGDPDEEFepeELDLGEGtldadgkasls 557
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 69 --LSEYLDLSSPGPVEILTTVTESvTG--ISRNVSTNVFFKQHdYI-IEFFDYTTVLKPSlNFTATVKVTRADGNQLTle 143
Cdd:COG2373 558 lpLPDAPDAPGPLRATVEASVFES-GGrpVTRSATVPVHPADF-YVgIRLPLFDGDPEGA-PATFEVVAVDPDGKPVA-- 632
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 144 erRNNVVITVTQRNYTEYWSGSNSGNQKMEAVQK------------------INYTVPQSGTFKIEfpiLEDSSELQL-- 203
Cdd:COG2373 633 --GKGLKVELYREEWRYVWYKSDDGGWRYESQEKeepvaegtlttgadgpasLSLTPVEWGRYRLE---VKDPDGGLAts 707
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 204 KAYFLGSKSSmavhslFKSPSKTYIQLKTRDENIKVG--------SPFE----LVVSGNKRLKElsymvvsrgQLVAVGK 271
Cdd:COG2373 708 VRFYAGGNAS------WGAERPDRLELSLDKESYKPGetaklliqSPFAgralVTVERDGVLET---------QWVDVKG 772
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 272 qNSTMFSLTPENSWTPKACVIVYYI--EDDGEIISD-----VLKIPVQLV-FKNKIKLywsKV--KAEPSEKVSLRISVT 341
Cdd:COG2373 773 -GGTTVEIPVTEDWAPNAYVSATLVrpGDSTANDMParaygVAPLPVDPPaRRLKVEL---TApeKLRPGETLTVTVKVK 848
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 342 QPD---SIVGIVAVDKSV-NLMNasnditmenvvhelelYNT----GYYlgmfmnsfavFQECGLWVLTDANLtkDYIDG 413
Cdd:COG2373 849 GAAgkaAEVTLAAVDEGIlNLTG----------------YKTpdplDFF----------YGKRALGVETRDLY--GRLIG 900
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 414 VYDNAEYAERF---MEENEGhivdihdfslGSSPHVRKHFPETWIW---LDTNMGSRIyqEFEVTVPDSITSWVATGFVI 487
Cdd:COG2373 901 AFGGAAGALRSggdGALGRG----------GNPKPPRKRFKPVALFsgpVKTDADGKA--TVSFDLPDFNGTLRVMAVAW 968
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 488 SED-LGLGLTTTPVElqafQPFFIFLNLPYSVIRGEEFALEITIFNYLKDATEVKVIIEKSDKFDILMTSSeinatghqQ 566
Cdd:COG2373 969 SDDrFGSAEATVTVR----KPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEGEAT--------Q 1036
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 567 TLLVPSEDGATVLFPIRPTHLGEIPITVTALSPTASDAITQMILVKAEGIEKSYSQSILLDltdnrlQSTLKTLSFSFPP 646
Cdd:COG2373 1037 TVTLAAGGRATVRFPLKAPDAGDAKVTVTATGGGESDAREVELPVRPANPLVTRATSGVLA------PGESWTLPLDLPG 1110
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 647 NTVTGSERVQI----TAIGDVLGpsinGLASLIRMPYGCGEQNMINFAPNIYILDyLTKKKQLTDNLKEKALSFMRQGYQ 722
Cdd:COG2373 1111 GLRPGTGSLTLslssSPPLDLAG----LLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIA 1185
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 723 RELLYQREDGSFSAFGNYDPSgSTWLSAFVLRCFLEADPY-IDIDQNVLHRTYTWLKGHQKSNGEFwdpgrvihsELQGG 801
Cdd:COG2373 1186 RLLSMQNSDGGFGLWPGGSES-DPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPWEI---------EYDDA 1255
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 802 NKSPVTLTAYIVTSLLGyrkyQPNIDVQESIHFLESEFsrgiSDNYTLALITYALSSVG-SPKAKEALNMLtWRAEQEGG 880
Cdd:COG2373 1256 YRLAVRAYALYVLARAG----KADLGDLRYLYDRRKDA----LSPLAKAQLAAALALLGdKARAEELLAAA-LARLRETG 1326
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 881 M--QFWVSSESKLSDswqpRSLdievAAYALLSHFLQFQTSEgiPIMRWLSRQRNSlGGFASTQDTTVALKALSEFAAlM 958
Cdd:COG2373 1327 ArdYWYGDYGSPLRD----QAL----ALALLAELGPDAPLAP--KLARWLAKALKS-GRWLSTQETAWALLALAAYAR-A 1394
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|.
gi 2462606136 959 NTERTNIQVTVTGPSSPSPVkfliDTHNRLLLQTAELAVVQPTAVNISANG 1009
Cdd:COG2373 1395 AGASPDFTATLTLDGKTLPL----TGRGPLARVTLPAAELLAGPLTITNTG 1441
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1069-1156 |
3.56e-27 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
:
Pssm-ID: 462226 Cd Length: 92 Bit Score: 106.11 E-value: 3.56e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 1069 GRSGMALMEVNLLSGFMVPSEAISL---SETVKKVE-YDHGKLNLYLDSVNETQFCVNIPAVRNFKVSNTQDASVSIVDY 1144
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKlgvDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 2462606136 1145 YEPRRQAVRSYN 1156
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
667-954 |
7.52e-152 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 456.65 E-value: 7.52e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 667 SINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSGST 746
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 747 WLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLGYRKYQPNI 826
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 827 DVQESIHFLESEFSrGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFWVS---SESKLSDSWQPRSLDIE 903
Cdd:cd02897 161 VVEKALSCLEAALD-SISDPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHWSRpppSEEGPSYYWQAPSAEVE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 2462606136 904 VAAYALLSHFLQ--FQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 954
Cdd:cd02897 240 MTAYALLALLSAggEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
657-954 |
1.66e-109 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 345.44 E-value: 1.66e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 657 ITAIGDVLGPSI----NGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDG 732
Cdd:pfam07678 1 ISVVGDIMGPAIqvvpENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 733 SFSAFGNYDPsgSTWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYI 812
Cdd:pfam07678 81 SYSAFGHSPG--STWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTAYV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 813 VTSLLGYRKYQPNID-----VQESIHFLESEFSRGISDNYTLALITYALSSVGSPK-AKEALNMLTWRAEQEGGMQFW-- 884
Cdd:pfam07678 159 TIALLEALDINGLLQrvhpsIRKALTYLEQAQLAGLTSPYTLAILAYALALAGSPEtREELLKSLDAMAREEGNSRYWer 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462606136 885 ---VSSESKLSDSWQPRSLDIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 954
Cdd:pfam07678 239 dekSDPQGVPEYPPQAPSLEVETTAYALLAYLLLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVALQALAEY 311
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
6-1009 |
2.13e-38 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 157.16 E-value: 2.13e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 6 LNGTITAKYTYGKPVKG---DVTLTFLPLSFwgkkknitkTFKinGSANFSFNDEEMKN---VMDSSNG----------- 68
Cdd:COG2373 489 VTVTVDARYLFGAPAAGlkvEGEVTLRPART---------AFP--GYPGYRFGDPDEEFepeELDLGEGtldadgkasls 557
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 69 --LSEYLDLSSPGPVEILTTVTESvTG--ISRNVSTNVFFKQHdYI-IEFFDYTTVLKPSlNFTATVKVTRADGNQLTle 143
Cdd:COG2373 558 lpLPDAPDAPGPLRATVEASVFES-GGrpVTRSATVPVHPADF-YVgIRLPLFDGDPEGA-PATFEVVAVDPDGKPVA-- 632
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 144 erRNNVVITVTQRNYTEYWSGSNSGNQKMEAVQK------------------INYTVPQSGTFKIEfpiLEDSSELQL-- 203
Cdd:COG2373 633 --GKGLKVELYREEWRYVWYKSDDGGWRYESQEKeepvaegtlttgadgpasLSLTPVEWGRYRLE---VKDPDGGLAts 707
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 204 KAYFLGSKSSmavhslFKSPSKTYIQLKTRDENIKVG--------SPFE----LVVSGNKRLKElsymvvsrgQLVAVGK 271
Cdd:COG2373 708 VRFYAGGNAS------WGAERPDRLELSLDKESYKPGetaklliqSPFAgralVTVERDGVLET---------QWVDVKG 772
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 272 qNSTMFSLTPENSWTPKACVIVYYI--EDDGEIISD-----VLKIPVQLV-FKNKIKLywsKV--KAEPSEKVSLRISVT 341
Cdd:COG2373 773 -GGTTVEIPVTEDWAPNAYVSATLVrpGDSTANDMParaygVAPLPVDPPaRRLKVEL---TApeKLRPGETLTVTVKVK 848
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 342 QPD---SIVGIVAVDKSV-NLMNasnditmenvvhelelYNT----GYYlgmfmnsfavFQECGLWVLTDANLtkDYIDG 413
Cdd:COG2373 849 GAAgkaAEVTLAAVDEGIlNLTG----------------YKTpdplDFF----------YGKRALGVETRDLY--GRLIG 900
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 414 VYDNAEYAERF---MEENEGhivdihdfslGSSPHVRKHFPETWIW---LDTNMGSRIyqEFEVTVPDSITSWVATGFVI 487
Cdd:COG2373 901 AFGGAAGALRSggdGALGRG----------GNPKPPRKRFKPVALFsgpVKTDADGKA--TVSFDLPDFNGTLRVMAVAW 968
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 488 SED-LGLGLTTTPVElqafQPFFIFLNLPYSVIRGEEFALEITIFNYLKDATEVKVIIEKSDKFDILMTSSeinatghqQ 566
Cdd:COG2373 969 SDDrFGSAEATVTVR----KPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEGEAT--------Q 1036
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 567 TLLVPSEDGATVLFPIRPTHLGEIPITVTALSPTASDAITQMILVKAEGIEKSYSQSILLDltdnrlQSTLKTLSFSFPP 646
Cdd:COG2373 1037 TVTLAAGGRATVRFPLKAPDAGDAKVTVTATGGGESDAREVELPVRPANPLVTRATSGVLA------PGESWTLPLDLPG 1110
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 647 NTVTGSERVQI----TAIGDVLGpsinGLASLIRMPYGCGEQNMINFAPNIYILDyLTKKKQLTDNLKEKALSFMRQGYQ 722
Cdd:COG2373 1111 GLRPGTGSLTLslssSPPLDLAG----LLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIA 1185
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 723 RELLYQREDGSFSAFGNYDPSgSTWLSAFVLRCFLEADPY-IDIDQNVLHRTYTWLKGHQKSNGEFwdpgrvihsELQGG 801
Cdd:COG2373 1186 RLLSMQNSDGGFGLWPGGSES-DPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPWEI---------EYDDA 1255
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 802 NKSPVTLTAYIVTSLLGyrkyQPNIDVQESIHFLESEFsrgiSDNYTLALITYALSSVG-SPKAKEALNMLtWRAEQEGG 880
Cdd:COG2373 1256 YRLAVRAYALYVLARAG----KADLGDLRYLYDRRKDA----LSPLAKAQLAAALALLGdKARAEELLAAA-LARLRETG 1326
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 881 M--QFWVSSESKLSDswqpRSLdievAAYALLSHFLQFQTSEgiPIMRWLSRQRNSlGGFASTQDTTVALKALSEFAAlM 958
Cdd:COG2373 1327 ArdYWYGDYGSPLRD----QAL----ALALLAELGPDAPLAP--KLARWLAKALKS-GRWLSTQETAWALLALAAYAR-A 1394
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|.
gi 2462606136 959 NTERTNIQVTVTGPSSPSPVkfliDTHNRLLLQTAELAVVQPTAVNISANG 1009
Cdd:COG2373 1395 AGASPDFTATLTLDGKTLPL----TGRGPLARVTLPAAELLAGPLTITNTG 1441
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
453-544 |
1.36e-35 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 130.01 E-value: 1.36e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 453 TWIWLDTNMGSRIYQEFEVTVPDSITSWVATGFVISEDLGLGLTTtPVELQAFQPFFIFLNLPYSVIRGEEFALEITIFN 532
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAE-PPELVVFKPFFVDLNLPYSVRRGEQFELKATVFN 79
|
90
....*....|..
gi 2462606136 533 YLKDATEVKVII 544
Cdd:pfam00207 80 YLDKCLKVRVRL 91
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1069-1156 |
3.56e-27 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 106.11 E-value: 3.56e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 1069 GRSGMALMEVNLLSGFMVPSEAISL---SETVKKVE-YDHGKLNLYLDSVNETQFCVNIPAVRNFKVSNTQDASVSIVDY 1144
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKlgvDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 2462606136 1145 YEPRRQAVRSYN 1156
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
667-954 |
7.52e-152 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 456.65 E-value: 7.52e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 667 SINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPSGST 746
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 747 WLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLGYRKYQPNI 826
Cdd:cd02897 81 WLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPSERP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 827 DVQESIHFLESEFSrGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFWVS---SESKLSDSWQPRSLDIE 903
Cdd:cd02897 161 VVEKALSCLEAALD-SISDPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHWSRpppSEEGPSYYWQAPSAEVE 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 2462606136 904 VAAYALLSHFLQ--FQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 954
Cdd:cd02897 240 MTAYALLALLSAggEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
667-954 |
3.19e-110 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 346.30 E-value: 3.19e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 667 SINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPsGST 746
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDS-GST 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 747 WLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSLLGYRKYQPNI 826
Cdd:cd02891 80 WLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKACDAS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 827 dVQESIHFLESEFSrGISDNYTLALITYALSSVG-SPKAKEALNMLTWRAEQEGGMQFWVSSesklSDSWQPRSLDIEVA 905
Cdd:cd02891 160 -IEKALAYLETQLD-GLLDPYALAILAYALALAGdSTRADEALKKLLEAAREKGGTAHWSLS----WPGDYGSSLRVEAT 233
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 2462606136 906 AYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 954
Cdd:cd02891 234 AYALLALLKLGDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
657-954 |
1.66e-109 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 345.44 E-value: 1.66e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 657 ITAIGDVLGPSI----NGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDG 732
Cdd:pfam07678 1 ISVVGDIMGPAIqvvpENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 733 SFSAFGNYDPsgSTWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYI 812
Cdd:pfam07678 81 SYSAFGHSPG--STWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTAYV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 813 VTSLLGYRKYQPNID-----VQESIHFLESEFSRGISDNYTLALITYALSSVGSPK-AKEALNMLTWRAEQEGGMQFW-- 884
Cdd:pfam07678 159 TIALLEALDINGLLQrvhpsIRKALTYLEQAQLAGLTSPYTLAILAYALALAGSPEtREELLKSLDAMAREEGNSRYWer 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462606136 885 ---VSSESKLSDSWQPRSLDIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 954
Cdd:pfam07678 239 dekSDPQGVPEYPPQAPSLEVETTAYALLAYLLLGDLTYADPIVKWLTSQRNSHGGFSSTQDTVVALQALAEY 311
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
667-954 |
1.19e-85 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 280.31 E-value: 1.19e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 667 SINGLASLIRMPYGCGEQNMINFAPNIYILDYLTKKKQ---LTDNLKEKALSFMRQGYQRELLYQREDGSFSAFGNYDPS 743
Cdd:cd02896 1 SPEGLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQwekLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNRPSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 744 gsTWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGG---NKSPVTLTAYIVTSLLGYR 820
Cdd:cd02896 81 --TWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGvegSEGDVSLTAFVLIALQEAR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 821 KYQPNI--DVQESIH----FLESEFSrGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGGMQFWVSSESKLSDS 894
Cdd:cd02896 159 SICPPEvqNLDQSIRkaisYLENQLP-NLQRPYALAITAYALALADSPLSHAANRKLLSLAKRDGNGWYWWTIDSPYWPV 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 895 WQPRSLDIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF 954
Cdd:cd02896 238 PGPSAITVETTAYALLALLKLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAEY 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
667-954 |
3.87e-68 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 231.29 E-value: 3.87e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 667 SINGLASLIRMPYG--------CGEQNMINFAPNIYILDYLTkkkqlTDNLKEKALSFMRQGYQRELLYQREDGSFSAFG 738
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLA-----ATGIRDKADENIEKGIQRLLSYQLSDGGFSGWG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 739 NYDpSGSTWLSAFVLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSelQGGNKSPVTLTAYIVTSLLG 818
Cdd:cd00688 76 GND-YPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHR--IGGDESDVRLTAYALIALAL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 819 YRKYQPNIDVQESIHFLESEF-------SRGISDNYTLALITYALSSVGS---PKAKEALNMLTWRAEQEGGMQFWVSSE 888
Cdd:cd00688 153 LGKLDPDPLIEKALDYLLSCQnydggfgPGGESHGYGTACAAAALALLGDldsPDAKKALRWLLSRQRPDGGWGEGRDRT 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2462606136 889 SKLSDswqprSLDIEVAAYALLSHFLQFQTSEGIPIMRWLSRQRNSLGGFAS-------TQDTTVALKALSEF 954
Cdd:cd00688 233 NKLSD-----SCYTEWAAYALLALGKLGDLEDAEKLVKWLLSQQNEDGGFSSkpgksydTQHTVFALLALSLY 300
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
6-1009 |
2.13e-38 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 157.16 E-value: 2.13e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 6 LNGTITAKYTYGKPVKG---DVTLTFLPLSFwgkkknitkTFKinGSANFSFNDEEMKN---VMDSSNG----------- 68
Cdd:COG2373 489 VTVTVDARYLFGAPAAGlkvEGEVTLRPART---------AFP--GYPGYRFGDPDEEFepeELDLGEGtldadgkasls 557
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 69 --LSEYLDLSSPGPVEILTTVTESvTG--ISRNVSTNVFFKQHdYI-IEFFDYTTVLKPSlNFTATVKVTRADGNQLTle 143
Cdd:COG2373 558 lpLPDAPDAPGPLRATVEASVFES-GGrpVTRSATVPVHPADF-YVgIRLPLFDGDPEGA-PATFEVVAVDPDGKPVA-- 632
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 144 erRNNVVITVTQRNYTEYWSGSNSGNQKMEAVQK------------------INYTVPQSGTFKIEfpiLEDSSELQL-- 203
Cdd:COG2373 633 --GKGLKVELYREEWRYVWYKSDDGGWRYESQEKeepvaegtlttgadgpasLSLTPVEWGRYRLE---VKDPDGGLAts 707
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 204 KAYFLGSKSSmavhslFKSPSKTYIQLKTRDENIKVG--------SPFE----LVVSGNKRLKElsymvvsrgQLVAVGK 271
Cdd:COG2373 708 VRFYAGGNAS------WGAERPDRLELSLDKESYKPGetaklliqSPFAgralVTVERDGVLET---------QWVDVKG 772
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 272 qNSTMFSLTPENSWTPKACVIVYYI--EDDGEIISD-----VLKIPVQLV-FKNKIKLywsKV--KAEPSEKVSLRISVT 341
Cdd:COG2373 773 -GGTTVEIPVTEDWAPNAYVSATLVrpGDSTANDMParaygVAPLPVDPPaRRLKVEL---TApeKLRPGETLTVTVKVK 848
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 342 QPD---SIVGIVAVDKSV-NLMNasnditmenvvhelelYNT----GYYlgmfmnsfavFQECGLWVLTDANLtkDYIDG 413
Cdd:COG2373 849 GAAgkaAEVTLAAVDEGIlNLTG----------------YKTpdplDFF----------YGKRALGVETRDLY--GRLIG 900
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 414 VYDNAEYAERF---MEENEGhivdihdfslGSSPHVRKHFPETWIW---LDTNMGSRIyqEFEVTVPDSITSWVATGFVI 487
Cdd:COG2373 901 AFGGAAGALRSggdGALGRG----------GNPKPPRKRFKPVALFsgpVKTDADGKA--TVSFDLPDFNGTLRVMAVAW 968
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 488 SED-LGLGLTTTPVElqafQPFFIFLNLPYSVIRGEEFALEITIFNYLKDATEVKVIIEKSDKFDILMTSSeinatghqQ 566
Cdd:COG2373 969 SDDrFGSAEATVTVR----KPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEGEAT--------Q 1036
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 567 TLLVPSEDGATVLFPIRPTHLGEIPITVTALSPTASDAITQMILVKAEGIEKSYSQSILLDltdnrlQSTLKTLSFSFPP 646
Cdd:COG2373 1037 TVTLAAGGRATVRFPLKAPDAGDAKVTVTATGGGESDAREVELPVRPANPLVTRATSGVLA------PGESWTLPLDLPG 1110
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 647 NTVTGSERVQI----TAIGDVLGpsinGLASLIRMPYGCGEQNMINFAPNIYILDyLTKKKQLTDNLKEKALSFMRQGYQ 722
Cdd:COG2373 1111 GLRPGTGSLTLslssSPPLDLAG----LLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIA 1185
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 723 RELLYQREDGSFSAFGNYDPSgSTWLSAFVLRCFLEADPY-IDIDQNVLHRTYTWLKGHQKSNGEFwdpgrvihsELQGG 801
Cdd:COG2373 1186 RLLSMQNSDGGFGLWPGGSES-DPWLTAYATDFLLEAREAgYAVPDDALDRALDYLRNYLRNPWEI---------EYDDA 1255
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 802 NKSPVTLTAYIVTSLLGyrkyQPNIDVQESIHFLESEFsrgiSDNYTLALITYALSSVG-SPKAKEALNMLtWRAEQEGG 880
Cdd:COG2373 1256 YRLAVRAYALYVLARAG----KADLGDLRYLYDRRKDA----LSPLAKAQLAAALALLGdKARAEELLAAA-LARLRETG 1326
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 881 M--QFWVSSESKLSDswqpRSLdievAAYALLSHFLQFQTSEgiPIMRWLSRQRNSlGGFASTQDTTVALKALSEFAAlM 958
Cdd:COG2373 1327 ArdYWYGDYGSPLRD----QAL----ALALLAELGPDAPLAP--KLARWLAKALKS-GRWLSTQETAWALLALAAYAR-A 1394
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|.
gi 2462606136 959 NTERTNIQVTVTGPSSPSPVkfliDTHNRLLLQTAELAVVQPTAVNISANG 1009
Cdd:COG2373 1395 AGASPDFTATLTLDGKTLPL----TGRGPLARVTLPAAELLAGPLTITNTG 1441
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
453-544 |
1.36e-35 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 130.01 E-value: 1.36e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 453 TWIWLDTNMGSRIYQEFEVTVPDSITSWVATGFVISEDLGLGLTTtPVELQAFQPFFIFLNLPYSVIRGEEFALEITIFN 532
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAE-PPELVVFKPFFVDLNLPYSVRRGEQFELKATVFN 79
|
90
....*....|..
gi 2462606136 533 YLKDATEVKVII 544
Cdd:pfam00207 80 YLDKCLKVRVRL 91
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1069-1156 |
3.56e-27 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 106.11 E-value: 3.56e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 1069 GRSGMALMEVNLLSGFMVPSEAISL---SETVKKVE-YDHGKLNLYLDSVNETQFCVNIPAVRNFKVSNTQDASVSIVDY 1144
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKlgvDPLIKRVEtVDDGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 2462606136 1145 YEPRRQAVRSYN 1156
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
228-359 |
3.43e-24 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 99.35 E-value: 3.43e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 228 IQLKTRDENIKVGSPFELVV----SGNKRLKELSYMVVSRGQLVAVG-KQNSTMFSLTPENSWTPKACVIVYYI---EDD 299
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVkspfDGTVERDGFTYLVLSKGQIVVVGrGGVTTSFSLPVTAEMAPSARVVAYYVrvdLSK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2462606136 300 GEIISDVLKIPVQLVFKNKIKLYWSKVKAEPSEKVSLRISVtQPDSIVGIVAVDKSVNLM 359
Cdd:pfam07703 81 PEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKA-DPGAYVALAAVDKGVLLL 139
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
1-61 |
7.03e-11 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 59.59 E-value: 7.03e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2462606136 1 MNSKHLNGTITAKYTYGKPVKGDVTLTFLPLSFWGKKKN--ITKTFKING--SANFSFNDEEMKN 61
Cdd:pfam17791 19 VKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDDSKRKCFesFSKELDKDGcgSASLSTEEFQLTF 83
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